| [isolation of the lagos-bat virus in the central african republic]. | the second reported isolate of lagos-bat virus has been obtained from bats micropterus pusillus caught in 1974 in the central african empire, thus extending the geographic area of this virus and adding another species of vertebrate host among its reservoirs. | 1977 | 615673 |
| isolation and characterization of 115 street rabies virus isolates from ethiopia by using monoclonal antibodies: identification of 2 isolates as mokola and lagos bat viruses. | there were 115 isolates of rabies viruses recovered by tissue culture technique from 119 animal brains collected in ethiopia. by using 17 selected antinucleocapsid monoclonal antibodies (mabs), 113 isolates were classic street rabies viruses (serotype 1). an isolate of feline origin (eth-16) was a mokola virus (serotype 3) and another isolate (eth-58, obtained from a rabid dog) was serotype 2 (lagos bat virus). none of the 16 antiglycoprotein mabs used neutralized the eth-16 isolate, whereas eth ... | 1992 | 1402044 |
| serological evidence of infection of dogs and man in nigeria by lyssaviruses (family rhabdoviridae). | a survey was conducted for serum neutralizing antibodies against 3 members of the lyssavirus group (rabies, lagos bat and mokola viruses) in nigerian dogs and humans. of 463 unvaccinated dogs sampled, 142 (30.7%) had antibodies against rabies; 39.2% of the stray dogs were positive. of 241 dogs tested, 17.4% had antibodies against mokola virus and 5.8% against lagos bat virus. 28.6% of human samples tested had antibodies against rabies and, of 158 human samples tested, 12 (7.5%) had antibodies ag ... | 1990 | 2096520 |
| from rabies to rabies-related viruses. | antigenic differences between rabies virus strains characterized with monoclonal antibodies presently define at least four serotypes within the lyssavirus genus of the rhabdoviridae family: classical rabies virus strains (serotype 1), lagos bat virus (serotype 2), mokola virus (serotype 3) and duvenhage virus (serotype 4). the wide distribution of rabies-related virus strains (serotypes 2, 3 and 4) and above all, the weak protection conferred by rabies vaccines against some of them (principally ... | 1990 | 2205967 |
| monoclonal antibodies to mokola virus for identification of rabies and rabies-related viruses. | rabies and rabies-related virus strains were studied by using a panel of monoclonal antibodies directed against either nucleocapsid proteins or cell surface antigens of mokola virus (mok-3). each strain was used in parallel to infect cultured cells and mice. then, the patterns of reactivity of the different monoclonal antibodies were determined by the immunofluorescent-antibody staining procedure. on cells, the monoclonal antibodies differentiated fixed rabies virus strains (serotype 1) from rab ... | 1988 | 3068246 |
| immunological relationships between rabies virus and rabies-related viruses studied with monoclonal antibodies to mokola virus. | specific monoclonal antibodies (mab) were prepared against a rabies-related lyssavirus, mokola virus. a strain isolated in the central african republic, mok-3, was used as immunogen. after 3 fusions more than 90 hybridoma cultures secreting mab were identified. according to their different patterns of reactivity against rabies and rabies-related viruses, 61 ascites fluids were obtained. the antibody class was igm for 2 of them and igg for 59. they were specific for one of the 4 major viral prote ... | 1988 | 3207504 |
| efficacy of rabies vaccines against duvenhage virus isolated from european house bats (eptesicus serotinus), classic rabies and rabies-related viruses. | isolates of rabies from separate enzootics can be distinguished by their reactions with panels of monoclonal antibodies (mabs) directed to different sites on the nucleocapsid and glycoproteins of the virus. estimates of antigenic relatedness can be made by comparing similarities among groups. in this manner it can be shown that while classic strains of rabies react with most of the mabs, the rabies related lyssaviruses (mokola, lagos and duvenhage) react with only a few of the mabs and isolates ... | 1988 | 3245296 |
| immunopathologic aspects of infection with lagos bat virus of the rabies serogroup. | | 1974 | 4590821 |
