Publications

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schistosomatium douthitti: carbohydrate metabolism in the adults. 1976185080
pathology and host responses induced by schistosomatium douthitti in the freshwater snail lymnaea catascopium. 1979501127
effects of schistosomatium douthitti infection on the growth, survival, and reproduction of lymnaea catascopium. 1979536609
schistosomatium douthitti: effects of lymnaea catascopium age on susceptibility to infection. 1978668840
schistosomatium douthitti: exposure of lymnaea catascopium to irradiated miracidia. 1978729693
normal development of schistosomatium douthitti in the snail lymnaea catascopium.schistosomatium douthitti miracidia are ingested by lymnaea catascopium snails and penetrate the host's esophageal wall. mother sporocysts develop adjacent to the esophagus and salivary glands. the increase greatly in size, become irregular in shape, and contain daughter sporocysts by 8 days. development of daughter sporocysts is synchronous; most are released from mother sporocysts 16--20 days postexposure. mother sporocysts then collapse, but may persist for the life of the infected snail. som ...1978739317
geographical distribution, hosts, and biology of schistosomatium douthitti (cort, 1914) price, 1931. 1977858105
oograms of schistosomatium douthitti in mice concomitantly infected with fasciola hepatica. 1977915633
environmental temperature and the development of schistosomatium douthitti in mice. 19751185443
the schistosomatium douthitti cercarial elastase is biochemically and structurally distinct from that of schistosoma mansoni.the cercarial acetabular gland proteinase of schistosomatium douthitti, an agent of 'swimmer's itch', has been identified and characterized. like the corresponding proteinase of schistosoma mansoni, it has significant elastase activity and can degrade a model of dermal extracellular matrix. however, unlike the s. mansoni enzyme, it has a higher molecular weight (50,000 versus 30,000), is of a different proteinase class (metallo versus serine), and has no significant primary structure homology to ...19882452979
[karyologic research on trematodes of the family schistosomatidae from northwestern chukota].peculiarities of chromosome sets of 4 schistosome species, parasitic in different mollusks from the chaun lowland were investigated. the karyotype of parthenitae of trichobilharzia sp. 1 (the intermediate host sibirenauta picta) consists of 18 elements, of which the 2nd and 6th pairs are submetacentric-metacentric, the other chromosomes are metacentric. the diploid chromosome set of trichobilharzia sp. 2 (the intermediate host anisus acronicus) includes 16 biarmed units. the first pair of metace ...19892616200
immunocytochemical localization of regulatory peptides in six species of trematode parasites.1. frozen and paraffin sections of six species of trematodes: schistosoma mansoni, s. mattheei, s. japonicum, schistosomatium douthitti, echinostoma paraensei and fasciola hepatica have been incubated with antisera against leu-enkephalin, fmrf-amide, gastrin-17, luteinizing hormone releasing hormone, neurotensin, oxytocin, prolactin, substance p, thyroid stimulating hormone and cholecystokinin, using indirect immunofluorescence and biotin-avidin horseradish peroxidase detection systems. 2. of th ...19882905970
surface maturation in female schistosoma mansoni, s. mattheei and schistosomatium douthitti. 19883372131
cytochemical and biochemical observations on the digestive tracts of digenetic trematodes. v. ultrastructure of schistosomatium douthitti gut. 19694322975
cytochemical and biochemical observations on the digestive tracts of digenetic trematodes. 8. acid phosphatase activity in schistosoma mansoni and schistosomatium douthitti. 19714326591
schistosomatium douthitti: effects of thyroxine. 19744370352
schistosomatium douthitti (cort, 1914) price, 1929 in a porcupine (erethizon dorsatum) in eastern ontario, canada. 19734782273
effects of insulin on schistosomatium douthitti. 19744851755
responses of miracidia of schistosomatium douthitti (cort 1914) to monochromatic light. 19725017321
effects of amino acids and light on the behavior of miracidia of schistosomatium douthitti (cort 1914). 19725038731
an occurrence of schistosomatium douthitti (cort, 1914) price, 1931, in alaska in a new natural definitive host, clethrionomys rutilus (pallas). 19665949735
