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effects of three environmental variables on sulfate uptake by aerobic bacteria.the effects of various concentrations of sulfate, organic sulfur, and organic carbon on sulfate uptake by aerobic bacteria were studied using pure cultures growing in a defined medium. cultures of pseudomonas fluorescens and corynebacterium striatum took up sulfate faster when young, but sulfate uptake by serratia marcescens was faster in older cultures. organic sulfur was found to decrease sulfate uptake, but at concentrations somewhat higher than occurs in most natural freshwater ecosystems. l ...1975813579
characterization of antibiotic-resistant corynebacterium striatum strains.antibiotic-resistant corynebacterium strains were isolated from 14 harborview and one veterans administration hospital patients in seattle during the period 1987-90. these clindamycin-erythromycin resistant strains were shown to hybridize with the ermcd gene, which was cloned from a corynebacterium diphtheriae plasmid and encodes for a rrna methylase. thirteen of these strains also hybridized with the tetm gene probes, and were tetracycline resistant. the ermcd gene could be transferred, by conj ...19921490919
high-performance liquid chromatography of corynomycolic acids as a tool in identification of corynebacterium species and related organisms.a high-performance liquid chromatography (hplc) study of 307 strains of corynebacterium species and related taxa revealed that strains classified as "corynebacterium aquaticum"; "corynebacterium asperum"; and centers for disease control (cdc) groups 1, 2, a-3, a-4, a-5, b-1, b-3, e, f-2, and i-2 as well as some unidentified coryneforms do not contain any corynomycolic acids; therefore, they should not be included in the genus corynebacterium. such an hplc method of identification permitted the c ...19921624556
native valve endocarditis caused by an organism resembling corynebacterium striatum.an organism resembling corynebacterium striatum was isolated from the blood of a patient with acute aortic valvular insufficiency and no history of valvular heart disease. at autopsy, histopathologic examination of the aortic valve revealed pleomorphic gram-positive bacilli and destruction of valvular tissue. our isolate differed from other nondiphtherial corynebacteria, including the type strain of c. striatum (atcc 6940), in its ability to reduce nitrite. nitrite reduction may be useful for di ...19902298880
septicaemia in a granulocytopenic patient caused by corynebacterium striatum.a 64 year old woman with metastatic endometrial carcinoma was admitted to the hospital after three grand mal seizures. blood cultures yielded corynebacterium striatum. the patient responded to parenteral ampicillin therapy. this is believed to be the first case of sepsis caused by this organism.19892594603
corynebacterium striatum: an unusual organism isolated in pure culture from sputum. 19863794367
pleuropulmonary infection due to corynebacterium striatum.corynebacterium striatum, a saprophytic diphtheroid in man, caused a pleuropulmonary infection in a patient with chronic lymphocytic leukaemia. this organism has not previously been described as a cause of human disease.19807426360
phenotypic characteristics of 31 strains of corynebacterium striatum isolated from clinical samples.during a 34-month period (january 1991 to october 1993), 31 corynebacterium striatum stains recovered from clinical samples from 24 patients were characterized. twenty (64%) strains were isolated from wound exudates, 5 (16%) were isolated from bronchial aspirates, 2 (7%) were isolated from urine, 2 (7%) were isolated from endotracheal tubes, 1 (3%) was isolated from a catheter, and 1 (3%) was isolated from empyema. the organisms were identified by conventional culture and phenotypic characteriza ...19957494046
comparison of e-test with broth microdilution and disk diffusion for susceptibility testing of coryneform bacteria.the susceptibilities of 135 coryneform bacteria isolated from clinical samples to ampicillin (amp), cephalothin (cr), cefoxitin (fox), cefotaxime (ctx), erythromycin (e), ciprofloxacin (cip), tetracycline (te), amikacin (ak), vancomycin (va), and rifampin (r) were determined by disk diffusion, broth microdilution, and the e-test. the following species (number of isolates in parentheses) were included: corynebacterium urealyticum (30), corynebacterium minutissimum (20), coryneform cdc group anf-1 ...19957615748
capd peritonitis due to corynebacterium striatum. 19957734577
fatal pulmonary infection caused by corynebacterium striatum. 19947803665
native valve endocarditis due to corynebacterium striatum: case report and review.we report the first known case of native valve endocarditis due to corynebacterium striatum and review 51 previously reported cases of native valve endocarditis due to non-diphtheriae corynebacteria. of the 52 patients with corynebacterial endocarditis, 11 (21%) had no predisposing conditions and 27 (52%) had structural heart disease; endocarditis in the remaining 14 patients (27%) was associated with noncardiac predisposing factors including injection drug use, chronic hemodialysis, vasculitis, ...19947888534
molecular evidence of person-to-person transmission of a pigmented strain of corynebacterium striatum in intensive care units.during a 14-month period, a unique strain of corynebacterium striatum that produces a diffusible brown pigment was isolated from purulent sputa of nine patients and from nonrespiratory sites of two additional patients. seven nonpigmented clinical isolates from the same period and three reference strains of c. striatum were compared with the brown isolates. most patients had multiple sputum cultures with no coryneforms before the brown strain emerged, suggesting that the organism was hospital acq ...19947907342
