| some chemical constituents of morinda citrifolia. | | 1979 | 461575 |
| screening of indigenous plants for anthelmintic action against human ascaris lumbricoides: part--ii. | alcoholic extracts of the rhizomes of alpinia galanga, andrographis paniculata, bark of cinnamomum zeylanicum, rind of citrus decumana, desmodium triflorum, seeds of hydnocarpus wightiana, rhizomes of kaempfaria galanga, lippia nodiflora, tender leaves of morinda citrifolia, rhizomes of pollia serzogonian, tephrosia purpuria and rhizomes of zingiber zerumbeth showed good in vitro anthelmintic activity against human ascaris lumbricoides. while, the alcoholic extracts of the bark of alibzzia lebbe ... | 1975 | 1158424 |
| [isolation, identification and biosynthesis of anthraquinones in cell suspension cultures of morinda citrifolia (author's transl)]. | | 1975 | 1187870 |
| anthraquinone production by cell suspension cultures of morinda citrifolia. | | 1975 | 1187876 |
| evolution of the transposable element mariner in the drosophila melanogaster species group. | the population biology and molecular evolution of the transposable element mariner has been studied in the eight species of the melanogaster subgroup of the drosophila subgenus sophophora. the element occurs in d. simulans, d. mauritiana, d. sechellia, d. teissieri, and d. yakuba, but is not found in d. melanogaster, d. erecta, or d. orena. sequence comparisons suggest that the mariner element was present in the ancestor of the species subgroup and was lost in some of the lineages. most species ... | 1992 | 1334916 |
| host-plant specialization in the drosophila melanogaster species complex: a physiological, behavioral, and genetical analysis. | drosophila sechellia, endemic to the seychelles, breeds in a single resource, morinda citrifolia, whereas its close sympatric relative, drosophila simulans, is a cosmopolitan generalist breeding in a great variety of resources. the effects of morinda on various fitness traits of these two species, their f1 hybrids, and reciprocal backcrosses were analyzed. morinda fruit is highly toxic to drosophila species, except d. sechellia. the toxicity is expressed in adults, embryos, and larvae. in embryo ... | 1991 | 1900368 |
| analgesic and behavioural effects of morinda citrifolia. | the traditional therapeutic indications for the use of morinda citrifolia l. (rubiaceae) have been investigated. the lyophilised aqueous extract of roots of m. citrifolia was evaluated for analgesic and behavioural effects in mice. the extract did not exhibit any toxic effects but did show a significant, dose-related, central analgesic activity in the writhing and hotplate tests; this effect was confirmed by the antagonistic action of naloxone. furthermore, administration of m. citrifolia extrac ... | 1990 | 1981810 |
| induction of normal phenotypes in ras-transformed cells by damnacanthal from morinda citrifolia. | we have screened tropical plant extracts for substances that induce normal morphology in k-rasts-nrk cells. as a result we isolated an anthraquinone compound, damnacanthal, from the chloroform extract of the root of morinda citrifolia. damnacanthal induced normal morphology and cytoskeletal structure in k-rasts-nrk cells at the permissive temperature, without changing the amount and localization of ras. the effect of damnacanthal was reversible, and the compound had no effect on the morphology o ... | 1993 | 7693328 |
| anticancer activity of morinda citrifolia (noni) on intraperitoneally implanted lewis lung carcinoma in syngeneic mice. | | 1994 | 7984648 |
| genetics of a nonoptimal behavior: oviposition preference of drosophila mauritiana for a toxic resource. | among three sibling species of the d. melanogaster subgroup, two are generalists (d. simulans and d. mauritiana), while the third, d. sechellia, specializes on a single toxic resource, the fruit of morinda citrifolia. d. sechellia, resistant to the toxics, prefers to oviposit on morinda; d. simulans, which is very sensitive, is strongly repelled. d. mauritiana exhibits an aberrant behavior since it prefers to lay its eggs on morinda, where its embryos are killed. oviposition behavior, studied in ... | 1994 | 7993320 |
| genetics of food preference in drosophila sechellia. i. responses to food attractants. | to reveal the genetic mechanism of host selection in a monophagous fruit fly drosophila sechellia, olfactory responses and oviposition preferences of this species were compared with those of closely related polyphagous species, d. simulans and d. melanogaster. adult flies of d. sechellia were strongly attracted to the ripe fruit of morinda citrifolia which is known to be the sole breeding site of this species. they were also attracted to the odor of n-caproic acid which is contained in the ripe ... | 1993 | 8224853 |
| immunomodulation contributes to the anticancer activity of morinda citrifolia (noni) fruit juice. | | 1996 | 8895953 |
| the genetic basis of drosophila sechellia's resistance to a host plant toxin. | unlike its close relatives, drosophila sechellia is resistant to the toxic effects of the fruit of its host plant, morinda citrifolia. using 15 genetic markers, i analyze the genetic basis of d. sechellia's resistance to this fruit's primary toxin, octanoic acid. d. sechellia's resistance is dominant in f1 hybrids between it and its sister species d. simulans. all chromosomes, except the y and the dot fourth, carry genes affecting resistance. the third chromosome has the greatest effect and carr ... | 1998 | 9691045 |
| jamu gendong, a kind of traditional medicine in indonesia: the microbial contamination of its raw materials and endproduct. | an examination on the microbiological quality of seven kinds of jamu gendong (jg) and their raw materials has been conducted according to the requirements of microbial contamination in traditional medicine, issued by the department of health of indonesia in 1986. samples of jg and their raw materials were taken from producers in three districts of surabaya. the samples were subject to the following examinations: total plate count (tpc), mpn coliform, the enumeration of molds and yeasts, the pres ... | 1998 | 10030724 |
| stimulation of ultraviolet-induced apoptosis of human fibroblast uvr-1 cells by tyrosine kinase inhibitors. | damnacanthal is an anthraquinone compound isolated from the root of morinda citrifolia and was reported to have a potent inhibitory activity towards tyrosine kinases such as lck, src, lyn and egf receptor. in the present study, we have examined the effects of damnacanthal on ultraviolet ray-induced apoptosis in ultraviolet-resistant human uvr-1 cells. when the cells were treated with damnacanthal prior to ultraviolet irradiation, dna fragmentation was more pronounced as compared to the case of u ... | 1999 | 10050753 |
