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infection and mortality in captive wild-trapped canvasback ducks.fungal, bacterial and malarial infections, as well as malnutrition caused heavy mortality in a group of wild-trapped canvasbacks (aythya valisineria) held in 10 x 3 x 2 m open-water pens. deaths occurred between 21 and 158 days after confinement and were associated with infections of aspergillus fumigatus, escherichia coli, staphylococcus sp., streptococcus sp., klebsiella sp., enterobacter sp., and plasmodium sp. infection and mortality was believed to result from reduced resistance associated ...19761255909
simplified scheme for identification of prompt lactose-fermenting members of the enterobacteriaceae.a brief, simplified scheme involving the spot indole test and colonial morphology was evaluated for genus level identification of prompt lactose-fermenting (plf) members of the enterobacteriaceae. one hundred and ninety-four consecutive, clinically important plf gram-negative rods isolated in a clinical microbiology laboratory were identified by this simplified scheme, as well as by standard biochemical tests, and the api 20e (analytab products, inc., plainview, n.y.) system. in the simplified s ...1976794078
[behavior of some microorganisms cultivated in the presence of irradiated maize starch].the bactericidal effect of water soluble radiolysis products of maize starch on escherichia coli cultures declines when the initial population grows. this toxicity varies with the culture environment and the bacterial species: bacillus subtilis, lactobacillus plantarum, streptococcus faecalis, enterobacter sp. moreover, for the eucaryote cell saccharomyces cerevisiae, wild strain or muting "small colonies", only the generating time is altered by the active parts of radiolysis products. the resul ...1977410543
studies on 4 c stored frozen-reconstituted red blood cells. i. bacterial growth.a knowledge of the growth rates of various organisms at the storage temperature of 4 c in the different suspending media used for red blood cells would aid the extension of the thawed storage time of frozen-reconstituted blood beyond the 24 hours allowed by the food and drug administration. knowing these rates, a prediction could be made that the growth rate would be sufficiently slow and the unit (sterile or minimally contaminated) could be given safely after a longer storage period. the studie ...1977410123
quantitative assessment of bactericidal activities of beta-lactam antibiotics by agar plate method.quantitative bactericidal activities of beta-lactam antibiotics were determined by the agar plate method. broth cultures, of which the colony-forming units were counted before the study, were inoculated on antibiotic-containing agar plates, utilizing a 10(-3), 10(-2), or 10(-1) dilution or undiluted culture plated with each 0.001-ml calibrated loop. these plates were incubated at 37 degrees c overnight, and the minimal drug concentration at which no bacterial growth was observed on the plates wa ...1978102246
antimicrobial susceptibility of clinical isolates of gram-negative bacilli.no one can doubt the increased incidence of gram-negative bacillary infections and the importance of an awareness of this increase. today's hospital, where one finds aggressive surgery, patients with multiple indwelling polyethylene lines and foley catheters, and widespread use of prophylactic antibiotics, serves as a haven for resistant gram-negative bacilli. twenty-five strains of escherichia coli, klebsiella sp, enterobacter sp, pseudomonas sp, indole-negative proteus sp, indole-positive prot ...1975169593
a comparison of the in vitro activity of a new cephalosporin, cefuroxime, and cephalothin against 810 clinical isolates.810 strains of eight species: staphylococcus aureus, staphylococcus epidermidis, streptococcus faecalis, escherichia coli, klebsiella sp, enterobacter sp, proteus mirabilis and proteus vulgaris, were tested by the disc diffusion method against cephalothin and cefuroxime. the activity of the two drugs was comparable to s aureus and s epidermidis, and a little in favour of cefuroxime regarding s faecalis. cefuroxime turned out to be superior to cephalothin against the gram negative rods investigat ...1979398460
bacteriological and protozoal study on domestic water supply in karachi.four hundred and fifty eight water samples collected from domestic tanks and taps and community taps were analysed for bacterial contamination. faecal pollution was more in domestic tanks and taps in mehmoodabad, korangi and least in water collected from community taps of liaquatabad, korangi and mehmoodabad. bacteria isolated were mostly e. coli, enterobacter sp, klebsiella sp. and a. faecalis, while other organisms (except pseudomonas) were found in lower numbers. salmonella para typhi and par ...19911902529
possible beta-lactamase activities detectable in infective clinical specimens.biological beta-lactam antibiotic-inactivating activities were detected in bacteriuria and suppurating pleural fluids. clinical specimens were sterilized with membrane filters and the amounts of ampicillin and/or cephalothin which were being inactivated by 1 ml of each filtrate were determined. in general, filtrates which originally yielded klebsiella sp. tended to show activity against ampicillin; whereas those yielding enterobacter sp. and pseudomonas aeruginosa showed activity against cephalo ...1977413821
[in vitro examination on antibacterial activities of broad-spectrum antibiotics against gram-negative clinical isolates (author's transl)].in vitro studies were undertaken on clinically isolated strains of various bacteria to examine the antibacterial activity of ampicillin (ab-pc), carbenicillin (cb-pc), sulbenicillin (sb-pc) cephalothin (cet), cefazolin (cez) and gentamicin (gm). fifty three % of escherichia coli strains 53.3% of citrobacter sp., 80% of proteus mirabilis, 42.9% of morganella and 80% of bacteroides sp. were susceptible (mic being not higher than 12.5 mug/ml) to ab-pc. the eight other species were not so susceptibl ...19751104913
comparison of the antibacterial activities of sisomicin and gentamicin against gram-negative bacteria.sisomicin was found to be more active on a weight basis than gentamicin against pseudomonas sp., klebsiella sp., and indole-positive proteus. gentamicin was more active than sisomicin against escherichia coli, serratia sp., enterobacter sp., and proteus mirabilis. both antibiotics were very active against methicillin-resistant strains of staphylococcus aureus.19751211927
in vitro activity and pharmacokinetics in patients of cefamandole, a new cephalsoporin antibiotic.cefamandole nafate, a new cephalosporin for parenteral use, was evaluated in vitro against 231 recent clinical isolates and in 12 patients. cefamandole had activity equivalent to cefazolin against staphylococcus aureus, escherichia coli, and klebsiella pneumoniae. cefamandole was more active than cephalothin or cefazolin against proteus mirabilis. both cefamandole and cefazolin were as active as cephalothin against s. aureus, were slightly more active against k. pneumoniae, and were considerably ...19751211920
