| new species of aspergillus producing sterigmatocystin. | a number of species belonging to the genus aspergillus were evaluated for their toxicity to ducklings and the ability to produce sterigmatocystin. three new species capable of producing sterigmatocystin were found, namely, aspergillus aurantio-brunneus, aspergillus quadrilineatus, and aspergillus ustus. all three were toxic to ducklings. the production of sterigmatocystin by aspergillus rugulosus was confirmed, and the toxicity of aspergillus stellatus and aspergillus multicolor is described. | 1977 | 406838 |
| austin, a novel polyisoprenoid mycotoxin from aspergillus ustus. | | 1976 | 972231 |
| austocystins. six novel dihydrofuro (3',2':4,5)furo(3,2-b)xanthenones from aspergillus ustus. | | 1974 | 4475678 |
| cure of aspergillus ustus endocarditis on a prosthetic valve. | | 1974 | 4811488 |
| constitution and absolute configuration of austdiol, the main toxic metabolite from aspergillus ustus. | | 1974 | 4856117 |
| [hydrolysis of streptococcal polysaccharides by micromycete dextranases]. | the effect of dextranase enzyme preparations obtained from penicillium piscarium bim g-102, penicillium funiculosum, aspergillus insuetus g-116 and aspergillus ustus on polysaccharides synthesized by cariesogenic streptococcus sanguis and streptococcus mitis was being studied. according to the data obtained dextranases from p. piscarium, p. funiculosum and asp. ustus can be considered as a promising anticarious agent. | 1984 | 6540443 |
| primary cutaneous aspergillus ustus infection: second reported case. | we describe the second case of primary cutaneous aspergillus ustus infection in an immunocompromised patient. cutaneous aspergillosis was confirmed both by culture and positive fluorescent antibody staining. few species of aspergillus are pathogenic in human beings, and fewer still cause primary cutaneous disease. the only other reported case of aspergillosis from aspergillus ustus occurred in an immunosuppressed patient who was temporally and geographically separated from ours. | 1998 | 9591788 |
| disseminated aspergillosis caused by aspergillus ustus in a patient following allogeneic peripheral stem cell transplantation. | the first case of disseminated aspergillosis caused by aspergillus ustus in an allogeneic peripheral stem cell transplant patient is described. the patient, a 46-year-old female with a history of myelodysplastic syndrome, underwent high-dose chemotherapy and total body irradiation prior to transplantation. she was released from the hospital 49 days posttransplant (p.t.) in a stable condition with an absolute neutrophil count (anc) of 2,700 cells per microl. multiple antimicrobial agents, includi ... | 1998 | 9817905 |
| invasive aspergillosis caused by aspergillus ustus: case report and review. | a case of invasive pulmonary aspergillosis in an allogeneic bone marrow transplant recipient caused by aspergillus ustus is presented. a. ustus was also recovered from the hospital environment, which may indicate that the infection was nosocomially acquired. a literature review revealed seven cases of invasive infections caused by a. ustus, and three of these were primarily cutaneous infections. in vitro susceptibility testing of 12 a. ustus isolates showed that amphotericin b and terbinafine ha ... | 1999 | 10203536 |
| antitumor activity of phenylahistin in vitro and in vivo. | phenylahistin is a new cell cycle inhibitor produced by aspergillus ustus. since phenylahistin was produced as a scalemic mixture of (-)-phenylahistin and its enantiomer, we separated each enantiomer and evaluated their antitumor activity in vitro. (-)-phenylahistin exhibited antitumor activity against 8 tumor cell lines with ic50 values ranging from 1.8 x 10(-7) to 3.7 x 10(-6), while (+)-phenylahistin exhibited 33-100-fold less potent activity than (-)-phenylahistin did. (-)-phenylahistin also ... | 1999 | 10427703 |
| colorimetric assay for antifungal susceptibility testing of aspergillus species. | a colorimetric assay for antifungal susceptibility testing of aspergillus species (aspergillus fumigatus, aspergillus flavus, aspergillus terreus, aspergillus nidulans, and aspergillus ustus) is described based on the reduction of the tetrazolium salt 2,3-bis(2-methoxy-4-nitro-5-[(sulphenylamino)carbonyl]-2h-tetrazolium-hydroxide (xtt) in the presence of menadione as an electron-coupling agent. the combination of 200 microg of xtt/ml with 25 microm menadione resulted in a high production of form ... | 2001 | 11526191 |
| diversity in soil fungi from undisturbed and disturbed celtis tala and scutia buxifolia forests in the eastern buenos aires province (argentina). | the rhizospheric soil microfungi from a native forest (undisturbed and disturbed) were studied using soil dilution plate and soil washing methods. fungi were isolated using slightly acid and alkaline culture media. 54 taxa were isolated: 49 from undisturbed forest soil and 37 from disturbed forest soil. acremonium sp., aspergillus ustus, coemansia pectinata, doratomyces stemonitis, fusarium solani, f. oxysporum, gliocladium roseum, humicola fusco-atra, mortierella sp., penicillium lilacinum, tri ... | 2002 | 12002400 |
