the inhibitory effect of rosmarinic acid on complement involves the c5 convertase.rosmarinic acid (ra), a naturally occurring extract from melissa officinalis, inhibits several complement-dependent inflammatory processes and may have potential as a therapeutic agent for the control of complement activation in disease. rosmarinic acid has been reported to have effects on both the classical pathway c3-convertase and on the cobra venom factor-induced, alternative pathway convertase. in order to define the mechanism of inhibition, the effect of ra on classical and alternative pat ...19911761351
[comparative studies of the sensitizing capacity of drugs used in herpes simplex].experimental sensitization of guinea pigs with 9 commonly used or still tested antiviral drugs revealed a very low sensitizing power for these when compared with tromantadine. in a former investigation tromantadine had been shown to be a moderate sensitizer. while ethoxyuridine, bromovinyl deoxyuridine and phosphono formiate gave no response in the animals, aciclovir, vidarabine, idoxuridine, trifluorothymidine, proclu and an extract of lemon balm (melissa officinalis) only induced weak reaction ...19862949957
antiviral substances in plants of the mint family (labiatae). i. tannin of melissa officinalis. 19674290277
antiviral substances in plants of the mint family (labiatae). ii. nontannin polyphenol of melissa officinalis. 19674290452
studies on substances of plant origin with anticipated cyto- and oncostatic activity. part 1: the influence of water extracts from melissa officinalis on the protein biosynthesis in vitro. 19846531382
antimicrobial activity of essences from labiates.bacteria, filamentous fungi and yeasts were subjected to the action of lavandula officinalis, melissa officinalis and rosmarinus officinalis essences in a steam phase, using a microatmospheric technique. due to the methodology employed, l. officinalis essence was more active in filamentous fungi than the other essential oils studied. all three essences possessed a similar degree of activity against the micro-organisms tested, though a relatively higher activity was seen in the case of m. officin ...19957630324
antiherpes effect of melissa officinalis l. extracts.studies were carried out on the virucidal and antiviral effects of melissa officinalis l. extracts (m1, m3, m3 and m4) with respect to herpes simplex virus type 1 (hsv-1). virucidal effect was registered within 3 and 6 hours of treatment using m4 administered in mtc. the remaining extracts inactivate the virus at the 12th and 24th hour. no significant values of inhibiting activity of m1, m2, and m3 on the same virus in vitro or in vivo were demonstrated. the presence of caffeic, rosmarinic and f ...19938390134
protective effects of the aerial parts of salvia officinalis, melissa officinalis and lavandula angustifolia and their constituents against enzyme-dependent and enzyme-independent lipid peroxidation.the antioxidant effects of aqueous methanolic extracts from three medicinal lamiaceae species were investigated in enzyme-dependent and enzyme-independent lipid peroxidation systems. all these extracts caused a considerable concentration-dependent inhibition of lipid peroxidation. phenolic components present in the plant extracts were evaluated for antioxidant activity and were found effective in both tests. their concentrations in each extract were determined by tlc-densitometry.199910532875
in vitro effect of essential oils and isolated mono- and sesquiterpenes on leishmania major and trypanosoma brucei.the effect of different essential oils as well as of isolated mono- and sesquiterpenes on the viability of bloodstream forms of trypanosoma brucei, promastigotes of leishmania major and human hl-60 cells was evaluated using the almar blue assay. of the 12 essential oils and 8 terpenes investigated, only three essential oils, melissa officinalis (balmmint) oil, thymus vulgaris (thyme) oil, and melaleuca alternifolia (tea tree) oil were about 50-fold and 80-fold more toxic to bloodstream forms of ...200010865458
activity of essential oils from mediterranean lamiaceae species against food spoilage yeasts.the essential oils from aerial parts of melissa officinalis, lavandula angustifolia, salvia officinalis, and mentha piperita were analyzed by gas chromatography and gas chromatography-mass spectrometry. their antimicrobial activities were evaluated against five food spoilage yeasts, torulaspora delbrueckii, zygosaccharomyces bailii, pichia membranifaciens, dekkera anomala, and yarrowia lipolytica. saccharomyces cerevisiae was also used as a reference. the oils were preliminarily screened by a di ...200312696686
antibacterial activity of medicinal plant extracts against periodontopathic bacteria.this study was performed to evaluate the antibacterial activity of althaea officinalis l. roots, arnica montana l. flowers, calendula officinalis l. flowers, hamamelis virginiana l. leaves, illicium verum hook. fruits and melissa officinalis l. leaves, against anaerobic and facultative aerobic periodontal bacteria: porphyromonas gingivalis, prevotella spp., fusobacterium nucleatum, capnocytophaga gingivalis, veilonella parvula, eikenella corrodens, peptostreptococcus micros and actinomyces odont ...200312820224
relaxant effect of essential oil of melissa officinalis and citral on rat ileum contractions.the relaxant effect of the essential oil of melissa officinalis and its main component, citral, on rat isolated ileum contractions was evaluated. m. officinalis essential oil (moeo) inhibited the response to kcl (80 mm), ach (320 nm) and 5-ht (1.28 microm) in a concentration-dependent manner with a ic(50) of approximately 20 ng/ml. citral also had a concentration-dependent inhibitory effect on contraction of rat ileum with ic(50)s comparable to that of moeo.200312837359
antiviral activity of melissa officinalis (lemon balm) extract. 196414233461
in vitro assay of thyroid disruptors affecting tsh-stimulated adenylate cyclase activity.several natural or synthetic chemicals have been indicated as potential thyroid disruptors. the development of in vitro assays has been recommended to comprehensively assess the potential thyroid disrupting activity of a substance or a complex mixture. in this study, 12 substances suspected for acting as thyroid disruptors were tested for their ability to inhibit tsh-stimulated camp production in vitro. those substances producing an inhibition were further studied to establish the level at which ...200314759065
antimicrobial and antioxidant activities of melissa officinalis l. (lamiaceae) essential oil.the present study describes antimicrobial and free radical scavenging capacity (rsc) together with the effects on lipid peroxidation (lp) of melissa officinalis essential oil. the chemical profile of essential oil was evaluated by the means of gas chromatography-mass spectrometry (gc-ms) and thin-layer chromatography (tlc). rsc was assessed measuring the scavenging activity of essential oil on the 2,2-diphenyl-1-picrylhydrazyl (dpph(*)) and oh(*) radicals. the effect on lp was evaluated followin ...200415113145