intergeneric reproductive stimulation and parthenogenesis in schistosoma mansoni.when mice were infected with female cercariae of schistosoma mansoni and male cercariae of schistosomatium douthitti, many mixed pairs formed. the paired females were approximately the same size as those in unisexual infections, far smaller than females paired with s. mansoni males. although the sch. douthitti males possessed well-developed testes, sperm were not found in their female partners, which developed scanty vitelline glands and produced laterally spined eggs typical of s. mansoni. such ...19846504564
identification of sex of schistosome larval stages.sex of schistosoma mansoni cercariae was identified by a c-banding technique; interphase nuclei of females exhibited w-chromatin (heterochromatin of the w chromosome) whereas those of males did not. similar sexual dimorphism was also shown in nuclei of s. mansoni miracidia, sporocysts, and adult worms. cercariae of the following schistosomes could not be sexed by examination of nuclei after the c-band technique: s. japonicum, s. haematobium, and schistosomatium douthitti . the method presented w ...19836674459
infection with schistosomatium douthitti (schistosomatidae) in the meadow vole (microtus pennsylvanicus) in michigan. 19806993643
the pathology of infection with schistosomatium douthitti in the laboratory mouse and the meadow vole, microtus pennsylvanicus. 19817045168
[comparison of the cercarial chaetotaxy of 10 species of schistosomes].the cercarial chaetotaxy permits the differenciation of four groups of schistosomatinae. --schistosomatium douthitti, parasite of stagnicola and lymnaea (lymnaeidae); --schistosoma japonicum, parasite of oncomelania (melaniidae); --schistosoma mansoni and s. rodhaini, parasites of biomphalaria (planorbiinae, bulinidae); --schistosoma haematobium, s. bovis, s. margrebowiei, s. mattheei, s. leiperi and s. intercalatum, parasites of isidora, physopsis and bulinus (bulininae, bulinidae). for the thi ...19827181377
karyotype evolution and sex chromosome differentiation in schistosomes (trematoda, schistosomatidae).the morphology of c-banded metaphase chromosomes has been studied in two hermaphroditic and ten gonochoristic digenetic trematodes (schistosomes). comparison of numbers and morphology of chromosomes indicates that the karyotype of primitive trematodes probably was composed of 10 (or 11) pairs of telocentric or subtelocentric chromosomes, and reduction of chromosome numbers in advanced species resulted from centromeric fusion rather than elimination of chromosomes. observation of heteromorphic ch ...19817327052
larval trematode assemblages in the snail lymnaea stagnalis from southeastern wisconsin.from may through november 1993 and 1994, lymnaea stagnalis appressa were collected from a stream adjacent to cedarburg bog, ozaukee county, wisconsin. observations of cercarial shedding and subsequent dissection of snails revealed a relatively depauperate digenean component community consisting primarily of 3 common species. the most frequently occurring form was the metacercaria of cotylurus flabelliformis. sporocysts and cercariae of this species were rarely observed. snails also harbored spor ...19989576497
schistosome satellite dna encodes active hammerhead ribozymes.using a computer program designed to search for rna structural motifs in sequence databases, we have found a hammerhead ribozyme domain encoded in the smalpha repetitive dna of schistosoma mansoni. transcripts of these repeats are expressed as long multimeric precursor rnas that cleave in vitro and in vivo into unit-length fragments. this rna domain is able to engage in both cis and trans cleavage typical of the hammerhead ribozyme. further computer analysis of s. mansoni dna identified a potent ...19989632772
mechanisms underlying digenean-snail specificity: role of miracidial attachment and host plasma factors.digenetic trematodes usually show a high degree of specificity for their molluscan intermediate hosts. a panel of 4 digenean species (echinostoma paraensei, e. trivolvis, schistosoma mansoni, and schistosomatium douthitti) and 5 snail species (biomphalaria glabrata, helisoma trivolvis, lymnaea stagnalis, stagnicola elodes, and helix aspersa representing 3 gastropod families) was used to assess the relative contributions of miracidial behavior, host plasma osmolality, and host plasma factors in d ...200011128473
