| [development of the rudimentary prostates of ellobius lutescens (microtinae) in organ culture; effects of androgens (author's transl)]. | the structure of the rudimentary prostates of ellobius lutescens is maintained intact after 6 days of organotypic culture in the absence of male hormones. comparison with controls even shows a noticeable increase in the size of the epithelial cells. adding male hormones to the culture medium does not modify the morphology of adult prostates, while it induces a sharp stimulation of immature prostates. in accordance with our previous results, these experiments show that the prostates of ellobius l ... | 1976 | 955025 |
| aberrant chromosomal sex-determining mechanisms in mammals, with special reference to species with xy females. | both mouse and man have the common xx/xy sex chromosome mechanism. the x chromosome is of original size (5-6% of female haploid set) and the y is one of the smallest chromosomes of the complement. but there are species, belonging to a variety of orders, with composite sex chromosomes and multiple sex chromosome systems: xx/xy1y2 and x1x1x2x2/x1x2y. the original x or the y, respectively, have been translocated on to an autosome. the sex chromosomes of these species segregate regularly at meiosis; ... | 1988 | 2907806 |
| folic acid sensitive fragile sites are not limited to the human karyotype. demonstration of nonrandom gaps and breaks in the persian vole ellobius lutescens th. inducible by methotrexate, fluorodeoxyuridine, and aphidicolin. | at least four folic acid sensitive fragile sites have been detected in the karyotype of the persian vole ellobius lutescens th. (rodentia, microtinae). two such "hot spots" are located on chromosome 1 flanking the pericentric segment which is inverted in many individuals. the fragile site on 1p was observed on both homologues in one cell. our findings suggest that fragile sites are common properties of mammalian chromatin and might have played a role in karyotype evolution. | 1985 | 3159643 |
| the repeated dna sequences of microtinae. i. microtus agrestis, microtus pennsylvanicus and ellobius lutescens. | | 1973 | 4128137 |
| [hypogonadism in a rodent from iran: ellobius lutescens th: comparative action of injections of rat and ellobius pituitary on the genital system of immature rats]. | | 1967 | 4964417 |
| [hypogenitalism in a male iranian rodent, ellobius lutescens th.: action of serum gonadotropin treatments (pregnant mare serum: p.m.s.) on the genital system]. | | 1969 | 4981977 |
| aberrant sex chromosome mechanisms in mammals. evolutionary aspects. | there are a number of mammalian species with complicated or unknown mechanisms for sex determination. the literature is reviewed with special reference to the origin and evolution of the sex chromosome mechanisms in three species of monotremes and in the following species of rodents: the creeping vole (microtus oregoni), the mole vole (ellobius lutescens), the amami spinous country rat (tokudaia osimensis), the wood lemming (myopus schisticolor), the varying lemming (dicrostonyx torquatus), sout ... | 1983 | 6444170 |
| sex determination in ellobius lutescens: the story of an enigma. | the unusual karyotype of ellobius lutescens (2n = 17,x in males and females) has attracted permanent interest and prompted a series of hypotheses on sex determination in this species since its first description by matthey (1953). the developing knowledge about the sex chromosomes and sex determination as well as the availability of new cytogenetic and molecular genetic techniques prompted studies to test the compatibility between current hypotheses and new findings and rendered modifications of ... | 1998 | 9678361 |
| characterization of pisrt1/foxl2 in ellobius lutescens and exclusion as sex-determining genes. | the rodent ellobius lutescens is an exceptional mammal which determines male sex constitutively without the sry gene and, therefore, may serve as an animal model for human 46,xx female-to-male sex reversal. it was suggested that other factors of the network of sex-determining genes determine maleness in these animals. however, some sex-determining genes like sox9 and sf1 have already been excluded by segregation analysis as primary sex-determining factors in e. lutescens. in this work, we have c ... | 2005 | 15965789 |
| chromosomal evolution of arvicolinae (cricetidae, rodentia). ii. the genome homology of two mole voles (genus ellobius), the field vole and golden hamster revealed by comparative chromosome painting. | using cross-species chromosome painting, we have carried out a comprehensive comparison of the karyotypes of two ellobius species with unusual sex determination systems: the transcaucasian mole vole, ellobius lutescens (2n = 17, x in both sexes), and the northern mole vole, ellobius talpinus (2n = 54, xx in both sexes). both ellobius species have highly rearranged karyotypes. the chromosomal paints from the field vole (microtus agrestis) detected, in total, 34 and 32 homologous autosomal regions ... | 2007 | 17924201 |
| klebsiella oxytoca: opportunistic infections in laboratory rodents. | opportunistic pathogens have become increasingly relevant as the causative agents of clinical disease and pathological lesions in laboratory animals. this study was conducted to evaluate the role of klebsiella oxytoca as an opportunistic pathogen in laboratory rodents. therefore, k. oxytoca-induced lesions were studied from 2004 to early 2006 in naturally infected rodent colonies maintained at the jackson laboratory (tjl), bar harbor, usa, the animal research centre (tierforschungszentrum, tfz) ... | 2008 | 18625592 |