traditional medicine in sakarya province (turkey) and antimicrobial activities of selected species.traditional medicine in north-west of turkey (sakarya province) were studied during a 2 months field study by interviewing local informants from several villages. plant species used to treat infections were tested for antimicrobial activity. information was collected for 46 plant species from 30 families and for 5 animal species. twenty four of the plant species were cultivated. most used families were asteraceae, cucurbitaceae, lamiaceae and rosaceae and the most used plants were artemisia absi ...200415507351
antiviral activity of the volatile oils of melissa officinalis l. against herpes simplex virus type-2.melissa officinalis l. (lamiaceae) has been used in a variety of practical applications in medical science. our objective in the current study was to determine the effects of the volatile oil components of m. officinalis on herpes simplex virus type 2 (hsv-2) replication in hep-2 cells. four different concentrations (25, 50, 100, 150 and 200 microg/ml) of volatile oils were examined. experiments were carried out using hep-2 cells. m. officinalis volatile oil was found to be non-toxic to hep-2 ce ...200415636181
screening of traditionally used lebanese herbs for neurological the recent decades the use of traditional medicine in lebanon has increased. aqueous, ethanol and ethyl acetate extracts of seven lebanese plants that are used traditionally for neurological disorders as alzheimer's disease, epilepsy and affective disorders as depression were tested for inhibition of acetylcholinesterase and affinity to the gaba(a)-benzodiazepine site and to the serotonin transporter. ethyl acetate extracts of salvia triloba, lavandula officinalis, origanum syriacum and artem ...200415652288
citral is a new inducer of caspase-3 in tumor cell lines.citral, 3,7-dimethyl-2,6-octadien-1-al, a key component of the lemon-scented essential oils extracted from several herbal plants such as lemon grass (cymbopogon citratus), melissa (melissa officinalis), verbena (verbena officinalis) is used as a food additive and as a fragrance in cosmetics. in this study, we investigated the anti-cancer potential of citral and its mode of action. concentrations of 44.5 mum, comparable to the concentration of citral in a cup of tea prepared from 1 g of lemon gra ...200515931590
protective role of melissa officinalis l. extract on liver of hyperlipidemic rats: a morphological and biochemical this study, the effects of melissa officinalis l. extract on hyperlipidemic rats were investigated, morphologically and biochemically. the animals were fed a lipogenic diet consisting of 2% cholesterol, 20% sunflower oil and 0.5% cholic acid added to normal chow and were given 3% ethanol for 42 days. the plant extract was given by gavage technique to rats to a dose of 2 g/kg every day for 28, 14 days after experimental animals done hyperlipidemia. the degenerative changes were observed in hyp ...200515946812
neurobehavioral and genotoxic aspects of rosmarinic acid.rosmarinic acid is a naturally occurring hydroxylated compound. it is present in many plants, for example, it occurs in artemisia capillaris, calendulla officinalis, melissa officinalis, salvia officinalis and in other several plant families. it also shows a number of interesting biological activities, e.g. antiviral, antibacterial, antiinflammatory and antioxidant. the aim of the present study was to investigate the effect of the i.p. administration of rosmarinic acid (1, 2, 4 or 8 mg kg(-1)) o ...200516026713
bacterial colonization of the phyllosphere of mediterranean perennial species as influenced by leaf structural and chemical this study, we assessed various leaf structural and chemical features as possible predictors of the size of the phyllosphere bacterial population in the mediterranean environment. we examined eight perennial species, naturally occurring and coexisting in the same area, in halkidiki (northern greece). they are arbutus unedo, quercus coccifera, pistacia lentiscus, and myrtus communis (evergreen sclerophyllous species), lavandula stoechas and cistus incanus (drought semi-deciduous species), and ...200516215646
insecticidal activity of some essential oils against larvae of spodoptera littoralis.thirty-four essential oils were tested for insecticidal activity (fumigation or topical application) against larvae spodoptera littoralis. twenty essential oils applied by fumigation were highly toxic to the third instar of s. littoralis larvae. two essential oils nepeta cataria and thuja occidentalis were highly toxic, with lc50< or =10.0 ml/m3. five essential oils salvia sclarea, thymus mastichina, origanum majorana, pogostemon cablin and mentha pulegium were toxic with lc50 between 10.1 and 2 ...200516236461
in vitro susceptibility of helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders.the gram-negative bacterium helicobacter pylori (hp), identified in 1982, is now recognized as the primary etiological factor associated with the development of gastritis and peptic ulcer disease. in addition, hp infections are also associated with chronic gastritis, gastric carcinoma and primary gastric b-cell lymphoma. for centuries, herbals have been used in traditional medicine to treat a wide range of ailments, including gastrointestinal (gi) disorders such as dyspepsia, gastritis and pepti ...200516317658
larvicidal activity of some labiatae (lamiaceae) plant extracts from turkey.ethanol extracts of the aerial parts from five labiatae (lamiaceae) species, obtained from antalya, turkey, were tested for larvicidal activity against the house mosquito culex pipiens l. (diptera: culicidae) under laboratory conditions. third and fourth instar mortality from six concentrations (5, 10, 25, 50, 100 and 200 ppm) of each plant extract were compared against the organophosphorus insecticide, temephos which is currently used for larval control. all plant extracts showed high larvicida ...200617009204
antiviral effect of aqueous extracts from species of the lamiaceae family against herpes simplex virus type 1 and type 2 in vitro.aqueous extracts from species of the lamiaceae family were examined for their antiviral activity against herpes simplex virus (hsv). extracts from lemon balm (melissa officinalis), peppermint (mentha x piperita), prunella (prunella vulgaris), rosemary (rosmarinus officinalis), sage (salvia officinalis) and thyme (thymus vulgaris) were screened. their inhibitory activity against herpes simplex virus type 1 (hsv-1), type 2 (hsv-2) and an acyclovir-resistant strain of hsv-1 (acv (res)) was tested i ...200617091431
the cupric ion reducing antioxidant capacity and polyphenolic content of some herbal teas.the total antioxidant capacity of the aqueous extracts of some endemic herbs-prepared as infusions by steeping these herbs in hot water--was assayed with bis(neocuproine)copper(ii) chloride, also known as the cupric ion reducing antioxidant capacity (cuprac) reagent, which was easily accessible, rapid, stable and responsive to both hydrophilic and lipophilic antioxidants. the highest antioxidant capacities of some herbal teas available in the turkish market were observed for scarlet pimpernel (a ...200617135020
