| [effects of artificial cultured panax notoginseng cell on cardiovascular system]. | alcoholic extract from artificial cultured panax notoginseng cell (scc) ip has been found conducive to increasing the resistance of mice to anoxia. in vitro it helps to increase the outflow of coronary vessels, decrease the heart rate, inhibit the constriction of aortic strip stimulated by nor-epinephrine and relax spasmodic constriction of ileum smooth muscles markedly. scc powder suspension on po administration can contract bleeding and coagulation time. the pharmacologic activities of scc are ... | 1992 | 1418584 |
| [a preliminary survey on zhuang nationality medicinal crops at traditional herbs market of jingxi county in guangxi zhuang autonomous region]. | this paper reports an investigation and study on the zhuang nationality medicinal crops available on the traditional herbs market in jingxi county of guangxi zhuang autonomous region. there are 380 species belonging to 129 families and 322 genus, among which notably embelia parviflora, malus doumeri, panax notoginseng, polygala fallax, etc. this study may serve as a reference for exploitation and utilization of the zhuang nationality medicinal herbs resources. | 1992 | 1524671 |
| [research on the plant of panax notoginseng]. | | 1985 | 2938783 |
| [saponins in fruits pedicels of panax notoginseng (burk.). f.h. chen]. | six saponins were isolated from the fruit pedicels of panax notoginseng for the first time. they were identified as ginsenoside-rc, -rb3, -re, notoginsenoside-fe, -r1 and gypenoside ix by chemical and spectroscopic analysis. | 1992 | 1418533 |
| calcium antagonistic action of saponins from panax notoginseng (sanqi-ginseng). | | 1987 | 3448392 |
| [effects of panax notoginseng saponins on monophasic action potentials of heart and automaticity and contractility of isolated atria]. | the effects of panax notoginseng saponins (pns) on monophasic action potentials (map) recorded from the myocardial surface by means of contact electrode were studied in 30 open-chest rabbits. the mapa was increased and mapd50, mapd90 were prolonged with pns (100, 200 mg.kg-1, iv), while the vmax remained unchanged. pns (300-1200 micrograms.ml-1) inhibited the automaticity of isolated guinea pig right atria and the contractility of the left atria. the positive inotropic action of ouabain (0.2 mum ... | 1992 | 1302443 |
| [comparative effects of panax notoginseng saponins, verapamil, and norepinephrine on cerebral circulation in anesthetized rats and rabbits]. | in urethane-anesthetized new zealand rabbits, mean blood pressure (mbp) and cerebrovascular resistance (cvr) fell by 27-47% and 11-17% (p < 0.05), respectively after panax notoginseng saponins (pns) 20-80 mg.kg-1 i.v. verapamil (ver) 30 micrograms.kg-1 i.v. showed similar effects, but norepinephrine (ne) 30 micrograms.kg-1 i.v. showed opposite effects. pns and ver reduced the mbp and cvr in sodium pentobarbital-anesthetized wistar rats. the actions of pns and ver on cerebral blood flow (cbf) wer ... | 1992 | 1302439 |
| [isolation and identification of sanchinoside b1 and b2 from rootlets of panax notoginseng (burk.) f. h. chen]. | | 1985 | 4072700 |
| [saponins in the fruit pedicels of panax notoginseng (burk.) f.h. chen (continue)]. | six saponins were isolated from the fruit pedicels of panax notoginseng. five of them were identified as gypenoside-xvii, -xv, ginsenoside-rb1, and notoginsenoside-fc, -fa on the basis of chemical methods, spectroscopic analysis and comparison with authentic standards. quantitative determination of the major saponins in fruit pedicels from the plant was made by thin layer chromatography-densitometry. | 1992 | 1294178 |
| [effect of panaxatriol saponins isolated from panax notoginseng (pts) on myocardial ischemic arrhythmia in mice and rats]. | pts, one of the major effective components of panax notoginseng was found to exert remarked antiarrhythmic activities on coronary artery ligation induced ischemic and reperfused arrhythmias in rats. pts also reduced the size of myocardial infarct. for i.v. cacl2-ach induced atrial fibrillation and/or flutter in mice, pts produced a significant protective effect. in addition, pts showed an action of prolonging the life under the condition of normobaric hypoxia. | 1992 | 1293932 |
| [effect of total saponins of panax notoginseng on adrenocortical function of rats and guinea pigs]. | | 1984 | 6232822 |
| [studies on film-covered soil setting seedling of panax notoginseng (burk.) f.h. chengfu]. | film-covered soil setting seedling can markedly raise the yield of seedling and seedling establishment of panax notoginseng, thus providing higher economic benefit. the increase of yield in trial plots was about 8.82%-24% higher than the control. | 1992 | 1292489 |
| [studies on the flavonoids from the leaves of panax notoginseng (burk.) f. h. chen]. | | 1987 | 3446380 |
| [studies on anti-arrhythmia effects of panaxatriol saponins isolated from panax notoginseng]. | | 1988 | 3421105 |
| [sapogenins in the flower buds of panax notoginseng]. | | 1984 | 6242382 |
| [effect of sapogenins from the leaves of panax notoginseng on migraine]. | | 1988 | 3248333 |
| [negative chronotropic and inotropic effects of panax notoginseng saponins]. | | 1988 | 3218533 |
