| a nosocomial outbreak of epidemic keratoconjunctivitis due to adenovirus type 37. | an outbreak of epidemic keratoconjunctivitis occurred at the department of ophthalmology of a hospital in yokohama, involving 14 inpatients, 12 outpatients, and 2 doctors. adenovirus type 37 (ad-37) was isolated from the conjunctival swab in 12 of 18 cases. in neutralization tests, the isolates showed some cross-reaction with adenovirus type 19 (ad-19). the ad-37 isolates were indistinguishable from each other and from the prototype ad-37, but distinct from the prototype ad-19 in the restriction ... | 1990 | 2178212 |
| an epidemic of keratoconjunctivitis due to adenovirus type 37. | an epidemic of keratoconjunctivitis due to adenovirus type 37 in liverpool in 1984 is reported. initially serum neutralisation suggested that isolates were type 10 but further neutralisation studies supported by dna restriction enzyme analysis showed that they were type 37. clinical and epidemiological features of this cause of epidemic keratoconjunctivitis, recently recognised in the united kingdom, are presented and the implications for the laboratory investigation discussed. | 1988 | 2841171 |
| genome type analysis of adenovirus 37 isolates. | seventy-six strains of adenovirus type 37 (av37), isolated during a period of 10 years from 73 patients on three continents, were analysed with eight dna restriction endonucleases. strains identical with the prototype (56 strains) prevailed; four deviating genome types were found, which differed only slightly from the prototype, with one exception. half of the strains were tested in detail by neutralisation and haemagglutination inhibition. minor differences in neutralisation were not reflected ... | 1988 | 2842449 |
| [clinico-epidemiological study of keratoconjunctivitis due to adenovirus type 37 (ad 37) in sapporo, japan]. | | 1985 | 2988316 |
| [acute haemorrhagic conjunctivitis caused by a subtype of adenovirus type 37]. | | 1985 | 2992248 |
| viral conjunctivitis with special reference to adenovirus type 37 and enterovirus 70 infection. | the clinical and etiological findings in 727 patients with viral conjunctivitis treated from january 1982 through december 1984 at aoki eye clinic in sapporo, japan, were presented. the age of the patients ranged from 11 days to 88 years, and the monthly incidences of the disease from 18 to 131 cases, with a clustering in the summer season. the etiological diagnosis was established in 399 (54.9%) of the 727 patients: adenovirus (ad) 3 in 45 cases; ad4 in 98 cases; ad8 in 57 cases; ad19 in 23 cas ... | 1986 | 3020290 |
| keratoconjunctivitis associated with adenovirus type 37: an extended outbreak in an ophthalmologist's office. | an outbreak of epidemic keratoconjunctivitis occurred in three clusters among patients of an ophthalmologist during 1977-1978. cases in the third cluster and possibly one case in the first were caused by infection with adenovirus type 37. among 83 infected patients, the mean interval between a visit to the ophthalmologist's office and the onset of symptoms was 11 days. conjunctival specimens from 64 (77%) of the patients yielded adenovirus type 37, and adenovirus hexon antigen was identified by ... | 1983 | 6298314 |
| epidemic keratoconjunctivitis in a chronic care facility: risk factors and measures for control. | to study patterns of transmission of epidemic keratoconjunctivitis (ekc) in a chronic care facility and to assess control measures and prevent future outbreaks in this setting. | 1993 | 8227890 |
| acute hemorrhagic cystitis by adenovirus type 11 with and without type 37 after kidney transplantation. | we report 2 kidney transplant patients with acute hemorrhagic cystitis. adenovirus type 11 was isolated in the urine of both patients and in 1 patient adenovirus type 37 was also isolated. each developed macrohematuria with urgency, micturition pain, elevated fever and functional deterioration of the transplanted kidney possibly due to acute rejection. these symptoms and laboratory data suggesting renal impairment persisted for approximately 4 weeks after therapy for acute rejection had been sta ... | 1996 | 8659005 |
| [genome types of adenovirus type 37 with different pathogenicity isolated in nagoya city]. | out of 217 strains of viruses isolated from patients with conjunctivitis at one ophthalmology clinic in nagoya city from 1982 to 1995, 37 were adenovirus type 37 (ad37). they were isolated mainly from patients with epidemic keratoconjunctivitis in summer-time. dnas from all ad37 isolates were extracted and analyzed by five restriction endonucleases (bam h i, eco r i, hind iii, sal i and sma i) in comparison with prototype strain. thirty-seven isolates were divided into six genome types (ad37a, a ... | 1997 | 9311188 |
| an outbreak of epidemic keratoconjunctivitis caused by adenovirus type 37. | an outbreak of acute keratoconjunctivitis in an ophthalmology department affected 15 patients and seven members of staff and necessitated temporary closure of the unit. adenovirus (ad) was isolated from eye swabs taken during the outbreak, but typing of the isolates by virus neutralisation assay proved unsatisfactory, wrongly assigning the isolate to serotype 10. a robust and rapid method for preparing microgram amounts of ad dna from infected cells was devised and used as the basis of a non-rad ... | 1998 | 9449955 |
