| effects of ski 306x, a new herbal agent, on proteoglycan degradation in cartilage explant culture and collagenase-induced rabbit osteoarthritis model. | protective effects of ski 306x, a natural herbal product extracted from three herbs clematis mandshurica, trichosanthes kirilowii, and prunella vulgaris, on articular cartilage was examined and compared with other osteoarthritis (oa) drugs using in vitro and in vivo models. | 2002 | 12056850 |
| inhibition of immediate-type allergic reactions by prunella vulgaris in a murine model. | we studied the effect of aqueous extract of prunella vulgaris (labiatae) (pvae) on immediate-type allergic reactions. pvae (0.005 to 1 g/kg) dose-dependently inhibited systemic anaphylactic shock induced by compound 48/ 80 in rats. when pvae was given as pretreatment, at concentrations ranging from 0.005 to 1 g/kg, the serum histamine levels induced by compound 48/ 80 were reduced in a dose-dependent manner. pvae (0.001 to 1 g/kg) inhibited the passive cutaneous anaphylaxis activated by anti-din ... | 2001 | 11694032 |
| [studies on the medicinal plant in the "sambutsu-cho" of higo province possessed by the kumamoto clan (ii): on the medicina herbs]. | in the previous report, i studied the medicinal trees contained in the sambutsu-cho of the kumamoto clan in higo province. in this report, i studied the medicinal herbs contained in the same book. there were 439 names in the herbal part. i identified 214 species and found 129 species as the medicinal plants. the ratio of the medicinal plants was 60%. the famous medicinal plants were as follows: atractilodes japonica, platycodon grandiflorum, prunella vulgaris var. lilacina, pharbitis nil, cnidiu ... | 1993 | 11639722 |
| a comparison of hiv-1 integrase inhibition by aqueous and methanol extracts of chinese medicinal herbs. | the aqueous and methanol extracts of twenty herbs traditionally used in chinese medicine were screened for anti-hiv-1 integrase activity in a non-radioactive elisa-based hiv-1 integrase assay. the screening was performed at an herb extract concentration of 50 microg/ml. it was found that most of the aqueous and methanol herb extracts could elicit strong inhibition of hiv-i integrase activity. the inhibition was most likely due to tannins or polyphenolics in the herb extracts. in most of the herb ... | 2001 | 11263681 |
| a comparison of human immunodeficiency virus type-1 protease inhibition activities by the aqueous and methanol extracts of chinese medicinal herbs. | the aqueous and methanol extracts of thirty-one herbs traditionally used as anti-fever remedies in china were screened for their in vitro inhibition on human immunodeficiency virus type-1 protease (hiv-1 pr). the activity of recombinant hiv-1 protease was determined by sequence-specific cleavage at the tyr-pro bond of the fluorogenic substrate (arg-glu(edans)-ser-gln-asn-tyr-pro-ile-val-gln-lys(dabcyl)- arg) or by hplc anaylsis of the cleavage products after incubation of the enzyme with a synth ... | 2000 | 11106004 |
| anti-allergic and anti-inflammatory triterpenes from the herb of prunella vulgaris. | the activity-guided fractionation of the extract of the herb of prunella vulgaris (labiatae) led to the isolation of four triterpenes, i.e., betulinic acid, ursolic acid, 2 alpha,3 alpha-dihydroxyurs-12-en-28-oic acid, and 2 alpha-hydroxyursolic acid. one of these compounds, 2 alpha,3 alpha-dihydroxyursolic acid, demonstrated significant inhibition on the release of beta-hexosaminidase from the cultured rbl-2h3 cells in a dose-dependent manner; the ic50 value was calculated to be 57 microm. when ... | 2000 | 10865455 |
| extract of prunella vulgaris spikes inhibits hiv replication at reverse transcription in vitro and can be absorbed from intestine in vivo. | it has been reported that extracts of the spike of prunella vulgaris (ps) exhibit anti-hiv activity at the adsorption and reverse transcription stages. in this study, the actual activity of ps in cells, kinetic analysis of the inhibitory activity of ps against hiv reverse transcriptase and the feasibility of oral administration were examined. first, to clarify whether this extract shows anti-hiv activity in cells in vitro, the number of copies of proviral dna in hiv-exposed cells was calculated. ... | 2000 | 10819439 |
| antioxidative and free radical scavenging activities of selected medicinal herbs. | the antioxidative and superoxide- and hydroxyl radical-scavenging activities and pro-oxidant effect of twelve selected medicinal herbs were studied. the aqueous extracts of coptis chinensis, paeonia suffruticosa, prunella vulgaris and senecio scandens exhibited the highest potency in inhibiting rat erythrocyte hemolysis and lipid peroxidation in rat kidney and brain homogenates. the aforementioned four herbs also demonstrated strong superoxide- and hydroxyl radical-scavenging activity, but exert ... | 2000 | 10680580 |
| isolation and characterization of an anti-hsv polysaccharide from prunella vulgaris. | a water soluble substance was isolated from a chinese herb, prunella vulgaris, by hot water extraction, ethanol precipitation and gel permeation column chromatography. chemical tests showed that the substance was an anionic polysaccharide. using a plaque reduction assay, the polysaccharide at 100 microg/ml was active against the herpes simplex virus types 1 and 2 (hsv-1 and hsv-2), but was inactive against cytomegalovirus, the human influenza virus types a and b, the poliovirus type 1 or the ves ... | 1999 | 10588332 |
