| [studies on the components of atractylodes. i. new sesquiterpenoids in the rhizone of atractylodes lancea de candolle (author's transl)]. | | 1976 | 988162 |
| antagonism by beta-eudesmol of neostigmine-induced neuromuscular failure in mouse diaphragms. | beta-eudesmol, a sesquiterpenol extracted from a chinese herb, atractylodes lancea, at 10-80 microm, did not affect muscle action potentials, miniature and evoked endplate potentials and acetylcholine-induced depolarization in the presence or absence of neostigmine in mouse phrenic nerve-diaphragms. however, the tetanic fade, muscle fasciculation and twitch potentiation induced by neostigmine were effectively antagonized by 20 microm beta-eudesmol. when trains of pulses were applied to the nerve ... | 1992 | 1397007 |
| [the effects of crude drugs using diuretic on horse kidney (na+ + k+)-adenosine triphosphatase]. | in the folk-medicine, several kinds of crude drugs are used as diuretics. twenty three kinds of diuretic drugs were chosen, and examined for their effects on the horse kidney (na+ + k+)-adenosine triphosphatase (atpase), which is an intrinsic enzyme of the plasma membrane and responsible for the active transport of na+ and k+ across the membrane. twenty one out of twenty three kinds of ethanol extracts of diuretic drugs inhibited the kidney (na+ + k+)-atpase activity. the intensity of the inhibi ... | 1991 | 1647455 |
| mechanism of the blocking action of beta-eudesmol on the nicotinic acetylcholine receptor channel in mouse skeletal muscles. | beta-eudesmol, an uncharged alcohol contained in atractylodes lancea, blocks the neuromuscular junction. atractylodes lancea is prescribed in a traditional chinese medicine and plays a main role for "alleviation of pain in skeletal muscle". by using the cell-attached patch-clamp or conventional intracellular technique, the site of action of beta-eudesmol on the nicotinic acetylcholine (ach) receptor (nachr) channel in skeletal muscle of the adult mouse, was investigated and compared with that of ... | 1991 | 1780041 |
| noncontractile acetylcholine receptor-operated ca++ mobilization: suppression of activation by open channel blockers and acceleration of desensitization by closed channel blockers in mouse diaphragm muscle. | the effects of various blockers of the nicotinic acetylcholine receptor-activated ionic channel on noncontractile slow ca++ mobilization were investigated at the neuromuscular synapse of aequorin-injected diaphragm muscles of mice. intracellular ca++ mobilization (ca++ transients) was evoked in the presence of neostigmine (0.3 microm) by nerve stimulation. bupivacaine, an open channel blocker, decreased the peak amplitude, whereas chlorpromazine, a closed channel blocker, shortened the duration. ... | 1991 | 1988657 |
| studies on the origin, processing and quality of crude drugs. ii. pharmacological evaluation of the chinese crude drug "zhu" in experimental stomach ulcer. (2). inhibitory effect of extract of atractylodes lancea on gastric secretion. | | 1986 | 3815607 |
| [studies on the origin, processing and quality of crude drugs. iii. pharmacological evaluations of the chinese drug "zhu" in experimental stomach ulcer (3) effect of extract of atractylodes lancea var. chinensis on gastric secretion]. | | 1985 | 4093860 |
| [studies on the origin, processing and quality of crude drugs. iv. pharmacological evaluation of the chinese drug "zhu" in experimental stomach ulcer (4) the cytoprotective effect of extract of atractylodes lancea var. chinensis]. | | 1985 | 4093861 |
| 5-lipoxygenase and cyclooxygenase-1 inhibitory active compounds from atractylodes lancea. | lipophilic extracts of atractylodes lancea rhizomes exhibited potent inhibitory activities in 5-lipoxygenase [ic50 (5-lox) = 2.9 micrograms/ml (n-hexane extract)] and cyclooxygenase-1 [ic50 (cox-1) = 30.5 micrograms/ml (n-hexane extract)] enzymatic assays. bioactivity-guided fractionation of the n-hexane extract led to the isolation of a new compound atractylochromene (1), a potent inhibitor in both test systems [ic50 (5-lox) = 0.6 microm, ic50 (cox-1) = 3.3 microm]. also obtained was 2-[(2e)-3, ... | 1998 | 9544564 |
| biotransformation of hinesol isolated from the crude drug atractylodes lancea by aspergillus niger and aspergillus cellulosae. | biotransformation of the sesquiterpene alcohol hinesol (1) with spasmolytic activity, which was prepared from the rhizome of atractylodes lancea, was carried out by aspergillus niger and aspergillus cellulosae ifo 4040. compound 1 was easily converted to compounds 2-9 by a. niger, and compounds 10 and 11 by a. cellulosae, respectively. their stereostructures were established by a combination of high-resolution nmr spectral analysis, x-ray crystallographic analysis, and chemical reactions such as ... | 1999 | 10361702 |
| acidic polysaccharides from rhizomes of atractylodes lancea as protective principle in candida-lnfected mice. | prophylactic effects upon imunnosuppressed mice lethally infected by candida albicans were examined in fractions prepared from a constituent herb of juzen-taiho-to (tj-48, si-quan-da-bu-tang), rhizomes of atractylodes lancea dc. the oral administration of water extract obtained from a residue after meoh extraction of rhizomes significantly prolonged the survival period of the infected mice at a dose of 140 mg/kg/day compared with control mice, while the meoh extract did not. in the crude polysac ... | 2001 | 11488456 |
| effect of the rhizomes of atractylodes lancea and its constituents on the delay of gastric emptying. | the effect of rhizomes of atractylodes lancea on gastric disorders, in particular, the delay in gastric emptying induced by n(g)-nitro-l-arginine in rats, was investigated. intragastric treatment with an aqueous extract (250 mg/kg) and its lipophilic fractions (4 mg/kg) significantly improved delayed gastric emptying. the major constituents of the lipophilic fraction were two sesquiterpens, hinesol and beta-eudesmol, and four known polyacetylenic compounds, atractylodin, atractylodinol, acetylat ... | 2003 | 12499077 |
| determination of the effectiveness of components of the herbal medicine toki-shakuyaku-san and fractions of angelica acutiloba in improving the scopolamine-induced impairment of rat's spatial cognition in eight-armed radial maze test. | the improving effects of various components of toki-shakuyaku-san (tss) and fractions isolated from angelica acutiloba radix (toki) on scopolamine-induced spatial memory impairment were investigated in eight-armed radial maze. the scopolamine-induced memory impairment was characterized by prominent increase of error choices in addition to decreased correct choices. toki, cnidium officinale rhizoma (senkyu), poria cocos hoelen (bukuryo), alisma orientale rhizoma (takusha), and atractylodes lancea ... | 2004 | 15351791 |