medicinal plants used in kirklareli province (turkey).in this paper, 126 traditional medicinal plants from kirklareli province in turkey have been reported. one hundred and twenty six plant species belonging to 54 families and among them 100 species were wild and 26 species were cultivated plants. most used families were rosaceae, labiatae, compositae and the most used plants were cotinus coggyria, sambucus ebulus, achillea millefolium subsp. pannonica, hypericum perforatum, matricaria chamomilla var. recutita, melissa officinalis subsp. officinali ...200717257791
ethnoveterinary medicines used for ruminants in british columbia, canada.the use of medicinal plants is an option for livestock farmers who are not allowed to use allopathic drugs under certified organic programs or cannot afford to use allopathic drugs for minor health problems of livestock.200717324258
effects of the herbal formulation colimil on upper gastrointestinal transit in mice in vivo.clinical evidence suggests that the herbal formulation colimil (which contains matricaria recutita flowers extract, foeniculum vulgare fruit extract and melissa officinalis aerial parts extract) is effective in the treatment of breastfed colic in infants. therefore the effect of this phytotherapeutic formulation and its herbal constituents on upper gastrointestinal transit was investigated in mice in vivo. oral administration of the herbal formulation (0.4-0.8 ml/mice) dose-dependently delayed u ...200717582592
ethnoveterinary medicines used to treat endoparasites and stomach problems in pigs and pets in british columbia, canada.this paper documents the medicinal plants used to treat endoparasites and stomach problems in dogs, cats and pigs in british columbia, canada. ethnoveterinary data was collected over a 6-month period in 2003. the majority of the information on pets came from 2 naturopaths, 10 herbalists, 5 dog trainers, breeders and pet shop owners, 9 holistic veterinarians and 6 of 27 organic farmers. two pig farmers joined the study in the final stages. the following plants were used as anthelmintics: artemisi ...200717628343
in vitro antioxidant and anti-rhizopus activities of lamiaceae herbal extracts.eighty-eight extracts of different polarity obtained from 18 lamiaceae medicinal and aromatic plants were screened for their antioxidant and antifungal properties. a tlc analysis combined with two bioassays were used to detect these activities. in most cases the highest radical scavenger capacity was detected in methanolic and aqueous extracts and polyphenols may be responsible. the most interesting antioxidant activity was observed in polar extracts obtained from lycopus europaeus, melissa offi ...200717912643
regulation of obesity and lipid disorders by herbal extracts from morus alba, melissa officinalis, and artemisia capillaris in high-fat diet-induced obese mice.melissa officinalis l. (labiatae), morus alba l. (moraceae), and artemisia capillaris thunb. (compositae) are suggested to be involved in the regulation of hyperlipidemia. we hypothesized that ob-x, a mixture of three herbs, morus alba, melissa officinalis and artemisia capillaris [corrected] improves lipid metabolism, body weight gain and adiposity and that peroxisome proliferator-activated receptor alpha (pparalpha) is associated with these events. mice fed a high-fat diet for 12 weeks exhibit ...200818023310
aqueous extracts from peppermint, sage and lemon balm leaves display potent anti-hiv-1 activity by increasing the virion density.aqueous extracts from leaves of well known species of the lamiaceae family were examined for their potency to inhibit infection by human immunodeficiency virus type 1 (hiv-1).200818355409
[advances on the effects of the compounds of a phytotherapic agent (colimil) on upper gastrointestinal transit in mice].phytotherapic agents, such as herbal formulations containing matricariae recutita flowers (chamomile) extract, foeniculum vulgare fruit (fennel) extract and melissa officinalis aerial parts (lemon balm) extract have beneficial effects on gastrointestinal tract in colicky infants. however, the mechanism is largely unexplored and, particularly, it is not clear if it affects intestinal motility. the aim of this experimental study was to evaluate the effect of different herbal formulations containin ...200818487975
medicinal plant treatments for fleas and ear problems of cats and dogs in british columbia, canada.research conducted in 2003/2004 documented and validated (in a non-experimental way) ethnoveterinary medicines used by small-scale, organic livestock farmers in british columbia (bc), canada. interviews were conducted with 60 participants who were organic farmers or holistic medicinal/veterinary practitioners. a workshop was held with selected participants to discuss the plant-based treatments. this paper reports on the medicinal plants used for fleas in cats and dogs. fleas and flies are treate ...200818563443
melissa officinalis oil affects infectivity of enveloped herpesviruses.extracts and essential oils of medicinal plants are increasingly of interest as novel drugs of antimicrobial and antiviral agents, since herpes simplex virus (hsv) might develop resistance to commonly used antiviral agents. melissa officinalis essential oil was phytochemically examined by gc-ms analysis, its main constituents were identified as monoterpenaldehydes citral a, citral b and citronellal. the antiviral effect of lemon balm oil, the essential oil of melissa officinalis, on herpes simpl ...200818693101
activity of essential oils and individual components against acetyl- and butyrylcholinesterase.we have tested acetylcholinesterase (ache) and butyrylcholinesterase (bche) inhibitory activities of nineteen essential oils obtained from cultivated plants, namely one from anethum graveolens l. (organic fertilizer), two from foeniculum vulgare mill. collected at fully-mature and flowering stages (organic fertilizer), two from melissa officinalis l. (cultivated using organic and chemical fertilizers), two from mentha piperita l. and m. spicata l. (organic fertilizer), two from lavandula officin ...200818810999
inhibitory activity of melissa officinalis l. extract on herpes simplex virus type 2 replication.melissa officinalis l. (lamiaceae) (lemon balm) is used in folk medicine for nervous complaints, lower abdominal disorders and, more recently, for treating herpes simplex lesions. in this work the antiviral activity of a hydroalcoholic extract of lemon balm leaves against the herpes simplex virus type 2 (hsv-2) was assessed by the cytopathic effect inhibition assay on vero cells (atcc ccl-81), in comparison with acyclovir. the cytotoxicity of the extract on vero cells was previously tested by ev ...200819023806
appraisal of scopolamine-induced antiamnesic effect in mice and in vitro antiacetylcholinesterase and antioxidant activities of some traditionally used lamiaceae plants.salvia species and melissa officinalis are used for their memory-enhancing effects in european folk medicine. teucrium polium was reported to be used in anatolia for memory-enhancement in a very old book written by an ottoman herbalist-physician.200919162154