| sox9 gene regulation and the loss of the xy/xx sex-determining mechanism in the mole vole ellobius lutescens. | in most mammals, the y chromosomal sry gene initiates testis formation within the bipotential gonad, resulting in male development. sry is a transcription factor and together with sf1 it directly up-regulates the expression of the pivotal sex-determining gene sox9 via a 1.3-kb cis-regulatory element (tesco) which contains an evolutionarily conserved region (ecr) of 180 bp. remarkably, several rodent species appear to determine sex in the absence of sry and a y chromosome, including the mole vole ... | 2012 | 22215485 |
| [glycoprotein hormone cells of the pituitary gland of an iranian rodent (ellobius lutescens th.) identification of thyreotropic and gonadotropic cells and correlation with male hypogenitalism]. | | 2015 | 4649173 |
| visual system of the fossorial mole-lemmings, ellobius talpinus and ellobius lutescens. | ocular regression in subterranean species has been shown to be associated with a number of alterations in the retina and in retinal pathways. in order to examine the consequences of eye reduction, the visual system was studied in two species of the murine genus, ellobius, a specialized fossorial rodent. the axial length of the eye is only 2.2 mm in e. lutescens and 2.9 mm in e. talpinus. the mean soma size of ganglion cells in nissl-stained flatmounts is approximately 10 microns in e. lutescens ... | 1994 | 7962718 |
| genomes of ellobius species provide insight into the evolutionary dynamics of mammalian sex chromosomes. | the x and y sex chromosomes of placental mammals show hallmarks of a tumultuous evolutionary past. the x chromosome has a rich and conserved gene content, while the y chromosome has lost most of its genes. in the transcaucasian mole vole ellobius lutescens, the y chromosome including sry has been lost, and both females and males have a 17,x diploid karyotype. similarly, the closely related ellobius talpinus, has a 54,xx karyotype in both females and males. here, we report the sequencing and asse ... | 2016 | 27510564 |
| natural exceptions to normal gonad development in mammals. | gonads are the only organs with 2 possible developmental pathways, testis or ovary. a consequence of this unique feature is that mutations in genes controlling gonad development give rise not only to gonadal malformation or dysfunction but also to frequent cases of sex reversal, including xy females, xx males and intersexes. most of our current knowledge on mammalian sex determination, the genetic process by which the gonadal primordia are committed to differentiate as either testes or ovaries, ... | 2013 | 22626995 |
| ellobius lutescens: sex determination and sex chromosome. | the mole vole ellobius lutescens is an interesting animal, not only concerning its sex determination mechanism without the y-chromosomal sry gene, that triggers sex determination in nearly all other mammalian species, but also regarding the karyotype with an odd number of chromosomes, being identical in male and female animals. the odd chromosome represents the x chromosome, and therefore, even males do not have a y chromosome. we present an overview of a search for candidate genes of male sex d ... | 2007 | 18391532 |
| the sex determination in ellobius lutescens remains bizarre. | mammalian sex determination and gonad differentiation are the result of a complex interaction of fine-tuned spatial and temporal gene expression with threshold levels of individual genes. the male pathway is initiated by sry. some exceptional mammals determine male sex without the sry gene and even without a y chromosome. ellobius lutescens in this report is one example of this "weird" species. we provide key data on the genomic level that there are no coarse differences in the genomes of male a ... | 2002 | 12438791 |
| exclusion of sox9 as the testis determining factor in ellobius lutescens: evidence for another testis determining gene besides sry and sox9. | in mammals the initiation of testis determination usually depends on the y-chromosomal gene sry. a few species, however, escape from this rule with a testis determination that is independent of sry. the mole vole ellobius lutescens is one of these species. it is not known how testis determination is initiated in this species but it has been suggested that a gene from the sex determination cascade usually acting downstream of sry is mutated and has taken over the testis-determining function. at p ... | 2001 | 11161830 |
| chromosome 9 of ellobius lutescens is the x chromosome. | ellobius lutescens carries an apparently identical karyotype (2n = 17) in both sexes. on the basis of indirect evidence the unpaired chromosome 9 has been considered to represent the x chromosome of this species. we have obtained data to substantiate this view by four different techniques. after fusion of hprt- rag cells with e. lutescens fibroblasts we demonstrated that the enzymes hprt and g6pd are localized on the presumptive x chromosome. by analysis of pachytene figures after silver stainin ... | 1988 | 3280269 |
