borrelia persica and b. baltazardi sp. nov.: experimental pathogenicity for some animals and comparison of the ultrastructure.the ultrastructure of cells of borrelia persica was compared with that of cells of a new isolate of barrelia (borrelia "x"). this organism (b. "x") was isolated in a region of iran where b. persica is already known to exist. the morphology of the cells of the two strains differed in mean cell length and cell diameter. cells of b. persica were covered by a regularly structured surface layer, while those of b. "x" possessed an amorphous surface coat. furthermore, the strains differed in their expe ...1979533068
[an experimental quantitative assessment of the efficiency of borrelia persica transmission by ornithodoros papillipes ticks. 1. 2 forms of borreliemia in guinea pigs].experimental borreliosis in guinea pigs caused by ticks' bites assumed two forms--typical and mild, the latter being encountered in 40% of cases. mild form significantly differs from the typical one in some indices of borreliemia: intensity, duration, time of onset and cessation, absence of fluctuations in the number of borrelia. the form is not easily diagnosed by the analysis of animal blood preparations, which should be taken into consideration in experimental and clinical practice. in mild f ...19902215365
[treatment of borrelia infected ticks (author's transl)].the ornithodorus tholozani, carrier and main reservoir of borrelia persica, causing agent of the regional recurrent fever in iran, gets rid of the infection by stuffing in blood containing a cycline type antibiotic, in an adequate concentration. the treatment efficiency is 100%, confirmed on 60 infected ticks who showed to be free from borrelia after a treatment meal, so that the crushing of their whole body, inoculated to the guinea-pig, the most sensitive animal to borrelia persica, remains al ...19827105283
[new solid culture media for growing borrelia persica and borrelia microti].a new solid means for the fast detection of borrelia persica and borrelia microti is described. generally, culture and isolation of borrelia takes about 21 days. the serological test, which is carried out more often, takes less time but it is associated with false positive reactions relatively high. however, our new solid means reduces the culture time to 72 hours, allowing to have a fast diagnosis of the disease caused by borrelia persica and borrelia microti, and to start the early treatment o ...19969768268
[survival of borrelia persica dschunkowski 1912 in the whole human blood preserved at + 4 degrees c]. 195313125009
[biology of the spirochete borrelia persica, found in the tick ornithodorus tholazani (argasinae) collected in the governorat of the western egyptian desert; comments on the distribution and ecology of the vector tick]. 195613340431
a note on the action of terramycin on a strain of spirochaeta persica in rats. 195214922483
notes on spirochaeta persica from palestine and spirochaetes of relapsing fever from the western desert (tobruk area). 194918117642
the epidemiology of tick-borne relapsing fever in iran during 1997-2006.tick-borne relapsing fever is an acute febrile and endemic disease in iran. for many reasons, the incidence of disease is on decrease, however tick-borne relapsing fever is still a health issue in the rural areas for travelers. this study was carried out during 1997-2006 to investigate the tick-borne relapsing fever in iran.200919411042
discrimination of relapsing fever borrelia persica and borrelia microtti by diagnostic species-specific primers and polymerase chain reaction-restriction fragment length polymorphism.tick-borne relapsing fever (tbrf) is endemic in africa and eurasia and attributed to different borrelia species. in the central asia and middle eastern countries, tbrf is caused mainly by borrelia persica; however, other borrelia species such b. microtti, b. latyschewii, b. baltazardi, and b. caucasica have also been described. the classic taxonomy of borrelia spp. is based on the cospeciation concept that is very complex and rather confusing. in this study, we report two dna-based methods to di ...201120586604
tickborne relapsing fever caused by borrelia persica, uzbekistan and the editor: tickborne relapsing fever (tbrf) is caused by several borrelia species and transmitted by argasid soft ticks of the genus ornithodoros. the disease is endemic to many parts of the world, especially africa (b. duttonii and b. crocidurae most prevalent), and the mediterranean basin (b. hispanica most prevalent). in eurasia, tbrf is mainly caused by b. persica (1-3). we report a patient who returned to france with b. persica infection after visiting uzbekistan and tajikistan.201121762608
detection of borrelia persica infection in ornithodoros tholozani using pcr targeting rrs gene and xenodiagnosis.relapsing fever caused by borrelia persica, is an acute tick-borne disease which is transmitted by soft ticks of ornithodoros tholozani to human.201123113113
