| nucleolus organizers in mus musculus subspecies and in the rag mouse cell line. | silver staining has been used to detect active nucleolus organizer regions (nor's). by this criterion six mouse chromosomes, numbers 12, 15, 16, 17, 18 and 19, can have an nor. the number and distribution of chromosomes with nor's vary among inbred strains of mus musculus musculus (c57bl/6j, balb/cj, c3h/hej and c3h/stcpr1br) and in m. musculus molossinus. in a musculus x molassinus f1 hybrid, nucleolus organizers from each parent are silver stained.--chromosomes which have nor's in diploid cell ... | 1977 | 69563 |
| molecular characterization of a mouse y chromosomal repetitive sequence that detects transcripts in the testis. | 145sc5 is a y chromosomal repetitive sequence isolated from a balb/c mouse and is unique in that it detects poly(a)-containing transcripts in the testis. we determined nucleotide sequences of 145sc5 and a related cdna clone designated pc11 and compared their sequences to that of pymt2/b, another related cdna clone. 145sc5 and pc11 are almost identical (97%), while pc11 and pymt2/b share 84% identity. in situ hybridization and southern blot analysis with xxsxr male mice demonstrated that 145sc5-r ... | 1992 | 1395731 |
| the mus musculus domesticus tdy allele acts later than the mus musculus musculus tdy allele: a basis for xy sex-reversal in c57bl/6-ypos mice. | consomic c57bl/6 males, carrying either the mus musculus musculus-derived c57bl/6 y chromosome or the mus musculus domesticus-derived poschiavinus y chromosome, were outcrossed to females of the inbred strains c3h/bi and cxbh/by and to females of the random bred strain mf1/ola. in a study at 12.5 days post coitum, gonads of xyc57 and xypos fetuses were assessed for the presence of testicular cords. it was found that xypos fetuses had a later onset of testicular development than xyc57 fetuses. li ... | 1991 | 1782876 |
| incidence of double-band hsrs in chromosome 1 of the house mouse, mus musculus musculus, from oland (sweden): a population study. | the incidence of homogeneously staining regions (hsrs) in chromosome no. 1 of mus musculus musculus was ascertained by c-band staining on chromosomes of mice collected on the island of oland (sweden). a total of 157 specimens from eight localities representing three regions were analysed. mice with enlarged chromosome no. 1, due to double-band hsrs, were found in all three regions. the overall incidence of hsr-bearing chromosomes was 6.7% in mice collected on oland in 1988. in the two largest sa ... | 1991 | 1917541 |
| polymorphic hsrs in chromosome 1 of the two semispecies mus musculus musculus and m. m. domesticus have a common origin in an ancestral population. | hsrs (homogeneously staining regions) are the cytological correlates of dna amplification. in the house mouse, mus musculus, many populations are polymorphic for the presence or absence of hsrs on chromosome 1. in the semispecies m. m. domesticus the amplified dna is present within one hsr, whereas in m. m. musculus chromosomes 1 with two hsrs are found. hybridization of hsr-specific probes to southern blots of hsr-carrying genomic dnas from different localities and semispecies revealed similar ... | 1991 | 2040202 |
| dominant expression of a distinctive v14+ t-cell antigen receptor alpha chain in mice. | a distinctive variable region 14-positive (v14+) alpha chain (v alpha 14+) of the t-cell antigen receptor is predominantly expressed in multiple mouse subspecies. the v alpha 14 family has two members, v alpha 14.1 and v alpha 14.2, which differ by only three amino acids at positions 50-52. based on the ecori restriction fragment length polymorphism of the gene encoding v alpha 14, mice can be divided into three groups: type i with an 11.2-kilobase (kb) fragment, type ii with a 2.0-kb fragment, ... | 1991 | 1881891 |
| pcr-analyzed microsatellites: data concerning laboratory and wild-derived mouse inbred strains. | we have investigated 67 primers designed by dr. j. todd and co-workers to amplify microsatellites sequences in the mouse. we report on additional polymorphisms concerning seven laboratory inbred strains, complementary to those already published. we include the survey of three independently derived strains of mus spretus: spe/pas, seg/pas and spr/smh. spe/pas and seg/pas are very close (3% polymorphism), whereas the third one, (spr/smh), is very different from the other two strains (33% polymorph ... | 1991 | 1794054 |
| [genetic divergence of mus musculus musculus and m. m. hortulanus]. | genetic divergence between house mouse and gleaner mouse from different regions of ukraine was estimated by electrophoresis at 26 loci. four diagnostic loci were established among these species: idh-1, est-1,2,4. genetic distance between species is 0.217, which is in accordance with genetic differences between other species of the genus mus. the results obtained give evidence that house and gleaner mouse are different species. | 1988 | 3250907 |
| the origin of a double insertion of homogeneously staining regions in the house mouse (mus musculus musculus). | a high resolution analysis of the g-band patterns of normal and aberrant chromosomes 1, bearing two linked insertions of homogeneously staining regions (hsrs) in the house mouse (mus musculus musculus) reveals the inverted pattern of the euchromatic region between the hsrs. on the basis of this analysis a hypothesis on the origin of the aberrant chromosome is put forward: the double insertion is a result of an inversion of the chromosome 1 of mus musculus domesticus bearing a single insertion of ... | 1990 | 1703140 |
| [the causes of appearance of a double insertion of homogeneously staining regions in the chromosome 1 of house mouse (mus musculus musculus)]. | a high resolution analysis of g-band pattern of normal and aberrant chromosome 1 bearing two linked insertions of homogeneously staining regions (hsrs) in the house mouse (mus musculus musculus) reveals an inverted pattern of the euchromatic region between the hsrs. on the basis of this analysis, a hypothesis on the causes for appearance of the aberrant chromosome was put forward: the double insertion is a result of inversion of the chromosome 1 of mus musculus domesticus bearing a single long i ... | 1990 | 1693902 |
| immunological comparison between albumins of three species of mice (genus mus). | three closely related species of short-tailed mice (mus musculus musculus, m. spretoides and m. spicilegus) were tentatively discriminated using immunological techniques based on albumin cross-reactivity. different fractionations of crude albumin antisera allowed the recovery of antibody populations specific to the m. m. musculus albumin, whereas antibody population differences do not seem to exist between m. spicilegus and m. spretoides. moreover, immunoreactivities tested with native and s-car ... | 1990 | 1690145 |
| polymorphisms revealed by pcr with single, short-sized, arbitrary primers are reliable markers for mouse and rat gene mapping. | ten single, arbitrarily designed oligodeoxynucleotide primers, with 50-70% (g+c) content, were used to amplify by polymerase chain reaction (pcr) sequences with dna templates from several mouse species (mus spretus, mus musculus musculus, and mus musculus domesticus), as well as dna from the laboratory rat (rattus norvegicus). eight of these ten primers, used either individually or associated in pairs, generated a total of 13 polymorphic products which were used as genetic markers. all of these ... | 1992 | 1617216 |
