| the isolation of meaban virus, a new flavivirus from the seabird tick ornithodoros (alectorobius) maritimus in france. | seven strains of a new flavivirus, for which the name of meaban virus is proposed, were isolated from the seabird tick ornithodoros (a.) maritimus collected during 1981 and 1982 in nests of herring gulls (larus argentatus) on islands of south brittany, france. the new virus was compared serologically with 65 other flaviviruses including tyuleniy virus and was found to be most closely related to, but different from saumarez reef virus, an agent previously isolated in australia and tasmania. some ... | 1985 | 2982352 |
| viral infections of little blue penguins (eudyptula minor) along the southern coast of australia. | serum antibodies to strains of avian paramyxovirus and flavivirus were detected in little blue penguins sampled at port campbell and phillip island, victoria, australia. no antibody to newcastle disease virus (ndv) was detected in 267 sera collected, although one penguin captured for experimental studies had a hemagglutination-inhibition antibody titer of 2(4) to this virus. experimental studies showed that the avian paramyxovirus designated apmv-im and strain v4 of ndv were non-pathogenic for p ... | 1985 | 2993680 |
| novel variant of tickborne encephalitis virus, russia. | we isolated a novel strain of tickborne encephalitis virus (tbev), glubinnoe/2004, from a patient with a fatal case in russia. we sequenced the strain, whose landmark features included 57 amino acid substitutions and 5 modified cleavage sites. phylogenetically, glubinnoe/2004 is a novel variant that belongs to the eastern type of tbev. | 2007 | 18258012 |
| ticks associated with macquarie island penguins carry arboviruses from four genera. | macquarie island, a small subantarctic island, is home to rockhopper, royal and king penguins, which are often infested with the globally distributed seabird tick, ixodes uriae. a flavivirus, an orbivirus, a phlebovirus, and a nairovirus were isolated from these ticks and partial sequences obtained. the flavivirus was nearly identical to gadgets gully virus, isolated some 30 year previously, illustrating the remarkable genetic stability of this virus. the nearest relative to the orbivirus (for w ... | 2009 | 19194498 |
| revisiting the clinal concept of evolution and dispersal for the tick-borne flaviviruses by using phylogenetic and biogeographic analyses. | tick-borne flaviviruses (tbf) are widely dispersed across africa, europe, asia, oceania, and north america, and some present a significant threat to human health. seminal studies on tick-borne encephalitis viruses (tbev), based on partial envelope gene sequences, predicted a westward clinal pattern of evolution and dispersal across northern eurasia, terminating in the british isles. we tested this hypothesis using all available full-length open reading frame (orf) tbf sequences. phylogenetic ana ... | 2012 | 22674986 |
| experimental transmission of karshi (mammalian tick-borne flavivirus group) virus by ornithodoros ticks >2,900 days after initial virus exposure supports the role of soft ticks as a long-term maintenance mechanism for certain flaviviruses. | members of the mammalian tick-borne flavivirus group, including tick-borne encephalitis virus, are responsible for at least 10,000 clinical cases of tick-borne encephalitis each year. to attempt to explain the long-term maintenance of members of this group, we followed ornithodoros parkeri, o. sonrai, and o. tartakovskyi for >2,900 days after they had been exposed to karshi virus, a member of the mammalian tick-borne flavivirus group. | 2015 | 26285211 |
| surveillance for arboviral zoonoses in new zealand birds. | given the significant burden that emerging infectious diseases place on global economies and public health, the monitoring and mitigation of, and early response to, potential infectious diseases are of the highest priority. the objective of this study was to survey for known and other potential arboviral zoonoses in multiple bird species at four locations in new zealand. | 2013 | 24478919 |
| biological transmission of arboviruses: reexamination of and new insights into components, mechanisms, and unique traits as well as their evolutionary trends. | among animal viruses, arboviruses are unique in that they depend on arthropod vectors for transmission. field research and laboratory investigations related to the three components of this unique mode of transmission, virus, vector, and vertebrate host, have produced an enormous amount of valuable information that may be found in numerous publications. however, despite many reviews on specific viruses, diseases, or interests, a systematic approach to organizing the available information on all f ... | 0 | 16223950 |
