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antifungal activity of the essential oil of agastache rugosa kuntze and its synergism with ketoconazole.to evaluate the fungitoxic activity of the essential oil of agastache rugosa alone and to determine its combination effect with ketoconazole against blastoschizomyces capitatus.200312535132
effects and possible mechanisms of action of acacetin on the behavior and eye morphology of drosophila models of alzheimer's disease.the human β-amyloid (aβ) cleaving enzyme (bace-1) is a target for alzheimer's disease (ad) treatments. this study was conducted to determine if acacetin extracted from the whole agastache rugosa plant had anti-bace-1 and behavioral activities in drosophila melanogaster ad models and to determine acacetin's mechanism of action. acacetin (100, 300, and 500 μm) rescued amyloid precursor protein (app)/bace1-expressing flies and kept them from developing both eye morphology (dark deposits, ommatidial ...201526530776
anti‑inflammatory and antioxidant activity of the traditional herbal formula gwakhyangjeonggi‑san via enhancement of heme oxygenase‑1 expression in raw264.7 macrophages.gwakhyangjeonggi‑san (ghjgs) is a mixture of herbal plants, including agastache rugosa, perilla frutescens, angelica dahurica, areca catechu, poria cocos, magnolia officinalis, atractylodes macrocephala, citrus reticulata, pinellia ternata, platycodon grandiflorum, glycyrrhiza uralensis, ziziphus jujuba and zingiber officinale. ghjgs has been used for treating diarrhea‑predominant irritable bowel syndrome in traditional korean medicine. in the present study, the anti‑inflammatory and antioxidant ...201627052497
the polyphenolic profiles and antioxidant effects of agastache rugosa kuntze (banga) flower, leaf, stem and root.agastache rugosa kuntze (korean mint) is used as a spice and in folk medicine in east asia. the present study identified a total of 18 polyphenols from the flower, leaf, stem and roots of this plant using high-performance liquid chromatography-tandem mass spectrometry. fourteen of these compounds had not previously been identified in these plant tissues. each polyphenol was validated in comparison with external calibration curves constructed using structurally related compounds, with determinati ...201626094749
antimicrobial, antibiofilm and antitumor activities of essential oil of agastache rugosa from xinjiang, china.in the study, we evaluated chemical composition and antimicrobial, antibiofilm, and antitumor activities of essential oils from dried leaf essential oil of leaf and flower of agastache rugosa for the first time. essential oil of leaf and flower was evaluated with gc and gc-ms methods, and the essential oil of flower revealed the presence of 21 components, whose major compounds were pulegone (34.1%), estragole (29.5%), and p-menthan-3-one (19.2%). 26 components from essential oil of leaf were ide ...201627298587
attenuating properties of agastache rugosa leaf extract against ultraviolet-b-induced photoaging via up-regulating glutathione and superoxide dismutase in a human keratinocyte cell line.agastache rugosa kuntze, known as a korean mint, is an herbal medicine that has been used for the treatment of diverse kinds of symptoms in traditional medicine. this work was undertaken to assess the protective properties of a. rugosa leaves against uv-b-induced photoaging in hacat keratinocytes. they were evaluated via analyzing reactive oxygen species (ros), promatrix metalloproteinase-2 (prommp-2) and -9 (prommp-9), total glutathione (gsh), total superoxide dismutase (sod), cellular viabilit ...201627579986
protective mechanisms of acacetin against d-galactosamine and lipopolysaccharide-induced fulminant hepatic failure in mice.this study examined the hepatoprotective effects of acacetin (1), a flavonoid isolated from agastache rugosa, against d-galactosamine (galn) and lipopolysaccharide (lps)-induced fulminant hepatic failure. mice were given an intraperitoneal injection of 1 (25, 50, and 100 mg/kg), or the vehicle alone (5% dimethyl sulfoxide-saline), 1 h before galn (800 mg/kg)/lps (40 μg/kg) treatment and sacrificed at 6 h after galn/lps injection. galn/lps markedly increased mortality and serum aminotransferase a ...201425382719
demethyleugenol β-glucopyranoside isolated from agastache rugosa decreases melanin synthesis via down-regulation of mitf and sox9.agastache rugosa (fisch. & c. a. mey.) kuntze has been well-known for its antioxidative properties. this study investigated the anti-melanogenesis effect of demethyleugenol β-d-glucopyranoside (1) from a. rugosa by studying molecular regulation of melanogenesis in melan-a mouse melanocytes and normal human epidermal melanocytes (nhems) and in in vivo models. the sry (sex-determining region on the y chromosome)-related high-mobility group (hmg) box 9 (sox9), one of the critical factors that affec ...201627673705