| identification of panax species in the herbal medicine preparations using gradient pcr method. | in order to identify the existence of panax species in herbal medicine preparations, the ginseng specific marker primer was selected and created based on the sequence of korean ginseng dna fragment, 359 bp. the gradient pcr was performed on 40 types of the herbal medicines including the 7 types of araliaceae that are in the same family with the panax ginseng using the created ginseng maker primer. as result, panax notoginseng (chinese), panax japonicus (japanese) and panax quinquefolius (america ... | 2005 | 15802808 |
| antiangiogenic activity of beta-eudesmol in vitro and in vivo. | abnormal angiogenesis is implicated in various diseases including cancer and diabetic retinopathy. in this study, we examined the effect of beta-eudesmol, a sesquiterpenoid alcohol isolated from atractylodes lancea rhizome, on angiogenesis in vitro and in vivo. proliferation of porcine brain microvascular endothelial cells and human umbilical vein endothelial cells (huvec) was inhibited by beta-eudesmol (50-100 microm). it also inhibited the huvec migration stimulated by basic fibroblast growth ... | 2005 | 15840394 |
| [habitat characteristics for the growth of atractylodes lancea based on gis]. | to study the habitat characteristics for the growth of atractylodes lancea. | 2005 | 16011274 |
| [the status and changes of soil nutrients in rhizosphere of cultivated atractylodes lancea]. | to find the status and changes of the soil nutrients in rhizosphere of atractylodes lancea. | 2005 | 16335818 |
| [effects of intercropping peanut with medicinal plants on soil microbial community]. | with pot experiment, this paper studied the quantitative variations of bacteria, actinomyces, mould and yeast in soils of peanut intercropped with medicinal plants, aimed to test if such an intercropping pattern could remove the obstacles of peanut's continuous cropping. the results showed that atractylodes lancea and euphorbia pekinensis had the strongest inhibitory effect on mould. compared with ck (mono-cropping peanut), the cfu of mould in the treatments intercropped with a. lancea and e. pe ... | 2007 | 17552215 |
| [key influencing factors on essential oil components of atractylodes lancea and study on its division of climate adaptability]. | to find the key factors that influence the content of the essential oil components of atractylodes lancea and classify the habitat of a. lancea based the essential oil components, as well as explore a new method to conduct division of chinese natural medicin through geographic information system (gis) ultimately. | 2007 | 17655137 |
| [change of microbial community in rhizoma sphere of cultivated atractylodes lancea]. | to find the development rules of microbial community in rhizoma sphere of the cultivated atractylodes lancea. | 2007 | 17802868 |
| [construction and application of special analysis database of geoherbs based on 3s technology]. | in this paper,the structures, data sources, data codes of "the spacial analysis database of geoherbs" based 3s technology are introduced, and the essential functions of the database, such as data management, remote sensing, spacial interpolation, spacial statistics, spacial analysis and developing are described. at last, two examples for database usage are given, the one is classification and calculating of ndvi index of remote sensing image in geoherbal area of atractylodes lancea, the other on ... | 2007 | 17993009 |
| regulative effects of essential oil from atractylodes lancea on delayed gastric emptying in stress-induced rats. | gastric motor dysfunction induced by psychological stress results in many symptoms of functional dyspepsia (fd). there are a number of herbal medicines that are reported to improve gastrointestinal motor. however, the mechanisms of considerable herbal medicines are not explicit. in the present study, the effects of an essential oil (eo) extracted from atractylodes lancea on delayed gastric emptying, gastrointestinal hormone and hypothalamic corticotropin-releasing factor (crf) abnormalities indu ... | 2008 | 18430552 |
| [transcriptional regulation of cytochrome p450 3a4 by four kinds of traditional chinese medicines]. | to screen a group of traditional chinese medicines with effect on pregnane x receptor (pxr)-mediated transcription regulation of p450 3a4 (cyp3a4); and to study whether they can induce the expression of cyp3a4 with a dose, time-dependent manner. | 2008 | 18652346 |
| traditional chinese medicine for atopic eczema: pentaherbs formula suppresses inflammatory mediators release from mast cells. | pentaherbs formula (phf) containing cortex moutan, root bark of paeonia suffruticosa andr. (ranunculaceae), cortex phellodendri, bark of phellodendron chinensis schneid. (rutaceae), flos lonicerae, flower of lonicera japonica thunb. (capri-foliaceae), herba menthae, aerial part of mentha haplocalyx briq. (labiatae) and rhizoma atractylodis, rhizome of atractylodes lancea (thunb.) dc. (compositae) at the ratio of 2:2:2:1:2 was useful in the management of eczema. | 2008 | 18725279 |
| [analysis in distribution of atractylodes lancea at maoshan regions]. | to investigate the distribution of atractylodes lancea at maoshan regions. | 2008 | 18826135 |
| [study on effect of drought stress on physiological adaptation of seedlings of atractylodes lancea]. | to study the effect of drought stress on the changes of physiological adaptation of atractylodes lancea seedlings. | 2008 | 19165996 |
| screening anti-inflammatory components from chinese traditional medicines using a peritoneal macrophage/cell membrane chromatography-offline-gc/ms method. | we report the development of an analytical method combining cell membrane chromatography (cmc) with gas chromatography/mass spectrometry (gc/ms). this was applied to the purification and identification of anti-inflammatory components from traditional chinese medicines. the stationary phase of the cmc employed mouse peritoneal macrophage (pm) cell membranes. we investigated the performance of the pm/cmc-offline-gc/ms method using hydrocortisone (hc) and dexamethasone (dm) as standards. the method ... | 2009 | 19664972 |
| [advances in chemistry, molecular biology and pharmacological of cangzhu]. | we described chemical composition in cangzhu in recent years, volatile oil is the important chemical composition, the beta-eudesmol, hinesol are active ingredient in volatile oil and there are 38 kind of glycosides. at the same time, we overview the applying of rapd technology in atractylodes lancea. the results is that there are correlation in chemical composition, genetic differentiation and geographical distribution, there is some truth in bounded by a territorial division of the north-south ... | 2009 | 20069912 |