| a single amino acid in the adenovirus type 37 fiber confers binding to human conjunctival cells. | a 46-kda receptor, coxsackievirus-adenovirus (ad) receptor (car), mediates cell attachment of a number of different ad serotypes; however, not all ad serotypes utilize this receptor for infection. moreover, the precise amino acid sequences in the ad fiber protein that mediate cell attachment have yet to be identified. we investigated the interaction of subgroup d ads with human ocular cells. ad serotype 37 (ad37), a virus associated with epidemic keratoconjunctivitis, but not a closely related v ... | 1999 | 10074127 |
| adenovirus type 37 uses sialic acid as a cellular receptor. | two cellular receptors for adenovirus, coxsackievirus-adenovirus receptor (car) and major histocompatibility complex class i (mhc-i) alpha2, have recently been identified. in the absence of car, mhc-i alpha2 has been suggested to serve as a cellular attachment protein for subgenus c adenoviruses, while members from all subgenera except subgenus b have been shown to interact with car. we have found that adenovirus type 37 (ad37) attachment to car-expressing cho cells was no better than that to ch ... | 2000 | 10590089 |
| a 50-kda membrane protein mediates sialic acid-independent binding and infection of conjunctival cells by adenovirus type 37. | the ocular tropism of adenovirus type 37 (ad37) does not correlate with the wide distribution of the 46-kda coxsackievirus and adenovirus receptor (car), the major receptor for most adenovirus serotypes. we previously found that ad37 infects and binds well to conjunctival cells (chang c), but poorly to lung epithelial (a549) cells that express car and hypothesized that this serotype uses a distinct receptor that is selectively expressed on conjunctival cells. to test this, we produced particles ... | 2001 | 11145891 |
| interleukin-1alpha released from epithelial cells after adenovirus type 37 infection activates intercellular adhesion molecule 1 expression on human vascular endothelial cells. | a key event in virus-induced inflammation (leukocyte extravasation through the endothelium) is the local activation of endothelial cells, as indicated by the expression of adhesion molecules such as intercellular adhesion molecule 1 (icam-1), vascular cell adhesion molecule 1 (vcam-1), and e-selectin. in order to identify triggers of inflammation in adenovirus infection, we inoculated respiratory and ocular epithelial cells with adenovirus type 37 (ad37), a human pathogen associated with keratoc ... | 2002 | 11739709 |
| adenovirus type 37 uses sialic acid as a cellular receptor on chang c cells. | epidemic keratoconjunctivitis (ekc) is a severe eye infection caused mainly by adenovirus type 8 (ad8), ad19, and ad37. we have shown that the ekc-causing adenoviruses use sialic acid as a cellular receptor on a549 cells instead of the coxsackie-adenovirus receptor, which is used by most adenoviruses. recently, wu et al. (virology 279:78-89, 2001) proposed that ad37 uses a 50-kda protein as a receptor on chang c conjunctival cells and that this interaction is independent of sialic acid. accordin ... | 2002 | 12163603 |
| adenovirus type 37 binds to cell surface sialic acid through a charge-dependent interaction. | most adenoviruses use the coxsackie-adenovirus receptor (car) as a major cellular receptor. we have shown recently that adenovirus types 8, 19a, and 37, which are the major causes of epidemic keratoconjunctivitis, use sialic acid rather than car as a major cellular receptor. the predicted isoelectric point of the receptor-interacting knob domain in the adenovirus fiber protein is unusually high (9.0-9.1) in type 8, 19a, and 37. the pka of sialic acid is low, 2.6, implying a possible involvement ... | 2002 | 12429514 |
| adenovirus type 5 pseudotyped with adenovirus type 37 fiber uses sialic acid as a cellular receptor. | for purposes of gene therapy, the tropism of adenovirus (ad) serotype 5 vectors can be altered with fibers derived from alternative serotypes. however, there is currently limited information available on the cellular receptors used by the approximately 51 known ad serotypes. recently, alpha(2-->3)-linked sialic acid (2,3-sa) has been implicated as the cellular receptor for wild-type ad37. however, some studies have demonstrated that wild-type ad37 uses a 50-kda protein and not sialic acid as its ... | 2004 | 15183060 |
| multivalent hsa conjugates of 3'-sialyllactose are potent inhibitors of adenoviral cell attachment and infection. | adenoviruses of serotypes 8, 19 and 37 are the major cause of the severe eye infection ekc (epidemic keratoconjunctivitis). in general, all adenoviruses interact with their cellular receptors through the fibre proteins, which extend from the virus particle. recently, adenovirus type 37 (ad37) was found to bind and infect human corneal cells through attachment to carbohydrate structures that carry terminal alpha-(2-3)-linked sialic acids. herein we present a synthetic route to a 3'-sialyllactose ... | 2005 | 15678425 |
| five new genome types of adenovirus type 37 caused epidemic keratoconjunctivitis in sapporo, japan, for more than 10 years. | human adenovirus type 37 (hadv-37) is a major cause of epidemic keratoconjunctivitis and has recently been the largest causative agent of keratoconjunctivitis in japan. to investigate the genetic characteristics of hadv-37 strains isolated in sapporo, we analyzed the genome types and genetic relationships of 51 strains isolated there from 1990 through 2001. by using dna restriction analysis, eight genome types (hadv-37/d1, hadv-37/d3, and hadv-37/d6 to hadv-37/d11) were identified, including fiv ... | 2005 | 15695671 |
