| effect of ayurvedic medicines on beta-glucuronidase activity of brunner's glands during recovery from cysteamine induced duodenal ulcers in rats. | biochemical and histochemical studies revealed decreased beta-glucuronidase activity in the brunner's glands of duodenal ulcerated rats. the enzyme activity showed gradual increase during recovery. rats treated with a mixture of ayurvedic medicines (glycyrrhiza glabra, terminalia chebula, piper longum and shanka bhasma) recovered faster with concomitant increase in beta-glucuronidase activity in the brunner's glands. it can be concluded that ayurvedic medicines used do not act as antacid but imp ... | 1989 | 2620935 |
| antifertility effects of the fruits of piper longum in female rats. | | 1979 | 468331 |
| alkaloids of piper longum linn. i. structure and synthesis of piperlongumine and piperlonguminine. | | 1967 | 6047519 |
| dehydropipernonaline, an amide possessing coronary vasodilating activity, isolated from piper longum l. | an amide (dehydropipernonaline) that has coronary vasorelaxant activity was isolated from the fruit of piper longum l. this substance was characterized on the basis of spectroscopic data. | 1986 | 3559927 |
| antifertility activity of three indigenous plant preparations. | the antifertility effects of preparations of lajjal (a blend of piper longum, arsenii trisulphidium, jawari mastaki, and borax), avrodhak (lawsonia inermis), and kalyani (abrus precatorius) were studied in pregnant rate. avrodhak, in a daily dose of either 3, 30, or 300 mg, showed a 40-60% inhibition of pregnancy. the other preparations were without effect. the infertility produced by the powdered leaves of lawsonia inermis appeared to be permanent. | 1977 | 840932 |
| management of giardiasis by an immuno-modulatory herbal drug pippali rasayana. | pippali rasayana (pr), an ayurvedic herbal medicine, prepared from piper longum (pippali) and butea monosperma (palash), and prescribed for the treatment of chronic dysentery and worm infestations was tested for anti-giardial and immuno-stimulatory activity in mice, infected with giardia lamblia trophozoites. it produced up to 98% recovery from the infection. the rasayana had no killing effect on the parasite in vitro. it induced significant activation of macrophages as evidenced by increased ma ... | 1994 | 7898121 |
| scientific evidence on the role of ayurvedic herbals on bioavailability of drugs. | experiments were conducted to evaluate the scientific basis of the use of the trikatu group of acrids (long pepper, black pepper and ginger) in the large number of prescriptions in ayurveda. [3h] vasicine and [3h] sparteine were taken as test drugs. piper longum (long pepper) increased the blood levels of vasicine by nearly 233%. under the influence of piperine, the active principle of piper species, sparteine blood levels increased more than 100%. the results suggest that these acrids have the ... | 1981 | 7311598 |
| management of giardiasis by a herbal drug 'pippali rasayana': a clinical study. | pippali rasayana (pr), an indian ayurvedic drug prepared from palash (butea monosperma (lamk) kuntze; leguminaceae) and pippali (piper longum l.; piperaceae), was administered at a dose of 1 g p.o. three times daily for a period of 15 days to patients (25 treated, 25 placebo controls) suffering from giardiasis with clinical signs and symptoms, and stools positive for trophozoites/cysts of giardia lamblia. after 15 days of drug treatment there was a complete disappearance of g. lamblia (trophozoi ... | 1997 | 9201614 |
| adaptogenic properties of six rasayana herbs used in ayurvedic medicine. | plants from all over the world such as eleutherococcus senticosus, panax ginseng, raponticum carthamoides, rhodiola rosea, withania somnifera and ocimum sanctum have been extensively evaluated for their adaptogenic potential. however, none of them has been successfully introduced as an adaptogen in the clinic. this paper discusses some of the problems in evaluation of adaptogens which have precluded their inclusion as clinically useful drugs. we further discuss our results with six rasayana plan ... | 1999 | 10404532 |
| evaluation of the liver protective potential of piperine, an active principle of black and long peppers. | piperine, an active alkaloidal constituent of the extract obtained from piper longum and piper nigrum, was evaluated for its antihepatotoxic potential in order to validate its use in traditional therapeutic formulations. this plant principle exerted a significant protection against tert-butyl hydroperoxide and carbon tetrachloride hepatotoxicity by reducing both in vitro and in vivo lipid peroxidation, enzymatic leakage of gpt and ap, and by preventing the depletion of gsh and total thiols in th ... | 1993 | 8255933 |
| antiamoebic activity of piper longum fruits against entamoeba histolytica in vitro and in vivo. | the fruits of piper longum used in traditional remedies against intestinal distress have been tested for their efficacy against experimental caecal amoebiasis of rats. the ethanolic extract, hexane fraction, n-butanol soluble fraction exerted in vitro amoebicidal action at 1000 micrograms/ml and the chloroform fraction at 500 micrograms/ml. the ethanolic extract and piperine, a pure compound, from this plant material cured 90% and 40% of rats with caecal amoebiasis, respectively. | 1996 | 8691851 |
| embryotoxicity and teratogenicity studies of an ayurvedic contraceptive--pippaliyadi vati. | an ayurvedic contraceptive--pippaliyadi vati, containing equal parts of powdered seeds or fruit berries of embelia ribes, fruit of piper longum and borax powder was fed orally to two groups of pregnant rats: 2.5 times to one and five times to the other; the recommended dose for humans. the foetuses of mothers fed with pippaliyadi had low birth weights and were smaller in length. the mothers gained less weight during gestation. developmental defects of soft tissues and skeletons were analyzed. th ... | 2001 | 11167037 |
| toxicity studies in mice of common spices, cinnamomum zeylanicum bark and piper longum fruits. | acute (24 hours) and chronic (90 days) oral toxicity studies on the ethanolic extracts of common spices cinnamomum zeylanicum nees bark and piper longum l. fruits were carried out in mice. acute dosages were 0.5, 1.0 and 3 g/kg while the chronic dosage was 100 mg/kg/day. all external morphological, hematological and spermatogenic changes, in addition to body weight and vital organ weights, were recorded. the extracts of both the plants caused no significant acute or chronic mortality compared to ... | 1998 | 9950084 |
| antigiardial and immunostimulatory effect of piper longum on giardiasis due to giardia lamblia. | piper longum fruit, used in traditional remedies as well as in the ayurvedic system of medicine against intestinal disorders, was tested for its efficacy against experimental infection of giardia lamblia in mice. on in vitro test, an aqueous extract of p. longum fruit powder (pf) at 250 microg/ml and its ethanol extract at 125 microg/ml showed 100% giardicidal activity. a low order activity was found in the n-butanol extract. further fractionation in hexane and chloroform resulted in a total los ... | 1999 | 10548746 |