[neonatal bacterial meningitis: etiological agents in 109 cases during a 10 year period].the etiology of purulent meningitis was investigated in 109 newborn infants admitted in a neonatal intensive care unit throughout a ten year period. bacterial pathogens were isolated from the csf in 57 (52.2%) neonates. there was a predominance of gram-negative bacilli isolated in 38 (34.9%) neonates. gram-positive cocci were isolated from csf in only 12 (11.0%) neonates. microorganisms associated with nosocomial septicemia and meningitis in neonates--klebsiella sp, salmonella sp. enterobacter s ...19921308405
[annual changes of bacteria isolated from urinary tract infections and their susceptibility to new quinolone agents].statistical analyses were conducted on bacterial strains isolated from the urine of patients with urinary tract infections (uti) in the department of urology at aichi medical university from january 1988 through december 1991. the drug sensitivity of the bacterial strains isolated from patients with complicated uti between 1988 and 1991 was analyzed and compared. among the outpatients with uncomplicated uti, a total of 352 strains were isolated. e. coli was isolated the most frequently (90.1%). ...19921336639
epidemiologic aspects of nosocomial infections.in a currently ongoing surveillance of hospital-associated infections in two metropolitan hospitals in oklahoma, the results over a four-month period suggest at least tentative principles of host-agent relationships in hospital-associated infections. within the urinary tract, the site with the highest number of total isolations, escherichia coli and klebsiella pneumoniae were the most common pathogens. by age, the under 5 and over 60 year age groups had the highest number of isolations. staphylo ...19761257828
[a bacteriological study of otitis in dogs (author's transl)].bacteriological examination of 100 cases of otitis in dogs revealed pure cultures of different microorganisms as follows: staphylococcus aureus from 25 animals; escherichia coli from 10; proteus mirabilis from 20; enterobacter sp. from 18 and klepsiella sp. from 7. mixed cultures of proteus mirabilis, pseudomonas aeruginosa and klepsiella sp. were found in 3 animals; staphylococcus aureus and enterobacter sp. in 5; staphylococcus aureus and proteus mirabilis in 4. enterobacter sp. and klepsiella ...19751236059
pharyngeal colonization by gram-negative bacilli in aspiration-prone persons.we compared the prevalence of gram-negative bacilli in the pharyngeal flora of two groups of patients with a known predilection for gram-negative bacillary pneumonia (chronic alcoholics and diabetics), two other groups of aspiration-prone persons with no known predilection for gram-negative bacillary pneumonia (epileptics and narcotic addicts), and normal control subjects. quantitative cultures of saline gargles showed pharyngeal gram-negative bacilli to be significantly (p less than .05) more p ...1978677978
the effects of temperature and growth rate on the proportion of unsaturated fatty acids in bacterial lipids.the effects of temperature and growth rate on the fatty acid composition of the extractable lipids of four mesophilic and three psychotrophic bacteria were examined. two of the mesophiles (escherichia coli and pseudomonas aeruginosa) increased the proportion of unsaturated fatty acids in their lipids with decreasing temperature over their whole growth temperature range. the other mesophiles (enterobacter aerogenes and lactobacillus casei) increased the proportion of unsaturated fatty acids with ...1978624935
identification of a novel aminonucleoside produced by enterobacter sp. as 2'-amino-2'-deoxyguanosine. 19761022341
antimicrobial activity in vitro of cefaclor, a new oral cephalosporin.the antimicrobial activity of cefaclor, a new orally administered cephalosporin derivative, was studied in vitro against a variety of gram-positive and gram-negative clinical isolates. both penicillin-resistant and penicillin-susceptible strains of staphylococcus aureus were susceptible to cefaclor, with mean mics of 1.44 and 0.93 microgram/ml, respectively. however, the mbc for penicillin-resistant s. aureus was higher than that for the penicillin-susceptible strains. all strains of streptococc ...1978624778
comparison of direct and standard antimicrobial disk susceptibility testing for bacteria isolated from blood.to determine the reliability of early antimicrobial susceptibility testing, we compared the results of direct and standard single-disk diffusion methods for 581 positive blood cultures processed routinely by the clinical microbiology laboratory. the direct procedure differed from the standard one only in that the 0.5 mcfarland inoculum was prepared from 1 ml of turbid broth rather than five isolated colonies from a subculture plate. a major discrepancy in results was defined as a change from sus ...1979528681
in vitro activity of ly127935.the activity of ly127935, a beta-lactam antibiotic of novel structure, was studied in vitro against facultative gram-negative bacilli, staphylococcus aureus, and bacteroides fragilis. the strains were recent clinical isolates, many of which were relatively resistant to other antibiotics. ly127935 exhibited striking activity against escherichia coli, klebsiella pneumoniae, enterobacter sp., proteus sp., serratia marcescens, and b. fragilis with median minimum inhibitory concentrations of less tha ...1979507785
antibacterial activity of essential oil components.antibacterial activity of fifteen essential oil components towards food borne staphylococcus sp., micrococcus sp., bacillus sp. and enterobacter sp. was studied by an agar plate technique. cinnamic aldehyde was the most active compound followed by citral, geraniol, eugenol and menthol. at 500 micrograms/ml, cinnamic aldehyde completely inhibited the bacterial growth for more than 30 days at 30 degrees c that was comparable to 200 micrograms/ml of butylated hydroxy anisole (bha). at lower tempera ...19921457292
comparative activity in vitro of ticarcillin, bl-p1654, and carbenicillin.the activity of ticarcillin, bl-p1654, and carbenicillin was compared in vitro using a microtiter tube dilution test in mueller-hinton broth against 50 recent clinical isolates each of staphylococcus aureus, staphylococcus epidermidis, escherichia coli, klebsiella species, enterobacter species, proteus species, and pseudomonas aeruginosa. bactericidal end points were determined using a modified steers replicator. ticarcillin was generally two to four times more active against all organisms teste ...1976984764
effects of mercuric chloride on growth and morphology of selected strains of mercury-resistant bacteria.a survey of the comparative cytological effects of growth in the presence of mercury by a group of mercury-resistant bacterial cultures and a characterization of the process of bacterial adaptation to hg2+ ion was accomplished. mercury resistance was found to be dependent upon the ability to volatilize mercury from the medium and upon the amount of mercury accumulated by the cells. the results indicate that most cultures which adapt to growth in the presence of hgcl2 exhibit extensive morpholo ...19751115499
aerobic and anaerobic microbiology of biliary tract disease.a retrospective analysis of the experiences of two military hospitals over 4 years in the recovery of organisms from biliary tract specimens was done. bacterial growth was obtained in 123 bile specimens. aerobic and facultative bacteria only were present in 59 specimens (48%), aerobic bacteria only were present in 4 specimens (3%), and mixed anaerobic and aerobic or facultative bacteria were present in 60 specimens (49%). of 286 isolates recovered, 216 were aerobic or facultative (1.8 per specim ...19892584384