| differentiation of aspergillus ustus strains by random amplification of polymorphic dna. | the sodium dodecyl sulfate-polyacrylamide gel electrophoresis patterns of water-soluble proteins and the randomly amplified polymorphic dna (rapd) patterns of whole-cell lysates from 21 aspergillus ustus isolates, including 11 reference strains and 10 patient and environmental strains from one hospital, were investigated. all isolates showed identical protein patterns. the rapd assay discriminated between all reference strains. comparison of hospital isolates showed identical rapd patterns in so ... | 2002 | 12037094 |
| cellular responses to environmental salinity in the halophilic black yeast hortaea werneckii. | the development of crop plants with increased salt tolerance necessitates the study of naturally salt-tolerant eukaryotic species. we studied the bio-synthesis of glycerol as a compatible solute in the halophilic eukaryotic microorganism, black yeast hortaea werneckii. a restriction fragment-differential display technique was used to investigate the transcriptome of the organism. eight differentially expressed genes were identified in response to growth at different salinities. although the puta ... | 2002 | 12139614 |
| faster genetic identification of medically important aspergilli by using gellan gum as gelling agent in mycological media. | using gellan gum as a substitute for agar-agar in a mycological medium and sequencing of the its 1 and 2 regions resulted in an accurate identification of aspergillus fumigatus, aspergillus nidulans, aspergillus terreus and aspergillus ustus within 24 h of subculture. | 2003 | 12867558 |
| studies in the biochemistry of micro-organisms; ustic acid, a metabolic product of aspergillus ustus (bainier) thom & church. | | 1951 | 14820785 |
| rapid differentiation of aspergillus species from other medically important opportunistic molds and yeasts by pcr-enzyme immunoassay. | we developed a pcr-based assay to differentiate medically important species of aspergillus from one another and from other opportunistic molds and yeasts by employing universal, fungus-specific primers and dna probes in an enzyme immunoassay format (pcr-eia). oligonucleotide probes, directed to the internal transcribed spacer 2 region of ribosomal dna from aspergillus flavus, aspergillus fumigatus, aspergillus nidulans, aspergillus niger, aspergillus terreus, aspergillus ustus, and aspergillus v ... | 2004 | 15297489 |
| use of lung resection and voriconazole for successful treatment of invasive pulmonary aspergillus ustus infection. | invasive pulmonary aspergillosis (ipa) is a common infection in neutropenic patients and is associated with high mortality. aspergillus ustus is a species that has only rarely been implicated in human disease. all reported cases of ipa due to a. ustus have been fatal. here, we describe a case of invasive pulmonary a. ustus infection successfully treated with lung resection and voriconazole. a 43-year-old man with acute myeloid leukemia underwent two courses of chemotherapy and experienced prolon ... | 2004 | 15472346 |
| assessment of ribosomal large-subunit d1-d2, internal transcribed spacer 1, and internal transcribed spacer 2 regions as targets for molecular identification of medically important aspergillus species. | molecular approaches are now being developed to provide a more rapid and objective identification of fungi compared to traditional phenotypic methods. ribosomal targets, especially the large-subunit rna gene (d1-d2 region) and internal transcribed spacers 1 and 2 (its1 and its2 regions), have shown particular promise for the molecular identification of some fungi. we therefore conducted an assessment of these regions for the identification of 13 medically important aspergillus species: aspergill ... | 2005 | 15872227 |
| breakthrough disseminated aspergillus ustus infection in allogeneic hematopoietic stem cell transplant recipients receiving voriconazole or caspofungin prophylaxis. | aspergillus ustus is an uncommon clinical species which is poorly susceptible to antifungals. we report two cases of a. ustus infections that occurred in allogeneic stem cell transplant recipients while they were receiving either voriconazole or caspofungin. prolonged use of these new antifungal agents may increase the risk of the emergence of resistant organisms. | 2005 | 16145172 |
| aspergillus ustus infections among transplant recipients. | aspergillus ustus is a mold that rarely infects humans; only 15 systemic cases have been reported. we report the first outbreak of invasive infection caused by a. ustus among hematopoietic stem cell transplant (hsct) recipients. six patients with infections were identified; 3 infections each occurred in both 2001 and 2003. molecular typing by using randomly amplified polymorphic dna (rapd) and antifungal drug susceptibility testing were performed on clinical and environmental isolates recovered ... | 2006 | 16704776 |
