| mycobacterium abscessus infection in an owl monkey (aotus trivirgatua). | | 1970 | 4999881 |
| cutaneous infection with mycobacterium abscessus. | cutaneous infection with rapidly growing mycobacteria is uncommon and diagnosis may be difficult. however, the histopathological features are distinctive and may aid diagnosis. the three pathogenic species, mycobacterium fortuitum, m. chelonae and m. abscessus, show major differences in their antimicrobial sensitivities, and species identification is therefore important. we describe a case of infection with m. abscessus, and discuss the clinical and pathological features of such infections, and ... | 1995 | 7772489 |
| mycobacterium abscessus infection in a puncture wound. | | 1972 | 5049661 |
| comparative studies on the taxonomic relationship between mycobacterium abscessus and mycobacterium borstelense. incidence of mycobacterium abscessus in monkeys. | | 1969 | 4986722 |
| [injection abscesses caused by mycobacterium abscessus]. | | 1972 | 4669854 |
| [contamination of endoscopes and endoscope washers by atypical mycobacteria]. | contamination of endoscopes and endoscope washers by atypical mycobacteria was studied. large amounts of atypical mycobacteria were detected with high frequency inside endoscopes and endoscope washers. the species of atypical mycobacteria was mycobacterium chelonae subsp. abscessus. antibacterial-effects of glutaraldehyde against isolated atypical mycobacteria were checked. sufficient antibacterial-effect was not obtained by 2% glutaraldehyde solution for endoscope sterilization. however, after ... | 1992 | 1624823 |
| mycobacterium abscessus osteomyelitis following a plantar puncture wound. | | 1996 | 8879805 |
| comparison of the pathogenicity for mice of mycobacterium fortuitum and mycobacterium abscessus. | the pathogenicity for mice of 12 strains of mycobacterium abscessus was compared with that for 8 strains of m. fortuitum. both species caused lesions in kidneys and produced "spinning disease" resulting from inner ear infections. no major differences in pathogenicity of these two species were demonstrated. strain to strain variation was marked, especially with m. abscessus. for example, 1.6 x 10(6) organisms of strain 11188 of m. abscessus produced death in four of five animals within 42 days, w ... | 1969 | 5370281 |
| mycobacterium abscessus (m. chelonei) infection of the knee joint: report of two cases following intra-articular injection of corticosteroids. | in 2 patients (3 knees) acute infectious arthritis of the knee developed following intra-articular injection of corticosteroids. the pathogenic organism responsible for the infection was found to be mycobacterium abscessus (m. chelonei). diagnostic difficulties were encountered due to the rarity of such infections and elusive identification of the organism with routine laboratory procedures. therapeutic approaches necessitated combined radical surgical procedures together with antituberculosis d ... | 1979 | 477069 |
| a stationary-phase stress-response sigma factor from mycobacterium tuberculosis. | alternative rna polymerase sigma factors are a common means of coordinating gene regulation in bacteria. using pcr amplification with degenerate primers, we identified and cloned a sigma factor gene, sigf, from mycobacterium tuberculosis. the deduced protein encoded by sigf shows significant similarity to sigf sporulation sigma factors from streptomyces coelicolor and bacillus subtilis and to sigb, a stress-response sigma factor, from b. subtilis. southern blot surveys with a sigf-specific probe ... | 1996 | 8610119 |
| chronic otitis media after tympanostomy tube placement caused by mycobacterium abscessus: a new clinical entity? | infections with nontuberculous mycobacteria (ntm) are being identified with increasing frequency, but the otologic manifestations of ntm infection are not well defined. mycobacterium abscessus is a ubiquitous rapidly growing mycobacterium (rgm) known to cause disease by inoculation after trauma. though reported following open heart and breast augmentation surgery, it is not recognized as a cause of sporadic post-tympanostomy tube otorrhea. this report presents detailed clinical information on si ... | 1994 | 8579134 |
| clinical significance, biochemical features, and susceptibility patterns of sporadic isolates of the mycobacterium chelonae-like organism. | mycobacterium chelonae-like organisms are nonpigmented rapidly growing mycobacteria whose clinical significance is unknown. we evaluated 87 sporadic isolates encountered in a clinical laboratory. most isolates (62%) were respiratory; only 2 of 54 (4%) (both from patients with aids) were clinically significant. among 33 nonrespiratory isolates, 20 of 33 (or 61%) were clinically significant. clinical diseases included posttraumatic wound infections and catheter-related sepsis. routine biochemical ... | 1993 | 8308116 |
