| very high prevalence of hepatitis c virus genotype 6 variants in southern vietnam: large-scale survey based on sequence determination. | | 2011 | 22116339 |
| detection and clinical features of hepatitis c virus type 6 infections in blood donors from hong kong. | the genotype distribution of hepatitis c virus (hcv) was investigated in 212 viraemic blood donors from hong kong. a subset of the samples was investigated using three different genotyping assays to establish the accuracy of each in this population. these assays were restriction fragment length polymorphism (rflp) of amplified 5' noncoding region (5'ncr) sequences, rflp of the core region, and a serotyping assay using peptides from two antigenic regions of ns4. genotypes detected in hong kong bl ... | 1996 | 8915883 |
| the effects of il-28b and itpa polymorphisms on treatment of hepatitis c virus genotype 6. | | 2011 | 21540909 |
| geographic distribution of hepatitis c virus genotype 6 subtypes in thailand. | the nucleotide sequence of hepatitis c virus (hcv) genotype 6 found mostly in south china and south-east asia, displays profound genetic diversity. the aim of this study to determine the genetic variability of hcv genotype 6 (hcv-6) in thailand and locate the subtype distribution of genotype 6 in various geographic areas. four hundred nineteen anti-hcv positive serum samples were collected from patients residing in - the central part of the country. hcv rna positive samples based on reverse tran ... | 2010 | 20029811 |
| high prevalence of hepatitis c virus genotype 6 in vietnam. | this study aimed to update the prevalence of the various hepatitis c virus genotypes in vietnamese blood donors. one hundred and three hcv antibody-positive plasma samples were collected from blood donors at the national institute of hematology and blood transfusion, hanoi, vietnam. all specimens were subjected to rt-pcr of the 5' untranslated region (utr) to confirm the presence of hcv rna. the core and ns5b regions of thh positive samples were subsequently amplified by rt-pcr followed by direc ... | 2009 | 19839502 |
| entire genome sequences of two new hcv subtypes, 6r and 6s, and characterization of unique hvr1 variation patterns within genotype 6. | hepatitis c virus genotype 6 currently contains 21 recognized subtypes, 6a-6u, for which 6r and 6s lack complete genome sequences. in this study, we entirely sequenced variants qc245 and qc66 from cambodian immigrants in canada representing subtypes 6r and 6s, respectively. the two genomes shared 75.3% nucleotide similarities to each other and 72.0-82.9% to 21 reference sequences representing subtypes 6a-6q, 6t-6u and variants km41 and gz52557. qc66 and qc245 displayed genome lengths of 9473 and ... | 2009 | 19281488 |
| identification of hepatitis c virus genotype 6 in korean patients by analysis of 5' untranslated region using a matrix assisted laser desorption/ionization time of flight-based assay, restriction fragment mass polymorphism. | previous surveys of the prevalence of hepatitis c virus (hcv) in korea have identified types 1 and 2, but little has been said of other genotypes and viral subtypes. in this study, hcv genotypes in korea were investigated using restriction fragment mass polymorphism (rfmp) assay, a sensitive and specific method for genotyping based on maldi-tof mass spectrometry. a total of 1,043 independent serum samples from hcv-infected patients were analyzed. of interest, 15 subjects (1.4%) were determined t ... | 2008 | 18712825 |
| 222 base pairs in ns5b region and the determination of hepatitis c virus genotype 6. | the present study was performed to genotype hepatitis c virus (hcv) by direct sequencing of a 222-bp nucleotide in the ns5b region and comparing the results with those of direct sequencing in the core region. we investigated a new region for hcv genotyping which gave the best performance to discriminate hcv genotype 6a, the unique genotype found in southeast asia. | 2006 | 16491017 |
