| long-sarafotoxins: characterization of a new family of endothelin-like peptides. | sarafotoxins (srtxs) constitute a family of vasoactive peptides that were initially isolated from the venom of atractaspis engaddensis, and that are structurally and functionally related to endothelins (ets). analysis of the venom of atractaspis microlepidota microlepidota revealed several new srtx molecules manifesting some new structural and functional characteristics. these novel srtxs are longer by three amino acids than the previously described srtxs, and are designated here "long-srtxs". s ... | 2004 | 15350691 |
| preparation of a novel antivenom against atractaspis and walterinnesia venoms. | the two deadly snakes, walterinnesia aegyptia (black desert cobra) and atractaspis microlepidota (mole viper) share a common habitat in the central, eastern and western provinces of saudi arabia. bites by either snake were characterized by rapid death, sometimes before reaching any medical facility. confusing reports of "a black snake bite" are frequently found. the navpc had succeeded in preparing a highly effective antivenom against w. aegyptia venom which is now available in the market, but n ... | 2007 | 17097125 |
| pharmacological and structural characterization of long-sarafotoxins, a new family of endothelin-like peptides: role of the c-terminus extension. | long-sarafotoxins (l-srtxs) have recently been identified in both the venom of atractaspis microlepidota and that of atractaspis irregularis. they are characterized by different c-terminus extensions that follow the invariant trp21, which plays a crucial role in endothelin-receptor binding. we initially determined the toxicity and three-dimensional structures of two chemically synthesized l-srtxs that have different c-terminus extensions, namely srtx-m (24 aa, including extension "d-e-p") and sr ... | 2011 | 21889567 |
| antigenic relationships of the venom of atractaspis microlepidota to that of other snakes. | | 1968 | 4974853 |
| respiratory effects of sarafotoxins from the venom of different atractaspis genus snake species. | sarafotoxins (srtx) are endothelin-like peptides extracted from the venom of snakes belonging to the atractaspididae family. a recent in vivo study on anesthetized and ventilated animals showed that sarafotoxin-b (srtx-b), extracted from the venom of atractaspis engaddensis, decreases cardiac output by inducing left ventricular dysfunction while sarafotoxin-m (srtx-m), extracted from the venom of atractaspis microlepidota microlepidota, induces right ventricular dysfunction with increased airway ... | 2016 | 27409637 |
| a fatal bite from the burrowing asp atractaspis corpulenta (hallowell 1854). | bites from the various species of atractaspis are a common occurrence in africa but deaths are very unusual. of the 19 described species, the clinical effects of the bite of only seven have been described, and in only three (atractaspis irregularis, atractaspis microlepidota and atractaspis engaddensis) have fatalities been documented. a case of envenomation is described following a bite to a finger by atractaspis corpulenta, which resulted in sudden death approximately two and a half hours late ... | 2016 | 27090012 |
| short- versus long-sarafotoxins: two structurally related snake toxins with very different in vivo haemodynamic effects. | sarafotoxin-m (24 amino acids) from the venom of atractaspis microlepidota microlepidota was the first long-sarafotoxin to be identified, while sarafotoxin-b (21 aa) is a short-sarafotoxin from atractaspis engaddensis. despite the presence of three additional c-terminus residues in sarafotoxin-m, these two peptides display a high sequence homology and share similar three-dimensional structures. however, unlike sarafotoxin-b, sarafotoxin-m shows a very low in vitro affinity for endothelin recepto ... | 2015 | 26176218 |
| poisoning by the sudan mole viper atractaspis microlepidota günther. | | 1954 | 13216939 |