corynebacterium striatum bacteremia in a patient with aids. 19948086529
comparative in vitro activities of new quinolones against coryneform bacteria.the in vitro activities of eight quinolones against 115 coryneform bacteria (20 corynebacterium jeikeium, 15 corynebacterium minutissimum, 15 corynebacterium striatum, 25 corynebacterium urealyticum, 10 corynebacterium xerosis, 10 corynebacterium group anf-1, 10 corynebacterium group 12, and 10 listeria monocytogenes) were determined. the mics of ciprofloxacin, ofloxacin, and sparfloxacin for 90% of c. jeikeium, c. urealyticum, and c. xerosis isolates tested were > 16 micrograms/ml. those of bay ...19948092851
isolation of corynebacterium striatum from three hospital patients. 19948168560
pursuit of the corynebacterium striatum type strain.the description of corynebacterium striatum (chester 1901) eberson 1918al in bergey's manual of systematic bacteriology has many inconsistencies with the identification scheme from the centers for disease control and prevention. we have studied the four c. striatum reference strains available from the american type culture collection and the national collection of type cultures and found that they fit the centers for disease control and prevention description of this species. however, it appears ...19938240967
evidence of multiple taxa within commercially available reference strains of corynebacterium xerosis.attempts to identify coryneform isolates resembling corynebacterium xerosis can lead clinical microbiologists to identification schemes with conflicting descriptions which result in confusing c. xerosis with corynebacterium striatum. for the present study we purchased all available american type culture collection and national collection of type cultures reference cultures of c. xerosis (n = 10) and c. striatum (n = 4) and analyzed them as follows: (i) analysis of biochemical reactions in conven ...19938349754
corynebacterium striatum: a diphtheroid with pathogenic potential.although nondiphtherial corynebacteria are ubiquitous in nature and commonly colonize the skin and mucous membranes of humans, they rarely account for clinical infection. corynebacterium striatum has rarely been reported to be a pathogen, causing pleuropulmonary infections and bacteremia in only immunocompromised or anatomically altered patients. we noted c. striatum to be the infecting pathogen or copathogen in six patients. to our knowledge, this report describes the first cases of c. striatum ...19938353242
comparative chemotaxonomic studies of mycolic acid-free coryneform bacteria of human origin.forty-two clinical isolates were classified as corynebacterium minutissimum, corynebacterium striatum, and corynebacterium cdc group i by the api coryne system. the chemotaxonomic characteristics of the isolates were determined by thin-layer chromatographic analysis. twenty-six isolates were found to have a type iv cell wall (meso-di-aminopimelic acid arabinose, galactose) but did not contain mycolic acids. these 26 isolates shared chemotaxonomic characteristics with those of mycolic acid-free r ...19938370733
corynebacterium striatum: a clinically significant isolate from sputum in chronic obstructive airways disease. 19938505572
corynebacterium striatum: an undescribed agent of pacemaker-related endocarditis. 19968852985
patient-to-patient spread of a single strain of corynebacterium striatum causing infections in a surgical intensive care unit.over a 12-month period, corynebacterium striatum strains were isolated from clinical specimens from 14 patients admitted to a surgical intensive care unit. these isolates were identical by morphology and biotype and displayed the same antibiogram. ten isolates were found to be the sole possible pathogen. these 10 isolates were from six patients, three of whom had signs of infection at the time of positive culture. further typing was performed by random amplification of polymorphic dna analysis, ...19968862563
pulmonary abscess due to corynebacterium striatum.non-diphtheria corynebacteria are normal commensals of the skin and mucous membranes of humans. increasingly, however, these saprophytic organisms are being recognized as pathogens. patients infected with these bacteria typically have an underlying immunosuppressive process and/or an indwelling venous catheter. pleuropulmonary infection with corynebacterium striatum is rare. we present a patient with diabetes mellitus who developed an intrapulmonary abscess due to c. striatum.19968867228
species identities and antimicrobial susceptibilities of corynebacteria isolated from various clinical sources.over a 14-month period, 415 clinical isolates of coryneform gram-positive rods were recovered from various sources and identified to the species level according to recent identification schemes. corynebacterium urealyticum, corynebacterium striatum, corynebacterium amycolatum, and corynebacterium jeikeium predominated, accounting for 63% of all isolates. corynebacterium accolens, corynebacterium striatum, corynebacterium argentoratense, corynebacterium propinquum and corynebacterium pseudodiphth ...19968894575
antimicrobial susceptibility pattern of corynebacterium striatum.the in vitro activities of 16 antimicrobial agents against 86 strains of corynebacterium striatum were evaluated by microdilution using cation-adjusted mueller-hinton broth. mics at which 90% of strains were inhibited were 0.06 microgram/ml for teicoplanin, 1 microgram/ml for vancomycin, 0.03 to 8 micrograms/ml for beta-lactams, 8 micrograms/ml for sparfloxacin, 16 micrograms/ml for ciprofloxacin, 16/304 micrograms/ml for co-trimoxazole (trimethoprim-sulfamethoxazole), 64 micrograms/ml for tetra ...19968913489
