| botanicals and their bioactive phytochemicals for women's health. | botanical dietary supplements are increasingly popular for women's health, particularly for older women. the specific botanicals women take vary as a function of age. younger women will use botanicals for urinary tract infections, especially vaccinium macrocarpon (cranberry), where there is evidence for efficacy. botanical dietary supplements for premenstrual syndrome (pms) are less commonly used, and rigorous clinical trials have not been done. some examples include vitex agnus-castus (chastebe ... | 2016 | 27677719 |
| the effects of fruit juices and fruits on the absorption of iron from a rice meal. | the effects of the chemical composition of fruit juices and fruit on the absorption of iron from a rice (oryza sativa) meal were measured in 234 parous indian women, using the erythrocyte utilization of radioactive fe method. the corrected geometric mean fe absorptions with different juices varied between 0.040 and 0.129, with the variation correlating closely with the ascorbic acid contents of the juices (rs 0.838, p less than 0.01). ascorbic acid was not the only organic acid responsible for t ... | 1987 | 3593665 |
| long-term effects of the rhapontic rhubarb extract err 731® on estrogen-regulated targets in the uterus and on the bone in ovariectomized rats. | the efficacy of err 731(®), a commercially available extract isolated from rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study. further a recent preclinical study excluded unwanted side effects on the endometrium by showing a lack of stimulation of proliferation marker genes by err 731(®) or its constituents in the 3-day uterotrophic assay. the present study aimed at further substantiating the ... | 2012 | 21946530 |
| metabolism of sulphonated anthraquinones in rhubarb, maize and celery: the role of cytochromes p450 and peroxidases. | sulphonated anthraquinones are precursors of many synthetic dyes and pigments, recalcitrant to biodegradation, and thus contaminating many industrial effluents and rivers. in the development of a phytotreatment to remove sulphonated aromatic compounds, rhubarb (rheum rhaponticum), a plant producing natural anthraquinones, as well as maize (zea mays) and celery (apium graveolens), plants not producing anthraquinones, were tested for their ability to metabolise these xenobiotics. plants were culti ... | 2009 | 19768461 |
| trans-resveratrol alone and hydroxystilbenes of rhubarb (rheum rhaponticum l.) root reduce liver damage induced by chronic ethanol administration: a comparative study in mice. | the hepatoprotective effects and pharmacokinetics of trans-resveratrol and hydroxystilbenes of the garden rhubarb (rheum rhaponticum l., r. rhaponticum) root ethanol extract were studied. ethanol was administered to male balb/c mice for 35 days in an inhalation chamber. during this time vehicle, trans-resveratrol (20 mg/kg per day) or r. rhaponticum extract was intraperitoneally (i.p.) administered and mice were sacrificed for the collection of liver and blood. in an additional experiment, the l ... | 2009 | 19067386 |
| long-term toxicity studies in dogs support the safety of the special extract err 731 from the roots of rheum rhaponticum. | the special extract err 731 from the roots of rhapontic rhubarb has been regularly prescribed for women with menopausal symptoms since 1993. as its constituents belong to the class of natural hydroxystilbenes, concerns have been raised about possible health risks similar to those known for the estrogenic diethylstilbestrol. to demonstrate the safety of the medical use of err 731, the extract was tested in long-term toxicity studies in dogs. in two independent studies, male and female beagle dogs ... | 2008 | 18267351 |
| anti-helicobacter pylori activity of plant extracts traditionally used for the treatment of gastrointestinal disorders. | the antibacterial activity of plant extracts obtained from bixa orellana l., chamomilla recutita l., ilex paraguariensis a. st.-hil., malva sylvestris l., plantago major l. and rheum rhaponticum l. has been evaluated against two reference strains and eleven clinical isolates of helicobacter pylori. all the plant species chosen are used in popular brazilian cuisine and folk medicine in the treatment of gastrointestinal disorders. initial screening was made by the disk diffusion test and then mini ... | 2010 | 24031496 |
| activation of estrogen receptor-beta by a special extract of rheum rhaponticum (err 731), its aglycones and structurally related compounds. | the special extract err 731 from the roots of rheum rhaponticum is the major constituent of phytoestrol n which is used for the treatment of climacteric symptoms in menopausal women. however, the molecular mode of action of err 731 was unknown. for the first time, err 731 and its aglycones trans-rhapontigenin and desoxyrhapontigenin were investigated with regard to the activation of the estrogen receptor-alpha or estrogen receptor-beta (eralpha, erbeta). the related hydroxystilbenes cis-rhaponti ... | 2007 | 17692514 |
| antimycobacterial effect of extract and its components from rheum rhaponticum. | the global threat of tuberculosis demands the search for alternative antimycobacterial drugs. the present study examined roots and petioles from rheum rhaponticum for antimycobacterial activity. crude methanol extracts and eight phenolic compounds isolated by preparative column chromatography were tested against mycobacterium tuberculosis h37ra and m. bovis using the broth dilution method. the extract from roots and its components, such as rhaponticin, deoxyrhaponticin, resveratrol, barbaloin, a ... | 2013 | 23513971 |
| effects of the special extract err 731 from rheum rhaponticum on estrogen-regulated targets in the uterotrophy model of ovariectomized rats. | a recent clinical study with a two-year application of the extract err 731 from rheum rhaponticum demonstrated its efficacy and potentially suggested it safety regarding unwanted endometrial side effects. the aim of the present study is to provide experimental proof for the latter observation in a preclinical experimental animal model by assessing dose-dependent effects of err 731 - either alone or in combination with estradiol (e2) - on growth and proliferation in the uterus of ovariectomized ( ... | 2009 | 19808094 |
| unexpectedly high susceptibility of micropropagated rhubarb (rheum rhaponticum l.) to spot disease caused by ramularia rhei. | rapid, large-scale micropropagation of a rheum rhaponticum (rhubarb) breeding line, selected for the absence of autumn dormancy, produces changes typical of somaclonal variation. among these is enhanced susceptibility to foliar infection by the spot disease pathogen ramularia rhei, with consequential increased spore production on infected leaves. this provides an increased level of inoculum in the late season, leading to commercially unacceptable petiole spotting as spores are washed from the la ... | 2005 | 16363362 |
| subtype-specific activation of estrogen receptors by a special extract of rheum rhaponticum (err 731), its aglycones and structurally related compounds in u2os human osteosarcoma cells. | the special extract err 731 from the roots of rheum rhaponticum is the major constituent of phytoestrol n which is used for the alleviation of menopausal symptoms. recently, we demonstrated that err 731 and its aglycones trans-rhapontigenin and desoxyrhapontigenin as single test substances do not activate the estrogen receptors-alpha (eralpha) in human endometrial adenoarcinoma cells. however, these substances together with the structurally related hydroxystilbenes cis-rhapontigenin, resveratrol ... | 2007 | 17935960 |
| dietary rhubarb (rheum rhaponticum) stalk fibre does not lower plasma cholesterol levels in diabetic rats. | rhubarb (rheum rhapontiam) stalk fibre was previously shown to be hypolipidaemic under clinical and experimental conditions. the present study was undertaken to investigate whether rhubarb stalk fibre has a hypolipidaemic effect under diabetic conditions. two models of diabetic rats were used: streptozotocin-induced diabetic rats, and diabetes-prone bb (bbdp) rats. the plasma cholesterol and triacylglycerol concentrations were elevated after the onset of diabetes in bbdp rats, but not in sterpto ... | 2003 | 12575904 |