| acute bovine pulmonary emphysema produced by perilla frutescens. | | 1978 | 568714 |
| perilla ketone: a potent lung toxin from the mint plant, perilla frutescens britton. | perilla ketone, from the essential oil of perilla frutescens, is a potent pulmonary edemagenic agent for laboratory animals and livestock. this finding would account for reported effects of the plant on grazing cattle. the use of perilla in oriental foods and medicinal preparations suggests possible hazards to human health as well. | 1977 | 877573 |
| [comparison of bacteriostatic ability of oleum of perilla frutescens (l.) britt., cinnamomum cassia presl and nipagin a]. | a comparison of bacteriostatic ability has been carried out among oleum of perilla frutescens and cinnamomum cassia, benzoic acid and nipagin a. the result shows that the inhibiting effect of perilla frutescens and cinnamomum cassia on microorganisms inoculated and spontaneously contaminated is similar to or obviously superior to nipagin a and benzoic acid. | 1990 | 2390180 |
| intoxication of cattle by perilla frutescens (purple mint). | perilla frutescens or purple mint has been associated with atypical interstitial pneumonia (aip) for a quarter of a century. the amount and the stage of the plant required to produce aip have been much debated. a field case in which catastrophic loses occurred in cattle ingesting hay containing purple mint showed that more than the green plants have the capability of producing atypical interstitial pneumonia. in this study, perilla frutescens produced atypical interstitial pneumonia in three of ... | 1986 | 3776081 |
| inhibitory effects of perillosides a and c, and related monoterpene glucosides on aldose reductase and their structure-activity relationships. | monoterpene glucosides, perillosides a and c, obtained from the leaves of perilla frutescens, were found to be inhibitors of aldose reductase (ec 1.1.1.21) which is considered to be a key enzyme in diabetic complications such as cataract. the apparent type of inhibition of rat lens aldose reductase by perillosides a and c was competitive with respect to glyceraldehyde and their k(i) values were 1.4 x 10(-4) and 2.3 x 10(-4) m, respectively. the type of inhibition by their tetraacetates was non-c ... | 1995 | 7641310 |
| cdna cloning, characterization, and functional expression of 4s-(-)-limonene synthase from perilla frutescens. | a molecular biological study on limonene synthase that catalyzes the cyclization of geranyldiphosphate to yield the olefin 4(s)-limonene, an intermediate in the biosynthesis of a monoterpenoid, perillaldehyde, in perilla frutescens britton has been carried out. we isolated and characterized 10 cdnas homologous to spearmint limonene synthase cdna from an expression library constructed from cotyledons of a perilla strain homozygous for two pairs of dominant genes, g and h, which are responsible fo ... | 1996 | 8806736 |
| anti-hiv-1 activity of herbs in labiatae. | the anti-hiv-1 activity of aromatic herbs in labiatae was evaluated in vitro. forty five extract from among 51 samples obtained from 46 herb species showed significant inhibitory effects against hiv-1 induced cytopathogenicity in mt-4 cells. in particular, the aqueous extracts of melissa officinalis, a family of mentha x piperita "grapefruit mint," mentha x piperita var. crispa, ocimum basilicum cv "cinnamon," perilla frutescens var. crispa f. viridis, prunella vulgaris subsp. asiatica and satur ... | 1998 | 9743251 |
| molecular cloning and biochemical characterization of a novel anthocyanin 5-o-glucosyltransferase by mrna differential display for plant forms regarding anthocyanin. | udp-glucose: anthocyanin 5-o-glucosyltransferase (5-gt) is responsible for the modification of anthocyanins to more stable molecules in complexes for co-pigmentation, supposedly resulting in a purple hue. the cdna encoding 5-gt was isolated by a differential display applied to two different forms of anthocyanin production in perilla frutescens var. crispa. differential display was carried out for mrna from the leaves of reddish-purple and green forms of p. frutescens, resulting in the isolation ... | 1999 | 10066805 |
| direct evidence for anthocyanidin synthase as a 2-oxoglutarate-dependent oxygenase: molecular cloning and functional expression of cdna from a red forma of perilla frutescens. | anthocyanidin synthase (ans), an enzyme of the biosynthetic pathway to anthocyanin, has been postulated to catalyze the reaction(s) from the colorless leucoanthocyanidins to the colored anthocyanidins. although cdnas have been isolated that encode putative ans, which exhibits significant similarities in amino acid sequence with members of a family of 2-oxoglutarate-dependent oxygenases, no biochemical evidence has been presented which identifies the actual reaction that is catalyzed by ans. here ... | 1999 | 10074715 |
| the cyanogenic glucoside, prunasin (d-mandelonitrile-beta-d-glucoside), is a novel inhibitor of dna polymerase beta. | a dna polymerase beta (pol. beta) inhibitor has been isolated independently from two organisms; a red perilla, perilla frutescens, and a mugwort, artemisia vulgaris. these molecules were determined by spectroscopic analyses to be the cyanogenic glucoside, d-mandelonitrile-beta-d-glucoside, prunasin. the compound inhibited the activity of rat pol. beta at 150 microm, but did not influence the activities of calf dna polymerase alpha and plant dna polymerases, human immunodefficiency virus type 1 r ... | 1999 | 10423540 |
| a light-inducible myb-like gene that is specifically expressed in red perilla frutescens and presumably acts as a determining factor of the anthocyanin forma. | the myb-p1 gene was isolated by screening for differentially expressed myb-related genes in red (anthocyanin-producing) and green (anthocyanin nonproducing) forms of perilla frutescens. expression of myb-p1 is increased 10-fold in the red relative to the green form of p. futescens, and the gene is induced by light. myb-p1 has only one dna-binding region, which corresponds to repeat iii in the general structure of myb proteins. in the yeast two-hybrid system, it was shown that myb-p1 interacted w ... | 1999 | 10503537 |
| a constitutively expressed myc-like gene involved in anthocyanin biosynthesis from perilla frutescens: molecular characterization, heterologous expression in transgenic plants and transactivation in yeast cells. | the coordinate expression of anthocyanin biosynthetic genes in leaves and stems of a red forma of perilla frutescens is presumably controlled by regulatory gene(s). a myc-like gene (myc-rp) was isolated from a cdna library prepared from the leaves of red p. frutescens, and its deduced amino acid sequence shows 64% identity with that of delila from snapdragon. the myc-rp gene was expressed in leaves and roots of both red and green p. frutescens equally. comparison of deduced amino acid sequence o ... | 1999 | 10561066 |
| glycoprotein derived from the hot water extract of mint plant, perilla frutescens britton. | glycoprotein showing inhibitory activity against mast cell degranulation and hyaluronidase activity was purified from the hot water extract of mint plant (perilla frutescens britton). the purified inhibitor gave a single band detected with coomassie brilliant blue staining and periodic acid-schiff staining on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page) analysis. the molecular mass was estimated to be 6.0 kda on sds-page. the inhibitor did not become inactivated when boil ... | 1999 | 10563918 |