| mosquito larvicidal activity of pipernonaline, a piperidine alkaloid derived from long pepper, piper longum. | a methanol extract of piper longum fruit was found to be active against mosquito larvae of culex pipiens pallens at 10 microg/ml after 24 h. a piperidine alkaloid, pipernonaline, was found to be responsible for this activity, with the 24-h median lethal dose (ld50) value for this compound being 0.21 mg/liter. the ld50 value of pipernonaline was not much higher than those for the 3 organophosphorous insecticides malathion, chlorpyrifos-methyl, and pirimiphos-methyl, used for comparative purpose i ... | 2000 | 11081654 |
| effect of piper longum linn, zingiber officianalis linn and ferula species on gastric ulceration and secretion in rats. | use of dipaniya mahakasaya, a group consisting of 10 herbal drugs, has been suggested in charaka samhita to improve digestion. out of these 10 plants, three, viz. p. longum (water decoction), z. officianalis (water decoction) and ferula species (colloidal solution) were studied for their antiulcer and mechanism of antiulcer effects in rats. all the drugs in the dose of 50 mg/kg, p.o., 60 min prior to experiment, showed significant protection against gastric ulcers induced by 2 hr cold restraint ... | 2000 | 11324171 |
| current status of fertility control methods in india. | approximately 48.2% of couples of 15 to 49 years of age practice family planning methods in india. female sterilization accounts for 34.2%, with male sterilization declining from 3.4% in 1992-93 to 1.9% in 1998-99. use of the condom increased to 3.1% from 2.4%. there is an urgent need for research to develop new contraceptive modalities especially for men and also for women and to make existing methods more safe, affordable and acceptable. current efforts in india to develop a male contraceptive ... | 2001 | 11779954 |
| piperine modulates permeability characteristics of intestine by inducing alterations in membrane dynamics: influence on brush border membrane fluidity, ultrastructure and enzyme kinetics. | piperine (1-piperoyl piperidine) is a major alkaloid of piper nigrum linn. and piper longum linn. it is shown to possess bioavailability-enhancing activity with various structurally and therapeutically diverse drugs. the mechanism of enhancing the bioavailability, is, however, not understood. we hypothesize that piperine's bioavailability-enhancing property may be attributed to increased absorption, which may be due to alteration in membrane lipid dynamics and change in the conformation of enzym ... | 2002 | 12046863 |
| liquid chromatographic method for determination of piperine in rat plasma: application to pharmacokinetics. | piperine, a major alkaloid of piper longum and piper nigrum has been reported to have several pharmacological/toxicological effects. though a number of methods for analysis of this omnipresent food component in pepper fruits are available, its analysis in body fluids has been largely neglected. a high-performance liquid chromatography method for the analysis of piperine in rat plasma is presented in this communication. analysis was performed using a symmetry c(18) column (250x4.6 mm) by isocrati ... | 2002 | 12138007 |
| immunomodulatory and antitumor activity of piper longum linn. and piperine. | alcoholic extract of the fruits of the plant piper longum and its component piperine was studied for their immunomodulatory and antitumor activity. alcoholic extract of the fruits was 100% toxic at a concentration of 500 microg/ml to dalton's lymphoma ascites (dla) cells and 250 microg/ml to ehrlich ascites carcinoma (eac) cells. piperine was found to be cytotoxic towards dla and eac cells at a concentration of 250 microg/ml. alcoholic extract and piperine was also found to produce cytotoxicity ... | 2004 | 15013199 |
| brine shrimp lethality bioassay of selected indian medicinal plants. | ethanolic extracts of six indian medicinal plants, piperine, guggulsterone e and guggulsterone z were tested for cytotoxicity using brine shrimp lethality test. piper longum showed most potent cytotoxic activity. piperine, guggulsterone e and guggulsterone z showed potent activity with lc(50) 2.4, 8.9 and 4.9, respectively. | 2002 | 12385875 |
| potential antiamoebic property of the roots of piper longum linn. | in an earlier study we reported the effect of ethanol extracts of piper longum fruit against caecal amoebiasis in rats. a follow-up study to determine whether the roots possess similar antiamoebic activity was carried out. the ethanolic extract of roots was amoebicidal at 1,000 microg/ml in vitro and cured 88% of caecal amoebiasis cases, suggesting that both the root and fruit of p. longum possess antiamoebic activity to approximately the same extent. | 2002 | 12410557 |
| effect of piperine on the inhibition of lung metastasis induced b16f-10 melanoma cells in mice. | the effect of piperine on the inhibition of lung metastasis induced by b16f-10 melanoma cells was studied in c57bl/6 mice. simultaneous administration of the compound with tumor induction produced a significant reduction (95.2%) in tumor nodule formation. increased lung collagen hydroxyproline (22.37 microg/mg protein) in the metastasized lungs of the control animals compared to normal animals (0.95 microg/mg protein) was significantly reduced (2.59 microg/mg protein) in the piperine-treated ani ... | 2002 | 12553376 |
| enzymatic and non-enzymatic antioxidants in selected piper species. | piper species, commonly used in diet and traditional medicine were assessed for their antioxidant potential. catalase activity was predominated in piper longum, followed by piper cubeba, green pepper, piper brachystachyum and piper nigrum. p. nigrum was richest in glutathione peroxidase and glucose-6-phosphate dehydrogenase, green pepper was richest in peroxidase and vitamin c while vitamin e was more in p. longum and p. nigrum. p. brachystachyum and p. longum were rich sources of vitamin a. all ... | 2003 | 15255605 |
| pharmacokinetic and pharmacodynamic studies on interaction of "trikatu" with diclofenac sodium. | "trikatu"-an ayurvedic formulation comprising of a 1:1:1 ratio of dried fruits of piper nigrum, piper longum and dried rhizomes of zingiber officinale is widely used to enhance the bioavailability of drugs, like vasicine, indomethacin, etc. the enhanced biological response might lead to alteration of therapeutic regimens of commonly prescribed drugs. the present work was aimed to study the effect of concomitant administration of trikatu on the pharmacokinetics and pharmacodynamics of diclofenac ... | 2004 | 15120451 |
| effects of piper longum fruit, piper sarmentosum root and quercus infectoria nut gall on caecal amoebiasis in mice. | the anti-amoebic effects of crude methanol extracts of piper longum fruit, piper sarmentosum root and quercus infectoria nut gall against entamoeba histolytica infecting the caecum of mice were studied. caecal amoebiasis in mice was induced by injection of entamoeba histolytica trophozoites directly into the caecum. the mice were then treated orally with the extract, a standard drug (metronidazole), or vehicle p.o. for five consecutive days, beginning 24 h after the infection and were examined o ... | 2004 | 15120461 |
| guineensine, an acyl-coa: cholesterol acyltransferase inhibitor, from the fruits of piper longum. | bioactivity-guided fractionations for acat inhibitor led to the isolation of guineensine from the chcl (3) extract of piper longum. its structure was identified by spectroscopic means (ir, uv, ms and nmr). guineensine inhibited acat activity in a dose-dependent manner with an ic (50) value of 3.12 micro m. | 2004 | 15254860 |