| inverted repeat structure of the sry locus in mice. | the testis-determining gene sry is located on the short arm of the mouse y chromosome in a region known to have undergone duplications and rearrangements in comparison with the equivalent portion of the human y chromosome. detailed analysis of the sry genomic locus reveals a further difference in that the mouse sry open reading frame lies within 2.8 kilobases of unique sequence at the center of a large inverted repeat. this repeat, which is found in both mus musculus musculus and mus musculus do ... | 1992 | 1518820 |
| wild mice express an ig v lambda gene that differs from any v lambda in balb/c but resembles a human v lambda subgroup. | the lambda l chain locus in the inbred mouse strains commonly used in the laboratory contains a limited number of germ-line genes; only three v lambda and three functional j lambda-c lambda genes have been identified in balb/c mice. previous studies indicated that wild mice may have a considerably expanded number of c lambda genes, as judged by the number of dna restriction fragments that hybridize to c lambda probes derived from balb/c. in order to evaluate the expression of these putative lamb ... | 1992 | 1378065 |
| nucleotide sequence of mouse sry gene is different between y chromosome originating from mus musculus musculus and mus musculus domesticus. | | 1992 | 1349578 |
| expression of an endogenous murine leukemia virus-related proviral sequence is androgen regulated and primarily restricted to the epididymis/vas deferens and oviduct/uterus. | a cdna representing a 5.2-kb defective, endogenous murine leukemia proviral sequence (epi-eps) was isolated from a c57bl/6 mouse cdna epididymal library. northern blot analysis demonstrated that epi-eps was predominantly expressed in the c57bl/6 mouse epididymis and vas deferens with 10-fold lower expression in the seminal vesicle, kidney, and submandibular gland. analysis of tissues from other inbred strains of mice as well as the wild mouse, mus musculus musculus, showed a similar pattern of t ... | 1992 | 1327210 |
| [an experimental study of the mechanisms of precopulatory isolation between 3 genetic forms of the house mouse in the genus mus]. | under experimental conditions, possible mechanisms of precopulatory isolation were studied in house mice of there forms: mus musculus musculus, sympatric m. spicilegus, and allopatric hybrid population of m. m. domesticus x m. m. musculus. in these experiments, the animals were placed in pairs (a male and a female in state of estrus) on a neutral territory. nine combinations of matching were used. no pronounced mechanisms were found to prevent the copulation of partners of different forms. the f ... | 1992 | 1292808 |
| 6-phosphogluconate dehydrogenase (pgd) genetics in the mouse: linkage with metabolically related enzyme loci. | an electrophoretic polymorphism of 6-phosphogluconate dehydrogenase (pgd) has been observed in the subspecies mus musculus musculus from northern denmark. m. m. musculus is interfertile with inbred strains of mice, and f1 hybrids with c57bl/6j show a three-banded phenotype. this pattern is consistent with a dimeric enzyme structure with codominant expression of alleles. in backcrosses and the f2 generation, pgd segregated as a singly autosomal gene, designated pgd, closely linked to gpd-1 on chr ... | 1975 | 1200981 |
| age-related changes in the long bones of the house mouse (mus musculus musculus). | | 1978 | 700542 |
| evidence that wild mice (mus musculus musculus) express lambda genes that differ from those in balb/c. | | 1986 | 3089696 |
| diverse wild mouse origins of xenotropic, mink cell focus-forming, and two types of ecotropic proviral genes. | we analyzed wild mouse dnas for the number and type of proviral genes related to the env sequences of various murine leukemia viruses (mulvs). only mus species closely related to laboratory mice carried these retroviral sequences, and the different subclasses of viral env genes tended to be restricted to specific taxonomic groups. only mus musculus molossinus carried proviral genes which cross-reacted with the inbred mouse ecotropic mulv env gene. the ecotropic viral env sequence associated with ... | 1987 | 3041030 |
| lipoprotein-associated oncornavirus-inactivating factor in the genus mus: effects on murine leukemia viruses of laboratory and exotic mice. | high titers of oncornavirus-inactivating factor (oif) were found previously in sera of laboratory mice. oif is highly active against mouse xenotropic and polytropic envelope recombinant murine leukemia viruses (mulvs) but not against ecotropic mulvs. of the 20 different mouse species or subspecies currently tested, that represent 4 subgenera, no oif was found in the 3 subgenera more distant to the laboratory mouse. in the subgenus mus, 7 of the 8 most distant species had no oif, whereas all the ... | 1987 | 3026614 |
| most classical mus musculus domesticus laboratory mouse strains carry a mus musculus musculus y chromosome. | restriction fragment length polymorphisms (rflps) of maternally inherited mitochondrial dna have revealed that genetic exchanges can occur between populations, subspecies or even species. from the point of view of population genetics the mammalian y chromosome represents a genomic analogue of the mitochondrion; it is inherited only paternally and remains perpetually monosomic, showing little meiotic recombination with other chromosomes. using a y-specific genomic dna probe obtained from a flow-s ... | 1985 | 2986012 |
| allelic variation linked to adenine phosphoribosyltransferase locus in mouse teratocarcinoma cell line and feral-derived mouse strains. | southern blot analysis reveals two distinct adenine phosphoribosyltransferase (aprt) alleles in the p-19 mouse teratocarcinoma cell line. one allele is identical to that observed in common laboratory mouse strains (mus musculus domesticus). the restriction enzyme site variations between the two alleles occur in sequences located both upstream and downstream of the aprt gene, but not within it. although the p-19 cell line was established from a c3h strain embryo (mus musculus domesticus), a sixth ... | 1989 | 2928841 |
| haplotypes that are mosaic for wild-type and t complex-specific alleles in wild mice. | two outstanding problems pertaining to the population dynamics and evolution of the t complex in mice concern the frequency of t haplotypes in the wild and the degree to which these haplotypes recombine with their wild-type homologs. to address these problems, the frequency and distribution of several t complex-associated restriction fragment variants in wild mice were estimated. sixty-four versions of chromosome 17 from wild-derived mus musculus musculus and mus musculus domesticus were examine ... | 1989 | 2573558 |
| the mouse igh-1a and igh-1b h chain constant regions are derived from two distinct isotypic genes. | genetic and structural analyses of the mouse genes encoding constant region of immunoglobulin subclass (igh-c) have shown that recombination is rare within this cluster which is inherited as a set designated the igh haplotype. recent molecular analyses have demonstrated that either dna exchanges or gene duplications have probably occurred during the evolution of this set of genes. in order to assess the generality of the duplication processes, the presence and expression of two allelic forms of ... | 1989 | 2563358 |