| the effects of turbulent jet flows on plant cell suspension cultures | cell suspensions of morinda citrifolia were subjected to turbulent flow conditions in a submerged jet apparatus, to investigate their hydrodynamic shear susceptibility. the suspensions were exposed to repeated, pressure-driven passages through a submerged jet. two nozzles, of 1 mm and 2 mm diameter, were employed. average energy dissipation rates were in the range 10(3)-10(5) w/kg and cumulative energy dissipation in the range 10(5)-10(7) j/m3. system response to the imposed conditions was evalu ... | 1998 | 10099297 |
| an immunomodulatory polysaccharide-rich substance from the fruit juice of morinda citrifolia (noni) with antitumour activity. | the fruit juice of morinda citrifolia (noni) contains a polysaccharide-rich substance (noni-ppt) with antitumour activity in the lewis lung (llc) peritoneal carcinomatosis model. therapeutic administration of noni-ppt significantly enhanced the duration of survival of inbred syngeneic llc tumour bearing mice. it did not exert significant cytotoxic effects in an adapted culture of llc cells, llc1, but could activate peritoneal exudate cells (pec) to impart profound toxicity when co-cultured with ... | 1999 | 10441776 |
| novel trisaccharide fatty acid ester identified from the fruits of morinda citrifolia (noni). | two known glycosides and a novel trisaccharide fatty acid ester were isolated from the n-butanol-soluble fraction of the fruits of morinda citrifolia (noni). structure determination was carried out by spectral techniques such as ms, ir, nmr, and 2d-nmr. the novel trisaccharide fatty acid ester was elucidated as 2, 6-di-o-(beta-d-glucopyranosyl)-1-o-octanoyl-beta-d-glucopyranose. the known compounds were identified as rutin and asperulosidic acid. | 1999 | 10606546 |
| noni juice (morinda citrifolia): hidden potential for hyperkalemia? | we report the case of a man with chronic renal insufficiency who self-medicated with an alternative medicine product known as noni juice (morinda citrifolia). the patient presented to the clinic with hyperkalemia despite claiming adherence to a low-potassium diet. the potassium concentration in noni juice samples was determined and found to be 56.3 meq/l, similar to that in orange juice and tomato juice. herbal remedies and alternative medicine products may be surreptitious sources of potassium ... | 2000 | 10676732 |
| novel glycosides from noni (morinda citrifolia). | three new glycosides were isolated from the fruits of noni (morinda citrifolia). their structures were determined to be 6-o-(beta-d-glucopyranosyl)-1-o-octanoyl-beta-d-glucopyranose (1), 6-o-(beta-d-glucopyranosyl)-1-o-hexanoyl-beta-d-glucopyranose (2), and 3-methylbut-3-enyl 6-o-beta-d-glucopyranosyl-beta-d-glucopyranoside (3) using ms and nmr methods. | 2000 | 10978225 |
| a new unusual iridoid with inhibition of activator protein-1 (ap-1) from the leaves of morinda citrifolia l. | [structure in text] from the leaves of morinda citrifolia, a new unusual iridoid, named citrifolinoside (1), showing significant inhibition of uvb-induced activator protein-1 (ap-1) activity in cell cultures, has been isolated. its structure was elucidated on the basis of detailed high-field 1d and 2d spectral analysis. | 2001 | 11348221 |
| iridoid glycosides from the leaves of morinda citrifolia. | a new iridoid glucoside (1), named citrifolinoside a, was isolated from the leaves of morinda citrifolia along with the known iridoids asperuloside and asperulosidic acid. the structure of 1 was established by interpretation and full assignments of nmr spectroscopic data. | 2001 | 11421748 |
| two novel glycosides from the fruits of morinda citrifolia (noni) inhibit ap-1 transactivation and cell transformation in the mouse epidermal jb6 cell line. | the fruit juice of morinda citrifolia (noni), a plant originally grown in the hawaiian and tahitian islands, has long been used by islanders to treat diseases, including cancer. two novel glycosides, 6-o-(beta-d-glucopyranosyl)-1-o-octanoyl-beta-d-glucopyranose and asperulosidic acid, extracted from the juice of noni fruits, were used to examine their effects on 12-o-tedtradecanoylphorbol-13-acetate (tpa)- and epidermal growth factor (egf)-induced ap-1 transactivation and cell transformation in ... | 2001 | 11479211 |
| flavonol glycosides and novel iridoid glycoside from the leaves of morinda citrifolia. | one new iridoid glycoside and five known flavonol glycosides have been isolated from the leaves of morinda citrifolia. the new iridoid exists as an epimeric mixture in solution. complete assignments of the proton and carbon chemical shifts for the individual epimers were accomplished on the basis of high-resolution 1d and 2d nmr data. their antioxidative activities were measured. all of these compounds showed dpph free radical scavenging activity at the concentration of 30 microm. | 2001 | 11559157 |
| cancer preventive effect of morinda citrifolia (noni). | morinda citrifolia (noni) has been extensively used in folk medicine by polynesians for over 2,000 years. it has been reported to have broad therapeutic effects, including anticancer activity, in both clinical practice and laboratory animal models. the mechanism for these effects remains unknown. the hypothesis that morinda citrifolia possesses a cancer preventive effect at the initiation stage of carcinogenesis was studied. our preliminary data indicated that 10% tahitian noni liquid dietary su ... | 2001 | 11795436 |
| the genetic basis of larval resistance to a host plant toxin in drosophila sechellia. | the larvae of drosophila sechellia are highly resistant to octanoic acid, a toxin found in d. sechellia's host plant, morinda citrifolia. in contrast, close relatives of d. sechellia, d. simulans and d. melanogaster, are not resistant. in a series of interspecific backcrosses, 11 genetic markers were used to map factors affecting egg-to-adult ('larval') resistance in d. sechellia. the third chromosome harbours at least one partially dominant resistance factor. the second chromosome carries at le ... | 2001 | 11865712 |
| cytoplasmic acidification and secondary metabolite production in different plant cell suspensions (a comparative study). | in this study, a correlation is described between low cytoplasmic ph, measured with the fluorescent probes 2[prime],7[prime]-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein (acetoxymethyl ester) and bis- [3-propyl-5-oxoisoxazol-4-yl]pentamethine oxonol, and the production of secondary metabolites for several plant cell-suspension systems. anthraquinone production in morinda citrifolia suspensions is negligible in the presence of 2,4-dichlorophenoxyacetic acid (2,4-d), whereas with naphthalene ... | 1994 | 12232364 |