accumulation of tilianin and rosmarinic acid and expression of phenylpropanoid biosynthetic genes in agastache rugosa.korean mint (agastache rugosa), a perennial, medicinal plant of the labiatae family, has many useful constituents, including monoterpenes and phenylpropanoids. among these, tilianin and rosmarinic acid, 2 well-known natural products, have many pharmacologically useful properties. chalcone synthase (chs) and chalcone isomerase (chi) catalyze the first and second committed steps in the phenylpropanoid pathway of plants, leading to the production of tilianin. in this study, cdnas encoding chs (arch ...201222630830
anti-adipogenic effects of ethanol extracts prepared from selected medicinal herbs in 3t3-l1 cells.obesity is a major risk factor for various metabolic diseases such as cardiovascular disease, hypertension, and type 2 diabetes mellitus. in this study, we prepared ethanol extracts from agastache rugosa (are), chrysanthemum zawadskii (cze), mentha arvensis (mae), perilla frutescens (pfe), leonurus sibiricus (lse), gardenia jasminoides (gje), and lycopus coreanus (lce). the anti-oxidant and anti-adipogenic effects were evaluated. the ic50 values for ascorbic acid and lce against 2,2-diphenyl-1-p ...201627752499
protein kinase g-dependent heme oxygenase-1 induction by agastache rugosa leaf extract protects raw264.7 cells from hydrogen peroxide-induced injury.it has been proposed that the inducible isoform of heme oxygenase (ho) protects cells against oxidant-mediated injury. although components of agastache rugosa showed antioxidant effect, it is unclear this effect is related with ho-1 activity. thus, we investigated the effects of agastache rugosa leaf extract (ale) on ho-1 protein expression and enzyme activity, and its protective effect against h(2)o(2)-induced oxidative damage was also investigated using raw264.7 macrophage cells. results showe ...200616185832
analysis of tilianin and acacetin in agastache rugosa by high-performance liquid chromatography with ionic liquids-ultrasound based extraction.ionic liquid 1-butyl-3-methylimidazolium bromide-methanol-based ultrasonic-assisted extraction (iluae) was used to extract tilianin and acacetin from the aerial parts of agastache rugose (a. rugose), and simultaneously determined by reversed phase high performance liquid chromatographic (rp-hplc) method with ultraviolet detection (rp-hplc-uv). an inertsustain rp-c18 column was used with the mobile phase consisting of methanol and 0.2% acetic acid as gradient elution at the detection wavelength o ...201627994640
chemical constituents and coagulation activity of agastache rugosa.in the chinese traditional medicine, plant of agastache rugosa (fisch. & c.a. mey.) kuntze (a. rugosa) has been used to treat nausea, vomiting and dispel damp. however, currently, few reports about the chemical constituents, especially the non-volatile components of a. rugosa are available.201728166786
[dna sequencing and molecular identification of patchouli and its substitute wrinkled gianthyssop].to analyze sequences of the nuclear ribosomal rna small subunit (18s rrna) gene and the chloroplast matk gene of crude drug patchouli (pogostemon cablin) in order to provide molecular evidence for identification of patchouli drug.200212567903
[effect of space flight on ultrastructure of chloroplast in agastache rugosa].to substantiate the effects of space condition on medicinal plants, the seeds of agastache rugosa were set up in retrievable satellites.199912567497
molecular cloning, functional expression and characterization of d-limonene synthase from agastache rugosa.we cloned the gene of d-limonene synthase (arlms) from agastache rugosa (labiatae). the function of arlms was elucidated by the preparation of recombinant protein and subsequent enzyme assay. arlms consisted of 2077 nucleotides including 1839 bp of coding sequence that encodes a protein of 613 amino acids. this protein has a 60 kda molecular weight, which is identical to that of d-limonene synthase from schizonepeta tenuifolia (labiatae). the deduced amino acid sequence of arlms shows high homol ...200212033511
β-caryophyllene alleviates d-galactosamine and lipopolysaccharide-induced hepatic injury through suppression of the tlr4 and rage signaling pathways.agastache rugosa (a. rugosa, labiatae), a perennial herb spread throughout korean fields, is widely consumed as a wild edible vegetable and is used in folk medicine. this study examined the hepatoprotective mechanisms of β-caryophyllene (bcp), a major bicyclic sesquiterpene of a. rugosa, against d-galactosamine (galn) and lipopolysaccharide (lps)-induced hepatic failure. mice were given an intraperitoneal injection of bcp (50, 100 and 200 mg/kg) 1 h before galn (800 mg/kg)/lps (40 μg/kg) injecti ...201526254779
