| effects of the gastric juice inhibitory substance from streptomyces bottropensis on gastric secretion and experimental ulcerations in rats. | | 1977 | 264182 |
| [new antibiotic no. 792 formed by actinomyces bottropensis]. | an actinomycetes strain 792 producing a new antibiotic was isolated under the programme of antitumor antibiotic screening. by its morphological and cultural properties strain 792 was classified as belonging to species actinomyces bottropensis. antibiotic 792 was recovered from the culture fluid of the strain by the extraction method in the form of a crystalline orange substances. lambda max 235, 305, 410 nm (e 1% 1cm 705, 105, 168), m. p. 232-255 degrees (dec), molecular weight 340, c 67 per cen ... | 1977 | 576572 |
| [biological characteristics of culture 6734-21 and the conditions for isolating the antiviral antibiotic it produces]. | an actinomyceteous strain no. 6734-21 was isolated from a soil sample of central asia and classified as actinomyces bottropensis. it inhibited the development of the phage of the lysogenic culture of micrococcus lysodeicticus 53-40 (no. 5) and the variolovaccine dna-containing virus. actinomyces bottropensis, strain no. 6734-21 produced an antiviral antibiotic classified as one belonging to the actinorodine group. | 1977 | 596850 |
| biological properties of the gastric juice inhibitory substance produced by streptomyces bottropensis f4708. | | 1978 | 647861 |
| [purification and partial characterization of the gastric juice inhibitory substance from culture filtrate of streptomyces bottropensis f4708]. | | 1976 | 987193 |
| 44-homooligomycins a and b, new antitumor antibiotics from streptomyces bottropensis. producing organism, fermentation, isolation, structure elucidation and biological properties. | oligomycin antibiotics, 44-homooligomycin a (nk86-0279 ii) and b (nk86-0279 i) are newly discovered antitumor antibiotics with the substitution of ethyl for methyl at carbon 26. they were isolated from the culture broth of streptomyces bottropensis nk86-0279. the structure of these two compounds was deduced by spectroscopic and x-ray crystallographic analyses. these antibiotics showed potent antitumor activities against various tumor cells in vitro, and were active against colon 26 carcinoma in ... | 1992 | 1556008 |
| phylogenetic analysis of streptomyces spp. causing potato scab based on 16s rrna sequences. | the complete 16s rrna sequences of 12 strains of streptomyces spp., including potato scab pathogens, were determined. among the strains of streptomyces scabies that were isolated from diverse geographical areas and differed in melanoid pigment production, either no difference or one difference in sequence was observed. the sequence of s. scabies was most similar to the sequences of streptomyces diastatochromogenes, streptomyces bottropensis, and streptomyces neyagawaensis, which belong to the di ... | 1996 | 8934906 |
| dna relatedness among strains of streptomyces pathogenic to potato in france: description of three new species, s. europaeiscabiei sp. nov. and s. stelliscabiei sp. nov. associated with common scab, and s. reticuliscabiei sp. nov. associated with netted scab. | the genomic relatedness was evaluated by dna-dna hybridization for 23 strains (21 were pathogenic and two were saprophytic strains) isolated from lesions of common and netted scab in france and 19 strains from other countries, including type strains of streptomyces species. three genomospecies were defined within the conventional species of streptomyces scabies, and these genomospecies were different from other pathogenic described species (streptomyces acidiscabies, streptomyces caviscabies) ba ... | 2000 | 10826791 |
| Cloning and Heterologous Expression of Three Type II PKS Gene Clusters from Streptomyces bottropensis. | Mensacarcin is a potent cytotoxic agent isolated from Streptomyces bottropensis. It possesses a high content of oxygen atoms and two epoxide groups, and shows cytostatic and cytotoxic activity comparable to that of doxorubicin, a widely used drug for antitumor therapy. Another natural compound, rishirilide A, was also isolated from the fermentation broth of S. bottropensis. Screening a cosmid library of S. bottropensis with minimal PKS-gene-specific primers revealed the presence of three differe ... | 2011 | 22162248 |
| Screening and Identification of Antimicrobial Compounds from Streptomyces bottropensis Suppressing Rice Bacterial Blight. | Xanthomonas oryzae pv. oryzae (Xoo) is the most devastating pathogen to Oryza sativa and has been shown to cause bacterial blight. Two bioactive compounds showing antimicrobial activities against Xoo strain KACC 10331 were isolated from a Streptomyces bottropensis strain. The ethyl acetate extract was fractionated on a Sephadex LH-20 column, and then purified by preparative HPLC. The purified compounds were identified as bottromycin A2 and dunaimycin D3S by HR/MS and 1H NMR analyses. The MIC val ... | 2011 | 22210608 |
| functional characterization of different orfs including luciferase-like monooxygenase genes from the mensacarcin gene cluster. | the biologically active compound mensacarcin is produced by streptomyces bottropensis. the cosmid cos2 contains a large part of the mensacarcin biosynthesis gene cluster. heterologous expression of this cosmid in streptomyces albus j1074 led to the production of the intermediate didesmethylmensacarcin (ddmm). in order to gain more insights into the biosynthesis, gene inactivation experiments were carried out by λ-red/et-mediated recombination, and the deletion mutants were introduced into the ho ... | 2015 | 25907804 |
| insights into the bioactivity of mensacarcin and epoxide formation by msno8. | mensacarcin, a potential antitumour drug, is produced by streptomyces bottropensis. the structure consists of a three-membered ring system with many oxygen atoms. of vital importance in this context is an epoxy moiety in the side chain of mensacarcin. our studies with different mensacarcin derivatives have demonstrated that this epoxy group is primarily responsible for the cytotoxic effect of mensacarcin. in order to obtain further information about this epoxy moiety, inactivation experiments in ... | 2014 | 24554499 |
| the sarp family regulator txn9 and two-component response regulator txn11 are key activators for trioxacarcin biosynthesis in streptomyces bottropensis. | trioxacarcin a is a polyoxygenated, structurally complex antibiotic produced by streptomyces spp., which possesses high anti-bacterial, anti-malaria, and anti-tumor activities. the trioxacarcin biosynthetic pathway involves type ii polyketide synthases (pkss) with l-isoleucine as a unique starter unit, as well as many complex post-pks tailoring enzymes and resistance and regulatory proteins. in this work, two regulatory genes, txn9 coding for a streptomyces antibiotic regulatory protein family r ... | 2015 | 26178900 |
| draft genome sequence of streptomyces bottropensis atcc 25435, a bottromycin-producing actinomycete. | a series of bottromycin antibiotics have been isolated and identified from streptomyces bottropensis strain atcc 25435. here, a draft genome sequence of s. bottropensis atcc 25435 is presented. the genome carries an intact biosynthetic gene cluster for bottromycin antibiotics, which provides insight into the combinatorial biosynthesis of bottromycin antibiotics. | 2013 | 23516178 |