| duplication, deletion, and polymorphism in the sex-determining region of the mouse y chromosome. | the zfy gene in the sex-determining region of the human y chromosome encodes a "zinc-finger" protein that may be the testis-determining factor, tdf. although the y chromosomes of most placental mammals carry a single homolog of zfy, the mouse y chromosome has two homologs, both in the sex-determining (sxr) region. zfy-1 alone may suffice to determine maleness; zfy-2 is dispensable, as it was deleted in an sxr variant that retains sex-determining function but has lost other genes. both loci mappe ... | 1989 | 2563173 |
| [effect of heterozygosity for insertions of homogeneously stained regions in chromosome 1 of the house mouse on synapsis in meiotic prophase]. | electron microscope analysis of surface-spread synaptonemal complexes (sc) in oocytes and spermatocytes from double cis heterozygotes for is(hsr; 1c5)1icg and is(hsr; 1e3)2icg was carried out. aberrant chromosomes were isolated from the feral population of mus musculus musculus of novosibirsk. they contain homogeneously stained regions of total length of about 30% of chr 1 mitotic metaphase. heteromorphic bivalents of chr1 with different lengths of the lateral elements of sc and the loop in the ... | 1989 | 2472304 |
| structure and in vitro transcription of the rat cyp2a1 and cyp2a2 genes and regional localization of the cyp2a gene subfamily on mouse chromosome 7. | the cyp2a1 and cyp2a2 genes code for hepatic steroid hydroxylases and differ in their development regulation and expression in male and female rats. in order to explore the mechanism of regulation of these two genes, both genes were isolated and sequenced, their upstream regions compared, and their promoters transcribed in a cell-free system derived from liver. the cyp2a1 gene was completely sequenced and spanned 12,835 bp. the cyp2a2 gene was sequenced except for 1.5 and 12 kbp in the second an ... | 1990 | 2322568 |
| double insertion of homogeneously staining regions in chromosome 1 of wild mus musculus musculus: effects on chromosome pairing and recombination. | an examination of the meiotic pattern of chromosome 1 isolated from a feral mouse population and containing a double insertion (is) of homogeneously staining regions (hsrs) was carried out. the region delineated by the proximal breakpoint of is(hsr;1c5) 1icg and the distal breakpoint of is(hsr;1e3)2icg is desynapsed during the early pachytene stage and heterosynapsed at the midpachytene, as shown by electron microscopic analysis of synaptonemal complexes. the hsrs have no effect on the segregati ... | 1990 | 2159965 |
| molecular analysis of aprt deficiency in mouse p19 teratocarcinoma stem cell line. | we have used four gene probes specific for mouse chromosome 8, including adenine phosphoribosyltransferase (aprt), to demonstrate that the p19 teratocarcinoma stem cell line contains two distinct chromosome 8 homologs. one represents the common laboratory mouse c3h (mus musculus domesticus) homolog while the second homolog was presumably contributed by a feral mus musculus musculus animal. six cell lines with aprt heterozygous deficiencies were isolated from p19 subclones. a molecular analysis o ... | 1991 | 2011791 |
| [genetic analysis of the hybridization zone between two subspecies mus musculus domesticus and mus musculus musculus in bulgaria]. | the hybrid zone between the two subspecies of mice mus musculus domesticus and mus musculus musculus, which has been studied extensively in denmark, crosses europe to the black sea through the alps and the balkans. two hundred and seventy-nine animals were captured in 22 localities along a transect across the balkans. the animals were characterized for seven diagnostic nuclear loci by protein electrophoresis and by restriction pattern analysis of their mitochondrial dna. the nuclear data show a ... | 1988 | 3169546 |
| allelic profile at 37 biochemical loci of two inbred strains of the house mouse derived from wild mus musculus musculus. | two newly established inbred strains derived from mus musculus musculus, designated pwd/ph (f29) and pwk/ph (f33), were examined for their alleles at 37 biochemical loci located on 12 different chromosomes. the allelic pattern showed characteristic differences from those observed in common inbred strains. the genetic distance d between pwk/ph and pwd/ph was 0.027, whereas the corresponding values for the genetic distances between pwk/ph and c57bl/6j, dba/2j, balb/cj and swr/j were 0.777, 0.721, ... | 1988 | 3352221 |
| a unique alpha chain in hemoglobin of "skive" danish mus musculus. | the primary structures of the alpha chains in hemoglobins from three stocks of mice with the hbaw2, hbaw3, and hbaw4 haplotypes were determined to establish whether the tentative alpha-chain assignments based on the results of isoelectric focusing patterns were correct. these hba haplotypes were identified in laboratory descendants of feral mice captured in different parts of the world. hemoglobin from "centreville", maryland, mus musculus domesticus (hbaw2) contains equal amounts of alpha chain ... | 1988 | 3377753 |
| the mus musculus musculus type y chromosome predominates in asian house mice. | | 1987 | 3443290 |
| susceptibility of mus musculus musculus (czech i) mice to salmonella typhimurium infection. | | 1986 | 3525013 |
| absence of y-chromosome introgression across the hybrid zone between mus musculus domesticus and mus musculus musculus. | | 1986 | 3569903 |
| altered turnover of hypoxanthine phosphoribosyltransferase in erythroid cells of mice expressing hprt a and hprt b alleles. | we have previously shown that mice expressing hprt a allele(s) have erythrocyte hypoxanthine phosphoribosyltransferase (hprt) levels that are approximately 25-fold (mus musculus castaneus) and 70-fold (mus spretus) higher than in mice that express the hprt b allele (mus musculus domesticus; c57bi/6j; c3h/heha), and that these differences in erythrocyte hprt levels are due to differences in the turnover rates of the hprt a and b proteins as reticulocytes mature to erythrocytes. we show here that: ... | 1987 | 3609725 |
| isolation and characterization of a mouse y chromosomal repetitive sequence. | the y chromosome plays a dominant role in mammalian sex determination, and characterization of this chromosome is essential to understand the mechanism responsible for testicular differentiation. male mouse genomic dna fragments, cloned into pbr322, were screened for the presence of bkm (a female snake satellite dna)-related sequences, and we obtained a clone (ac11) having a dna fragment from the mouse y chromosome. in addition to a bkm-related sequence, this fragment contained a y chromosomal r ... | 1986 | 3721197 |
| frequency of polymorphisms for alleles encoding for liver proteins of domesticated mice. | three different inbred strains of mice have been crossed with a lethal albino line (cch/c3h) and the liver polypeptides of the parents and offspring examined by two-dimensional polyacrylamide gel electrophoresis for evidences of protein polymorphisms, different alleles of which have gone to fixation in different strains. in the battery of polypeptides considered most favorable for scoring, 3.3 +/- 1.6 percent of the battery exhibited paired variants and 1.6 +/- 1.2 percent, unpaired. an adjustme ... | 1985 | 4056362 |