| antimalarial activity of extracts and alkaloids isolated from six plants used in traditional medicine in mali and sao tome. | methanol and chloroform extracts were prepared from various parts of four plants collected in mali: guiera senegalensis (gmel.) combretaceae, feretia apodanthera (del.) rubiaceae, combretum micranthum (don.) combretaceae, securidaca longepedunculata (fres.) polygalaceae and two plants -collected in sao tome: pycnanthus angolensis (welw.) myristicaceae and morinda citrifolia (benth.) rubiaceae were assessed for their in vitro antimalarial activity and their cytotoxic effects on human monocytes (t ... | 2002 | 12410545 |
| antitubercular constituents from the hexane fraction of morinda citrifolia linn. (rubiaceae). | a crude ethanol extract and hexane fraction from morinda citrifolia linn. (rubiaceae) show antitubercular activity. the major constituents of the hexane fraction are e-phytol, cycloartenol, stigmasterol, beta-sitosterol, campesta-5,7,22-trien-3beta-ol and the ketosteroids stigmasta-4-en-3-one and stigmasta-4-22-dien-3-one. e-phytol, a mixture of the two ketosteroids, and the epidioxysterol derived from campesta-5,7,22-trien-3beta-ol all show pronounced antitubercular activity. | 2002 | 12410555 |
| preliminary investigation of the anti-inflammatory properties of an aqueous extract from morinda citrifolia (noni). | | 2002 | 12434536 |
| morinda citrifolia (noni): a literature review and recent advances in noni research. | morinda citrifolia l (noni) has been used in folk remedies by polynesians for over 2000 years, and is reported to have a broad range of therapeutic effects, including antibacterial, antiviral, antifungal, antitumor, antihelmin, analgesic, hypotensive, anti-inflammatory, and immune enhancing effects. in order to reveal the nutritional and medicinal value of the noni plant, and to summarize scientific evidence that supports the polynesians' claim, a literature review and recent advances in noni re ... | 2002 | 12466051 |
| a cross-cultural study: anti-inflammatory activity of australian and chinese plants. | in this study, in vitro inhibitory effects of 33 ethanol extracts obtained from 24 plant species (representing 11 different families) on cyclooxygenase-1 (cox-1) were evaluated. the plant materials selected for this study have been used in aboriginal medicine in australia and traditional medicine in china for the treatment of various diseases that are considered as inflammation in nature, e.g. asthma, arthritis, rheumatism, fever, edema, infections, snakebite and related inflammatory diseases. a ... | 2003 | 12576199 |
| new unusual iridoids from the leaves of noni (morinda citrifolia l.) show inhibitory effect on ultraviolet b-induced transcriptional activator protein-1 (ap-1) activity. | a novel iridoid dimer in whose structure the two iridoid units are connected by a rare ether group, together with two new unusual iridoids showing significant inhibition of uvb-induced activator protein-1 (ap-1) activity in cell cultures, have been isolated from the leaves of noni (morinda citrifolia l.). their structures were determined on the basis of detailed high-field 1d and 2d spectral analysis. their inhibitory effect on uvb-induced transcriptional activator protein-1 (ap-1) activity are ... | 2003 | 12757717 |
| agrobacterium tumefaciens-mediated transformation of indian mulberry, morus indica cv. k2: a time-phased screening strategy. | an efficient and reproducible protocol for the production of transgenic plants was developed for morus indica cv. k2 by agrobacterium tumefaciens-mediated transformation. the hypocotyls, cotyledon, leaf and leaf callus explants precultured for 5 days on regeneration medium were co-cultivated with a bacterial suspension at 10(9) cells/ml for 3 days in the dark. infectivity of a. tumefaciens strain lba4404 was more than that of strains gv2260 and a281, and among the various plasmids tried, pbi121 ... | 2003 | 12789417 |
| regulation of anthraquinone biosynthesis in cell cultures of morinda citrifolia. | cell cultures of morinda citrifolia l. are capable of accumulating substantial amounts of anthraquinones. chorismate formed by the shikimate pathway is an important precursor of these secondary metabolites. isochorismate synthase (ec 5.4.99.6), the enzyme that channels chorismate into the direction of the anthraquinones, is involved in the regulation of anthraquinone biosynthesis. other enzymes of the shikimate pathway such as deoxy-d-arabino-heptulosonate 7-phosphate synthase (ec 4.1.2.15) and ... | 2003 | 12872482 |
| evaluation of parameters for high efficiency gene transfer via particle bombardment in indian mulberry. | particle bombardment is a popular method of direct gene delivery into cell, tissue and organs since it requires minimum pre- and post-bombardment manipulation. in addition, this technique is much easier and fast to perform with intact tissue/organ and reduces the period of in vitro culture. genetic transformation of mulberry, morus indica cv. k2 was attempted by particle bombardment using hypocotyl, cotyledon, leaf and leaf callus explants. the effect of various physical and biological parameter ... | 2002 | 12974402 |
| [treatment and prevention of hypertension and its cerebral complications by total root extracts of morinda citrifolia]. | | 1955 | 13280670 |
| a study of the root of morinda citrifolia linné. i. | | 1958 | 13525210 |
| studies on morinda citrifolia l. ii. | | 1960 | 13855457 |
| isolation and structure determination of a benzofuran and a bis-nor-isoprenoid from aspergillus niger grown on the water soluble fraction of morinda citrifolia linn. leaves. | the leaves of morinda citrifolia, linn. afforded a new benzofuran and a bis-nor-isoprenoid, blumenol c, hitherto unreported from this source. the structures of these have been elucidated as 5-benzofuran carboxylic acid-6-formyl methyl ester (1) and 4-(3'(r)-hydroxybutyl)-3,5,5, trimethyl-cyclohex-2-en-1-one (2) respectively through spectroscopic studies. the nmr data (including 1d, 2d techniques) and stereochemistry at c-3' of compound 2 is also being reported for the first time. | 2003 | 14526916 |
| from polynesian healers to health food stores: changing perspectives of morinda citrifolia (rubiaceae). | morinda citrifolia l (noni) is one of the most important traditional polynesian medicinal plants. remedies from isolated polynesian cultures, such as that of rotuma, illustrate traditional indications that focus upon leaves, roots, bark, and green fruit, primarily for topical ailments. anecdotally collected hawaiian remedies that employ noni fruit illustrate changing usage patterns with shifts in recent times to preparation of juice made of ripe or decaying fruit. ralph m. heinicke promoted a wi ... | 2002 | 14664736 |