| two african viruses serologically and morphologically related to rabies virus. | lagos bat virus and an isolate from shrews (iban 27377), both from nigeria, were found to be bullet-shaped and to mature intracytoplasmically in association with a distinct matrix. they were related to, but readily distinguishable from, rabies virus and each other by complement fixation and neutralization tests. the three viruses, including rabies, form a subgrouping within the rhabdoviruses. | 1970 | 5530013 |
| lagos bat virus in south africa. | | 1981 | 6111687 |
| rabies-related viruses. | five viruses related to rabies occur in africa. two of these, obodhiang from sudan and kotonkan from nigeria, were found in insects and are only distantly related to rabies virus. the other three are antigenically more closely related to rabies. mokola virus was isolated from shrews in nigeria, lagos bat virus from fruit bats in nigeria, and duvenhage virus from brain of a man bitten by a bat in south africa. the public health significance of the rabies-related viruses was emphasized in zimbabwe ... | 1982 | 6758373 |
| a new isolate of lagos bat virus from the republic of south africa. | | 1982 | 7101406 |
| molecular analysis of rabies-related viruses from ethiopia. | from brain samples collected from domestic animals in ethiopia, two rabies-related viruses were isolated. according to their reactivity pattern with anti-nucleocapsid monoclonal antibodies, they were characterized as lagos bat virus (isolate eth-58) and mokola virus (isolate eth-16). this classification was confirmed by neutralization experiments with mokola and lagos bat specific antisera. two potent anti-rabies vaccines were unable to protect mice against the two rabies-related viruses. in ord ... | 1993 | 7777313 |
| rabies and bats in a rabies-endemic area of southern africa: application of two commercial test kits for antigen and antibody detection. | in southern africa, isolates of rabies-related viruses (i.e. duvenhage virus and lagos bat virus) have been made from insectivorous and frugivorous bats. as no recent formal bat virus survey has been reported in southern africa, a survey of bats in rabies-endemic areas was undertaken. five hundred and forty-seven bats (13 species) were collected from 21 localities in the orange free state, lesotho and the northern cape province. none of the 190 bat sera tested using the "trousse platelia rage" e ... | 1993 | 7970582 |
| molecular diversity of the lyssavirus genus. | the sequence of 5568 nucleotides of the 3' moiety of the mokola virus genome (serotype 3 of lyssaviruses) encompassing the nucleoprotein (n), phosphoprotein, matrix protein, and glycoprotein genes is presented and compared to that of the vaccinal strains of serotype 1. it allowed us to determine consensus sequences derived from the transcriptional start/stop signals and the order of protein conservation (nucleoprotein > matrix protein > phosphoprotein) in lyssaviruses. the sequences of the n gen ... | 1993 | 8386891 |
| [arbovirus circulation in the republic of guinea]. | in 1978-1991 the ussr-guinea virological and microbiological laboratory functioned in kindia, the republic of guinea. arbovirus activity in this country was studied by a number of virologists and other specialists. their personal contribution and achievements in this collaboration are reflected in the present paper. about 74,000 mosquitoes, 100,000 ixodidae ticks, 1,500 wild birds, 2,700 bats, 106 monkeys, and 308 other mammals, 927 blood samples collected from febrile patients were examined in ... | 1996 | 8926934 |
| use of anti-glycoprotein monoclonal antibodies to characterize rabies virus in formalin-fixed tissues. | seventy anti-rabies virus monoclonal antibodies (mabs) were tested for reactivity with rabies and rabies-related viruses in formalin-fixed (ff) tissues. forty-three of the mabs were directed against the glycoprotein and 27 were directed against the nucleocapsid as determined by enzyme immunoassays and neutralization tests. twenty of the anti-glycoprotein mabs and one of the anti-nucleocapsid mabs reacted with the rabies challenge virus strain (cvs) in ff tissue. these 21 mabs were screened again ... | 1999 | 10029326 |
