| study of structure--hepatoprotective relationships of oleanene-type triterpenoidal glucuronides obtained from several fabaceous plants on rat primary hepatocyte cultures. | the protective effects of nine oleanene-type triterpenoidal glucuronides obtained from several fabaceous plants (lupinus polyphyllus x arboreus hybrid, astragalus complanatus, wistaria brachybotrys) on in vitro immunological liver injury in primary cultured rat hepatocytes were studied. although all tested saponins showed hepatoprotective action, the levels of activity of the individual saponins differed. structure-activity relationships for the sapogenol moiety suggested that the presence of th ... | 1999 | 10077443 |
| antihypertensive effect of total flavonoid fraction of astragalus complanatus in hypertensive rats. | the purpose of the present study was to quantify the antihypertensive effect of the total flavonoid (tf), extracted from the seed of astragalus complanatus r. brown, and to observe its effect on the renin-angiotensin system (ras) in both renal hypertensive rats (rhr) and spontaneously hypertensive rats (shr). rhr were created by the two-kidney one clip (2k1c) method. systolic blood pressure was measured in conscious rats by the tail-cuff method. plasma angiotensin ii (angii) and plasma renin act ... | 2005 | 16201455 |
| effect of astragalus complanatus flavonoid on anti-liver fibrosis in rats. | to observe the anti-liver fibrosis effect of astragalus complanatus flavonoids (acf) in rats. | 2005 | 16270385 |
| effect of total flavonoid fraction of astragalus complanatus r. brown on angiotensin ii-induced portal-vein contraction in hypertensive rats. | the objective of the present study was to examine further the underlying mechanism of the antihypertensive effect of the total flavonoid (tf), extracted from the seed of astragalus complanatus r.brown. renovascular hypertension rats (rhr) were established by the two-kidney one clip (2k1c) method. the effect of tf on the contraction of portal vein was studied in an isolated preparation. the response of portal vein to angiotensin ii (ang ii) was expressed as a percentage of the 100 mmol/l kcl indu ... | 2008 | 18406589 |
| induction of apoptosis in human hepatocarcinoma smmc-7721 cells in vitro by flavonoids from astragalus complanatus. | flavonoids extracted from the seeds of astragalus complanatus r.br. reduce the proliferation of many cancer cells. the present study was carried out to evaluate the effects of these flavonoids from astragalus complanatus (fac) on human hepatocarcinoma cell viability and apoptosis and to investigate its mechanisms of action in smmc-7721 cells. | 2009 | 19429375 |
| protective effect of flavonoids from astragalus complanatus on radiation induced damages in mice. | this study aimed to evaluate the radioprotective effect of flavonoids extracted from the seeds of astragalus complanatus r.br. (fac) and their protective mechanism against radiation damage. fac increased the survival rate of mice and made the damaged organ injured by (60)co γ-irradiation recovered to normal appearance with the mechanism of enhancing immune function and blood-producing function in vivo. the molecule mechanism of fac against radiation is involved in the reduction of dna injury and ... | 2010 | 21075176 |
| [study on microscopic identification of astragalus complanatus and a. adsurgens seeds]. | astragalus adsurgens seed is one of the most common adulterants of astragali complanati semen in the market, whose morphological characteristics are very similar with a. complanatus seeds (astragali complanati semen). many identification methods have been reported, such as morphological identification, fluorescence method, ultraviolet spectrophotometry, tlc, hplc, protein electrophoresis and so on, but there's no much about microscopic identification. in the present study, the morphological char ... | 2015 | 26281544 |