| viral metagenomics on animals as a tool for the detection of zoonoses prior to human infection? | many human viral infections have a zoonotic, i.e., wild or domestic animal, origin. several zoonotic viruses are transmitted to humans directly via contact with an animal or indirectly via exposure to the urine or feces of infected animals or the bite of a bloodsucking arthropod. if a virus is able to adapt and replicate in its new human host, human-to-human transmissions may occur, possibly resulting in an epidemic, such as the a/h1n1 flu pandemic in 2009. thus, predicting emerging zoonotic inf ... | 2014 | 24918293 |
| a glance at subgenomic flavivirus rnas and micrornas in flavivirus infections. | the family flaviviridae comprises a wide variety of viruses that are distributed worldwide, some of which are associated with high rates of morbidity and mortality. there are neither vaccines nor antivirals for most flavivirus infections, reinforcing the importance of research on different aspects of the viral life cycle. during infection, cytoplasmic accumulation of rna fragments mainly originating from the 3' utrs, which have been designated subgenomic flavivirus rnas (sfrnas), has been detect ... | 2016 | 27233361 |
| flaviviruses in europe: complex circulation patterns and their consequences for the diagnosis and control of west nile disease. | in europe, many flaviviruses are endemic (west nile, usutu, tick-borne encephalitis viruses) or occasionally imported (dengue, yellow fever viruses). due to the temporal and geographical co-circulation of flaviviruses in europe, flavivirus differentiation by diagnostic tests is crucial in the adaptation of surveillance and control efforts. serological diagnosis of flavivirus infections is complicated by the antigenic similarities among the flavivirus genus. indeed, most flavivirus antibodies are ... | 2013 | 24225644 |
| [genetic characterization of viruses from the antigenic complex tyuleniy (flaviviridae, flavivirus): tyuleniy virus (tyuv) (id genbank kf815939) isolated from ectoparasites of colonial seabirds--ixodes (ceratixodes) uriae white, 1852, ticks collected in the high latitudes of northern eurasia--and kama virus (kamv) isolated from the ixodes lividus roch, 1844, collected in the digging colonies of the middle part of russian plane]. | genetic research into the tyuleniy virus (tyuv) (id genbank kf815939) isolated in high latitudes from the ixodes uriae white, 1852, ticks collected in the nesting colonies of the alcidae (leach, 1820) birds and kama virus (kamv) (id genbank kf815940) isolated from the i. lividus ticks collected in the nesting bird colonies in the middle part of the russian plane was carried out. full-genome comparative analysis revealed 70% homology between kamv and tyuv on the nucleotide level and 74% on the am ... | 2016 | 25065141 |
| flavidb: a data mining system for knowledge discovery in flaviviruses with direct applications in immunology and vaccinology. | the flavivirus genus is unusually large, comprising more than 70 species, of which more than half are known human pathogens. it includes a set of clinically relevant infectious agents such as dengue, west nile, yellow fever, and japanese encephalitis viruses. although these pathogens have been studied extensively, safe and efficient vaccines lack for the majority of the flaviviruses. | 0 | 25544857 |
| characterization of a novel insect-specific flavivirus from brazil: potential for inhibition of infection of arthropod cells with medically important flaviviruses. | in the past decade, there has been an upsurge in the number of newly described insect-specific flaviviruses isolated pan-globally. we recently described the isolation of a novel flavivirus (tentatively designated 'nhumirim virus'; nhuv) that represents an example of a unique subset of apparently insect-specific viruses that phylogenetically affiliate with dual-host mosquito-borne flaviviruses despite appearing to be limited to replication in mosquito cells. we characterized the in vitro growth p ... | 2014 | 25146007 |