| [depressant actions of panax notoginseng saponins on vascular smooth muscles]. | | 1988 | 3188952 |
| [effects of panax notoginseng saponins on hemorrhagic shock in rabbits]. | | 1988 | 3188935 |
| [pharmacological studies on notoginseng saponins isolated from the fibrous root of panax notoginseng]. | | 1987 | 2957098 |
| [anti-inflammatory effects of total saponins of panax notoginseng]. | | 1986 | 2954374 |
| [effects of panax notoginseng saponins on cardiac action potentials and slow inward current]. | the effects of total saponins of panax notoginseng (pns) on contraction force, normal and slow response action potentials and slow inward current of guinea pig papillary muscles were studied by intracellular microelectrodes and voltage clamp techniques. the contraction force was decreased and the apd20, apd90 of normal ap were shortened in the presence of pns 1 mg/ml, while the rp, apa and vmax remained unchanged. the apa of slow ap induced with high k+ was decreased to 85% of its normal value a ... | 1989 | 2816411 |
| [effects of panax notoginseng saponin rb1 and rg1 on myocardial action potential and slow inward current]. | the effects of rb1, rg1 (purified saponin of panax notoginseng) on contraction force, action potential and slow inward current of guinea pig papillary muscles were studied by intracellular microelectrodes and voltage clamp techniques. the contraction force was decreased and the apd20 was shortened in the presence of rb1 1 mg/ml, while the rp, apa and vmax remained unchanged. the amplitude of isi was decreased from a peak value of 9.8 +/- 1.6 to 7.3 +/- 3.4 microa after 20 min perfusion with rb1 ... | 1989 | 2641849 |
| establishment of panax notoginseng tissue culture. | calli were induced from panax notoginseng roots, tubers, stems, petioles, leaves, and flower buds, and preliminary identification of medicinal compounds in the callus was carried out by tlc, using subcultured sixth-generation calli. the results demonstrated that callus was capable of synthesizing saponins, including ginsenosides rb1, rg1, and rh1. the saponin content (5.33%, d.w.) in the callus was higher than that in intact plants (4.25%, d.w.). callus also produced a larger amount of sapogenin ... | 1989 | 2491311 |
| [protective effects of panax notoginseng saponins on experimental myocardial injury induced by ischemia and reperfusion in rat]. | effects of total saponins of panax notoginseng (pns) and purified ginsenosides rb1 and rg1 from pns on myocardial injury induced by cardiac ischemia and reperfusion were studied with rat hearts in situ and in vitro. in pentobarbital-anesthetized rats, pns pretreatment (100 and 200 mg/kg) provided significant reduction in myocardial infarct size after left descending coronary artery ligation (40 min) and reperfusion (120 min) in comparison with the control. pns 12.5 and 25 mg/l, rb1 10 mg/l, and ... | 1990 | 2403009 |
| [effects of total saponins of panax notoginseng on increasing pgi2 in carotid artery and decreasing txa2 in blood platelets]. | total saponins of panax notoginseng (pns) were given orally 100 mg/(kg.d) to rabbit for 8 wk. aortic atherosclerotic plaque formation was restrained as compared to the control group. radioimmunoassay was used to investigate the effects of pns on the contents of prostacyclin in carotid artery and thromboxane a2 in blood platelets of rat. oral administration of pns 25,50,100 mg/(kg.d) for 10 d, the caused an increase of prostacyclin in carotid artery and a decrease of thromboxane a2 in blood plate ... | 1990 | 2119543 |
| [effects of total saponins of panax notoginseng on ca2+ influx into myocardial cells]. | using simultaneous recording of action potential (ap) and contractile force (fc) in right ventricle papillary muscle of guinea pig and measurement of 45ca uptake by cultured myocardial cells of neonatal rat, the effects of total saponins of panax notoginseng (pns) on the ca2+ influx into myocardial cells were studied. the duration of the fast ap was shortened, fc was decreased and the maximal upstroke velocity and amplitude of the slow ap were depressed by pns. the 45ca uptake by cultured myocar ... | 1990 | 1965091 |
| [hypoglycemic effect of sanchinoside c1 in alloxan-diabetic mice]. | sanchinoside c1 (ginsenoside rg1), one of the major effective components of panax notoginseng, was reported to be effective in lowering glucose-induced hyperglycemia and synergizing the action of insulin in normal animals. the present study was aimed at investigating its effects on diabetic animals and comparing them with that of insulin. the results showed that sanchinoside c1 was able to lower plasma glucose level in alloxan-diabetic mice. the action was strengthened with repeated administrati ... | 1991 | 1950574 |
| immunomodulating chinese herbal medicines. | traditional chinese medicine always pays close attention to the strengthening of the patient's general resistance against illness, there are many chinese herbs used for thousands of years are considered as tonics. animal experiments and modern clinical trails have shown that quite a number herbs are immunologically active, and most of the tonics are excellent immunomodulating agents, such as polysaccharides or saponins isolated from astragalus mongholicus, acanthopanax senticosus and panax notog ... | 1991 | 1841992 |