[gram-negative bacteria isolated from wound infections and their susceptibility to various antibiotics].in this study gram negative pathogens isolated from wound infections and antibiotic susceptibilities of these bacteria were evaluated by using sceptor (bblr) microdilution system. according to the our results, it was observed that enterobacter sp. were found to be major causative agent with the ratio of 22.67%. the isolated gram negative bacteria have been found to be highly resistant to the most of the antibiotics except amikacin.19892487464
combined activitiy of clavulanic acid and ticarcillin against ticarcillin-resistant, gram-negative bacilli.fifty-one clinical isolates of ticarcillin-resistant, gram-negative bacilli were tested for susceptibility to combinations of ticarcillin and clavulanic acid (brl 14151), a potent beta-lactamase inhibitor. minimal inhibitory concentrations (mics) were measured by a microdilution method, and minimal bactericidal concentrations for selected strains were measured by the broth dilution method. ticarcillin mics were >/=128 mug/ml for all and >/=512 mug/ml for 38 (75%) of the strains. thirty-nine stra ...1978308792
enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy.to study the effect of previously administered antibiotics on the antibiotic susceptibility profile of enterobacter, the factors affecting mortality, and the emergence of antibiotic resistance during therapy for enterobacter bacteremia.19911892329
aminoglycosides versus beta-lactams in gram-negative pneumonia.newer beta-lactam antibiotics with high levels of activity against gram-negative aerobic bacilli (including pseudomonas aeruginosa) such as cefoperazone, ceftazidime, imipenem, and aztreonam may be suitable for monotherapy of gram-negative pneumonia. aminoglycoside antibiotics (gentamicin, tobramycin, amikacin are also highly active against these same organisms and have been more extensively used, but are both ototoxic and nephrotoxic. key therapeutic questions are whether beta-lactams can safel ...19911754734
bacteriology, drug stability and exchange of percutaneous delivery systems and antibacterial filters in long-term intrathecal infusion of opioid drugs and bupivacaine in "refractory" pain.to provide a basis for recommendations on the exchange of containers (syringes and cassettes) and antibacterial filters, and for choice of administration device in patients with "refractory" pain treated with long-term percutaneous intrathecal (it) infusions of opioid (morphine or buprenorphine) and bupivacaine mixtures.19921493343
semisynthetic cephalosporins. synthesis and structure-activity relationships of 7-(1-pyrryl)- and 7-(1-indolyl)acetamidocephalosporin derivatives.a series of 1-pyrrole- and 1-indoleacetamido derivatives of 3-heteroaryl-substituted cephalosporins was prepared. the most active compound in the series was 7-[[2-(1-pyrryl)acetyl]amino]-3-[[(1-methyltetrazol-5-yl)thio]-methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6), which showed comparable potency in vitro and in vivo to that of cefazolin, and, in addition, was more potent than cefazolin against enterobacter sp. and providencia stuartii.1978722761
[a two-year prospective survey on nosocomial infections].a two-year randomized prospective survey on nosocomial infections in hospitalized patients of hua shan hospital from 1985 to 1987 was carried out. altogether 1,826 patients were enrolled in the study, the incidence of nosocomial infection being 13.1%. the incidence in dermatology ward was the highest (19.8%), then in order of frequency; medical ward 16.5%, surgical ward 14.8%, ward of neurology 13.7%, ward of neurosurgery 12.7% etc. regarding the location of infection, lower respiratory tract in ...19911650640
ticarcillin/clavulanate in the treatment of severe peritonitis.a prospective study was performed on 50 consecutive patients with secondary peritonitis. all patients received ticarcillin/clavulanate 5.2 g three times daily as initial antibiotic therapy. in 30 patients a primary perforation was found in the gastro-intestinal tract and 20 had post-operative peritonitis. in two thirds of the patients a diffuse peritonitis was found which affected the whole abdomen. thirty-six patients underwent one or two laparotomies and 11 patients had more than three laparot ...19892691475
[clinical evaluation of imipenem/cilastatin sodium in the internal medicine].fifty-two patients with moderate or severe infections associated with internal medicine were treated with imipenem/cilastatin sodium (ipm/cs) and the efficacy and the safety of this drug were evaluated. there were 20 patients with pneumonia, 10 with acute exacerbation of chronic respiratory tract infections, 9 with sepsis, 2 with pyothorax, 3 with intraabdominal infection, 2 with urinary tract infection, 1 with pulmonary abscess, 1 with infective endocarditis, 4 with fever of unknown origin. for ...19911920813
electrical impedance measurements in the reading and monitoring of broth dilution susceptibility tests.electrical impedance changes in the medium were studied during traditional broth dilution tests. tests involved clinical isolates of escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, enterobacter sp., klebsiella, and enterococcus and ten antibiotics. minimal inhibitory concentration (mic) values from overnight visual readings were compared with mic values determined from electrical impedance end points, using inocula of 10(6) organisms per ml. ninety-three percent of the results w ...1977883819
microwave: practical cost-effective method for sterilizing urinary catheters in the home.we used a standard microwave oven to sterilize red rubber catheters used for intermittent self-catheterization. catheters were incubated for sixty minutes in a suspension of microorganisms isolated from the urine of patients with urinary tract infections. for each trial, 6 catheters were removed from their respective suspensions, placed in separate plastic freezer bags, distributed evenly in a microwave oven (avoiding cold spots), and microwaved simultaneously for twelve minutes. a control cathe ...19902107618
bacteriology of infections in a rural tropical area of kenya: isolates and antibiotic susceptibility.no microbial data are available for rural tropical areas. yet most people in africa live in rural areas where the burdens of infectious diseases remain the primary cause for morbidity and mortality. a pilot study was done by culturing midstream urine from patient with dysuria (100 with gram-negative fermentative rods), blood from patients with fuo (55/307 positive) and swabs from patients with infected wounds (29 with staphylococcus aureus). bacteria were identified and susceptibility tests were ...19911756701
[microbiological evaluation of chemical disinfectants for household use].five disinfectants for household use were advertised on television during 1988 and the first half of 1989. the products were tested by a qualitative (use-dilution with 10 carriers, a conventional and simplified, adapted method) and a qualitative, adapted method with a view to evaluating their antimicrobial activity. the active compounds of the products, according to their respective labels were: 1--parachlorophenol (0-benzil) 0.1%; 2--eter 2.4.4' chloro (iii) 2' hydroxiphenylic 0.1%; 3--n-alkyl ...19902120768