| [pharmacological effects of zisu and baisu]. | the extract and volatile oil of zisu (perilla frutescens) has shown significant antipyretic effect in rabbits and antiemetic effect in pigeons. the fatty oil extracted from its seeds has significant antitussive effect in mice and anti-asthmatic effect in guinea pigs. the extract, volatile oil and fatty oil of baisu, which is of the same genus as zisu have the same effects as those of zisu. the acute toxicities of the extract and fatty oil of zisu and baisu, whether by peroral or by intraperitone ... | 1997 | 10683915 |
| metabolites of orally administered perilla frutescens extract in rats and humans. | as a part of our search for bioactive substances from the leaves of perilla frutescens britton var. acuta kudo (perillae herba, labiatae), the aqueous extract was orally administered to rats and humans, and metabolites in the urine, plasma, and/or bile were analyzed by a high-performance liquid chromatograph (hplc) equipped with a photodiode array detector. when the extract was administered to rats, 10 metabolites, trans-caffeic acid-4-o-sulfate (1), trans-p-coumaric acid-4-o-sulfate (2), trans- ... | 2000 | 10706426 |
| two new prenylated 3-benzoxepin derivatives as cyclooxygenase inhibitors from perilla frutescens var. acuta. | two novel prenyl 3-benzoxepin derivatives, perilloxin (1) and dehydroperilloxin (2), were isolated from the dichloromethane extract of the stems of perilla frutescens var. acuta. their structures were elucidated as (-)-(r)-5-methoxy-2,3-dihydrofuro[2, 3-g][3]benzoxepin and 5-methoxyfuro[2,3-g][3]benzoxepin, respectively, based on uv, ms, (1)h and (13)c nmr, noe, (1)h-(13)c cosy, and hmbc spectral data. they were isolated following bioassay-guided fractionation, using an in vitro cyclooxygenase-1 ... | 2000 | 10757731 |
| molecular and biochemical characterization of a novel hydroxycinnamoyl-coa: anthocyanin 3-o-glucoside-6"-o-acyltransferase from perilla frutescens. | we have isolated and characterized a cdna, pfat208, encoding hydroxycinnamoyl-coa: anthocyanin 3-o-glucoside-6"-o-acyltransferase (3at) from perilla frutescens. the identity of the cdna was established by determination of the reaction products with recombinant enzyme overexpressed in escherichia coli. the deduced amino acid sequence has a few regions that are conserved in a coa-dependent acyltransferase family. the recombinant enzyme produced in yeast could utilize cyanidin 3-glucoside and cyani ... | 2000 | 10845463 |
| inhibitory effect of mast cell-mediated immediate-type allergic reactions in rats by perilla frutescens. | we investigated the effect of aqueous extract of perilla frutescens (labiatae) (pfae) on the mast cell-mediated immediate-type allergic reactions. pfae (0.05 to 1 g/kg) dose-dependently inhibited systemic allergic reaction induced by compound 48/80 in rats. pfae (0.1 and 1 g/kg) also significantly inhibited local allergic reaction activated by anti-dnp ige. when pfae was pretreated at the same concentrations with systemic allergic reaction test, the plasma histamine levels were reduced in a dose ... | 2000 | 10946827 |
| molecular cloning and functional expression of perilla frutescens 3-ketoacyl-(acyl carrier protein) synthase iii. | the 3-ketoacyl-acyl carrier protein synthase iii (kas iii) is a condensing enzyme catalyzing the initial step of fatty acid biosynthesis. we isolated two kas iii cdna isoforms (pfkas3a and pfkas3b) from a cdna library specific to perilla frutescens immature seeds. two cdnas coded for 401 and 400 amino acids, respectively, which showed high degree of sequence similarity to corresponding enzymes from various sources. results of southern hybridization indicated that the pfkas3a gene is present as t ... | 2000 | 10987132 |
| antidepressant effects of banxia houpu decoction, a traditional chinese medicinal empirical formula. | banxia houpu decoction, having been used for the treatment of depression-related diseases since ancient times, is a traditional chinese medicinal empirical formula consisting of pinellia ternata, poria cocos, magnolia officinalis, perilla frutescens and zingiber officinale. the effects of the total decoction extract and five fractions therefrom, were evaluated in mice by tail suspension and forced swimming tests. the total 90% ethanol extract of the decoction was shown to possess an antidepressa ... | 2000 | 11025166 |
| molecular cloning and expression analysis of 3-ketoacyl-acp synthases in the immature seeds of perilla frutescens. | we report the isolation and expression analysis of two cdnas encoding 3-ketoacyl-acyl carrier protein synthases (kas) that are involved in the de novo synthesis of fatty acids in plastids of perilla (perilla frutescens l.). the cdnas, designated pffab1 and pffab24, encoded polypeptides with high sequence identities to those of kas i and kas ii/iv, respectively, of various plants. genomic southern blots revealed that there was a single pffab1 gene but two pffab24 genes in the perilla genome. of i ... | 2000 | 11101144 |
| suppressive effects of perilla frutescens on mesangioproliferative glomerulonephritis in rats. | leaves of perilla frutescens var. crispa decne. (perilla, labiatae) are used as a garnishing vegetable in east asian countries as well as an herbal medicine prescribed in kampo medicines such as saiboku-to. a previous in vitro study revealed that a decoction of perilla leaves inhibits the proliferation of murine-cultured mesangial cells. in the present study, we evaluated the in vivo anti-proliferative effects of a perilla decoction using rat mesangio-proliferative glomerulonephritis induced by ... | 2001 | 11217087 |
| transcriptional expression characteristics and subcellular localization of adp-glucose pyrophosphorylase in the oil plant perilla frutescens. | three adp-glucose pyrophosphorylase clones were isolated from the cotyledon cdna library of the oil plant, perilla frutescens, and their intracellular localization investigated. two of three cdnas (pfagps1 and pfagps2) were homologous to the catalytic small subunit of agpases found in other plants, while the third clone (pfagpl) was highly similar to the large subunit type. transcripts for pfagps1 and pfagps2 were observed in both photosynthetic and non-photosynthetic tissue, showing the highest ... | 2001 | 11230568 |
| differential expression of two cytochrome p450s involved in the biosynthesis of flavones and anthocyanins in chemo-varietal forms of perilla frutescens. | in perilla frutescens, there are two varietal forms of anthocyanin accumulation, i.e. red and green forms. the cdna clones encoding flavone synthase ii (fsii) and flavonoid 3'-hydroxylase (f3'h), two cytochrome p450s that are involved in the biosynthesis of flavones and anthocyanins, were isolated from p. frutescens. the fsii cdna encoded a 57.1 kda protein designated as cyp93b6, and the f3'h cdna encoded 57.5 kda protein designated as cyp75b4. recombinant cyp93b6 expressed in yeast converted fl ... | 2001 | 11773526 |
| two neolignans from perilla frutescens and their inhibition of nitric oxide synthase and tumor necrosis factor-alpha expression in murine macrophage cell line raw 264.7. | two neolignans were isolated from leaves of perilla frutescens (labiatae) as inhibitors of nitric oxide syntheses (ic50 5.9 microm and 53.5 microm, respectively) and tumor necrosis factor-alpha in lipopolysaccharide-activated raw 264.7 cells. their structures were identified as 1beta,2alpha,3beta,4alpha-1,2-dimethyl-3,4-bis-(2,4,5-trimethoxyphenyl)-cyclobutane (magnosalin), and 1alpha,2beta,3beta,4alpha-1,2-dimethyl-3,4-bis-(2,4,5-trimethoxyphenyl)-cyclobutane (andamanicin), and their activities ... | 2002 | 11844692 |