comparison of pcr-based diagnosis with centrifuged-based enrichment method for detection of borrelia persica in animal blood samples.the mainstay of diagnosis of relapsing fever (rf) is demonstration of the spirochetes in giemsa-stained thick blood smears, but during non fever periods the bacteria are very scanty and rarely detected in blood smears by microscopy. this study is aimed to evaluate the sensitivity of different methods developed for detection of low-grade spirochetemia.201122808405
the first case of imported relapsing fever in japan.tick-borne relapsing fever (tbrf) is endemic in discrete areas throughout the world; however, a domestic or imported case of relapsing fever has not been reported in japan. here, we report the first imported case. a previously healthy 20-year-old woman presented to our hospital on october 8, 2010, because of recurrent fever and lower leg pain. before consultation, she had experienced four febrile episodes at 10-12-day intervals after returning from her stay in uzbekistan from 1 to 8 september. g ...201323857020
study on presence of borrelia persica in soft ticks in western iran.a molecular survey was conducted to investigate the presence of pathogenic borrelia persica species causing the tick borne relapsing fever (tbrf) in takistan district qazvin province, western iran.201022808396
borrelia persica infection in dogs and cats: clinical manifestations, clinicopathological findings and genetic characterization.relapsing fever (rf) is an acute infectious disease caused by arthropod-borne spirochetes of the genus borrelia. the disease is characterized by recurrent episodes of fever that concur with spirochetemia. the rf borrelioses include louse-borne rf caused by borrelia recurrentis and tick-borne endemic rf transmitted by argasid soft ticks and caused by several borrelia spp. such as b. crocidurae, b. coriaceae, b. duttoni, b. hermsii, b. hispanica and b. persica. human infection with b. persica is t ...201627160515
genome sequence of the asiatic species borrelia persica.we report the complete genome sequence of borrelia persica, the causative agent of tick-borne relapsing fever borreliosis on the asian continent. its genome of 1,784,979 bp contains 1,850 open reading frames, three ribosomal rnas, and 32 trnas. one clustered regularly interspaced short palindromic repeat (crispr) was detected.201424407639
molecular characterization of borrelia persica, the agent of tick borne relapsing fever in israel and the palestinian authority.the identification of the tick borne relapsing fever (tbrf) agent in israel and the palestinian authority relies on the morphology and the association of borrelia persica with its vector ornithodoros tholozani. molecular based data on b. persica are very scarce as the organism is still non-cultivable. in this study, we were able to sequence three complete 16s rrna genes, 12 partial flab genes, 18 partial glpq genes, 16 rrs-ilet intergenic spacers (igs) from nine ticks and ten human blood samples ...201021124792
'one health', from science to policy: examples from the israeli experience.'the concept of 'one health' aims to help bring about the integration of animal, human and environmental health for the mutual benefit of all. this multidisciplinary approach is of great importance in a variety of fields, from enhancement of breakthroughs in biomedical research, to epidemiological studies and public health policy decision-making. we demonstrate the strength embedded in this approach by using three case studies from israel. we first describe successful scientific collaboration be ...200920391389
relapsing fever borreliosis in eurasia--forgotten, but certainly not gone!tick-borne relapsing fever (tbrf) has been reported in eurasia and attributed mainly to borrelia persica, although other entities have also been described. ornithodoros tholozani is the most important tick vector, found in india and kashmir, the southern countries of the former ussr, iran, iraq, syria, jordan, turkey, israel, egypt, and cyprus. it inhabits caves, ruins, and burrows of rodents and small mammals. in the northern countries, o. tholozani also lives in houses and cowsheds. in israel, ...200919489923
postexposure treatment with doxycycline for the prevention of tick-borne relapsing fever.tick-borne relapsing fever (tbrf) is an acute febrile illness. in israel, tbrf is caused by borrelia persica and is transmitted by ornithodoros tholozani ticks. we examined the safety and efficacy of postexposure treatment to prevent tbrf.200616837678
detection of relapsing fever in human blood samples from israel using pcr targeting the glycerophosphodiester phosphodiesterase (glpq) gene.relapsing fever caused by borrelia persica is an acute tick-borne disease infecting people in the middle east. a pcr test targeting the glycerophosphodiester phosphodiesterase (glpq) gene was used to detect infection in the blood of suspected relapsing fever patients. the assay detected infection in all 19 patients from israel who were spirochetemic by blood smear examination and in two additional patients with clinical relapsing fever who were negative by smear examination. patients were positi ...200616729949