| analgesic activity of piper longum linn. root. | piper longum root, commonly called kandantippili, is traditionally used to treat rheumatism, insomnia, palsy and epilepsy. but a scientific study on its central actions is not available. this study screens p. longum root for opioid type analgesia using rat tail-flick method and for nsaid type analgesia using acetic-acid writhing method. pentazocine (ip) and ibuprofen (oral) are used as respective drug controls. an aqueous suspension of p. longum root powder is given orally to mice and rat in dos ... | 2003 | 15266916 |
| antioxidant properties of aller-7, a novel polyherbal formulation for allergic rhinitis. | allergic rhinitis, a frequently occurring immunological disorder affecting men, women and children worldwide, is a state of hypersensitivity that occurs when the body overreacts to a substance such as pollen, mold, mites or dust. allergic rhinitis exerts inflammatory response and irritation of the nasal mucosal membranes leading to sneezing; stuffy/runny nose; nasal congestion; and itchy, watery and swollen eyes. a novel, safe polyherbal formulation (aller-7/nr-a2) has been developed for the tre ... | 2004 | 15366786 |
| anti-inflammatory activities of aller-7, a novel polyherbal formulation for allergic rhinitis. | allergic rhinitis is an immunological disorder and an inflammatory response of nasal mucosal membranes. allergic rhinitis, a state of hypersensitivity, occurs when the body overreacts to a substance such as pollens or dust. a novel, safe polyherbal formulation (aller-7/nr-a2) has been developed for the treatment of allergic rhinitis using a unique combination of extracts from seven medicinal plants including phyllanthus emblica, terminalia chebula, terminalia bellerica, albizia lebbeck, piper ni ... | 2004 | 15573692 |
| oral supplementation of piperine leads to altered phase ii enzymes and reduced dna damage and dna-protein cross links in benzo(a)pyrene induced experimental lung carcinogenesis. | in recent years, considerable emphasis has been focused on identifying new chemopreventive agents, which could be useful for the human population. piperine is a pure, pungent alkaloid constituent of black and long peppers (piper nigrum and piper longum), which is a most common spice used throughout the world. in the present study, we examined the protective role of piperine during experimental lung carcinogenesis with reference to its effect on dna damage and detoxification enzyme system. the ac ... | 2005 | 15724447 |
| effect of an indigenous herbal compound preparation 'trikatu' on the lipid profiles of atherogenic diet and standard diet fed rattus norvegicus. | combating heart disease is one of the challenging problems of biomedical science today. towards this goal an indigenous preparation 'trikatu' (a herbal combination containing piper longum (fruit), piper nigrum (fruit) and zingiber officinale (rhizome) dry powder) was fed to normal and cholesterol fed male rattus norvegicus to ascertain its efficacy as a hypolipidaemic agent. its effects on body weight, blood and tissue (aortic, cardiac and hepatic) lipids--total, free and esterified cholesterol, ... | 2004 | 15742354 |
| alteration of pharmacokinetics of oxytetracycline following oral administration of piper longum in hens. | the pharmacokinetic profile of orally administered oxytetracycline (10 mg/kg body weight) was studied 7 days post oral treatment of piper longum (15 mg equivalent/kg) in white leghorn hens (2-2.8 kg). on the day 8, oxytetracycline (otc) was administered orally and blood samples were collected from the wing vein in heparinised vials for plasma separation at 0 (pre-treatment), 15, 30, 60, 120, 240, 360, 480 and 600 minutes post otc administration. plasma otc concentrations were determined by micro ... | 2005 | 16131821 |
| protective effect of piper longum fruit ethanolic extract on radiation induced damages in mice: a preliminary study. | the radioprotective property of an ethanolic extract of piper longum fruits (eeplf) was investigated in swiss mice. the white blood cell (wbc) count in irradiated control mice was drastically reduced to 1900 cells/mm3 on third day but in treated animals the count was 2783.3 cells/mm3. the number of bone marrow cells and alpha-esterase positive cells was also enhanced by the eeplf administration (16.7 x 10(6) cells/femur and 946.5/4000 cells, respectively) when compared to the radiation exposed c ... | 2005 | 16243448 |
| chemopreventive effect of piperine on mitochondrial tca cycle and phase-i and glutathione-metabolizing enzymes in benzo(a)pyrene induced lung carcinogenesis in swiss albino mice. | piperine is a major component of black (piper nigrum linn) and long pepper (piper longum linn) used widely in various systems of traditional medicine. we have evaluated the effect of piperine on mitochondrial tricarboxylic acid cycle and phase i and glutathione-metabolizing enzymes in benzo(a)pyrene induced experimental lung carcinogenesis in swiss albino mice. lung cancer bearing mice showed a significant decrease in the activities of mitochondrial enzymes-isocitrate dehydrogenase (icdh), -keto ... | 2005 | 15881660 |
| in vivo effect of piperine on serum and tissue glycoprotein levels in benzo(a)pyrene induced lung carcinogenesis in swiss albino mice. | in recent years, considerable emphasis has been focused on identifying new cancer chemopreventive agents, which could be useful for the human population. piperine is a pure, pungent alkaloid constituent of black and long peppers (piper nigrum and piper longum), that acts as an antioxidant and anticancer agent by its numerous macromolecules associated with them. in the present study, piperine was found to suppress benzo(a)pyrene (b(a)p) induced lung cancer in swiss albino mice. in lung cancer bea ... | 2006 | 15975841 |
| antioxidant activity of a salt-spice-herbal mixture against free radical induction. | a combination of spices (piper nigrum, piper longum and zingiber officinale), herbs (cyperus rotundus and plumbago zeylanica) and salts make up amrita bindu. the study was focused to evaluate the antioxidant property of individual ingredients in amrita bindu against the free radical 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulphonic acid) (abts). the analysis revealed the antioxidant potential of the ingredients in the following order: piper nigrum>piper longum>cyperus rotundus>plumbago zeylanca> ... | 2006 | 16337350 |
| [study on proliferation effect of extracts of piper longum on mesenchymal stem cells of rat bone marrow and the relationship to chemical functional groups]. | to observe the effect of volatile oil and aqueous soluable part of piper longum on proliferation of rat mesenchymal stem cell (msc) and the chemical functional groups. | 2005 | 16252724 |
| the effects of extracts from anti-diarrheic thai medicinal plants on the in vitro growth of the intestinal protozoa parasite: blastocystis hominis. | the activities of n-hexane, dichloromethane and methanol extracts from five anti-diarrheic thai medicinal plants, acacia catechu (fabaceae) resin, amaranthus spinosus (amaranthaceae) whole plant, brucea javanica (simaroubaceae) seed, piper longum (piperaceae) fruit and quercus infectoria (fagaceae) nut gall were tested against the in vitro growth of fresh isolates of the intestinal protozoan parasite, blastocystis hominis. the extracts at concentrations that ranged from 62.5 to 2000 microg/ml, w ... | 2005 | 15763365 |