| two flavonoid glucosyltransferases from petunia hybrida: molecular cloning, biochemical properties and developmentally regulated expression. | two flavonoid glucosyltransferases, udp-glucose:flavonoid 3-0-glucosyltransferase (3-gt) and udp-glucose: anthocyanin 5-o-glucosyltransferase (5-gt), are responsible for the glucosylation of anthocyani(di)ns to produce stable molecules in the anthocyanin biosynthetic pathway. the cdnas encoding 3-gt and 5-gt were isolated from petunia hybrida by hybridization screening with heterologous probes. the cdna clones of 3-gt, pgt8, and 5-gt, ph1, encode putative polypeptides of 448 and 468 amino acids, ... | 2002 | 11905966 |
| effect of perilla frutescens on nitric oxide production and dna synthesis in cultured murine vascular smooth muscle cells. | the effects of perilla (perilla frutescens, labiatae) on murine cultured vascular smooth muscle cells (vsmc) were investigated. the water extract of perilla leaves induced nitric oxide (no) production of vsmc and this effect was synergistically augmented when combined with interferon (ifn)-gamma or tumour necrosis factor (tnf)-alpha, while the perilla extract significantly inhibited no production induced by ifn-gamma combined with lipopolysaccharide (lps). northern blot analysis revealed that th ... | 2002 | 11933134 |
| influence of dietary supplementation of herb extracts on volatile sulfur production in pig large intestine. | volatile sulfur compounds (vs) are generated in the large intestine by the bacterial metabolism of sulfate and sulfur amino acids. vs are potentially harmful to the host. the effect of dietary supplementation of herb extracts on volatile sulfur production in the large intestine of pig was evaluated in this study. the extracts perilla frutescens (soyou), mentha piperita (peppermint), and ajuga decumbens (kiransou) were fed to pigs equipped with a permanent cannula at the cecum. cecal digesta were ... | 2002 | 12026183 |
| antimicrobial activity of perilla seed polyphenols against oral pathogenic bacteria. | a perilla seed (perilla frutescens britton var. japonica hara) extract was examined for its antimicrobial activity against oral cariogenic streptococci and periodontopathic porphyromonas gingivalis. luteolin, one of the components of perilla seed, showed the strongest antimicrobial effect among the phenolic compounds. according to our results, perilla seed may be the source of an antimicrobial agent that could prevent dental caries and periodontal diseases. | 2002 | 12036078 |
| rosmarinic acid and caffeic acid produce antidepressive-like effect in the forced swimming test in mice. | we previously showed that rosmarinic acid from the leaves of perilla frutescens britton var. acuta kudo (perillae herba) has antidepressive-like activity. the aim of the present study was to examine (i) whether caffeic acid, a major metabolite of rosmarinic acid, also has antidepressive-like activity, and (ii) whether these substances inhibit either the uptake of monoamines to synaptosomes or mitochondrial monoamine oxidase activity. rosmarinic acid (2 mg/kg, i.p.) and caffeic acid (4 mg/kg, i.p ... | 2002 | 12167468 |
| rosmarinic acid, a major polyphenolic component of perilla frutescens, reduces lipopolysaccharide (lps)-induced liver injury in d-galactosamine (d-galn)-sensitized mice. | the protective activity of rosmarinic acid from perilla frutescens on liver injury induced by lps in d-galn-sensitized mice was examined. we also investigated the effects of antitumor necrosis factor-alpha antibody (anti-tnf), superoxide dismutase (sod), and aminoguanidine (ag) on this model in order to elucidate the mechanism of rosmarinic acid protection. perilla extract (pe) and rosmarinic acid (ra) treatments significantly reduced the elevation of plasma asparatate aminotransferase levels, a ... | 2002 | 12208367 |
| a wd-repeat-containing putative regulatory protein in anthocyanin biosynthesis in perilla frutescens. | the wd-repeat proteins are found in eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as signal transduction, transcription, and proliferation. in this study, we have isolated a cdna encoding a novel wd-repeat protein, pfwd, from the anthocyanin-pigmented leaves of perilla frutescens using an11 cdna from petunia hybrida as the probe. the c-terminal region of pfwd contains a wd repeat that is highly conserved in homologous proteins from a variety ... | 2002 | 12369624 |
| [supercritical-co2 fluid extraction of fatty oils from perilla frutescens seeds and pharmacological study]. | fatty oils from the seeds of perilla frutescens were extracted by supercritical-co2 fluid or petroleum ether and its quality was analyzed by gc-ms method. pharmacological action of lowering blood-lipid for the oils was studied. the results showed that the technology of supercritical-co2 extraction of the oils of p. frutescens seeds is superior than that of petroleum ether and the oil from sfe-co2 have the action of lowering blood-lipid with low toxicity. | 1999 | 12571915 |
| a novel substance purified from perilla frutescens britton inhibits an early stage of hiv-1 replication without blocking viral adsorption. | pf-gp6, a 6 kda anti-degranulation glycoprotein purified from the extract of perilla frutescens, was examined for its antiviral activity against hiv-1 and hiv-2 in vitro. hiv-1-induced cytopathic effect and proviral dna synthesis were inhibited in the presence of pf-gp6. the 50% inhibitory concentrations of pf-gp6 for various hiv-1 strains, including clinical isolates and ccr5-using (r5) hiv-1, ranged between 1.3 and 71.0 microg/ml, depending on the combination of viral strain and host cell. fur ... | 2002 | 12630676 |
| antidepressant-like effects of apigenin and 2,4,5-trimethoxycinnamic acid from perilla frutescens in the forced swimming test. | we studied the effects of apigenin and 2,4,5-trimethoxycinnamic acid (tmca) on the behavioral despair test (forced swimming test), and the central noradrenergic, dopaminergic and serotonergic activities in mice. apigenin at intraperitoneal doses of 12.5 and 25 mg/kg significantly decreased the duration of immobility in the forced swimming test in mice. at 100 mg/kg, the duration of immobility was returned to the control level in the test. on the other hand, tmca treatment (25-200 mg/kg, i.p.) fa ... | 2003 | 12673028 |
| limonene production in tobacco with perilla limonene synthase cdna. | limonene synthase (ls) catalyses the stereo-specific cyclization of geranyl diphosphate (gpp) to form a monocyclic monoterpene, limonene. in an attempt to engineer monoterpene biosynthesis, three expression constructs of ls cdna of perilla frutescens, which were designed to be localized in either the plastid, the cytosol or the endoplasmic reticulum (er), were introduced into tobacco in order to examine differences in enzyme activity and the productivity of limonene. high and moderate enzyme act ... | 2003 | 14585822 |
| rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of perilla frutescens extract in the murine two-stage skin model. | perilla frutescens extract showed marked reduction on tumorigenesis in a murine, two-stage skin carcinogenesis model. in this model, cancer is initiated by application of 7,12-dimethylbenz[a]anthracene (dmba) and promoted by application of 12-tetradecanoylphorbol 13-acetate (tpa). following tumor initiation with dmba, topical application of a perilla-derived fraction (pf) at doses of 2 mg/mouse/application resulted in significant inhibition of tumorigenesis. the efficacy of each fraction was cor ... | 2004 | 14729597 |