| [blood-lipid decreasing action of total saponins of panax notoginseng (burk.) f.h. chen]. | blood-lipid decreasing action of total saponins of panax notoginseng was studied. the results showed that after the saponins were given po 100 mg/kg and 200 mg/kg to rats and quails, two high lipid model animals, for seven days, their tch and tg were evidently decreased (p < 0.05). | 1993 | 8274218 |
| [separation and identification of main medicinal saponin components from mass cell cultures of panax notoginseng (burk) f. h. chen]. | five main saponins were separated from the cell cultures of panax notoginseng (burk) f. h. chen. they were sanchinoside rb1, re, r1, rg1 and rh1 identified by tlc, hplc, ir, m. p., 13cnmr and ei-ms. saponin components of the cell cultures were almost the same as those of the cultivated plants. but the content of saponins was different between the cell cultures and the cultivated plants. saponin extraction and separation procedure suitable for the cell cultures has to be different from that for t ... | 1991 | 1823984 |
| reduction of cellular damage induced by cerebral ischemia in rats. | a model of incomplete cerebral ischemia involving bilateral ligation of the common carotid arteries in rats, was used to examine the potential of a chinese herbal preparation and of nifedipine to reduce cell damage following cerebral ischemia. the herbal preparation contained ginsengosides and extracts of panax notoginseng, ligusticum chuanxiong hort., carthamus tinctorius l. and salvia militorrhiza bge. histological evidence of cell damage and the formation of peroxidation products were both re ... | 1991 | 1791915 |
| effects of saponins of panax notoginseng on sodium-potassium-adenosine triphosphatase and calcium-magnesium-adenosine triphosphatase. | rat brain synaptosomal na(+)-k(+)-atpase was activated by panax notoginseng (pns, 0.1-1.0 mg.ml-1), fraction rb1 (25-200 micrograms.ml-1), and fraction rg1 (50-200 micrograms.ml-1). activating rates were respectively 84-227%, 12-48%, and 12-22%. results implied that rb1 and rg1 were not the major components of pns, which were responsible for the activating effects. ca(2+)-mg(2+)-atpase was inhibited by pns (0.1-1.0 mg.ml-1) and rb1 (100-200 micrograms.ml-1), but not by rg1. it was proposed that ... | 1991 | 1668565 |
| sanchinan-a, a reticuloendothelial system activating arabinogalactan from sanchi-ginseng (roots of panax notoginseng). | | 1987 | 3602143 |
| cardiovascular pharmacology of panax notoginseng (burk) f.h. chen and salvia miltiorrhiza. | the cardiovascular pharmacology of two chinese herbs, salvia miltiorrhiza (sm) and panax notoginseng (burk) f. h. chen (png) were studied both in vivo and in vitro. extracts of both herbs suppressed systemic blood pressure in albino rats and rabbits, an effect which was blocked or reversed by atropine, propranolol, and chlorpheniramine plus cimetidine. this reversed hypertension was blocked by phenoxybenzamine. these results indicate that these herbs have multiple effector sites in the cardiovas ... | 1986 | 3799531 |
| [sapogenins from rootlets of panax notoginseng]. | | 1984 | 6242107 |
| [effect of panax notoginseng on experimental disseminated intravascular coagulation (dic)]. | | 1984 | 6502462 |
| [hemodynamic effects of san chi (panax notoginseng) root, leaf, flower and saponins on anesthetized dogs]. | | 1983 | 6679973 |
| effect of notoginsenoside r1 on the synthesis of components of the fibrinolytic system in cultured smooth muscle cells of human pulmonary artery. | we have previously reported that notoginsenoside r1 (ng-r1) increases the synthesis of tissue-type plasminogen activator (t-pa) and decreases plasminogen activator inhibitor-1 (pai-1) activity in cultured human endothelial cells from different vascular sources. it was the aim of this study to investigate whether the effect of ng-r1 on the synthesis of components of the fibrinolytic system is also operative in another cell type of the blood vessel wall, the smooth muscle cell. therefore cultured ... | 1997 | 9220151 |
| [effects of general saponin of panax notoginseng and sanchinoside c1 on blood sugar in experimental animals (author's transl)]. | | 1982 | 7102339 |
| [studies of the effects of gynura segetum and panax notoginseng on the ultrastructure of platelets in guinea-pigs]. | | 1982 | 7168330 |
| [observation of therapeutic effect by combined administration of salvia miltiorrhiza, ligustrazine and panax notoginseng on late hemorrhagic shock of rabbits]. | to explore the therapeutic mechanism of salvia miltiorrhize, ligustrazine and panax notoginseng in treating late hemorrhagic shock in rabbit. | 1997 | 9863115 |
| [studies on antihemorrhagic principles in the crude drugs for hemostatics. ii. on antihemorrhagic principle in sanchi ginseng radix (author's transl)]. | | 1981 | 7320834 |
| [chemical studies of san-chi panax notoginseng (burk.) f. h. chen. i. studies on the constituents of san-chi root hairs]. | | 1980 | 7457155 |
| [clinical and experimental study of improving left ventricular diastolic function by total saponins of panax notoginseng]. | to investigate the effect of total saponins of panax notoginseng (tspns) on left ventricular diastolic function in patients with essential hypertension (eh) and possible mechanism. | 1997 | 10322816 |