| novel aromatic ester from piper longum and its analogues inhibit expression of cell adhesion molecules on endothelial cells. | we report here the isolation and characterization of two active principles, ethyl 3',4',5'-trimethoxycinnamate (1) and piperine (2), from the combined hexane and chloroform extracts of piper longum. using primary human umbilical vein endothelial cells, we evaluated the activities of compound 1 on tnf-alpha-induced expression of cell adhesion molecules, viz., icam-1, vcam-1, and e-selectin, which play key roles in controlling various inflammatory diseases. both compounds 1 and 2 inhibited the tnf ... | 2005 | 16313198 |
| antifertility activity of piper longum linn. in female rats. | the crude extract, its different fractions and the major pure compound from the active fraction of the powdered fruits of piper longum were studied for the antifertility effect in female rats. the crude extract and its hexane fraction exhibited 100 and 86% efficacy respectively (days 1-7 post-coitum (p.c.) schedule). on the other hand, 1-butanol soluble, 1-butanol insoluble and chloroform fractions were inactive. | 2006 | 16401553 |
| inhibition of ccl4-induced liver fibrosis by piper longum linn.? | this study was carried out to evaluate the antifibrotic effect of ethanol extract of the fruits of indian herb piper longum linn. liver fibrosis was induced in rats by ccl(4) administration. the extent of liver fibrosis was assessed by measuring the level of liver hydroxy proline (hp) and serum enzyme levels. following ccl(4) administration hp was significantly increased and serum enzyme levels were elevated. treatment with the ethanol extract of piper longum linn. reduced the hp and also the se ... | 2006 | 16428029 |
| piper longum inhibits vegf and proinflammatory cytokines and tumor-induced angiogenesis in c57bl/6 mice. | the antiangiogenic activity of piper longum was studied using in vivo as well as in vitro models. in vivo, antiangiogenic activity was studied using b16f-10 melanoma cell-induced capillary formation in c57bl/6 mice. intraperitoneal administration of the extract (10 mg/dose/animal) significantly inhibited (50.6%) the number of tumor-directed capillaries induced by injecting b16f-10 melanoma cells on the ventral side of c57bl/6 mice. the cytokine profile in the serum of these animals showed a dras ... | 2006 | 16546703 |
| essential oils as potential adulticides against two populations of aedes aegypti, the laboratory and natural field strains, in chiang mai province, northern thailand. | essential oils derived from five plant species, celery (apium graveolens), caraway (carum carvi), zedoary (curcuma zedoaria), long pepper (piper longum), and chinese star anise (illicium verum), were subjected to investigation of adulticidal activity against mosquito vectors. two populations of aedes aegypti, the laboratory and natural field strains, collected in chiang mai province, northern thailand were tested in pyrethroid-susceptibility bioassays. the results revealed that the natural field ... | 2006 | 16738885 |
| effect of piperine on the steady-state pharmacokinetics of phenytoin in patients with epilepsy. | piperine, the active principle of piper longum, piper nigrum and zingiber officinalis, has been reported to enhance the oral bioavailability of phenytoin in human volunteers. the objective of this study was to explore the effect of a single dose of piperine in patients with uncontrolled epilepsy on the steady-state pharmacokinetics of phenytoin. two groups of 10 patients each receiving either a 150 mg or 200 mg twice daily dose of phenytoin were selected. twelve hours after the night dose, venou ... | 2006 | 16767797 |
| modulation of cadmium induced alterations in murine thymocytes by piperine: oxidative stress, apoptosis, phenotyping and blastogenesis. | piperine, a main component of piper longum linn. and piper nigrum linn., is a plant alkaloid with a long history of medicinal use in indian medicine. it is known to exhibit a variety of biological activities which include anti-pyretic, anti-inflammatory, anti-depressant, hepatoprotective and antitumor. its immunomodulatory role has so far been limited to humoral response. the influence of piperine on murine thymocytes, immunocompromised by cadmium has been reported by us in this investigation. t ... | 2006 | 16780805 |
| hplc assisted chemobiological standardization of alpha-glucosidase-i enzyme inhibitory constituents from piper longum linn-an indian medicinal plant. | formulations of traditional medicines are usually made up of complex mixture of herbs. however, effective quality control methods in order to select right quality materials are lacking. though piper longum is a widely used herb in several ayurvedic formulations prescribed for various diseases, there is no analytical method in the literature so far which can help in selecting the right quality material with proper proportions of the active ingredients (alpha-glucosidase-i enzyme inhibitory princi ... | 2006 | 16872768 |
| postnatal development and reproductive performance of f1 progeny exposed in utero to an ayurvedic contraceptive: pippaliyadi yoga. | pippaliyadi yoga or pippaliyadi vati is an ayurvedic contraceptive used in india since ancient times. it is a combination of powdered fruit berries of embelia ribes burm.f. (myrsinaceae), piper longum l. (piperaceae) and borax in equal proportion. though the contraceptive potential is known since ancient times, no systematic developmental toxicity studies have been carried out. the present study was carried out to evaluate the postnatal developmental toxicity and the reproductive performance of ... | 2007 | 17088035 |
| sodium sulphite enhances rna isolation and sensitivity of cucumber mosaic virus detection by rt-pcr in black pepper. | isolation of intact high quality rna suitable for rt-pcr from black pepper is greatly hindered by the presence of polyphenols and polysaccharides. these compounds adversely affect the sensitivity of virus detection by rt-pcr. the present study evaluated the effect of sodium sulphite in enhancing rna yield and quality in a modified acid guanidium thiocyanate-phenol-chloroform (agpc) protocol. the results were compared with the standard agpc method and rneasy plant mini kit (qiagen) for detection ... | 2007 | 17275931 |
| inhibitory effect of ethanol extract of piper longum l. on rabbit platelet aggregation through antagonizing thromboxane a2 receptor. | piper longum l. has been used as a crude drug for the treatment of disorders of poor peripheral blood circulation in asia. however, the detailed mechanism of its action has not been clarified as yet. in the present study, we examined the effects of several extracts of piper longum l. on rabbit platelet function. thromboxane a(2) receptor agonist u46619 caused rabbit platelet aggregation, which was potently inhibited by the ethanol or butanol extract of piper longum l. the ethanol extract inhibit ... | 2007 | 17603157 |
| inhibition of diacylglycerol acyltransferase by alkamides isolated from the fruits of piper longum and piper nigrum. | pharmacological inhibition of acyl coa:diacylglycerol acyltransferase (dgat, ec 2.3.1.20) has emerged as a potential therapy for the treatment of obesity and type 2 diabetes. bioassay-guided isolation of chcl3 extracts of the fruits of piper longum and piper nigum (piperaceae), using an in vitro dgat inhibitory assay, lead to isolation of a new alkamide named (2e,4z,8e)-n-[9-(3,4-methylenedioxyphenyl)-2,4,8-nonatrienoyl]piperidine (2), together with four known alkamides: retrofractamide c (1), p ... | 2006 | 17177498 |
