Publications

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the effect of an ethanol extract of catnip (nepeta cataria) on the behavior of the young chick.the alcohol extract of catnip has a biphasic effect on the behavior of young chicks. low and moderate dose levels (25--1800 mg/kg) cause increasing numbers of chicks to sleep, while high dose levels (i.e. above 2 g/kg) cause a decreasing number of chicks to sleep.1979421844
behavioral and toxicological studies of cyclopentanoid monoterpenes from nepeta cataria.two samples of catnip oil were analyzed by tic, gc, and hplc; the results indicated the presence of 23 components. fractionation of the commercial sample of catnip oil by either distillation or gc yielded 40% nepetalactone and 43% nepetalic acid. catnip oil, nepetalic acid, and a nepetalactone-enriched fraction were evaluated for toxicological and behavioral effects in mice and rats. the ld50 of catnip oil, the nepetalactone-enriched fraction, and nepetalic acid were found in mice to be: 1300 mg ...1978672466
effect of drugs on catnip (nepeta cataria)-induced pleasure behavior in cats. 19725058531
cytochrome p-450-catalysed monoterpenoid oxidation in catmint (nepeta racemosa) and avocado (persea americana); evidence for related enzymes with different activities.a cytochrome p-450 present in ripening avocado (persea americana) fruit mesocarp (cyp71a1) had previously been shown to metabolize the monoterpenoids nerol and geraniol (hallahan et al. (1992) plant physiol. 98, 1290-1297). using dna encoding cyp71a1 as a hybridization probe, we have shown by southern analysis that a related gene is present in the catmint, nepeta racemosa. rna blot analysis, together with western analysis of catmint leaf polypeptides using avocado cyt p-450 antiserum, showed tha ...19947918588
behavioral effects of acute and long-term administration of catnip (nepeta cataria) in mice.catnip or catmint (nepeta cataria) is a plant used extensively to treat human diseases and in toys for pets. we investigated the effects of acute and long-term administration of the plant on some behaviors of mice. the plant was fed as 10% of the normal diet for 2 h/d for 1 or 7 d. acute and long-term dosing increased both rearing and locomotion frequencies observed in an open field. acute exposure to catnip increased stereotyped behavior and susceptibility to seizures, did not interfere with ha ...19958588288
catnip and the alteration of human consciousness.uncertainty exists regarding the ability of catnip (nepeta cataria) to affect human consciousness. we report a case of a toddler exhibiting central nervous system depression after consuming a large quantity of catnip. his obtundation was not attributable to another cause. we review the published literature describing the alleged psychoactive capabilities of catnip and present our case as further information for use in this ongoing controversy.19979397511
the effect of nepeta cataria extract on adherence and enzyme production of staphylococcus aureus.nepeta cataria l., commonly known as catnip, is a perennial herb with a considerable folkloric reputation. a diethyl ether extract of this plant has been shown to have antimicrobial activity against fungi and gram-positive bacteria. the aim of this work was to study the activity of n. cataria extract on 44 staphylococcus aureus strains, some resistant to methicillin, and s. aureus 6538p (american type culture collection) by evaluating the effect of subminimum inhibitory concentrations on coagula ...200111738350
characterization of (1'r,4s,4ar,7s,7ar)-dihydronepetalactol as a semiochemical for lacewings, including chrysopa spp. and peyerimhoffina gracilis.the enantiomerically pure diastereoisomers (1r,4s,4ar,7s,7ar)- (1) and (1r,4r,4ar,7s,7ar)-dihydronepetalactol (2) were synthesized diastereoselectively from a renewable resource, (4as,7s,7ar)-nepetalactone (3), isolated as the main constituent of the essential oil of the catmint plant nepeta cataria. the stereochemistry of the compounds was determined by nmr spectroscopy and x-ray crystallography, and the compounds were identified, respectively, as neomatatabiol and isoneomatatabiol, natural pro ...200212035931