corynebacterium striatum meningitis: case report and review of an increasingly important corynebacterium species.for a long time, corynebacteria were considered simple cutaneous contaminants with little potential pathogenicity. corynebacterium striatum is a known saprophytic cutaneous bacterium; however, in the last decade, this organism has been increasingly recognized as a pathogen. it has been mostly implicated in respiratory tract and blood infections. to our knowledge, we report the first case of meningitis due to c. striatum. treatment with intravenous vancomycin resulted in therapeutic success. we a ...19968953066
native valve endocarditis due to corynebacterium striatum: first reported case of medical treatment alone. 19968953092
native valve endocarditis due to corynebacterium striatum. 19969031885
breast abscess due to corynebacterium striatum.corynebacterium striatum, a normal constituent of the skin flora, is rarely pathogenic. previous reports of infection are few, and are mainly confined to immunosuppressed patients or those with indwelling prosthetic devices. we report a case in which the organism caused a recurrent breast abscess in a woman with normal immune function. the only previous reports of corynebacterium striatum mastitis have been in cows.19979409954
cerebrospinal fluid-shunt infection due to corynebacterium striatum. 19979431411
prospective study of catalase-positive coryneform organisms in clinical specimens: identification, clinical relevance, and antibiotic susceptibility.during a 6-month period, all clinical isolates of catalase-positive coryneform organisms, which were isolated during the routine processing of clinical specimens, were characterized in the laboratory of the 1800-bed university hospital of leuven. the distribution of the species in the corynebacteria was: corynebacterium amycolatum 70 (53%), corynebacterium jeikeium 16 (12%), corynebacterium striatum 11 (8%), corynebacterium afermentans 10 (7%), corynebacterium minutissimum 9 (6%), cdc coryneform ...19989488824
diversity of coryneforms found in infections following prosthetic joint insertion and open fractures.in a 5-year period, 73 coryneform isolates from prosthetic joint and open fracture infections in 60 patients treated in a hospital specialized in orthopedic surgery were speciated. the most frequent species were corynebacterium amycolatum, corynebacterium striatum, corynebacterium diphtheriae biotype mitis, and corynebacterium jeikeium. at least 14 isolates were deemed clinically significant as sole agents of infection.19989505178
in vitro susceptibilities of aerobic and facultative non-spore-forming gram-positive bacilli to hmr 3647 (ru 66647) and 14 other antimicrobials.the comparative in vitro activity of the ketolide hmr 3647 (ru 66647) and those of structurally related macrolide-lincosamide-streptogramin compounds (erythromycin, roxithromycin, azithromycin, clarithromycin, josamycin, lincomycin, pristinamycin, and quinupristin-dalfopristin) as well as those of benzylpenicillin, doxycycline, vancomycin, teicoplanin, levofloxacin, and rifapentine against 247 aerobic and facultative non-spore-forming gram-positive bacilli were determined by an agar dilution met ...19989593121
corynebacterium striatum chloramphenicol resistance transposon tn5564: genetic organization and transposition in corynebacterium glutamicum.the clinical isolate corynebacterium striatum m82b (formerly corynebacterium xerosis m82b) carries the 50-kb r-plasmid ptp10 conferring resistance to the antibiotics chloramphenicol, erythromycin, kanamycin, and tetracycline. dna sequence analysis of the chloramphenicol resistance region revealed the presence of the 4155-bp transposable element tn5564. the ends of tn5564 are identical 22-bp inverted repeats flanked by a 6-bp target site duplication. the central region of tn5564 encodes the chlor ...19989735314
[bacteremia by corynebacterium striatum and neutrocytic ascites. presentation of a case and review of the literature].corynebacterium striatum is a gram-positive pleomorphic bacillus that has been regarded as a saprophyte of mucous membranes and skin. there are certain difficulties in identifying the corynebacteria species in the laboratory and it is often necessary to resort to techniques which are not available in all laboratories. over recent years, c. striatum has shown itself to be a potential pathogen generally in weakened or immunodepressed individuals, in relation with intravenous catheters and in inten ...19989780425
septic synovitis and arthritis due to corynebacterium striatum following an accidental scalpel injury. 19989868675
[empyema caused by corynebacterium striatum].we present the case of a patient, male aged 21 years, admitted in our hospital for an empyema. a strain of c. striatum has been isolated from the pus sampled through the drainage tube. the isolate was identified on api coryne gallery (bio mérieux s.a., france) (identity 97.1%). the disk sensitivity test showed sensitivity to penicillin, cefotaxime, amoxicillin-clavulanate and resistance to rifamycin, kanamycin, pefloxacin, ofloxacin, chloramphenicol, erythromycin and lincomycin. the arguments in ...19989932032
the tetab genes of the corynebacterium striatum r-plasmid ptp10 encode an abc transporter and confer tetracycline, oxytetracycline and oxacillin resistance in corynebacterium glutamicum.the tetracycline resistance region of the 50-kb r-plasmid ptp10 from the clinical isolate corynebacterium striatum m82b was analyzed in corynebacterium glutamicum atcc 13032 and confined to a 4.4-kb sphi-sa/i dna fragment. nucleotide sequence analysis revealed two open reading frames, termed teta and tetb, specifying proteins of 513 and 528 amino acids, respectively. the deduced amino acid sequences of tetab displayed similarity to atp-binding cassette transporters including strv and strw of str ...199910220896
[neutrocytic ascites and corynebacterium striatum]. 199910339851