| suppression of ochratoxin biosynthesis by naturally occurring alkaloids. | the effects of four alkaloids on the biosynthesis of ochratoxin a (ota), ochratoxin b (otb) and citrinin were examined on four ota-producing aspergilli: aspergillus auricomus, a. sclerotiorum and two isolates of a. alliaceus. piperine and piperlongumine, natural alkaloids of piper longum, significantly inhibited ota production at 0.001% (w/v) for all aspergilli examined. piperine and piperlongumine affected the polyketide synthesis step of ota production and inhibited production of citrinin. cur ... | 2007 | 17454112 |
| immunomodulation exhibited by piperinic acid through suppression of proinflammatory cytokines. | piper longum (pl) has been reported for its varied pharmacological activities including bio-enhancer and anti-inflammatory activities in traditional medicine. here the premise of the study was to investigate the immunoregulatory potential of pl and piperinic acid, one of its active constituent, in balb/c mice (in vivo) and human pbmcs (in vitro) models. piperinic acid moderated the proinflammatory mediators and cytokines in our experiments. at doses of 10, 20, 40 and 80 mg/kg p.o. pl showed a do ... | 2007 | 17499191 |
| piperlongumine, a constituent of piper longum l., inhibits rabbit platelet aggregation as a thromboxane a(2) receptor antagonist. | piper longum l. has been used as a crude drug for the treatment of the disorder of peripherally poor blood circulation in asia. in the present study, we examined the effect of piperlongumine, a constituent of p. longum l., on rabbit platelet aggregation. piperlongumine concentration-dependently inhibited platelet aggregation induced by thromboxane a(2) receptor agonist u46619, but it only slightly inhibited thrombin-induced one. piperlongumine also inhibited u46619-induced phosphatidylinositol h ... | 2007 | 17618620 |
| antiplatelet effects of acidamides isolated from the fruits of piper longum l. | the inhibitory effects of four acidamides, piperine, pipernonaline, piperoctadecalidine, and piperlongumine, isolated from the fruits of piper longum l. on washed rabbit platelet aggregation were examined. all of the four tested acidamides showed dose-dependent inhibitory activities on washed rabbit platelet aggregation induced by collagen, arachidonic acid (aa), and platelet-activating factor (paf), except for that induced by thrombin. piperlongumine, in particular, showed stronger inhibitory e ... | 2007 | 17689230 |
| antimutagenic effects of piperine on cyclophosphamide-induced chromosome aberrations in rat bone marrow cells. | piperine is a major pungent substance and active component of black pepper (piper nigrum linn.) and long pepper (piper longum linn.). both plants are used worldwide as household spices and condiments. they are also used as important ingredients in folklore medicine in many asian countries. therefore, it is of interest to study antimutagenic effects of piperine. in this study, its influence on chromosomes was investigated in rat bone marrow cells. male wistar rats were orally administered piperin ... | 2007 | 18260741 |
| piper longum linn. extract inhibits tnf-alpha-induced expression of cell adhesion molecules by inhibiting nf-kappab activation and microsomal lipid peroxidation. | recruitment of specific leukocyte subpopulations at the site of inflammation requires a series of cell adhesion molecule (cam)-mediated interactions. the major cams, viz., intercellular adhesion molecule-1 (icam-1), vcam-1 and e-selectin are expressed on endothelium in response to various cytokines or bacterial lps. here, we have evaluated the effect of piper longum chloroform extract (plce) on tnf-alpha-induced expression of icam-1 on endothelial cells and on nadph-catalyzed rat liver microsoma ... | 2008 | 17689945 |
| cytoprotective and immunomodulating properties of piperine on murine splenocytes: an in vitro study. | piper longum linn. and piper nigrum linn. are conventionally used as immuno-enhancers in indian system of traditional medicine. the underlying mechanism remains unknown. the present study was therefore, undertaken to delineate the role of piperine (major alkaloid) in cadmium (cd) induced immuno-compromised murine splenocytes. the various biological determinants such as oxidative stress markers (reactive oxygen species and gsh), bcl-2 protein expression, mitochondrial membrane potential, caspase- ... | 2007 | 17706638 |
| antiplatelet activities of newly synthesized derivatives of piperlongumine. | piperlongumine, a pyridone alkaloid isolated from piper longum l., exhibited a potential inhibitory effect on washed rabbit platelet aggregation induced by collagen, arachidonic acid (aa) and platelet activating factor (paf), without any inhibitory effect on that induced by thrombin. piperlongumine was used as a lead compound for the synthesis of new antiplatelet agents. seven synthetic compounds were newly synthesized from 3,4,5-trimethoxycinnamic acid (tmca). they were 1-piperidin-1-yl-3-(3,4, ... | 2008 | 18697182 |
| radioprotective potential of plants and herbs against the effects of ionizing radiation. | ionizing radiations produce deleterious effects in the living organisms and the rapid technological advancement has increased human exposure to ionizing radiations enormously. there is a need to protect humans against such effects of ionizing radiation. attempts to protect against the deleterious effects of ionizing radiations by pharmacological intervention were made as early as 1949 and efforts are continued to search radioprotectors, which may be of great help for human application. this revi ... | 2007 | 18188408 |
| alkamides from the fruits of piper longum and piper nigrum displaying potent cell adhesion inhibition. | eight alkamides 1-8 were isolated by bioassay-guided isolation of etoh extracts of the fruits of piper longum and piper nigum (piperaceae). their structures were elucidated by spectroscopic analysis ((1)h, (13)c nmr, and esi-ms) as follows: guineensine (1), retrofracamide c (2), (2e,4z,8e)-n-[9-(3,4-methylenedioxyphenyl)-2,4,8-nonatrienoyl]piperidine (3), pipernonaline (4), piperrolein b (5), piperchabamide d (6), pellitorin (7), and dehydropipernonaline (8). their compounds 3-5, 7, and 8 inhibi ... | 2008 | 18672369 |
| methylpiperate derivatives from piper longum and their inhibition of monoamine oxidase. | we have previously reported that piperine, a known piperidine alkaloid from piper longum, competitively inhibited mouse brain mao-a and mao-b activities. piperine also showed in vivo antidepressant-like activity against the tail suspension test. in the present study, we further expanded on the identification of mao inhibitors from the fruit of p. longum. activity-guided fractionation of a methylene chloride soluble extract led to the isolation of three known piperine-related compounds, methylpip ... | 2008 | 18563347 |
| antihyperlipidemic compounds from the fruit of piper longum l. | a bioassay-guided isolation of an ethanol extract of the fruit of piper longum l. yielded piperlonguminine, piperine and pipernonaline, as the main antihyperlipidemic constituents. they exhibit appreciable antihyperlipidemic activity in vivo, which is comparable to that of the commercial antihyperlipidemic drug, simvastatin. | 2009 | 19172581 |