catnip essential oil as a barrier to subterranean termites (isoptera: rhinotermitidae) in the laboratory.the essential oil of catnip, nepeta cataria (lamiacae) was evaluated for behavioral effects on two populations of subterranean termite, reticulitermes flavipes (kollar) and r. virginicus (banks) (isoptera: rhinotermitidae). the catnip essential oil contained approximately 36:64 e,z-nepetalactone and z,e-nepetalactone, respectively. the time to 50% dissipation (dt50) of the isomers in sand was dependent on dose, and ranged from 5.7 to 12.6 d for the e,z-isomer and 7.7-18.6 d for the z,e-isomer. f ...200314503601
feeding deterrent effects of catnip oil components compared with two synthetic amides against aedes aegypti.recently, catnip, nepeta cataria l. (lamiaceae), essential oil has been formulated and marketed as an alternative repellent for protection against biting arthropods by several vendors. we isolated the major active components of catnip oil, e,z- and z,e-nepetalactone, and quantitatively measured their antibiting efficacy compared with the repellents n,n-diethyl-3-methylbenzamide (deet) and chiral (1s,2's)-2-methylpiperidinyl-3-cyclohexene-1-carboxamide (ss220) against the yellowfever mosquito, ae ...200516119554
insecticidal activity of some essential oils against larvae of spodoptera littoralis.thirty-four essential oils were tested for insecticidal activity (fumigation or topical application) against larvae spodoptera littoralis. twenty essential oils applied by fumigation were highly toxic to the third instar of s. littoralis larvae. two essential oils nepeta cataria and thuja occidentalis were highly toxic, with lc50< or =10.0 ml/m3. five essential oils salvia sclarea, thymus mastichina, origanum majorana, pogostemon cablin and mentha pulegium were toxic with lc50 between 10.1 and 2 ...200516236461
the sensilla of aedes and anopheles mosquitoes and their importance in repellency.the aim of this study was to detect the role of some mosquito organs in their sensation of repellent materials. a total of 250 females (15 days old) of the target species aedes aegypti and anopheles stephensi were prepared and divided into five groups: group 1, without antenna; group 2, without maxillary bulbs; group 3, without proboscis; group 4, without frontal tarsus; and group 5, normal females as control. a mixture of five oils containing litsea cubeba 1%, melaleuca leucadendron 1%, melaleu ...200616642383
repellency effect of forty-one essential oils against aedes, anopheles, and culex mosquitoes.since ancient times, plant products were used in various aspects. however, their use against pests decreased when chemical products became developed. recently, concerns increased with respect to public health and environmental security requiring detection of natural products that may be used against insect pests. in this study, 41 plant extracts and 11 oil mixtures were evaluated against the yellow fever mosquito, aedes aegypti (linnaeus), the malaria vector, anopheles stephensi (liston), and th ...200616642384
is the extract from the plant catmint (nepeta cataria) repellent to mosquitoes in australia?the repellency of nepeta cataria (catmint or catnip) was tested against aedes aegypti, ae. vigilax, culex annulirostris, and cx. quinquefasciatus, and compared with a blend of natural plant extracts and n,n-diethyl-3-methylbenzamide (deet) on human skin. the catmint and natural plant extract blend did not provide the same level of protection from biting mosquitoes as deet. there were significant differences in the level of protection provided by catmint to the 4 species of mosquito, with mean pr ...200717939520
the ecological aspect of ethnobotany and ethnopharmacology of population in bosnia and herzegovina.this paper contains first systematical revision of the results on traditional use of wild medicinal and aromatic herbs on the territory of bosnia and herzegovina (b&h)--west of balkan peninsula; southeast of europe. there have been detected 227 plants belonging to 71 different plant families, which are being used with ethno therapeutic purpose. results were obtained by method of open ethno botanical interview which comprised 150 persons, whose average age was 63. medicinal plants in ethno therap ...200718041402
chemical composition and mechanisms underlying the spasmolytic and bronchodilatory properties of the essential oil of nepeta cataria l.the study was aimed to investigate the chemical composition and pharmacological basis for traditional use of essential oil of nepeta cataria l. (limiaceae) (nc.oil) in gastrointestinal and respiratory disorders.200919041706