a comparative study of mechanisms underlying digenean-snail specificity: in vitro interactions between hemocytes and digenean larvae.a panel of 4 digenetic trematode species (echinostoma paraensei, e. trivolvis, schistosoma mansoni, and schistosomatium douthitti) and 5 snail species (biomphalaria glabrata, helisoma trivolvis, lymnaea stagnalis, stagnicola elodes, and helix aspersa) was examined to determine if known patterns of host specificity could be explained by the tendency of digenean larvae to be bound by snail hemocytes, or by the ability of larvae to influence the spreading behavior of hemocytes. in short-term (1 hr) ...200011128474
cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes.water borne cercaria(ae) of the trematode genus schistosoma rapidly penetrate host skin. a single serine protease activity, cercarial elastase, is deposited in advance of the invading parasite by holocytosis of vesicles from ten large acetabular gland cells. cercarial elastase activity is a composite of multiple isoforms. genes coding for the isoforms can be divided into two classes by amino acid and promoter sequence homology. two of the five genes identified in schistosoma mansoni account for ...200211986325
[study on molecular phylogeny of schistosoma sinensium based on nuclear ribosomal dna].to determine the phylogenetic relationships between schistosoma sinensium and other schistosomatid species using dna sequence data. two segments of the nuclear rdna repeat, the second internal spacer (its2) and large subunit (lsu/12s) were selected for sequencing.200112571964
acquired immunity in mice infected with schistosomatium douthitti. 195212981273
chemotherapy of experimental infections of mice with schistosomatium douthitti, schistosoma mansoni and schistosoma japonicum. 195213011394
duration of acquired immunity of schistosomatium douthitti infections in mice following treatment. 195313022990
experimental infections of rhesus monkeys with schistosomatium douthitti (cort, 1914). 195313109232
maintenance of schistosomatium douthitti (cort, 1914) in the laboratory (trematoda: schistosomatidae). 195413192541
the histopathology of immune and normal mouse skin exposed to cercariae of schistosomatium douthitti (trematoda: schistosomatidae). 195513263648
the histopathology of swimmers' itch. i. the skin lesions of schistosomatium douthitti and gigantobilharzia huronensis in the unsensitized mouse. 195613302403
longevity of miracidia of schistosomatium douthitti. 195613317944
the histopathology of the liver in mice experimentally infected with schistosomatium douthitti. 195713416632
gametogenesis in schistosomatium douthitti (cort) (schistosomatidae: trematoda). 195713429441
the histopathology of experimental infections in mice with schistosomatium douthitti. 195813533732
implantation of schistosomatium douthitti into the eyes of rats. 195813537926
chromosomes in parthenogenetic miracidia and embryonic cercariae of schistosomatium douthitti. 195913663907
studies on schistosomiasis. xvii. non-reciprocal acquired resistance between schistosoma mansoni and schistosomatium douthitti in mice. 196114036452
immunization against schistosoma japonicum in rhesus monkeys by administration of cercariae of schistosomatium douthitti. 196414309966
the influence of light on the emergence of schistosomatium douthitti cercariae from their snail host. 195114841566
a comparison of infections in mice with three species of schistosomes, schistosoma mansoni, schistosoma japonicum and schistosomatium douthitti. 195214885163
hermaphroditic female schistosomatium douthitti (trematoda: schistosomatidae). 195114908773
unisexual infections with schistosomatium douthitti (trematoda). 194720271930
muscles or testes? comparative evidence for sexual competition among dioecious blood parasites (schistosomatidae) of vertebrates.schistosomes, which live as parasitic adults in the blood vessels of mammals, birds and crocodiles, are unique among trematodes because they have separate sexes. several studies have shown that the sex ratio is often biased towards males. sexual dimorphism can be very important in several genera (schistosoma, heterobilharzia, schistosomatium), as larger males grip smaller females in a gynecophoric canal. but not all schistomatid species have developed a gynecophoric canal. it is also striking th ...200010726265