in-vitro activity of levofloxacin, ofloxacin and d-ofloxacin against coryneform bacteria and listeria monocytogenes.the objective of this study was to evaluate the in-vitro activity of levofloxacin, ofloxacin and d-ofloxacin compared with ciprofloxacin, norfloxacin and sparfloxacin against coryneform bacteria and listeria monocytogenes isolated from clinical samples. the following organisms (and number of strains) were studied: corynebacterium jeikeium (20), corynebacterium urealyticum (20), corynebacterium minutissimum (20), corynebacterium striatum (20), corynebacterium amycolatum (30), brevibacterium spp. ...199910404334
microbiological characterization and clinical significance of corynebacterium amycolatum strains.the laboratory records of patients with bacillus isolates identified as corynebacterium xerosis were reviewed in an attempt to establish the clinical significance of the isolates, and the isolated strains were reidentified. of the 22 strains available for reidentification, four were identified as corynebacterium striatum and 18 as corynebacterium amycolatum. forty-one patients were considered to have corynebacterium amycolatum isolates, and in 13 (31.7%) of these patients a genuine clinical infe ...199910482033
the 51,409-bp r-plasmid ptp10 from the multiresistant clinical isolate corynebacterium striatum m82b is composed of dna segments initially identified in soil bacteria and in plant, animal, and human pathogens.the 51,409-bp dna sequence of the multiresistance plasmid ptp10 from the gram-positive opportunistic human pathogen corynebacterium striatum m82b has been determined. fully automated genome interpretation led to the identification of 47 orfs. analysis of the genetic organization of ptp10 suggests that the plasmid is composed of eight dna segments, the boundaries of which are represented by transposons and insertion sequences. the dna segments of ptp10 are highly similar to (1) a plasmid-encoded ...200010732668
corynebacterium simulans sp. nov., a non-lipophilic, fermentative corynebacterium.three coryneform strains isolated from clinical samples were analysed. these strains fitted the biochemical profile of corynebacterium striatum by conventional methods. however, according to recently described identification tests for fermenting corynebacteria, the strains behaved rather like corynebacterium minutissimum. the three isolates could be distinguished from c. minutissimum by a positive nitrate and nitrite reductase test and by not fermenting maltose; from c. striatum by their inabili ...200010826822
[pneumonia casued by corynebacterium striatum in a patient with aids]. 200011075494
the bactericidal activities of hmr 3004, hmr 3647 and erythromycin against gram-positive bacilli and development of resistance.the bactericidal activities of two new ketolides, hmr 3004 and hmr 3647, and the potential to develop resistance to these two antibiotics were studied in gram-positive bacilli. as judged by time-kill kinetics both ketolides were mostly bacteriostatic, being bactericidal against only highly susceptible isolates of corynebacterium striatum (two isolates) and corynebacterium minutissimum (one isolate). spontaneous resistant mutants were detected in seven of 30 strains tested, mainly in rhodococcus ...199911252337
activities of gemifloxacin and five other antimicrobial agents against listeria monocytogenes and coryneform bacteria isolated from clinical samples.the in vitro activities of gemifloxacin, ciprofloxacin, ampicillin, doxycycline, gentamicin, and vancomycin were evaluated against 15 listeria monocytogenes strains and 205 coryneform bacteria isolated from clinical samples. the percentages of strains inhibited by gemifloxacin at 0.5 microg/ml were 100% (l. monocytogenes), 93.3% (brevibacterium spp.), 90% (corynebacterium minutissimum), 42.5% (corynebacterium amycolatum), 20% (corynebacterium striatum), 12.5% (corynebacterium jeikeium), and 10% ...200111451706
vertebral osteomyelitis due to corynebacterium striatum. 200111501553
clinical significance of corynebacterium striatum isolated from human samples.objective: to evaluate the clinical significance of and describe factors associated with corynebacterium striatum infection. methods: a retrospective chart review was performed of the c. striatum isolated in a university hospital from january 1991 to july 1995. c. striatum was identified using conventional methods, the api coryne system and cellular fatty acid profiles. results: in the study period, c. striatum was isolated from clinical samples in 127 patients. in 49 patients, data from clinica ...199711864205
corynebacterium striatum first reported case of prosthetic valve endocarditis.we describe the case of a prosthetic valve endocarditis in a 72-year-old woman. corynebacterium striatum was isolated in the blood samples. this organism has been described in a few cases of native valve endocarditis, but this is the first case reported of prosthetic valve endocarditis.200212099749
an unusual case of infective endocarditis.a rare case of corynebacterium striatum endocarditis on a bioprosthetic aortic valve replacement, treated medically, is reported. the presentation was subacute, and initially endocarditis screening was negative. because of the failure of symptoms to settle further screening was performed which confirmed the organism in several sets of blood cultures. this emphasises the importance of persistent screening for endocarditis if the history raises any suspicion of this potentially serious infection, ...200212151574
coryneform bacteria isolated from blood cultures and their antibiotic susceptibilities.we aimed to determine the types of corynebacteria isolated from the blood of patients at gaziantep university hospital, turkey, and their antibiotic susceptibilities. between february 1999 and june 2001, 3530 blood samples were cultured, of which 915 were found to be positive, and these were further investigated in the bacteriology laboratory. among positive blood cultures, coryneform bacteria were identified in 31 (3.4%) isolates. of these, 16 (51.6%) were corynebacterium jeikeium, six (19.4%) ...200212235925