| [biosystematic study of mice of the genus mus: karyotype and electrophoretic analysis of total proteins]. | two forms of sympatric mice are captured in north - tunisia: long - tailed mouse and short - tailed mouse. they are often considered as two semi - species of genus mus, respectively mus musculus musculus et mus musculus spretus. they have the same karyotype (2n = acrocentrics). the electrophoretic study of total proteins, shows up genetics differences. these two forms of mice may be considered as two different species, as like as mices of europe: mus musculus at long-tailed and mus spretus at sh ... | 1985 | 4091621 |
| amplification of immunoglobulin lambda constant genes in populations of wild mice. | the lambda immunoglobulin light chain (ig lambda) locus of balb/c inbred mice consists of two variable region gene segments (v lambda)1-3, and four constant region gene segments (c lambda)1,2,4,5. each c lambda gene segment is associated with a unique joining segment (j lambda)2,4-7, and they are organized in two paired units, j3c3-j1c1 and j2c2-j4c4 (refs 4, 8). using cdna probes specific for c lambda 1 and c lambda 2 (ref. 9) we have analysed the genomic organization of the c lambda gene segme ... | 1982 | 6817142 |
| identification of the murine mx2 gene: interferon-induced expression of the mx2 protein from the feral mouse gene confers resistance to vesicular stomatitis virus. | the mouse genome contains two related interferon-regulated genes, mx1 and mx2. whereas mx1 codes for the nuclear 72-kda protein that interferes with influenza virus replication after interferon treatment, the mx2 gene is nonfunctional in all laboratory mouse strains examined, since its open reading frame (orf) is interrupted by an insertional mutation and a subsequent frameshift mutation. in the present study, we demonstrate that mx2 mrna of cells from feral mouse strains njl (mus musculus muscu ... | 1999 | 10233954 |
| biochemical markers of three strains derived from japanese wild mouse (mus musculus molossinus). | twenty-eight biochemical markers were examined in three strains (mol-a, mol-n and mol-t) derived from the the japanese wild mouse, mus musculus molossinus, as well as five laboratory strains, mus musculus musculus. the mol strains showed specific alleles at as many as 12 loci. these findings emphasize that the mol strains have significance in future genetic and developmental studies. | 1982 | 6954949 |
| molecular evolution of a y-chromosomal repetitive sequence family in the genus mus. | a 522-base-long y-chromosomal sequence was isolated from a balb/c genomic library and was designated "bf046." it is repeated about 200 times in the male genome, and a difference was detected between the mus musculus musculus and the m. m. domesticus type y chromosomes. bf046-related sequences were present over the entire length of the y chromosome as visualized by in situ hybridization. southern blot analysis against dnas isolated from eight species in the genus mus showed that bf046-related seq ... | 1994 | 7545911 |
| genomic cloning of mouse mif (macrophage inhibitory factor) and genetic mapping of the human and mouse expressed gene and nine mouse pseudogenes. | the single functional mouse gene for mif (macrophage migration inhibitory factor) has been cloned from a p1 library, and its exon/intron structure determined and shown to resemble that of the human gene. the gene was mapped to chromosome 10 using two multilocus crosses between laboratory strains and either mus musculus musculus or mus spretus. nine additional loci containing related sequences, apparently all processed pseudogenes, were also mapped to chromosomes 1, 2, 3, 7, 8, 9, 12, 17, and 19. ... | 1995 | 7558020 |
| spontaneous and ionizing radiation induced mutations involve large events when selecting for loss of an autosomal locus. | the mouse p19h22 embryonal carcinoma cell line contains two distinct chromosome 8 homologs, one derived from mus musculus domesticus (m. domesticus) and the other derived from mus musculus musculus (m. musculus). it also contains a deletion for the m. musculus aprt allele, which is located on chromosome 8. in this study, cells with spontaneous or induced aprt deficiencies were isolated from p19h22 and examined to determine the nature of the mutational events that had occurred. ultraviolet radiat ... | 1995 | 7603506 |
| circular transcripts of the testis-determining gene sry in adult mouse testis. | sry is expressed at higher levels in the adult testis, where no function has been determined, than in the genital ridge, its critical site of action. cdna and 5' race clones isolated from testis or from sry-transfected cell lines have an unusual structure, with 3' sequences located in a 5' position. rnaase protection assays and reverse transcription polymerase chain reactions confirmed that these unusual rna molecules represent the most abundant transcript in testis. furthermore, oligonucleotide ... | 1993 | 7684656 |
| molecular markers near two mouse chromosome 13 genes, muted and pearl, which cause platelet storage pool deficiency (spd). | the recessive muted (mu) and pearl (pe) mutations on chromosome (chr) 13 cause pigment dilution and platelet storage pool deficiency (spd) in mice. in addition, mu causes inner ear abnormalities and pe has symptoms associated with night blindness. using an interspecific backcross involving the wild-derived mus musculus musculus (pwk) stock, we have mapped 33 microsatellite markers and four cdnas relative to mu, pe, and another recessive mutation, satin (sa). analyzing a total of 528 backcross of ... | 1995 | 7719021 |
| mapping of pcr-based markers for mouse chromosome 4 on a backcross penetrant for the misty (m) mutation. | a genetic linkage map for mouse chromosome (chr) 4 (mmu 4) has been constructed with an intersubspecific backcross between the c57bl/ksj strain homozygous for the misty (m) coat color locus and the inbred mus musculus musculus czech ii strain. several recently developed pcr-based simple sequence length polymorphism (sslp) markers have been intercalated among gene-based markers including six anchor loci on mouse chr 4 to assemble this map. marker order and genetic distances are similar to the com ... | 1994 | 7949731 |
| susceptibility of natural hybrids between house mouse subspecies to sarcocystis muris. | a previous study showed that the susceptibility of hybrids between two mus musculus musculus and mus musculus domesticus did not apply to every parasite. the authors proposed that only parasites which exerted enough constraints would induce the selection of poorly compatible systems of resistance in the subspecies. this study completes the previous work. experimental infections of mice of the two subspecies and their hybrids with the tissue-dwelling protozoan sarcocystis muris show that hybrids ... | 2001 | 11165266 |
| molecular map of chromosome 19 including three genes affecting bleeding time: ep, ru, and bm. | the mouse ruby eye (ru) and pale ear (ep) pigment dilution genes cause platelet storage pool deficiency (spd) and prolonged bleeding times. the brachymorphic (bm) gene, in addition to causing skeletal abnormalities, is also associated with prolonged bleeding times. all three hemorrhagic genes are found within 10 cm on chromosome (chr) 19. in this study, 15 microsatellite markers and five cdnas, spanning 21 cm of chr 19, were mapped in relation to the bm, ep, and ru genes in 457 progeny of an int ... | 1994 | 8043950 |