| anti-hiv-1 activity of herbs in labiatae. | the anti-hiv-1 activity of aromatic herbs in labiatae was evaluated in vitro. forty five extract from among 51 samples obtained from 46 herb species showed significant inhibitory effects against hiv-1 induced cytopathogenicity in mt-4 cells. in particular, the aqueous extracts of melissa officinalis, a family of mentha x piperita "grapefruit mint," mentha x piperita var. crispa, ocimum basilicum cv "cinnamon," perilla frutescens var. crispa f. viridis, prunella vulgaris subsp. asiatica and satur ... | 1998 | 9743251 |
| [screening test of crude drug extract on anti-hiv activity]. | the anti-hiv-1 effects of 204 crude drugs of common use in japan were evaluated in vitro. as a result, 45 samples inhibited hiv-1-induced cytopathogenicity in mt-4 cells. in particular, the hot water extracts of lithospermum erythrorhizon (root) and prunella vulgaris (spike) showed the strongest anti-hiv-1 activities. their ic100 values were both 16 micrograms/ml. in general, the hot water extracts of the crude drug suppressed the replication of hiv-1 growth more strongly than the cold water ext ... | 1993 | 8277430 |
| antimutagenic activity of extracts from anticancer drugs in chinese medicine. | the antimutagenic activities of extracts of 36 commonly used anticancer crude drugs from chinese herbs were studied by using the salmonella/microsomal system in the presence of picrolonic acid or benzo[a]pyrene to test whether they contain direct or indirect antimutagens. each crude drug was extracted with boiling water for 2 h, the method which is commonly used by chinese people to prepare the drug for oral intake. the extracts of pteris multifida p. showed the highest antimutagenic activity ag ... | 1988 | 3278214 |
| isolation, purification, and partial characterization of prunellin, an anti-hiv component from aqueous extracts of prunella vulgaris. | prunellin, an anti-hiv active compound, was isolated from aqueous extracts of the chinese medicinal herb, prunella vulgaris, and purified to chromatographic homogeneity. infrared and nmr spectroscopy identified prunellin as a polysaccharide. elemental analyses, precipitation with calcium(ii), barium(ii), or 9-aminoacridine suggest a sulfated polysaccharide. paper chromatography of the exhaustively hydrolyzed material indicates the presence of glucose, galactose, xylose, gluconic acid, galactonic ... | 1989 | 2802570 |
| inhibition of lentivirus replication by aqueous extracts of prunella vulgaris. | various members of the mint family have been used historically in chinese and native american medicine. many of these same family members, including prunella vulgaris, have been reported to have anti-viral activities. to further characterize the anti-lentiviral activities of p. vulgaris, water and ethanol extractions were tested for their ability to inhibit equine infectious anemia virus (eiav) replication. | 2009 | 19154592 |
| [experimental study of 472 herbs with antiviral action against the herpes simplex virus]. | using tissue culture method, the present work with its first-hand observation was primarily concerned with evaluating the antiviral effect of 472 traditional medicinal herbs (comprising raw material 10 mg/ml), through both initial (qualitative) and repeated (quantitative) screens, on type 1 herpes simplex virus. when dealing with water and alcoholic extracts, the effective herbs during initial screens were reduced after repeated screens by a range of 28.8-80.0%. employing the basic value attaine ... | 1990 | 2161714 |
| mechanism of inhibition of hiv-1 infection in vitro by purified extract of prunella vulgaris. | crude extracts of four chinese herbs, arctium lappa, astragalus membranaceus, andrographis paniculata, and prunella vulgaris, were assessed in several tissue culture lines for anti-hiv activity and for cytotoxicity. one extract, obtained from p. vulgaris, was able to significantly inhibit hiv-1 replication with relatively low cytotoxicity. the active factor was purified using sequential precipitations with ethanol and n-butanol, followed by reverse-phase and gel permeation high-performance liqui ... | 1992 | 1371029 |
| immune modulatory effects of prunella vulgaris l. on monocytes/macrophages. | prunella vulgaris l. (labiatae), a popular western and chinese herbal medicine, has long been associated with anti-viral and anti-bacterial effects. while its anti-viral effects are attributed mainly to the inhibition of virus replication, the biological mechanisms of its anti-bacterial effects remain unknown. as a biological response modifier (brm), the polysaccharides isolated from p. vulgaris have been shown to up-regulate the immune responses of monocytes/macrophages. however, the immune sti ... | 2005 | 16273294 |
| cytoprotectivity of prunella vulgaris on doxorubicin-treated rat cardiomyocytes. | the cardioprotective effect of prunella vulgaris ethylacetate fraction (pvef) and its constituent rosmarinic acid (ra) was evaluated on isolated rat cardiomyocytes subjected to doxorubicin-induced oxidative stress. the cytoprotectivities of pvef and ra were concentration-dependent in the range of 0.005 to 0.05 mg/ml and the effect of pvef correlated with the ra content. dexrazoxan (de), used as positive control, was less effective than pvef or ra. | 2005 | 15972250 |
| clematis mandshurica protected to apoptosis of rat chondrocytes. | to investigate the effect of ski 306x, a purified extract from the mixture of three herbs, i.e. clematis mandshurica, trichosanthes kirilowii and prunella vulgaris, on apoptosis in chondrocytes. | 2005 | 15967610 |
| [establishment of stably expressed human rantes gene in prunella vulgaris cell clone]. | to express interesting human genes in herbal cells for boosting their specific pharmacological activities, rantes gene cloned from human peripheral blood lymphocyte (pbl) mrna was introduced into a. tumefaciens strain lba4404 harboring pal4404 plasmid via tumor-inducing (ti) plasmid-derived intermediate expression vector prokii. in vitro cultured p. vulgaris cells were transformed by leaf-disk cocultivation procedure. integration of rantes gene in the genome of transformed cells was confirmed by ... | 2003 | 15966316 |