| evolution of the olfactory code in the drosophila melanogaster subgroup. | the drosophila melanogaster subgroup has been the focus of numerous studies about evolution. we address the question of how the olfactory code has evolved among the nine sister species. by using in vivo electrophysiological measurements, so called single-cell recordings, we have established the ligand affinity of a defined subset of olfactory receptor neurons (orns) across all nine species. we show that the olfactory code as relayed by the investigated subset of orns is conserved to a striking d ... | 2003 | 14667348 |
| antitumour potential of a polysaccharide-rich substance from the fruit juice of morinda citrifolia (noni) on sarcoma 180 ascites tumour in mice. | an immunomodulatory polysaccharide-rich substance (noni-ppt) from the fruit juice of morinda citrifolia has been found to possess both prophylactic and therapeutic potentials against the immunomodulator sensitive sarcoma 180 tumour system. the antitumour activity of noni-ppt produced a cure rate of 25%-45% in allogeneic mice and its activity was completely abolished by the concomitant administration of specific inhibitors of macrophages (2-chloroadenosine), t cells (cyclosporine) or natural kill ... | 2003 | 14669249 |
| focussed beam reflectance measurement (fbrm) monitoring of particle size and morphology in suspension cultures of morinda citrifolia and centaurea calcitrapa. | laser light scattering technology, as applied in the lasentec focussed beam reflectance measurement (fbrm) system, was used to characterise two morphologically dissimilar plant cell suspension cultures, morinda citrifolia and centaurea calcitrapa. shake-flask suspensions were analysed in terms of biomass concentration and aggregate size/shape over the course of typical batch growth cycles. for the heavily aggregated c. calcitrapa, biomass levels [from 10-160 g fresh weight (fw) l(-1))] were line ... | 2003 | 14719817 |
| inhibition of angiogenic initiation and disruption of newly established human vascular networks by juice from morinda citrifolia (noni). | noni, the juice of the fruit from the morinda citrifolia plant, has been used for centuries as a medicinal agent. we tested the effects of noni juice in a three-dimensional fibrin clot matrix model using human placental vein and human breast tumor explants as sources for angiogenic vessel development. noni in concentrations of 5% (vol/vol) or greater was highly effective in inhibiting the initiation of new vessel sprouts from placental vein explants, compared with initiation in control explants ... | 2003 | 14739620 |
| how two afrotropical endemics made two cosmopolitan human commensals: the drosophila melanogaster-d. simulans palaeogeographic riddle. | despite countless biogeographic, ecological and molecular data, the origin, age and palaeogeographic trajectory of drosophila melanogaster or d. simulans have remained highly debatable. even the most widely accepted views, like the place and antiquity of the wild-to-domestic behavior shift in d. melanogaster, and which of the two species arose first appear questionable. here, we present a critical review of the conflicting hypotheses, and make testable suggestions. although both species are cosm ... | 2004 | 15088644 |
| growth behavior in plant cell cultures based on emissions detected by a multisensor array. | the use of a multisensor array based on chemical gas sensors to monitor plant cell cultures is described. the multisensor array, also referred to as an electronic nose, consisted of 19 different metal oxide semiconductor sensors and one carbon dioxide sensor. the device was used to continuously monitor the off-gas from two plant cell suspension cultures, morinda citrifolia and nicotiana tabacum, cultivated under batch conditions. by analyzing the multiarray responses using two pattern recognitio ... | 2004 | 15296455 |
| are immune responses pivotal to cancer patient's long term survival? two clinical case-study reports on the effects of morinda citrifolia (noni). | in the state of hawaii, there are abundant claims of benefit from cancer patients' use of the fruit juice of morinda citrifolia (noni). there is no well documented clinical report in peer review journals. the author here studiously examined 2 such claims through interview, review of the medical records and pathology slides. the author concludes that these cases are valuable experiences and hope to stimulate interest in noni research as an important part of adjuvant immunotherapy for cancer | 2004 | 15298088 |
| chemical constituents of morinda citrifolia fruits inhibit copper-induced low-density lipoprotein oxidation. | the oxidative modification of low-density lipoprotein (ldl) plays an important role in the genesis of arteriosclerosis. the present study focused on the effects of the fruits of morinda citrifolia on preventing arteriosclerosis. the meoh extract and chcl(3)-, etoac-, n-buoh-, and h(2)o-soluble phases derived from the fruits of m. citrifolia were evaluated for their inhibitory activity on copper-induced ldl oxidation by the thiobarbituric acid-reactive substances (tbars) method. the meoh extract ... | 2004 | 15366830 |
| genetic analysis of indian mulberry varieties through molecular markers. | india is one of the countries where sericulture is being practiced traditionally. due to the higher economic return and the greater employment potential, attempts are being made to increase the productivity by developing high yielding mulberry varieties. at the present, mysore local, bomaypiasbari, kanva-2, bilidevalaya, kajli, s1, bc(2)59, c776, rfs-175, s-36 and victory-1 are being cultivated extensively in different parts of india for rearing the silkworm bombyx mori l. using 17 random amplif ... | 2004 | 15383066 |
| the evaluation of nitric oxide scavenging activity of certain indian medicinal plants in vitro: a preliminary study. | the plant extracts of 17 commonly used indian medicinal plants were examined for their possible regulatory effect on nitric oxide (no) levels using sodium nitroprusside as an no donor in vitro. most of the plant extracts tested demonstrated direct scavenging of no and exhibited significant activity. the potency of scavenging activity was in the following order: alstonia scholaris > cynodon dactylon > morinda citrifolia > tylophora indica > tectona grandis > aegle marmelos (leaf) > momordica char ... | 2004 | 15383230 |
| pressurized hot water extraction of anthraquinones from the roots of morinda citrifolia. | this study examines pressurized hot water extraction of anthraquinones from dried roots of morinda citrifolia (noni). the effects of various operating conditions such as water temperature (110, 170, and 220 degrees c), and water flow rate (2, 4, and 6 ml min(-1)) on extraction yield and extraction rate were determined. at 220 degrees c, the extraction yield was the highest and was approximately 43.6 mg g(-1). subcritical water extraction at 4 ml min(-1) or higher was found to be able to recover ... | 2004 | 15575725 |