| novel rflps at protooncogene and cancer-related gene loci on mouse chromosomes. | dna probes for the nras, hras, kras2, lck, raf1, met, mycl1, mycn, myb, erbb2, fos, csf1r, and src protooncogene loci; the retinoblastoma gene locus (rb1); the tumor virus integration sites int2, pvt1, and mlv12; and the locus of the tumor-specific antigen t1a were used to screen mouse genomic dnas from rf/j, cast/ei, molf/ei, mus musculus musculus, m. m. poschiavinus, and m. spretus. polymorphic dna fragments for the 18 dna probes have been identified using southern blot hybridization and restr ... | 1993 | 8095010 |
| restriction fragment length polymorphism and evolution of the mouse immunoglobulin constant region gamma loci. | genomic dna from twelve laboratory mouse strains, in addition to 21 wild-derived strains belonging to different taxa (mus musculus domesticus, mus musculus musculus, mus spretus, mus macedonicus, and mus spicilegus) and four mouse strains that are evolutionarily more distant, were analyzed by southern blot for polymorphism of the ig heavy chain constant region gamma isotype (igh-c gamma) and for the distribution of the duplicated igh-1 (c gamma 2 alpha) haplotype. distinct allelic forms of each ... | 1993 | 8099342 |
| polymorphism of the mouse transcription factor-encoding gene e2a. | southern blotting analysis using a cdna probe consisting of the central portion of the e12 coding region has revealed two distinct forms of e2a, one which is common to all inbred and wild mouse strains derived from mus musculus musculus and mus musculus domesticus, whereas the other is less common and has only been found in the wild mouse population of mus musculus domesticus. | 1994 | 8163208 |
| von willebrand disease in the riiis/j mouse is caused by a defect outside of the von willebrand factor gene. | an animal model for human type i von willebrand disease (vwd) has been previously described in the inbred mouse strain riiis/j. murine vwd is characterized by a prolonged bleeding time, normal von willebrand factor (vwf) multimer distribution, autosomal dominant inheritance, and proportionately decreased plasma vwf antigen, ristocetin cofactor, and factor viii (fviii) activities. to study the molecular genetics of murine vwd, a portion of the vwf gene surrounding exon 28 was cloned, sequenced, a ... | 1994 | 8193357 |
| haldane's rule and heterogametic female and male sterility in the mouse. | failed genetic experiments or experiments designed for other purposes sometimes reveal novel genetic information. the interspecific cross between laboratory strain mice of the mus musculus musculus/domesticus complex and the separate species m. spretus is known to produce fertile f1 females and sterile f1 males. infertility of the interspecific f1 xy male is said to be an example of what has become known as haldane's rule: "when in the f1 offspring of two different animal races one sex is absent ... | 1994 | 8200512 |
| dna segments mapped by reciprocal use of microsatellite primers between mouse and rat. | rat microsatellite primers were used for detection of homologous dna segments in the mouse species (mus laboratorius, mus musculus musculus, and mus spretus). twenty five (16.3%) of 153 rat primer pairs amplified specific dna segments, when genomic dna of mice was used as a template in the polymerase chain reaction (pcr). size variation among inbred strains of mice was found for 13 dna segments (8.5%). eight out of the 13 polymorphic dna segments were mapped to a particular chromosome with two s ... | 1993 | 8268655 |
| experimental evidence of genetic determinism in high susceptibility to intestinal pinworm infection in mice: a hybrid zone model. | in the hybrid zone of the two mouse subspecies mus musculus musculus and mus musculus domesticus, mice with hybrid genotypes harbour, on the average, more helminth parasites (cestodes and nematodes) than mice of the two parental taxa. in order to determine the roles played by genetic parameters in this phenomenon, mice with recombined and parental genotypes were experimentally infected with the intestinal pinworm aspiculuris tetraptera, a natural parasite of the house mouse. the results showed t ... | 1993 | 8316436 |
| effect of sperm genotype on chromatid segregation in female mice heterozygous for aberrant chromosome 1. | an aberrant chromosome 1 with two large homogeneously staining insertions was isolated from wild populations of mus musculus musculus. the specific features of the aberrant chromosome have been described elsewhere (agulnik et al. 1990). these include its preferential entry into the oocyte of heterozygous females, increased mortality of homozygotes and decreased fertility of homozygous females. here we present data indicating that chromatid segregation in heterozygous females depends upon which s ... | 1993 | 8319903 |
| region-specific rates of molecular evolution: a fourfold reduction in the rate of accumulation of "silent" mutations in transcribed versus nontranscribed regions of homologous dna fragments derived from two closely related mouse species. | we have sequenced homologous dna fragments of 2.7 and 2.8 kbp derived from the closely related mouse species mus musculus domesticus (m. domesticus) and mus musculus musculus (m. musculus), respectively. these two species diverged approximately 1 million years ago. each dna fragment contains 1.35 kbp of the 3' end of the constitutively expressed 2.2-kbp aprt (adenine phosphoribosyltransferase) gene and a similarly sized nontranscribed region downstream of the aprt gene. the aprt gene region cont ... | 1993 | 8433377 |
| isolation and mapping of novel mouse brain cdna clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains. | abnormal expansion of trinucleotide repeats (trs) has now been implicated in the pathogenesis of at least nine human genetic disorders, particularly those in which anticipation and/or fragile sites have been demonstrated. anticipation, the phenomenon of increasing severity of phenotype in successive generations, has never been seen in species other than man. nevertheless, animal models for the dynamic mutation of trs would be extremely valuable. we have screened a mouse brain cdna library in an ... | 1996 | 8858346 |
| relatedness of mouse satellite deoxyribonucleic acid to deoxyribonucleic acid of various mus species. | mouse (mus musculus musculus) satellite dna is able to reassociate with repeated dna sequences of mus caroli and mus cervicolor, but low thermal stability of the products indicates significant differences between satellite and related dnas of these two mus species. there appear to be several satellite-related populations in m. caroli dna, each of which forms hybrids of low thermal stability with repeated sequences of m. cervicolor dna. dnas from the subspecies mus musculus molossinus and mus mus ... | 1973 | 4519644 |
| neurochemical changes in murine trisomy 16: delay in cholinergic and catecholaminergic systems. | two strains of mus musculus musculus, c57bl/6j and cd-1, and mus musculus poschiavinus, the tobacco mouse, were used to study the effects of increased gene dosage of mouse chromosome 16 (mmu 16). a developmental delay has been found in the brains of murine trisomy 16 (ts16) fetuses. both the brain weight (in all three strains) and dna content (in cd-1) were reduced, while protein content was unchanged in ts16 compared to normal littermates. the daily increments of weight and protein (except in m ... | 1984 | 6145755 |
