| postgenomic taxonomy of human ureaplasmas -- a case study based on multiple gene sequences. | in 2000, the full genome sequence of ureaplasma parvum (previously known as ureaplasma urealyticum) serovar 3 was released. in 2002, after prolonged debate, it was agreed that the former u. urealyticum should be divided into two species -- u. parvum and u. urealyticum. to provide additional support for this decision and improve our understanding of the relationship between these two species, the authors studied four 'core' genes or gene clusters in atcc reference strains of all 14 serovars of u. ... | 2004 | 15388749 |
| experimental amniotic fluid infection in sheep: effects of ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep. | the objective of the study was to determine the effects in late gestation of ureaplasma parvum serovar 3 colonization and the effects, preterm, of u. parvum serovar 6. | 2008 | 18166324 |
| differences in biofilm development and antibiotic susceptibility among clinical ureaplasma urealyticum and ureaplasma parvum isolates. | the aim of this work was to study the ability of clinical isolates of ureaplasma spp. to form biofilms in vitro and to compare the antibiotic susceptibility of sessile cells and their planktonic counterparts. | 2008 | 18753188 |
| alternate phase variation in expression of two major surface membrane proteins (mba and uu376) of ureaplasma parvum serovar 3. | ureaplasma urealyticum and ureaplasma parvum are commensals and pathogens of the human urogenital tract and of newborn infants. there are four distinct u. parvum serovars and 10 distinct u. urealyticum serovars. both species possess a distinct immunodominant variable surface protein, the multiple banded antigen (mba), which shows size variability among isolates as a result of changes in the number of c-terminal repeating units. adjacent to the mba gene (uu375) lies uu376, which was annotated as ... | 2009 | 19220471 |
| ventilation-mediated injury after preterm delivery of ureaplasma parvum colonized fetal lambs. | ureaplasma species are the microorganisms most frequently isolated from women with preterm birth and are associated with an increased risk of bronchopulmonary dysplasia. initiation of ventilation with high tidal volumes (vt) causes lung injury and inflammation. we investigated whether antenatal colonization with ureaplasma parvum serovar 3 (up) would alter the inflammatory response to mechanical ventilation of preterm lambs. merino ewes were given intraamniotic injections of up at 55-d gestation ... | 2010 | 20220549 |
| maternal administration of erythromycin fails to eradicate intrauterine ureaplasma infection in an ovine model. | erythromycin is the standard antibiotic used for treatment of infection with ureaplasma spp. during pregnancy; however, maternally administered erythromycin may be ineffective at eliminating intra-amniotic ureaplasma infections. we examined whether erythromycin would eradicate intra-amniotic ureaplasma infections in pregnant sheep. at gestational day (gd) 50 (term, gd 150), pregnant ewes received intra-amniotic injections of erythromycin-sensitive ureaplasma parvum serovar 3 (n = 16) or 10b medi ... | 2010 | 20610808 |
| inflammation in fetal sheep from intra-amniotic injection of ureaplasma parvum. | bronchopulmonary dysplasia is associated with chorioamnionitis and fetal lung inflammation. ureaplasma species are the bacteria most frequently isolated from chorioamnionitis. very chronic ureaplasma colonization of amniotic fluid causes low-grade lung inflammation and functional lung maturation in fetal sheep. less is known about shorter exposures of the fetal lung. therefore, we hypothesized that ureaplasmas would cause an acute inflammatory response that would alter lung development. singleto ... | 2010 | 20935228 |
| ureaplasma antigenic variation beyond mba phase variation: dna inversions generating chimeric structures and switching in expression of the mba n-terminal paralogue uu172. | phase variation of the major ureaplasma surface membrane protein, the multiple-banded antigen (mba), with its counterpart, the uu376 protein, was recently discussed as a result of dna inversion occurring at specific inverted repeats. two similar inverted repeats to the ones within the mba locus were found in the genome of ureaplasma parvum serovar 3; one within the mba n-terminal paralogue uu172 and another in the adjacent intergenic spacer region. in this report, we demonstrate on both genomic ... | 2010 | 21255110 |
| chronic fetal exposure to ureaplasma parvum suppresses innate immune responses in sheep. | the chorioamnionitis associated with preterm delivery is often polymicrobial with ureaplasma being the most common isolate. to evaluate interactions between the different proinflammatory mediators, we hypothesized that ureaplasma exposure would increase fetal responsiveness to lps. fetal sheep were given intra-amniotic (ia) injections of media (control) or ureaplasma parvum serovar 3 either 7 or 70 d before preterm delivery. another group received an ia injection of escherichia coli lps 2 d prio ... | 2011 | 21784974 |
| inflammation of the fetal ovine skin following in utero exposure to ureaplasma parvum. | there is increasing evidence linking in utero infection and inflammation to preterm birth. many commensal urogenital tract microorganisms, including the mycoplasmas and ureaplasmas, are commonly detected in association with preterm birth. using an ovine model of sterile fetal inflammation, we demonstrated previously that the fetal skin generates a robust inflammatory response following in utero exposure to lipopolysaccharides from escherichia coli. the fetal skin's response to colonization of th ... | 2011 | 22031190 |