| effects of morinda citrifolia on quality of life and auditory function in postmenopausal women. | | 2004 | 15650461 |
| herbal hepatotoxicity: acute hepatitis caused by a noni preparation (morinda citrifolia). | a 45-year-old patient was sent to our department because of highly elevated transaminases and elevated lactate dehydrogenase. his medical history was unremarkable and he took no medication on regular basis. physical examination did not detect any abnormalities. there was no evidence for viral hepatitis, epstein-barr virus or cytomegalovirus, autoimmune hepatitis, budd-chiari syndrome, haemochromatosis or wilson's disease. during the interview he admitted that for 'prophylactic reasons' he had be ... | 2005 | 15756098 |
| effects of juice from morinda citrifolia (noni) on gastric emptying in male rats. | the effects of juice from morinda citrifolia (noni) on gastric emptying, gastrointestinal transit, and plasma level of cholecystokinin (cck) in rats were studied. male rats were given noni by gavage at levels of 0.25, 1, or 4 ml/kg once per day for one or 7 days. the rats in the control group were given water, while the rats in the experimental group were fasted overnight before measurement of gastrointestinal motility. gastrointestinal motility was assessed in rats 15 min after intragastric ins ... | 2004 | 15803749 |
| chemical constituents of the fruits of morinda citrifolia (noni) and their antioxidant activity. | purification of a n-buoh-soluble partition of the meoh extract of morinda citrifolia (noni) fruits led to the isolation of two new iridoid glucosides, 6alpha-hydroxyadoxoside (1) and 6beta,7beta-epoxy-8-epi-splendoside (2), as well as 17 known compounds, americanin a (3), narcissoside (4), asperuloside, asperulosidic acid, borreriagenin, citrifolinin b epimer a, citrifolinin b epimer b, cytidine, deacetylasperuloside, dehydromethoxygaertneroside, epi-dihydrocornin, d-glucose, d-mannitol, methyl ... | 2005 | 15844957 |
| the genetics of adaptation in drosophila sechellia. | drosophila sechellia is an island endemic of the seychelles. after its geographic isolation on these islands, d. sechellia evolved into a host specialist on the fruit of morinda citrifolia--a fruit often noxious and repulsive to drosophila. specialization on m. citrifolia required the evolution of a suite of adaptations, including resistance to and preference for some of the toxins found in this fruit. several of these adaptive traits have been studied genetically. here, i summarize what is know ... | 2005 | 15881686 |
| hepatotoxicity of noni juice: report of two cases. | noni juice (morinda citrifolia) is an increasingly popular wellness drink claimed to be beneficial for many illnesses. no overt toxicity has been reported to date. we present two cases of novel hepatotoxicity of noni juice. causality of liver injury by noni juice was asses-sed. routine laboratory tests and transjugular or percutaneous liver biopsy were performed. the first patient underwent successful liver transplantation while the second patient recovered spontaneously after cessation of noni ... | 2005 | 16094725 |
| ultrasound-assisted extraction of anthraquinones from roots of morinda citrifolia. | this study investigated the use of ultrasound-assisted extraction (uae) to improve the extraction efficiency of the classical solvent extraction techniques such as maceration and soxhlet extraction to extract anti-oxidant activity compounds, anthraquinones, from the root of morinda citrifolia. the effects of different extraction conditions were determined, i.e., temperature of (25, 45, 60 degrees c), ultrasonic power, solvent types, and compositions of ethanol in ethanol-water mixtures. the resu ... | 2006 | 16325453 |
| new anthraquinone and iridoid from the fruits of morinda citrifolia. | from the fruits of morinda citrifolia l., one new anthraquinone, 5,15-o-dimethylmorindol, together with five known anthraquinones and one new iridoid, morindacin, together with two known iridoids, were isolated. their structures were elucidated by analysis of spectroscopic data. | 2005 | 16327199 |
| an anthraquinone with potent quinone reductase-inducing activity and other constituents of the fruits of morinda citrifolia (noni). | morinda citrifolia, commonly known as noni, has a long history of utilization throughout much of tropical polynesia and is considered to be the second most important medicinal plant in the hawaiian islands. recently, the use of noni as a dietary supplement in the united states has greatly increased. bioassay-guided fractionation of a dichloromethane-soluble partition of a meoh extract of noni fruits has led to the isolation of an extremely potent quinone reductase inducer, 2-methoxy-1,3,6-trihyd ... | 2005 | 16378361 |
| induction of extracellular matrix synthesis in normal human fibroblasts by anthraquinone isolated from morinda citrifolia (noni) fruit. | in previous studies we found that morinda citrifolia (noni) fruit extract up-regulated biosynthesis of type i collagen and glycosaminoglycans in primary cultures of normal human fibroblasts. the objective of this study was to identify the active ingredients in noni fruit extract. an active single compound having a type i collagen-stimulating effect was isolated and identified as 1,4-dihydroxy-2-methoxy-7-methylanthraquinone by nuclear magnetic resonance, infrared, and mass analysis. it was revea ... | 2005 | 16379572 |
| tumor cell-selective antiproliferative effect of the extract from morinda citrifolia fruits. | the methanol extract from morinda citrifolia fruits was tested for cytotoxicity activity on the mtt assay. the appearance of cytotoxic changes after exposure to the extract was in a concentration dependent manner. the median lethal concentrations (lc(50)) of the extract in baby hamster kidney (bhk) cells, african green monkey kidney (vero) cells and human laryngeal carcinoma (hep2) cells were found to be 2.5, 3 and 5 mg/ml, respectively. a concentration of 0.1 mg/ml of crude extract exhibited cy ... | 2006 | 16619339 |
| an extract of morinda citrifolia interferes with the serum-induced formation of filamentous structures in candida albicans and inhibits germination of aspergillus nidulans. | an aqueous extract of morinda citrifolia was shown to interfere with the serum-induced morphological conversion of candida albicans from a cellular yeast to a filamentous form in vitro. the conversion of c. albicans from a cellular yeast to a filamentous form in vivo is associated with pathogenicity. no significant effect on growth in serum-free media was seen at the concentrations used to interfere with the morphological change. the same extract also inhibited the germination of apergillus nidu ... | 2006 | 16710899 |