| clustering of invasive aspergillus ustus eye infections in a tertiary care hospital: a molecular epidemiologic study of an uncommon species. | aspergillus infections are being increasingly recognized as an important cause of morbidity and blindness. we report here the first cluster of aspergillus ustus endophthalmitis cases which occurred in a large tertiary care hospital during the period october 2003 to june 2004. in three of the cases, the patients required enucleation following cataract surgery, while the fourth involved a fatal infection in a pediatric patient hospitalized for osteopetrosis. patient charts from the four cases were ... | 2007 | 17510862 |
| aspergillus ustus. | | 1945 | 17736118 |
| a metabolic product of aspergillus ustus (bainier) thom & church. | | 1949 | 18145276 |
| successful treatment of primary cutaneous aspergillus ustus infection with surgical debridement and a combination of voriconazole and terbinafine. | aspergillus ustus infections are associated with a high mortality in immunocompromised hosts, and the mold has decreased susceptibility to most antifungal drugs, especially azoles. we report primary cutaneous a. ustus infection in a patient who failed itraconazole therapy and was switched to voriconazole (vrc). during vrc therapy, the mics of vrc, amphotericin b (amb), caspofungin (cfg), and terbinafine (tbf) were 4, 2, 64, and 0.13 microg/ml, respectively. because the mic to vrc was high, tbf w ... | 2008 | 18842377 |
| secondary metabolites from eurotium species, aspergillus calidoustus and a. insuetus common in canadian homes with a review of their chemistry and biological activities. | as part of studies of metabolites from fungi common in the built environment in canadian homes, we investigated metabolites from strains of three eurotium species, namely e. herbariorum, e. amstelodami, and e. rubrum as well as a number of isolates provisionally identified as aspergillus ustus. the latter have been recently assigned as the new species a. insuetus and a. calidoustus. e. amstelodami produced neoechinulin a and neoechinulin b, epiheveadride, flavoglaucin, auroglaucin, and isotetrah ... | 2009 | 19422073 |
| identification by distribution studies; isolation of antibiotic principles from aspergillus ustus. | | 1946 | 21020879 |
| metabolic products of aspergillus ustus. | | 1946 | 21022264 |
| removal of humic substances by biosorption. | fungal pellets of aspergillus niger 405, aspergillus ustus 326, and stachybotrys sp. 1103 were used for the removal of humic substances from aqueous solutions. batchwise biosorption, carried out at ph 6 and 25 degrees c, was monitored spectrophotometrically and the process described with freundlich's model. calculated sorption coefficients k(f) and n showed that a. niger exhibited the highest efficiency. a good match between the model and experimental data and a high correlation coefficient (r2) ... | 2008 | 19209626 |
| drimane sesquiterpenoids from the mangrove-derived fungus aspergillus ustus. | five new drimane sesquiterpenes (1-5) together with 14 known analogues (6-19) were isolated from laboratory cultures of a mangrove-derived fungus aspergillus ustus. their structures were established by spectroscopic methods and antitumor activities were evaluated by sulforhodamine b (srb) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) methods. | 2011 | 21628915 |
| cerebral aspergillosis caused by aspergillus ustus following orthotopic heart transplantation: case report and review of the literature. | this report describes the first case of cerebral aspergillosis in a heart transplantation patient caused by aspergillus ustus and reviews 15 previously reported cases of invasive aspergillosis in immunocompromised hosts caused by this mold. the utility of molecular analysis for the identification of unusual fungal pathogens is also described. the refractory nature of a. ustus to treatment is similar to other aspergillus species and treatment options are reviewed. | 2009 | 18798849 |
| New taxa in Aspergillus section Usti. | Based on phylogenetic analysis of sequence data, Aspergillus section Usti includes 21 species, inclucing two teleomorphic species Aspergillus heterothallicus (= Emericella heterothallica) and Fennellia monodii. Aspergillus germanicus sp. nov. was isolated from indoor air in Germany. This species has identical ITS sequences with A. insuetusCBS 119.27, but is clearly distinct from that species based on ß-tubulin and calmodulin sequence data. This species is unable to grow at 37 °C, similarly to A. ... | 2011 | 21892244 |
| polyphasic taxonomy of aspergillus section usti. | aspergillus ustus is a very common species in foods, soil and indoor environments. based on chemical, molecular and morphological data, a. insuetus is separated from a. ustus and revived. a. insuetus differs from a. ustus in producing drimans and ophiobolin g and h and not producing ustic acid and austocystins. the molecular, physiological and morphological data also indicated that another species, a. keveiisp. nov. is closely related but distinct from a. insuetus. aspergillus section usti sensu ... | 2007 | 18490949 |