| mitochondrial dna evolution in mice. | this study extends knowledge of mitochondrial dna (mtdna) diversity in mice to include 208 animals belonging to eight species in the subgenus mus. highly purified mtdna from each has been subjected to high-resolution restriction mapping with respect to the known sequence of one mouse mtdna. variation attributed to base substitutions was encountered at about 200 of the 300 cleavage sites examined, and a length mutation was located in or near the displacement loop. the variability of different fun ... | 1983 | 6315529 |
| metaphase-specific cell death in meiotic spermatocytes in mice. | apoptosis of male germ cells is a widespread but little-understood phenomenon in many animal species. the elucidation of its mechanisms could be useful in the understanding of male infertility. we have examined the distribution of dying cells with the terminal transferase-mediated nick-end labeling (tunel) method and by an electron-microscopic procedure in the testes of 10 mouse strains, viz., c57bl/10 (b10), sl/nia (sl), c57bl/6 (b6), c3h/he (c3h), balb/c (balb), dba2 (dba), cba/j (cba), mrl/mp ... | 1999 | 10382278 |
| genetic analysis of neonatal death with growth retardation in f(1) male dh/+ mice. | nearly all f(1) male mice with dh/+ genotype between ddd female and dh-dh/+ male die within a few days after birth; however, this is not observed in the reciprocal cross. the f(1) dh/+ males usually exhibit growth retardation prior to death. to identify the putative genetic locus or loci in ddd genome that cause the abnormalities in the presence of the dh, a linkage analysis was carried out in backcross progeny of a cross of (ddd female x dh-+/+ male) f(1) female x dh-dh/+ male. appearance of gr ... | 1999 | 10430663 |
| sry requires a cag repeat domain for male sex determination in mus musculus. | sry, the mammalian y-chromosomal sex-determining gene, encodes a protein characterized by a dna-binding and -bending domain referred to as the hmg box. despite the pivotal role of this gene, only the hmg box region has been conserved through evolution, suggesting that sry function depends solely on the hmg box and therefore acts as an architectural transcription factor. in mice (genus mus) sry also includes a large cag trinucleotide repeat region encoding a carboxy-terminal glutamine-rich domain ... | 1999 | 10431249 |
| expression of imprinted genes in cloned mice. | genomic imprinting is a mammalian specific epigenetic modification of the genome. assessment of the integrity of the imprinting memory in somatic cell cloned animals is important not only for understanding of the "reprogramming" process during cloning by nuclear transfer, but also for the applications of this technique for therapeutic cloning in the future. in this chapter, we summarize the analytical methods for assessment of monoallelic expression of imprinting genes and expression analysis. f ... | 2006 | 16988384 |
| reduced nucleotide variability at an androgen-binding protein locus (abpa) in house mice: evidence for positive natural selection. | previous work has shown that the gene for the alpha subunit of androgen-binding protein, abpa, may be involved in premating isolation between different subspecies of the house mouse, mus musculus. we investigated patterns of dna sequence variation at abpa within and between species of mice to test several predictions of a model of neutral molecular evolution. intraspecific variation among 10 mus musculus domesticus alleles was compared with divergence between m. m. domesticus and m. caroli for a ... | 1999 | 10486974 |
| experimental trypanosomiasis of natural hybrids between house mouse subspecies. | this study characterises the extent of the susceptibility to parasites (first demonstrated with helminths) of hybrids between mus musculus domesticus and mus musculus musculus. experimental infections with trypanosoma musculi of m. m. domesticus, m. m. musculus and their natural hybrids have been performed to compare their level of resistance/susceptibility. it appears that contrary to the results with helminths, hybrid mice present the same level of resistance/susceptibility to the trypanosome ... | 1999 | 10501611 |
| pwd/ph and pwk/ph inbred mouse strains of mus m. musculus subspecies--a valuable resource of phenotypic variations and genomic polymorphisms. | pwd/ph and pwk/ph (abbreviated pw*) are highly inbred mouse strains (f66 and f70) derived from wild mice of mus musculus musculus subspecies. when compared with laboratory inbred strains, they display a plethora of differences in many complex phenotypes such as body weight, fat distribution pattern, blood levels of intermediary metabolites, sensitivity to type-1 diabetes or behaviour patterns. the pwd/ph genes can rescue the lethal effect of lack of the igf2 receptor. the male-limited hybrid ste ... | 2000 | 10730880 |
| a single genetic determinant that prevents sex reversal in c57bl-ypos congenic mice. | sex determination in the mammalian embryo begins with the activation of a gene on the y chromosome which triggers a cascade of events that lead to male development. the mechanism by which this gene, designated sry in humans and sry in mice (sex determining region of the y chromosome), is activated remains unknown. likewise, the downstream target genes for sry remain unidentified at present. c57bl mice carrying a y chromosome from mus musculus musculus or molossinus develop normally as males. in ... | 2000 | 11091903 |
| sry promoters from domesticus (tirano) and c57bl/6 mice function similarly in embryos and adult animals. | introduction of the y chromosome from a mus musculus domesticus (tirano) subspecies into the mus musculus musculus c57bl/6 (b6) inbred strain background results in sex reversal in xy offspring. it has been hypothesized that the domesticus testis-determining y (tdy) locus is misregulated in b6 genome, thereby impairing sex determination in b6.y(dom) animals. the identification of a gene in the sex-determining region on the y chromosome (sry) as the tdy has provided a means to experimentally exami ... | 2001 | 11748612 |
| y-chromosomal factor is involved in neonatal lethality in (female symbolddd x male symboldh- dh/+) f(1)- dh/+ male mice. | the dominant hemimelia ( dh) mutation causes various developmental abnormalities in mice. most f(1)- dh/+ males, crosses between ddd females and dh- dh/+ males, have lethal abnormalities during the neonatal period. this is a consequence of synergism among three independent gene loci; that is, the dh allele on chromosome (chr) 1, the ddd allele on an x chr-linked locus, and a y chr-linked locus in some strains. with regard to the y chr derived from mus musculus musculus ( m. m. musculus), the y c ... | 2002 | 11919685 |
| foraging behavioural changes induced by conspecific and heterosubspecific odours in two strains of wild mice. | mice in wild populations of the two subspecies mus musculus domesticus and mus musculus musculus may potentially compete for food. because of the importance of olfaction in mice, we hypothesised that the presence of unfamiliar conspecific or heterosubspecific chemical cues could play a role in access to and use of food resources. we used an experimental design that tested this assumption with males from two strains, originated from wild populations of these subspecies, as subjects. exploratory a ... | 2002 | 12044688 |