five htrpa1 agonists found in indigenous korean mint, agastache rugosa.transient receptor potential ankyrin1 (trpa1) and transient receptor potential vanilloid 1 (trpv1) are members of the trp superfamily of structurally related, nonselective cation channels and mediators of several signaling pathways. previously, we identified methyl syringate as an htrpa1 agonist with efficacy against gastric emptying. the aim of this study was to find htrpa1 and/or htrpv1 activators in agastache rugosa (fisch. et meyer) o. kuntze (a.rugosa), commonly known as korean mint to impr ...201525978436
[miscellaneous contributions to the essential oils of the plants from various territories. 33. essential oil of agastache rugosa o. kuntze. 6 (author's transl)]. 19734798804
[miscellaneous contributions to the essential oils of the plants from various territories. xxix. essential oil of agastache rugosa o. kuntze. (5). sesquiterpene hydrocarbons in the oil]. 19724676235
analysis of the volatile organic compounds from leaves, flower spikes, and nectar of australian grown agastache rugosa.the foraging choices of honey bees are influenced by many factors, such as floral aroma. the composition of volatile compounds influences the bioactivity of the aromatic plants and honey produced from them. in this study, agastache rugosa was evaluated as part of a project to select the most promising medicinal plant species for production of bioactive honey.201425510964
metabolomics analysis and biosynthesis of rosmarinic acid in agastache rugosa kuntze treated with methyl jasmonate.this study investigated the effect of methyl jasmonate (meja) on metabolic profiles and rosmarinic acid (ra) biosynthesis in cell cultures of agastache rugosa kuntze. transcript levels of phenylpropanoid biosynthetic genes, i.e., arpal, ar4cl, and arc4h, maximally increased 4.5-fold, 3.4-fold, and 3.5-fold, respectively, compared with the untreated controls, and the culture contained relatively high amounts of ra after exposure of cells to 50 µm meja. ra levels were 2.1-, 4.7-, and 3.9-fold high ...201323724034
[analysis of essential oil in herbal pair artemisia annua-agastache rugosa by gc-ms and chemometric resolution method].gas chromatograph-mass spectrometry, chemometric resolution method (crm) and overall volume integration method were used to analyze the essential components of herbal pair artemisia annua-agastache rugosa (aa-ar) and compare it with that of single herbs aa and ar. the results showed that the components of volatile oil of herbal pair (aa-ar) were different from that of single herb drug in quality and quantity. 70, 69, and 48 essential components in essential oil of herbal pair (aa-ar), aa and ar ...200921355326
essential oil compounds from agastache rugosa as antifungal agents against trichophyton species.the antifungal activities of the essential oil from agastache rugosa and its main component, estragole, combined with ketoconazole, one of the azole antibiotics commonly used to treat infections caused by trichophyton species, were evaluated in this study. the combined effects were measured by the checkerboard microtiter and the disk diffusion tests, against t. erinacei, t. mentagrophytes, t. rubrum, t. schoenleinii and t. soudanense. susceptibility of the five trichophyton species to the oil al ...200415089034
[chemical composition of essential oil in stems, leaves and flowers of agastache rugosa].the chemical components and their relative contents of essential oil in different parts (stems, leaves and flowers) of agastache rugosa have been analyzed by gc-ms technique, and 32 kinds of chemical structures in these three kinds of oils have been identified. among which, it included 24 kinds in leaf-oil, 27 in stem-oil and 22 in flower-oil. the principal components in all these three kinds of oils were methylchavicol (60.01-88.43%), and other important components were d-limonene, caryophyllen ...200012575134
yeast extract and silver nitrate induce the expression of phenylpropanoid biosynthetic genes and induce the accumulation of rosmarinic acid in agastache rugosa cell culture.the present study aimed to investigate the role of yeast extract and silver nitrate on the enhancement of phenylpropanoid pathway genes and accumulation of rosmarinic acid in agastache rugosa cell cultures. the treatment of cell cultures with yeast extract (500 mg/l) and silver nitrate (30 mg/l) for varying times enhanced the expression of genes in the phenylpropanoid pathway and the production of rosmarinic acid. the results indicated that the expression of ras and hppr was proportional to the ...201627043507
chemical composition and nematicidal activity of essential oil of agastache rugosa against meloidogyne incognita.the aim of this research was to determine the chemical composition and nematicidal activity of essential oil of agastache rugosa flowering aerial parts against the root knot nematode, meloidogyne incognita, and to isolate and identify any nematicidal constituents from the essential oil. the essential oil of a. rugosa aerial parts was obtained by hydrodistillation and analyzed by gc-fid and gc-ms. a total of 37 components of the essential oil were identified, with the principal compounds being me ...201323571530
