| isolation and characterization of whitewater arroyo virus, a novel north american arenavirus. | rodents are principal hosts for each of the well-characterized arenaviruses. prior to the present study, tamiami (tam) virus was the sole arenavirus known to be indigenous to north america; it has been isolated only from southern florida where its primary host is the cotton rat sigmodon hispidus. recently, arenavirus antibody was found in neotoma albigula woodrats collected from the southwestern united states. the purpose of the present study was to isolate and characterize the arenavirus associ ... | 1996 | 8862405 |
| the whitewater arroyo virus: natural evidence for genetic recombination among tacaribe serocomplex viruses (family arenaviridae). | the tacaribe serocomplex (family arenaviridae) comprises three phylogenetic lineages, designated a, b, and c. the sequence of a 3278-nt fragment of the small genomic segment of the whitewater arroyo (wwa) virus was determined to extend our knowledge on the phylogenetic relationship of this newly discovered north american tacaribe complex virus to other arenaviruses. independent analyses of full-length nucleoprotein (n) and glycoprotein precursor (gpc) amino acid sequences indicated that the wwa ... | 2001 | 11336541 |
| transmission of an arenavirus in white-throated woodrats (neotoma albigula), southeastern colorado, 1995-1999. | from 1995 to 1999, we conducted longitudinal studies of white- throated woodrats (neotoma albigula) in southeastern colorado. forty-five (42.9%) of 105 female and 15 (26.8%) of 56 male n. albigula had antibodies against whitewater arroyo virus (wwav). sixteen female and three male n. albigula seroconverted during the study period, most of them during july-november, when population densities are highest. analyses of longevity data, minimum numbers alive and infected, movements, and weight data su ... | 2001 | 11384515 |
| geographic distribution and genetic diversity of whitewater arroyo virus in the southwestern united states. | the purpose of this study was to extend our knowledge of the geographic distribution and genetic diversity of the arenavirus(es) associated with neotoma species (woodrats) in the southwestern united states. infectious arenavirus was recovered from 14 (3.3%) of 425 woodrats. the virus-positive species included n. albigula in new mexico and oklahoma, n. cinerea in utah, n. mexicana in new mexico and utah, and n. micropus in texas. analyses of viral nucleocapsid protein gene sequence data indicated ... | 2001 | 11384516 |
| experimental infection of neotoma albigula (muridae) with whitewater arroyo virus (arenaviridae). | the whitewater arroyo virus (wwa) is a newly described north american arenavirus. the purpose of this study was to elucidate the biology of this virus in its natural rodent host, neotoma albigula (white-throated woodrat). thirteen adult, 7 juvenile, and 8 newborn woodrats each were inoculated subcutaneously with 1,000 cell culture infectious dose50 of the wwa virus prototype strain av 9310135. all 28 animals became infected (as measured by the recovery of infectious virus and/or seroconversion) ... | 2001 | 11508391 |
| phylogeny of new world arenaviruses based on the complete coding sequences of the small genomic segment identified an evolutionary lineage produced by intrasegmental recombination. | previous studies suggested that the small genomic segments (s-rna) of the south american arenaviruses (sa-avs) represent three phylogenetic lineages (designated a, b, and c) and indicated that the s-rna of whitewater arroyo virus (wwav) (a north american arenavirus [na-av]) is a product of genetic recombination between a lineage a and lineage b virus. the purpose of this study was to extend our knowledge on the phylogenetic relationships between wwav, the two other na-avs (tamiami and bear canyo ... | 2002 | 12207889 |
| natural host relationships and genetic diversity of whitewater arroyo virus in southern texas. | the purpose of this study was to refine our knowledge of the natural host relationships of whitewater arroyo (wwa) virus. two hundred eight rodents, representing nine species, were captured in july 1999 on the chaparral wildlife management area in southern texas and tested for evidence of arenavirus infection. antibody to an arenavirus was found in seven (21.9%) of 32 southern plains woodrats (neotoma micropus) and none of 168 other rodents. infectious wwa virus was isolated from four antibody-p ... | 2002 | 12363054 |
| exposure to rodents and rodent-borne viruses among persons with elevated occupational risk. | persons who have frequent contact with rodents as part of their occupation may be at increased risk of exposure to rodent-borne viruses such as sin nombre virus (snv), the agent of hantavirus pulmonary syndrome, and whitewater arroyo virus (wwa), a new world arenavirus. eighty-one persons with possible occupational exposure to rodents completed questionnaires and provided specimens for serologic testing. seventy-two participants reported handling rodents as part of their job. the mean total numb ... | 2002 | 12391776 |
| hantavirus and arenavirus antibodies in persons with occupational rodent exposure. | rodents are the principal hosts of sin nombre virus, 4 other hantaviruses known to cause hantavirus pulmonary syndrome in north america, and the 3 north american arenaviruses. serum samples from 757 persons who had worked with rodents in north america and handled neotomine or sigmodontine rodents were tested for antibodies against sin nombre virus, whitewater arroyo virus, guanarito virus, and lymphocytic choriomeningitis virus. antibodies against sin nombre virus were found in 4 persons, agains ... | 2007 | 17553266 |