| short-term contact elicits heterospecific behavioral discrimination of individual odors in mound-building mice (mus spicilegus). | the authors used a habituation-dishabituation procedure to test the ability of male mound-building mice (mus spicilegus) to discriminate individual odors from males of another species of mouse. male mound-building mice failed to spontaneously discriminate individual odors from mus musculus musculus males, a natural competitor. after 24-hr contact with a male of one of the m. musculus subspecies (m. m. musculus or m. m. domesticus), experienced m. spicilegus males discriminated the individual odo ... | 2002 | 12539931 |
| polymorphisms of mouse apolipoprotein a-ii: seven alleles found among 41 inbred strains of mice. | in mice, apolipoprotein a-ii (apoa-ii) associates to form amyloid fibrils in an age-associated manner. we determined the complete nucleotide sequences of the apoa-ii gene (apoa2) cdna in 41 inbred strains of mice including mus musculus domesticus (laboratory mouse), mus musculus castaneus, mus musculus molossinus, mus musculus musculus and mus spretus. among these strains we identified 7 alleles (apoa2a1, apoa2a2, apoa2b, apoa2c, apoa2d, apoa2e and apoa2f). polymorphisms of nucleotides at 15 pos ... | 2003 | 14986479 |
| strong premating divergence in a unimodal hybrid zone between two subspecies of the house mouse. | although selection against hybridization is expected to generate prezygotic divergence in unimodal hybrid zones, such a pattern has been seldom described. this study aims to better understand how prezygotic mechanisms may evolve in such zones. we investigated prezygotic divergence between populations of two subspecies of mice (mus musculus musculus and m. m. domesticus) located at the edges of their unimodal hybrid zone in denmark, and we developed an original multiple-population choice-test des ... | 2004 | 15000659 |
| exploration and risk assessment: a comparative study of male house mice (mus musculus musculus) and two laboratory strains. | the ability to gather information and assess risks in novel environments is crucial for survival and fitness in the wild. our aim was to characterise behavioural strategies of exploration and risk assessment in novel environments and to investigate in what respects wild house mice differ from domesticated mice. a total of 39 adult male mice from three genetic backgrounds (wild, balb/c, and c57bl/6) were tested in three behavioural tests, the concentric square field (csf), a modified open field ( ... | 2004 | 15178164 |
| genetic analysis of x-linked hybrid sterility in the house mouse. | hybrid sterility is a common postzygotic reproductive isolation mechanism that appears in the early stages of speciation of various organisms. mus musculus musculus and mus musculus domesticus represent two recently separated mouse subspecies particularly suitable for genetic studies of hybrid sterility. here we show that the introgression of chr x of m. m. musculus origin (pwd/ph inbred strain, henceforth pwd) into the genetic background of the c57bl/6j (henceforth b6) inbred strain (predominan ... | 2004 | 15366371 |
| intraspecific mating with czechii/ei mice rescue lethality associated with loss of function mutations of the imprinted genes, igf2r and cdkn1c. | maternal inheritance of targeted loss of function alleles encoding either the cyclin-dependent kinase inhibitor 1c (cdkn1c) or the insulin-like growth factor 2 receptor (igf2r) leads to fully penetrant perinatal lethality in c57bl/6j mice due to genomic imprinting. here, we demonstrate that there is a marked enhancement in postnatal viability of f(1) mice carrying either the ablated igf2r ( approximately 32%) or cdkn1c ( approximately 83%) when the paternal genome was derived from the inbred mus ... | 2004 | 15475262 |
| behavioral characterization of wild derived male mice (mus musculus musculus) of the pwd/ph inbred strain: high exploration compared to c57bl/6j. | pwd/ph is an inbred mouse strain derived from wild mice trapped in central czech republic. these mice are of the mus musculus musculus subspecies, whose ancestors separated from those of mus musculus domesticus about one million years ago. there is a high degree of variation in the genomic sequence and a wide range of phenotypes between pwd/ph and standard laboratory inbred mouse strains, the genomes of which are principally mus musculus domesticus in origin, making pwd/ph mice an useful resourc ... | 2004 | 15520518 |
| characterization of diabetes-related traits in msm and jf1 mice on high-fat diet. | we examined the effect of a high-fat diet on the diabetes-related traits of the japanese fancy mouse 1 (jf1), msm, and c57bl/6j (b6j) mice. msm and jf1 mice were derived from mus musculus molossinus. b6j is a commonly used laboratory strain, with the vast majority of genome segments derived from mus musculus domesticus and mus musculus musculus, and is susceptible to high-fat diet-induced type 2 diabetes. none of the strains showed symptoms of diabetes or obesity when fed a laboratory chow diet. ... | 2004 | 15542353 |
| the hsr chromosome 1 in the house mouse, mus musculus, from regions of the urals polluted by mutagens. | the incidence of the hsr chromosome 1 was examined in mus musculus musculus from 12 localities of the middle and south urals and northwestern siberia. the hsr chromosome was found in 7 localities, its frequency varying from 5 up to 18%. the hsr incidence was shown to correlate with the mean pooled frequency of aneuploidy and polyploidy in bone marrow, but not with the mean proportion of cells carrying structural chromosome aberrations. in mice heterozygous for hsr the rate of aneuploidy and poly ... | 1996 | 9062084 |
| olfactory preferences in two strains of wild mice, mus musculus musculus and mus musculus domesticus, and their hybrids. | we studied olfactory preferences of two strains of mice, mus musculus musculus and mus musculus domesticus (considered here to be subspecies), and their hybrids, to examine the possible role of odours as a behavioural, premating mechanism that could explain the characteristics of their natural hybrid zone. we used a choice test with the bedding material of animals of the opposite sex from the animal tested and from both subspecies. male and female m. m. domesticus showed no preference either for ... | 1998 | 9787027 |
| [species-specific odor in closely related species: period of development in ontogenesis of house (mus musculus musculus) and mound-building (mus spicilegus) mice]. | in two-choice odor tests, it was shown that house and mound-building mice began to discriminate the species-specific odor of young at the age of 17 days. the mice investigated the odor of conspecific urine significantly longer than that of heterospecific urine, when the young donors of urine, were 17 days old or older. thus, the species-specific odor appears in ontogenesis of these species on the 17th day of life. | 1998 | 9891431 |
| exploration and risk assessment in female wild house mice (mus musculus musculus) and two laboratory strains. | in an evolutionary prospective, it is possible that female mice have a differential perception of novel events than male mice and use a different behavioural strategy for risk assessment. however, female mice are less studied than male mice in behavioural tests of emotional reactivity. the aim of the present study was to investigate how wild-derived female house mice differ from domesticated female mice in their risk assessment strategy. a total of 46 adult female mice, 14 balb/c, 16 c57bl/6 and ... | 2005 | 15708778 |