| effects of panax notoginseng saponins on receptor-operated ca2+ channels in vascular smooth muscle. | the effects of saponins of panax notoginseng (pngs) on the alpha-adrenoceptor agonists-induced contractile responses and ca2+ movement were studied in dog mesenteric artery (ma) and saphenous vein (sv). pngs reduced the contractions and the 45ca influx (from 0.36 +/- 0.03 to 0.14 +/- 0.05 mumol.g-1 wet strip) induced by phenylephrine (phe) without effect on kcl-induced contraction and 45ca influx which were nearly completely inhibited by nifedipine 0.1 mumol.l-1. pngs did not change the 45ca eff ... | 1994 | 7717059 |
| effects of panax notoginseng saponins on myocardial adenosinetriphosphatase. | effects of total panax notoginseng saponins (pns) and panax notoginseng saponin monomers rb1 and rg1 (rb1, rg1) on total atpase and na(+)-k(+)-exchanging atpase of guinea pig heart were studied. it was found that pns inhibited the total myocardial atpase, but had no significant effect on the myocardial na(+)-k(+)-exchanging atpase. the total atpase was inhibited by rg1, and more clearly by rb1. the automaticity and contractility of isolated guinea pig atria were inhibited by rb1. rg1 decreased t ... | 1994 | 7801779 |
| the effect of chinese hepatoprotective medicines on experimental liver injury in mice. | the purpose of this study was to compare the hepatoprotective effects of seven chinese herbal compounds/mixtures on four known hepatotoxicants in mice. these compounds include fulvotomentosides oleanolic acid, total saponins of panax japonicus (jgs), total saponins of panax notoginseng (ngs), sweroside, oxymatrine, and dimethyl dicarboxylate biphenyl (ddb). all have previously been reported to exhibit hepatoprotective effects. acute liver injury was produced in male cf-1 mice by ccl4, acetaminop ... | 1994 | 7934088 |
| [effects of panaxadiol saponins isolated from panax notoginseng on intracellular and extracellular calcium]. | panaxadiol saponins (pds) contain saponins panax notoginseng b1 and e. the spontaneous beating induced by isoproterenol in isolated rat right atria and the increase of contractile force induced by ca2+ in isolated guinea pig colon were inhibited by pds 75 and 150 micrograms.ml-1, respectively and perhexiline 6.25 and 12.5 mumol.l-1, respectively. it suggested that pds could block the potential-dependent and receptor-operated calcium channel in smooth muscle. pds 150 micrograms.ml-1 and perhexili ... | 1993 | 8010067 |
| effect of notoginsenoside r1 on the synthesis of tissue-type plasminogen activator and plasminogen activator inhibitor-1 in cultured human umbilical vein endothelial cells. | among other chinese herb drugs, panax notoginseng is used to treat cardiovascular diseases. to elucidate any possible effects of this drug on the hemostatic system in vitro, we analyzed the influence of one of its major active constituents on fibrinolytic parameters of cultured human umbilical vein endothelial cells (huvecs). when confluent cultures of huvecs (passages 2 to 3) were conditioned with purified notoginsenoside r1 (nr1), a dose- (0.01 to 100 micrograms nr1/ml) and time-dependent incr ... | 1994 | 8018658 |
| [effects and mechanism of total saponins of panax notoginseng on anti-inflammation and analgesia]. | in this study the effects of total saponins of panax notoginseng (tspn) and electroacupuncture (ea) were compared. liquid paraffin was intraperitoneally injected (0.1 ml/mouse) to establish the animal model with inflammation. the mice were randomly divided into 4 groups with different treatments for 7 days: ea group, tspn group (100 mg.kg intraperitoneal administration), naloxone (nx) plus tspn group and ea plus tspn group. the pain threshold was measured by a detector (eq-9e) and the nitroblue ... | 1994 | 8044000 |
| [clinical effect and experimental study of xijian tongshuan pill]. | xijian tongshuan pill (xjts), consisted of siegesbeckia orientalis, moschus moschiferus, hirudo nipponica, prunus persicae, carthamus tinctoruis, ligusticum wallichi, panax notoginseng, angelica sinensis, borneolum, etc, were used in treating 70 patients with cerebral thrombosis. the marked effective rate was 82.9%, total effective rate was 96.7%. in control group a, dextranum and venoruton were used, in control group b cyclandelate capsule were used. the marked effective rate was 61.7% and 61.1 ... | 1994 | 8044010 |
| effect of panax notoginseng saponins on increased proliferation of cultured aortic smooth muscle cells stimulated by hypercholesterolemic serum. | panax notoginseng saponins (pns) was extracted from a chinese herb medicine. after preparation of cultured aortic smooth muscle cell (smc) from primary aortic explants, the cytotoxicity of hypercholesterolemic serum (hcs) for cultured cells was determined by trypan blue exclusion test, and [3h]thymidine incorporation and cell numbers were counted at the same time. the results showed that hcs (0.5 mg cholesterol.ml-1) increased the incorporation of [3h]thymidine into cultured cells (3722 +/- 440 ... | 1993 | 8249623 |