| [role of nitric oxide and hydrogen peroxide in the essential oil increasing of suspension cells from atractylodes lancea induced by endophytic fungal cunninghamella sp. al4 elicitor]. | crude elicitor of one endophytic fungi (belong to cunninghamella sp., named al4) induced multiple responses in atractylodes lancea suspension cells, including rapid generation of nitric oxide (no) and hydrogen peroxide (h2o2), sequentially followed by enhancement of essential oil production. adding no-specific scavenger 2-4-carboxyphenyl-4,4,5, 5-tetramethylimidazol ine-1-oxyl-3-oxide (cptio) and h2o2 scavenger catalase (cat) could block elicitor-induced no and h2o2 generation respectively, but ... | 2009 | 20112693 |
| [antimicrobial activity of volatile oil from atractylodes lancea against three species of endophytic fungi and seven species of exogenous fungi]. | in order to investigate the inhibitory effects of host plants secondary metabolites on the growth of endophytic and exogenous fungi, the volatile oil from medicinal plant atractylodes lancea was extracted with organic solvent extraction method, and its antimicrobial activity against three species of endophytic and seven species of exogenous fungi was determined by paper disc assay and spread-plate. the volatile oil had inhibitory effects on the growth of test endophytic fungi. it had strong anti ... | 2009 | 20136016 |
| the regulatory mechanism of β-eudesmol is through the suppression of caspase-1 activation in mast cell-mediated inflammatory response. | β-eudesmol is sesquiterpenoid alcohol which contains the rhizome of atractylodes lancea. although it has multiple pharmacological effects, the anti-inflammatory effect of β-eudesmol and its molecular mechanisms are poorly elucidated. in this study, we investigated the regulatory mechanism of β-eudesmol on mast cell-mediated inflammatory response. the results indicated that β-eudesmol inhibited the production and expression of interleukin (il)-6 on phorbol 12-myristate 13-acetate and calcium iono ... | 2011 | 20604677 |
| cloning and characterization of a novel 3-hydroxy-3-methylglutaryl coenzyme a reductase gene from salvia miltiorrhiza involved in diterpenoid tanshinone accumulation. | the 3-hydroxy-3-methylglutaryl-coa reductase (hmgr) catalyzes the conversion of hmg-coa to mevalonate (mva), which is a rate-limiting step in the isoprenoid biosynthesis via the mva pathway. in this study, the full-length cdna encoding hmgr (designated as smhmgr2, genbank accession no. fj747636) was isolated from salvia miltiorrhiza by rapid amplification of cdna ends (race). the cloned gene was then transformed into the hairy root of s. miltiorrhiza, and the enzyme activity and production of di ... | 2011 | 20637524 |
| use of yokukansan (tj-54) in the treatment of neurological disorders: a review. | kampo herbal remedies are reported to have a wide range of indications and have attracted attention due to reports suggesting that these remedies are effective when used in disease treatment while maintaining a favourable quality of life. yokukansan, also known as tj-54, is composed of seven herbs; angelica acutiloba, atractylodes lancea, bupleurum falcatum, poria cocos, glycyrrhiza uralensis, cnidium officinale and uncaria rhynchophylla. yokukansan is used to treat insomnia and irritability as ... | 2010 | 20812276 |
| [pharmacological research of wild and cultivated atractylodes lancea]. | to explore the differences of the main pharmacological action in wild and cultivated atractylodes lancea. | 2010 | 20862974 |
| cytotoxic activity of thai medicinal plants against human cholangiocarcinoma, laryngeal and hepatocarcinoma cells in vitro. | cholangiocarcinoma is a serious public health in thailand with increasing incidence and mortality rates. the present study aimed to investigate cytotoxic activities of crude ethanol extracts of a total of 28 plants and 5 recipes used in thai folklore medicine against human cholangiocarcinoma (cl-6), human laryngeal (hep-2), and human hepatocarcinoma (hepg2) cell lines in vitro. | 2010 | 20920194 |
| [comparative study of effect of atractylodes lancea between geo-authentic and non-authentic producing areas on collagen-induced arthritis in rats]. | to compare the effects of atractylodes lancea from different producing area on collagen-induced arthritis (cia) in rats. | 2010 | 21246829 |
| blockade of il-6 secretion pathway by the sesquiterpenoid atractylenolide iii. | atractylenolide iii (1) is the major bioactive component of atractylodes lancea. the aim of this study was to analyze the effect on the regulation of interleukin (il)-6 secretion pathway caused by 1. this sesquiterpenoid inhibited the secretion and expression of il-6 in phorbol 12-myristate 13-acetate- and calcium ionophore a23187-stimulated human mast cells (hmc)-1. in addition, 1 inhibited histamine release in stimulated hmc-1 cells. in stimulated hmc-1 cells, 1 suppressed activation of p38 mi ... | 2011 | 21302967 |
| [effect of endophytic fungal elicitors on growth and atractylodin accumulation of cell suspension cultures of atractylodes lancea]. | to investigate the effects of endophytic fungal elicitors on the growth and atractylodin accumulation of cell suspension cultures of atractylodes lancea. | 2011 | 21473147 |
| taguchi approach for anti-heat stress prescription compatibility in mice spleen lymphocytes in vitro. | heat stress (hs) may induce immunosuppression as well as inhibit the proliferation of lymphocytes. this study evaluated the effects on immune function of our prescription on splenic lymphocytes under hs as well as its compatibility. the effects of four herbal extracts from agastache rugosa, atractylodes lancea, cortex phellodendri, and gypsum fibrosum on heat treated splenic lymphocytes were investigated and the compatibility of the prescription was also explored by using the taguchi method. thi ... | 2011 | 21811919 |
| A new 9-nor-atractylodin from Atractylodes lancea and the antibacterial activity of the atractylodin derivatives. | A new compound, namely, 9-nor-atractylodin (1) and one known atractylodin (2) were isolated from the rhizomes of Atractylodes lancea. The structural modifications of atractylodin were carried out and a series of atractylodin derivatives (3-10) were obtained. The antibacterial activities of 1-10 were examined against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Candida albicans. Compounds 4 and 8, which contained the a, ß-unsaturated carbonyl fragment, were found to be active ag ... | 2012 | 22061661 |