| in vitro and in vivo immunosuppressive activity of spica prunellae ethanol extract on the immune responses in mice. | the immunosuppressive activity of the ethanol extract of spica prunellae (prunella vulgaris fruiting spikes) (eesp) consisting of a mixture of triterpenoids, flavonoids, tannins and polysaccharide was studied on the immune responses in mice. the effects of eesp on mice splenocyte proliferation in vitro were measured. eesp significantly suppressed concanavalin a (con a)- and lipopolysaccharide (lps)-stimulated splenocyte proliferation in vitro in a concentration-dependent manner. furthermore, the ... | 2005 | 15919165 |
| a polysaccharide fraction from medicinal herb prunella vulgaris downregulates the expression of herpes simplex virus antigen in vero cells. | herpes simplex viruses (hsv) are pathogenic. with the emergence of drug-resistant strains of hsv, new antiviral agents, especially those with different modes of action, are urgently needed. prunella vulgaris l. (labiatae), a perennial plant commonly found in china and europe, has long been used as a folk medicine to cure ailments. in this study, a polysaccharide fraction was prepared from prunella vulgaris (ppv), and its effects on the expressions of hsv-1 and hsv-2 antigens in their host vero c ... | 2004 | 15182906 |
| phenolics-rich extracts from silybum marianum and prunella vulgaris reduce a high-sucrose diet induced oxidative stress in hereditary hypertriglyceridemic rats. | the study tested the effects of phenolics-rich extracts from the plants silybum marianum (silymarin) and prunella vulgaris (pve) on blood and liver antioxidant status and lipoprotein metabolism. hereditary hypertriglyceridemic rats fed on standard diet (std) or high-sucrose diet (hsd, 70cal% of sucrose) for two weeks were used. hsd doubled plasma and liver triacylglycerol (tag) and increased plasma vldl-tag and vldl-cholesterol compared to std. administration of silymarin or pve as 1% dietary su ... | 2004 | 15177299 |
| biological activities of prunella vulgaris extract. | the organic fraction (of; 25.7% w/w of rosmarinic acid) of prunella vulgaris (total extract) was found to exhibit the following: scavenging activity on diphenylpicrylhydrazyl radical (dpph), inhibition of in vitro human ldl cu(ii)-mediated oxidation, protection of rat mitochondria and rat hepatocytes exposed to either tert-butyl hydroperoxide, or to cu(ii) and fe(iii) ions. of also showed a potential to inhibit rat erythrocyte haemolysis and it reduced the production of ltb(4) in bovine pmnl gen ... | 2003 | 14595592 |
| inhibitory effects of rosmarinic acid on lck sh2 domain binding to a synthetic phosphopeptide. | in the course of screening inhibitors from the methanol (meoh) extracts of 168 medicinal plants against lymphocyte cell-specific kinase (lck) src -homology 2 (sh2) binding to a synthetic phosphotyrosine-containing peptide (phosphopeptide), we isolated rosmarinic acid from the meoh extract of prunella vulgaris, which showed specific inhibitory activity. the ic 50 value for lck sh2 binding to phosphopeptide (sgsgeepqpyeeipi) of hamster polyomavirus middle-sized tumor (hmt py324) was 7 microm. howe ... | 2003 | 12898421 |
| rosmarinic acid inhibits tcr-induced t cell activation and proliferation in an lck-dependent manner. | lck is a t cell-restricted src family protein tyrosine kinase that plays pivotal roles in tcr-mediated signaling. we aimed to identify novel agents that could disrupt the molecular interaction of the src homology 2-domain of lck (lck sh2) with its binding partners, with the expectation that this would impair tcr signaling and generate immunosuppression. large-scale screening of plant extracts indicated that rosmarinic acid (rosa) in extracts of prunella vulgaris consistently inhibits the interac ... | 2003 | 12672052 |
| identification of inhibitors of the hiv-1 gp41 six-helix bundle formation from extracts of chinese medicinal herbs prunella vulgaris and rhizoma cibotte. | an increasing portion of patients with hiv infection and/or aids cannot use currently fda-approved anti-hiv drugs, including the reverse transcriptase and protease inhibitors, due to the adverse effects and the emergence of drug resistance. thus, it is essential to develop new anti-hiv agents with a target different from the hiv reverse transcriptase and protease. using a conformation-specific monoclonal antibody nc-1, we previously established a high throughput screening assay for identificatio ... | 2002 | 12151056 |
| parental use of the term "hot qi" to describe symptoms in their children in hong kong: a cross sectional survey "hot qi" in children. | the chinese term "hot qi" is often used by parents to describe symptoms in their children. the current study was carried out to estimate the prevalence of using the chinese term "hot qi" to describe symptoms in children by their parents and the symptomatology of "hot qi". | 2006 | 16393344 |
| screening of traditional chinese medicinal plants for quorum-sensing inhibitors activity. | the misuse of antibiotics has contributed to widespread development of antimicrobial resistance among clinically significant bacterial species. alternative approaches other than those using antibiotics are needed in the fight against infectious diseases. quorum sensing (qs) is an intercellular signaling and gene regulatory mechanism, which is used by a number of opportunistic pathogenic bacteria in determining virulence gene expression. the study of qs may yield another strategy for disease cont ... | 2011 | 21439518 |