| protective effect of piper longum l. on oxidative stress induced injury and cellular abnormality in adriamycin induced cardiotoxicity in rats. | effect of methanolic extract of fruits of p. longum (plm) on the biochemical changes, tissue peroxidative damage and abnormal antioxidant levels in adriamycin (adr) induced cardiotoxicity in wistar rats was investigated. plm was administered to wistar albino rats in two different doses, by gastric gavage (250 mg/kg and 500 mg/kg) for 21 days followed by ip adr (15 mg/kg) on 21st day. adr administration showed significant decrease in the activities of marker enzymes aspartate transaminase, alanin ... | 2008 | 18807757 |
| effect of piperine on the inhibition of nitric oxide (no) and tnf-alpha production. | effect of piperine which is an alkaloid present in plants such as piper nigrum and piper longum on the production of nitric oxide (no) and tumor necrosis factor-alpha (tnf-alpha) level was analyzed using in vitro as well as in vivo systems. the level of nitrite in the lps stimulated balb/c mice (95.3 microm) was reduced in the piperine treated animals (25 microm) significantly. nitrite level in the concanavalin-a (con-a) treated control animals (83.1 microm) was also significantly reduced to 18. ... | 2003 | 19180797 |
| protective effect of piper longum linn. on monosodium glutamate induced oxidative stress in rats. | protective effect of ethanol extract of piper longum linn. against monosodium glutamate (msg) induced toxicity was studied. rats, orally administered with msg at a dose of 8 mg/g body weight for 20 consecutive days, showed an increase in liver weight and rate of lipid peroxidation. glutathione (gsh) in serum, liver and kidney showed decreased concentration. significant increase was noticed in activities of serum alanine amino transferase (alt) and aspartate amino transferase (ast), levels of ser ... | 2009 | 19405384 |
| inhibitory effect of essential oils of allium sativum and piper longum on spontaneous muscular activity of liver fluke, fasciola gigantica. | effects of essential oil of allium sativum (garlic) and piper longum (indian long pepper) were evaluated on muscular activity of whole fasciola gigantica and its strip preparation. the whole flukes and longitudinal strip preparations of the flukes were isometrically mounted to record the spontaneous muscular activity (sma) and to evaluate effects of cumulative doses (0.1, 0.3, 1.0 and 3.0mg/ml) of the plant essential oils. whole flukes and the strip preparations exhibited continuous sma without ... | 2009 | 19679128 |
| studies on the neuroprotective role of piper longum in c6 glioma induced rats. | many naturally occurring substances of plant origin ingested in human diet, exhibit anticarcinogenic and antimutagenic effects. one of the active phytochemical which shows the active anticarcinogenic role is piper longum linn. (pl). pl is widely used in ayurvedic industry due to its property in healing some of the bodily ailments. despite being known for the antioxidant, antimicrobial and anticarcinogenic effects, its relation to brain and its tumour development is still scarce. hence, the exper ... | 2010 | 19730792 |
| stability-indicating reversed-phase liquid chromatographic methods for the determination of aconitine and piperine in a polyherbal formulation. | simple and rapid stability-indicating hplc methods were developed for the individual analysis of aconitine (acn) and piperine (pin) in mahamrutynjaya rasa, an herbal dosage form containing aconitum ferox, piper nigrum, and piper longum in combination. separation of the acn from its major and minor degradation products was successfully achieved on a reversed-phase c18 column (250 x 4.6 mm id, 5 microm particle size), with isocratic elution using a mixture of acetonitrile-kh2po4 buffer (10 mm, ph ... | 2009 | 19714970 |
| larvicidal potential of ethanolic extracts of dried fruits of three species of peppercorns against different instars of an indian strain of dengue fever mosquito, aedes aegypti l. (diptera: culicidae). | larvicidal bioassay was carried out in the laboratory to assess the potential of ethanolic extracts of dried fruits of three species of peppercorns: long pepper, piper longum l., black pepper, piper nigrum, and white pepper, piper nigrum against the different instars of field-collected indian strain of dengue fever mosquito (aedes aegypti l.). the investigations established the larvicidal potential of all the varieties of pepper fruits against ae. aegypti. against early fourth instar, the ethano ... | 2010 | 20549234 |
| inhibition of lipopolysaccharide-induced inflammatory responses by piperine. | piperine, a main component of piper longum linn. and piper nigrum linn., is a plant alkaloid with a long history of medical use. piperine exhibits anti-inflammatory activity; however, the underlying mechanism remains unknown. we examined the effects of piperine on lipopolysaccharide (lps)-induced inflammatory responses. administration of piperine inhibited lps-induced endotoxin shock, leukocyte accumulation and the production of tumor necrosis factor-alpha (tnf-alpha), but not of interleukin (il ... | 2010 | 20621590 |
| inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from piper longum on melanin production in b16 mouse melanoma cells. | an etoh extract of fruits of piper longum was found to exhibit a potent inhibitory effect against alpha-melanocyte-stimulating hormone (alpha-msh)-induced melanin production in b16 mouse melanoma cells. bioassay-directed fractionation led to the isolation of prenylated phenolic compounds bakuchiol, bavachin, and isobavachalcone. these compounds and the crude extract of the fruits of p. longum may have suppressive effects against pigmentation by melanin in the skin. | 2010 | 20622433 |
| safety of a novel botanical extract formula for ameliorating allergic rhinitis. | allergic rhinitis (also known as hay fever) is the most commonly occurring immunological disorder, and it affects 40 million men, women, and children in the united states. symptomatically, it is an inflammation and irritation of the mucous membranes that line the nose. allergy is defined as a state of hypersensitivity or hyperimmunity caused by exposure to a particular antigen (allergen) that results in increased reactivity upon subsequent exposure. a novel botanical formulation, aller-7/nr-a2, ... | 2003 | 20021150 |
| leishmania donovani: assessment of leishmanicidal effects of herbal extracts obtained from plants in the visceral leishmaniasis endemic area of bihar, india. | one obstacle faced in the effective control of visceral leishmaniasis (vl) is the limited number of available treatment options. furthermore, control efforts have been hindered further by the emergence of leishmania resistance to many of the available drugs. in this study, we investigated the anti-leishmanial properties of 30 medicinally important plants from the vl endemic area of bihar, india and compared them to two available anti-leishmanial drugs (sodium antimony gluconate and amphotericin ... | 2010 | 21070771 |
| antiinflammatory activity of piper longum fruit oil. | in the present study, antiinflammatory activity of the piper longum dried fruit's oil was studied in rats using the carrageenan-induced right hind paw edema method. the activity was compared with that of standard drug ibuprofen. the dried fruit's oil inhibited carrageenan-induced rat paw edema. the results indicated that the dried fruit's oil produced significant (p< 0.001) antiinflammatory activity when compared with the standard and untreated control. | 2009 | 20502557 |