bioassay-guided fractionation of lemon balm (melissa officinalis l.) using an in vitro measure of gaba transaminase activity.a novel pharmacological mechanism of action for the anxiolytic botanical melissa officinalis l. (lemon balm) is reported. the methanol extract was identified as a potent in vitro inhibitor of rat brain gaba transaminase (gaba-t), an enzyme target in the therapy of anxiety, epilepsy and related neurological disorders. bioassay-guided fractionation led to the identification and isolation of rosmarinic acid (ra) and the triterpenoids, ursolic acid (ua) and oleanolic acid (oa) as active principles. ...200919165747
mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of melissa officinalis (lemon balm) in mice.the present study examined the antinociceptive effect of the ethanolic extract from melissa officinalis l. and of the rosmarinic acid in chemical behavioral models of nociception and investigates some of the mechanisms underlying this effect. the extract (3-1000 mg/kg), given orally (p.o.) 1 h prior to testing, produced dose-dependent inhibition of acetic acid-induced visceral pain, with id50 value of 241.9 mg/kg. in the formalin test, the extract (30-1000 mg/kg, p.o.) also caused significant in ...200919358864
chemical compositions and antioxidant properties of essential oils from nine species of turkish plants obtained by supercritical carbon dioxide extraction and steam distillation.chemical compositions and antioxidant activities of essential oils from nine different species of turkish plants, namely melissa officinalis l., rosmarinus officinalis l., cuminum cyminum l., piper nigrum l., lavandula stoechas spp., foeniculum vulgare, pimpinella anisum l., thymus serpyllum and liquidamber orientalis mill., were studied. essential oils were obtained by supercritical carbon dioxide (scco2) extraction and steam distillation, and were analyzed by gas chromatography-mass spectromet ...200819382349
composition of the fresh leaves and stems of melissa officinalis and evaluation of skin irritation in a reconstituted human epidermis model.the composition of a centrifuged product obtained from the fresh leaves and stems of melissa officinalis and skin irritation in the reconstituted human epidermis (episkin model) have been investigated in comparison to the etoh-h(2)o (1:1) extract obtained by soxhlet from the dried plant. two new sulfated triterpenes (1 and 2) and two ionol derivatives have been isolated for the first time from melissa officinalis together with caffeic and rosmarinic acids. the structures of compounds 1 and 2 wer ...200919653667
endothelium-dependent induction of vasorelaxation by melissa officinalis l. ssp. officinalis in rat isolated thoracic the current study, vasorelaxant effect produced by the aqueous extract of melissa officinalis l. ssp. officinalis (moo) (lamiaceae) and its possible mechanism in isolated rat aortic rings precontracted with phenylephrine were examined. in the first series of experiments, effect of moo on the baseline and phenylephrine (10(-5)m) precontracted arteries was investigated, while in the second group of experiments, endothelium intact or endothelium denuded effect was determined. the agents used wer ...200818606529
formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: relarian.dietary supplements are widely used for desired effects on memory, insomnia, mood and anxiety. this review focuses on supplements which have anxiolytic or mild relaxation properties and enhance mood. for example, kava (piper methysticum) is reported to have anaxiolytic actions and to reduce tension through skeletal muscle relaxation. dried passion flower (genus passiflora) is reported to reduce insomnia and hysteria. skullcap (genus scutellaria), hops (humulus lupulus), lemon balm (melissa offic ...200919865069
anthelmintic effects of phytogenic feed additives in ascaris suum inoculated pigs.two experiments were performed to determine the anthelmintic effect of some phytogenic feed additives on a mild infection of ascaris suum in growing and finishing pigs. usually, an infection of a. suum is controlled by using conventional synthetic drugs. organic farmers, however, prefer a non-pharmaceutical approach to worm control. therefore, phytotherapy could be an appropriate alternative. in the first experiment, a commercial available organic starter diet was supplemented with 3% of a herb ...201019954891
effects of chronic administration of melissa officinalis l. extract on anxiety-like reactivity and on circadian and exploratory activities in mice.this study aimed to determine the effects of chronic (15 consecutive days of treatment) per os administration of melissa officinalis l. extract (cyracos, naturex) on anxiety-like reactivity in mice. as measured by hplc, cyracos contains significant amounts of rosmarinic acid and the triterpenoids oleanolic acid and ursolic acid, which inhibit gamma-aminobutyric acid transaminase (gaba-t) activity and increase gaba levels in the brain (awad et al., 2007; awad et al., 2009). thus, we evaluated cyr ...201020171069
therapeutic effects on murine oral candidiasis by oral administration of cassia (cinnamomum cassia) preparation.we examined the effects of spices and herbs on candida albicans growth using in vitro assay and therapeutic activity of some selected herbal preparations against murine oral candidiasis. all tested samples: lemongrass (cymbopogon citratus), lemon balm (melissa officinalis), thyme (thymus vulgaris), rosemary (rosmarinus officinalis), roselle (hibiscus sabdariffa), green tea (camellia sinensis), and cassia (cinnamomum cassia) inhibited candida mycelial growth in vitro. the results of this assay sh ...201020185867
chemical composition and in vitro antimicrobial activity of essential oil of melissa officinalis l. from romania.melissa officinalis l. (lemon balm) is used in traditional medicine to treat insomnia, anxiety, gastric conditions, psychiatric conditions, migraines, hypertension and bronchial conditions. natural essential oils (mixtures of fragrant chemical) obtained from various parts of plants are efficient active antimicrobial agents. the widespread use of antimicrobial agents selects resistant bacterial strains, which seriously compromise the effectiveness of antibiotic treatment. the use of herbal medici ...200820201279
selenium, iodine, omega-3 pufa and natural antioxidant from melissa officinalis l.: a combination of components from healthier dry fermented sausages formulation.a new formulation of dry fermented sausage, including ingredients that improve the nutritional and health benefits of this type of product is presented. se yeast (2g/kg), iodized salt (26g/kg), linseed:algae (3:2) emulsion (62.5g/kg), and lyophilized water extract of melissa officinalis l. as a source of natural antioxidants (686mg/kg), yielded dry fermented sausages with technological and sensory properties similar to traditional ones. from the nutritional standpoint, a 50g portion of this prod ...201020374898