| further chromosomal studies on ellobius lutescens: heteromorphism of chromosome no. 1 is not associated with sex determination. | twelve animals of the species ellobius lutescens from two generations were studied with various chromosomal banding techniques. this species carries 17 chromosomes in both sexes. in preceding studies chromosomal sex determination was assigned to different structural variants of chromosome no. 1. in the present study, no definite chromosomal basis for sex determination was found. | 1986 | 3536574 |
| ellobius lutescens th. (rhodentia, microtinae): q-, r-, and replication banding patterns. chromosome 1 polymorphism in the male and presumptive heterogamety in the female. | five specimens of ellobius lutescens, four males and one female, were studied by several banding methods. structural polymorphism occurred in the longest chromosome pair of the karyotype of two males: a pericentric inversion in one animal and a paracentric inversion in the other. in the female studied, one chromosome 1 differs from those of the males by a marked elongation of a proximal euchromatic band in the long arm. thus, the female seems to represent the heterogametic sex. chromosome 9 show ... | 1979 | 761476 |
| the leydig cell of a hypogonadic rodent (ellobius lutescens, th.): correlation between ultrastructure and biosynthetic activity. | | 1978 | 743533 |
| testis-determining h-y antigen in xo males of the mole-vole (ellobius lutescens). | the xo sex chromosome constitution has been found in both sexes of the mole-vole (ellobius lutescens) belonging to the rodent family microtinae. this enigmatic species has apparently been enduring a 50% zygotic lethality. the current serological study revealed the presence in xo males and the absence from xo females of h-y (histocompatibility y) antigen. in all the mammalian species studied thus far, the expression of h-y antigen strictly coincided with the presence of testicular tissue and not ... | 1977 | 862027 |
| the g and q banding pattern of ellobius lutescens. a unique case of sex determination in mammals. | the karyotype of the microtine ellobius lutescens th., was analysed using the g and q banding techniques. one of the chromsomes of the first pair has the same bands in both sexes while the other member of the pair is unique to each sex. we propose that the sex determining mechanism of ellobius lutescens is located in these chromosomes. the genetic burden imposed on this species due to this constitution is discussed. | 1976 | 793689 |
| demonstration of the existence of a single morphological type of gonadotrophic cell in ellobius lutescens (microtinae) by an ultrastructural analysis of their development under various physiological and experimental conditions. | ultrastructural studies of pituitaries from ellobius lutescens (immature males and females, adult hypogonadic males, and virgin and pregnant females) show that the gonadotrophic cells are characterized by a lamellar or vacuolar rough endoplasmic reticulum (rer), a spirally-arranged golgi apparatus, elongated mitochondria and secretory granules of variable density and size (150-500 mmu). ultrastructural differences between gonadotrophic cells previously determined by light microscopy correspond t ... | 1976 | 766978 |
| zygotic mortality in ellobius lutescens (rodentia: microtinae). | | 1975 | 1120500 |
| [immunofluorescent localisation of corticotrophic and melanotrophic hormones in the pituitary gland of the rodent ellobius lutescens (th)]. | | 1972 | 4343854 |
| [immunofluorescence demonstration of glycoproteic hormone producing cells in the hypophysis of an iranian rodent, (ellobius lutescens (th): gonadotropic and thyrotropic cells]. | | 1972 | 4339507 |
| studies on the male meiosis of ellobius lutescens th. | | 1968 | 5722743 |
| replication patterns of the unpaired chromosome no. 9 of the rodent ellobius lutescens th. | | 1967 | 6035566 |
| [morphology and histolog of the male genital system of a rodent of iran: ellobius lutescens thomas)]. | | 1967 | 4873981 |
| [new type of chromosomal sex determination in the mammals ellobius lutescens th. and microtus (chilotus) oregoni bachm. (muridae, microtinae)]. | | 1958 | 13574115 |
| brain sexual differentiation and requirement of sry: why or why not? | brain sexual differentiation is orchestrated by precise coordination of sex steroid hormones. in some species, programming of select male brain regions is dependent upon aromatization of testosterone to estrogen. in mammals, these hormones surge during the organizational and activational periods that occur during perinatal development and adulthood, respectively. in various fish and reptiles, incubation temperature during a critical embryonic period results in male or female sexual differentiati ... | 2017 | 29200993 |
| endogenous amdoparvovirus-related elements reveal insights into the biology and evolution of vertebrate parvoviruses. | amdoparvoviruses (family parvoviridae: genus amdoparvovirus) infect carnivores, and are a major cause of morbidity and mortality in farmed animals. in this study, we systematically screened animal genomes to identify endogenous parvoviral elements (epvs) disclosing a high degree of similarity to amdoparvoviruses, and investigated their genomic, phylogenetic and protein structural features. we report the first examples of full-length, amdoparvovirus-derived epvs in the genome of the transcaucasia ... | 2018 | 30443409 |