a specific bacterial aminoacylase cleaves odorant precursors secreted in the human axilla.human axillary odor is known to be formed upon the action of corynebacteria sp. on odorless axilla secretions. the known axilla odor determinant 3-methyl-2-hexenoic acid was identified in hydrolyzed axilla secretions along with a chemically related compound, 3-hydroxy-3-methylhexanoic acid. the natural precursors of both these acids were purified from non-hydrolyzed axilla secretions. from liquid chromatography/mass spectrometry analysis, it appeared that the acids are covalently linked to a glu ...200312468539
activities of abt-773 against listeria monocytogenes and coryneform bacteria of clinical interest.the in vitro activities of abt-773 were evaluated against 15 listeria monocytogenes strains and 196 coryneform bacteria isolated from clinical samples. one hundred percent of the l. monocytogenes strains were inhibited by </=0.015 micro g of abt-773/ml. mics of abt-773 ( micro g/ml) at which 50% of the isolates tested were inhibited (mic(50)s) and mic(90)s for other organisms were 0.125 and 0.5 (corynebacterium amycolatum), 1 and >32 (corynebacterium jeikeium), 0.03 and >32 (corynebacterium minu ...200312654678
report of a case with polymicrobial endocarditis related to multiresistant strains.we present a patient with polymicrobial endocarditis who had been operated on previously for a mycotic aneurysm and was seen at the cardiology clinic because of palpitations related to effort. a transesophageal echocardiogram revealed a 15-mm vegetation on his aortic valve. staphylococcus epidermidis and corynebacterium striatum were isolated from the blood cultures. both strains were multiresistant (susceptible to 3 antibiotics at most) against chemotherapy in vitro. microbiological eradication ...200212673107
multidrug-resistant corynebacterium striatum pneumonia in a heart transplant recipient.corynebacterium striatum is a rare, but likely underreported, cause of serious infections in immunocompromised hosts and generally is susceptible to multiple classes of antimicrobial agents. here we report the first case of c. striatum infection in a solid organ transplant recipient. three years after heart transplantation, a 58-year-old man developed bilateral pneumonia and pulmonary embolism. he did not improve with levofloxacin, piperacillin/tazobactam, and heparin treatment. a homogeneous po ...200312791076
septicaemia due to corynebacterium striatum: molecular confirmation of entry via the skin.septicaemia due to corynebacterium striatum occurs infrequently. a case of c. striatum septicaemia with a known skin focus is reported in a 69-year-old male with ischaemia, refractory anaemia and treated for thyroid cancer. the characterization and typing of blood and cutaneous isolates was carried out using biochemical and dna molecular typing methods to analyse the isolates. this is the first reported case with a documented source.200312808083
corynebacterium striatum peritoneal dialysis catheter exit site infection.regarded as normal flora of the human skin and mucus membranes, non-diphtheria corynebacteria are frequently dismissed as contaminants or harmless colonizers. recently, the pathogenic potential of c. striatum has been realized in immunocompromised patients with indwelling medical devices and previous antibiotic exposure.200314579942
corynebacterium suicordis sp. nov., from pigs.nineteen strains of gram-positive, non-motile, non-spore-forming, catalase-positive, rod-shaped bacteria isolated from pigs were characterized by using biochemical, molecular chemical and molecular genetic methods. two distinct groups of organisms were discerned, based on their colonial morphology, camp (christie-atkins-munch-petersen) reaction and numerical profile by using the api coryne system. the first group (13 strains) gave a doubtful discrimination between corynebacterium striatum and co ...200314657140
isolation of coryneform bacteria from blood cultures of patients at a university hospital in saudi arabia.coryneform bacteria have been increasingly recognized as opportunistic pathogens in recent years. the aim of this study is to identify and determine the antimicrobial susceptibility of coryneform bacteria isolated from blood cultures of patients seen at king khalid university hospital (kkuh), riyadh, kingdom of saudi arabia and review the literature.200415322601
exit-site infections by non-diphtheria corynebacteria in capd.non-diphtheria corynebacteria species cause disease in risk populations such as immunocompromised patients and patients with indwelling medical devices. despite reports of exit-site infection and peritonitis caused by non-diphtheria corynebacteria, these organisms are frequently dismissed as contaminants. during a 10-year observation period, we prospectively identified 8 cases of exit-site/tunnel infections caused by 2 different species of corynebacteria (corynebacterium striatum in 5 and c. jei ...200415490985
impact of manufacturing, irradiation and filtration steps to bacterial contamination of autologous fibrin sealant.preoperative production of autologous fibrin sealant has become a routine procedure during the last years. as a certain percentage of blood products is contaminated with bacteria, contamination of plasma used for the production of fibrin sealant cannot be excluded. especially in the orthopaedic setting, application of contaminated fibrin sealant can cause severe infections.200415536048
corynebacterium striatum endocarditis masquerading as connective tissue disorders. 200415598704