| comparison of the effects of fungal endophyte gilmaniella sp. and its elicitor on atractylodes lancea plantlets. | the effects of the endophytic fungus gilmaniella sp. and its elicitor on the defense and metabolic responses of host plants atractylodes lancea were investigated, in order to understand how to utilize endophytic fungi and their elicitor resources better. the results showed that the promotion effect of the fungus on the growth of host plantlets was much better than that of its elicitor. both fungus and elicitor enhanced defense-related enzyme activities. in fungus-inoculated groups, phenylalanine ... | 2011 | 22806853 |
| [screening and identification of an endophytic fungus from atractylodes lancea which utilizes volatile oil selectively]. | in order to transform main active ingredient of volatile oil, endophytic fungi were screened from the root of atractylodes lancea. transformation method was used in vitro. the changes of volatile oil were traced by gas chromatography. one endophytic fungus (strain alg-13) which could uitilize volatile oil selectively was screened. single factor experiment were conducted for exploring the effects of various factors that including kinds of carbon source, speed, liquid volume, ph and concentration ... | 2012 | 23270221 |
| the mechanism of ethylene signaling induced by endophytic fungus gilmaniella sp. al12 mediating sesquiterpenoids biosynthesis in atractylodes lancea. | ethylene, the first known gaseous phytohormone, is involved in plant growth, development as well as responses to environmental signals. however, limited information is available on the role of ethylene in endophytic fungi induced secondary metabolites biosynthesis. atractylodes lancea is a traditional chinese herb, and its quality depends on the main active compounds sesquiterpenoids. this work showed that the endophytic fungus gilmaniella sp. al12 induced ethylene production in atractylodes lan ... | 2016 | 27047528 |
| endophytic bacterium-triggered reactive oxygen species directly increase oxygenous sesquiterpenoid content and diversity in atractylodes lancea. | oxygenous terpenoids are active components of many medicinal plants. however, current studies that have focused on enzymatic oxidation reactions cannot comprehensively clarify the mechanisms of oxygenous terpenoid synthesis and diversity. this study shows that an endophytic bacterium can trigger the generation of reactive oxygen species (ros) that directly increase oxygenous sesquiterpenoid content and diversity in atractylodes lancea. a. lancea is a famous but endangered chinese medicinal plant ... | 2016 | 26712554 |
| anti-uv/hiv activity of kampo medicines and constituent plant extracts. | in order to search for new biological activities of kampo medicines and their constituent plant extracts, we investigated whether they protect the cells from the cytotoxicity induced by uv irradiation and human immunodeficiency virus (hiv) infection. | 2012 | 23160685 |
| one-pot synthesis of branched oligosaccharides by use of galacto- and mannopyranosyl thioglycoside diols as key glycosylating agents. | we describe in this paper the efficient four-component one-pot synthesis of three fully protected oligosaccharides 22, 36, and 50 with di-branched structures by employing d-galacto- and mannopyranosyl thioglycoside diols as central glycosylating agents. after global deprotection, they were converted respectively into the 3-aminopropyl linker-containing free oligosaccharide fragments 14, 24, and 38 structurally related to cell wall oligosaccharides from atractylodes lancea dc, the marine fungus l ... | 2013 | 23657837 |
| anticancer activity of atractylodes lancea (thunb.) dc in a hamster model and application of pet-ct for early detection and monitoring progression of cholangiocarcinoma. | opisthorchis viverrini (ov)-induced cholangiocarcinoma (cca) is an important cancer in the great mekong region, particularly in thailand. limitations of treatment options and the lack of an effective diagnostic tool for early detection of cca are major concerns for the control of this type of cancer. the aim of the study was to investigate anti-cca activity of the ethanolic extract of atractylodes lancea (thunb.) dc., and the applicability of positron emission tomography-computed tomography (pet ... | 2015 | 26434829 |
| traditional herbal medicine for the control of tropical diseases. | throughout history, traditional herbal medicine has afforded a rich repository of remedies with diverse chemical structures and bioactivities against several health disorders. a common issue of herbal medicine is the limitation of information on their pharmacological activities and their active constituents. traditionally, the use of herbal medicine has been based on empirical treatment and passed on from generation to generation with information available only in local journals. this prevents s ... | 2014 | 25425945 |
| studies on the isolation of photobacterium damselae subsp. piscicida from diseased golden pompano (trachinotus ovatus linnaeus) and antibacterial agents sensitivity. | an epizootic occurred among cultured golden pompano (trachinotus ovatus); it involved mass mortality on fish farms in linshui in hainan province, china, in 2008. diseased fish exhibited no obvious clinical signs, but pathological studies showed that nodules were scattered over the spleen and kidney. to investigate the nature of the pathogen, we studied the surviving fish, and a gram-negative bacterium (designated strain tos1) was isolated from the spleens of golden pompano. pathogenicity assays ... | 2013 | 23140939 |
| reactive oxygen species and hormone signaling cascades in endophytic bacterium induced essential oil accumulation in atractylodes lancea. | pseudomonas fluorescens induces gibberellin and ethylene signaling via hydrogen peroxide in planta . ethylene activates abscisic acid signaling. hormones increase sesquiterpenoid biosynthesis gene expression and enzyme activity, inducing essential oil accumulation. atractylodes lancea is a famous chinese medicinal plant, whose main active components are essential oils. wild a. lancea has become endangered due to habitat destruction and over-exploitation. although cultivation can ensure productio ... | 2016 | 27125387 |
| volatiles released by endophytic pseudomonas fluorescens promoting the growth and volatile oil accumulation in atractylodes lancea. | atractylodes lancea is a well-known, but endangered, chinese medicinal plant whose volatile oils are its main active components. as the volatile oil content in cultivated a. lancea is much lower than that in the wild herb, the application of microbes or related elicitors to promote growth and volatile oil accumulation in the cultivated herb is an important area of research. this study demonstrates that the endophytic bacterium pseudomonas fluorescens aleb7b isolated from the geo-authentic a. lan ... | 2016 | 26874622 |