| safety of a novel botanical extract formula for ameliorating allergic rhinitis. part ii. | abstract each year more than 50 million americans suffer from allergic rhinitis, which is a state of hypersensitivity or hyperimmunity. basically, allergic rhinitis is symptomatically recognized as the inflammation and irritation of the nasal mucosal membranes; sneezing; stuffy/runny nose; nasal congestion; and itchy; watery, and swollen eyes; and defined as a state of hypersensitivity/ hyperimmunity caused by exposure to a particular allergen (antigen) that results in increased reactivity upon ... | 2005 | 20021083 |
| paralytic effect of alcoholic extract of allium sativum and piper longum on liver amphistome, gigantocotyle explanatum. | to investigate the effects of alcoholic extract of allium sativum and piper longum on the muscular activity of a parasitic amphistome, gigantocotyle explanatum. | 2008 | 21279168 |
| the plant alkaloid piperine as a potential inhibitor of ethidium bromide efflux in mycobacterium smegmatis. | piperine, a major plant alkaloid found in black pepper (piper nigrum) and long pepper (piper longum), has shown potential for inhibiting the efflux pump (ep) of staphylococcus aureus. in this study, a modulation assay showed that piperine could decrease the mic of ethidium bromide (etbr) twofold at 32 μg ml(-1) and fourfold at 64 μg ml(-1) against mycobacterium smegmatis mc(2) 155 atcc 700084. a real-time, 96-well plate fluorometric method was employed to evaluate the ep inhibition ... | 2010 | 21051548 |
| two new amides with cytotoxic activity from the fruits of piper longum. | bioassay-guided fractionation of the fruits of piper longum afforded two new minor amides, piperlongimin a (2) [2e-n-isobutyl-hexadecenamide] and piperlongimin b (4) [2e-octadecenoylpiperidine] together with five known compounds with moderate cytotoxic activity. the structures were elucidated on the basis of spectroscopic evidences. all these compounds inhibited cell proliferation of human leukemia, hl-60 cell lines, and displayed major apoptosis-inducing effects. | 2011 | 21279878 |
| antibacterial activity of thai medicinal plants pikutbenjakul. | bacterial infections caused by resistant strains have been increased dramatically. pikutbenjakul, a thai medicinal plant formula containing piper longum, piper sarmentosum, piper interruptum, plumbago indica and zingiber officinale have been widely used in thai traditional medicine. | 2010 | 21298838 |
| studies on in vitro antioxidant and antistaphylococcal activities of some important medicinal plants. | oxidative stress is initiated by free radicals, which seek stability through electron pairing with biological macromolecules in healthy human cells and cause protein and dna damage along with lipid peroxidation. many phytochemicals have been found to play as potential antioxidants and antimicrobials. in the present study antioxidant and antistaphylococcal activities of bauhinia variegata, tinospora cardifolia and piper longum have been determined. total phenolic contents in plant extracts were e ... | 2011 | 21366958 |
| hepatoprotective action of ethanolic extracts of melia azedarach linn. and piper longum linn and their combination on ccl4 induced hepatotoxicity in rats. | a comparison of analysis in evaluating the hepatoprotective action of ethanolic extract of m. azedarach (mae) and p. longum (ple) with their combination biherbal extract (bhe) against carbon tetrachloride (ccl4) induced hepatic damage is reported in albino rats. there was a marked elevation of serum marker enzyme levels in ccl4 treated rats, which were restored towards normalization in the drug (mae and/or ple:50 mg/kg body weight po, once daily for 14 days) treated animals. the biochemical para ... | 2011 | 21614891 |
| immunomodulatory role of piperine in cadmium induced thymic atrophy and splenomegaly in mice. | cadmium being a potent immunotoxicant, affects both humoral and cell mediated immunity. in rodents, it is primarily characterized by marked thymic atrophy and splenomegaly. cadmium induces apoptosis in mice and suppresses the immune functions. piperine, major alkaloid of piper longum linn. and piper nigrum linn. with a long history of medicinal value, has shown anti-apoptotic activity in vitro. thus, to delineate its role in vivo, piperine (2.5mg/kg/day, oral, 7 days) treated balb/c mice were ad ... | 2009 | 21783982 |
| piperine production by endophytic fungus periconia sp. isolated from piper longum l. | the endophytic fungus periconia sp. produces piperine (5-(3, 4-methylenedioxyphenyl)-1-piperidinopent-2, 4-dien-1-one) under liquid culture. this is the first report of the alternative source for this chemical other than its host, piper longum. the highly functionalized fungus-derived piperine exhibits strong antimycobacterial activity against mycobacterium tuberculosis and m. smegmetis with minimum inhibitory concentrations of 1.74 and 2.62 μg ml(-1), respectively. the compound was crystallized ... | 2011 | 21505472 |
| a modified formulation of chinese traditional medicine improves memory impairment and reduces aß level in the tg-appswe/ps1de9 mouse model of alzheimer's disease. | ethnopharmacological relevance: suhexiang wan (shxw), a chinese traditional medicine has been used orally for the treatment of seizures, infantile convulsion, stroke and so forth. previously, we reported the effects of modified shxw essential oil mixture of the fragrance containing herbs on the sedative effect, anticonvulsant property and antioxidative activity after fragrance inhalation. materials and methods: this study was undertaken to evaluate beneficial effects of a modified recipe of shxw ... | 2011 | 21762767 |
| Simultaneous UFLC-ESI-MS/MS determination of piperine and piperlonguminine in rat plasma after oral administration of alkaloids from Piper longum L.: application to pharmacokinetic studies in rats. | The alkaloids from Piper longum L. showed protective effects on Parkinson's disease models in our previous study and piperine and piperlonguminine were the two main constituents in the alkaloids. The present study aimed at developing a rapid, sensitive, and accurate UFLC-ESI-MS/MS method and validating it for the simultaneous determination of piperine and piperlonguminine in rat plasma using terfenadine as the internal standard. The analytes and internal standard (IS) were extracted from rat pla ... | 2011 | 21903488 |
| piperine ameliorates the severity of cerulein-induced acute pancreatitis by inhibiting the activation of mitogen activated protein kinases. | piperine is a phenolic component of black pepper (piper nigrum) and long pepper (piper longum), fruits used in traditional asian medicine. our previous study showed that piperine inhibits lipopolysaccharide-induced inflammatory responses. in this study, we investigated whether piperine reduces the severity of cerulein-induced acute pancreatitis (ap). administration of piperine reduced histologic damage and myeloperoxidase (mpo) activity in the pancreas and ameliorated many of the examined labora ... | 2011 | 21663734 |
| anti-inflammatory activity of two varieties of pippali (piper longum linn.). | the present study has beenundertaken to evaluate the anti-inflammatory activity of two varieties of pippali in acute and sub-acute experimental models of inflammation in albino rats. four different market samples of each variety of pippali were procured from different regions of india. the samples collected from south india which have given more extractive values were selected for screening of anti-inflammatory activity. randomly selected animals were divided into four groups of six animals each ... | 2012 | 23559810 |