| evidence of two lyssavirus phylogroups with distinct pathogenicity and immunogenicity. | the genetic diversity of representative members of the lyssavirus genus (rabies and rabies-related viruses) was evaluated using the gene encoding the transmembrane glycoprotein involved in the virus-host interaction, immunogenicity, and pathogenicity. phylogenetic analysis distinguished seven genotypes, which could be divided into two major phylogroups having the highest bootstrap values. phylogroup i comprises the worldwide genotype 1 (classic rabies virus), the european bat lyssavirus (ebl) ge ... | 2001 | 11238853 |
| lagos bat virus, south africa. | three more isolates of lagos bat virus were recently recovered from fruit bats in south africa after an apparent absence of this virus for 13 years. the sporadic occurrence of cases is likely due to inadequate surveillance programs for lyssavirus infections among bat populations in africa. | 2006 | 16704795 |
| isolation of lagos bat virus from water mongoose. | a genotype 2 lyssavirus, lagos bat virus (lbv), was isolated from a terrestrial wildlife species (water mongoose) in august 2004 in the durban area of the kwazulu-natal province of south africa. the virus isolate was confirmed as lbv by antigenic and genetic characterization, and the mongoose was identified as atilax paludinosus by mitochondrial cytochrome b sequence analysis. phylogenetic analysis demonstrated sequence homology with previous lbv isolates from south african bats. studies perform ... | 2006 | 17326944 |
| cross-protective and cross-reactive immune responses to recombinant vaccinia viruses expressing full-length lyssavirus glycoprotein genes. | lyssaviruses cause acute, progressive encephalitis in mammals. current rabies vaccines offer protection against the lyssaviruses, with the notable exceptions of mokola virus (mokv), lagos bat virus (lbv) and west caucasian bat virus (wcbv). here we describe the cross-protective and cross-reactive immune responses induced by experimental recombinant vaccinia viruses encoding the glycoprotein genes of rabies virus (rabv), mokv and wcbv, either singly or in dual combinations. constructs expressing ... | 2008 | 17588277 |
| lagos bat virus in kenya. | during lyssavirus surveillance, 1,221 bats of at least 30 species were collected from 25 locations in kenya. one isolate of lagos bat virus (lbv) was obtained from a dead eidolon helvum fruit bat. the virus was most similar phylogenetically to lbv isolates from senegal (1985) and from france (imported from togo or egypt; 1999), sharing with these viruses 100% nucleoprotein identity and 99.8 to 100% glycoprotein identity. this genome conservancy across space and time suggests that lbv is well ada ... | 2008 | 18305130 |
| phylogeny of lagos bat virus: challenges for lyssavirus taxonomy. | lagos bat virus (lbv) belongs to genotype 2 of the lyssavirus genus. the complete nucleoprotein (n), phosphoprotein (p), matrixprotein (m) and glycoprotein (g) genes of 13 lbv isolates were sequenced and phylogenetically compared with other lyssavirus representatives. the results identified three different lineages of lbv. one of these lineages demonstrated sufficient sequence diversity to be considered a new lyssavirus genotype (dakar bat lyssavirus). the suggested quantitative separation of ly ... | 2008 | 18359532 |
| expression, purification and crystallization of a lyssavirus matrix (m) protein. | the matrix (m) proteins of lyssaviruses (family rhabdoviridae) are crucial to viral morphogenesis as well as in modulating replication and transcription of the viral genome. to date, no high-resolution structural information has been obtained for full-length rhabdovirus m. here, the cloning, expression and purification of the matrix proteins from three lyssaviruses, lagos bat virus (lag), mokola virus and thailand dog virus, are described. crystals have been obtained for the full-length m protei ... | 2008 | 18391421 |
| antibodies against lagos bat virus in megachiroptera from west africa. | to investigate the presence of lagos bat virus (lbv)-specific antibodies in megachiroptera from west africa, we conducted fluorescent antibody virus neutralization tests. neutralizing antibodies were detected in eidolon helvum (37%), epomophorus gambianus (3%), and epomops buettikoferi (33%, 2/6) from ghana. these findings confirm the presence of lbv in west africa. | 2008 | 18507903 |