| antagonistic mechanisms of endophytic pseudomonas fluorescens against athelia rolfsii. | to explore specific mechanisms of endophytic pseudomonas fluorescens antagonizing athelia rolfsii, causing southern blight of atractylodes lancea and to evaluate the potential of this ps. fluorescens strain to control southern blight. | 2014 | 24962812 |
| anticancer activities against cholangiocarcinoma, toxicity and pharmacological activities of thai medicinal plants in animal models. | chemotherapy of cholangiocarcinoma (cca), a devastating cancer with increasing worldwide incidence and mortality rates, is largely ineffective. the discovery and development of effective chemotherapeutics is urgently needed. | 2012 | 22448640 |
| drought degree constrains the beneficial effects of a fungal endophyte on atractylodes lancea. | plants, fungal endophytes (fes) and the changing environment interact with each other forming an interlaced network. this study evaluates nonadditive and interactive effects of the fe acremonium strictum and drought treatment on atractylodes lancea plantlets. | 2014 | 25080260 |
| consequences of antagonistic interactions between endophytic fungus and bacterium on plant growth and defense responses in atractylodes lancea. | many studies have examined pair-wise interactions between plants and endophytes, while overlooking the interplays among multiple endosymbionts and their combined impacts on hosts. in this study, atractylodes lancea plantlets were inoculated with endophytic fungus acremonium strictum al16, or endophytic bacterium acinetobacter sp., or both, to investigate the impacts of the three-way symbiosis on the host. our results showed that defense-related responses of the co-inoculated plantlets were delay ... | 2015 | 24293321 |
| regionalization of chinese material medical quality based on maximum entropy model: a case study of atractylodes lancea. | atractylodes is an east-asiatic endemic genera that distributed in china, japan and russian far eastern. as an important resource of medicinal plant, atractylodes has long been used as herbal medicine. to example the significant features in its trueborn quality and geographical distribution, we explored the relationships between medicine quality and habitat suitability in two classifications-lower atractylodin content than the standard of chinese pharmacopoeia (2010) and the other has higher con ... | 2017 | 28205539 |
| four new c10-polyacetylene glycosides from the rhizomes of atractylodes lancea. | an ongoing phytochemical investigation of the rhizomes of atractylodes lancea resulted in the isolation of four new c10-type polyacetylene glycosides (1-4). their structures were elucidated on the basis of extensive spectroscopic data (uv, ir, 1d and 2d nmr, and hresims). the absolute configurations of compounds 2-4 were determined by comparing the specific rotations of their aglycones. notably, compounds 2 and 3 exhibited significant hepatoprotective activities against apap-induced hepg2 cell i ... | 2017 | 27790920 |
| differentiation of essential oils in atractylodes lancea and atractylodes koreana by gas chromatography with mass spectrometry. | atractylodes rhizome is a valuable traditional chinese medicinal herb that comprises complex several species whose essential oils are the primary pharmacologically active component. essential oils of atractylodes lancea and atractylodes koreana were extracted by hydrodistillation, and the yield was determined. the average yield of essential oil obtained from a. lancea (2.91%) was higher than that from a. koreana (2.42%). the volatile components of the essential oils were then identified by a gas ... | 2016 | 27790838 |
| six new compounds from atractylodes lancea and their hepatoprotective activities. | two new phenolic glycosides with a rare β-d-glucopyranosyl-(1→3)-α-l-rhamnopyranosyl moiety (1, 2), one new dihydrobenzofuran derivative (3), one new pyrazine derivative (4), two new furofuran lignan glycosides (5, 6), and six known compounds (7-12) were isolated from the rhizomes of atractylodes lancea. the structures of these compounds were elucidated by extensive spectroscopic analyses combined with the experimental and calculated electronic circular dichroism and the rh2(ococf3)4-induced cir ... | 2016 | 27717545 |
| a novel exopolysaccharide elicitor from endophytic fungus gilmaniella sp. al12 on volatile oils accumulation in atractylodes lancea. | endophytes and plants can establish specific long-term symbiosis through the accumulation of secondary metabolites. previous studies have shown that the endophytic fungus gilmaniella sp. al12 can stimulate atractylodes lancea to produce volatile oils. the purpose of this report is to investigate key factors involved in the stimulation of a. lancea by al12 and reveal the mechanism. we identified the active component from al12 as an extracellular mannan with a polymerization degree of 26-42. diffe ... | 2016 | 27703209 |
| atractylodin inhibits interleukin-6 by blocking npm-alk activation and mapks in hmc-1. | atractylodin is one of the major constituents of the rhizome of atractylodes lancea, which is widely used in korean traditional medicine as a remedy for the treatment of gastritis and gastric ulcers. despite of a major constituent of widely used botanical to treat inflammatory responses little is known about anti-inflammatory effect of atractylodin in the human mast cell (hmc-1). hence, we evaluated the effect of atractylodin on the release of il-6, the involvement of nucleophosmin-anaplastic ly ... | 2016 | 27598116 |
| eight new eudesmane- and eremophilane-type sesquiterpenoids from atractylodes lancea. | phytochemical and pharmacological study on the rhizomes of atractylodes lancea led to the identification of twenty-one compounds: six new eudesmane-type sesquiterpenoids (1-6), two new eremophilane-type sesquiterpenoids (7, 8), and thirteen known compounds (9-21). these new compounds were elucidated using extensive spectroscopic analyses with experimental and calculated electronic circular dichroism (ecd) for the configurational assignments. notably, this study was the first report on the isolat ... | 2016 | 27592419 |
| the suppressive effects of the petroleum ether fraction from atractylodes lancea (thunb.) dc. on a collagen-induced arthritis model. | in chinese traditional medicine, the rhizome of atractylodes lancea (thunb.) dc. (a. lancea) is used extensively for the treatment of several diseases such as rheumatic diseases, but its actions on rheumatoid arthritis have not been clarified. the purpose of this article was to investigate the pharmacological effect of an a. lancea rhizome extract on collagen-induced arthritis (cia) in rats. the cia model was induced by the injection of bovine type ii collagen. the rats were orally administered ... | 2016 | 27373691 |