| aspergillus calidoustus sp. nov., causative agent of human infections previously assigned to aspergillus ustus. | aspergillus ustus is a relatively rare human pathogen causing invasive infections in immunocompromised hosts. in this study isolates originating from clinical and other sources have been examined using molecular, morphological, and physiological approaches to clarify their species assignment. phylogenetic analysis of partial beta-tubulin, calmodulin, actin, and intergenic transcribed spacer sequences indicated that none of the clinical isolates recognized previously as a. ustus belongs to this s ... | 2008 | 18281596 |
| cutaneous aspergillus ustus in a lung transplant recipient: emergence of a new opportunistic fungal pathogen. | opportunistic fungal infections remain a significant complication in immunosuppressed patients, especially those having undergone solid-organ transplantation. we report a 39-year-old patient who represents the second case of cutaneous aspergillus ustus infection in a solid-organ transplant recipient, and the first documented case after lung transplantation. the patient's cutaneous lower extremity aspergillosis responded to a combination of intravenous liposomal amphotericin b, caspofungin and to ... | 2008 | 18187099 |
| primary cutaneous aspergillosis due to aspergillus tamarii in an immunocompetent host. | primary cutaneous aspergillosis is a rare disease usually caused by aspergillus fumigatus, aspergillus flavus, aspergillus terreus and aspergillus ustus. it is usually seen in immunocompromised hosts, though some cases are also reported in immunocompetent hosts. we present a case of an immunocompetent farmer who presented with generalised nodules and plaques, mimicking erythema nodosum leprosum but turned out to be cutaneous aspergillosis caused by aspergillus tamarii. the characteristic ascospo ... | 2013 | 23970496 |
| generation and characterization of indoor fungal aerosols for inhalation studies. | in the indoor environment, people are exposed to several fungal species. evident dampness is associated with increased respiratory symptoms. to examine the immune responses associated with fungal exposure, mice are often exposed to a single species grown on an agar medium. the aim of this study was to develop an inhalation exposure system to be able to examine responses in mice exposed to mixed fungal species aerosolized from fungus-infested building materials. indoor airborne fungi were sampled ... | 2016 | 26921421 |
| fungal endophthalmitis caused by aspergillus ustus in a patient following cataract surgery. | the first case of postoperative endophthalmitis after cataract surgery caused by aspergillus ustus, a species that has only rarely been implicated in human disease, is described. six weeks after cataract surgery, a 67-year-old medically controlled diabetic patient presented with uveitis, mild ciliary injection and ocular discomfort. anterior chamber paracentesis, vitreous tap and finally complete vitrectomy with removal of the capsular bag including the intraocular lens were performed and severa ... | 2006 | 17071563 |
| tropical soil microflora of spice-based cropping systems as potential antagonists of root-knot nematodes. | suppression of plant parasitic nematodes with nematode predators, parasites or antagonists is an eco-friendly approach than the toxic chemicals. in a study, soil borne fungi from the rhizosphere of major spice crops were collected from diverse cropping systems prevailing in three southern states of india. a series of in vitro studies were conducted using 73 freshly collected fungal isolates and 76 isolates obtained from other sources. out of this 67 isolates were not parasitic on females of root ... | 2005 | 15955340 |
| synthesis of the new furo[3,2-h]isoquinoline alkaloid, tmc-120b from aspergillus ustus. | a total synthesis of a new furo[3,2-h]isoquinoline alkaloid tmc120-b (2), isolated from aspergillus ustus together with two related compounds, has been completed in sixteen steps. the key step is the synthesis of the appropriate 3,7,8-trisubstituted isoquinoline framework (23) based on a thermal electrocyclic reaction of the 1-aza 6pi-electron system involving the benzene double bond. in addition, the microwave assisted electrocyclic reaction of this system was newly performed. | 2005 | 15802838 |
| primary cutaneous aspergillosis caused by aspergillus ustus following reduced-intensity stem cell transplantation. | a 19-year-old woman with myelodysplastic syndrome underwent reduced-intensity stem cell transplantation [rist: (cladribine 0.11 mg/kg for 6 days, busulfan 4 mg/kg for 2 days, and rabbit antithymocyte globulin)] from her one hla-mismatched mother. prophylaxis against graft-versus-host disease (gvhd) was performed with cyclosporine a (csa) alone. severe acute gvhd in the skin, gut, and liver developed concurrently with stable engraftment, and methylprednisolone was administered (1-2 mg/kg per day, ... | 2002 | 12424542 |
| isolation and classification of fungal whitefly entomopathogens from soils of qinghai-tibet plateau and gansu corridor in china. | qinghai-tibet plateau and gansu corridor of china with distinct geographic and climatic conditions are remote and less disturbed by humans, in which are likely to find some new strains of fungal entomopathogens against b-biotype whiteflies that is a very important invading pest worldwide. in this research, nineteen strains among six species of entomogenous fungi were isolated from the soil samples collected from 32 locations in qinghai-tibet plateau and gansu corridor. from the data of isolation ... | 2016 | 27228109 |