| noni juice is not hepatotoxic. | noni juice (morinda citrifolia) has been approved for use as a safe food within the european union, following a review of safety. since approval, three cases of acute hepatitis in austrian noni juice consumers have been published, where a causal link is suggested between the liver dysfunction and ingestion of anthraquinones from the plant. measurements of liver function in a human clinical safety study of tahitian noni juice, as well as subacute and subchronic animal toxicity tests revealed no e ... | 2006 | 16773722 |
| polysaccharide composition of the fruit juice of morinda citrifolia (noni). | an ethanol-insoluble, high molecular weight fraction was collected from the juice of morinda citrifolia fruit grown in viet nam. the fraction is composed primarily of carbohydrate (67% (w/w)). the polysaccharide fraction consists predominantly of galap (53.6mol%), araf (13.6mol%), galp (17.9mol%) and rhap (9.5mol%). glycosyl linkage analysis suggests the polysaccharide fraction contains mostly the pectic polysaccharides, homogalacturonan (4-galap), rhamnogalacturonan i (4-galap, 2-rhap, 2,4-rhap ... | 2006 | 16777156 |
| hepatitis induced by noni juice from morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg? | a 24-year-old female patient presented to her community hospital with mild elevations of serum transaminase and bilirubin levels. because of multiple sclerosis, she was treated with interferon beta-1a for 6 weeks. after exclusion of viral hepatitis due to hepatitis a-e, interferon beta-1a was withdrawn under the suspicion of drug-induced hepatitis. one week later, she was admitted again to her community hospital with severe icterus. the transaminase and bilirubin levels were highly elevated, and ... | 2006 | 16837801 |
| in vitro screening of five local medicinal plants for antibacterial activity using disc diffusion method. | medicinal plants have many traditional claims including the treatment of ailments of infectious origin. in the evaluation of traditional claims, scientific research is important. the objective of the study was to determine the presence of antibacterial activity in the crude extracts of some of the commonly used medicinal plants in malaysia, andrographis paniculata, vitex negundo, morinda citrifolia, piper sarmentosum, and centella asiatica. in this preliminary investigation, the leaves were used ... | 2005 | 16883283 |
| evaluation of nitric oxide scavenging activity, in vitro and ex vivo, of selected medicinal plants traditionally used in inflammatory diseases. | steroidal and non-steroidal antiinflammatory drugs, despite their various side effects, are in great demand worldwide. alternatively, herbal formulations provide relief to a large percentage of the population suffering from inflammatory diseases. therefore, such practices need to be rationalized through a mechanistic approach. thus, four traditional medicinal plants, namely ventilago madraspatana gaertn., rubia cordifolia linn., lantana camara linn. and morinda citrifolia linn. were selected for ... | 2006 | 16909442 |
| new constituents from noni (morinda citrifolia) fruit juice. | morinda citrifolia l. (rubiaceae), known as noni, has a long history of traditional use in the hawaiian and tahitian islands. more recently, an array of commercial noni fruit juice products are gaining popularity as dietary supplements, with claims of anticancer and immunostimulant activities. the biologically active principles of noni are not fully known. in continuation of work on the isolation of markers from dietary supplements, this paper reports the isolation of three new markers, namely, ... | 2006 | 16910736 |
| noni (morinda citrifolia). | | 2006 | 17022928 |
| noniosides e - h, new trisaccharide fatty acid esters from the fruit of morinda citrifolia (noni). | four new trisaccharide fatty acid esters named noniosides e - h ( 4 - 7) were isolated from the fruit of morinda citrifolia (noni) by a combination of sephadex lh-20, high-speed countercurrent chromatography (hsccc) and semipreparative hplc. their structures were elucidated by high resolution mass spectrometry and 1d- and 2d-nmr as 2,6-di- o-(beta-d-glucopyranosyl)-1-o-hexanoyl-beta-d-glucopyranose (4), 2,6-di-o-(beta-d-glucopyranosyl)-1-o-decanoyl-beta-d-glucopyranose (5), 2-o-(6-o-octanoyl-bet ... | 2006 | 17051459 |
| revision of the structures of citrifolinin a, citrifolinoside, yopaaoside a, yopaaoside b, and morindacin, iridoids from morinda citrifolia l. and morinda coreia ham. | [structure: see text] citrifolin a was revised to dehydromethoxygaertneroside (2). citrifolinoside and yopaaoside a were found to be identical, and their structures were revised to the new structure dehydroepoxymethoxygaertneroside (5). yopaaoside b was revised to citrifolinoside a (9), and morindacin was revised to borreriagenin (11). | 2006 | 17078712 |
| comparative activity of antioxidants from wheat sprouts, morinda citrifolia, fermented papaya and white tea. | hydroalcoholic extracts from wheat sprouts, white tea, morinda citrifolia and fermented papaya were analysed to determine their reducing power and antioxidant activity. the results show that the micromoles of potassium ferricyanide reduced by a quantity of extract corresponding to 1 g of the various dehydrated starting tissues are: 12.91+/-0.83 (wheat sprouts), 10.66+/-1.22 (m. citrifolia), 17.06+/-1.24 (white tea), and 1.05+/-0.09 (fermented papaya). in addition the results show a strong oxygen ... | 2006 | 17127467 |
| new anthraquinones from the stem of morinda citrifolia linn. | studies on the chemical constituents of the stem of morinda citrifolia, linn. have led to the isolation of two new compounds, morindicinone (=2-hydroxy-1,8-dimethoxy-7-methoxymethylanthraquinone, 1) and morindicininone (=4-hydroxymethyl-1,3-dimethoxyanthraquinone, 2), as well as two known constituents, 2-hydroxyanthraquinone (3) and 2-methoxyanthraquinone (4). their structures were elucidated by spectral analysis including 2d-nmr techniques. | 2006 | 17127668 |
| toxicological and analytical investigations of noni (morinda citrifolia) fruit juice. | morinda citrifolia (noni) is known to contain genotoxic anthraquinones in the roots. because of the widespread use of noni juice, the possible genotoxic risk was examined through a battery of short-term tests. noni juice was also chemically analyzed for the possible presence of anthraquinones. noni juice extract in the salmonella microsome assay showed a slight mutagenic effect in strain ta1537, due to the presence of flavonoids. no mutagenicity was observed in the mammalian mutagenicity test wi ... | 2007 | 17227089 |