| selenium-binding protein 2, the major hepatic target for acetaminophen, shows sex differences in protein abundance. | liver samples from female and male mice of two subspecies, mus musculus musculus and mus musculus domesticus, were investigated by a combination of 2-de and maldi-ms. the image analysis of the generated 2-de patterns revealed several protein spots with significant differences in intensity/abundance between the sexes. seven protein spots, which were prominent in 2-de patterns of male mice, but which showed very low intensities in females, were identified as selenium-binding protein 2 (sbp2) also ... | 2006 | 16532517 |
| genomic islands of differentiation between house mouse subspecies. | understanding the genes that contribute to reproductive isolation is essential to understanding speciation, but isolating such genes has proven very difficult. in this study i apply a multilocus test statistic to >10,000 snp markers assayed in wild-derived inbred strains of house mice to identify genomic regions of elevated differentiation between two subspecies of house mice, mus musculus musculus and m. m. domesticus. differentiation was high through approximately 90% of the x chromosome. in a ... | 2006 | 16687734 |
| norwegian house mice (mus musculus musculus/domesticus): distributions, routes of colonization and patterns of hybridization. | we investigated the distributions and routes of colonization of two commensal subspecies of house mouse in norway: mus musculus domesticus and m. m. musculus. five nuclear markers (abpa, d11 cenb2, btk, smcy and zfy2) and a morphological feature (tail length) were used to differentiate the two subspecies and assess their distributions, and mitochondrial (mt) d-loop sequences helped to elucidate their colonization history. m. m. domesticus is the more widespread of the two subspecies, occupying t ... | 2010 | 21044192 |
| species-specific expression of major urinary proteins in the house mice (mus musculus musculus and mus musculus domesticus). | the analysis of expression of pheromone-carrying major urinary proteins (mups) from two subspecies of house mice (mus m. musculus, mus m. domesticus) was studied. it has been previously shown that commensal populations of the two subspecies can discriminate on the basis of urinary signals. mups are predominant urinary proteins that protect pheromones from rapid degradation in a hydrophilic environment, and individuals of m. m. musculus tend to rely on these urinary cues in the process of subspec ... | 2007 | 17333372 |
| genetic analysis of autosomal and x-linked markers across a mouse hybrid zone. | in this paper, we present results of the first comprehensive study of the introgression of both autosomal and sex-chromosome markers across the central european portion of the hybrid zone between two house mouse subspecies, mus musculus musculus and m. m. domesticus. more than 1800 individuals sampled from 105 sites were analyzed with a set of allozyme loci (hopefully representing neutral or nearly neutral markers) and x-linked loci (which are assumed to be under selection). the zone center is b ... | 2007 | 17439609 |
| development of unique house mouse resources suitable for evolutionary studies of speciation. | two house mouse subspecies, mus musculus domesticus and mus musculus musculus, form a hybrid zone in europe and represent a suitable model for inferring the genes contributing to isolation barriers between parental taxa. despite long-term intensive studies of this hybrid zone, we still know relatively little about the causes and mechanisms maintaining the 2 taxa as separate subspecies; therefore, to gain insight into this process, we developed 8 wild-derived inbred house mouse strains. in order ... | 2008 | 17965200 |
| variation in mate preference across a house mouse hybrid zone. | reproductive character displacement is known to occur at the borders of a secondary contact zone between the two european subspecies of the house mouse (in jutland, denmark), where selection against hybridization occurs. this study assessed patterns of mate preference in naturally occurring hybrids of the two subspecies. mate odour choice was investigated in male and female mice sampled across the hybrid zone. odour samples comprised urine (from the opposite sex to the test animal) obtained from ... | 2008 | 18414506 |
| there is no heterotic effect upon developmental stability in the ventral side of the skull within the house mouse hybrid zone. | fluctuating asymmetry (fa) of a body is expected to be related to an organism's developmental instability. we studied patterns of fa in the ventral side of the skull along a transect across the central-european portion of the hybrid zone between two house mouse subspecies, mus musculus musculus and mus musculus domesticus. we found that fa was not significantly different between introgression classes relative to differences between localities within those classes and that the within-class differ ... | 2008 | 18462319 |
| telomere attrition due to infection. | telomeres--the terminal caps of chromosomes--become shorter as individuals age, and there is much interest in determining what causes telomere attrition since this process may play a role in biological aging. the leading hypothesis is that telomere attrition is due to inflammation, exposure to infectious agents, and other types of oxidative stress, which damage telomeres and impair their repair mechanisms. several lines of evidence support this hypothesis, including observational findings that p ... | 2008 | 18478110 |
| [genetic differentiation of subspecies of the house mouse mus musculus and their taxonomic relationships inferred from rapd-pcr data]. | genetic differentiation of six subspecies of the house mouse mus musculus (mus musculus musculus. m. m. domesticus, m. m. castaneus, m. m. gansuensis, m. m. wagneri, and m. m. ssp. (bactrianus?) was examined using rapd-pcr analysis. in all, 373 loci of total length of about 530 kb were identified. taxon-specific molecular markers were detected and the levels of genetic differences among the subspecies were estimated. different degree of subspecific genetic differentiation was shown. the most sim ... | 2008 | 18727395 |
| signalling components of the house mouse mate recognition system. | subspecies-specific mate recognition may represent significant barrier to gene flow between diverged genomes potentially leading to speciation. in the house mouse, assortative mating involves the coevolution of several signals and receptors. we compared signalling ability of bedding material, faeces, urine, saliva, salivary androgen binding proteins (abp) and combinations of urine with saliva and urine with abp in mate choice in two wild-derived inbred strains (one of mus musculus musculus and o ... | 2009 | 18790024 |
| the diverse origins of new zealand house mice. | molecular markers and morphological characters can help infer the colonization history of organisms. a combination of mitochondrial (mt) d-loop dna sequences, nuclear dna data, external measurements and skull characteristics shows that house mice (mus musculus) in new zealand and its outlying islands are descended from very diverse sources. the predominant genome is mus musculus domesticus (from western europe), but mus musculus musculus (from central europe) and mus musculus castaneus (from sou ... | 2009 | 18826937 |