| new isochromane derivatives from the mangrove fungus aspergillus ustus 094102. | four new isochromane derivatives (1-4) along with the known peniciphenol (5) and (r)-2-(hydroxymethyl)-3-(2-hydroxypropyl)pheno (6) were isolated from the etoac extract of the fermentation broth of the mangrove fungus, aspergillus ustus 094102. the structures of the new compounds including the absolute configuration were elucidated on the basis of spectroscopic analysis, cd and ecd calculation. compounds 1 and 2 exhibited α-glucosidase inhibition and anti-oxidation against dpph radical with ic50 ... | 2015 | 26882680 |
| a genomics based discovery of secondary metabolite biosynthetic gene clusters in aspergillus ustus. | secondary metabolites (sms) produced by aspergillus have been extensively studied for their crucial roles in human health, medicine and industrial production. however, the resulting information is almost exclusively derived from a few model organisms, including a. nidulans and a. fumigatus, but little is known about rare pathogens. in this study, we performed a genomics based discovery of sm biosynthetic gene clusters in aspergillus ustus, a rare human pathogen. a total of 52 gene clusters were ... | 2015 | 25706180 |
| ophiobolin o isolated from aspergillus ustus induces g1 arrest of mcf-7 cells through interaction with akt/gsk3β/cyclin d1 signaling. | ophiobolin o is a member of ophiobolin family, which has been proved to be a potent anti-tumor drug candidate for human breast cancer. however, the anti-tumor effect and the mechanism of ophiobolin o remain unclear. in this study, we further verified ophiobolin o-induced g1 phase arrest in human breast cancer mcf-7 cells, and found that ophiobolin o reduced the phosphorylation level of akt and gsk3β, and induced down-regulation of cyclin d1. the inverse docking (invdock) analysis indicated that ... | 2015 | 25603341 |
| the complete mitochondrial genome of a rare human pathogen, aspergillus ustus. | aspergillus ustus is among the most ubiquitous soil species and has been implicated in human infections. the complete mitochondrial genome of a. ustus has been determined by high-throughput sequencing technology in this work. our study revealed that the mitochondrial genome of a. ustus is 33,007 bp long, with at content of 74.84%, which consists of a usual set of mitochondrial proteins and rna genes, including large and small ribosomal rnas, 15 proteins and 20 trna genes and contains two introns ... | 2016 | 25484170 |
| cutaneous infection caused by aspergillus ustus, an emerging opportunistic fungus in immunosuppressed patients. | we report a case of primary cutaneous infection by the emerging fungus aspergillus ustus in an immunosuppressed patient after a domestic accident. the patient failed to respond to itraconazole and died before receiving a new treatment with amphotericin b. there have been eight other cases reported since 1973, and only two patients survived the infection. in vitro susceptibility testing of seven antifungal drugs showed that terbinafine and the new azole derivative ur-9825 were the most active aga ... | 2001 | 11230441 |
| production, isolation and biological properties of tmc-120a, b and c, novel inhibitors of eosinophil survival from aspergillus ustus tc 1118. | | 1999 | 10604762 |
| production of mycotoxins on artificially and naturally infested building materials. | in this study, the ability to produce mycotoxins during growth on artificially infested building materials was investigated for penicillium chrysogenum, pen. polonicum, pen. brevicompactum, chaetomium spp., aspergillus ustus, asp. niger, ulocladium spp., alternaria spp., and paecilomyces spp., all isolated from water-damaged building materials. spores from the different isolates of the above mentioned species were inoculated on gypsum board with and without wallpaper and on chipboard with and wi ... | 1999 | 10560628 |
| aspergillus baeticus sp. nov. and aspergillus thesauricus sp. nov., two species in section usti from spanish caves. | two novel species of aspergillus that are clearly distinct from all known species in section usti were revealed during a study of microfungal communities in spanish caves. the novel species identified in this study and additional species of aspergillus section usti are associated with places and substrates related to human activities in caves. novel species are described using data from four loci (its, bena, cam and rpb2), morphology and basic chemical and physiological analyses. members of the ... | 2012 | 22505602 |
| aspergillus calidoustus case series and review of the literature. | aspergillus calidoustus, previously classified as aspergillus ustus, is an emerging pathogen in immunocompromised persons. we describe four recent cases of a. calidoustus and review 37 additional cases of a. calidoustus (n=16) or a. ustus (n=25) published through june 2016. twenty (49%) cases occurred in patients with hematologic malignancy and/or receipt of hematopoietic cell transplantation, and 13 (32%) occurred in solid organ transplant recipients. antifungal susceptibility was reported in 4 ... | 2017 | 28741738 |