cinoxacin: in vitro antibacterial studies of a new synthetic organic acid.cinoxacin (compound 64716) is a synthetic organic acid with antibacterial activity against most aerobic gram-negative bacilli. minimal inhibitory concentrations of cinoxacin (agar-dilution method) were determined for 419 strains. escherichia coli was the most susceptible group of organisms. the majority of klebsiella sp., enterobacter sp., proteus sp., and serratia marcescens were inhibited by 8 mug of cinoxacin per ml. pseudomonas aeruginosa and all gram-positive isolates tested were resistant ...19751094949
evaluation of thiol broth for the culture of salmonella typhi and other bacteria from blood.thiol broth is known to neutralize various antimicrobial agents. positivity of growth of various species of bacteria from blood in thiol broth was reported as similar to that in tryptic soy broth (tsb). as blood cultures are often used for the diagnosis of typhoid fever, and as patients may receive antimicrobial therapy before blood culture, the positivity and rapidity of growth of salmonella typhi in thiol broth were compared to those in tsb. routine blood culture samples from yonsei medical ce ...19902145703
use of potentially infected donor hearts for cardiac transplantation.despite the nationwide shortage of heart donors, more patients, some of whom are critically ill, are being accepted as candidates for transplantation. thus, on occasion, we have liberalized our donor criteria to meet the demand. we have recently transplanted 16 potentially infected donor hearts into critically ill recipients. of these 16 donors, 7 had multiple positive blood cultures as follows: streptococcus pneumoniae (3), staphylococcus aureus (2), klebsiella pneumoniae (1), and enterobacter ...19902166490
in vitro studies of tigemonam: a comparison of the minimum inhibitory and minimum bactericidal concentrations (mic vs mbc).the in vitro activity of tigemonam, a new oral monobactam, was studied with special attention to minimum inhibitory concentrations (mics) and minimum bactericidal concentrations (mbcs). against 250 clinical isolates, it inhibited 100% of escherichia sp., klebsiella sp., serratia sp., citrobacter sp., providencia sp., proteus sp., morganella sp., aeromonas sp., yersinia sp., shigella sp., and haemophilus sp. at 0.5 mg/l or less. with 1 mg/l, 75% of enterobacter sp. were inhibited; however, three ...19892809701
[study on bacterial infection by the investigation of antimicrobial susceptibility of various clinical isolates. iii. comparison of drug susceptibility between the isolates from the materials of out- and in-patients, and among the isolates from the materials of different hospital units].antimicrobial agents susceptibility of 42, 940 strains of clinical isolates (from 1979 to 1986) were investigated and the data were analyzed on the basis of the sources of isolates; materials from in- and out-patients or from the different hospital units. bacteria studied were limited to the species of which isolates were 100 or more during 1979 to 1986. the following results were obtained. i) when the antibiotic susceptibility of the isolates from the out-patient-materials were compared with th ...19892509589
epidemiology of antibiotic resistance in human isolates of enterobacteriaceae in sicily.the authors have studied the antimicrobial susceptibility of 1073 clinical isolates of various genera of enterobacteriaceae (collected during the period july-december 1988) to ampicillin, piperacillin, cefotaxime, ceftazidime, ceftriaxone, aztreonam, imipenem, gentamicin, amikacin, netilmicin, norfloxacin, and ciprofloxacin. antimicrobial susceptibility was determined by bauer-kirby disk diffusion method. of 1073 tested bacteria, 704 (65.6%) produced beta-lactamase detectable by nitrocefin test. ...19902332782
five years of cefotaxime use in a neonatal intensive care unit.in 1983 our antibiotic regimen for suspected neonatal septicemia was changed from amoxicillin-gentamicin to cefotaxime-amoxicillin. during the subsequent 5-year period we studied the effect of this change in regimen on the bacterial flora of the infants in the unit and the occurrence of serious infections. this was done with bacteriologic surveillance and analysis of the positive blood cultures from 1978 through 1987. a change in the relative numbers of isolated pathogens was observed; klebsiell ...19902179846
continuous chitosan hydrolyzate production by immobilized chitosanolytic enzyme from enterobacter sp. g-1.chitosanolytic enzymes from enterobacter sp. g-1 were immobilized on various carriers to continuously hydrolyze chitosan. four different carriers were tested: fe-3901 (strong basic anion exchange resin, ionic binding), glutaraldehyde-treated fe-4612 (weak basic anion exchange resin, cross-linking), chitopearl (chitosan beads), and alginate calcium. glutaraldehyde-treated fe-4612 and chitopearl immobilized more protein than the others. the enzyme immobilized on fe-3901 had the greatest activity. ...19921369055
evaluation of numerical analysis of sds-page of protein patterns for typing enterobacter cloacae.twenty cultures comprising 13 clinical isolates of enterobacter cloacae from two hospitals, the type and another reference stain of e. cloacae and the type strains of four other enterobacter sp. and of escherichia coli, were characterized by one-dimensional sodium dodecyl sulphate-polyacrylamide gel electrophoresis (sds-page) of whole-cell proteins. the protein patterns were highly reproducible and were used as the basis of a numerical analysis which divided the clinical isolates into nine clear ...19892680547
[studies on 145 cases of septicemia in infancy and childhood--especially on septicemic patients with malignant and hematological diseases].clinical and bacteriological data of 145 inpatients with septicemia, treated at the hospital of chiba university school of medicine from 1972 to 1987, were reviewed by dividing them into three stages. (stages i: 1972-76, stage ii: 1978-82, stage iii: 1983-87) patients with underlying diseases have been increasing: 91.8% of the total patients in stage iii. among the patients with underlying diseases, malignant and hematological diseases occupied about 60%, and in the other diseases, congenital he ...19892507684
[in vitro susceptibility to a new antimicrobial agent (imipenem) of pathogens isolated from inpatients at various centers].imipenem is a beta lactam antibiotic, a highly potent new carbapenem with broad antibacterial spectrum. to test the "in vitro" efficacy of this antimicrobial agent in pathogens more frequent in several medical centers in brazil, susceptibility testing with 10 mcg imipenem disks and, or corresponding mic were carried out with 1231 recent isolates of 41 different bacterial species, obtained mainly from hospitalized patients in 5 different medical centers of the cities of s. paulo, rio de janeiro a ...19892617012