repellency of hydrogenated catmint oil formulations to black flies and mosquitoes in the field.the essential oil of catmint, nepeta cataria l., was hydrogenated to yield an oil enriched in dihydronepetalactone (dhn) diastereomers, termed. this material was used for the preparation of liquid alcohol-based and lotion formulations. the efficacy of these formulations as repellents was tested after application to human test subjects at two locations in the united states: maine and florida. in maine, data on repellency of the hydrogenated catmint oil formulations toward black flies (simulium de ...200819058632
behavioral responses of catnip (nepeta cataria) by two species of mosquitoes, aedes aegypti and anopheles harrisoni, in thailand.an investigation of the biological effect of catnip oil (nepeta cataria l.) on the behavioral response of field collected aedes aegypti and anopheles harrisoni was conducted using an automated excitorepellency test system. aedes aegypti showed significantly higher escape rates from the contact chamber at 5% catnip oil compared to other concentrations (p < 0.05). with anopheles harrisoni, a high escape response was seen at 2.5% catnip oil from the contact chamber, while in the noncontact chamber ...200819181058
antimicrobial and antioxidant activity of the essential oil and methanol extract of nepeta cataria.catnip (nepeta cataria) is an important medicinal herb belonging to the mint family, lamiaceae. in this study, the in vitro antimicrobial and antioxidant activities of the essential oil and methanol extract from nepeta cataria, and its essential oil composition were investigated. the essential oil, which has 4aalpha,7alpha,7abeta-nepetalactone (70.4%), 4aalpha,7alpha,7abeta-nepetalactone (6.0%), thymol (2.3%), and 4aalpha,7alpha, 7abeta3-nepetalactone (2.5%), as main components, exhibited activi ...200919469289
dihydronepetalactones deter feeding activity by mosquitoes, stable flies, and deer ticks.the essential oil of catmint, nepeta cataria l., contains nepetalactones, that, on hydrogenation, yield the corresponding dihydronepetalactone (dhn) diastereomers. the dhn diastereomer (4r,4ar,7s,7as)-4,7-dimethylhexahydrocyclopenta[c]pyran-1(3h)-one, dhn 1) was evaluated as mosquito repellent, as was the mixture of diastereomers {mostly (4s,4ar,7s,7ar)-4,7-dimethylhexahydrocyclopenta[c]pyran-1(3h)-one, dhn 2} present after hydrogenation of catmint oil itself. the repellency of these materials t ...200919645285
efficacy and safety of catnip (nepeta cataria) as a novel filth fly repellent.catnip (nepeta cataria) is known for its pseudo-narcotic effects on cats. recently, it has been reported as an effective mosquito repellent against several aedes and culex species, both topically and spatially. our laboratory bioassays showed that catnip essential oil (at a dosage of 20 mg) resulted in average repellency rates of 96% against stable flies, stomoxys calcitrans (l.) and 79% against houseflies, musca domestica (l.), respectively. this finding suggested that the application of repell ...200919712151
repellent activity of catmint, nepeta cataria, and iridoid nepetalactone isomers against afro-tropical mosquitoes, ixodid ticks and red poultry mites.the repellent activity of the essential oil of the catmint plant, nepeta cataria (lamiaceae), and the main iridoid compounds (4as,7s,7ar) and (4as,7s,7as)-nepetalactone, was assessed against (i) major afro-tropical pathogen vector mosquitoes, i.e. the malaria mosquito, anopheles gambiae s.s. and the southern house mosquito, culex quinquefasciatus, using a world health organisation (who)-approved topical application bioassay (ii) the brown ear tick, rhipicephalus appendiculatus, using a climbing ...201021056438
nepetalactones from essential oil of nepeta cataria represent a stable fly feeding and oviposition repellent.the stable fly, stomoxys calcitrans (l.) (diptera: muscidae), is one of the most serious pests to livestock. it feeds mainly on cattle and causes significant economic losses in the cattle industry. standard stable fly control involving insecticides and sanitation is usually costly and often has limited effectiveness. as we continue to evaluate and develop safer fly control strategies, the present study reports on the effectiveness of catnip (nepeta cataria l.) oil and its constituent compounds, ...201121781140
nepeta cataria l. var. citriodora (becker) increases penile erection in rats.nepeta cataria (nc), catnip, induces pleasure in cats and humans.201121843621
