| inhibition of the human chemokine receptor ccr5 by variecolin and variecolol and isolation of four new variecolin analogues, emericolins a-d, from emericella aurantiobrunnea. | an extract from the fungus emericella aurantiobrunnea was found to compete with macrophage inflammatory protein (mip)-1alpha for binding to human ccr5 in a scintillation proximity assay (spa). bioassay-guided fractionation led to the isolation of variecolin (1) and variecolol (2), which had ic50 values of 9 and 32 microm, respectively. an x-ray crystal structure of variecolin (1) was obtained for the first time. also isolated were four new inactive analogues, emericolin a (3), b (4), c (5), and ... | 2004 | 15497939 |