[bacterial flora of the oral cavity, fangs and venom of bothrops jararaca: possible source of infection at the site of bite].culture of fang, fang sheath and venom of fifteen healthy freshly captured bothrops jararaca were analyzed. the bacteria most frequently encountered were group d streptococci (12 snakes), enterobacter sp. (6), providencia rettgeri (6), providencia sp. (4), escherichia coli (4), morganella morganii (3) and clostridium sp. (5). the bacteria observed are similar to those found in the abscesses from bothrops bitten patients. since these snake mouth bacteria may be inoculated during the snake bite, b ...19902259834
[frequency of germ isolation from urinary infections in community practice; their sensitivity to 7 antibiotics including a combination of amoxicillin and clavulanic acid. evaluation on 1611 samples].a multicenter study including 10 outpatient private laboratories (hospital laboratories excluded) was carried out in france. 1,611 urines samples from patients with uti were collected during the forth trimester of 1987. the most frequently recovered pathogens were: e. coli (71%), proteus mirabilis (9%), staphylococcus coagulase (6%), klebsiella (6%), enterobacter (2%). other sorts (streptococcus d, proteus sp, pseudomonas aeruginosa, enterobacter sp) were infrequent (less than 1%). the sensitivi ...19892674870
ciprofloxacin in patients with bacteremic infections. the spanish group for the study of ciprofloxacin.the efficacy and safety of ciprofloxacin in the treatment of 68 episodes of bacteremia were studied. patients were treated intravenously (30 cases), orally (13 cases), or with sequential intravenous/oral therapy (25 cases). intravenous doses ranged from 200 to 400 mg per day and oral doses ranged from 1,000 to 1,500 mg per day. according to the criteria of mccabe and jackson, 39 cases had nonfatal and 29 had ultimately fatal underlying diseases. the clinical condition of patients at the start of ...19892589366
efficacy and safety of higher-dose intravenous ciprofloxacin in severe hospital-acquired infections.in an open prospective study, 54 patients in an interdisciplinary, operative, anesthesiologic intensive care unit were treated with intravenous ciprofloxacin for life-threatening infections. secondary nosocomial pneumonias were the predominant infection in most patients. a total of 88 causative pathogens were isolated from 50 patients. the most commonly isolated organism was pseudomonas aeruginosa; serratia marcescens, staphylococcus aureus, and enterobacter sp. were also isolated. pathogens cou ...19892589385
[long-term observations on the etiology and antibiotic resistance in urinary infections (1971-1987)].the activity "in vitro" of six antibiotics (co-trimoxazole, cephaloridine, nitrofurantoin, carbenicillin, nalidixic acid, gentamicin) was tested against four gram negative: e. coli, pseudomonas sp., klebsiella sp. and enterobacter sp. isolated from urine samples from 1971 to 1987, at the istituto di igiene of trieste. the temporal analysis of antibiograms revealed an decrease of the incidence of resistance in the year 1979, 1980 and 1981. in the following years the percentage of resistance showe ...19902152305
in vitro activity of tigemonam against urinary tract pathogens.tigemonam's in vitro activity was compared with that of aztreonam, cefotaxime, gentamicin, and norfloxacin. thirty-two strains of pseudomonas and 960 strains of enterobacteriaceae were studied using the agar dilution method (including escherichia coli, klebsiella pneumoniae, klebsiella oxytoca, enterobacter sp., serratia marcescens, proteus mirabilis, proteus vulgaris, morganella morganii, and salmonella enterica). tigemonam displayed good activity against enterobacteriaceae. minimum inhibitory ...19892809699
osteomyelitis secondary to trauma or infected contiguous soft tissue.nonhematogenous osteomyelitis (nho) occurred in 24 pediatric patients (ages 8 months to 18 years; median, 14 years; 23 male) admitted from 1980 to 1985. predisposing factors included compound fracture (12), deep decubiti (4) and foot puncture (3). infection involved tibia (7), foot bones (6), proximal femur (3) and ulna (2). patients presented with drainage (64%), pain or tenderness (44%) and fever (32%) lasting for 1 to 180 days (median, 10 days). in 24% both white blood cell count and erythroc ...19882893333
[statistical studies on bacteria isolated from urinary tract infections (report 4)].the statistics and drug sensitivity tests of bacterial florae isolated from the urinary tract in 1983 and 1984 were reviewed. of the 2,222 strains isolated from outpatients, 593 (26.7%) were gram positive cocci, 21.4% were e. coli, 11.3% were enterococcus, 10.4% were proteus sp., 10.0% were p. aeruginosa, 5.6% were alcaligenes sp., 4.2% were s. epidermidis and the rest were others. of the 507 strains isolated from hospitalized patients, 107 (33.5%) were gram positive cocci, 20.3% were enterococc ...19873687632
hospital-acquired urinary tract infection.from 16,534 admissions, 60 patients, 4 days to 15 years of age, with one or more hospital-acquired urinary tract infections were identified during a 5-year period by a prospective surveillance system. the patient charts were subsequently reviewed to characterize the population at risk for such infections and to describe the course and consequences of these infections. infections in individual patients ranged from one to greater than 50. the hospital-acquired urinary tract infection rate for the ...19892913550
microbiology of the female genital tract.patients who contract genital tract infections are predominantly young, are otherwise healthy, and generally respond well to treatment for bacterial infections. these infections are most commonly polymicrobial in etiology, with several noteworthy exceptions. often there is an inciting event such as childbirth, surgical intervention, pregnancy termination or intrauterine contraceptive device insertion. with treatment, prognosis for cure is excellent; however, sequelae such as recurrent infections ...19873548376
ceftazidime and cefotaxime--the clinician's choice.a review of two third-generation cephalosporins, ceftazidime and cefotaxime, is presented. ceftazidime, often used as a single agent, has shown greater activity than cefotaxime against pseudomonas aeruginosa and other pseudomonas species, enterobacteriaceae, acinetobacter sp, and enterobacter sp. it has been effective as monotherapy in the treatment of peritonitis, gynecologic infections, chronic bronchitis, and infections in patients with leukemia and granulocytopenia, as has cefotaxime when in ...19892660995
[laboratory and clinical studies on norfloxacin in pediatrics].norfloxacin (nflx, am-715) is a new quinolone antibacterial agent. in the present study, we carried out laboratory and clinical investigations on nflx in the field of pediatrics. the obtained results are summarized as follows. 1. nflx was very active against escherichia coli, salmonella sp., klebsiella sp., enterobacter sp. and pseudomonas aeruginosa among gram-negative rods. antibacterial activities of nflx against gram-positive cocci were lower than those against gram-negative rods but superio ...19902391753
[susceptibility of clinical bacterial isolates to aztreonam].in vitro activities of 7 antimicrobial agents against organisms (474 strains) isolated from patients with various infections in ehime university hospital from may to july 1986 were investigated. summarized results are as follows: 1. aztreonam (azt) showed potent activities against escherichia coli, citrobacter sp., klebsiella pneumoniae, serratia marcescens, proteus sp., pseudomonas aeruginosa and haemophilus influenzae. 2. antimicrobial activities of azt were especially superior against proteus ...19873121888
