Publications

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the ability of anopheles gambiae giles to transmit brugia patei (buckley, nelson & heisch). 196113759677
the behaviour and development of brugia patei (buckley, nelson and heisch, 1958) in a mosquito host, mansonia uniformis (theobald). 196114462812
epidemiology of canine heartworm infection.factors affecting transmission of d. immitis between dogs are summarized in table 4. although this list may not be exhaustive, it illustrates the complexity of heartworm epidemiology. there are interesting and provocative similarities in the epidemiology of canine and human filariasis. ottesen (148) has described the spectrum of disease observed in regions endemic for lymphatic filariasis. it includes patients with 1) microfilariae, but no symptoms; 2) disease, but no microfilariae; 3) tropical ...19836139288
life cycle of brugia patei (buckley, nelson, and heisch, 1958) in the jird, meriones unguiculatus. 19734722591
abnormal development of a filarial worm, brugia patei (buckley, nelson and heisch), in a mosquito host, anopheles labranchiae atroparvus van thiel. 19744430822
adaptatio of a filarial worm, brugia patei, to a new mosquito host, aedes togoi. 19674383333
polyamine metabolism in filarial worms.the human and animal filarial parasites onchocerca volvulus, dirofilaria immitis, brugia patei and litomosoides carinii contained low levels of putrescine but much higher levels of spermidine and spermine as estimated by ion-pair high pressure liquid chromatography; n-acetylated polyamines were present only in minute amounts. enzyme activities of ornithine decarboxylase (ec 4.1.1.17) and arginine decarboxylase (ec 4.1.1.19), respectively, were not detectable. experiments carried out with o. volv ...19873627168
filaricidal effect of mefloquine on adults and microfilariae of brugia patei and brugia malayi.mefloquine, dl-erythro-2,8-bis(trifluoromethyl)-alpha-(2-piperidyl)-4-quinoline methanolhydrochloride, a recently developed antimalarial drug shows filaricidal activity against larval and adult stages of brugia patei and b. malayi maintained "in vitro". in the concentration range of 10 to 2 microm mefloquine paralysed and killed the filarial worms within 10 h and 3 d, respectively. the lethal effect of mefloquine treatment on larval and adult worms was shown by loss of motility as well as by dec ...19873496653
synthetic pathways of glycerophospholipids in adult brugia pahangi and brugia patei. 19873429123
lectin binding to larval stages of brugia patei.surface properties of microfilariae (mf) and infective larvae of brugia patei were investigated to compare them to previous studies with the other brugian species. of all the lectins tested, only wheat germ agglutinin (wga) binds to the sheath surface of mf indicating the presence of n-acetyl-d-glucosamine as a major surface carbohydrate. however, cuticle of infective larvae failed to show binding of these lectins. enzyme treatment of mf with n-acetyl-d-glucosaminidase and l-fucosidase has expos ...19892807723
a direct fluorescence technique for the rapid detection of sheathed microfilariae in blood smears.thick and thin blood smears containing microfilariae of wuchereria bancrofti, loa loa, brugia malayi, brugia pahangi, brugia patei or acanthocheilonema viteae were prepared from either cryopreserved blood samples or from freshly collected blood, fixed in methanol and treated with a fluoresceinated lectin wheat germ agglutinin. sheathed microfilariae of w. bancrofti, l. loa, b. malayi, b. pahangi and b. patei in the blood smears could be easily detected and counted using a fluorescence assay. the ...19902074139
variations in complement activation of brugia patei, b. malayi and b. pahangi microfilariae.the complement of fresh normal heterozygotic balb/c (nu/+) and nude (nu/nu) mice was activated by sheathed microfilariae (mf) of brugia malayi and b. pahangi but not by b. patei. mouse c3 was detected by immunofluorescence on the sheathed surface of b. malayi and b. pahangi mf but not on b. patei mf. the bound complement promoted macrophage and neutrophil mediated adherence and cytotoxicity to these mf. however, balb/c nu/+ or nu/nu mouse macrophages and neutrophils adhered to exsheathed mf of b ...19912030522
brugia malayi, brugia pahangi, and brugia patei: pulmonary pathology in jirds, meriones unguiculatus. 1976976421
hybridization between brugia patei, b. pahangi and sub-periodic b. malayi.virgin females of brugia malayi, b. pahangi and b. patei were mated with males of species other than their own to determine whether they would hybridize. microfilariae were produced in all but one cross (that between b. pahangi males and b. malayi females). hybrid infective larvae, produced in mosquitoes and inoculated intraperitoneally into jirds, grew to adults but these were unable to produce microfilariae because hybrid males did not produce spermatozoa. hybrid females were fertile and produ ...1978704146
incorporation of radioactive precursors into filarial larvae of brugia developing in susceptible and refractory mosquitoes.the incorporation of tritiated precursors injected into mosquito hosts parasitized by developing filarial larvae of brugia patei has been studied by autoradiography in 2 species of mosquito, aedes togoi in which filarial development was normal and anopheles labranchiae atroparvus in which filarial development was abnormal. in both mosquito hosts there was significant incorporation into 4--5-day-old developing larvae of uridine and amino acids (isoleucine, leucine, valine, arginine, lysine, cysti ...197941893
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