| triterpene acids from the leaves of perilla frutescens and their anti-inflammatory and antitumor-promoting effects. | nine triterpene acids, viz., six of the ursane type, ursolic acid (1), corosolic acid (2), 3-epicorosolic acid (3), pomolic acid (4), tormentic acid (5) and hyptadienic acid (6), and three of the oleanane type, oleanolic acid (7), augustic acid (8) and 3-epimaslinic acid (9), among which 1 constituted the most predominant triterpene acid, were isolated and identified from ethanol extracts of the leaves of red perilla [perilla frutescens (l.) britton var. acuta kudo] and green perilla [p. frutesc ... | 2004 | 14745168 |
| extract of perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans. | extract of perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, suppresses allergic immunoglobulin responses and inflammation caused by polymorphonuclear leukocytes (pmnl) in mice. however, few placebo-controlled clinical trials have examined the efficacy and safety of polyphenolic phytochemicals for treatment of allergic inflammatory diseases in humans. the present study determined whether oral supplementation with rosmarinic acid is an effective intervention for patie ... | 2004 | 14988517 |
| [common perilla (perilla frutescens (l.) britton.) as a perspective immunomodulator]. | common perilla (perilla frutescens (l.) britton) is a new perspective annual medicinal dead-nettle family (lamiaceae lindl.) plant in lithuania. its medicinal raw material and preparations produced of it are characterised by the variety of pharmacological effects: desensitizing, antimicrobial, anti tumorous, and antioxidative. this species was introduced from the east asia and cultivated in many european, asian, and north american countries. the common perilla has been cultivated in lithuania as ... | 2004 | 15064542 |
| effects of rosmarinic acid against aflatoxin b1 and ochratoxin-a-induced cell damage in a human hepatoma cell line (hep g2). | recent findings have suggested that oxidative damage might contribute to the cytotoxicity and carcinogenicity of aflatoxin b(1) (afb(1)). the induction of oxidative stress also plays an important role in the toxicity of another mycotoxin: ochratoxin a (ota). in this study, the protective effect of rosmarinic acid (ros a) against afb(1) and ota-induced cytotoxicity was investigated in a human hepatoma-derived cell line (hep g2). rosmarinic acid, a natural phenolic compound contained in many lamia ... | 2004 | 15300717 |
| agrobacterium-mediated genetic transformation of perilla frutescens. | a reproducible plant regeneration and an agrobacterium tumefaciens-mediated genetic transformation protocol were developed for perilla frutescens (perilla). the largest number of adventitious shoots were induced directly without an intervening callus phase from hypocotyl explants on ms medium supplemented with 3.0 mg/l 6-benzylaminopurine (ba). the effects of preculture and extent of cocultivation were examined by assaying beta-glucuronidase (gus) activity in explants infected with a. tumefacien ... | 2004 | 15368075 |
| paenibacillus elgii sp. nov., with broad antimicrobial activity. | two novel spore-forming bacteria with broad antimicrobial activity were isolated from roots of perilla frutescens. the isolates, sd17(t) and sd18, were facultatively anaerobic and showed variable gram reaction. growth was observed between 20 and 45 degrees c. dna g+c content of sd17(t) was 51.7 mol%, and the major fatty acid was anteiso-c(15 : 0) (54.1 %). 16s rrna gene sequence similarity of sd17(t) ranged from 98.6 to 91.3 % with other paenibacillus species. the phylogenetic tree showed that i ... | 2004 | 15545429 |
| cdna isolation and functional expression of myrcene synthase from perilla frutescens. | cdna cloning of a monoterpene synthase from perilla frutescens whose steam-distilled oil contains 92.9% perillaketone, was performed by the pcr method using primers designed based on limonene synthase. the full-length nucleotide sequence of this cdna consisted of 1978 bp including a 1827-bp translational region encoding a deduced protein of 608 amino acids, which was similar to that of limonene synthase from p. frutescens (85% identity). functional expression of this clone in escherichia coli yi ... | 2004 | 15577217 |
| mechanisms of relaxant action of luteolin in isolated guinea pig trachea. | we have investigated the mechanisms of action of luteolin, a flavone found in perilla frutescens, a chinese herbal medicine for treating asthma. in fact, luteolin occurs mostly as a glycoside in many plant species. the tension changes of tracheal segments were isometrically recorded on a polygraph. luteolin concentration-dependently relaxed histamine (30 microm)-, carbachol (0.2 microm)- and kcl (30 mm)-induced precontractions, and inhibited cumulative histamine- and carbachol-induced contractio ... | 2005 | 15931576 |
| vasodilative effect of perillaldehyde on isolated rat aorta. | the vasodilative effect of perillaldehyde, one of the major oil components in perilla frutescens britton, was studied using isolated rat aorta. perillaldehyde at final concentrations of 0.01 to 1 mm showed dose-dependent relaxation of the aorta contracted by treatment with prostaglandin f2alpha or norepinephrine. neither the presence of ng-nitro-l-arginine methyl ester nor removal of the aortic endothelium affected the vasodilatation, suggesting that perillaldehyde exerts a direct effect on vasc ... | 2005 | 15957366 |
| rosmarinic acid inhibits the formation of reactive oxygen and nitrogen species in raw264.7 macrophages. | antioxidant action of rosmarinic acid (ros a), a natural phenolic ingredient in many lamiaceae herbs such as perilla frutescens, sage, basil and mint, was analyzed in relation to the ikappa-b activation in raw264.7 macrophages. ros a inhibited nitric oxide (no) production and inducible nitric oxide synthase (inos) protein synthesis induced by lipopolysaccharide (lps), and also effectively suppressed phorbol 12-myristate 13-acetate (pma)-induced superoxide production in raw264.7 macrophages in a ... | 2005 | 16087481 |
| inhibitory effects of rosmarinic acid on adriamycin-induced apoptosis in h9c2 cardiac muscle cells by inhibiting reactive oxygen species and the activations of c-jun n-terminal kinase and extracellular signal-regulated kinase. | rosmarinic acid (ra) is a naturally occurring polyphenolic and is found in several herbs in the lamiaceae family, such as, perilla frutescens. adr is a potent anti-tumor drug, but is unfortunately potently cardiotoxic. this study was undertaken to investigate the inhibitory effect of ra on adr-induced apoptosis in h9c2 cardiac muscle cells at a mechanistic level. in vitro, adr significantly decreased the viabilities of h9c2 cells, and this was accompanied by apoptotic features, such as a change ... | 2005 | 16102732 |
| isolation and characterization of anthocyanin 5-o-glucosyltransferase in perilla frutescens var. crispa by differential display. | the glucosylation of 5-position of anthocyanin molecules is one of most important modification step, which is responsible for the stability and color hue of anthocyanin molecules. however, anthocyanin 5-o-glucosyltransferase (5-gt) is unstable and it had been difficult to purify this enzyme by biochemical methods. the isolation of cdna encoding 5-gt was succeeded first by mrna differential display (dd) of red and green chemotypes of perilla frutescens var. crispa. the full-length cdna was isolat ... | 2006 | 16264234 |