corynebacterium striatum: an underappreciated community and nosocomial pathogen.corynebacterium striatum (cs) is an underappreciated human pathogen that has been associated with serious infections in both immunocompetent and immunocompromised hosts. cs infections tend to be more frequent in males and major infection sites have included blood stream, lung, and central nervous system. most are nosocomially acquired and there is a significant association with medical devices ranging from intravascular catheters to central nervous system drainage devices. empiric therapy with v ...200515845432
relationship between mutations in the gyra gene and quinolone resistance in clinical isolates of corynebacterium striatum and corynebacterium amycolatum.quinolone susceptibility was analyzed in 17 clinical isolates of corynebacterium striatum and 9 strains of corynebacterium amycolatum by the e-test method in mueller-hinton agar plates. the c. striatum atcc 6940 strain was used as a control strain. the amplified quinolone resistance determining regions of the gyra genes of c. amycolatum and c. striatum were characterized. four in vitro quinolone-resistant mutants of c. amycolatum were selected and analyzed. both in vivo and in vitro quinolone-re ...200515855486
successful treatment of corynebacterium striatum endocarditis with daptomycin plus rifampin.to report a case of corynebacterium striatum endocarditis that was treated successfully with daptomycin plus rifampin following an unsuccessful attempt at vancomycin desensitization and failure of linezolid therapy.200516144879
first report of prosthetic mitral valve endocarditis due to corynebacterium striatum: successful medical treatment. case report and literature review.a rare case of prosthetic mitral valve endocarditis due to corynebacterium striatum, treated medically, is reported. while this organism has been described in a few cases of native valve endocarditis, only two cases of prosthetic aortic valve endocarditis have been reported. we herewith report the first case of successful medical treatment of prosthetic mitral valve endocarditis due to c. striatum, emphasizing the complicated clinical course and reviewing the literature regarding diagnosis and t ...200616236359
emergence of multidrug-resistant corynebacterium striatum as a nosocomial pathogen in long-term hospitalized patients with underlying diseases.during a 53-month period (march 1994 to august 1998), 48 corynebacterium striatum isolates recovered from clinical specimens were characterized. the organisms were identified by both phenotypic characteristics and 16s rrna gene sequence analysis. thirty-six (75%) were isolated from sputum/bronchial aspirates, 10 (21%) from wound exudates/pus, 1 (2%) from vaginal discharge, and 1 (2%) from an otorrheic specimen. all 48 patients had been hospitalized for treatment of an underlying disease and had ...200616406181
identification of the emerging skin pathogen corynebacterium amycolatum using pcr-amplification of the essential diviva gene as a target.the actinomycete corynebacterium amycolatum is a saprophytic bacterium usually associated with the human skin, but it is at present considered an emergent pathogen as it is isolated from nosocomial settings from samples of immunosuppressed patients. the conventional method to distinguish c. amycolatum from closely related species is mainly based on phenotypic or chemotaxonomic studies. we developed a molecular method to identify rapidly c. amycolatum based on the use of different primers for amp ...200617147766
a spontaneous joint infection with corynebacterium striatum.corynebacterium striatum is a ubiquitous saprophyte with the potential to cause bacteremia in immunocompromised patients. until now, spontaneous infection of a natural joint has not been reported. when phenotyping failed, gene sequencing was used to identify the species. the isolate demonstrated high-level resistance to most antibiotics.200717151206
identification of odoriferous sulfanylalkanols in human axilla secretions and their formation through cleavage of cysteine precursors by a c-s lyase isolated from axilla bacteria.human axillary odor is known to be formed upon the action of corynebacteria sp. on per se odorless axilla secretions. besides the known odoriferous acids, we report the occurrence in human axilla secretions of four odoriferous sulfanylalkanols, namely 3-sulfanylhexan-1-ol (3), 2-methyl-3-sulfanylbutan-1-ol (4), 3-sulfanylpentan-1-ol (5), and 3-methyl-3-sulfanylhexan-1-ol (6). these compounds have a pungent sweat/kitchen odor, also reminiscent of onions with some fruity connotations, and percepti ...200417191898
molecular diagnosis of native mitral valve endocarditis due to corynebacterium striatum. 200617201210
[evaluation of api coryne system, version 2.0, for diphteroid gram-positive rods identification with clinical relevance].the ability of the api coryne system, version 2.0, to identify 178 strains of gram-positive rods was evaluated. seventy eight isolates belonged to genus corynebacterium and one hundred to related genera, all strains were isolated from clinical samples at the laboratory of bacteriology, hospital de clínicas josé de san martin (uba) between 1995 and 2004. the isolates were identified according to von graevenitz and funke's scheme. one hundred and sixty two out of 178 strains (91%) were correctly i ...200617370571
nosocomial outbreak of corynebacterium striatum infection in patients with chronic obstructive pulmonary disease.we describe an unusual cluster of corynebacterium striatum infections in 21 patients with chronic obstructive pulmonary disease (copd) admitted to a medium-size respiratory unit. eleven isolates from eight patients occurred simultaneously within a month. c. striatum is a potentially pathogenic microorganism with the ability to produce nosocomial infectious outbreaks and respiratory colonization in patients with advanced copd.200717409213