| new constituents from the leaves of morinda citrifolia. | a new iridoid glycoside, citrifoside (1), and a new anthraquinone, 1,5,15-trimethylmorindol (2), together with 24 known compounds, were isolated from the leaves of morinda citrifolia. the structures of the new compounds were elucidated by spectral data. 1,5,15-trimethylmorindol (2) did not show significant cytotoxic activity by itself but showed cytotoxicity when combined with tumor necrosis factor-related apoptosis-inducing ligand (trail), while citrifoside (1) did not show any activity even wi ... | 2007 | 17268114 |
| generation of reactive oxygen and antioxidant species by hydrodynamically stressed suspensions of morinda citrifolia. | the generation of reactive oxygen species (ros) by plant cell suspension cultures, in response to the imposition of both biotic and abiotic stress, is well-documented. this study investigated the generation of hydrogen peroxide by hydrodynamically stressed cultures of morinda citrifolia, over a 5-h period post-stress imposition. suspensions were exposed to repeated passages through a syringe, under laminar flow conditions, corresponding to cumulative energy dissipation levels of approximately 3- ... | 2007 | 17269681 |
| morinda citrifolia (noni) fruit--phytochemistry, pharmacology, safety. | products derived from noni fruit (morinda citrifolia) have been commercialised in the usa since the 1990s and are increasingly distributed all over the world. a large number of beneficial effects have been claimed for noni. fruit juice of noni has been approved as a novel food by the european commission in 2003. this article reviews current knowledge on the phytochemistry, pharmacology, safety aspects of noni fruit and noni-derived products, and health-related claims and benefits. the knowledge ... | 2007 | 17286240 |
| wound-healing activity of morinda citrifolia fruit juice on diabetes-induced rats. | morinda citrifolia l. is a traditional polynesian medicinal plant which is apparently useful for bowel disorders, skin inflammation, infection, mouth ulcers and wound healing. this study aimed to evaluate the wound-healing activity of morinda citrifolia fruit juice in streptozotocin-induced diabetic rats. | 2007 | 17319624 |
| lipoxygenase inhibitory constituents of the fruits of noni (morinda citrifolia) collected in tahiti. | a phytochemical study of the fruits of noni (morinda citrifolia) collected in tahiti led to the isolation of two new lignans, (+)-3,4,3',4'-tetrahydroxy-9,7'alpha-epoxylignano-7 alpha,9'-lactone (1) and (+)-3,3'-bisdemethyltanegool (2), as well as seven known compounds, (-)-pinoresinol (3), (-)-3,3'-bisdemethylpinoresinol (4), quercetin (5), kaempferol (6), scopoletin (7), isoscopoletin (8), and vanillin. the structures of 1 and 2 were determined by spectroscopic techniques. compounds 3, 6, and ... | 2007 | 17378609 |
| failure of juice or juice extract from the noni plant (morinda citrifolia) to protect rats against oxygen toxicity. | noni juice possesses antioxidant activity and prevents superoxide-mediated tissue injury in laboratory animals. a polysaccharide-rich precipitate of noni juice (noni-ppt) also stimulates tumor necrosis factor (tnf) and interleukin 1 (il-1) in mice. endotoxin (lipopolysaccharide) stimulates tnf and il-1 in rats and protects against superoxide-mediated oxygen toxicity. accordingly, we hypothesized that noni juice, or noni-ppt, would protect rats against pulmonary oxygen toxicity. rats were divided ... | 2007 | 17393917 |
| odorant-binding proteins obp57d and obp57e affect taste perception and host-plant preference in drosophila sechellia. | despite its morphological similarity to the other species in the drosophila melanogaster species complex, d. sechellia has evolved distinct physiological and behavioral adaptations to its host plant morinda citrifolia, commonly known as tahitian noni. the odor of the ripe fruit of m. citrifolia originates from hexanoic and octanoic acid. d. sechellia is attracted to these two fatty acids, whereas the other species in the complex are repelled. here, using interspecies hybrids between d. melanogas ... | 2007 | 17456006 |
| anti-inflammatory and potential cancer chemopreventive constituents of the fruits of morinda citrifolia (noni). | a new anthraquinone, 1,5,15-tri-o-methylmorindol (1), and two new saccharide fatty acid esters, 2-o-(beta-d-glucopyranosyl)-1-o-hexanoyl-beta-d-gluropyranose (4) and 2-o-(beta-d-glucopyranosyl)-1-o-octanoyl-beta-d-gluropyranose (5), have been isolated from a methanol extract of the fruits of morinda citrifolia (noni) along with 10 known compounds, namely, two anthraquinones (2, 3), six saccharide fatty acid esters (6-11), an iridoid glycoside (12), and a flavanol glycoside (13). upon evaluation ... | 2007 | 17480098 |
| [hepatotoxicity caused by a noni (morinda citrifolia) preparation]. | | 2007 | 17516838 |
| noni as an anxiolytic and sedative: a mechanism involving its gamma-aminobutyric acidergic effects. | noni (morinda citrifolia) is increasing in worldwide popularity as a food or dietary supplement with versatile health benefits. the aim of this study was to investigate the effects of noni fruit on anxiety symptoms in vitro. to this end, a competitive gabaa receptor-binding assay was developed. our preliminary study indicates that the methanol crude extract of noni fruit showed significant affinity to the gamma-aminobutyric acid a (gabaa) inhibitory neurotransmitter receptors, and displayed 75% ... | 2007 | 17561385 |
| evaluation of the ergogenic potential of noni juice. | morinda citrifolia (noni) fruit juice is an increasingly popular health food with many reported benefits, such as antioxidant and immunomodulatory properties. traditionally, noni fruit was used by polynesians to combat fatigue. also, clinical studies have revealed that noni juice consumption improves quality of life scores related to physical functioning and energy levels. to further evaluate the ergogenic (antifatigue and endurance promoting) potential of noni juice, aged mice were pretreated o ... | 2007 | 17604369 |
| identification of tlc markers and quantification by hplc-ms of various constituents in noni fruit powder and commercial noni-derived products. | the composition of noni (morinda citrifolia) products has been investigated. tlc profiles of several commercial juices and capsules were compared. 3-methyl-1,3-butanediol was identified as a typical marker in noni juices. the presence of sorbic acid (e200) was detected in one juice declared as additive free. quantitative data have been obtained by hplc-ms. a method for the quantification of characteristic noni constituents, such as iridoid glucosides, scopoletin, rutin, fatty acid glucosides, an ... | 2007 | 17696360 |
| chemical constituents from the stems of morinda citrifolia linn. | studies on the chemical constituents of the stems of morinda citrifolia, linn. have led to the isolation of two new compounds, morindicone (9-hydroxy-2-methoxy-4-methyl-3,10-anthracenedione, 1) and morinthone (4-methoxy-3-heptadecylxanthone, 2), as well as two known constituents, 1-hydroxy-2-methylanthraquinone (3) and 2-hydroxymethylanthraquinone (4). their structures were elucidated by spectral analysis including 2d nmr techniques. | 2007 | 17703727 |