effect of inhibition on tyrosinase and melanogenesis of agastache rugosa kuntze by lactic acid bacteria fermentation.this work presents the first report that a. rugosa could have tyrosinase and melanogenesis inhibition and that its activities also be improved by fermentation with lactobacillus rhamnosus and lactobacillus paracasei. it was found that the tyrosinase and melanogenesis inhibition was correlated with antioxidant activity of acacetin, the major biologically active substances in a. rugosa.201627531590
microscopic identification and in vitro activity of agastache rugosa (fisch. et mey) from xinjiang, china.agastache rugosa is well-known as a common traditional chinese medicine, which have relieving summer-heat, analgesic and antipyretic effects, have long been used as folkloristic remedy in the treatment of several infectious diseases, anti-inflammatory, and for its antibacterial properties. considering the lack of available data on the morphology, anatomy and in vitro activity of a. rugosa, the goal of the present study was to carry out the microscopic identification of its aerial parts and in vi ...201728173792
active components of common traditional chinese medicine decoctions have antioxidant functions.many traditional chinese medicine (tcm) decoctions are proven to have multiple functions in animal production. they are seldom recognized by the international scientific community, as the mechanisms of action are not clearly elucidated. according to tcm theory, cortex phellodendron (cop), rhizoma atractylodes (ra), agastache rugosa (ar) and gypsum fibrosum (gf) can be used to formulate a medicinal compound that prevents or cures animal disease caused by heat stress. the aim of this research was ...201121571894
gc-ms fingerprint of pogostemon cablin in china.pogostemon cablin, originating in malaysia and india, is cultivated in southern china including guangdong and hainan province, which was called guanghuoxiang to differentiate it from the huoxiang of the north, the species agastache rugosa, that it resembles. essential oil of p. cablin mainly contributes to the pharmacological activities and the therapeutic properties of the essential oils are directly correlated with their qualitative and quantitative composition. for controlling the quality, st ...200616242880
[effects of space flight on medicinal plant agastache rugosa (fisch. et mey.) o. ktze].to substantiate the effect of space conditions on medicinal plants.199911542774
inhibition of cytokine-induced vascular cell adhesion molecule-1 expression; possible mechanism for anti-atherogenic effect of agastache rugosa.adhesion molecules such as vascular cell adhesion molecule-1 (vcam-1) play an important role during the early stages of atherogenesis. agastache rugosa has an anti-atherogenic effect in low density lipoprotein receptor -/- mice. moreover, a. rugosa reduced macrophage infiltration and vcam-1 expression has been localized in aortic endothelium that overlies early foam cell lesions. this study ascertained that tilianin (100 microm), a major component of a. rugosa, inhibits the tumor necrotic factor ...200111334881
screening for antimycotic properties of 56 traditional chinese drugs.in the present study we screened extracts of 56 widely used dried chinese medical plants or their parts (tcd) for their antimycotic properties against pathological phyla of aspergillus fumigatus, candida albicans, geotrichum candidum and rhodotorula rubra. the highest activity against aspergillus fumigatus was shown by carthamus tinctorius l. (flos) and rheum palmatum l. (radix et rhizoma) and against candida albicans, scutellaria baicalensis georgi (radix) had the highest activity. the highest ...200010815018
hiv integrase inhibitory activity of agastache rugosa.we have been screening anti-hiv integrase compounds from korean medicinal plants by using an in vitro assay system which is mainly composed of recombinant human immunodeficiency virus type 1 integrase and radiolabeled oligonucleotides. from the above screening, the aqueous methanolic extract of the roots of agastache rugosa exhibited a significant activity. bioactivity-guided chromatographic fractionation of the methanolic extract resulted in the isolation of rosmarinic acid. the structure of th ...199910549582
inhibitory constituents against hiv-1 protease from agastache rugosa.two diterpenoid compounds, agastanol (1) and agastaquinone (2), were isolated from the roots of agastache rugosa (labiatae). compound 1 and 2 showed significant inhibitory effects against human immunodeficiency virus type 1 (hiv-1) protease activity with ic50 values of 360 and 87 microm, respectively.199910071964