| [effects of panaxatriol saponins (pts) isolated from panax notoginseng on the action potential and delayed rectifier current (ix) in sheep cardiac purkinje fibers]. | the electrophysiological effects of pts in sheep cardiac purkinje fibers were studied. pts was shown to increase the duration of action potential (apd30, apd50 and apd90) at the concentrations of 2.5 micrograms/ml and 5.0 micrograms/ml. however, the amplitude of action potential (apa) remained unchanged. the result of using double microelectrode voltage clamp method showed that pts (1.25-10.0 micrograms/ml) depressed the delayed (outward) rectifier current (ix) in time- and dose-dependent manner ... | 1993 | 8328288 |
| [a prospective clinical study on reversion of 200 precancerous patients with hua-sheng-ping]. | 200 precancerous patients were treated by the drug hua-sheng-ping, the process was monitored by endoscopic histo-pathologic examination, and biochemical criteria. results: the total effective rate was 95.5%, which was higher than that of control group (57%), p < 0.01. the recipe is composed of some medicinal herbs such as chrysanthemum morifolium, glycyrrhiza uralensis, panax notoginseng. it is indicated for syndromes such as spleen-stomach asthenic cold etc. and has been proved to be an effecti ... | 1993 | 8339031 |
| effects of panax notoginseng saponins on posthypoxic cell damage of neurons in vitro. | to study cerebral protective mechanism of panax notoginseng saponins (pns). | 1995 | 8701752 |
| [anti-arrhythmic effect of total saponins of panax notoginseng]. | | 1984 | 6087608 |
| [an analysis of ddt residue in panax notoginseng (author's transl)]. | | 1981 | 6211266 |
| [analgesic and central nervous system inhibiting effects of total saponins extracted from the leaves of panax notoginseng]. | | 1984 | 6237766 |
| [cardiac and hemodynamic effect of total saponins of panax notoginseng]. | | 1984 | 6239510 |
| vascular effects of selected antihypertensive drugs derived from traditional medicinal herbs. | 1. the pharmacological actions of the active ingredients extracted or purified from two selected traditional chinese medicinal plants on vascular smooth muscles are briefly reviewed. the active ingredients of these herbal drugs include tetrandrine (tet) and total ginseng saponins (tgs). these natural products have been clinically used in china for the treatment of cardiovascular diseases due to their vasodilatory and antihypertensive actions. 2. studies from this laboratory have confirmed previo ... | 1995 | 9072399 |
| bioactive saponins and glycosides. viii. notoginseng (1): new dammarane-type triterpene oligoglycosides, notoginsenosides-a, -b, -c, and -d, from the dried root of panax notoginseng (burk.) f.h. chen. | the glycosidic fraction from the dried roots of panax notoginseng (burk.) f.h. chen was found to show protective effect on liver injury induced by d-galactosamine and lipopolysaccharide. from the glycosidic fraction with hepatoprotective effect, nine new dammarane-type triterpene oligoglycosides, notoginsenosides-a, -b, -c, -d, -e, -g, -h, -i, and -j and an acetylenic fatty acid glycoside, notoginsenic acid beta-sophoroside, were isolated together with fourteen known dammarane-type triterpene ol ... | 1997 | 9214709 |
| [progress in the study on protective effect of saponins panax notoginseng on ischemic brain damage]. | | 1996 | 9387754 |
| extracellular ca2+ regulates the respiratory burst of human neutrophils. | the role of extracellular calcium in the activation of respiratory burst in human neutrophils was studied by using the receptor agonist, n-formyl-methionyl-leucyl-phenylalanine (fmlp), and the activator of protein kinase c phorbol myristate acetate (pma). the level of intracellular free calcium was measured by using both cell suspensions and single cells in the presence and absence of extracellular calcium. the ca2+-atpase inhibitor, thapsigargin, was used to activate higher ca2+ influx, while a ... | 1998 | 9739175 |
| [effect of panax notoginseng saponin on ca2+, cam in craniocerebral injury]. | to explore the change of nerve cell ca(2+)-overload, ca(2+)-cam and the effect of panax notoginseng saponin (pns) on it in craniocerebral injury. | 1999 | 11783273 |
| effect of saponins of panax notoginseng on synaptosomal 45ca uptake. | to explore the calcium uptake antagonism of saponins of panax notoginseng (pns). | 1997 | 10072935 |
| improvement of early postburn cardiac function by use of panax notoginseng and immediate total eschar excision in one operation. | cardiac dysfunction development in the early stage postburn has been an important problem in burn treatment. however, no effective therapies are available for use in clinical practice. in this study, we sought to determine whether early total eschar excision (eee) in one operation and the traditional chinese herb panax notoginseng (pns) would be helpful in improving early postburn cardiac function. 160 wistar rats were randomly divided into burn (burn group, n = 50), burn treated with eee (eee g ... | 1999 | 10090382 |