| response to combined interferon and ribavirin is better in patients infected with hepatitis c virus genotype 6 than genotype 1 in hong kong. | data on the treatment efficacy of interferon (ifn)-alpha and ribavirin in patients with chronic hepatitis infected with hepatitis c virus (hcv) of genotype 6 are lacking. a study has been reported from hong kong which compared the treatment efficacy of ifn-alpha and ribavirin in the treatment of chronic hcv infection with genotypes 1 and 6. twenty-four patients with hcv genotype 1 and 16 patients with hcv genotype 6 were studied. the baseline demographic data including median age, gender ratio, ... | 2006 | 16166796 |
| hepatitis c virus genotype 6 infection in india. | we report two patients with chronic liver disease--a 46-year-old man and a 52-year-old woman, both from eastern india--who were found to be infected with hepatitis c virus genotype 6 strains. these strains have been previously reported only from hong kong and southeast asia. | 2005 | 15879655 |
| comparative study of different methods to genotype hepatitis c virus type 6 variants. | hepatitis c virus (hcv) genotype 6a is found frequently in southeast asia. in thailand, however, genotype 6 variants may exist which posses a genotype 1 like sequence in the 5' non-coding region. in order to genotype correctly these viruses, four different methods; inno-lipa assay, two rflp assays on the core region (using different restriction enzymes) and phylogenetic analysis of the core sequences were compared. samples from 17 chronic hcv patients from the netherlands and thailand and 18 ant ... | 2003 | 12711063 |
| interferon and ribavirin therapy for chronic hepatitis c virus genotype 6: a comparison with genotype 1. | because there is a lack of data on the treatment outcome of patients who carry hepatitis c virus (hcv) genotype 6, we conducted a prospective study, to compare the effect of interferon and ribavirin therapy in hcv genotypes 1 and 6, of patients with seropositive anti-hcv, persistently elevated alanine transaminase levels, and detectable hcv rna. patients were treated with subcutaneous recombinant interferon alpha-2b and ribavirin for 12 months. of 40 patients, 16 had genotype 6, and 24 had genot ... | 2003 | 12660921 |
| high prevalence of hepatitis c virus genotype 6 among certain risk groups in hong kong. | the genotype of hepatitis c virus (hcv) of 172 hcv-rna positive serum specimens taken from patients with chronic liver diseases, thalassaemia major, chronic renal failure (crf), haemophilia and intravenous drug abusers (ivda) was determined by analysis of the amplified 5'utr region by genotype-specific oligonucleotide probes and restriction fragment length polymorphism (rflp). six different genotypes and subtypes (1a, lb, 2, 3, 4 and 6) were found. genotype lb was the predominant genotype among ... | 1998 | 9744672 |
| response-guided therapy for patients with hepatitis c virus genotype 6 infection: a pilot study. | the optimal duration of treatment with pegylated interferon (peg-ifn) plus ribavirin (rbv) in patients with hepatitis c virus (hcv) genotype 6 is unknown. this study was aimed at determining treatment response on the basis of rapid virological response (rvr) of hcv genotype 6 in comparison with genotypes 1 and 3. sixty-six treatment naïve patients were treated with peg-ifn-α2a (180 μg/week) plus weight-based rbv (1000-1200 mg/day). patients with genotype 1 n = 16) and genotype 3 (n = 16) were tr ... | 2011 | 22571904 |
| high genetic diversity including potential new subtypes of hepatitis c virus genotype 6 in lao people's democratic republic. | sera from 105 anti-hcv-positive first-time blood donors collected in 2004, 2005 and 2008 in different provinces in laos were investigated by pcr. forty-five samples were positive for hcv (42.86%); two belonged to subtype 1b (2/45, 4.4%) and all others to genotype 6 (43/45, 95.6%), including subtypes 6b, 6h, 6k, 6l, 6n and 6q. three groups of sequences were not clearly attributable to any genotype 6 subtype, two of which may be regarded as candidates for new subtypes of genotype 6. two samples we ... | 2011 | 21958219 |
| chronic hepatitis c virus genotype 6 infection: response to pegylated interferon and ribavirin. | to date, no study has evaluated pegylated interferon for the treatment of chronic infection with hepatitis c virus (hcv) genotype 6. we aimed to determine the efficacy of pegylated interferon plus ribavirin for treating infection with genotype 6 versus genotype 1. | 2008 | 18657036 |