| bioactive sesquiterpenoid and polyacetylene glycosides from atractylodes lancea. | nine new sesquiterpenoids (1-9), five new polyacetylenes (10-14), and six known compounds were isolated from the rhizomes of atractylodes lancea. these new chemical structures were established using nmr, ms, and ecd data. notably, compounds 3-5, the aglycone of which possesses two stereogenic centers (c-5 and c-7), exhibited similar ecd spectra to compounds 1 and 2, the aglycone of which possesses one stereogenic center (c-7). such a difference was supported by the experimental and calculated ec ... | 2016 | 27228227 |
| quantitative and fingerprinting analysis of atractylodes rhizome based on gas chromatography with flame ionization detection combined with chemometrics. | this study assessed the feasibility of gas chromatography with flame ionization detection fingerprinting combined with chemometrics for quality analysis of atractylodes rhizome. we extracted essential oils from 20 atractylodes lancea and atractylodes koreana samples by hydrodistillation. the variation in extraction yields (1.33-4.06%) suggested that contents of the essential oils differed between species. the volatile components (atractylon, atractydin, and atractylenolide i, ii, and iii) were q ... | 2016 | 27133960 |
| [effects of different microhabitas on growth and four kinds of volatile oil components of atractylodes lancea]. | to investigate the suitable site environment for atractylodes lancea, field trials in different niches was carried out, and the seedling growth, biomass and volatile oil components in different microhabitas was studied. the study found that the survival rate, plant height, volatile oil content of those which growing under the bamboo were significantly higher than those exposed in the open field. the survival rate understory was (76 ± 15.1) %, plant height understory was (77 ± 14. 8) cm and the s ... | 2015 | 27071246 |
| differential gene expression between leaf and rhizome in atractylodes lancea: a comparative transcriptome analysis. | the rhizome of atractylodes lancea is extensively used in the practice of traditional chinese medicine because of its broad pharmacological activities. this study was designed to characterize the transcriptome profiling of the rhizome and leaf of atractylodes lancea in an attempt to uncover the molecular mechanisms regulating rhizome formation and growth. over 270 million clean reads were assembled into 92,366 unigenes, 58% of which are homologous with sequences in public protein databases (nr, ... | 2016 | 27066021 |
| determination and pharmacokinetic comparisons of atractylodin after oral administration of crude and processed atractylodis rhizoma. | in traditional chinese medicine, atractylodis rhizoma is the dried rhizome of atractylodes lancea (thunb.) dc. or atractylodes chinensis (dc.) koidz. after being processed, the dryness of a. rhizoma decreased, and the function of tonifying spleen increased. therefore, the processed a. rhizoma is the best choice of clinical application. as the main active components, polyethylene alkynes exhibits various desirable pharmacological effects including anti-inflammatory, anti-bacterial and anti-arrhyt ... | 2017 | 27019565 |
| the transcript profile of a traditional chinese medicine, atractylodes lancea, revealing its sesquiterpenoid biosynthesis of the major active components. | atractylodes lancea (thunb.) dc., named "cangzhu" in china, which belongs to the asteraceae family. in some countries of southeast asia (china, thailand, korea, japan etc.) its rhizome, commonly called rhizoma atractylodis, is used to treat many diseases as it contains a variety of sesquiterpenoids and other components of medicinal importance. despite its medicinal value, the information of the sesquiterpenoid biosynthesis is largely unknown. in this study, we investigated the transcriptome anal ... | 2016 | 26990438 |
| [flow cytometric analysis of genome size in atractylodes lancea]. | to develop a rapid analytical method for the determination of genome size of atractylodes lancea by flow cytometry (fcm), and to estimate genome size of five typical plant types of cultivated atractylodes lancea. | 2015 | 26762053 |
| the role of the seven crude drug components in the sleep-promoting effect of yokukansan. | yokukansan is a traditional japanese "kampo" medicine derived from yi-gan san in traditional chinese medicine. many studies have been published on its effects and mechanisms. in this study, we focused on the sleep-promoting effects of yokukansan. | 2016 | 26611914 |
| the natural compound codonolactone attenuates tgf-β1-mediated epithelial-to-mesenchymal transition and motility of breast cancer cells. | codonolactone (clt), a natural product, is the major bioactive component of atractylodes lancea, and also found in a range of other medical herbs, such as codonopsis pilosula, chloranthus henryi hemsl and atractylodes macrocephala koidz. this sesquiterpene lactone has been demonstrated to exhibit a range of activities, including anti-allergic activity, anti-inflammatory, anticancer, gastroprotective and neuroprotective activity. previously, we found that clt showed significant anti-metastatic pr ... | 2016 | 26549400 |
| [effects of lime on seedling growth,yield and volatile constituents of atractylodes lancea]. | to investigate the effects of different amounts of lime on yield and quality of atractylodes lancea, and to provide reference for the herb growing site soil improvement and self-poisoning ease. | 2015 | 26495637 |
| inhibitory activities of thai medicinal plants with promising activities against malaria and cholangiocarcinoma on human cytochrome p450. | malaria and cholangiocarcinoma remain important public health problems in tropical countries including southeast asian nations. newly developed chemotherapeutic and plant-derived drugs are urgently required for the control of both diseases. the aim of the present study was to investigate the propensity to inhibit cytochrome p450-mediated hepatic metabolism (cyp1a2, cyp2c19, cyp2d6 and cyp3a4) of the crude ethanolic extract of eight thai medicinal plants with promising activities against malaria ... | 2015 | 26490449 |
| the natural compound codonolactone impairs tumor induced angiogenesis by downregulating bmp signaling in endothelial cells. | angiogenesis, the recruitment of new blood vessels, was demonstrated that is an essential component of the growth of a tumor beyond a certain size and the metastatic pathway. the potential use of angiogenesis-based agents, such as those involving natural and synthetic inhibitors as anticancer drugs is currently under intense investigation. in this study, the anti-angiogenic properties of codonolactone (clt), a sesquiterpene lactone from atractylodes lancea, were examined in endothelial cells. | 2015 | 26407944 |