the effect of natural mulches on crop performance, weed suppression and biochemical constituents of catnip and st. john's wort.because of expanding markets for high-value niche crops, opportunities have increased for the production of medicinal herbs in the usa. an experiment was conducted in 2001 and 2002 near gilbert, ia, to study crop performance, weed suppression, and environmental conditions associated with the use of several organic mulches in the production of two herbs, catnip (nepeta cataria l.) and st. john's wort (hypericum perforatum l. 'helos'). treatments were arranged in a completely randomized design and ...200417047728
evaluation of a push-pull approach for aedes aegypti (l.) using a novel dispensing system for spatial repellents in the laboratory and in a semi-field environment.the increase in insecticide resistant mosquito populations necessitates the exploration of novel vector control intervention measures. push-pull strategies for insect control have been successful when used in integrated crop pest management. through the combinatory use of deterring and attracting stimuli, the abundance of insect pests can be changed in a given area. a push-pull strategy might also significantly reduce human-vector contacts and augment existing mosquito control strategies, e.g. t ...201526115365
responsiveness of cats (felidae) to silver vine (actinidia polygama), tatarian honeysuckle (lonicera tatarica), valerian (valeriana officinalis) and catnip (nepeta cataria).olfactory stimulation is an often overlooked method of environmental enrichment for cats in captivity. the best known example of olfactory enrichment is the use of catnip, a plant that can cause an apparently euphoric reaction in domestic cats and most of the pantherinae. it has long been known that some domestic cats and most tigers do not respond to catnip. although many anecdotes exist of other plants with similar effects, data are lacking about the number of cats that respond to these plants ...201728302120
natural products useful in respiratory disorders: focus on side-effect neutralizing combinations.this review summarizes literature related to medicinal plants reputed in traditional medical systems for treatment of asthma and coughs. the plants that are pharmacologically investigated for their effectiveness in such conditions, along with respective experimental protocol details, are also discussed. some of plant origin compounds, which are considered useful as antitussive and antiasthmatic agents, are described as well. chrysoeriol, a constituent of aspalathus linearis (fabaceae) was observ ...201526061992
behavioral activity of catnip (lamiaceae) essential oil components to the german cockroach (blattodea: blattellidae).the essential oil of catnip, nepeta cataria l., contains two isomers of nepetalactone, e,z-and z,e-nepetalactone, and was tested for repellent activity to adult male german cockroaches, blattella germanica (l.), in a choice-test arena. the two isomers of nepetalactone were purified by using preparative thin-layer chromatography and tested for behavioral activity in the choice-test arena. significant differences due to concentration were detected by analysis of variance, and the responses were co ...200212020017
efficacy and longevity of newly developed catnip oil microcapsules against stable fly oviposition and larval growth.the stable fly, stomoxys calcitrans (diptera: muscidae), is one of the most important pests of cattle and costs u.s. cattle producers billions of dollars in losses annually. in this study, the efficacy of catnip oil encapsulated in gelatin in oviposition deterrence and larval growth inhibition in stable flies was examined under laboratory conditions. more than 98% inhibition of stable fly larval growth and female oviposition was observed in larval and oviposition media treated with encapsulated ...201424111783
genotoxic effects of catmint (nepeta meyeri benth.) essential oils on some weed and crop plants.this study investigates the genotoxicity of the essential oils extracted from the aerial parts of catmint (nepeta meyeri benth.) against two weeds (bromus danthoniae and lactuca serriola) and two crop plants (brassica napus and zea mays). the essential oils of n. meyeri analyzed by gas chromatography-mass spectrometry contained 14 compounds, with 4aα, 7α, 7aβ-nepetalactone (83.4%), 4aα, 7α, and 7aα-nepetalactone (8.83%) as the major components. the oils were diluted (25, 50, 100, and 150 ppm) an ...201322434692
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