| isolation and structural elucidation of chemical constituents from the fruits of morinda citrifolia linn. | the fruits of morinda citrifolia, linn. afforded a new constituent, morinaphthalenone (1), and three known constituents, scopoletin (2), 1, 3-dimethoxy-anthraquinone (3) and 1, 2-dihydroxy-anthraquinone (4). the structures of these isolated compounds were determined by spectroscopic methods, including 1d- and 2d-nmr (cosy-45, hmqc, hmbc) techniques, as well as by comparison with published values. | 2007 | 17879741 |
| endothelial cytoprotection from oxidized ldl by some crude melanesian plant extracts is not related to their antioxidant capacity. | habitual consumption of some melanesian medicinal and food plants may influence atherosclerosis development via their antioxidant capacity at the endothelial level. areca nut (an; areca catechu), piper inflorescence (pbi; piper betle), betel quid (bq), guava buds (gb; psidium guajava), the leaves (nl), juice (nj), fruit (nf), and root (nr) of noni (morinda citrifolia), the propagules of raw (mbr), and cooked (mbc) mangrove (bruguiera gymnorrhiza) were evaluated for their ability to scavenge the ... | 2007 | 17912700 |
| lignans and anthraquinones from the fruits of morinda citrifolia. | two new anthraquinones, 1,6-dihydroxy-5-methoxy-2-methoxymethylanthraquinone (1) and 1,5,7-trihydroxy-6-methoxy-2-methoxymethylanthraquinone (2), and one new lignan isoamericanoic acid a (3) were isolated from the fruits of morinda citrifolia along with 11 known compounds scopoletin, luteolin, americanin a, americanin d, 3,3'-bisdemethylpinoresinol, p-cresol, p-hydroxybenzoic acid, p-hydroxybenzaldehyde, 4-hydroxy-3-methoxybenzaldehyde, 4-hydroxy-3-methoxycinnamaldehyde, and 2,5-dihydroxy-4-meth ... | 2007 | 17987501 |
| review of the ethnobotany, chemistry, biological activity and safety of the botanical dietary supplement morinda citrifolia (noni). | morinda citrifolia, commonly called noni, has a long history as a medicinal plant and its use as a botanical dietary supplement has grown tremendously in recent years. this has prompted a concomitant increase in research on the phytochemical constituents and biological activity of noni. a relatively large number of scientific publications on noni have been published in recent years, including a number of review articles. the goals of this review are to provide an updated categorization of the ph ... | 2007 | 18053321 |
| the effects of morinda citrifolia l. (noni) on the immune system: its molecular mechanisms of action. | the aim of this study was to investigate the mechanisms involved in the immunomodulatory effects of morinda citrifolia l. (noni) in vitro and in vivo in mice. in vitro, tahitian noni juice (tnj) and noni fruit juice concentrates (nfjc) (1, 5mg/ml) potently activate cannabinoid 2 (cb2), but inhibit cannabinoid 1 (cb1) receptors in a concentration-dependant manner. in vivo, oral administration of tnj ad libitum for 16 days decreased the production of il-4, but increased the production of ifn-gamma ... | 2008 | 18063495 |
| anthraquinones with quinone reductase-inducing activity and benzophenones from morinda citrifolia (noni) roots. | two new benzophenones, morintrifolins a ( 1) and b ( 2), together with 14 known anthraquinones and four other known compounds, were isolated from a chloroform-soluble extract of morinda citrifolia roots. of the isolated compounds, four known anthraquinones, namely, 1,2-dihydroxyanthraquinone ( 3), 1,3-dihydroxy-2-methylanthraquinone ( 4), 2-hydroxy-3-(hydroxymethyl)anthraquinone ( 5), and 1,3,6-trihydroxy-2-methylanthraquinone ( 6), exhibited quinone reductase (qr)- inducing activity in hepa lcl ... | 2007 | 18076142 |
| evaluation of morinda citrifolia as an endodontic irrigant. | the purpose of this study was to compare the in vitro effectiveness of morinda citrifolia juice (mcj) with sodium hypochlorite (naocl) and chlorhexidine gluconate (chx) to remove the smear layer from the canal walls of endodontically instrumented teeth. sixty extracted, single-rooted, mature, permanent, human premolar teeth with a single canal were inoculated with enterococcus faecalis at 37 degrees c in a co2 atmosphere for 30 days. the teeth were randomly allocated to 6 treatment groups; the p ... | 2008 | 18155496 |
| evolution of gene expression in the drosophila olfactory system. | host plant shifts by phytophagous insects play a key role in insect evolution and plant ecology. such shifts often involve major behavioral changes as the insects must acquire an attraction and/or lose the repulsion to the new host plant's odor and taste. the evolution of chemotactic behavior may be due, in part, to gene expression changes in the peripheral sensory system. to test this hypothesis, we compared gene expression in the olfactory organs of drosophila sechellia, a narrow ecological sp ... | 2008 | 18296696 |
| liver protective effects of morinda citrifolia (noni). | this study evaluated the protective effects of noni fruit juice on acute liver injury induced by carbon tetrachloride (ccl(4)) in female sprague-dawley (sd) rats. liver damage (micro-centrilobular necrosis) was observed in animals pretreated with 20% placebo (drinking water) + ccl(4). however, pretreatment with 20% noni juice in drinking water + ccl(4) resulted in markedly decreased hepatotoxic lesions. furthermore, serum alanine aminotransferase and aspartate aminotransferase levels were signif ... | 2008 | 18317933 |
| enhanced bactericidal activity against escherichia coli in calves fed morinda citrifolia (noni) puree. | although adequate colostrum intake and properly used antibiotics can provide much protection for the bovine neonate, increased antibiotic scrutiny and consumer demand for organic products have prompted investigations of natural immunomodulators for enhancing calf health. one plant-based immunomodulator, morinda citrifolia (noni) fruit, is a well-recognized natural product that has a broad range of immunomodulatory effects. | 2008 | 18346148 |
| chemical constituents of morinda citrifolia roots exhibit hypoglycemic effects in streptozotocin-induced diabetic mice. | the hypoglycemic effects of the chemical constituents of morinda citrifolia roots was evaluated in streptozotocin (stz)-induced diabetic mice. the chcl3, etoac, n-buoh and h2o soluble phases of the meoh extract of m. citrifolia roots were administrated orally to stz-induced diabetic mice. only the n-buoh soluble phase showed a significant reduction of the blood glucose levels. from the biologically active n-buoh soluble phase, two iridoids and three anthraquinones were isolated as main constitue ... | 2008 | 18451522 |