transintegumental glucose uptake in schistosomatium douthitti.the double internal standard isotope method (utilizing both a highly diffusible [h3 water] and a nondiffusible reference isotope [113m-indium bound to ethylene diamine tetra-acetic acid]) was applied in studies of c14 glucose uptake in the rodent blood fluke. schistosomatium douthitti. uptake of c14-l-glucose was minimal and occurred by a diffusional mechanism alone. transintegumental uptake of the stereoisomer c14-d-glucose, corrected for passive adsorption of the solute on the external tegumen ...19817229817
a comparative study of the life-histories of mammalian schistosomes.available data in the literature pertaining to the life-history characteristics of all known species of mammalian schistosomes have been gathered, and correlations between such variables as length of pre-patent period, adult worm size, rate of progeny production and progeny size have been explored. accommodation of the schistosome life-cycle to the constraints imposed by certain host characteristics such as life-expectancy and size is discussed. of the 23 known species of mammalian schistosomes, ...19836359028
schistosomatium douthitti: biochemical and morphological effects of an experimental infection in mice.the pathophysiological changes that occur in mice experimentally infected with schistosomatium douthitti were studied. male icr mice, 6-8 weeks in age, were exposed to 100 cercariae of s. douthitti from infected snails (lymnaea catascopium) and sacrificed weekly for a total of 13 weeks. liver homogenates, serum samples, and histological sections of liver tissue were examined. results showed that body weights of animals with prepatent infections were higher than those of corresponding controls. a ...19883350101
the role of schistosoma mansoni males in feeding and development of female worms.female schistosoma mansoni from unisexual infections have scant pharyngeal musculature, thin intestinal cecal walls, pale and scanty intestinal contents, and lack acidic thiol proteinase digestive enzyme as determined by indirect immunofluorescence using a monoclonal antibody. their intake of host erythrocytes, measured by 51cr labeling, is about one-fourth that of paired adult females, and they appear to be starved. in contrast, paired adult females have heavier pharyngeal musculature and intes ...19873298599
argentophilic papillae of schistosomatium douthitti cercariae (trematoda: schistosomatidae).argentophilic papillae of cercariae of schistosomatium douthitti were studied by light microscopy. the basic number of body papillae was 56, excluding 20 at the anterior tip. the average number of tail papillae was 18. average locations and spatial ranges of body papillae indicate a rather constant pattern. tail papillae showed greater variability in location. twenty papillae (10 on each side) at the anterior tip of cercariae were associated with gland duct openings. two types of papillae were r ...1979480062
differential use of protease families for invasion by schistosome cercariae.schistosomes are parasitic platyhelminths (flatworms) of birds and mammals. as a parasitic disease of humans, schistosomiasis ranks second only to malaria in global importance. schistosome larvae (cercariae) must invade and penetrate skin as an initial step to successful infection of the vertebrate host. proteolytic enzymes secreted from the acetabular glands of cercariae contribute significantly to the invasion process. in this comparative study, we analyzed protease activities secreted by cerc ...200817936488
schistosome infection in deer mice (peromyscus maniculatus): impacts on host physiology, behavior and energetics.animals routinely encounter environmental stressors and may employ phenotypic plasticity to compensate for the costs of these perturbations. parasites represent an ecologically important stressor for animals, which may induce host plasticity. the present study examined the effects of a trematode parasite, schistosomatium douthitti, on deer mouse (peromyscus maniculatus) physiology, behavior and energetics. measures were taken to assess direct parasite pathology as well as potential host plastici ...200617142691
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