| epidemiology and pathogenicity of african bat lyssaviruses. | lyssaviruses belonging to all four known african lyssavirus genotypes (gts) have been reported and isolated from southafrica over the past few decades. these are: (1) duvenhage virus (gt4), isolated again in 2006 from a human fatality; (2) mokola virus (gt3), isolated irregularly, mostly from cats; (3) lagos bat virus (gt2) continually isolated over the past four years from epomophorus fruit bats and from incidental terrestrial animals and (4) rabies virus (gt1) - with two virus biotypes endemic ... | 2008 | 18634494 |
| rhabdovirus matrix protein structures reveal a novel mode of self-association. | the matrix (m) proteins of rhabdoviruses are multifunctional proteins essential for virus maturation and budding that also regulate the expression of viral and host proteins. we have solved the structures of m from the vesicular stomatitis virus serotype new jersey (genus: vesiculovirus) and from lagos bat virus (genus: lyssavirus), revealing that both share a common fold despite sharing no identifiable sequence homology. strikingly, in both structures a stretch of residues from the otherwise-di ... | 2008 | 19112510 |
| lagos bat virus virulence in mice inoculated by the peripheral route. | lagos bat virus (lbv) constitutes genotype (gt) 2 in the lyssavirus genus. in contrast to the gt1 lyssavirus, rabies virus (rabv), lbv was reported to have markedly reduced levels of peripheral pathogenicity. however, this opinion was based on a study of one isolate of lbv only and the reduction in pathogenicity was essentially attributed to the amino-acid substitution at position 333 of glycoprotein ectodomain. in the present study we have demonstrated that peripheral pathogenicity of represent ... | 2009 | 19144249 |
| peptides that mimic the amino-terminal end of the rabies virus phosphoprotein have antiviral activity. | we wanted to develop a therapeutic approach against rabies disease by targeting the lyssavirus transcription/replication complex. because this complex (nucleoprotein n-rna template processed by the l polymerase and its cofactor, the phosphoprotein p) is similar to that of other negative-strand rna viruses, we aimed to design broad-spectrum antiviral drugs that could be used as a complement to postexposure vaccination and immunotherapy. recent progress in understanding the structure/function of t ... | 2009 | 19706704 |
| a robust lentiviral pseudotype neutralisation assay for in-field serosurveillance of rabies and lyssaviruses in africa. | the inflexibility of existing serological techniques for detection of rabies in surveillance constrains the benefit to be gained from many current control strategies. we analysed 304 serum samples from tanzanian dogs for the detection of rabies antibodies in a pseudotype assay using lentiviral vectors bearing the cvs-11 envelope glycoprotein. compared with the widely used gold standard fluorescent antibody virus neutralisation assay, a specificity of 100% and sensitivity of 94.4% with a strong c ... | 2009 | 19925950 |
| evidence of lagos bat virus circulation among nigerian fruit bats. | during lyssavirus surveillance, 350 brains from four species of fruit bats and one species of insectivorous bat were collected from seven locations in northern nigeria during may to october, 2006. lyssavirus antigen was not detected in the brains, and isolation attempts in mice were unsuccessful. however, serologic tests demonstrated the presence of lyssavirus-neutralizing antibodies in bat sera. of 140 sera tested, 27 (19%) neutralized lagos bat virus, and two of these additionally neutralized ... | 2010 | 20090042 |
| shimoni bat virus, a new representative of the lyssavirus genus. | during 2009, 616 bats representing at least 22 species were collected from 10 locations throughout kenya. a new lyssavirus, named shimoni bat virus (shibv), was isolated from the brain of a dead commerson's leaf-nosed bat (hipposideros commersoni), found in a cave in the coastal region of kenya. genetic distances and phylogenetic reconstructions, implemented for each gene and for the concatenated alignment of all five structural genes (n, p, m, g and l), demonstrated that shibv cannot be identif ... | 2010 | 20138934 |
| long-term survival of an urban fruit bat seropositive for ebola and lagos bat viruses. | ebolaviruses (ebov) (family filoviridae) cause viral hemorrhagic fevers in humans and non-human primates when they spill over from their wildlife reservoir hosts with case fatality rates of up to 90%. fruit bats may act as reservoirs of the filoviridae. the migratory fruit bat, eidolon helvum, is common across sub-saharan africa and lives in large colonies, often situated in cities. we screened sera from 262 e. helvum using indirect fluorescent tests for antibodies against ebov subtype zaire. we ... | 2010 | 20694141 |