| [study on therapeutic effects of ermiao pill and ermiao pill categorized formula in hyperuricemic rats using spectroscopic methods]. | a stable mouse model of hyperuricemia was established by intraperitoneal injection of xanthine and oxonate, comparing the water extracts (containing crude drug 360 mg · ml(-1)) of ermiao pill categorized formula (the ratio of atractylodes lancea to cortex phellodendri was 1:1, 1:2 and 2:1, respectively) and ermiao pill (360 mg · ml(-1)) administered to different groups of animals continuously for two weeks and assessing the protection or treatment of drug on hyperuricemia. the xanthine oxidase ( ... | 2015 | 26197582 |
| insecticidal and repellant activities of polyacetylenes and lactones derived from atractylodes lancea rhizomes. | during a screening program for new agrochemicals from chinese medicinal herbs and local wild plants, the petroleum ether (pe) extract of atractylodes lancea (thunb.) rhizomes was found to possess repellent and contact activities against tribolium castaneum adults. bioactivity-directed chromatographic separation of pe extract on repeated silica-gel columns led to the isolation of two polyacetylenes, atractylodin and atractylodinol (1 and 2, resp.), and two lactones, atractylenolides ii and iii (3 ... | 2015 | 25879503 |
| hinesol, a compound isolated from the essential oils of atractylodes lancea rhizome, inhibits cell growth and induces apoptosis in human leukemia hl-60 cells. | hinesol is a unique sesquiterpenoid isolated from the chinese traditional medicine, atractylodes lancea rhizome. in a previous study, we screened various natural products in human leukemia hl-60 cells and identified an essential oil fraction from a. lancea rhizome that exhibited apoptosis-inducing activity in these cells; hinesol was subsequently shown to be the compound responsible for this apoptosis-inducing activity. in this study, we describe the cytotoxic effects and molecular mechanisms of ... | 2015 | 25833731 |
| the influences of inorganic elements in soil on the development of famous - region atractylodes lancea (thunb.) dc. | atractylodes lancea (thunb.) dc., is an important medicinal plant in china. recently, researches of a. lancea were focused on chemical composition and genetics, only a few were concerned with soil factors. | 2017 | 25829773 |
| effects of er-miao-san extracts on tnf-alpha-induced mmp-1 expression in human dermal fibroblasts. | various health benefits have been attributed to er-miao-san (ems), a traditional chinese herbal formulation that contains equal amounts of cortex phellodendri (phellodendron amurense ruprecht) and rhizoma atractylodis (atractylodes lancea d.c). however, its effect on the anti-inflammatory activity in human dermal fibroblasts (hdfs) and the mechanism underlying this effect are unknown. | 2015 | 25761492 |
| comparison of the anti-ulcer activity between the crude and bran-processed atractylodes lancea in the rat model of gastric ulcer induced by acetic acid. | the rhizome of atractylodes lancea (al, compositae, chinese name: cangzhu; japanese name: sou-ju-tsu) has been used traditionally for the treatment of various diseases such as digestive disorders, rheumatic diseases, and influenza in china, korea and japan. the crude al and al bran-processed are both listed in the chinese pharmacopoeia. however, the differences between the effects of the crude and al bran-processed on gastric ulcer were poorly understood, and the mechanisms for the treatment of ... | 2015 | 25481080 |
| [comprehensive chemical pattern recognition of atractylodis rhizoma]. | a method of comprehensive chemical pattern recognition of atractylodis rhizoma was established by gc-ms fingerprint, principal component analysis, cluster analysis and discriminant analysis. a db-wax column (0.25 mm x 60 m, 0.25 microm) with el ion source and 70 v electron multiplier were used for gc-ms analysis. using principal component analysis, cluster analysis, and discriminant analysis, 15 common peaks of sample fingerprints for chemical pattern recognition research were analysed. the same ... | 2014 | 25276978 |
| therapeutic potential and pharmacological activities of atractylodes lancea (thunb.) dc. | the rhizome of atractylodes lancea (a. lancea) (thunb.) dc. (al) is extensively used in chinese, thai, and japanese traditional medicines as crude extracts/decoctions or a component in various herbal formulations. various pharmacological activities of al and its major constituents have been demonstrated in vitro, ex vivo, and in animal models. results from the toxicity studies in animal models suggest safety profile of al and its active constituents. despite extensive use with positive impressio ... | 2014 | 25066389 |
| involvement of abscisic acid and salicylic acid in signal cascade regulating bacterial endophyte-induced volatile oil biosynthesis in plantlets of atractylodes lancea. | the enormous biological diversity of endophytes, coupled with their potential to enhance the production of bioactive metabolites in plants, has driven research efforts focusing on endophytes. however, limited information is available on the impacts of bacterial endophytes on plant secondary metabolism and signaling pathways involved. this work showed that an endophytic acinetobacter sp. aleb16, capable of activating accumulation of plant volatile oils, also induced abscisic acid (aba) and salicy ... | 2015 | 24862990 |
| lipase inhibition and antiobesity effect of atractylodes lancea. | the ethanol extract of atractylodes lancea rhizome displayed significant lipase inhibition with an ic50 value of 9.06 µg/ml in a human pancreatic lipase assay from high-throughput screening. bioassay-guided isolation led to the identification of one new polyacetylene, syn-(5e,11e)-3-acetoxy-4-o-(3-methylbutanoyl)-1,5,11-tridecatriene-7,9-diyne-3,4-diol (7), along with six known compounds (1-6). the structure of compound 7 was determined based on the analysis of nmr and ms data. among these seven ... | 2014 | 24687739 |
| relative determination of the alkaloid metabolites of er miao san in rat urine by lc-ms/ms and its application to pharmacokinetics. | in the present study, five metabolites of cortex phellodendri chinensis, an important herbal drug, were identified using liquid chromatography multi-stage tandem mass spectrometric techniques (lc-ms(n)). a sensitive and rapid high-performance liquid chromatographic tandem mass spectrometry (lc-ms/ms) method was developed for the quantitation of the five metabolites, utilizing chlorobenzylidine as the internal standard in rat urine. urine samples were precipitated with acetonitrile. chromatograph ... | 2014 | 24508675 |