| [the influence of common perilla (perilla frutescens (l.) britton) on non-specific cell-mediated immunity--phagocytosis activity]. | to examine the effect of plant preparations, obtained from perilla frutescens (l.) britton introduced in lithuania, on non-specific cell-mediated immunity. | 2005 | 16401961 |
| detection of 4-oxo-2-hexenal, a novel mutagenic product of lipid peroxidation, in human diet and cooking vapor. | since the diet plays an important role in the development of human cancer, it is important to identify mutagens in foods. we have detected a novel mutagenic product, 4-oxo-2-hexenal (4-ohe), in a model lipid peroxidation reaction mixture [h. kasai, m. maekawa, k. kawai, k. hachisuka, y. takahashi, h. nakamura, r. sawa, s. matsui, t. matsuda, 4-oxo-2-hexenal, a mutagen formed by omega-3 fat peroxidation, causes dna adduct formation in mouse organs, ind. health 43 (2005) 699-701]. in the present s ... | 2006 | 16423557 |
| inotropic and lusitropic effects of perilla frutescens (l.) britton extract on the rabbit myocardium. | common perilla (perilla frutescens (l.) britton) is a plant cultivated in many countries around the world. although its immunomodulating and antioxidative properties are well known, there is a lack of data about the cardiotropic activity of the plant. the objective of this study was to determine the influence of perilla frutescens extract on the myocardial contractility in vitro and as a food supplement in vivo. | 2006 | 16778469 |
| directed evolution of plant basic helix-loop-helix transcription factors for the improvement of transactivational properties. | myc-rp from perilla frutescens and delila from antirrhinum majus, two plant basic helix-loop-helix transcription factors (bhlh tfs) involved in the flavonoid biosynthetic pathway, have been used for the improvement of transactivational properties by directed evolution. through two rounds of dna shuffling, myc-rp variants with up to 70-fold increase in transcriptional activities have been identified using a yeast transactivation system. in a tobacco protoplast transient expression assay, one of t ... | 2006 | 16837081 |
| increased alpha-tocopherol content in soybean seed overexpressing the perilla frutescens gamma-tocopherol methyltransferase gene. | tocopherols, with antioxidant properties, are synthesized by photosynthetic organisms and play important roles in human and animal nutrition. in soybean, gamma-tocopherol, the biosynthetic precursor to alpha-tocopherol, is the predominant form found in the seed, whereas alpha-tocopherol is the most bioactive component. this suggests that the final step of the alpha-tocopherol biosynthetic pathway catalyzed by gamma-tocopherol methyltransferase (gamma-tmt) is limiting in soybean seed. soybean oil ... | 2007 | 16909228 |
| inhibitory effects of plant extracts on tyrosinase, l-dopa oxidation, and melanin synthesis. | for medical, pharmacological, and cosmetic reasons, the demand for effective and safe depigmentating agents has increased. in this study, 101 plant extracts (methanol or water extracts) were screened for their inhibitory activities against tyrosinase, (l-3, 4,-dihydroxyphenylalanine) l-dopa oxidation, and melanin biosynthesis in b16 mouse melanoma cells. of the extracts examined, 31 showed over 50% inhibition of mushroom tyrosinase at a concentration of 666 microg/ml, and 11 inhibited l-dopa aut ... | 2007 | 17454565 |
| protective effect of aqueous extract of perilla frutescens on tert-butyl hydroperoxide-induced oxidative hepatotoxicity in rats. | the leaves of perilla [perilla frutescens (l.) britt. var. japonica (hassk.) hara] are often used in asian gourmet food. the object of this study was to evaluate the protective effects of an aqueous extract of perilla leaves on the tert-butyl hydroperoxide (t-bhp)-induced oxidative injury observed in rat livers. the treatment of the hepatocytes with the perilla leaf extract (ple) significantly reversed the t-bhp-induced cell cytotoxicity and lipid peroxidation. in addition, ple exhibited ferric- ... | 2007 | 17467864 |
| increased carotenoid production in xanthophyllomyces dendrorhous g276 using plant extracts. | the red yeast xanthophyllomyces dendrorhous (previously named phaffia rhodozyma) produces astaxanthin pigment among many carotenoids. the mutant x. dendrorhous g276 was isolated by chemical mutagenesis. the mutant produced about 2.0 mg of carotenoid per g of yeast cell dry weight and 8.0 mg/l of carotenoid after 5 days batch culture with ym media; in comparison, the parent strain produced 0.66 mg/g of yeast cell dry weight and a carotenoid concentration of 4.5 mg/l. we characterized the utilizat ... | 2007 | 17483797 |
| growth inhibitory and apoptosis inducing effect of perilla frutescens extract on human hepatoma hepg2 cells. | perilla frutescens (l.) britt. (lamiaceae) has traditionally been used to treat diseases, including tumors, but the antitumorigenesis mechanism is unclear. we evaluated the effects of perilla frutescens leaf extract (ple) on proliferation and apoptosis inducing in human hepatoma hepg2 cells using a cell proliferation assay, flow cytometry, and cdna microarrays. gene expression and apoptosis were also assessed in hepg2 cells treated with a major constituent of ple, rosmarinic acid (rosa). in the ... | 2007 | 17574356 |
| polypeptide substrate specificity of pslsmt. a set domain protein methyltransferase. | rubisco large subunit methyltransferase (pslsmt) is a set domain protein responsible for the trimethylation of lys-14 in the large subunit of rubisco. the polypeptide substrate specificity determinants for pea rubisco large subunit methyltransferase were investigated using a fusion protein construct between the first 23 amino acids from the large subunit of rubisco and human carbonic anhydrase ii. a total of 40 conservative and non-conservative amino acid substitutions flanking the target lys-14 ... | 2007 | 17635932 |
| the interaction domains of the plant myc-like bhlh transcription factors can regulate the transactivation strength. | the n-terminal region of the plant myc-like basic helix-loop-helix transcription factors (bhlh tfs) contains two domains. approximately, 190 amino acids at the n-terminus comprise an interaction domain, a.k.a. myb-interacting-region (mir) for its primary function of interacting with myb-like tfs. following, the interaction domain is an activation (or acidic) domain responsible for transactivation. we have previously discovered that a lysine to methionine substitution (k157m) in the interaction d ... | 2008 | 18075757 |
| beta-secretase (bace1) inhibitors from perilla frutescens var. acuta. | in the course of screening for anti-dementia agents from natural products, two beta-secretase (bace1) inhibitors were isolated from the methanolic extract of perilla frutescens var. acuta and identified as luteolin (1) and rosmarinic acid (2) with ic50 values of 5.0 x 10(-7) m and 2.1 x 10(-5) m, respectively. they inhibited bace1 in a non-competitive manner with a substrate in dixon plots, suggesting that they might bind to either beta-secretase subsite or to another regulatory site. kivalues o ... | 2008 | 18365688 |