| antifungal susceptibility testing of aspergillus spp. by using a composite correlation index (cci)-based matrix-assisted laser desorption ionization-time of flight mass spectrometry method appears to not offer benefit over traditional broth microdilution testing. | aspergillus spp. cause serious invasive lung infections, and aspergillus fumigatus is the most commonly encountered clinically significant species. voriconazole is considered to be the drug of choice for treating a. fumigatus infections; however, rising resistance rates have been reported. we evaluated a matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof ms)-based method for the differentiation between wild-type and non-wild-type isolates of 20 aspergillus sp ... | 2017 | 28404678 |
| implication of tryptophan and histidine in the active site of endo-polygalacturonase from aspergillus ustus: elucidation of the reaction mechanism. | the mechanism of action for the hydrolysis of polygalacturonic acid by the enzyme endo-polygalacturonase (poly(1,4-alpha-d-galacturonide) glycanohydrolase, ec 3.2.1.15) was investigated. the enzyme from aspergillus ustus was purified to homogeneity and used for the study. the endo-polygalacturonase had a molecular weight of 36,000 daltons, a pi of 8.3, specific activity of 785 units/mg, km of 0.82 mg/ml, and vmax of 976 micromoles of product min-1 mg-1. amino acids involved in the catalysis were ... | 1996 | 8814223 |
| novel drimane sesquiterpene esters from aspergillus ustus var. pseudodeflectus with endothelin receptor binding activity. | a series of novel drimane sesquiterpene esters (1-6) was isolated from fermentations of aspergillus ustus var. pseudodeflectus and their structures elucidated by spectroscopic methods including the hmqc, hmbc and inadequate nmr experiments. the major component of the fermentation, 1, was (2'e,4'e,6'e)-6-(1'-carboxy-2',4',6'-trien)-9-hydroxydrim-7-ene-11 ,12-olide. compounds 1, 2, 3 and 5 exhibited endothelin receptor binding inhibitory activity against rabbit endothelin-a and rat endothelin-b re ... | 1996 | 8698631 |
| primary cutaneous infection by aspergillus ustus in a 62-year-old liver transplant recipient. | we report the first case of primary cutaneous aspergillosis caused by aspergillus ustus, a species that seldom infects human beings. the patient, a 62-year-old liver transplant recipient with end-stage hepatitis c-induced cirrhosis, was receiving the experimental immunosuppressive drug fk-506. trauma to the skin of the right arm from tape and from an arm board holding intravenous and intraarterial catheters in place and to the left leg from an occlusive knee brace may have contributed to this un ... | 1994 | 8034802 |
| disseminated aspergillus ustus infection following cardiac surgery. | aspergillus ustus is a soil residing fungus that rarely has been implicated in human infections. a 72-year-old man who had undergone surgery for mitral valve replacement and triple coronary artery bypass developed progressive pneumonia with a. ustus. the infection had spread to other organs and finally was diagnosed at postmortem examination. | 1983 | 6603788 |
| formation of diketopiperazines by penicillium italicum isolated from oranges. | prolyl-2-(1',1'-dimethylallyl)tryptophyldiketopiperazine and 12,13-dehydroprolyl-2-(1',1'-dimethylallyl)tryptophyldiketopiperazine, known metabolites of aspergillus ustus, were produced in low yield by penicillium italicum in liquid culture and on unsterilized orange peel. | 1974 | 4441068 |
| mutagenic activity of austocystins--secondary metabolites of aspergillus ustus. | | 1986 | 3779147 |
| emerging pathogen aspergillus calidoustus colonizes water distribution systems. | recent studies have changed the taxonomy of aspergillus section usti, and a novel species, aspergillus calidoustus, has been erected. it was also demonstrated that clinical isolates previously identified as a. ustus actually belong to the emerging pathogen a. calidoustus. aspergillus ustus were frequently isolated from norwegian water systems, and due to the taxonomical progress, these waterborne strains could be identified more precisely. a mlst study including its, calmodulin, β-tubulin and ac ... | 2011 | 21208025 |
| concomitant pulmonary infection with nocardia transvalensis and aspergillus ustus in lung transplantation. | lung infections with nocardia and aspergillus spp in lung transplant recipients (ltrs) create diagnostic and therapeutic challenges. the present case illustrates the difficulties in identifying these pathogens in ltrs. a high degree of clinical suspicion and aggressive early management are required to ensure good outcomes. although prospective data on treating these conditions are scarce, the empiric use of combination broad-spectrum anti-microbials initially seems prudent. | 2010 | 20541440 |