| catarina virus, an arenaviral species principally associated with neotoma micropus (southern plains woodrat) in texas. | the purpose of this study was to define the taxonomic relationship of an arenavirus principally associated with the southern plains woodrat (neotoma micropus) in southern texas to other new world arenaviruses. the results of independent analyses of glycoprotein precursor amino acid sequences and nucleocapsid protein amino acid sequences indicated that the arenavirus in southern texas is novel (proposed species name catarina virus) and phylogenetically most closely related to whitewater arroyo vi ... | 2007 | 17978080 |
| receptor use by the whitewater arroyo virus glycoprotein. | whitewater arroyo virus (wwav) is a north american new world arenavirus, first isolated from rats in new mexico in 1993, and tentatively associated with three human fatalities in california in 1999-2000. however, it remains unclear whether wwav was the cause of these, or any other, human infections. one important characteristic of viruses that influences pathogenic potential is the choice of cellular receptor and the corresponding tropism of the virus. in the arenaviruses, these properties are d ... | 2008 | 17997467 |
| diversity among tacaribe serocomplex viruses (family arenaviridae) naturally associated with the mexican woodrat (neotoma mexicana). | the results of analyses of glycoprotein precursor and nucleocapsid protein gene sequences indicated that an arenavirus isolated from a mexican woodrat (neotoma mexicana) captured in arizona is a strain of a novel species (proposed name skinner tank virus) and that arenaviruses isolated from mexican woodrats captured in colorado, new mexico, and utah are strains of whitewater arroyo virus or species phylogenetically closely related to whitewater arroyo virus. pairwise comparisons of glycoprotein ... | 2008 | 18304671 |
| diversity among tacaribe serocomplex viruses (family arenaviridae) naturally associated with the white-throated woodrat (neotoma albigula) in the southwestern united states. | bayesian analyses of glycoprotein precursor and nucleocapsid protein gene sequences indicated that arenaviruses naturally associated with white-throated woodrats in central arizona are phylogenetically closely related to the whitewater arroyo virus prototype strain av 9310135, which originally was isolated from a white-throated woodrat captured in northwestern new mexico. pairwise comparisons of glycoprotein precursor and nucleocapsid protein amino acid sequences revealed extensive diversity amo ... | 2008 | 18454597 |
| a multivalent vaccination strategy for the prevention of old world arenavirus infection in humans. | arenaviruses cause severe human disease ranging from aseptic meningitis following lymphocytic choriomeningitis virus (lcmv) infection to hemorrhagic fever syndromes following infection with guanarito virus (gtov), junin virus (junv), lassa virus (lasv), machupo virus (macv), sabia virus (sabv), or whitewater arroyo virus (wwav). cellular immunity, chiefly the cd8(+) t-cell response, plays a critical role in providing protective immunity following infection with the old world arenaviruses lasv an ... | 2010 | 20668086 |
| antibodies to tacaribe serocomplex viruses (family arenaviridae, genus arenavirus) in cricetid rodents from new mexico, texas, and mexico. | blood samples from 4893 cricetid rodents were tested for antibody (immunoglobulin g) to whitewater arroyo virus and amaparí virus to extend our knowledge of the natural host range and geographical distribution of tacaribe serocomplex viruses in north america. antibodies to arenaviruses were found in northern pygmy mice (baiomys taylori), woodrats (neotoma spp.), northern grasshopper mice (onychomys leucogaster), oryzomys (oryzomys spp.), deermice (megadontomys nelsoni and peromyscus spp.), harve ... | 2010 | 20795917 |
| novel arenavirus infection in humans, united states. | immunoglobulin g against whitewater arroyo virus or lymphocytic choriomeningitis virus was found in 41 (3.5%) of 1,185 persons in the united states who had acute central nervous system disease or undifferentiated febrile illnesses. the results of analyses of antibody titers in paired serum samples suggest that a north american tacaribe serocomplex virus was the causative agent of the illnesses in 2 persons and that lymphocytic choriomeningitis virus was the causative agent of the illnesses in 3 ... | 2011 | 21801618 |
| human and host species transferrin receptor 1 use by north american arenaviruses. | at least five new world (nw) arenaviruses cause hemorrhagic fevers in south america. these pathogenic clade b viruses, as well as nonpathogenic arenaviruses of the same clade, use transferrin receptor 1 (tfr1) of their host species to enter cells. pathogenic viruses are distinguished from closely related nonpathogenic ones by their additional ability to utilize human tfr1 (htfr1). here, we investigate the receptor usage of north american arenaviruses, whose entry proteins share greatest similari ... | 2014 | 24920811 |
| structural basis for receptor selectivity by the whitewater arroyo mammarenavirus. | whitewater arroyo virus belongs to the "new world" group of mammarenaviruses that reside in rodent reservoirs and are prevalent in north and south americas. clades b and a/b of new world mammarenaviruses use transferrin receptor 1 (tfr1) for entry. while all of these viruses use rodent-derived tfr1 orthologs, some can also use the human-tfr1 and thereby infect humans. although we have structural information for tfr1 recognition by pathogenic virus, we do not know what the structural differences ... | 2017 | 28736175 |