| virus neutralising activity of african fruit bat (eidolon helvum) sera against emerging lyssaviruses. | it is likely that phylogroup 2 lyssaviruses circulate within bat reservoirs. we adapted a pseudotype (pt) neutralisation assay (pna) to a multiplex format enabling serosurveillance for lagos bat virus (lbv), mokola virus (mokv) and west caucasian bat virus (wcbv) in a potential reservoir, the african straw-coloured fruit bat, eidolon helvum. highly correlated titres were observed between single and multiplex pnas using ptlbv and ptmokv (r=0.97, p<0.0001), validating its use for bat serosurveilla ... | 2010 | 20951400 |
| laboratory surveillance of rabies in humans, domestic animals, and bats in madagascar from 2005 to 2010. | background. rabies virus (rabv) has circulated in madagascar at least since the 19th century. objectives. to assess the circulation of lyssavirus in the island from 2005 to 2010. materials and methods. animal (including bats) and human samples were tested for rabv and other lyssavirus using antigen, ribonucleic acid (rna), and antibodies detection and virus isolation. results. half of the 437 domestic or tame wild terrestrial mammal brains tested were found rabv antigen positive, including 54% o ... | 2011 | 21991442 |
| Commerson's leaf-nosed bat (Hipposideros commersoni) is the likely reservoir of Shimoni bat virus. | In this study we attempted to identify whether Commerson's leaf-nosed bat (Hipposideros commersoni) is the reservoir of Shimoni bat virus (SHIBV), which was isolated from a bat of this species in 2009. An alternative explanation is that the isolation of SHIBV from H. commersoni was a result of spill-over infection from other species, particularly from the Egyptian fruit bats (Rousettus aegyptiacus), which frequently sympatrically roost with H. commersoni and are known as the reservoir of the phy ... | 2011 | 21867415 |
| [rabies in bats]. | rabies is a zoonosis ending fatally in all mammals, including humans. unlike the other mammals, this disease is usually not fatal in bats. rabies is caused by lyssaviruses which are divided into several distinct phylogroups comprising 15 known viruses. it is believed that the original hosts of all lyssaviruses are bats. classical rabies virus (rabv) occurs in bats across americas and represents the major cause of rabies in humans and domestic animals there. european bat lyssavirus type 1 (eblv-1 ... | 2016 | 27450525 |
| analysis of the complete genome of the first irkut virus isolate from china: comparison across the lyssavirus genus. | the genome of irkut virus, isolate irkv-thchina12, the first non-rabies lyssavirus from china (of bat origin), has been completely sequenced. in general, coding and non-coding regions of this viral genome are similar to those of other lyssaviruses. however, alignment of the deduced amino acid sequences of the structural proteins of irkv-thchina12 with those of other lyssavirus representatives revealed significant variability between viral species. the nucleoprotein and matrix protein were found ... | 2013 | 23872529 |
| cross-neutralization of antibodies induced by vaccination with purified chick embryo cell vaccine (pcecv) against different lyssavirus species. | rabies is a neglected zoonotic disease caused by viruses belonging to the genus lyssavirus. in endemic countries of asia and africa, where the majority of the estimated 60,000 human rabies deaths occur, it is mainly caused by the classical rabies virus (rabv) transmitted by dogs. over the last decade new species within the genus lyssavirus have been identified. meanwhile 15 (proposed or classified) species exist, including australian bat lyssavirus (ablv), european bat lyssavirus (eblv-1 and -2) ... | 2014 | 25483634 |
| serological evidence of lyssaviruses among bats on southwestern indian ocean islands. | we provide serological evidence of lyssavirus circulation among bats on southwestern indian ocean (swio) islands. a total of 572 bats belonging to 22 species were collected on anjouan, mayotte, la réunion, mauritius, mahé and madagascar and screened by the rapid fluorescent focus inhibition test for the presence of neutralising antibodies against the two main rabies related lyssaviruses circulating on the african continent: duvenhage lyssavirus (duvv) and lagos bat lyssavirus (lbv), representing ... | 2016 | 27501458 |