a morphological study of the action of equine anti-lipopolysaccharide plasma on gram-negative bacteria.three strains of gram-negative bacteria--one each of escherichia coli, klebsiella pneumoniae and enterobacter sp.--were treated with anti-lipopolysaccharide hyperimmune equine plasma (anti-lps) or non-immune control plasma and examined by scanning electronmicroscopy. within a few minutes of treatment with anti-lps, bacteria were agglutinated. evidence of cell membrane destruction was observed shortly thereafter and total cell disintegration and disruption occurred within 1-2 h. in contrast, non- ...19873309324
susceptibility of gentamicin sensitive and resistant gram negative bacilli to ceftazidime.the in-vitro activity of ceftazidime was compared with other third-generation cephalosporins and gentamicin against 409 isolates. ceftazidime was the most active agent against enterobacter sp., proteus mirabilis, serratia sp., proteus sp. and pseudomonas aeruginosa. it was less active against escherichia coli and klebsiella than moxalactam and cefotaxime but more active than cefoperazone. against gentamicin resistant e. coli, klebsiella, enterobacter and p. aeruginosa, ceftazidime was more activ ...19873124067
susceptibility testing with disc diffusion for new cephalosporins: pre-diffusion revisited.the purpose of the present study was to investigate the effect of 20-hour pre-diffusion, i.e. placing the antibiotic-containing discs on the agar for 20 hours prior to inoculation, as compared to direct diffusion, i.e. placing the discs on the agar immediately after inoculation, for the newer 3. generation cephalosporins as represented by ceftazidime and ceftriaxone. regression lines (zone sizes vs. inhibitory concentrations, as measured by plate-dilution) were constructed for three groups of ba ...19863090857
species-related differences in the incidence of gram-negative bacteria isolated from the cloaca of clinically normal psittacine birds.cloacal swabs from 506 clinically normal psittacine birds of 22 species were aerobically cultured for bacteria and yeasts. in 45 (9%) samples, no microbial organisms were recovered. gram-positive bacteria were recovered from 474 (91%) samples. the incidences of gram-negative bacteria and yeasts were: escherichia coli 157 (31%), enterobacter sp. 21 (4%), klebsiella sp. 3 (0.6%), pseudomonas sp. 4 (0.8%), and yeasts 26 (5%). differences were noted in the recovery rate of e. coli among the various ...19883289533
[clinical experience of chemotherapy with cefmetazole for severe infections accompanying malignant hematological disorders].we made an attempt to treat with cefmetazole (cmz) 25 patients who developed severe infectious diseases while suffering with granulocytopenia associated with the treatment of malignant hematological disorders. 1. determination of bacteriological efficacy while 20 strains were isolated and identified from 15 patients, no significant bacteria were detected in 9 patients. isolates obtained were: 5 strains of enterococcus faecalis, 3 strains of haemophilus influenzae, 2 strains of staphylococcus epi ...19892664248
[enterobacter cloacae and e. aerogenes septicemia: emergence of resistant variants (derepressed cephalosporinase) during treatment with third-generation cephalosporins].from three patients hospitalised in intensive care units with enterobacter septicaemia (two cases with e. cloacae, and one with e. aerogenes), cefotaxime therapy, alone or in combination with an aminoglycoside, selected variants (r) with increased resistance to beta-lactam antibiotics. the cross-resistance extended to all the beta-lactam antibiotics tested, penicillins and cephalosporins, including third-generation cephalosporins. the crude extracts of uninduced cultures of r variants showed hig ...19853157961
[laboratory and clinical studies of norfloxacin in respiratory tract infections].norfloxacin (nflx), a new quinolone antibacterial agent, was investigated for its antibacterial activity and clinical efficacy on respiratory tract infections. the results obtained are summarized as follows: 1. antibacterial activities were evaluated against 127 strains of various bacteria isolated from clinical sources. mic80's of this drug were: against staphylococcus aureus and streptococcus pyogenes 1.56 micrograms/ml; haemophilus influenzae 0.05 microgram/ml or less; and klebsiella sp. and ...19883367509
[clinical and bacteriological study of o-demethylfortimicin a sulfate in urinary infection].o-demethyl-fortimicin-a-sulfate (odmf) is a semisynthetic derivative of fortimicin-a with increased in vitro activity especially against pseudomonas aeruginosa. this study was designed to determine the efficacy of odmf in the treatment of uti and to evaluate the in vitro susceptibility of bacteria isolated from the urine of patients to odmf as compared to tobramycin (to), gentamicin (ge) and amikacin (ak). in 28 hospitalized patients with acute uti, odmf (free base) in a dose of 2 to 5 mg/kg was ...19863534728
[the rapid identification of e. coli by the detection of 3 enzymes].232 isolates of gram-negative, oxidase-negative bacteria, isolated from various samples of different animal species, were tested with help of rapidec coli for the production of beta-glucuronidase, beta-galactosidase and indole. the test correctly identified 164 of 175 e. coli strains (sensitivity 93.7%) and correctly indicated that 57 of 57 isolates of the family enterobacteriaceae (7 citrobacter sp., 18 enterobacter sp., 16 klebsiella sp., 10 proteus sp., 2 providencia sp. and 4 salmonella sp.) ...19892497726
in vitro and in vivo antibacterial activity of ky-109, a new orally active cephalosporin.the in vitro and in vivo antimicrobial potencies of ky-109, a pro-drug of ky-087, were compared with those of amoxicillin, cephalexin (cex), and cefaclor (ccl). the following results were obtained. ky-087, which is the active form of ky-109, had broad antimicrobial spectrum against gram-positive and gram-negative organisms, but showed low antimicrobial activity against enterobacter sp., serratia, and pseudomonas sp. the antimicrobial activities of ky-087 against clinically isolated gram-positive ...19883417567
the in vitro activity of the combination of cefotaxime and hre 664.cefotaxime (ctx) and hre 664 (a novel penem antibiotic) possess complementary in vitro properties. differences can be observed in their antibacterial spectra, their beta-lactamase stability and -inhibition, and their affinity to penicillin-binding proteins. these differences suggested that combinations of the cephalosporin and the penem antibiotic would be advantageous and should be studied. the fractional inhibitory concentration values of checkerboard studies confirmed that ctx and hre 664 act ...19873429341
urinary tract infection.over two years, 9892 mid-stream urine samples from patients attending the aga khan university hospital, karachi were cultured. significant bacterial growth was seen in 23.5% samples. further identification of these organisms revealed 40% of e. coli, 16% pseudomonas aeruginosa, 11% klebsiella aerogenes, 5.0% enterobacter sp., 13% proteus sp., 4.0% serratia liquifaciens, 1.0% acinetobacter sp., 3.0% citrobacter sp., 4.0% enterococci, 0.5% staphylococcus aureus. results of sensitivity tests perform ...19892504948
