| folipastatin, a new depsidone compound from aspergillus unguis as an inhibitor of phospholipase a2. taxonomy, fermentation, isolation, structure determination and biological properties. | a new inhibitor of phospholipase a2 was isolated from the fermentation broth of aspergillus unguis. the structure, with a depsidone carbon skeleton, was assigned by spectroscopic experiments. | 1992 | 1399838 |
| induced production of lavendar mutants of aspergillus unguis by 5-fluorouracil. | | 1972 | 4679431 |
| induced production of cleistothecia in aspergillus unguis. | | 1971 | 5556468 |
| microbial conversion products of leptomycin b. | leptomycin b (lmb), a secondary metabolite produced by streptomyces sp. strain ats 1287, with known antifungal and antitumor effects, inhibits the nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 regulatory protein rev and exhibits significant antiproliferative activity. since lmb itself turned out to be distinctly cytotoxic, a bioconversion screening with a selected set of 29 bacterial and 72 fungal strains was performed in order to obtain metabolites of lmb with redu ... | 1998 | 9464413 |
| higher environmental relative moldiness index (ermism) values measured in detroit homes of severely asthmatic children. | sieved vacuum bag dust from the homes of 143 children in detroit was analyzed by mold specific quantitative pcr (msqpcr) and the environmental relative moldiness index (ermism) was calculated for each home. children living in these homes were grouped as non-asthmatic (n=83), moderately asthmatic (n=28) and severely asthmatic (n=32) based on prescription medication usage for their asthma management (none, occasional and daily, respectively). the mean ermi for each group of homes was 6.2 for non-a ... | 2008 | 18280542 |
| genetic diversity of aspergillus species isolated from onychomycosis and aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing. | thirteen aspergillus isolates recovered from nails of 13 patients (fingernails, n=2; toenails, n=11) with onychomycosis were characterized. twelve strains were identified by multilocus sequencing as aspergillus spp. (aspergillus sydowii [n=4], aspergillus welwitschiae [n=3], aspergillus terreus [n=2], aspergillus flavus [n=1], aspergillus tubingensis [n=1], and aspergillus unguis [n=1]). isolates of a. terreus, a. flavus, and a. unguis were also identifiable by matrix-assisted laser desorption/i ... | 2016 | 26658315 |
| highly glucose tolerant β-glucosidase from aspergillus unguis: nii 08123 for enhanced hydrolysis of biomass. | aspergillus unguis nii-08123, a filamentous fungus isolated from soil, was found to produce β-glucosidase (bgl) activity with high glucose tolerance. cultivation of the fungus in different carbon sources resulted in the secretion of different isoforms of the enzyme. a low molecular weight isoform, which retained ~60 % activity in the presence of 1.5 m glucose, was purified to homogeneity and the purified enzyme exhibited a temperature and ph optima of 60 °c and 6, respectively. the k(m) and v(ma ... | 2013 | 23732694 |
| infant origins of childhood asthma associated with specific molds. | the specific cause or causes of asthma development must be identified to prevent this disease. | 2012 | 22789397 |
| four chlorinated depsidones from a seaweed-derived strain of aspergillus unguis and their new biological activities. | four chlorinated depsidones (two reported for the second time (1 and 2) and two known (3 and 4)) were isolated from a seaweed-derived aspergillus unguis strain. their structures were spectroscopically elucidated. compounds 1, 3 and 4 strongly inhibited methicillin-resistant staphylococcus aureus (mrsa) with minimum inhibitory concentrations (mics) of 2, 2 and 4 μg/ml and killed artemia larva with lc50 of 4.1, 1.7 and 2.8 μg/ml, respectively. besides, in dna-damaging test, they also selectively i ... | 2014 | 24479775 |
| depsidones, aromatase inhibitors and radical scavenging agents from the marine-derived fungus aspergillus unguis cri282-03. | three new depsidones ( 1, 3, and 4), a new diaryl ether ( 5), and a new natural pyrone ( 9) (synthetically known), together with three known depsidones, nidulin ( 6), nornidulin ( 7), and 2-chlorounguinol ( 8), were isolated from the marine-derived fungus aspergillus unguis cri282-03. aspergillusidone c ( 4) showed the most potent aromatase inhibitory activity with the ic (50) value of 0.74 µm, while depsidones 1, 3, 6- 8 inhibited aromatase with ic (50) values of 1.2-11.2 µm. it was found that ... | 2012 | 22307935 |
| expression system for heterologous protein expression in the filamentous fungus aspergillus unguis. | heterologous protein expression in filamentous fungi is advantageous, especially in the context of large scale production of high volume low value recombinant proteins. however, such systems are rare and not available in public domain. a novel filamentous fungus - aspergillus unguis nii 08123 was used as host for developing a protein expression system. an expression cassette was assembled using a. nidulans glyceraldehyde 3 phosphate dehydrogenase promoter (pgapd), tryptophan synthase transcripti ... | 2017 | 28578805 |
| unguisin c, a gaba-containing cyclic peptide from the fungus emericella unguis. | besides the known unguisins a and b, a new cyclic heptapeptide, unguisin c, containing a gaba-derived moiety in the ring, was isolated from the fungus emericella unguis. the structure was determined by 1d and 2d nmr techniques. marfey's method was used to determine the absolute stereochemistry. precursor-directed biosynthesis of the unguisins was performed by supplementation of the culture medium with amino acids (l-ala, l-ser, l-phe and l-leu). a related cyclic heptapeptide, unguisin d, was det ... | 2002 | 12150814 |
| unguisins a and b: new cyclic peptides from the marine-derived fungus emericella unguis | unguisin a (1) and b (2), the first cyclic heptapeptides containing gaba in the ring, were isolated from a marine-derived strain of emericella unguis. the chemical structures of 1 and 2 were elucidated by extensive 2d nmr techniques, and the stereochemistry of the individual amino acids was determined using marfey's method. | 1999 | 10346973 |
| microbial conversion of compactin (ml-236b) to ml-236a. | approximately 1,600 fungal strains were tested for ability to convert compactin (ml-236b) to ml-236a and emericella unguis ifo 8087 was found to be the most active. e. unguis converted ml-236b to ml-236a with a yield of over 90%. | 1986 | 3793626 |