purification of periplasmic flagellar antigen from borrelia microtti.borrelia microtti and borrelia persica are 2 iranian strains of borrelia found in western asia and responsible for relapsing fever. the outer surface antigens of borrelia undergo variations which are responsible for the relapsing phenomenon. the fixed flagellar antigen is required for diagnosis as the variant antigens cannot be used in serological methods of diagnosis. the fixed flagellar antigen was purified for the first time from the iranian strain of borrelia microtti using detergent treatme ...200212064689
[joseph désiré tholozan and the persian relapsing fever].in the year 1879, tholozan seems to have been convinced of the danger caused by the bites of ornithodores in persia, as a result of very careful observations of sick persons suffering from iranian relapsing fever due to borrelia persica. among the ticks collected by him and sent to entomologists in france was the true vector, named argas (presently ornithodoros) tholozani by laboulbene and megnin. tholozan's contribution to our knowledge on persian relapsing fever is really important. he was one ...199811625357
[a great franco-mauritian epidemiologist: joseph désiré tholozan (1820-18970].born in 1820 from french parents in diego garcia, an islet then linked to mauritius where he started in port-louis his school years, joseph désiré tholozan was an original personality. he undertook medical studies in france (m. d. thesis, paris, 1843) after having joined the military health service (1841) as a surgeon serving in various garrisons in the country and later at the hospital of the valde-grâce in paris (1849). successful at the "agrégation" of medicine in 1853, he later participated ...19989559181
phylogenesis of relapsing fever borrelia spp.the phylogenetic relationships of 20 relapsing fever (rf) borrelia spp. were estimated on the basis of the sequences of rrs genes. complete sequences were aligned and compared with previously published sequences, and the similarity values were found to be 97.7 to 99.9%. phylogenetic trees were constructed by using the three neighbor-joining, maximum-parsimony, and maximum-likelihood methods. the results of the comparative phylogenetic analysis divided the rf borrelia spp. into three major cluste ...19968863409
aseptic meningitis and adult respiratory distress syndrome caused by borrelia persica.the occurrence of some of the clinical complications of tickborne relapsing fever varies with borrelia species. for example, adult respiratory distress syndrome (ards), a newly reported complication, was described so far only with b. hermsii infection.201222782695
culture of borrelia persica and its flagellar antigen in vitro.borrelia persica is a strain seen only in the middle east and responsible for relapsing fever. these spirochetes are notable for multiphasic antigenic variation of polymorphic outer membrane lipoproteins, a phenomenon responsible for immune evasion. diagnosis of the disease is a problem and requires a fixed antigen like the flagellar antigen. in vitro culture of b. persica was carried out for the first time and flagellar antigen was purified from culture. 10% sds was added to the mixture to diss ...201424783801
borrelia persica: in vitro cultivation and characterization via conventional pcr and multilocus sequence analysis of two strains isolated from a cat and ticks from israel.borrelia persica, one of the pathogenic agents of tick-borne relapsing fever, is transmitted by the soft tick ornithodoros tholozani. it causes infections in humans as well as in animals. in this study, we developed a medium, termed pettenkofer/lmu bp, for reliable in vitro cultivation. cell densities up to 5.2×10(7) viable cells/ml were achieved over at least 40 passages. the cultivable b. persica strain isolated from a cat was further analyzed by amplification of the flab gene using convention ...201526169028
a case of canine borreliosis in iran caused by borrelia persica.tick-borne relapsing fever is an endemic disease in iran, with most cases attributed to infection by borrelia persica, which is transmitted by ornithodoros tholozani soft ticks. here, we report spirochetemia in blood of a puppy residing in tehran, iran. the causative species was identified by use of highly discriminative igs sequencing; the 489 bp igs sequence obtained in our study showed 99% identity (100% coverage) when compared with b. persica sequences derived from clinical cases or from o. ...201626776536
tickborne relapsing fever in southern iran, 2011-2013. 025988268
borrelia persica infection in immunocompetent mice--a new tool to study the infection kinetics in vivo.borrelia persica, a bacterium transmitted by the soft tick ornithodoros tholozani, causes tick-borne relapsing fever in humans in the middle east, central asia and the indian peninsula. immunocompetent c3h/heouj mice were infected intradermally with b. persica at varying doses: 1 x 10(6), 1 x 10(4), 1 x 10(2) and 4 x 10(0) spirochetes/mouse. subsequently, blood samples were collected and screened for the presence of b. persica dna. spirochetes were detected in all mice infected with 1 x 10(6), 1 ...201626890814
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