| antigenic characterisation of lyssaviruses in south africa. | there are at least six lyssavirus species that have been isolated in africa, which include classical rabies virus, lagos bat virus, mokola virus, duvenhage virus, shimoni bat virus and ikoma lyssavirus. in this retrospective study, an analysis of the antigenic reactivity patterns of lyssaviruses in south africa against a panel of 15 anti-nucleoprotein monoclonal antibodies was undertaken. a total of 624 brain specimens, collected between 2005 and 2009, confirmed as containing lyssavirus antigen ... | 2014 | 25685866 |
| comparison of pathogenic domains of rabies and african rabies-related lyssaviruses and pathogenicity observed in mice. | several lyssavirus species occur in africa (rabies virus, lagos bat virus, mokola virus, duvenhage virus, shimoni bat virus and ikoma lyssavirus), displaying a high sequence diversity between isolates belonging to the same species. there is limited information about comparative pathogenesis of these african lyssaviruses and this precludes authoritative opinion on the potential public and veterinary health impact. in this study, an analysis of representative african lyssaviruses attempted to corr ... | 2013 | 23718883 |
| exposure to lyssaviruses in bats of the democratic republic of the congo. | lyssavirus infections in the democratic republic of congo are poorly documented. we examined 218 bats. no lyssavirus antigens were detected but lagos bat virus (lbv) neutralizing antibodies (vna) were detected in eidolon helvum and myonycteris torquata . four samples with lbv vna reacted against shimoni bat virus. | 2017 | 28151079 |
| bat trait, genetic and pathogen data from large-scale investigations of african fruit bats, eidolon helvum. | bats, including african straw-coloured fruit bats (eidolon helvum), have been highlighted as reservoirs of many recently emerged zoonotic viruses. this common, widespread and ecologically important species was the focus of longitudinal and continent-wide studies of the epidemiological and ecology of lagos bat virus, henipaviruses and achimota viruses. here we present a spatial, morphological, demographic, genetic and serological dataset encompassing 2827 bats from nine countries over an 8-year p ... | 2016 | 27479120 |
| lagos bat virus transmission in an eidolon helvum bat colony, ghana. | a brain sample of a straw-coloured fruit bat (eidolon helvum) from ghana without evident signs of disease tested positive by generic lyssavirus rt-pcr and direct antigen staining. sequence analysis confirmed the presence of a lagos bat virus belonging to phylogenetic lineage a. virus neutralization tests using the isolate with sera from the same group of bats yielded neutralizing antibodies in 74% of 567 animals. no cross-neutralization was observed against a different lagos bat virus (lineage b ... | 2015 | 26191622 |
| continent-wide panmixia of an african fruit bat facilitates transmission of potentially zoonotic viruses. | the straw-coloured fruit bat, eidolon helvum, is africa's most widely distributed and commonly hunted fruit bat, often living in close proximity to human populations. this species has been identified as a reservoir of potentially zoonotic viruses, but uncertainties remain regarding viral transmission dynamics and mechanisms of persistence. here we combine genetic and serological analyses of populations across africa, to determine the extent of epidemiological connectivity among e. helvum populat ... | 2013 | 24253424 |
| diversity and epidemiology of mokola virus. | mokola virus (mokv) appears to be exclusive to africa. although the first isolates were from nigeria and other congo basin countries, all reports over the past 20 years have been from southern africa. previous phylogenetic studies analyzed few isolates or used partial gene sequence for analysis since limited sequence information is available for mokv and the isolates were distributed among various laboratories. the complete nucleoprotein, phosphoprotein, matrix and glycoprotein genes of 18 mokv ... | 2013 | 24205423 |