| effect of panax notoginseng extracts on inferior sperm motility in vitro. | the purpose of this study was to investigate the effects of panax notoginseng extracts on inferior sperm motility in vitro. semen samples were collected from 23 patients with sperm motility between 20% and 40%. the sperm count was over 20 x 10(6)/ml in accordance with the world health organization standard. 1.0 mg/ml and 2.0 mg/ml of panax notoginseng extracts including aqueous extract, n-butanol extract, and polysaccharide fraction on sperm motility and progression were evaluated by computer as ... | 1999 | 10354824 |
| effects of four herbal extracts on adjuvant-induced inflammation and hyperalgesia in rats. | to evaluate the effects of four herbal medicine extracts on a rat model of inflammatory hyperalgesia. design/interventions: inflammation was induced by injecting complete freund's adjuvant (cfa) into one hindpaw of each rat. four herbs that are routinely prescribed in traditional chinese medicine for treatment of pain were used: duhuo (radix angelicae pubescentis), bai jiang cao (patriniae herba cum radice), yan hu suo (rhizoma corydalis) and sanqui (panax notoginseng). the crude water extracts ... | 1999 | 10537242 |
| anti-carcinogenic activity of the roots of panax notoginseng. ii. | the extract of the roots of panax notoginseng (araliaceae) exhibited a significant anti-tumor-promoting activity on two-stage carcinogenesis of mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (dmba) as an initiator and a mycotoxin, fumonisin b1, as a non-12-o-tetradecanoylphorbol-13-acetate (non-tpa) type promoter. further, the extract exhibited the anti-tumor-initiating activity on two-stage carcinogenesis of mouse skin tumors induced by a nitric oxide donor, (+/-)-(e)-methyl-2-[(e) ... | 1999 | 10549877 |
| anti-inflammatory effects of total saponins of panax notoginseng. | to study the anti-inflammatory effects of total saponins of panax notoginseng (pns). | 1999 | 10678152 |
| the ameliorating effects of the cognitive-enhancing chinese herbs on scopolamine-induced amnesia in rats. | ameliorating effects were investigated of the cognitive-enhancing chinese herbs administered orally for 1 week-panax ginseng (pg), panax notoginseng (png), dioscorea opposita (do), gastrodia elata (ge), salvia miltiorrhiza (sm), acorus gramineus (ag), coptis chinensis (cc), polygonum multiflorum (pm), cyperus rotundus (cr) and psoralea corylifolia (pc)-on the scopolamine (scop)-induced amnesia by using a passive avoidance task in rats. of ten chinese herbs, only pg, png, ge and cc prolonged the ... | 2000 | 10925408 |
| ustoo pc-spes surveys: review of studies and update of previous survey results. | in 1997, we resolved to survey ustoo members and other men known at that time to be taking pc-spes, a chinese herb combination that contains eight herbs: chrysanthemum, dyers woad, licorice, reishi, san-qi ginseng, rabdosia, saw palmetto, and baikal skullcap. the survey showed positive results, with respondents experiencing a decline in serum prostate specific antigen (psa), most to the undetectable range. of these patients, 88% maintained a low psa concentration, whereas 12% had a rise from nad ... | 2000 | 11062386 |
| [relationship between root rot on panax notoginseng burk. f. h. chen and its environmental conditions]. | to probe into the relationship between root rot on panax notoginseng and its environmental conditions for integrate control of the disease. | 1998 | 12242819 |
| orally administered panax notoginseng influence on rat spontaneous behaviour. | panax notoginseng root is highly prized in china for its supposed hemorheological properties. its behavioural effects are still not scientifically investigated; therefore, our preliminary study aim is to evaluate the influence of this phyto-drug on rats spontaneous behaviour. high quality p. notoginseng root dry extract has been orally administered through gastric tube for 10 days in two doses (43 and 86 mg/kg in a volume of 5 ml/kg per day) and its effects on locomotion, emotional reactivity an ... | 2000 | 11090991 |
| genetic heterogeneity of ribosomal rna gene and matk gene in panax notoginseng. | previously, 185 ribosomal rna gene and matk gene sequences of chinese herbal medicines, ginseng radix, panacis japonici rhizoma and panacis quinquefolli radix were shown to correspond with those of the original plants, panax ginseng, p. japonicus and p. quinquefolius, respectively, with the species-specific sequences especially for 18s rrna gene sequences. in p. notoginseng and its derivative, notoginseng radix, however, we found two genetic groups with respect to both gene sequences. five base ... | 2000 | 11105576 |
| [determination of organochlorine pesticide multi-residues in astragalus membranaceus (fisch.) bge. var. mongholicus (bge.) hsiao, panax notoginseng (burk.) f. h. chen and p. quin quefolium l]. | to determine 15 organochlorine pesticide residues in astragalus membranaceus, panax notoginseng and p. quinquefolium. | 2000 | 12515220 |
| isolation of a small chitinase-like antifungal protein from panax notoginseng (sanchi ginseng) roots. | an antifungal protein, with a molecular weight of 15 kda and an n-terminal sequence analogous to those of chitinases, was first isolated from the chinese medicinal material panax notoginseng, using cation exchange chromatography and affinity chromatography. the protein was adsorbed on cm-cellulose, affi-gel blue gel and mono s. it exerted antifungal activity against coprinus comatus, fusarium oxysporum and mycosphaerella arachidicola but not against rhizoctonia solani. the protein was devoid of ... | 2001 | 11311860 |