| photoprotective properties of prunella vulgaris and rosmarinic acid on human keratinocytes. | uva radiation provokes the generation of reactive oxygen species (ros), which induce oxidative stress in the exposed cells leading to extensive cellular damage and cell death either by apoptosis or necrosis. one approach to protecting human skin against the harmful effects of uv radiation is by using herbal compounds as photoprotectants. this study evaluated the protective effects of prunella vulgaris l. (labiatae) and its main phenolic acid component, rosmarinic acid (ra), against uva-induced c ... | 2006 | 16631374 |
| antiviral effect of aqueous extracts from species of the lamiaceae family against herpes simplex virus type 1 and type 2 in vitro. | aqueous extracts from species of the lamiaceae family were examined for their antiviral activity against herpes simplex virus (hsv). extracts from lemon balm (melissa officinalis), peppermint (mentha x piperita), prunella (prunella vulgaris), rosemary (rosmarinus officinalis), sage (salvia officinalis) and thyme (thymus vulgaris) were screened. their inhibitory activity against herpes simplex virus type 1 (hsv-1), type 2 (hsv-2) and an acyclovir-resistant strain of hsv-1 (acv (res)) was tested i ... | 2006 | 17091431 |
| ethnoveterinary medicines used for ruminants in british columbia, canada. | the use of medicinal plants is an option for livestock farmers who are not allowed to use allopathic drugs under certified organic programs or cannot afford to use allopathic drugs for minor health problems of livestock. | 2007 | 17324258 |
| antihyperglycemic activity of prunella vulgaris l. in streptozotocin-induced diabetic mice. | prunella vulgaris l. (labiatae) has been reported to have a wide range of health benefits in oriental medicine. this study for the first time is to examine the antihyperglycemic effects of p. vulgaris in streptozotocin (stz)-induced diabetic icr mice (stz diabetic mice). the effects of p. vulgaris l. aqueous-ethanol extract (pve) on blood glucose, exogenous insulin sensitivity and plasma insulin levels were investigated. in four doses of extracts from the spikes of p. vulgaris, extract at dose o ... | 2007 | 17392144 |
| chemical properties, mode of action, and in vivo anti-herpes activities of a lignin-carbohydrate complex from prunella vulgaris. | the chemical nature, the mode of action, and the in vitro and in vivo anti-hsv activities of the polysaccharide from prunella vulgaris were characterized. the polysaccharide was isolated by ethanol precipitation, dialysis, ctab precipitation, and gel exclusion chromatography. the isolated compound (pps-2b) was a lignin-carbohydrate complex with a molecular weight of 8500. the carbohydrate moiety was composed of glucose, galactose, mannose, galacturonic acid, rhamnose, xylose, and arabinose with ... | 2007 | 17475343 |
| effects of prunella vulgaris on mast cell-mediated allergic reaction and inflammatory cytokine production. | in this study, we investigated the effect of aqueous extract of prunella vulgaris (labiatae; pvae) on the mast cell-mediated allergy model. we found that pvae (0.001-0.1 g/kg) dose dependently inhibited compound 48/80-induced systemic anaphylaxis and serum histamine release in mice. pvae decreased the ige-mediated local allergic reaction, passive cutaneous anaphylaxis. in addition, pvae attenuated phorbol 12-myristate 13-acetate (pma) and calcium ionophore a23187-stimulated tnf-alpha, il-6, and ... | 2007 | 17609508 |
| hplc analysis of rosmarinic acid in feed enriched with aerial parts of prunella vulgaris and its metabolites in pig plasma using dual-channel coulometric detection. | this paper describes a sensitive isocratic hplc/ecd method developed for the determination of rosmarinic acid (ra) in plant material, animal feed, and pig plasma. the plasma sample preparation only includes protein precipitation and adjustment of the ph. the applicability of the method was tested on plasma samples of pigs that were exposed to a 91-day oral intake of ra via feed enriched by aerial parts of prunella vulgaris. the plasma was directly analyzed using the method described as well as a ... | 2007 | 17708641 |
| a cell-based high-throughput protocol to screen entry inhibitors of highly pathogenic viruses with traditional chinese medicines. | emerging viruses such as ebola virus (ebov), lassa virus (lasv), and avian influenza virus h5n1 (aiv) are global health concerns. since there is very limited options (either vaccine or specific therapy) approved for humans against these viruses, there is an urgent need to develop prophylactic and therapeutic treatments. previously we reported a high-throughput screening (hts) protocol to identify entry inhibitors for three highly pathogenic viruses (ebov, lasv, and aiv) using a human immunodefic ... | 2017 | 27704591 |
| characterization of the inhibitory effect of an extract of prunella vulgaris on ebola virus glycoprotein (gp)-mediated virus entry and infection. | currently, no approved antiviral therapeutic is available for treatment or prevention of ebola virus (ebov) infection. in this study, we characterized an ebov-glycoprotein (gp) pseudotyped hiv-1-based vector system in different cell cultures, including human umbilical vein endothelial cells (huvecs) and human macrophages, for the screening of anti-ebov-gp agent(s). based on this system, we demonstrated that an aqueous extract (chpv) from the chinese herb prunella vulgaris displayed a potent inhi ... | 2016 | 26778707 |
| induction of glucokinase mrna by dietary phenolic compounds in rat liver cells in vitro. | diabetes and its complications, including oxidative stress, are major reasons for medical intervention and one of the most frequent causes of death in developed countries. several lines of data suggest that the use of certain dietary polyphenolic compounds may alter glucose metabolism, thus decreasing the risk for type 2 diabetes. in this paper, we present the effect of phenolic acids (caffeic, chlorogenic, rosmarinic, and ferulic) and extracts from smallanthus sonchifolius and prunella vulgaris ... | 2007 | 17715892 |