| isolation and taxonomy of filamentous fungi in endodontic infections. | the purpose of this study was to research the presence of filamentous fungi in the root canals of teeth with pulp necrosis and periapical lesions and to perform the taxonomic study of the isolates. | 2010 | 20307734 |
| drimane sesquiterpenoids from the fungus aspergillus ustus isolated from the marine sponge suberites domuncula. | seven new drimane sesquiterpenoids (1-3, 6-9), along with the known compounds deoxyuvidin b (4), strobilactone b (5), and res-1149-2 (10), were obtained from cultures of the fungus aspergillus ustus, which was isolated from the marine sponge suberites domuncula. their structures were established by means of spectroscopic analyses including one- and two-dimensional nmr spectroscopy and high-resolution ms. compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, includ ... | 2009 | 19778087 |
| sesquiterpenoids and benzofuranoids from the marine-derived fungus aspergillus ustus 094102. | eight drimane sesquiterpenes (1-8), six isochromane derivatives (9-14), and three known compounds, daldinin b (15), 9alpha-hydroxy-6beta-[(2e,4e,6e)-octa-2,4,6-trienoyloxy]-5alpha-drim-7-en-11,12-olide (16), and pergillin (17), were isolated from the etoac extract of the marine-derived fungus aspergillus ustus 094102. the structures of the new compounds were elucidated on the basis of spectroscopic analysis. the cytotoxic effects on a549 and hl-60 cell lines were evaluated by srb and mtt methods ... | 2009 | 19769341 |
| the plant growth-promoting fungus aspergillus ustus promotes growth and induces resistance against different lifestyle pathogens in arabidopsis thaliana. | to deal with pathogens, plants have evolved sophisticated mechanisms including constitutive and induced defense mechanisms. phytohormones play important roles in plant growth and development, as well as in the systemic response induced by beneficial and pathogen microorganisms. in this work, we identified an aspergillus ustus isolate that promotes growth and induces developmental changes in solanum tuberosum and arabidopsis thaliana. a. ustus inoculation on a. thaliana and s. tuberosum roots ind ... | 2011 | 21791954 |
| optimization and production of a biosurfactant from the sponge-associated marine fungus aspergillus ustus msf3. | marine endosymbiotic fungi aspergillus ustus (msf3) which produce high yield of biosurfactant was isolated from the marine sponge fasciospongia cavernosa collected from the peninsular coast of india. maximum production of biosurfactant was obtained in sabouraud dextrose broth. the optimized bioprocess conditions for the maximum production was ph 7.0, temperature 20 degrees c, salt concentration 3%, glucose and yeast extract as carbon source and nitrogen sources respectively. the response surface ... | 2009 | 19570659 |
| invasive aspergillosis of the hand caused by aspergillus ustus: a case report. | this is a case report of a 61-year-old cardiac transplant patient who developed a disseminated infection involving the upper extremity with a rare fungus known as aspergillus ustus. the patient was successfully treated with aggressive serial debridements, antifungal medications, and reduction of immunosuppression. with these interventions, the patient avoided amputation despite the aggressive nature of this infection. | 2009 | 19568818 |
| cytotoxicity of aspergillus fungi isolated from hospital environment. | the majority of mycotoxins produced by aspergillus fungi are immunosuppressive agents, and their cytotoxicity may impair defense mechanisms in humans. the objective of the study was evaluation of the cytotoxicity of fungi isolated from an environment where inpatients with impaired immunity were present. the materials comprised 57 fungal strains: aspergillus fumigatus, aspergillus niger: aspergillus ochraceus, aspergillus flavus, aspergillus versicolor and aspergillus ustus isolated from hospital ... | 2011 | 21630575 |
| influence of various growth parameters on fungal growth and volatile metabolite production by indoor molds. | a penicillium polonicum, an aspergillus ustus and a periconia britannica strain were isolated from water-damaged environments and the production of microbial volatile organic compounds (mvocs) was investigated by means of headspace solid-phase microextraction followed by gc-ms analysis. the most important mvocs produced were 2-methylisoborneol, geosmin and daucane-type sesquiterpenes for p. polonicum, 1-octen-3-ol, 3-octanone, germacrene d, δ-cadinene and other sesquiterpenes for a. ustus and th ... | 2011 | 22169393 |
| the novel agent ophiobolin o induces apoptosis and cell cycle arrest of mcf-7 cells through activation of mapk signaling pathways. | ophiobolin o is a natural compound that has been isolated from aspergillus ustus 094102. this is the first study to demonstrate the anti-proliferative effect of ophiobolin o in human breast cancer mcf-7 cells. the results of present study show that ophiobolin o induced cycle g(0)/g(1) phase arrest in mcf-7 cells using a cell cycle analysis. in addition, we demonstrated that ophiobolin o reduced the viability of human breast cancer mcf-7 cells in a time- and dose-dependent manner and efficiently ... | 2012 | 22130129 |