chemical composition and larvicidal evaluation of mentha, salvia, and melissa essential oils against the west nile virus mosquito culex pipiens.the volatile metabolites of wild-growing mentha spicata, m. longifolia, m. suaveolens, melissa officinalis, salvia fruticosa, s. pomifera subsp. calycina, and s. pomifera subsp. pomifera from greece were determined by gas chromatography and gas chromatography-mass spectrometry. the insecticidal properties of the analyzed essential oils were screened on culex pipiens larvae. additionally two of the main components of the essential oils, piperitenone oxide and 1,8-cineole were assayed against c. p ...201020405142
anti-diabetic effects of lemon balm ( melissa officinalis) essential oil on glucose- and lipid-regulating enzymes in type 2 diabetic mice.the antioxidant activity of lemon balm (melissa officinalis) essential oil (lbeo) on 2,2-diphenyl-1-picrylhydrazyl (dpph) radicals and its hypoglycaemic effect in db/db mice were investigated. lbeo scavenged 97 % of dpph radicals at a 270-fold dilution. mice administered lbeo (0.015 mg/d) for 6 weeks showed significantly reduced blood glucose (65 %; p < 0.05) and tag concentrations, improved glucose tolerance, as assessed by an oral glucose tolerance test, and significantly higher serum insulin ...201020487577
assessment of the antioxidant potential of selected plant extracts--in vitro and in vivo experiments on pork.the antioxidant potential of selected plant extracts was assessed in vitro and in vivo experiments on pork. in the in vitro experiment, the anti-oxidative capacity of ethanol-water extract of melissa officinalis (mw), ethanol-propylene-glycol extracts of m. officinalis (mp), origanum vulgaris (o) and salvia officinalis (s) at different dilutions was analysed. furthermore a 2% essential oil concentrate was added to origanum (osi) and salvia (ssi). in the two in vivo experiments in total 104 slova ...201020488625
enzymes of phenylpropanoid metabolism in the important medicinal plant melissa officinalis l.lemon balm (melissa officinalis, lamiaceae) is a well-known medicinal plant. amongst the biologically active ingredients are a number of phenolic compounds, the most prominent of which is rosmarinic acid. to obtain better knowledge of the biosynthesis of these phenolic compounds, two enzymes of the general phenylpropanoid pathway, phenylalanine ammonia-lyase (pal) and 4-coumarate:coenzyme a-ligase (4cl), were investigated in suspension cultures of lemon balm. mopal1 and mo4cl1 cdnas were cloned ...201020563822
phytotoxic activities of mediterranean essential oils.twelve essential oils from mediterranean aromatic plants were tested for their phytotoxic activity, at different doses, against the germination and the initial radicle growth of seeds of raphanus sativus, lactuca sativa and lepidium sativum. the essential oils were obtained from hyssopus officinalis, lavandula angustifolia, majorana hortensis, melissa officinalis, ocimum basilicum, origanum vulgare, salvia officinalis and thymus vulgaris (lamiaceae), verbena officinalis (verbenaceae), pimpinella ...201020657443
phenolic composition and antioxidant properties of some traditionally used medicinal plants affected by the extraction time and hydrolysis.polyphenolic phytochemicals in traditionally used medicinal plants act as powerful antioxidants, which aroused an increasing interest in their application in functional food development.201120848396
an attempt of postharvest orange fruit rot control using essential oils from mediterranean plants.twelve essential oils from mediterranean aromatic plants were tested at different doses against four fungi known as causal agents of post-harvest orange fruit rot: botrytis cinerea, penicillium italicum, phytophthora citrophthora, and rhizopus stolonifer. essential oils were obtained from hyssopus officinalis, lavandula angustifolia, majorana hortensis, melissa officinalis, ocimum basilicum, origanum vulgare, salvia officinalis, and thymus vulgaris (family lamiaceae), verbena officinalis (family ...201020874226
effects of melissa officinalis l. (lemon balm) extract on neurogenesis associated with serum corticosterone and gaba in the mouse dentate gyrus.lemon balm, leaves of melissa officinalis l., has been used for anti-anxiety and spasmolytics. we observed the extract of melissa officinalis l. (moe) on cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus (dg) of middle-aged mice (12 months of age) using ki67 and doublecortin (dcx), respectively. we also observed changes in corticosterone, gad67 and gaba-transaminase (gaba-t) to check their possible mechanisms related to neurogenesis. we administered 50 or 200 mg/ ...201021076869
evaluation of two natural extracts (rosmarinus officinalis l. and melissa officinalis l.) as antioxidants in cooked pork patties packed in map.two natural extracts, from rosemary (rosmarinus officinalis l.; nutrox) and lemon balm (melissa officinalis l.; meliox) showing a potential antioxidant activity, have been evaluated and compared with a synthetic antioxidant (butylated hydroxytoluene; bht) and a control batch. pork meat patties were made by addition of the mentioned compounds, cooked and packed in modified atmosphere and stored under illumination for 6 days. a descriptive sensory analysis was also conducted. the patties with natu ...201121345605
cloning and characterisation of rosmarinic acid synthase from melissa officinalis l.lemon balm (melissa officinalis l.; lamiaceae) is a well-known medicinal plant mainly due to two groups of compounds, the essential oil and the phenylpropanoid derivatives. the prominent phenolic compound is rosmarinic acid (ra), an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid. ra shows a number of interesting biological activities. rosmarinic acid synthase (ras; 4-coumaroyl-coa:hydroxyphenyllactic acid hydroxycinnamoyltransferase) catalyses the ester formation. cell cultures of m. o ...201121354582
microbiological and toxicological quality of dried herbs.the microbiological and toxicological quality of 51 samples of dried herbs (melissa officinalis, salvia officinalis, malva sylvestris, matricaria chamomilla, alchemilla vulgaris and centaurea cyanus) cultivated in family-managed farms in molise region (italy) was evaluated.201121375549
inhibitory effects of 16-hydroxy-9-oxo-10e,12e,14e-octadecatrienoic acid (corchorifatty acid b) isolated from melissa officinalis linné on melanogenesis.16-hydroxy-9-oxo-10e,12e,14e-octadecatrienoic acid, also known as corchorifatty acid b (cfab), is isolated from the ethanol extracts of the aerial parts of melissa officinalis linné (labiatae) and exhibits inhibitory effects on cellular pigmentation in both human melanocytes and mouse melanoma b16 cells. cfab specifically decreases cellular melanin by most likely inducing rapid degradation of tyrosinase in b16 cells. interestingly, unlike other reagents that promote degradation of tyrosinase in ...201121410768
"high in omega-3 fatty acids" bologna-type sausages stabilized with an aqueous-ethanol extract of melissa officinalis.a new formulation of bologna-type sausage enriched in ?-3 polyunsaturated fatty acids (pufa) (8.75% linseed oil) was developed, using a lyophilized aqueous-ethanolic extract of melissa officinalis. a comparison with the effectiveness of butylhydroxy anisole (bha) synthetic antioxidant to decrease the oxidation of pufas was performed. the formulation increased the ?-3 pufas content, especially a-linolenic acid, decreasing significantly the ?-6/?-3 ratio from 17.3 to 1.9, and also the atherogenic ...201121439735