| heme oxygenase-1 inducing constituent of prunella vulgaris in hepg2 cells. | inducible heme oxygenase (ho)-1 is known to play a major role in the pathogenesis of several diseases, and it protects cells against oxidant-mediated injury. the bioassay-guided fractionation of the etoh extract of the flowered fruit-spike of prunella vulgaris l. (labiatae) yielded two ursane-type triterpenes, 3beta,23-dihydroxyurs-12-en-28-oic acid (23-hydroxyursolic acid) (1) and 3beta-hydroxyurs-12-en-28-oic acid (ursolic acid) (2). western blotting demonstrated that treatment with compound 1 ... | 2008 | 18310925 |
| characterization of antiestrogenic activity of the chinese herb, prunella vulgaris, using in vitro and in vivo (mouse xenograft) models. | prunella vulgaris (pv), a commonly used chinese herb, also known as self-heal, has a wide range of reported medicinal activities. by screening multiple herbs using the endometrial cancer cell line, ecc-1, and an alkaline phosphatase detection assay, we found that pv displayed significant antiestrogenic activity. we investigated the possible usefulness of antiestrogenic activity using both in vitro and in vivo models of endometrial function. using the well-differentiated, hormone-responsive endom ... | 2009 | 18923163 |
| rosmarinic acid in prunella vulgaris ethanol extract inhibits lipopolysaccharide-induced prostaglandin e2 and nitric oxide in raw 264.7 mouse macrophages. | prunella vulgaris has been used therapeutically for inflammation-related conditions for centuries, but systematic studies of its anti-inflammatory activity are lacking and no specific active components have been identified. in this study, water and ethanol extracts of four p. vulgaris accessions were applied to raw 264.7 mouse macrophages, and the ethanol extracts significantly inhibited lipopolysaccharide (lps)-stimulated prostaglandin e2 (pge2) and nitric oxide (no) production at 30 microg/ml ... | 2009 | 19919113 |
| suppression of pma-induced tumor cell invasion and metastasis by aqueous extract isolated from prunella vulgaris via the inhibition of nf-kappab-dependent mmp-9 expression. | matrix metalloproteinase-9 (mmp-9) plays an important role in the invasion and metastasis of cancer cells. in this study, we examined the inhibitory effects of tumor cell migration and invasion by aqueous extract isolated from prunella vulgaris (pvae) using in vitro and in vivo assays. pvae reduced pma-induced activation of mmp-9 and further inhibited cell invasion and migration. pvae suppressed pma-enhanced expression of mmp-9 protein, mrna and transcription activity levels through suppression ... | 2010 | 19922761 |
| altitudinal flower size variation correlates with local pollinator size in a bumblebee-pollinated herb, prunella vulgaris l. (lamiaceae). | the influence of locally different species interactions on trait evolution is a focus of recent evolutionary studies. however, few studies have demonstrated that geographically different pollinator-mediated selection influences geographic variation in floral traits, especially across a narrow geographic range. here, we hypothesized that floral size variation in the japanese herb prunella vulgaris l. (lamiaceae) is affected by geographically different pollinator sizes reflecting different pollina ... | 2015 | 26174480 |
| korean medicine therapy as a substitute for chemotherapy for metastatic breast cancer: a case report. | a 46-year-old korean woman was diagnosed with stage iii breast cancer and underwent 8 cycles of neoadjuvant chemotherapy, breast conservation surgery and adjuvant radiotherapy. however, the cancer recurred in the right upper lung (rul) and the right pulmonary hilum after 8 months. the rul nodule was removed through a wedge resection, and the pathologic finding was revealed as a metastatic adenocarcinoma. adjuvant chemotherapy was recommended, but she refused it because she feared adverse reactio ... | 2017 | 25848354 |
| floral constancy in bumble bees: handling efficiency or perceptual conditioning? | individual bees often prefer flowers of the same species that they are already foraging on, and other individual bees prefer other flowers. this "floral constancy" has classically been explained as a learned behavior by which bees avoid wasting time switching between handling techniques. choice trails were given to bombus vagans workers that were freely foraging in mixed and pure fields of trifolium pratense, t. repens, viccia cracca, and prunella vulgaris. contrary to expectation, (1) bees show ... | 1996 | 28307449 |
| the ameliorating effect of the extract of the flower of prunella vulgaris var. lilacina on drug-induced memory impairments in mice. | prunella vulgaris var. lilacina is widely distributed in korea, japan, china, and europe, and its flowers are used to treat inflammation in traditional chinese medicine. in the present study, we studied the effects of the ethanolic extract of the flower of p. vulgaris var. lilacina (eepv) on drug-induced learning and memory impairment using the passive avoidance, the y-maze, and the morris water maze tasks in mice. eepv (25 or 50 mg/kg, p.o.) significantly ameliorated scopolamine-induced cogniti ... | 2010 | 20362638 |
| [textual research on change of medicinal parts and herbal medicine of prunella vulgaris]. | to investigate the herbal medicine of prunella vulgaris by textual researches, and provide a theoretical basis for clinical medication, exploitation and protection of wild p. vulgaris resources. | 2010 | 20394304 |