| effects of ginsenoside rb2 and rc on inferior human sperm motility in vitro. | the purpose of the study was to investigate the effects of two constituents of panax notoginseng flower extract, ginsenoside rb2 and rc, on human sperm motility and progression in vitro. semen samples were collected from 20 patients with sperm motility between 20% and 40% of normal. all samples had sperm counts of over 20 million per milliliter, in accordance with the world health organization standard. sperm were separated by a percoll discontinuous gradient technique, and divided into a percol ... | 2001 | 11321473 |
| panax notoginseng saponins attenuated cisplatin-induced nephrotoxicity. | to study protective effects of panax notoginseng saponins (pns) against cisplatin-nephrotoxicity. | 2000 | 11324427 |
| isolation of a novel thermolabile heterodimeric ribonuclease with antifungal and antiproliferative activities from roots of the sanchi ginseng panax notoginseng. | an isolation procedure, consisting of ion exchange chromatography on cm-sepharose, affinity chromatography on affi-gel blue gel, and fast protein liquid chromatography on mono s, was utilized to purify a base-nonspecific, heterodimeric ribonuclease (rnase) with diverse activities from roots of the sanchi ginseng panax notoginseng. the rnase is unique in that it consists of two different nonglycoprotein subunits with a molecular weight of 27 and 29 kda, respectively. the latter subunit is charact ... | 2001 | 11444859 |
| effects of panax notoginseng saponin rg1 on cardiac electrophysiological properties and ventricular fibrillation threshold in dogs. | to study the effects of rg1 isolated from saponins of panax notoginseng on cardiac electrophysiological properties and ventricular fibrillation threshold (vft). | 1995 | 8701769 |
| immunostimulating polysaccharides from panax notoginseng. | the main purpose of this study is to prepare and characterize polysaccharides from panax notoginseng, investigate their effects on immune system in vitro in order to find new immunostimulants for the prevention and supporting treatment of infection and immunodeficiency related diseases. | 1996 | 8865311 |
| studies on the neuroexcitotoxin beta-n-oxalo-l-alpha,beta-diaminopropionic acid and its isomer alpha-n-oxalo-l-alpha,beta-diaminopropionic acid from the root of panax species. | the neuroexcitotoxic nonprotein amino acid, beta-n-oxalo-l-alpha,beta-diaminopropionic acid (beta-n-odap) was found in panax species such as panax ginseng 'c.a. meyer' (cultivated in northeastern china), panax quinquefolius (l), panax notoginseng 'f.h. chen' (cultivated in southwestern china), korean red ginseng and jilin (china) red ginseng. beta-n-odap was verified to be a natural substance, and its isomer alpha-n-oxalo-l-alpha,beta-diaminopropionic acid (alpha-n-odap) is very likely an artifa ... | 1996 | 8907498 |
| [comparative study on effect of panax notoginseng and ticlid in treating early diabetic nephropathy]. | to explore the ameliorative effect and mechanism of panax notoginseng (png) and ticlid in treating early diabetic nephropathy (dn). | 1998 | 11475719 |
| [effects of cultivating measures on root rot of panax notoginseng]. | to probe into the effects of cultivating measures on root rot of panax notoginseng for the integrate control. | 2000 | 12575264 |
| effects of panax notoginseng saponins on vascular endothelial cells in vitro. | to investigate the inhibition of endothelium-dependent in vitro vascular relaxation induced by the total saponins (gensenosides) from panax notoginseng (pns) and the effect of pns on the cytosolic ca2+ concentration on cultured bovine pulmonary artery endothelial cells. | 2000 | 11603283 |
| bioactive saponins and glycosides. xix. notoginseng (3): immunological adjuvant activity of notoginsenosides and related saponins: structures of notoginsenosides-l, -m, and -n from the roots of panax notoginseng (burk.) f. h. chen. | new dammarane-type triterpene saponins, notoginsenosides-l, -m, and -n, were isolated from the glycosidic fraction of the dried roots of panax notoginseng (burk.) f. h. chen. their structures were elucidated on the basis of chemical and physicochemical evidence. immunological adjuvant activities of the principal notoginsenosides and related dammarane-type triterpene saponins were examined and notoginsenosides-d, -g, -h, and -k were found to increase the serum igg level in mice sensitized with ov ... | 2001 | 11724237 |
| effects of hepatocyte growth-promoting factor and panax notoginseng saponins on intrasplenic hepatocellular autotransplantation. | to increase the weight of liver tissue mass present in spleen and to shorten the regeneration period of transplanted hepatocytes by stimulating dna synthesis and protection against ischemic-reperfusion injury. | 2001 | 11743884 |