| ecuador paraiso escondido virus, a new flavivirus isolated from new world sand flies in ecuador, is the first representative of a novel clade in the genus flavivirus. | a new flavivirus, ecuador paraiso escondido virus (epev), named after the village where it was discovered, was isolated from sand flies (psathyromyia abonnenci, formerly lutzomyia abonnenci) that are unique to the new world. this represents the first sand fly-borne flavivirus identified in the new world. epev exhibited a typical flavivirus genome organization. nevertheless, the maximum pairwise amino acid sequence identity with currently recognized flaviviruses was 52.8%. phylogenetic analysis o ... | 2015 | 26355096 |
| Tembusu virus in ducks, china. | In China in 2010, a disease outbreak in egg-laying ducks was associated with a flavivirus. The virus was isolated and partially sequenced. The isolate exhibited 87%-91% identity with strains of Tembusu virus, a mosquito-borne flavivirus of the Ntaya virus group. These findings demonstrate emergence of Tembusu virus in ducks. | 2011 | 22000358 |
| structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase. | the flavivirus methyltransferase (mtase) sequentially methylates the n7 and 2'-o positions of the viral rna cap (gpppa-rna → m(7)gpppa-rna → m(7)gpppam-rna), using s-adenosyl-l-methionine (adomet) as a methyl donor. we report here that sinefungin (sin), an adomet analog, inhibits several flaviviruses through suppression of viral mtase. the crystal structure of west nile virus mtase in complex with sin inhibitor at 2.0-å resolution revealed a flavivirus-conserved hydrophobic pocket located next t ... | 2010 | 20685660 |
| structure and functionality in flavivirus ns-proteins: perspectives for drug design. | flaviviridae are small enveloped viruses hosting a positive-sense single-stranded rna genome. besides yellow fever virus, a landmark case in the history of virology, members of the flavivirus genus, such as west nile virus and dengue virus, are increasingly gaining attention due to their re-emergence and incidence in different areas of the world. additional environmental and demographic considerations suggest that novel or known flaviviruses will continue to emerge in the future. nevertheless, u ... | 2010 | 19945487 |
| structural bases for substrate recognition and activity in meaban virus nucleoside-2'-o-methyltransferase. | viral methyltransferases are involved in the mrna capping process, resulting in the transfer of a methyl group from s-adenosyl-l-methionine to capped rna. two groups of methyltransferases (mtases) are known: (guanine-n7)-methyltransferases (n7mtases), adding a methyl group onto the n7 atom of guanine, and (nucleoside-2'-o-)-methyltransferases (2'omtases), adding a methyl group to a ribose hydroxyl. we have expressed and purified two constructs of meaban virus (mv; genus flavivirus) ns5 protein m ... | 2007 | 17473012 |
| the isolation of saumarez reef virus, a new flavivirus, from bird ticks ornithodoros capensis and ixodes eudyptidis in australia. | strains of a new flavivirus, for which the name saumarez reef virus is proposed, were isolated from seabird ticks collected from four localities. two strains were isolated from ticks of the species ornithodoros capensis neumann 1901 collected from the nests of sooty terns, sterna fuscata linnaeus 1766 on coral cays off the east coast of queensland, australia. the other three strains were isolated from ticks of the species ixodes eudyptidis maskell 1885 taken from two dead silver gulls larus nova ... | 1977 | 75000 |
| kama virus (kamv) is an atypical representative of the seabird tick-borne flaviviruses. | according to modern classification, tick-borne flaviviruses have been divided into a mammalian tick-borne virus group and a seabird tick-borne virus group (stbvg). the stbvg includes the tyuleniy virus, meaban virus, saumarez reef virus, and the recently discovered kama virus (kamv). the latter was isolated from ixodes lividus, an obligate parasitic tick of the sand martin (riparia riparia), in 1989 in the central part of the russian plain. in 2014, based on molecular genetic analysis, it was sh ... | 2021 | 34086153 |
| human tick-borne diseases in australia. | there are 17 human-biting ticks known in australia. the bites of ixodes holocyclus, ornithodoros capensis, and ornithodoros gurneyi can cause paralysis, inflammation, and severe local and systemic reactions in humans, respectively. six ticks, including amblyomma triguttatum, bothriocroton hydrosauri, haemaphysalis novaeguineae, ixodes cornuatus, ixodes holocyclus, and ixodes tasmani may transmit coxiella burnetii, rickettsia australis, rickettsia honei, or rickettsia honei subsp. marmionii. thes ... | 2019 | 30746341 |