arthritis caused by corynebacterium striatum: spontaneous infection? 200717548460
outbreak of multi-resistant corynebacterium striatum infection in an italian general intensive care unit. 200717719684
infections caused by coryneform bacteria in pediatric oncology patients.invasive infections caused by coryneform bacteria are uncommon but have been reported with increasing frequency in recent decades, especially in immunocompromised persons. because pediatric experience is limited, we examined the epidemiology and clinical characteristics of these infections in children undergoing cancer therapy.200818174873
activity of tigecycline against coryneform bacteria of clinical interest and listeria monocytogenes.the activities of tigecycline and eight other agents were evaluated against 220 coryneform bacteria and 42 listeria monocytogenes isolates. all strains were inhibited by tigecycline at 0.5 mug/ml, except for 11 corynebacterium striatum strains that were inhibited at 1 mug/ml. tigecycline shows good in vitro activity against coryneform bacteria and l. monocytogenes.200818227183
an unusual case of corynebacterium striatum endocarditis and a review of the literature. 200818346922
resistance determinant erm(x) is borne by transposon tn5432 in bifidobacterium thermophilum and bifidobacterium animalis subsp. lactis.the erm(x) gene from erythromycin- and clindamycin-resistant bifidobacterium strains was characterised by polymerase chain reaction and sequence analysis, including flanking regions. results suggest that the resistance determinant was part of transposon tn5432 that has been described in several opportunistic pathogens such as corynebacterium striatum and propionibacterium acnes.200818378122
isolation of a bacterial enzyme releasing axillary malodor and its use as a screening target for novel deodorant formulations.axillary odor is known since 50 years to be formed upon the action of corynebacteria on odorless axilla secretions, but the nature of the bacterial enzymes involved in this process remained a mystery. we identified the known axilla odor determinant 3-methyl-2-hexenoic acid in hydrolyzed axilla secretions along with a new, chemically related compound, 3-hydroxy-3-methyl-hexanoic acid. the natural, odorless precursors of both these acids were purified from non-hydrolyzed fresh axilla secretions. t ...200518492161
multicenter evaluation of the vitek 2 anaerobe and corynebacterium identification card.the new anaerobe and corynebacterium (anc) identification card for vitek 2 was compared with a 16s rrna gene sequencing (16s) reference method for accuracy in the identification of corynebacteria and anaerobic species. testing was performed on a vitek 2 xl system with modified software at three clinical trial laboratories. reproducibility was determined with nine atcc quality control strains that were tested 20 times over a minimum of 10 days at all three sites. a challenge set of 50 well-charac ...200818562580
nosocomial valve endocarditis due to corynebacterium striatum: a case report.abstract: staphylococcus aureus, coagulase-negative staphylococci, and enterococci sp. are the usual pathogens involved in nosocomial bacterial endocarditis. corynebacterium species isolation in blood specimens is usually considered to be a contaminant. we present an interesting case of native mitral valve endocarditis in a 73 year old african american female that was diagnosed days after she was discharged from our institution. the infection was cleared with medical therapy alone.200819077258
clonal multidrug-resistant corynebacterium striatum strains, italy.we assessed the clinical relevance and performed molecular characterization of 36 multidrug-resistant strains of corynebacterium striatum. pulsed-field gel electrophoresis confirmed a single clone, possessing erm(x), teta/b, cmxa/b, and apha1 genes, but few related subclones. this strain is emerging as a pathogen in italy.200919116057
in vitro activity of tigecycline and 10 other antimicrobials against clinical isolates of the genus corynebacterium.we studied the in vitro activity of tigecycline and 10 other commonly used antibiotics against 135 clinical isolates of non-diphtheria corynebacterium spp. using the etest system. tigecycline minimum inhibitory concentrations for 50% and 90% of the organisms (mic(50) and mic(90) values, respectively, in mg/l) were: corynebacterium urealyticum, 0.094 and 0.125; corynebacterium amycolatum, 0.125 and 2; corynebacterium jeikeium, 0.094 and 0.75; corynebacterium coyleae, 0.064 and 0.064; corynebacter ...200919153032
corynebacterium striatum infecting a malignant cutaneous lesion: the emergence of an opportunistic pathogen.we described a case of a 27-year old male patient with skin and soft tissue infection of a neoplastic lesion caused by corynebacterium striatum, an organism which has been rarely described as a human pathogen. identification was confirmed by dna sequencing. successful treatment with penicillin was achieved. the role of the c. striatum as an emerging opportunistic pathogen is discussed.200919390742
corynebacterium striatum--a classic pathogen eluding diagnosis.we report one case of infective endocarditis and two cases of arthritis due to corynebacterium striatum. after reviewing all previously reported cases, we illustrate the clinical features typical of infection, including nosocomial risk factors and prominent embolic phenomena in the cases of endocarditis. our cases underscore the importance of prompt diagnosis when confronted with positive blood and synovial cultures. this ubiquitous organism and common contaminant is a rare yet deadly pathogen.200919393478