agastaquinone, a new cytotoxic diterpenoid quinone from agastache rugosa.a new diterpenoid quinone, agastaquinone [1], was isolated from the roots of agastache rugosa. an oxime derivative [2] of agastaquinone was prepared with hydroxylamine hydrochloride. the structure of agastaquinone [1] was established as 7-hydroxy-12-methoxy-20-norabieta-1,5(10),6,8,12-pentaene-3,11,14- trione by spectroscopic techniques. compounds 1 and 2 showed nonspecific cytotoxic activities against several human cancer cell lines in vitro (a549, sk-ov-3, sk-mel-2, xf498, and hct15).19958594148
[studies on the chemical constituents from roots of agastache rugosa].eleven compounds were isolated from roots of agastache rugosa and eight of them were identified as maslinic acid (i), oleanolic acid (ii), 3-o-acetyl oleanolic aldehyde (iii), acacetin (iv), tilianin (v), agastachoside (vi), daucosterol (vii) and beta-sitosterol (viii). compound ix is a new diterpenoid and its structure was proposed to be 19(4----3)abeo-11,14-dihydroxy-12-methoxy-abieta-8,11,13,15- tetraen-7-one based on spectral data, named dehydroagastol. the studies on x and xi are in progres ...19911823989
agastinol and agastenol, novel lignans from agastache rugosa and their evaluation in an apoptosis inhibition assay.investigation of the whole plant of agastache rugosa resulted in the isolation of two new lignan compounds. their structures were elucidated as (8s,7'r,8's)-4-hydroxybenzoic acid 4-(4-hydroxy-3-methoxybenzyl)-2-(4-hydroxy-3-methoxyphenyl)tetrahydrofuran-3-ylmethyl ester (agastinol, 1) and (7'r,8's)-4-hydroxybenzoic acid 4-(hydroxy-3-methoxybenzylidene)-2-(4-hydroxy-3-methoxyphenyl)-tetrahydrofuran-3-ylmethyl ester (agastenol, 2). agastinol and agastenol inhibited etoposide-induced apoptosis in u ...200211908994
taguchi approach for anti-heat stress prescription compatibility in mice spleen lymphocytes in vitro.heat stress (hs) may induce immunosuppression as well as inhibit the proliferation of lymphocytes. this study evaluated the effects on immune function of our prescription on splenic lymphocytes under hs as well as its compatibility. the effects of four herbal extracts from agastache rugosa, atractylodes lancea, cortex phellodendri, and gypsum fibrosum on heat treated splenic lymphocytes were investigated and the compatibility of the prescription was also explored by using the taguchi method. thi ...201121811919
4-methoxycinnamaldehyde inhibited human respiratory syncytial virus in a human larynx carcinoma cell line.4-methoxycinnamaldehyde, an active constituent of agastache rugosa, was examined for its cytoprotective activity against rsv by xtt method in human larynx carcinoma cell line. 4-methoxycinnamaldehyde could effectively inhibit cytopathic effect of rsv (p<0.0001) with an estimated ic(50) of 0.055microg/ml and a selectivity index (si) of 898.2. 4-methoxycinnamaldehyde (0.03microg/ml) could inhibit viral entrance by interfering viral attachment (ic(50) of 0.06microg/ml; p<0.0001) and internalization ...200919303275
[professor ling changquan's experience in treating primary liver cancer: an analysis of herbal medication].on the basis of outpatients' medical records concerning primary liver cancer (plc), data of 552 patients (with 2020 effective prescriptions) from the outpatient department of changhai hospital treated by professor ling changquan were collected. the nature, flavor and meridian distribution of the herbs used in the prescriptions were summarized by frequency method, and the features of the herbs used according to syndrome differentiation were analyzed by logistic regression. the couple herbs used w ...200819063833
agastache rugosa leaf extract inhibits the inos expression in ros 17/2.8 cells activated with tnf-alpha and il-1beta.it has been suggested that nitric oxide (no) derived from inducible nitric oxide synthase (inos) may act as a mediator of cytokine-induced effects on bone turn-over. no is also recognized as an important factor in bone remodeling, i.e., participating in osteoblast apoptosis in an arthritic joint. the components of agastache rugosa are known to have many pharmacological activities. in the present study, we investigated the effects of agastache rugosa leaf extract (elar) on no production and the i ...200515832818
poliovirus infection and expression of the poliovirus protein 2b provoke the disassembly of the golgi complex, the organelle target for the antipoliovirus drug ro-090179.infection of vero cells with poliovirus results in complete disassembly of the golgi complex. milestones of the process of disassembly are the release to the cytosol of the beta-cop bound to golgi membranes, the disruption of the cis-golgi network into fragments scattered throughout the cytoplasm, and the disassembly of the stacked cisternae by a process mediated by long tubular structures. transient expression of the viral protein 2b in cos-7 cells also causes the disassembly of the golgi compl ...19979151862
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