| sensitization of a tumor, but not normal tissue, to the cytotoxic effect of ionizing radiation using panax notoginseng extract. | the aim of the present study was to investigate any sensitization effect of the panax notoginseng extract (pne) and the purified saponin (rb1) on the radiation response of an experimental tumor (kht sarcoma) in mice, in comparison with any effects on a normal tissue (bone marrow). pne at a concentration of 0.1-100 mg/kg produced an increase in tumor radiosensitivity. the sensitization effect was maximal at 10 mg/kg and at 30 minutes after injection. higher doses were toxic to the bone marrow ste ... | 2001 | 11789595 |
| a validated method for quantitative determination of saponins in notoginseng (panax notoginseng) using high-performance liquid chromatography with evaporative light-scattering detection. | a gradient high-performance liquid chromatographic (hplc) method with evaporative light-scattering detection (elsd) for the determination of major saponins in a chinese traditional herbal medicine, panax notoginseng, is described. samples were analysed by means of a reverse-phase column (waters spherisorb ods-2, c-18) using acetonitrile and water under gradient conditions as the mobile phase over 60 min. the elsd used was set at an evaporating temperature of 35 degrees c and pressurized air pres ... | 2001 | 11804394 |
| synthesis of oligosaccharide derivatives related to those from sanqi, a chinese herbal medicine from panax notoginseng. | oligosaccharide derivatives from sanqi, a chinese herbal medicine derived from panax notoginseng, methyl beta-d-galactopyranosyl-(1-->3)-[alpha-l-arabinofuranosyl-(1-->6)]-alpha-d-galactopyranoside, diosgenyl beta-d-galactopyranosyl-(1-->3)-[alpha-l-arabinofuranosyl-(1-->6)]-alpha-d-galactopyranoside, and methyl beta-d-galactopyranosyl-(1-->3)-[alpha-l-arabinofuranosyl-(1-->6)]-alpha-d-galactopyranosyl-(1-->4)-beta-d-galactopyranosyl-(1-->3)-[alpha-l-arabinofuranosyl-(1-->6)]-alpha-d-galactopyra ... | 2002 | 11890886 |
| a xylanase from roots of sanchi ginseng (panax notoginseng) with inhibitory effects on human immunodeficiency virus-1 reverse transcriptase. | a xylanase with a molecular weight of 15 kda, which is lower than those of previously reported xylanases, was isolated from the roots of the medicinal herb panax notoginseng. the xylanase exhibits a temperature optimum of 50 degrees c and a ph optimum between 5 and 6. it inhibits hiv-1 reverse transcriptase with an ic(50) of 10 microm, but does not affect translation in a cell-free rabbit reticulocyte system when tested up to 70 microm. the enzyme is adsorbed on cm-cellulose, affi-gel blue gel a ... | 2002 | 12138018 |
| estrogen-like activity of ginsenoside rg1 derived from panax notoginseng. | ginsenosides have demonstrated pharmacological effects in the central nervous, cardiovascular, and endocrine systems. we hypothesize that ginsenosides might mediate some of their actions by binding to the estrogen receptor, as they share many of the protective actions of estrogen in various physiological systems. the present study is aimed to determine whether ginsenoside rg1 can act like an estrogen analog in stimulating human breast cancer cell growth as well as in the activation of estrogen r ... | 2002 | 12161497 |
| [comparison of amino acid contents in panax notoginseng from different habitats]. | to determine the contents of amino acid and study the characters of sanqi (panax notoginseng) from different habitats. | 2003 | 12795215 |
| [cerebral protective effects of some compounds isolated from traditional chinese herbs]. | to study the cerebral protective effects of some compounds isolated from traditional chinese herbs. | 1999 | 12205950 |
| [effects of rg1 on calcium channel of guinea pig ventricular myocytes]. | to evaluate the effect of rg1 (purified saponin of panax notoginseng) on l-ca2+ channel of guinea pig ventricular myocytes. | 1999 | 12205963 |
| [effect of panax notoginseng saponins combined isovolumic haemodilution on the retinal microcirculation of patients with retinal vein occlusion]. | to study the effect of panax notoginseng saponins (pns) or isovolumic haemodilution (ihd) and combination of pns with ihd on retinal microcirculation of patients with retinal vein occlusion (rvo). | 2000 | 12206008 |
| isolation of dammarane saponins from panax notoginseng by high-speed counter-current chromatography. | the chinese phytomedicinal formulation sanqi zongdai pian, traditionally prepared from crude extracts from roots of panax notoginseng (araliaceae), contains highly polar dammarane saponins which were separated at a preparative scale using high-speed counter-current chromatography (hsccc). in each operation, 283 mg methanolic extract of five tablets was separated and yielded pure 157, 17, 13 and 56 mg of ginsenoside-rb1, notoginsenoside-r1, ginsenoside-re and ginsenoside-rg1, respectively, n-hexa ... | 2003 | 12967182 |
| pananotin, a potent antifungal protein from roots of the traditional chinese medicinal herb panax notoginseng. | the roots of the sanchi ginseng, panax notoginseng, were extracted with an aqueous buffer. the extract was chromatographed on a cm-cellulose column to remove extraneous unadsorbed proteins. the adsorbed fraction was dialyzed and chromatographed on affi-gel blue gel. the adsorbed fraction was again collected, dialyzed and applied on a column of mono s. the second peak was dialyzed and chromatographed on an fplc-gel filtration superdex 75 column. an antifungal protein with an n-terminal sequence s ... | 2002 | 12451495 |