premarket evaluation of ids rapid ss/u system for identification of urine isolates.a total of 170 fresh clinical urine isolates were tested with a premarket configuration of the rapid ss/u system (innovative diagnostic systems, inc., atlanta, ga.), a qualitative micromethod for the identification of selected organisms commonly isolated from urine specimens. results were compared with those obtained with conventional methods of identifying gram-positive isolates and with the automicrobic system (vitek systems, inc., hazelwood, mo.), utilizing gram-negative identification cards ...19873539997
efficacy and safety of cefpirome (hr810).sixty adult patients with suspected systemic bacterial infections were treated with cefpirome 1 g or 2 g twice daily for 5-22 days. forty-seven patients were evaluable for clinical efficacy. diagnoses in evaluable patients were urinary tract infections (20), pneumonia (10), soft tissue infections (17), and bone and joint infections (4); four patients had two infections each. nine patients were bacteraemic and all were cured; the responsible bacteria were escherichia coli (6), streptococcus pneum ...19883204079
[non-pigmented serratia: utility of hydrolysis of tween 80 in its identification].the ability of serratia sp. to hydrolyze tween 80 and the usefulness of this test for differentiating it from other gram negative bacilli was studied, comparing it with the capacity of production of dnasa by the same strains using the o-toluidine blue method. the total number of strains assayed was 88. the sensitivity obtained was 83.9% and specificity 91.3%, with a positive predictive value of 83.9% and a negative predictive value of 91.2%. using this method to differentiate only non-pigmented ...19883175019
[impact of infections on mortality in children with cancer].a study of the role infections play in the death of 29 children with cancer was conducted from 1983 to 1988. an infection was the main cause of death in twelve patients and was associated with hemorrhage in nine. five of the patients were free of infection at the time of their death. the most frequently found etiological agents found in hemocultures taken while still alive were: staphylococcus epidermidis, staphylococcus aureus, streptococcus viridans, salmonella enteritidis, escherichia coli, e ...19892627272
[aerobic and anaerobic bacterial flora of crural ulcers].in a group of 600 patients treated in the metropolitan dermatological hospital in warsaw bacteriological examination were carried out of swabs from the untreated crural ulcers. in 95% of these cultures growth of pathological aerobic organisms was obtained. coagulase-positive staphylococci (st. aureus) and gram-negative bacteria (pseudomonas aeruginosa, proteus vulgaris, enterobacter sp and e. coli) prevailed. in 27% of cases the cultured strains were resistant to the generally available antibiot ...19883268941
differences in antimicrobial susceptibilities of clinical isolates in saudi arabia and the united states.in vitro antimicrobial susceptibilities of 3,530 clinical isolates at king faisal specialist hospital and research center (kfsh), in riyadh, saudi arabia, were compared with those of 11,041 bacterial isolates at two hospitals of comparable size in the united states. the gram-negative bacteria, especially escherichia coli, proteus-morganella group, enterobacter sp, serratia marcescens, and pseudomonas aeruginosa were generally more resistant to ampicillin, carbenicillin, cephalosporin, gentamicin ...19873586042
a comparative study of the sensitivity of bacteria of various origin to ofloxacin.the sensitivity of 6 antimicrobials (chloramphenicol, tetracycline, ampicillin, cephalothin, trimethoprim/sulfamethoxazole and ofloxacin) was tested on 174 bacteria isolated from three sources: 60 from wounds, 84 from urine and 30 from bronchial excretions. hospital-borne bacteria were compared to those of non-hospital origin for their susceptibility. consecutively, pseudomonas aeruginosa (24 strains), escherichia coli (58), klebsiella sp. (13), enterobacter sp. (3), citrobacter sp. (3), enteroc ...19873474082
occurrence of multiple antibiotic resistance and r-plasmids in gram-negative bacteria isolated from faecally contaminated fresh-water streams in hong kong.the bacterial populations of six freshwater streams in populated areas of the hong kong new territories were studied. there is considerable faecal contamination of these streams, with coliform counts as high as 10(5) c.f.u./ml and the contaminating organisms show a high prevalence of antibiotic resistance and multiple resistance. with direct plating of water samples onto antibiotic-containing media, an average of 49% of the gram-negative bacteria were ampicillin-resistant, 3% chloramphenicol-res ...19873595747
[effect of s6472 and cefaclor on bacterial flora in adult human feces].s6472 is a mixture of cefaclor (ccl) granules with gastric-soluble coating and those with enteric-soluble coating at the ratio (in potency) of 4 to 6. with administration of this formulation, a prolonged blood level of ccl is obtained. s6472 and ccl were administered orally to 19 healthy male volunteers between 20 and 27 years of age (mean: 23 years) weighing between 51 and 80 kg (mean: 64.7 kg). four subjects were given 2 capsules and 5 subjects were given 4 capsules each containing 187.5 mg of ...19863702058
brl-36650: in vitro studies and assessment of serum bactericidal activity after single-dose administration in volunteers.ten healthy volunteers received 1 g of brl-36650, a new formamido-penicillin derivative, given by intravenous infusion over 15 min. levels in serum were measured microbiologically 30, 60, and 120 min after the start of the 15-min infusion and were (mean +/- standard deviation) 102.7 +/- 28.4, 59.7 +/- 11.5, and 9.6 +/- 1.9 mg/liter, respectively. a total of 10 strains each of escherichia coli, klebsiella pneumoniae, serratia spp., and enterobacter spp. and 14 strains of pseudomonas aeruginosa we ...19863755314
[effect of cefminox on bacterial flora in human adult feces].cefminox (cmnx), a new cephamycin, was administered by one shot intravenous injection twice daily with a dose of 1,000 mg each time for 5 days to seven healthy male volunteers whose ages ranged from 21 to 28 years (mean: 25 years) and body weights were from 60 to 92 kg mean: 72 kg). the effect of the drug on fecal bacterial flora was investigated and the concentrations of the drug in feces were measured on 5th day before the treatment, on 0, 3rd, and 5th day (the final day of the treatment) duri ...19863761549
preferred sites of digestion of a ribonuclease from enterobacter sp. in the sequence analysis of bacillus stearothermophilus 5s ribonucleic acid. 19734719125
[treatment of urinary infection with cephadroxyl (pharmachem)--microbiological and clinical research].the bacteria isolated from the urine of renal patients were tested for sensitivity towards cephadroxyl (pharmachem) and other beta-lactam antibiotics--altogether 654 examinations were made. it was established that the gram-positive bacteria (excluding the enterococcus) are sensitive towards cephadroxyl. from the gram negative bacteria e. coli, klebsiella sp., enterobacter sp., p. mirabilis, citrobacter sp. showed the greatest sensitivity towards cephadroxyl, while the indole positive proteus wer ...19873433735