international external quality assurance for laboratory diagnosis of diphtheria.the diphtheria surveillance network (dipnet) encompassing national diphtheria reference centers from 25 european countries is a dedicated surveillance network recognized by the european commission. a key dipnet objective is the quality assessment of microbiological procedures for diphtheria across the european union and beyond. a detailed questionnaire on the level of reference laboratory services and an external quality assessment (eqa) panel comprising six simulated throat specimens were sent ...200919828749
[cystitis and haematuria due to corynebacterium striatum. a case report and review].we herewith report the first case of uncomplicated urinary tract infection due to corynebacterium striatum in an ambulatory patient without any other predisponent risk factors. c. striatum is a ubiquitous saprophyte of human skin and mucous membranes, which has been occasionally associated with infection in patients hospitalized or immunocompromised patients with underlying diseases. we conclude that c. striatum should be considered an emerging pathogen in both immunocompetent and immunocompromi ...200919900386
high frequency of macrolide resistance mechanisms in clinical isolates of corynebacterium species.the genus corynebacterium includes a high number of species that are usually isolated from human skin as saprophytes. however, these microorganisms have also been reported as infectious agents in a broad group of patients and have showed broad-spectrum resistance. we studied the susceptibility profiles against macrolides, clindamycin, and streptogramins of 254 clinical strains belonging to the species corynebacterium urealyticum (120), corynebacterium amycolatum (66), corynebacterium jeikeium (1 ...201020624090
surface bacteriology of venous leg ulcers and healing outcome.bacteria can be cultured from all venous leg ulcers (vlus) regardless of healing status, and the significance of a positive swab result in non-clinically infected ulcers is unknown. the aim of this study was to characterise the bacteriological flora of vlus by routine culture to determine whether the data generated had prognostic value.201020671048
corynebacterium striatum as an emerging pathogen. 201020688419
pacemaker lead endocarditis due to multidrug-resistant corynebacterium striatum detected with sonication of the device.corynebacterium striatum is a commensal of human skin and has been recently recognized as an emerging pathogen. a case of nosocomial pacemaker lead endocarditis due to a multidrug-resistant c. striatum strain is described, highlighting the role of sonication as a diagnostic tool in cardiac device infections.201020943861
[recurrent corynebacterium striatum endocarditis, secondary to osteomyelitis]. 201021195570
[corynebacterium striatum pneumonia in an hiv patient.] 201121477896
enteral tube feeding alters the oral indigenous microbiota in elderly adults.enteral tube feeding is widely used to maintain nutrition for elderly adults with eating difficulties, but its long-term use alters the environment of the oral ecosystem. this study characterized the tongue microbiota of tube-fed elderly adults by analyzing the 16s rrna gene. the terminal restriction fragment length polymorphism (t-rflp) profiles of 44 tube-fed subjects were compared with those of 54 subjects fed orally (average age 86.4 -¦ 6.9 years). barcoded pyrosequencing data were also obta ...201121821752
Antibacterial activity of sphingoid bases and fatty acids against gram-positive bacteria and gram-negative bacteria.There is growing evidence that the role of lipids in innate immunity is more important than previously realized. How lipids interact with bacteria to achieve a level of protection, however, is still poorly understood. To begin to address mechanisms of antibacterial activity, we determined minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of lipids common to the skin and oral cavity: sphingoid bases D-sphingosine, phytosphingosine, and dihydrosphingosine, and f ...201122155833
Corynebacterium striatum bacteremia associated with central venous catheter infection.Corynebacterium striatum (C striatum) has been considered a contaminant of blood culture in past decades. Here we report the case of a patient with acute deterioration of chronic renal failure. She received hemodialysis and died from C striatum bacteremia. By using a randomly amplified polymorphic DNA (RAPD) method, we found that an association existed between C striatum from the bloodstream and that from the central venous catheter. We suggest that C striatum could be a pathogen of bloodstream ...201122154992
non-diphtheriae corynebacterium species: an emerging respiratory pathogen.the purpose of the study was to describe the microbiological and clinical features of ten cases of lower respiratory tract infection due to corynebacterium striatum, corynebacterium propinquum and corynebacterium pseudodiphtheriticum. respiratory samples were recovered from hospitalised patients who were diagnosed of pneumonia and exacerbations of chronic respiratory infections. the samples were gram-stained and seeded on conventional bacterial growing media. bacteria were identified by matrix-a ...201223271676
sonication of explanted cardiac implants improves microbial detection in cardiac device infections.the sonication technique has been shown to be a promising tool for microbiological diagnosis of device-related infections. we evaluated the usefulness of the sonication method for pathogen detection in 80 explanted cardiac components collected from 40 patients, and the results were compared with those of conventional cultures. forty subjects undergoing cardiac device removal were studied: 20 had cardiac device infection, and 20 subjects underwent elective generator replacement or revision in the ...201323196364
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