| [involvement of jnk and caspase-3 in human lymphoma cell apoptosis induced by prunella vulgaris]. | to characterize the effect of prunella vulgaris upon lymphoma cells and its possible mechanisms. | 2010 | 20450729 |
| prunella vulgaris l. upregulates enos expression in human endothelial cells. | the purported effects of "circulation-improving" herbs used in traditional chinese medicine (tcm) show striking similarities with the vascular actions of nitric oxide (no) produced by the endothelial no synthase (enos). we have previously reported that salviae miltiorrhizae radix and zizyphi spinosae semen upregulate enos expression. in the present study, we studied the effect on enos gene expression of 15 chinese herbs with potential effects on the vasculature, and identified prunella vulgaris ... | 2010 | 20503475 |
| anti-invasion effect of rosmarinic acid via the extracellular signal-regulated kinase and oxidation-reduction pathway in ls174-t cells. | rosmarinic acid is a major phenylpropanoid isolated from prunella vulgaris l., which is a composition of herbal tea for centuries in china. however, the anti-invasion activity on ls174-t human colon carcinoma cells has not been studied. in this study, we investigated the anti-metastasis functions according to wound healing assay, adhesion assay, and transwell assay and found that rosmarinic acid could inhibit migration, adhesion, and invasion dose-dependently. rosmarinic acid also could decrease ... | 2010 | 20506543 |
| traditional chinese medicine syndrome-related herbal prescriptions in treatment of malignant tumors. | to investigate the distribution characteristics of tcm syndromes and the related herbal prescriptions for malignant tumors (mt). | 2013 | 23596807 |
| identification of two polysaccharides from prunella vulgaris l. and evaluation on their anti-lung adenocarcinoma activity. | prunella vulgaris l. (pv) has been used for tumor therapy in traditional chinese medicine for centuries, however, systematic research on extracted pv polysaccharides believed to possess various biological activities, as well as their preventive and anti-tumor effects on lung cancer has not been reported. in this study, two polysaccharides (p31 and p32) were isolated from the aqueous extract of pv and purified through ethanol precipitation, followed by deproteination using deae-52 gel-filtration ... | 2010 | 20714287 |
| effect of polyacetylenic acids from prunella vulgaris on various plant pathogens. | this study is aiming at characterizing antifungal substances from the methanol extract of prunella vulgaris and at investigating those substances' antifungal and antioomycete activities against various plant pathogens. | 2010 | 20849392 |
| antioxidant activities of total phenols of prunella vulgaris l. in vitro and in tumor-bearing mice. | prunella vulgaris l. (pv, labiatae) is known as a self-heal herb. the different extracts of dried spikes were studied for the best antioxidant active compounds. the 60% ethanol extract (p-60) showed strong antioxidant activity based on the results of 2,2'-azino-di(3-ethylbenzthiazoline-6-sulfonic acid (abts˙+), 2,2-diphenyl-1-picrylhydrazyl (dpph) and ferric reducing antioxidant power (frap) assay methods. high performance liquid chromatography (hplc) and lc/ms analysis showed that the main acti ... | 2010 | 21150830 |
| chemoprevention by prunella vulgaris l. extract of non-small cell lung cancer via promoting apoptosis and regulating the cell cycle. | chemoprevention is one feasible approach to decreasing morbidity and mortality of non-small cell lung cancer (nsclc). the present study aimed to explore the mechanisms of chemoprevention of nsclc by prunella vulgaris l. (pv) using a pv extract of 60% ethanol (p-60). in an a/j mouse model benzo[a]pyrene induction of lung tumors was significantly reduced difference by p-60 group. in addition, p-60 was found to have the ability to regulate cell cycle and induce apoptosis in spc-a-1 cells. therefore ... | 2010 | 21198292 |
| apoptogenic activity of 2α,3α-dihydroxyurs-12-ene-28-oic acid from prunella vulgaris var. lilacina is mediated via mitochondria-dependent activation of caspase cascade regulated by bcl-2 in human acute leukemia jurkat t cells. | the dried spikes of prunella vulgaris var. lilacina (labiatae) have been used for traditional herbal medicine to treat fever, inflammation, dropsy, gonorrhea and cancer in korea, japan and china. the present study evaluated the apoptotic effect of 2α,3α-dihydroxyurs-12-en-28-oic acid (dhurs), purified from the dried spikes on human acute leukemia jurkat t cells. | 2011 | 21473903 |
| prunella vulgaris extract and rosmarinic acid suppress lipopolysaccharide-induced alteration in human gingival fibroblasts. | periodontitis is a chronic disease associated with inflammation of the tooth-supporting tissues. the inflammation is initiated by a group of gram-negative anaerobic bacteria. these express a number of irritating factors including a lipopolysaccharide (lps), which plays a key role in periodontal disease development. plant extracts with anti-inflammatory and anti-microbial properties have been shown to inhibit bacterial plaque formation and thus prevent chronic gingivitis. in this study we tested ... | 2009 | 19159670 |
| [study on proteomics of jurkat cells treated with the extracts from prunella vulgaris]. | to analyse the differential proteins of jurkat cells after treated with the extracts from prunella vulgaris using two-dimensional electrophoresis and mass spectrum. | 2009 | 19764330 |