| [authenticate of atractylodes macrocephala seed by amplification refractory mutation system]. | to design specific primers and authenticate atractylodes macrocephala from atractylodes lancea and a. chinensis. | 2013 | 24228563 |
| a valid approach in refractory glossodynia: a single-institution 5-year experience treating with japanese traditional herbal (kampo) medicine. | glossodynia is often refractory to conventional medicine, and there is only limited evidence to guide clinicians in its management. patients with refractory glossodynia are often introduced to japanese traditional herbal (kampo) medicine experts under such circumstances because kampo medicine has become known in japan to be effective in treating a wide variety of symptoms refractory to conventional medicine. herein, we report our single-institution 5-year experience treating patients with kampo ... | 2013 | 24223055 |
| effect of gambisan on the inhibition of adipogenesis in 3t3-l1 adipocytes. | this study was conducted to explore the antiadipogenic effect and possible mechanism of gambisan on 3t3-l1 cells. for quality control, gambisan was standardized by hplc and the standard compounds ephedrine, epigallocatechin-3-gallate, and caffeine were screened. cultured 3t3-l1 cells that had been induced to differentiate were treated with various concentrations of gambisan or its major component extracts (ephedra intermedia schrenk, atractylodes lancea dc., and thea sinensis l.) for 72 hours fo ... | 2013 | 24069055 |
| nitric oxide and brassinosteroids mediated fungal endophyte-induced volatile oil production through protein phosphorylation pathways in atractylodes lancea plantlets. | fungal endophytes have been isolated from almost every plant, infecting their hosts without causing visible disease symptoms, and yet have still proved to be involved in plant secondary metabolites accumulation. to decipher the possible physiological mechanisms of the endophytic fungus-host interaction, the role of protein phosphorylation and the relationship between endophytic fungus-induced kinase activity and nitric oxide (no) and brassinolide (bl) in endophyte-enhanced volatile oil accumulat ... | 2013 | 23773784 |
| selective fraction of atractylodes lancea (thunb.) dc. and its growth inhibitory effect on human gastric cancer cells. | the purpose of this study was to investigate the pharmacological effect of fraction of atractylodes lancea (thunb.) dc. (a. lancea) extract. in this study, we isolated different polarity fractions, including petroleum ether (pe), ethyl acetate, n-butanol, and the remaining h2o fractions from the water extract of a. lancea. the antigastric cancer properties of the different fractions in bgc-823 and sgc-7901 cells were evaluated. apoptotic cells were treated with pe fraction and stained with hoech ... | 2014 | 23564282 |
| molecular systematics of genus atractylodes (compositae, cardueae): evidence from internal transcribed spacer (its) and trnl-f sequences. | to determine the evolutionary relationships among all members of the genus atractylodes (compositae, cardueae), we conducted molecular phylogenetic analyses of one nuclear dna (nrdna) region (internal transcribed spacer, its) and one chloroplast dna (cpdna) region (intergenic spacer region of trnl-f). in its and its + trnl-f trees, all members of atractylodes form a monophyletic clade. atractylodes is a sister group of the carlina and atractylis branch. atractylodes species were distributed amon ... | 2012 | 23203084 |
| [pharmacodynamics of water extracts from atractylodes lancea before and after processing]. | to study the pharmacological changes of atractylodes lancea before and after processing and the processing mechanism on the basis of the pharmacological changes. | 2012 | 23189733 |
| [pollen morphological characteristics, viability test and storage of endangered medicinal plant atractylodes lancea]. | to study the pollen morphological characteristics, viability test and storage character of the endangered plant atractylodes lancea. | 2012 | 22993978 |
| jasmonic acid is involved in the signaling pathway for fungal endophyte-induced volatile oil accumulation of atractylodes lancea plantlets. | jasmonic acid (ja) is a well-characterized signaling molecule in plant defense responses. however, its relationships with other signal molecules in secondary metabolite production induced by endophytic fungus are largely unknown. atractylodes lancea (asteraceae) is a traditional chinese medicinal plant that produces antimicrobial volatiles oils. we incubated plantlets of a. lancea with the fungus gilmaniella sp. al12. to research how ja interacted with other signal molecules in volatile oil prod ... | 2012 | 22856333 |
| effects of an atractylodes lancea rhizome extract and a volatile component β-eudesmol on gastrointestinal motility in mice. | the rhizomes of atractylodes lancea dc (compositae) are used clinically to treat gastrointestinal symptoms, including functional dyspepsia and gastroparesis, in china and japan, but their influence and mechanism on gastrointestinal motility are not yet proven in detail. | 2012 | 22374082 |
| antioxidant and anti-inflammatory activities of thai medicinal plants in sahasthara remedy for muscle pain treatment. | twenty one plants as ingredients of thai traditional preparation called sahasthara for relieve muscles pain and distal numbness were studied for their antioxidant and anti-inflammatory activities. | 2012 | 23964454 |
| antioxidant and nitric oxide inhibition activities of thai medicinal plants. | nineteen thai medicinal plants used in thai traditional medicine preparation to treat colds, asthma and fever were studied for their antioxidant and no inhibitory activities. three extracts were obtained from each plant. first extract obtained by macerating the plant part in 95% ethanol (et) residue was boiled in water, where water extract (ew) was obtained. the third extract (hw) was obtained by boiling each plant in water similar to that of thai traditional medicine practice. these extracts we ... | 2010 | 21294419 |
| [determination of tractylodinol in different populations of atractylodes lancea]. | to establish an rp-hplc method for determination of atractylodinol in ateractylodes lancea and compare the contents of atractylodinol in the herbs of different origins. | 2010 | 20575380 |
| [simultaneous determination of atractylone, hinesol, beta-eudesmol, atrctylodin in atractylodes lancea and hierarchical cluster analysis]. | to develop a gc method for simultaneous determination of 4 compounds (atractylone, hinesol, beta-eudesmol and atractylodin) in atractylodes lancea. | 2010 | 20545197 |