| cd46-utilizing adenoviruses inhibit c/ebpbeta-dependent expression of proinflammatory cytokines. | the majority of adenovirus serotypes utilize the coxsackievirus-adenovirus receptor (car) for virus-host cell attachment, but subgroup b and subgroup d (adenovirus type 37 [ad37]) viruses recognize cd46. cd46 is a ubiquitously expressed receptor that serves as a cofactor for the inactivation of the complement components c3b and c4b, and it also serves as a receptor for diverse microbial pathogens. a reported consequence of cd46 engagement is a reduced capability of human immune cells to express ... | 2005 | 16103178 |
| [clinical and virological studies of nosocomial conjunctivitis infection caused by adenovirus type 37 variant]. | to study the clinical features and virological analysis of the nosocomial adenoviral conjunctivitis cases occurring in the ophthalmology ward of fukushima medical university hospital. | 2005 | 16164232 |
| multivalent sialic acid conjugates inhibit adenovirus type 37 from binding to and infecting human corneal epithelial cells. | adenovirus type 37 is one of the main causative agents of epidemic keratoconjunctivitis. in a series of publications, we have reported that this virus uses sialic acid as a cellular receptor. here we demonstrate in vitro that on a molar basis, multivalent sialic acid conjugated to human serum albumin prevents adenovirus type 37 from binding to and infecting human corneal epithelial cells 1000-fold more efficiently than monosaccharidic sialic acid. we also demonstrate that the extraordinary inhib ... | 2007 | 17014916 |
| adenovirus type 37 keratitis in the c57bl/6j mouse. | to develop a mouse model of adenoviral keratitis that will allow further study of viral and host pathogenic mechanisms. | 2007 | 17251478 |
| human adenovirus type 37 and the balb/c mouse: progress toward a restricted adenovirus keratitis model (an american ophthalmological society thesis). | to establish a mouse model of adenovirus keratitis in order to study innate immune mechanisms in the adenovirus-infected cornea. | 2006 | 17471351 |
| genomic and bioinformatics analysis of human adenovirus type 37: new insights into corneal tropism. | human adenovirus type 37 (hadv-37) is a major etiologic agent of epidemic keratoconjunctivitis, a common and severe eye infection associated with long-term visual morbidity due to persistent corneal inflammation. while hadv-37 has been known for over 20 years as an important cause, the complete genome sequence of this serotype has yet to be reported. a detailed bioinformatics analysis of the genome sequence of hadv-37 is extremely important to understanding its unique pathogenicity in the eye. | 2008 | 18471294 |
| insufficient accumulation of viral late mrnas restricts the replicative cycle of human adenovirus type 37 in a549 cells. | most serotypes of human adenoviruses, except subgroup c viruses such as serotype 2 (ad2) and ad5, can grow only to low titers in vitro in human cell lines. to analyze the properties of the replicative cycles of poorly growing ad serotypes, we compared ad37 and ad5 in human a549 cells. in comparison with ad5, ad37 showed a slower development of viral-induced cytopathic effects and prolonged cell viability. furthermore, the maximum yields of progeny viruses were reduced by almost 100-fold. althoug ... | 2009 | 19609636 |
| [three cases of acute conjunctivitis caused by human adenovirus in medical workers]. | we report three cases of acute conjunctivitis due to different types of human adenovirus (hadv) in medical workers. case 1: a 37-year-old man had epidemic keratoconjunctivitis and urethritis caused by human adenovirus type 37 (hadv-37). case 2: a 27-year-old woman had acute conjunctivitis due to human adenovirus type 15 (hadv-15), case 3:a 32-year-old woman had acute follicular conjunctivitis leading to a serotype of human adenovirus-53 serotype (hadv-53). note that hadv-37 infection may cause k ... | 2010 | 20715560 |
| molecular epidemiology of adenoviral keratoconjunctivitis in saudi arabia. | adenoviral keratoconjunctivitis is a major cause of ocular morbidity and may lead to visual loss. adenovirus types 8, 19, and 37 may cause epidemic keratoconjunctivitis. the main objective of this study was to determine the types of adenoviruses causing keratoconjunctivitis in saudi arabia. | 2010 | 21139691 |
| the gd1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis. | adenovirus type 37 (ad37) is a leading cause of epidemic keratoconjunctivitis (ekc), a severe and highly contagious ocular disease. whereas most other adenoviruses infect cells by engaging cd46 or the coxsackie and adenovirus receptor (car), ad37 binds previously unknown sialic acid-containing cell surface molecules. by glycan array screening, we show here that the receptor-recognizing knob domain of the ad37 fiber protein specifically binds a branched hexasaccharide that is present in the gd1a ... | 2010 | 21151139 |
| a potent trivalent sialic acid inhibitor of adenovirus type 37 infection of human corneal cells. | | 2011 | 21648036 |