| differential gene expression profiles of red and green forms of perilla frutescens leading to comprehensive identification of anthocyanin biosynthetic genes. | differential screening by pcr-select subtraction was carried out for cdnas from leaves of red and green perilla, two chemovarietal forms of perilla frutescens regarding anthocyanin accumulation. one hundred and twenty cdna fragments were selected as the clones preferentially expressed in anthocyanin-accumulating red perilla over the nonaccumulating green perilla. about half of them were the cdnas encoding the proteins related presumably to phenylpropanoid-derived metabolism. the cdnas encoding g ... | 2008 | 18513325 |
| rosmarinic acid from perillae herba produces an antidepressant-like effect in mice through cell proliferation in the hippocampus. | rosmarinic acid (ra) is one of major polyphenolic ingredients of perillae herba (a leaf of perilla frutescens), and has an antidepressant-like property in animal models of depression. however, the mechanism(s) underlying this activity are unknown. recent studies have reported that regulation of hippocampal neurogenesis is associated with the pathogenesis of depression. to elucidate the mode of action of ra-induced antidepressant-like activity, proliferative effect of ra on newborn cells in the d ... | 2008 | 18591778 |
| antidepressant-like effect of l-perillaldehyde in stress-induced depression-like model mice through regulation of the olfactory nervous system. | perillae herba (a leaf of perilla frutescens) has been prescribed as one of the component herbs in certain kampo (japanese herbal) medicines that are used clinically for the improvement of depressive mood. l-perillaldehyde (pah) is a major component in the essential oil containing in perillae herba, but its antidepressant-like effect has not been reported. to clarify the antidepressant-like effect of pah, the inhaled effect of pah on stress-induced depression-like model mice prepared by subjecti ... | 2008 | 18955354 |
| effect of perilla frutescens aqueous extract on free radical production by human neutrophil leukocytes. | the present study was intended to evaluate the antioxidant properties of aqueous extract of the perilla frutescens (l.) britton. | 2008 | 18971608 |
| [effect of organic amendments on soil fungi community and continuous cropping panax quinquefolium]. | to study the effect of different organic amendments treated replant soil and to find the relations between the soil fungi community and the growth of panax quinquefolium l. seedling. | 2008 | 18973004 |
| fragrant unsaturated aldehydes elicit activation of the keap1/nrf2 system leading to the upregulation of thioredoxin expression and protection against oxidative stress. | thioredoxin, a key molecule in redox regulation, and many redox enzymes are regulated through the antioxidant responsive element (are). to search for antioxidative constituents, we screened extracts from vegetables and found that the extracts of perilla frutescens and artemisia princeps have potent thioredoxin-inducing activities. by activity-guided purification of perilla frutescens extracts, we identified perillaldehyde as a novel thioredoxin inducer. fragrant unsaturated aldehydes, such as tr ... | 2009 | 19123792 |
| rosmarinic acid inhibits 6-ohda-induced neurotoxicity by anti-oxidation in mes23.5 cells. | rosmarinic acid (ra) is a naturally occurring polyphenolic compound. it is found in several herbs in the lamiaceae family, such as perilla frutescens. ra has been reported to exert anti-oxidative effects on rat erythrocyte, liver, and kidney cells. however, little is known about the effects of ra on dopaminergic cells. in the present study, we investigated whether ra could protect mes23.5 dopaminergic cells from 6-hydroxydopamine (6-ohda)-induced neurotoxicity. the results showed that ra pretrea ... | 2009 | 19219567 |
| perilla leaf, perilla frutescens, induces apoptosis and g1 phase arrest in human leukemia hl-60 cells through the combinations of death receptor-mediated, mitochondrial, and endoplasmic reticulum stress-induced pathways. | since it has been reported that perilla leaves (perilla frutescens) have antimutagenic, antioxidant, and anti-inflammatory properties, we hypothesized that perilla leaves may have a potential anticancer activity. therefore, we examined the possibility that cancer cell growth is reduced by treatment with a perilla leaf ethanol extract (ple) using human leukemia hl-60 cells and then investigated the mechanism of the growth inhibition. we found that ple treatment suppressed cell viability in a dose ... | 2009 | 19627198 |
| herbal formula syjn protect pc12 cells from neurotoxicity induced by corticosterone. | syjn is a chinese herbal formula, containing four herbs: bupleurum chinense dc., curcuma aromatica salisb., perilla frutescens (linn.) britt. and acorus tatarinowii schott. previous studies on the formula in our laboratory revealed an antidepressant-like effect on animal models of behavioral despair. however,the mechanisms underlying such antidepressant-like effect are yet to be understood. the aim of this work was to verify the previously established antidepressant-like effects on cell level us ... | 2009 | 19635548 |
| functional activation of monoamine transporters by luteolin and apigenin isolated from the fruit of perilla frutescens (l.) britt. | monoamine transporters playing major roles in regulating normal and abnormal synaptic activity are associated with various neuropsychological disorders. in spite of the discovery of a series of structurally different monoamine transporter antagonists for the therapy approach, no practical pharmaceutical can act as a transporter activator. here, we isolated luteolin and apigenin from the fruit of perilla frutescens (l.) britt by using an activity-guided extraction technique, and proved that the t ... | 2010 | 19815045 |
| effect of spinacia oleraceae l. and perilla frutescens l. on antioxidants and lipid peroxidation in an intervention study in healthy individuals. | daily consumption of fruits and vegetables is frequently recommended to prevent several diseases. this health-promoting effect is considered to be in part due to the antioxidant content of fruits and vegetables and their ability to decrease oxidative stress. to investigate whether the ingestion of preparations from spinach or perilla, two carotenoid-rich leafy vegetables, is followed by an increase in carotenoid concentration and/or affects parameters of oxidative stress in human blood plasma. 1 ... | 2010 | 20052549 |
| a candidate cdna clone for (-)-limonene-7-hydroxylase from perilla frutescens. | cytochrome p450 mono-oxygenases from peppermint, spearmint and perilla (all members of the family lamiaceae) mediate the regiospecific hydroxylation of the parent olefin (-)-limonene to produce essential oil components oxygenated at c3, c6 and c7, respectively. cloning, expression and mutagenesis of cdnas encoding the peppermint limonene-3-hydroxylase and the spearmint limonene-6-hydroxylase have allowed the identification of a single amino acid residue which determines the regiospecificity of o ... | 2010 | 20079506 |
| plant derived omega-3-fatty acids protect mitochondrial function in the brain. | perilla frutescens seed oil (pfso) represents a rich source of unsaturated fatty acids, especially of omega-3 linolenic acid and is commonly used as herbal food supplement with beneficial effects on the vascular system. the present study investigated the effects of pfso on the central nervous system (cns) and provides new insight into potential mechanisms for protective properties of unsaturated fatty acids within the cns. pfso was administered chronically to guinea pigs and neuroprotective prop ... | 2010 | 20079842 |