| its2 barcoding dna region combined with high resolution melting (hrm) analysis of hyoscyami semen, the mature seed of hyoscyamus niger. | hyoscyami semen, the mature dried seed of hyoscyamus niger l., has long been used as a traditional chinese medicine to treat human diseases. hyoscyami semen is found in local markets in china. in markets, sellers and buyers commonly inadvertently mix the seeds of h. niger with the seeds of related species such as hygrophila salicifolia (vahl) nees, astragalus complanatus r. br., cuscuta australis r. br., cuscuta chinensis lam., and impatiens balsamina l. because of their similar morphologies or ... | 2016 | 28262116 |
| simultaneous determination of formononetin, calycosin and rhamnocitrin from astragalus complanatus by uhplc-ms-ms in rat plasma: application to a pharmacokinetic study. | this assay provided a novel and generally applicable method to simultaneously determine formononetin, calycosin and rhamnocitrin in rat plasma based on ultra-high performance liquid chromatography with tandem mass spectrometry. a single step of protein precipitation procedure with methanol was utilized, and luteolin was chosen as an internal standard. chromatographic separation was achieved using a waters symmetry-c18 column, and the applied isocratic elution program allowed for the simultaneous ... | 2016 | 27325683 |
| [effect of total flavonoids from astragalus complanatus on paraquat poisoning-induced pulmonary fibrosis in rats and its mechanisms]. | to investigate the effects of total flavonoids from astragalus complanatus (fac) on paraquat poisoning-induced pulmonary fibrosis in rats. | 2015 | 26887268 |
| quantification of complanatoside a in rat plasma using lc-ms/ms and its application to a pharmacokinetic study. | complanatoside a is a flavonol glycoside isolated from astragalus complanatus, and currently it is used as a quality control index for a. complanatus in the 2010 edition of the chinese pharmacopoeia. for the first time, a simple and sensitive lc-ms/ms method was developed for the determination of complanatoside a in rat plasma over the range of 2.3-575 ng/ml. complanatoside a was extracted from plasma by a protein precipitation procedure, separated by lc and detected by ms/ms in positive electro ... | 2016 | 26393341 |
| effect of total flavonoids from the seeds of astragali complanati on natural killer cell function. | the seeds of astragalus complanatus r.br. (ac), a traditional chinese medicine, have been extensively used for clinical treatment of liver and kidney complaints and tumors for more than a thousand years. it was believed that ac is warm and sweet in the most authoritative medical book of ancient china "compendium of materia medica". our previous studies showed that the flavonoid component from the seeds of astragalus complanatus (fac) is mainly an active constituent and has the hepatoprotective e ... | 2015 | 26196400 |
| effects and mechanism of flavonoids from astragalus complanatus on breast cancer growth. | flavonoids from astragalus complanatus r.br (fac) had anticancer effects on many tumor cells. the current study was performed to evaluate the effects of fac on human breast cell proliferation, apoptosis, and metastasis, as well as their active mechanism. cell viability and growth were detected using the cell counting kit (cck)-8 assay in vitro. assay of fac on induced breast cancer mortality was counted as survival time of nude mice after breast cell line inoculation. the effect of fac on cell i ... | 2015 | 25902740 |
| semen astragali complanati: an ethnopharmacological, phytochemical and pharmacological review. | semen astragali complanati (sac), the dried ripe seed of flatstem milkvetch (astragalus complanatus bunge) (leguminosae), is commonly used in traditional chinese medicine (tcm) for treating muscle, liver, kidney, blood, skin and reproductive system diseases. | 2014 | 24933224 |
| [total flavonoids from astragalus complanatus attenuates lung injury following paraquat poisoning in rats through inhibiting excessive endoplasmic reticulum stress and c-jun n-terminal kinase pathway]. | to investigate the effect of total flavonoids from astragalus complanatus (fac) on attenuating lung injury resulted from paraquat (pq) poisoning by inhibiting excessive endoplasmic reticulum stress (ers) and c-jun n-terminal kinase (jnk) pathway in rat. | 2014 | 24912635 |