| endemic lagos bat virus infection in eidolon helvum. | phylogenetic analyses suggest lyssaviruses, including rabies virus, originated from bats. however, the role of bats in the maintenance, transmission and evolution of lyssaviruses is poorly understood. a number of genetically diverse lyssaviruses are present in africa, including lagos bat virus (lbv). a high seroprevalence of antibodies against lbv was detected in eidolon helvum bats. longitudinal seroprevalence and age-specific seroprevalence data were analysed and capture-mark-recapture (cmr) a ... | 2012 | 22370126 |
| henipavirus neutralising antibodies in an isolated island population of african fruit bats. | isolated islands provide valuable opportunities to study the persistence of viruses in wildlife populations, including population size thresholds such as the critical community size. the straw-coloured fruit bat, eidolon helvum, has been identified as a reservoir for henipaviruses (serological evidence) and lagos bat virus (lbv; virus isolation and serological evidence) in continental africa. here, we sampled from a remote population of e. helvum annobonensis fruit bats on annobón island in the ... | 2012 | 22253928 |
| pathogenesis of bat rabies in a natural reservoir: comparative susceptibility of the straw-colored fruit bat (eidolon helvum) to three strains of lagos bat virus. | rabies is a fatal neurologic disease caused by lyssavirus infection. people are infected through contact with infected animals. the relative increase of human rabies acquired from bats calls for a better understanding of lyssavirus infections in their natural hosts. so far, there is no experimental model that mimics natural lyssavirus infection in the reservoir bat species. lagos bat virus is a lyssavirus that is endemic in straw-colored fruit bats (eidolon helvum) in africa. here we compared th ... | 2018 | 29505617 |
| support for viral persistence in bats from age-specific serology and models of maternal immunity. | spatiotemporally-localised prediction of virus emergence from wildlife requires focused studies on the ecology and immunology of reservoir hosts in their native habitat. reliable predictions from mathematical models remain difficult in most systems due to a dearth of appropriate empirical data. our goal was to study the circulation and immune dynamics of zoonotic viruses in bat populations and investigate the effects of maternally-derived and acquired immunity on viral persistence. using rare ag ... | 2018 | 29497106 |
| sero-surveillance of lyssavirus specific antibodies in nigerian fruit bats (eidolon helvum). | the aetiological agent of rabies is a member of the lyssavirus genus (rhabdoviridae family, order mononegavirales). the disease (rabies) is endemic in many parts of asia and africa and still remains an important public and veterinary health threat. in nigeria, there is a dearth of information on the natural infection and/or exposure of bat species to lyssaviruses. therefore, this study was undertaken to assess the prevalence of rabies virus (rabv) neutralizing antibodies in sera obtained from ba ... | 2017 | 30270884 |
| lagos bat virus infection dynamics in free-ranging straw-colored fruit bats (eidolon helvum). | bats are key species for ecological function, but they are also reservoirs of zoonotic agents, such as lyssaviruses that cause rabies. little is known about the maintenance and transmission of lyssaviruses in bats, although the observation of clinically sick bats, both in experimental studies and wild bats, has at least demonstrated that lyssaviruses are capable of causing clinical disease in bat species. despite this, extensive surveillance for diseased bats has not yielded lyssaviruses, whilst ... | 2017 | 30270883 |
| experimental lagos bat virus infection in straw-colored fruit bats: a suitable model for bat rabies in a natural reservoir species. | rabies is a fatal neurologic disease caused by lyssavirus infection. bats are important natural reservoir hosts of various lyssaviruses that can be transmitted to people. the epidemiology and pathogenesis of rabies in bats are poorly understood, making it difficult to prevent zoonotic transmission. to further our understanding of lyssavirus pathogenesis in a natural bat host, an experimental model using straw-colored fruit bats (eidolon helvum) and lagos bat virus, an endemic lyssavirus in this ... | 2020 | 33320860 |