| effects of syjn, a chinese herbal formula, on chronic unpredictable stress-induced changes in behavior and brain bdnf in rats. | suyu-jiaonang (syjn) is a chinese herbal formula that contains four herbs: bupleurum chinense dc, curcuma aromatica salisb., perilla frutescens (linn.) britt., and acorus tatarinowii schott. previous studies conducted in our laboratory have revealed an antidepressant-like effect of the formula in various mouse models of behavioral despair. the present study aimed to investigate whether syjn could produce antidepressant-like effects in chronic unpredictable stress (cus)-induced depression model i ... | 2010 | 20138132 |
| the role of beta-ketoacyl-acyl carrier protein synthase iii in the condensation steps of fatty acid biosynthesis in sunflower. | the beta-ketoacyl-acyl carrier protein synthase iii (kas iii; ec 2.3.1.180) is a condensing enzyme catalyzing the initial step of fatty acid biosynthesis using acetyl-coa as primer. to determine the mechanisms involved in the biosynthesis of fatty acids in sunflower (helianthus annuus l.) developing seeds, a cdna coding for hakas iii (ef514400) was isolated, cloned and sequenced. its protein sequence is as much as 72% identical to other kas iii-like ones such as those from perilla frutescens, ja ... | 2010 | 20221630 |
| luteolin from purple perilla mitigates ros insult particularly in primary neurons. | increased attention has been paid to the role of oxidant/antioxidant imbalance in neurodegenerative process and pharmaceutical neuroprotective interventions. food-derived compound luteolin possesses multitarget actions including reactive oxygen species (ros)-scavenging activity in cultured human endothelial cells or permanent immature rat oligodendrocytes. this study aims to elucidate whether luteolin has a neuroprotective tendency toward ros-insulted neural cells. the present results showed tha ... | 2010 | 20382451 |
| herbal formula syjn increases neurotrophin-3 and nerve growth factor expression in brain regions of rats exposed to chronic unpredictable stress. | syjn is a chinese herbal formula that contains four herbs: bupleurum chinense dc., curcuma aromatica salisb., perilla frutescens (l.) britt., and acorus tatarinowii schott. previous studies conducted in our laboratory have revealed an antidepressant-like effect of the formula in chronic unpredictable stress (cus)-induced depression model in rats. the present study aimed to investigate whether neurotrophin-3 (nt-3) and nerve growth factor (ngf) are involved in the antidepressant-like action of sy ... | 2010 | 20600769 |
| isolation of basidiomycetous yeast pseudozyma tsukubaensis and production of glycolipid biosurfactant, a diastereomer type of mannosylerythritol lipid-b. | the producers of glycolipid biosurfactant, mannosylerythritol lipid-b (mel-b), were isolated from leaves of perilla frutescens on ibaraki in japan. four isolates, 1d9, 1d10, 1d11, and 1e5, were identified as basidiomycetous yeast pseudozyma tsukubaensis by rdna sequence and biochemical properties. the structure of mel-b produced by these strains was analyzed by (1)h nuclear magnetic resonance and gas chromatography-mass spectrometry methods, and was determined to be the same as the diastereomer ... | 2010 | 20652239 |
| apigenin isolated from the seeds of perilla frutescens britton var crispa (benth.) inhibits food intake in c57bl/6j mice. | energy balance is monitored by the hypothalamus, which responds to peripheral signals by releasing neuropeptides that regulate energy intake and expenditure. in this study, we constructed pro-opiomelanocortin (pomc) and "cocaine and amphetamine-related transcript" (cart) promoter-driven luciferase plasmids and transformed them permanently into both n29-2 neuronal cells and human shsy5y cells. using reporter gene assays, we identified apigenin from the seeds of perilla frutescens britton var cris ... | 2010 | 21116776 |
| [effect of zinc sulphate and peg priming on ageing seed germination and antioxidase activities of perilla frutescens seedlings]. | to explore the method for improving the aging resistance of seeds and seedlings of perilla frutescens through study on seed germination and physiological characteristics of p. frutescens seedlings. | 2010 | 21141480 |
| optimization of antibacterial activity of perilla frutescens var. acuta leaf against pseudomonas aeruginosa using the evolutionary operation-factorial design technique. | this study was undertaken to optimize the conditions for the extraction of antibacterial activity of perilla frutescens var. acuta leaf against pseudomonas aeruginosa kctc 2004 using the evolutionary operation-factorial (evop) design technique. increased antibacterial activity was achieved at higher extraction temperatures and with a longer extraction time. antibacterial activity was not affected by differing ethanol concentration in the extraction solvent. the maximum antibacterial activity of ... | 2010 | 21152309 |
| perilla frutescens seed agar, a new medium for identification of the cryptococcus species complex: evaluation for all major molecular types. | here we present a new and simple medium made by perilla frutescens seed as a tool for identification of the cryptococcus species complex, namely cryptococcus neoformans and cryptococcus gattii. its usefulness was evaluated for all major molecular types within the cryptococcus species complex. as a result, this medium is better for identification of the species complex compared with guizotia abyssinica or helianthus annuus seed medium. | 2010 | 21182875 |
| postischemic administration of liposome-encapsulated luteolin prevents against ischemia-reperfusion injury in a rat middle cerebral artery occlusion model. | oxidative stress-induced neuronal cell death has been implicated in neurodegenerative diseases; one such disease is ischemic stroke. using reactive oxygen species (ros)-insulted primary neurons, we screened neuroprotectants with clinical potential and then, using ischemia/reperfusion (i/r) model, investigated the anti-ischemic potential of candidate neuroprotectants. here, we showed that luteolin, isolated from the ripe fruit of perilla frutescens (l.) britt, exhibited a neuroprotective action u ... | 2010 | 21190830 |
| effect of perilla frutescens var. acuta kudo and rosmarinic acid on allergic inflammatory reactions. | allergy is characterized by an overreaction of the immune system. perilla frutescens leaf extract has been reported to exhibit antiallergic inflammatory activity. to investigate precisely the effect and mechanism of 30% ethanol extract powder of p. frutescens var. acuta kudo (eppf) and rosmarinic acid (ra), a component of eppf in allergic rhinitis and rhinoconjunctivitis, the antiallergic effects of eppf and ra were analyzed using in vivo and in vitro models. cytokine production was analyzed by ... | 2011 | 21239739 |
| subinhibitory concentrations of perilla oil affect the expression of secreted virulence factor genes in staphylococcus aureus. | the pathogenicity of staphylococcus aureus is dependent largely upon its ability to secrete a number of virulence factors, therefore, anti-virulence strategy to combat s. aureus-mediated infections is now gaining great interest. it is widely recognized that some plant essential oils could affect the production of staphylococcal exotoxins when used at subinhibitory concentrations. perilla [perilla frutescens (l.) britton], a natural medicine found in eastern asia, is primarily used as both a medi ... | 2011 | 21283822 |