the anti-angiogenic herbal extracts ob-x from morus alba, melissa officinalis, and artemisia capillaris suppresses adipogenesis in 3t3-l1 adipocytes.growing adipose tissue is thought to require adipogenesis, angiogenesis, and extracellular matrix (ecm) remodeling. close examination of developing adipose tissue microvasculature reveals that angiogenesis often precedes adipogenesis. since our previous study demonstrated that ob-x, the anti-angiogenic herbal composition composed of melissa officinalis l. (labiatae), morus alba l. (moraceae), and artemisia capillaris thunb. (compositae), reduced adipose tissue mass in obese mice, we hypothesized ...201121449830
inhibition of hiv-1 infection by aqueous extracts of prunella vulgaris l.abstract:201121513560
the anti-angiogenic herbal composition ob-x from morus alba, melissa officinalis, and artemisia capillaris regulates obesity in genetically obese ob/ob mice.context: the growth and development of adipose tissue leading to obesity is suggested to depend on angiogenesis. our previous study showed that melissa officinalis l. (labiatae), morus alba l. (moraceae), and artemisia capillaris thunb. (compositae) are involved in the regulation of angiogenesis. we hypothesized that ob-x, a mixture of three herbs, m. alba, m. officinalis, and a. capillaris, can regulate obesity. objective: to investigate the inhibitory effect of ob-x on obesity in genetically o ...201121554004
antibiofilm activity of selected plant essential oils and their major components.the aim of the study was to examine the antibiofilm activity of selected essential oils (eo): lavandula angustifblia (leo), melaleuca alternifolia (tto), melissa officinalis (meo) and some of their major constituents: linalool, linalyl acetate, alpha-terpineol, terpinen-4-ol. biofilms were formed by staphylococcus aureus atcc 29213 and escherichia coli nctc 8196 on the surface of medical biomaterials (urinary catheter, infusion tube and surgical mesh). ttc reduction assay was used for the evalua ...201121630572
radical scavenging, antibacterial, and antiproliferative activities of melissa officinalis l. extracts.the aromatic herb melissa officinalis l. can be used as an easily accessible source of natural antioxidants and as a possible food supplement and as a phytochemical. radical scavenging, antibacterial, and antiproliferative activities of petroleum ether, chloroform, ethyl acetate, n-butanol, and water extracts of m. officinalis l. extracts were investigated. the results of antioxidative activity, obtained by electron spin resonance spectroscopy, confirmed that investigated extracts suppressed the ...200818361749
effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (gaba) canada, the use of botanical natural health products (nhps) for anxiety disorders is on the rise, and a critical evaluation of their safety and efficacy is required. the purpose of this study was to determine whether commercially available botanicals directly affect the primary brain enzymes responsible for gamma-aminobutyric acid (gaba) metabolism. anxiolytic plants may interact with either glutamic acid decarboxylase (gad) or gaba transaminase (gaba-t) and ultimately influence brain gaba le ...200718066140
antioxidant capacity and total phenolic contents of oregano (origanum vulgare), lavender (lavandula angustifolia) and lemon balm (melissa officinalis) from romania.the study reported here presents a comparative screening of three medicinal plants including oregano (origanum vulgare l.), lavender (lavandula angustifolia) and lemon balm (melissa officinalis) having the same geographical origin, the southeast region of romania, and growing in the same natural conditions. the contents of total phenolics and total flavonoids for the extracts of these were determined. furthermore, the total antioxidant capacity was also evaluated. it was found that origanum vulg ...201121707233
Evaluation of the genotoxic and antigenotoxic potential of Melissa officinalis in mice.Melissa officinalis (L.) (Lamiaceae), a plant known as the lemon balm, is native to the east Mediterranean region and west Asia. Also found in tropical countries, such as Brazil, where it is popularly known as "erva-cidreira" or "melissa", it is widely used in aqueous- or alcoholic-extract form in the treatment of various disorders. The aim was to investigate in vivo its antigenotoxicity and antimutagenicity, as well as its genotoxic/mutagenic potential through comet and micronucleus assaying. C ...201121734832
Protective effect of Melissa officinalis aqueous extract against Mn-induced oxidative stress in chronically exposed mice.Manganese (Mn) is an essential element for biological systems; however occupational exposure to high levels of this metal may lead to neurodegenerative disorders, resembling Parkinson's disease (PD). While its mechanisms of neurotoxicity have yet to be fully understood, oxidative stress plays a critical role. Thus, the main goal of this study was to investigate the efficacy of aqueous extract of Melissa officinalis in attenuating Mn-induced brain oxidative stress in mice. Sixteen male mice were ...201222020131
the psychopharmacology of european herbs with cognition-enhancing properties.extensive research suggests that a number of plant-derived chemicals and traditional oriental herbal remedies possess cognition-enhancing properties. widely used current treatments for dementia include extracts of ginkgo biloba and several alkaloidal, and therefore toxic, plant-derived cholinergic agents. several non-toxic, european herbal species have pan-cultural traditions as treatments for cognitive deficits, including those associated with ageing. to date they have not received research int ...200617168769
the in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from portugal.essential oil, ethanolic extract and decoction of 10 plant species from interior portugal were analyzed for their activity towards acetylcholinesterase (ache) enzyme and their antioxidant activity. of these, melissa officinalis, paronychia argentea, sanguisorba minor, hypericum undulatum and malva silvestris are used in herbal medicine, laurus nobilis and mentha suaveolens as condiments, and salvia officinalis, lavandula angustifolia and lavandula pedunculata also as aromatics. melissa officinal ...200616737790
lippia alba, melissa officinalis and cymbopogon citratus: effects of the aqueous extracts on the isolated hearts of rats.1. this research was developed to evaluate the actions of the aqueous extracts of leaves of lippia alba, melissa officinalis and cymbopogon citratus upon contractile force (cf) and cardiac rate (cr). 2. for the experiments in isolated heart, 21 male adult rats were used. the hearts were perfused according to langendorff's method. the records of cf and cr were obtained in control and after application of the extracts. the extracts were utilized in doses: 0.038, 0.38, 3.8 and 38 mg. results obtain ...200415458767
Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances.Botanicals are an alternative option to prescription drugs for the alleviation of symptoms due to anxiety disorders and insomnia. Melissa officinalis L. has been shown as an anti-stress and anxiolytic agent. We previously reported moderate stress improvement in mice in which Cyracos(®), a standardized Melissa officinalis L. extract, was administrated. Cyracos(®) contains phytochemicals that inhibit gamma-aminobutyric acid catabolism. This was a prospective, open-label, 15-day study to evaluate t ...201122207903
antioxidant and antibacterial activity of the beverage obtained by fermentation of sweetened lemon balm
(melissa officinalis l.) tea with symbiotic consortium 
of bacteria and yeasts.kombucha is a fermented tea beverage which is traditionally prepared by fermenting sweetened black or green tea (camellia sinensis l.) with symbiotic consortium of bacteria and yeasts (scoby). in this study, lemon balm (melissa officinalis l.) was used as the only nitrogen source for kombucha fermentation. during the seven-day fermentation process, ph value, titratable acidity (ta), total phenolic content, phenolic compounds, and antioxidant activity against hydroxyl (˙oh) and 1,1-diphenyl-2-pic ...201427904315
melissa officinalis l. essential oil: antitumoral and antioxidant activities.melissa officinalis l (lemon balm) is a traditional herbal medicine used widely as a mild sedative, spasmolytic and antibacterial agent. this paper focuses on the analysis of the chemical composition and the biological activities of m. officinalis essential oil obtained under controlled harvesting and drying conditions. an in-vitro cytotoxicity assay using mtt indicated that this oil was very effective against a series of human cancer cell lines (a549, mcf-7, caco-2, hl-60, k562) and a mouse cel ...200415142347
ftir spectroscopic evaluation of changes in the cellular biochemical composition of the phytopathogenic fungus alternaria alternata induced by extracts of some greek medicinal and aromatic this study, the biological activity of aquatic extracts of selected greek medicinal and aromatic plants to the phytopathogenic fungus alternaria alternata was investigated. lamiaceae species (hyssopus officinalis l., melissa officinalis l., origanum dictamnus l., origanum vulgare l. and salvia officinalis l.) were found to enhance significantly the mycelium growth whereas crocus sativus appears to inhibit it slightly. m. officinalis and s. officinalis caused the highest stimulation in myceliu ...201424657421
drug target identification and elucidation of natural inhibitors for bordetella petrii: an in silico study.environmental microbes like bordetella petrii has been established as a causative agent for various infectious diseases in human. again, development of drug resistance in b. petrii challenged to combat against the infection. identification of potential drug target and proposing a novel lead compound against the pathogen has a great aid and value. in this study, bioinformatics tools and technology have been applied to suggest a potential drug target by screening the proteome information of b. pet ...201628154518
chemical composition and antimicrobial activity of the essential oil from leaves of algerian melissa officinalis l.the essential oil obtained from leaves of melissa officinalis l. (family of lamiaceae) growing in algeria, was investigated for its chemical composition and in vitro antimicrobial activity. the chemical composition was determined by hydrodistillation and analyzed by gc/ms and gc-fid. sixty-three compounds were identified in the essential oil, representing 94.10 % of the total oil and the yields were 0.34 %. the major component was geranial (44.20 %). other predominant components were neral (30.2 ...201426417300
antiviral activity of the oseltamivir and melissa officinalis l. essential oil against avian influenza a virus (h9n2).lemon balm derivatives are going to acquire a novelty as natural and potent remedy for treatment of viral infections since the influenza viruses are developing resistance to the current antivirals widely. oseltamivir, melissa officinalis essential oil (moeo) and their synergistic efficacy against avian influenza virus (aiv) subtype h9n2 were evaluated in vitro in mdck cells at different time exposure by using tcid50, ha, real time pcr and hi assay. the results showed that moeo could inhibit repl ...201627366768
attachment and penetration of acyclovir-resistant herpes simplex virus are inhibited by melissa officinalis extract.medicinal plants are increasingly of interest as novel source of drugs for antiherpetic agents, because herpes simplex virus (hsv) might develop resistance to commonly used antiviral drugs. an aqueous extract of melissa officinalis and the phenolic compounds caffeic acid, p-coumaric acid and rosmarinic acid were examined for their antiviral activity against herpes simplex virus type 1 (hsv-1) acyclovir-sensitive and clinical isolates of acyclovir-resistant strains in vitro. when drugs were added ...201424817544
melissa officinalis extract inhibits attachment of herpes simplex virus in vitro.extracts and essential oils of medicinal plants are increasingly of interest as novel drugs for antiherpetic agents, since the herpes simplex virus (hsv) might develop resistance to commonly used antiviral drugs.201222377592
pp-12 efficacy of a standardized extract of matricariae chamomilla l., melissa officinalis l. and tyndallized lactobacillus acidophilus (h122) compared with lactobacillus reuteri (dsm 17938) and with simethicone for the treatment of infantile colic.infant colic is a prevalent physiological event of healthy children under 3 months of age, which can disrupt the child's home environment. despite its benign natural history, sometimes it requires a therapeutic approach. there is limited evidence supporting the use of complementary and alternative treatments. the aim of this study was to investigate the effectiveness of a mixture of standardized extract of matricariae chamomilla l., melissa officinalis l. and tyndallized lactobacillus acidophilu ...201526439577
modulation of mood and cognitive performance following acute administration of single doses of melissa officinalis (lemon balm) with human cns nicotinic and muscarinic receptor-binding properties.melissa officinalis (lemon balm) is a herbal medicine that has traditionally been attributed with memory-enhancing properties, but which is currently more widely used as a mild sedative and sleep aid. in a previous study it was demonstrated that a commercial melissa extract led to dose-specific increases in calmness, and dose-dependent decrements in timed memory task performance. however, the extract utilized in that study did not exhibit in vitro cholinergic receptor-binding properties. the cur ...200312888775
hplc-dad phenolic profile, cytotoxic and anti-kinetoplastidae activity of melissa officinalis.context melissa officinalis subsp. inodora bornm. (lamiaceae) has been used since ancient times in folk medicine against various diseases, but it has not been investigated against protozoa. objective to evaluate the activities of m. officinalis against leishmania braziliensis, leishmania infantum and trypanosoma cruzi as well as its cytotoxicity in fibroblast cell line. materials and methods the fresh leaves were chopped into 1 cm(2) pieces, washed and macerated with 99.9% of ethanol for 72 h at ...201626864563