| prunella vulgaris extract and rosmarinic acid prevent uvb-induced dna damage and oxidative stress in hacat keratinocytes. | solar radiation is a very important exogenous factor in skin pathogenesis and can lead to the development of a number of skin disorders. uvb irradiation is known to induce oxidative stress, inflammation and especially dna lesions in exposed cells. it is important, therefore, to identify agents that can offer protection against uvb-caused skin damage. natural compounds have been studied for their possible ability to control/modulate various lifestyle-related diseases. the application of plant com ... | 2010 | 19862537 |
| inhibition of hiv-1 infection by aqueous extracts of prunella vulgaris l. | abstract: | 2011 | 21513560 |
| oleanolic acid from prunella vulgaris l. induces spc-a-1 cell line apoptosis via regulation of bax, bad and bcl-2 expression. | prunella vulgaris l. (pv) has been used as a herb for chemoprevention of lung cancer. in this study, the main active compound, oleanolic acid (oa) was isolated from an ethanol extract and its chemical structure was identified according to the results of high performance liquid chromatography (hplc), high performance thin layer chromatography (hptlc) and liquid chromatography-mass spectrography (lc-ms). results for cell viability indictated no notable differences between oa and ethanol extract of ... | 2011 | 21545203 |
| permeability of rosmarinic acid in prunella vulgaris and ursolic acid in salvia officinalis extracts across caco-2 cell monolayers. | ethnopharmacological relevance: rosmarinic acid (ra), a caffeic acid-related compound found in high concentrations in prunella vulgaris (self-heal), and ursolic acid (ua), a pentacyclic triterpene acid concentrated in salvia officinalis (sage), have been traditionally used to treat inflammation in the mouth, and may also be beneficial for gastrointestinal health in general. aim of the study: to investigate the permeabilities of ra and ua as pure compounds and in prunella vulgaris and salvia offi ... | 2011 | 21798330 |
| evaluation of the anti-neuraminidase activity of the traditional chinese medicines and determination of the anti-influenza a virus effects of the neuraminidase inhibitory tcms in vitro and in vivo. | etnopharmacological relevance: neuraminidase (na) inhibitors are currently the most effective drugs to treat influenza a viruses infection. many traditional chinese medicines (tcms) have been used in the clinics to treat influenza. the anti-viral mechanisms of these tcms and their inhibitory effects towards na need to be systematically tested. | 2011 | 21699971 |
| ethanol extract of prunella vulgaris var. lilacina inhibits hmgb1 release by induction of heme oxygenase-1 in lps-activated raw 264.7 cells and clp-induced septic mice. | the ethanol extract of the flower of p. vulgaris var. lilacina (eepv) has been used traditionally as an antiinflammatory agent in many countries. inducers of heme oxygenase-1 (ho-1) reduce high mobility group box 1 (hmgb1), a late phase cytokine, in sepsis. although eepv has been used as an antiinflammatory agent, no report is available as to whether it modifies hmgb1 in sepsis due to ho-1 induction. it was found that eepv increased ho-1 protein expression in raw 264.7 cells, which was significa ... | 2011 | 21971692 |
| chemopreventive effect of a mixture of chinese herbs (antitumor b) on chemically induced oral carcinogenesis. | in this study, we evaluated chemopreventive efficacy of antitumor b, a chinese herbal mixture of six plants (sophora tonkinensis, polygonum bistorta, prunella vulgaris, sonchus arvensis l., dictamnus dasycarpus, and dioscorea bulbifera) on the development of 4-nitroquinoline-1-oxide (4nqo) induced oral squamous cell carcinomas in a/j mice. antitumor b, delivered through diet, inhibited 4nqo-induced oral cancer development by 59.19%. the reduction of cell proliferation appears to be associated wi ... | 2011 | 22086836 |
| effect of chinese herbal medicine extracts on cell-mediated immunity in a rat model of tuberculosis induced by multiple drug-resistant bacilli. | drug-resistant mycobacterium tuberculosis poses a major threat to public health. the present study aimed to investigate the effects of radix ranunculi ternati, radix sophorae flavescentis, prunella vulgaris l. and stellera chamaejasme l. extracts on cell‑mediated immunity in a rat model of tuberculosis (tb) induced by multiple drug-resistant bacilli. the bacterium was isolated from patients infected with pulmonary tuberculosis. the immunological response in humans following infection with mycoba ... | 2013 | 23716296 |
| biochar mitigates negative effects of salt additions on two herbaceous plant species. | addition of pyrolyzed biomass ("biochar") to soils has commonly been shown to increase crop yields and alleviate plant stresses associated with drought and exposure to toxic materials. here we investigate the ability of biochar (at two dosages: 5 and 50 t ha(-1)) to mitigate salt-induced stress, simulating road salt additions in a factorial glasshouse experiment involving the broadleaved herbaceous plants abutilon theophrasti and prunella vulgaris. salt additions of 30 g m(-2) nacl to unamended ... | 2013 | 23796889 |
| arbuscular mycorrhizal fungi reduce the differences in competitiveness between dominant and subordinate plant species. | in grassland communities, plants can be classified as dominants or subordinates according to their relative abundances, but the factors controlling such distributions remain unclear. here, we test whether the presence of the arbuscular mycorrhizal (am) fungus glomus intraradices affects the competitiveness of two dominant (taraxacum officinale and agrostis capillaris) and two subordinate species (prunella vulgaris and achillea millefolium). plants were grown in pots in the presence or absence of ... | 2013 | 23064770 |