| [effect of exogenous ca2+ and no donor snp on seed germination and antioxidase activities of perilla frutescens seedlings under nacl stress]. | in order to find a method for improving the salt resistance of seeds and seedlings for perilla frutescens under nacl stress, seed germination and physiological characteristics of p. frutescens seedlings were studied. | 2010 | 21355229 |
| [effect of exogenous ca2+, ala, sa and spd on seed germination and physiological characteristics of perilla frutescens seedlings under nacl stress]. | to find a method for improving the salt resistance of seeds and seedlings for perilla frutescens under nacl stress, seed germination and physiological characteristics of p. frutescens seedlings were studied. | 2010 | 21438385 |
| alleviation of atopic dermatitis-related symptoms by perilla frutescens britton. | to ascertain whether an aqueous fraction of perilla frutescens britton (pfb/af) has advantageous anti-atopic dermatitis activity, we used a 2,4-dinitrofluorobenzene (dnfb)-induced animal model of atopic dermatitis symptoms to investigate the effects of the extract. we performed an ear swelling assay by comparing thickness of the dnfb-induced ear, and measured the numbers of eosinophils as well as total immune cells. we analyzed the expression levels of matrix metalloproteinase (mmp)-9, interleuk ... | 2011 | 21811759 |
| dietary perilla seed oil supplement increases plasma omega-3 polyunsaturated fatty acids and ameliorates immunoglobulin a nephropathy in high immunoglobulin a strain of ddy mice. | background/aims: the beneficial effects of omega-3 polyunsaturated fatty acids (n-3 pufa) in the treatment of immunoglobulin a nephropathy (igan) have been reported. perilla frutescens (linn.) britton var. frutescens is grown in eastern asia and its seed (perilla seed) is rich in +¦-linolenic acid, an n-3 pufa. we investigated the antinephritic effects of perilla seed oil in a mouse model of igan. methods: ten-week-old high iga ddy mice were fed diets containing either perilla seed oil (ps group ... | 2011 | 21734409 |
| isoegomaketone induces apoptosis through caspase-dependent and caspase-independent pathways in human dld1 cells. | isoegomaketone (ik) is an essential oil component of perilla frutescens (l.), but the mechanism by which ik induces apoptosis has never been studied. the purpose of this study was to elucidate the ik-induced apoptotic pathway in dld1 human colon cancer cells. we observed that ik treatment over 24 h significantly inhibited cell viability in a dose-dependent manner. we also found that ik triggered cleavage of parp. moreover, ik treatment resulted in cleavage of caspase-8, -9, and -3 in a dose- and ... | 2011 | 21737934 |
| optimization of antibacterial activity of perilla frutescens var. acuta leaf against staphylococcus aureus using evolutionary operation factorial design technique. | this study was undertaken to optimize extraction using evolutionary operation-factorial (evop) design technique to elicit the antibacterial activity of perilla frutescens var. acuta leaf against staphylococcus aureus atcc6538. higher antibacterial activity was achieved at higher extraction temperature and over a longer extraction time. antibacterial activity was not affected by differentiation of the ethanol concentration in the extraction solvent. the maximum antibacterial activity of ethanolic ... | 2011 | 21731448 |
| Perilla frutescens: interesting new medicinal and melliferous plant in Italy. | The goal of this study is to inform those potentially interested (researchers, farmers, industry and public bodies) in the medicinal and aromatic properties, and profitability of Perilla frutescens (L.) Britton (Lamiaceae). Perilla, a medicinal and edible plant of Asian origin, was recently introduced to the Piedmont Region in the north-west of Italy. P. frutescens is commonly known for its anti-allergic, anti-tumor, and anti-oxidant properties. It is also widely used as human food. We collected ... | 2011 | 22164783 |
| [effect of exogenous nitric oxide donor snp on seed germination and antioxidase activities of perilla frutescens seedlings under nacl stress]. | to explore the method of improving the salt resistance ability of seeds and seedlings of perilla frutescens under nacl stress. | 2011 | 21954550 |
| biological evaluation of isoegomaketone isolated from perilla frutescens and its synthetic derivatives as anti-inflammatory agents. | the anti-inflammatory activities of a prepared isoegomaketone 3a and its derivatives 3b-3f were evaluated in raw 264.7 cells. among these, the compound 3d was displayed the most potent inhibitory activities against production of nitric oxide, monocyte chemoattractant protein-1 and interleukin-6. based on these results, the abilities of compounds 3a-3f to modulate nf-κb and ap-1-mediated gene transcription using a luciferase reporter assay were investigated. the transcriptional activities of nf-κ ... | 2011 | 21910048 |
| health effects of omega-3,6,9 fatty acids: perilla frutescens is a good example of plant oils. | perilla frutescens seeds are a good source of polyunsaturated fatty acids (pufas). the seeds of perilla are small end globular weight about 4 g/1000, contained approximately 35-45% oil. however the leaves are a very poor source of oil, since they contain only 0.2%. in addition, only the seed oil contains the omega 3 fatty acid alpha-linolenic acid (ala). in comparing to other plant oils, perilla seed oil consistently contains the one of the highest proportion of omega-3 (ala) fatty acids, at 54- ... | 2011 | 21909287 |
| [comparative analysis of volatile components of medicinal materials from perilla frutescens]. | to analyze the differences of volatile components of medicinal materials from perilla frutescens (perillae folium; perillae caulis; perillae fructus). | 2012 | 23705362 |
| natural products: perspectives in the pharmacological treatment of gastrointestinal anisakiasis. | to evaluate the activity of different natural products against l3 larvae of anisakis type i. | 2015 | 26321513 |
| calcium and oxidative stress mediate perillaldehyde-induced apoptosis in candida albicans. | new anti-candida albicans drugs are needed due to the emergence of resistant cases in recent years. perillaldehyde (pae) is a natural monoterpenoid compound derived from perilla frutescens. the minimum inhibitory concentration of pae against c. albicans was 0.4 μl/ml. we aimed to elucidate the antifungal mode of action of pae against c. albicans. the antifungal activity of pae against c. albicans was found to correlate with an elevation in intracellular ca(2+) and accumulation of ros. several do ... | 2017 | 28224196 |
| authentic seed-specific activity of the perilla oleosin 19 gene promoter in transgenic arabidopsis. | the perilla (perilla frutescens l. cv. okdong) oleosin gene, pfole19, produces a 19-kda protein that is highly expressed only in seeds. the activity of the -2,015 bp 5'-upstream promoter region of this gene was investigated in transgenic arabidopsis plants using the fusion reporter constructs of enhanced green fluorescent protein (egfp) and beta-glucuronidase (gus). the pfole19 promoter directs egfp expression in developing siliques, but not in leaves, stems or roots. in the transgenic arabidops ... | 2008 | 17891401 |