phytochemistry and nematicidal activity of the essential oils from 8 greek lamiaceae aromatic plants and 13 terpene components.eight essential oils (eos) as well as 13 single terpenes were studied for their nematicidal activity against meloidogyne incognita , for three immersion periods (24, 48, and 96 h). the eos were isolated from eight greek lamiaceae species: melissa officinalis , sideritis clandestina , origanum dictamnus , ocimum basilicum , mentha pulegium , origanum vulgare , vitex agnus castus , and salvia officinalis . the eos nematicidal activity was correlated to their chemical composition as well as to the ...201020527965
essential oil composition and antifungal activity of melissa officinalis originating from north-est morocco, against postharvest phytopathogenic fungi in investigate biological control methods against post-harvest phytopathogenic fungi in apples, tests on the antifungal activity of essential oil of melissa officinalis were carried out. the essential oil, obtained by hydrodistillation, was analyzed by gas chromatography coupled with mass spectrometry (gc-ms). analysis of the essential oil was able to detect 88.7% of the components. the main components are p-mentha-1,2,3-triol (13.1%), p-menth-3-en-8-ol (8.8%), pulegone (8.8%), piperitynone oxid ...201728389346
melissa officinalis l. decoctions as functional beverages: a bioactive approach and chemical characterization.lemon balm (melissa officinalis l.) is a member of the lamiaceae family with a long story of human consumption. it has been consumed for decades, directly in food and as a decoction or an infusion for its medicinal purposes. in this manuscript, a detailed chemical characterization of the decoction of this plant is described, encompassing antimicrobial, antioxidant and antitumor activities. rosmarinic acid and lithospermic acid a were the most abundant phenolic compounds. quinic acid, fructose, g ...201526075899
an evaluation of the inhibitory effects against rotavirus infection of edible plant extracts.rotaviruses are the single most important cause of severe diarrhea in young children worldwide. the developments of specific, potent and accessible antiviral treatments that restrain rotavirus infection remain important to control rotavirus disease.201222834653
modulation of mood and cognitive performance following acute administration of melissa officinalis (lemon balm).melissa officinalis (lemon balm) is a traditional herbal medicine, which enjoys contemporary usage as a mild sedative, spasmolytic and antibacterial agent. it has been suggested, in light of in vitro cholinergic binding properties, that melissa extracts may effectively ameliorate the cognitive deficits associated with alzheimer's disease. to date, no study has investigated the effects on cognition and mood of administration of melissa to healthy humans. the present randomised, placebo-controlled ...200212062586
antiulcerogenic effect of some gastrointestinally acting plant extracts and their combination.extracts from the plants iberis amara, melissa officinalis, matricaria recutita, carum carvi, mentha x piperita, glycyrrhiza glabra, angelica archangelica, silybum marianum and chelidonium majus, singly and combined in the form of a commercial preparation, stw 5 (iberogast) and a modified formulation, stw 5-ii, lacking the last 3 constituents, were tested for their potential anti-ulcerogenic activity against indometacin induced gastric ulcers of the rat as well as for their antisecretory and cyt ...200111505785
adverse effects of herbal medicines: an overview of systematic reviews.this overview of systematic reviews (srs) aims to evaluate critically the evidence regarding the adverse effects of herbal medicines (hms). five electronic databases were searched to identify all relevant srs, with 50 srs of 50 different hms meeting our inclusion criteria. most had only minor weaknesses in methods. serious adverse effects were noted only for four hms: herbae pulvis standardisatus, larrea tridentate, piper methysticum and cassia senna. the most severe adverse effects were liver o ...201323472485
cns acetylcholine receptor activity in european medicinal plants traditionally used to improve failing memory.certain lamiaceous and asteraceous plants have long histories of use as restoratives of lost or declining cognitive functions in western european systems of traditional medicine. investigations were carried out to evaluate human cns cholinergic receptor binding activity in extracts of those european medicinal plants reputed to enhance or restore mental functions including memory. ethanolic extracts were prepared from accessions of these plants and a number of other species related by genus. amon ...200010687867
anti-hiv-1 activity of herbs in labiatae.the anti-hiv-1 activity of aromatic herbs in labiatae was evaluated in vitro. forty five extract from among 51 samples obtained from 46 herb species showed significant inhibitory effects against hiv-1 induced cytopathogenicity in mt-4 cells. in particular, the aqueous extracts of melissa officinalis, a family of mentha x piperita "grapefruit mint," mentha x piperita var. crispa, ocimum basilicum cv "cinnamon," perilla frutescens var. crispa f. viridis, prunella vulgaris subsp. asiatica and satur ...19989743251
exploring biodiversity in the bacterial community of the mediterranean phyllosphere and its relationship with airborne bacteria.we studied the structure and diversity of the phyllosphere bacterial community of a mediterranean ecosystem, in summer, the most stressful season in this environment. to this aim, we selected nine dominant perennial species, namely arbutus unedo, cistus incanus, lavandula stoechas, myrtus communis, phillyrea latifolia, pistacia lentiscus, quercus coccifera (woody), calamintha nepeta, and melissa officinalis (herbaceous). we also examined the extent to which airborne bacteria resemble the epiphyt ...201222544345
a review study on the effect of iranian herbal medicines on opioid withdrawal syndrome.addiction is a chronic and recurring disease that recurrence phenomenon is the most important challenge in treatment of this disease. recent experiences have shown that synthetic drugs have undesirable side effects. recent studies on medicinal plants have shown that they might be effective in treatment of different stages of addiction with lower side effects and costs. the aim of this study was to review the effects of medicinal plants in the treatment of morphine addiction in experimental anima ...201525818661
screening of medicinal plants for induction of somatic segregation activity in aspergillus nidulans.knowledge about mutagenic properties of plants commonly used in traditional medicine is limited. a screening for genotoxic activity was carried out in aqueous or alcoholic extracts prepared from 13 medicinal plants widely used as folk medicine in cuba: lepidium virginicum l. (brassicaceae): plantago major l. and plantago lanceolata l. (plantaginaceae); ortosiphon aristatus blume, mentha x piperita l., melissa officinalis l. and plectranthus amboinicus (lour.) spreng. (lamiaceae); cymbopogon citr ...19968771452
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