| extraction, antioxidant capacity and identification of semen astragali complanati (astragalus complanatus r. br.) phenolics. | a study about the ultrasonic extraction, antioxidant capacity and identification of phenolics from semen astragali complanati was undertaken. the optimised extraction condition with an orthogonal experiment design of l9(3(4)) was 50°c, 30min and 15:1 (methanol solution:sample, ml:g). an extraction yield of 40.12±1.10mg gallic acid/g dry seed and the antioxidant capacity of 0.85±0.13mg dry extract/mg dpph were obtained with the optimum condition, respectively. for each extraction set, the antioxi ... | 2013 | 23790916 |
| preliminary study of protective effects of flavonoids against radiation-induced lung injury in mice. | radiation therapy plays an important role in lung carcinoma treatment. however, the incidence of symptomatic radiation-induced lung injury is high. this study aimed to evaluate radioprotective effects of flavonoids extracted from astragalus complanatus and mechanisms of action against radiation damage. | 2012 | 23464472 |
| [determination of complanatoside a in semen astragali complanati by hplc]. | to establish the determination method for complanatoside a in seeds of astragalus complanatus. | 2005 | 16011285 |
| [identification on genuine and pseudo shayuanzi collected from different place by hplc fingerprint]. | to establish the identification method for genuine and pseudo shayuanzi by hplc fingerprint. | 2003 | 15015372 |
| [identification and evaluation of tcm shayuanzi]. | to understand the varieties of shayuanzi on sale and establish the method for evaluating its quality. | 2003 | 15015323 |
| [karyotype analysis of astragalus complanatus chromosome]. | micrograph were used to analyse the number, karyotype and volume of chromosome of astragalus complanatus. the normal diploid 2n = 16, karyotype formula based on levean publication (1964) was k(2n) = 16 = 10 m + 6 sm. according to the method of s.r. guo, the chromosome relative length was 2n = 16 = 6m2 + 10m1, which belonged to "2a" type according to the stebbins' karyotype classification. the total length of chromosome groups was 33.05 microns, total length of long arms was 19.76 microns, from a ... | 2002 | 12599690 |
| [studies on the efficacious constituents of astragalus complanatus]. | the petroleum ether extract of astragalus complanatus r. br. showed activity for lowering the transaminase levels in mice. from this extract six compounds were isolated. among them five were identified as rhamnocitrin (i), formononetin (ii), stigmasterol (iv), phosphatidylethanolamine (v) and phosphatidylinositol (vi). the other one was shown to be a new p-coumaroyl derivative, 11-o-p-coumarylnepeticin. their structures were elucidated by spectrometric and chemical analyses. all the six compound ... | 1997 | 11243221 |
| [chemical constituents of the seed oil of astragalus complanatus r. brown]. | beta-sitosterol and fatty acids were obtained from the oil of seeds of astragalus complanatus. the fatty acids were separated and their molecular weights determined by gc-ms. fourteen of them were identified as heptenoic acid, tetradecanoic acid, pentadecanoic acid, hexadecanoic acid, octadecenoic acid, octadecanoic acid, octadecadienoic acid, linolenic acid, eicosanoic acid, eicosenoic acid and docosanoic acid, etc. | 1990 | 2206374 |
| [morphology of the seeds of astragalus complanatus r.br. and astragalus on the scanning electron microscope]. | we have observed the seeds of astragalus complanatus and its 18 species and divided them into three groups by comparing their shapes, sizes and morphology of seed cuticles with scanning electron microscope. | 1989 | 2506891 |
| [studies on chemical constituents of astragalus complanatus r. br]. | sha-yuan-zi is the seeds of astragalus complanatus r. br.. eight compounds were isolated from its 80% ethanolic extract. their structures have been identified by spectroscopic and chemical methods. two of them are new and named neocomplanoside (vii) and myricomplanoside-(viii) respectively. all the compounds were obtained from sha-yuan-zi for the first time. | 1989 | 2816374 |
| [studies on chemical constituents of astragalus complanatus r. brown. ii]. | | 1988 | 3421111 |
| [chemical constituents of astragalus complanatus. i. separation and analysis of amino acids]. | | 1987 | 2955940 |