| identification of volatile markers for indoor fungal growth and chemotaxonomic classification of aspergillus species. | microbial volatile organic compounds (mvocs) were collected in water-damaged buildings to evaluate their use as possible indicators of indoor fungal growth. fungal species isolated from contaminated buildings were screened for mvoc production on malt extract agar by means of headspace solid-phase microextraction followed by gas chromatography-mass spectrometry (gc-ms) analysis. some sesquiterpenes, specifically derived from fungal growth, were detected in the sampled environments and the corresp ... | 2012 | 22954337 |
| antifungal activity of compounds targeting the hsp90-calcineurin pathway against various mould species. | invasive mould infections are associated with a high mortality rate and the emergence of mdr moulds is of particular concern. calcineurin and its chaperone, the heat shock protein 90 (hsp90), represent an important pathway for fungal virulence that can be targeted at different levels. we investigated the antifungal activity of compounds directly or indirectly targeting the hsp90-calcineurin axis against different mould species. | 2015 | 25558076 |
| isolation and characterization of three fungi with the potential of transforming glycyrrhizin. | three fungi with different types of transformation of glycyrrhizin (gl) were isolated from the soil samples of glycyrrhiza glabra planting area in china. according to their morphologies and 18 s rdna gene sequence analysis, the three fungi were identified and named as penicillium purpurogenum li-3, aspergillus terreus li-20 and aspergillus ustus li-62. transforming products analysis by tlc and hplc-ms indicated that p. purpurogenum li-3, a. terreus li-20 and a. ustus li-62 could stably transform ... | 2013 | 23247917 |
| molecular identification of unusual mycetoma agents isolated from patients in venezuela. | mycetoma is a chronic granulomatous, subcutaneous disease endemic in tropical and subtropical countries. it is currently a health problem in rural areas of africa, asia and south america. nine cases of mycetoma were analysed in a retrospective study. all isolates were identified by morphological features. the level of species identification was reached by molecular tools. definitive identification of fungi was performed using sequence analysis of the its of the ribosomal dna region and the ribos ... | 2017 | 27766680 |
| sesterterpene ophiobolin biosynthesis involving multiple gene clusters in aspergillus ustus. | terpenoids are the most diverse and abundant natural products among which sesterterpenes account for less than 2%, with very few reports on their biosynthesis. ophiobolins are tricyclic 5-8-5 ring sesterterpenes with potential pharmaceutical application. aspergillus ustus 094102 from mangrove rizhosphere produces ophiobolin and other terpenes. we obtained five gene cluster knockout mutants, with altered ophiobolin yield using genome sequencing and in silico analysis, combined with in vivo geneti ... | 2016 | 27273151 |
| ergosteroid derivatives from an algicolous strain of aspergillus ustus. | one new ergosteroid derivative, isocyathisterol (1), and eight known compounds (2-9) were isolated from the culture of an algicolous strain (cf-42) of aspergillus ustus obtained from the fresh tissue of marine green alga codium fragile. the structure and absolute configuration of 1 were unequivocally identified by using nmr and mass spectroscopic methods as well as quantum chemical calculations. compound 1 exhibited weak antibacterial activity. | 2014 | 24896666 |
| synthesis, structure, and cytotoxicity studies of some fungal isochromanes. | ustusorane d and penicisochromans b-d are natural isochromans isolated from aspergillus ustus 094102 and penicillium sp. psu-f40, respectively. herein, we report the syntheses of (-)-ustusorane d and (+)-penicisochroman b and the structures of penicisochromans c and d. the relative configuration of natural ustusorane d and the absolute configuration of natural penicisochroman b were determined. two plausible structures for penicisochroman c were evaluated through synthesis, but their ¹h and ¹³c ... | 2013 | 24033077 |
| clinical utility of a panfungal polymerase chain reaction assay for invasive fungal diseases in patients with haematologic disorders. | invasive fungal diseases (ifds) are life-threatening events in patients with haematologic disorders, and the spectrum of the aetiological pathogens continues to expand. this study aimed to evaluate the clinical utility of a panfungal polymerase chain reaction (pcr) assay for the management of ifds in such patients. | 2013 | 23360173 |
| changing epidemiology of invasive mold infections in patients receiving azole prophylaxis. | breakthrough invasive mold infections (imis) that occur during posaconazole or voriconazole prophylaxis are rare complications for which epidemiological data are lacking. this retrospective analysis comparing 24 microbiologically documented breakthrough with 66 nonbreakthrough imis shows a shift towards non-aspergillus molds with a significantly increased proportion of rare multidrug-resistant molds. | 2017 | 28199491 |