| assessment of anti-quorum sensing activity for some ornamental and medicinal plants native to egypt. | this study investigated the effects of some plant extracts on the bacterial communication system, expressed as quorum sensing (qs) activity. quorum sensing has a directly proportional effect on the amount of certain compounds, such as pigments, produced by the bacteria. alcohol extracts of 23 ornamental and medicinal plants were tested for anti-qs activity by the chromobacterium violaceum assay using the agar cup diffusion method. the screening revealed the anti-qs activity of six plants; namely ... | 2012 | 23641343 |
| computational drug target screening through protein interaction profiles. | the development of computational methods to discover novel drug-target interactions on a large scale is of great interest. we propose a new method for virtual screening based on protein interaction profile similarity to discover new targets for molecules, including existing drugs. we calculated target interaction profile fingerprints (tipfs) based on chembl database to evaluate drug similarity and generated new putative compound-target candidates from the non-intersecting targets in each pair of ... | 2016 | 27845365 |
| histochemical visualization of ros and antioxidant response to viral infections of vegetable crops grown in azerbaijan. | extremes of environmental conditions, such as biotic stresses, strongly affect plant growth and development and may adversely affect photosynthetic process. virus infection is especially problematic in crops, because unlike other diseases, its impact cannot be reduced by phytosanitary treatments. the vegetable crops (solanum lycopеrsicum l, cucurbita melo l., cucumis sativus l., piper longum l., solánum melongéna l., vicia faba l.) showing virus-like symptoms were collected from fields located i ... | 2014 | 24661407 |
| osmoregulatory and tegumental ultrastructural damages to protoscoleces of hydatid cysts echinococcus granulosus induced by fungal endophytes. | characteristic ultrastructural changes were observed when protoscoleces of hydatid cysts echinococcus granulosus was treated with extract of endophytic fungi eupenicillium and chaetomium sp. isolated from azadirachta indica and piper longum plants respectively. a sharp decrease in viability of protoscoleces was observed after 6 h of incubation with fungal extracts. the ultrastructural changes included rosteller disorganization, loss of hooks and shedding of the microtriches of scolex region. the ... | 2014 | 25320499 |
| effect of selected antiasthmatic plant constituents against micro organism causing upper respiratory tract infection. | most exacerbations of asthma can be proven to be associated with bacterial infections and there is scientific evidence that frequent respiratory infections particularly bacterial infections provoke asthma attack. considering these facts different plant extracts and phytoconstituents with proven anti asthmatic property had been selected for screening anti microbial activity in in-vitro models. in the present study, coleus forskohlii willd. extract (10% forskolin), piper longum l. extract (20% pip ... | 2010 | 22557357 |
| anti-hbv active constituents from piper longum. | in the screening search for hepatitis b virus inhibitory agents from medicinal plants, the ethanol extract of piper longum linn. was found to possess superior anti-hbv activity in vitro. bioassay-guided fractionation coupled with repeated purification resulted in the isolation of four new compounds, involving two new glycosides longumosides a (1) and b (2) and two new amide alkaloids erythro-1-[1-oxo-9(3,4-methylenedioxyphenyl)-8,9-dihydroxy-2e-nonenyl]-piperidine (3), threo-1-[1-oxo-9(3,4-methy ... | 2013 | 23434420 |
| piperlongumine inhibits lmp1/myc-dependent mouse b-lymphoma cells. | piperlongumine (pl), isolated from the fruit of long pepper, piper longum, is a cancer-inhibiting compound that selectively kills tumor cells while sparing their normal counterparts. here we evaluated the efficacy with which pl suppresses malignant b cells derived from a newly developed, double-transgenic mouse model of human endemic burkitt lymphoma (bl), designated mcd40-lmp1/imyc(eμ). pl inhibited tumor cell proliferation in a concentration-dependent manner and induced apoptosis of neoplastic ... | 2013 | 23764397 |
| leishmania donovani pteridine reductase 1: comparative protein modeling and protein-ligand interaction studies of the leishmanicidal constituents isolated from the fruits of piper longum. | visceral leishmaniasis or kala-azar is caused by the dimorphic parasite leishmania donovani in the indian subcontinent. treatment options for kala-azar are currently inadequate due to various limitations. currently, drug discovery for leishmaniases is oriented towards rational drug design; the aim is to identify specific inhibitors that target particular metabolic activities as a possible means of controlling the parasites without affecting the host. leishmania salvages pteridin from its host an ... | 2012 | 22752544 |
| leishmanicidal compounds from the fruits of piper longum. | one new alkaloid amide, piperlongumide (1) [n-isobutyl-19-(3',4'-methylenedioxyphenyl)-2e,4e nonadecadienamide], and six known compounds with leishmanicidal activity against promastigotes and axenic amastigotes of leishmania donovani were isolated from the n-hexane fraction of the fruits of piper longum. the structure of 1 was elucidated by spectroscopic evidences. | 2012 | 22576441 |
| isolation and characterization of antidermatophytic bioactive molecules from piper longum l. leaves. | piper longum l. (piperaceae) commonly known as "long pepper" is a well known medicinal plant in ayurveda. different parts of this plant, such as root, seed, fruit, whole plant etc. are used traditionally in various ailments. here we have investigated the antidermatophytic activity of sequentially extracted petroleum ether, chloroform, methanol and water extracts from p. longum leaf against trichophyton mentagrophytes, t. rubrum, t. tonsurans, microsporum fulvum and m. gypseum. better activity of ... | 2012 | 24293721 |
| experimental evaluation of antipyretic and analgesic activities of amalakyadi gana: an ayurvedic formulation. | in ayurvedic classics, the symptom fever is considered as a separate disease called jwara. acharya sushruta has mentioned amalakyadi gana for treatment of all types of jwara, which contains four drugs namely amalaki (emblica officinalis gaertn.), haritaki (terminalia chebula retz.), pippali (piper longum l.), and chitraka (plumbago zeylenica l.). | 2017 | 27011727 |
| larvicidal effect of pepper plants on aedes aegypti (l.) (diptera: culicidae). | ethanolic extracts derived from three species of the piperaceae (pepper) family, piper longum l., p. ribesoides wall., and p. sarmentosum roxb. ex hunt., were evaluated for efficacy against early 4th instar larvae of aedes aegypti mosquitoes using larvicidal bioassays. the highest larvicidal efficacy was established from p. longum, followed by p. sarmentosum and p. ribesoides, with lc50 values of 2.23, 4.06, and 8.13 ppm, respectively. observations of morphological alterations on treated 4th ins ... | 2006 | 16859102 |