| soil fertilization leads to a decline in between-samples variability of microbial community δ13c profiles in a grassland fertilization experiment. | gas chromatography combustion isotope ratio mass spectrometry (gc-c-irms) was used to measure the (13)c/(12)c ratios of plfas at natural abundance levels from a temperate grassland nitrogen (n) and phosphorus (p) factorial fertilization experiment in northern greece. in each plot two rhizosphere samples were derived centred around individual agrostis capillaris and prunella vulgaris plants. it was hypothesized that the isotopic signal of microbes that preferentially feed on recalcitrant litter s ... | 2012 | 22962602 |
| descriptive study of plant resources in the context of the ethnomedicinal relevance of indigenous flora: a case study from toli peer national park, azad jammu and kashmir, pakistan. | this paper presents the first quantitative ethnobotanical study of the flora in toli peer national park of azad jammu and kashmir, pakistan. being a remote area, there is a strong dependence by local people on ethnobotanical practices. thus, we attempted to record the folk uses of the native plants of the area with a view to acknowledging and documenting the ethnobotanical knowledge. the aims of the study were to compile an inventory of the medicinal plants in the study area and to record the me ... | 2017 | 28192466 |
| [clinical observation of breast hyperplasia treated with auricular point sticking therapy and xiaopijian]. | to observe the efficacy difference in the treatment of breast hyperplasia between the combined therapy of auricular point sticking and xiaopijian and the simple application of xiaopijian. | 2015 | 26571890 |
| fischer's plants in folk beliefs and customs: a previously unknown contribution to the ethnobotany of the polish-lithuanian-belarusian borderland. | historical ethnobotanical studies are useful starting points for further diachronic analysis. the aim of this contribution is to present archival data from the polish-lithuanian-belarusian borderland, which were collected by adam fischer, a polish ethnographer from lviv, in the 1930s. these data were originally gathered for publication in the first part of the lexicon of slavic beliefs and customs, dedicated to plant uses in traditional slavonic culture. it was intended to be a joint internation ... | 2017 | 28335791 |
| [preliminary analysis of bitter substances in spica of prunella vulgaris]. | volatile oil components and the contents and types of amino acid in spica of prunella vulgaris were analysed by gc-ms and amino acid analyzer. esters, fatty acids, aromatic hydrocarbon, ketone and several alcohol compounds were identified by mass spectrum comparison. in these ingredients, beta-ionone smelled aroma of cedar, raspberry, nerolidol showed weak sweet soft orange blossom flavor, neroli tasted sweet and fresh, nerolidol tasted sweet with light aroma of wood, hexadecanal showed a weak a ... | 2014 | 24946541 |
| effects of low levels of herbicides on prairie species of the willamette valley, oregon. | the relative sensitivity of 17 noncrop plant species from oregon's willamette valley was determined in response to glyphosate, tribenuron methyl (tribenuron), and fluazifop-p-butyl (fluazifop) herbicides. for glyphosate, elymus trachycaulus, festuca arundinacea, madia elegans, potentilla gracilis, and ranunculus occidentalis were the most sensitive species, based on a concentration calculated to reduce shoot dry weight by 25% (ic25 values) of 0.02 to 0.04 × a field application rate of 1112 g act ... | 2013 | 23881750 |
| post-dispersal seed fates of four prairie species. | after dispersal, seeds can germinate and establish as seedlings, persist as seeds, or die. knowledge of these three seed fates is crucial for understanding the abundance and distribution of plant populations and ultimately, community composition and diversity. few studies, however, have simultaneously measured these fates, while also examining the factors causing mortality. the goal of this research was to simultaneously quantify the three seed fates and factors causing death (predation and fung ... | 2003 | 21659169 |
| effect of arbuscular mycorrhiza on inter- and intraspecific competition of two grassland species. | we were interested in the role of arbuscular mycorrhiza (am) in the competition between plants of different sizes. a pot experiment of factorial design was established, in which am root colonization and competition were used as treatments. five-week-old prunella vulgaris seedlings were chosen as target plants (i.e. plants whose response to competition was studied) and the following (13 replicates of each) were used as neighbours: (1) a large, 10-week-old p. vulgaris, (2) two p. vulgaris seedling ... | 1996 | 28307736 |
| bacillus wuyishanensis sp. nov., isolated from rhizosphere soil of a medical plant, prunella vulgaris. | a gram-staining-positive, rod-shaped, endospore-forming, aerobic bacterium (fjat-17212(t)) was isolated from the rhizosphere soil of a medical plant, prunella vulgaris (common selfheal), on the wuyishan mountain of china. isolate fjat-17212(t) grew at 10-50 °c (optimum 30 °c), ph 5-11 (optimum ph 7) and with 0-6% (w/v) nacl (optimum 2%). phylogenetic analyses based on 16s rrna gene sequences showed that isolate fjat-17212(t) was a member of the genus bacillus and was most closely related to baci ... | 2015 | 25825245 |
| [anti-hbsag herbs employing elisa technique]. | with the aid of the elisa system this schema represented a laboratory approach to the recognition of anti-hbsag capability of herbs by using 300 herbal extracts. altogether 10 herbs (3.0%) were identified as effective. when forming a multiplex plan by employing 10 average p/n ratios as exemplified by 5 varying doses of herb (0.3, 0.6, 1.2, 2.5, 5.0 mg/100 microliters), 2 varying concentrations of hbsag (10.92, 14.26 p/n ratio), and 3 varying contact time periods (immediate, 1h, 2h) for the compr ... | 1990 | 2268945 |