enhancing effect on alkalinization of the medium on the activity of erythromycin against gram-negative bacteria.the antibacterial activity of erythromycin was markedly enhanced by alkalinization of the culture medium or urine within the clinical range (ph 6.0 to 8.2). this effect was demonstrated against recent isolates of escherichia coli, klebsiella pneumoniae, enterobacter sp., and pseudomonas aeruginosa, as well as against staphylococcus aureus and streptococcus faecalis. the urine of normal volunteers was made alkaline by ingestion of sodium bicarbonate or acetazolamide (diamox) during administration ...19684970991
biological properties of three 3-heterocyclic-thiomethyl cephalosporin antibiotics.three new cephalosporin antibiotics, prepared by substitution of heterocyclic groups on 7-aminocephalosporanic acid, possess certain desirable chemical or biological properties. all three compounds are active in vitro against a variety of gram-positive and gram-negative bacteria. minimal inhibitory concentrations (mic) of these bactericidal antibiotics were not significantly affected by changes in ph or nacl content of nutrient broth, or by the use of different inoculum sizes. however, agar-dilu ...19725045468
[the rapid identification of escherichia coli using bactident e. coli].165 (93.7%) of 175 e. coli strains isolated from various materials of different animal species were correctly identified as e. coli with help of commercially available bactident e. coli (e. merck, d-6100 darmstadt). further 52 strains of the family of enterobacteriaceae (2x providencia sp., 2x salmonella sp., 7 citrobacter sp., 9 proteus sp., 15 klebsiella sp., 17 enterobacter sp.) were correctly not identified as e. coli by this test. bactident e. coli is a suitable test for rapid identificatio ...19892647078
in vitro studies of semisynthetic alpha-(substituted-ureido) penicillins.the activity of three alpha-(substituted-ureido) penicillins was evaluated in vitro against 599 clinical isolates of gram-negative bacilli, by use of the broth-dilution technique. at a concentration of 12.5 mug or less/ml, bl-p1597 inhibited 90% of isolates of pseudomonas sp., 56% of enterobacter sp., 67% of indole-positive proteus spp., 72% of escherichia coli, and 85% of proteus mirabilis. bl-p1654 had similar activity, whereas bl-p1532 was much less active. at a concentration of 25 mug or les ...19714930281
multicenter clinical trials of cefoperazone in japan.the safety and clinical efficacy of cefoperazone were evaluated at 149 institutions in japan. a total of 979 hospitalized patients were treated with cefoperazone alone for 1,059 infections. in the 984 infections evaluated, there was an overall satisfactory clinical response in 824 (83.7%). cefoperazone was effective in 83.0% of the respiratory tract infections, 84.9% of urinary tract infections, and 89.6% of hepatobiliary tract infections. clinical response was satisfactory in 90% or more of the ...19846394129
[effect of brl 25000 (clavulanic acid-amoxicillin) on bacterial flora in human feces].brl 25000 (187.5 and 375 mg tablets), a formulation of cva-k and ampc in the ratio of 1:2, and ampc (as control drug) were administered to healthy volunteers, aged 20 approximately 28 years and weighing 60 approximately 85 kg (68.8 kg, on average). each drug was administered 3 times a day (after meals) for 5 days and the volunteers were separated into 3 groups of 4 subjects each. the effect on the fecal flora was studied before dosage, during administration (day 3 and 5) and day 3 and 5 after th ...19853847525
synergistic effect of cephalexin with mecillinam.in vitro and in vivo synergistic effects of cephalexin and mecillinam against escherichia coli, klebsiella pneumoniae, enterobacter sp., serratia marcescens and proteus sp. were demonstrated and their action mechanism were also discussed. the growth curve after the exposure of cephalexin and mecillinam at the concentrations at which these antibiotics had no effects when given alone showed a decreased of the turbidity and the presence of a bactericidal effect. in experimental infection in mice, t ...19816268594
[effects of ks-r1 (ampicillin suppository) and ampicillin oral dosing on fecal flora of children].a newly developed product, ks-r1 (a suppository containing 250 mg potency of ampicillin (abpc)), was given to 7 children (5 boys and 2 girls) ranging from 4 years and 5 months to 8 years and 10 months in age, 3 times a day (average daily dose, 62.4 mg/kg) for 5 days. as a control, the same amount of abpc dry syrup was given orally to 7 children (4 boys and 3 girls) ranging from 2 years and 8 months to 7 years and 7 months in age, 3 times a day (average daily dose, 55.3 mg/kg) for 5 days. the eff ...19853849603
efficacy of ceftizoxime administered twice daily in hospitalized patients with respiratory tract infections.the efficacy and safety of ceftizoxime administered twice daily were evaluated in 215 hospitalized patients with documented lower respiratory tract infections. the majority of patients received 1 to 2 gm of ceftizoxime intramuscularly or intravenously every 12 hours; the mean dosage was 2 gm/day, and the mean duration of therapy was 8.9 days. clinical cure was achieved in 204 (95%) of the 215 patients with lower respiratory tract infection. one hundred and thirty-eight patients were both clinica ...19846097357
in vitro activity of ro 15-8074 and ro 19-5247, two orally administered cephalosporin metabolites.the activity of two iminomethoxy aminothiazoly cephalosporins, ro 15-8074 and ro 19-5247, was compared with that of other beta-lactams against a total of 491 bacterial strains. both were highly active (mic for 90% of the strains tested [mic 90], less than or equal to 2 micrograms/ml) against the majority of the members of the family enterobacteriaceae, haemophilus influenzae, neisseria spp., and streptococcus pneumoniae, being at least 16-fold more active than cephalexin and 8-fold more active t ...19863729361
[effect of norfloxacin on bacterial flora in human feces].norfloxacin (nflx), a synthetic oral antibacterial agent of quinolone carboxylic acid, was given orally for 5 full days at a dose of 200 mg, three times daily after each meal to healthy normal men with ages between 22 and 25 years weighing 53.0 to 84.0 kg (average 67.0 kg). the actual regimen followed was that the drug was administered twice after lunch and supper on the first day of dosing, and once after breakfast on the last day of dosing. on the 5th day before the start of dosing, on the fir ...19873694785
isolations of aerobic bacteria from wild desert bighorn sheep (ovis canadensis nelsoni and o. c. mexicana) in arizona.nasal, pharyngeal, cervical and vaginal swab specimens were obtained from 74 desert bighorn sheep for the purpose of investigating the normal aerobic bacterial flora of wild sheep. a total of 281 isolates was obtained and identified by standard microbiologic tests. one hundred seven of these isolates were gram positive and included bacillus sp. (36%), staphylococcus epidermidis (8%), s. aureus (4%), corynebacterium sp. (diphtheroids, 4%), and streptococcus sp. (48%). gram negative isolates total ...19836887449
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