| dna large restriction fragment patterns of sporadic and epidemic nosocomial strains of mycobacterium chelonae and mycobacterium abscessus. | large restriction fragment (lrf) pattern analysis of genomic dna using pulsed-field gel electrophoresis was performed on three reference strains, 32 sporadic isolates, and 92 nosocomial isolates from 12 epidemics of mycobacterium chelonae and mycobacterium abscessus. only 17 of 30 (57%) unrelated strains of m. abscessus, compared with 10 of 11 (91%) of m. chelonae strains, gave satisfactory dna extractions, with the remainder resulting in highly fragmented dna. drai, asni, xbai, and spei gave sa ... | 1993 | 8253968 |
| [two cases of lung infection due to mycobacterium chelonae subsp. abscessus]. | two cases of lung infection due to mycobacterium chelonae subsp. abscessus are reported. case 1, a 50-year-old female, was a secondary infection-type, and case 2, a 53-year-old female, was a primary infection-type. the 16 cases reported, between the ages of 29 and 76 years, there were 6 males and 10 females. the roentgenographic examinations, revealed that the ratio of the primary and secondary infection-type was 3:1. effective agents for this organism has not been yet confirmed. in the present ... | 1994 | 8176285 |
| mycobacterium abscessus pseudoinfection traced to an automated endoscope washer: utility of epidemiologic and laboratory investigation. | after 15 patients had positive cultures for mycobacterium abscessus without evidence of infection (i.e., pseudoinfection) following endoscopy, retrospective cohort studies of patients undergoing endoscopy and microbiologic sampling of the environment were done to examine potential nosocomial transmission and to identify the source and risk factors for m. abscessus pseudoinfection. in the epidemic period, m. abscessus-positive cultures were significantly more likely to be obtained during bronchos ... | 1994 | 8169416 |
| structures of the glycopeptidolipid antigens of mycobacterium abscessus and mycobacterium chelonae and possible chemical basis of the serological cross-reactions in the mycobacterium fortuitum complex. | mycobacterium abscessus and mycobacterium chelonae, two members of the mycobacterium fortuitum complex, contain five major glycolipids. a combination of nmr spectroscopy, fast atom bombardment mass spectrometry and chemical degradation was used to elucidate their structures. all the compounds belong to the family of glycopeptidolipids. a 6-deoxy-alpha-l-talosyl unit, which may bear one or two acetyl groups, invariably occupies the site of glycosylation on the threonine residue in the various com ... | 1994 | 8025677 |
| the role of mycobacteria other than tuberculosis (mott) in patients with cystic fibrosis. | the purpose of this study was to estimate the frequency of and evaluate the clinical impact of pulmonary mycobacterial infections among cystic fibrosis (cf) patients. 185 cf patients aged 2.2-38.5 years were screened by sputum samples and by intracutaneous skin tests against tuberculin and sensitins produced from mycobacterium chelonae subsp. abscessus, m. avium, m. intracellulare and m. scrofulaceum (the mais complex). the skin tests towards the sensitins in bcg-vaccinated patients (n = 60) wer ... | 1994 | 7855554 |
| recent changes in taxonomy and disease manifestations of the rapidly growing mycobacteria. | rapidly growing mycobacteria are a complex group of environmental organisms that cause human disease. eight taxonomic groups of pathogens are recognized of which three, the mycobacterium chelonae-like organism (mclo) and the two mycobacterium fortuitum third biovariant groups, have yet to receive names pending dna-dna homology studies. clinical disease due to all eight taxons usually consists of skin or soft tissue infections following trauma. nosocomial disease has become increasingly important ... | 1994 | 7698122 |
| successful treatment of mycobacterium abscessus infections with multidrug regimens containing clarithromycin. | | 1995 | 7620048 |
| mycobacterium abscessus infection of a norplant contraceptive implant site. | the authors report a case of mycobacterium abscessus infection of a subdermal levonogestrel implant (norplant) site. the infection lasted 12 weeks and was indolent, skin manifestations were low grade and difficult to detect. culture of exudate samples showed that m. abscessus was the only causative agent. after the implant was removed the patient's arm healed uneventfully without antimycobacterial therapy. the authors recommend that if gram staining of apparently infected material from an implan ... | 1995 | 7497391 |
| occurrence and experimental infection of toads (bufo marinus and b. granulosus) with mycobacterium chelonei subsp. abscessus. | in a survey of 234 amazonian toads and frogs, six strains of mycobacterium chelonei subsp. abscessus were isolated from the liver or spleen of four of 66 bufo marinus (6.1%) and from the kidney or peritoneal fluid of two of 86 b. granulosus (2.3%). there were no histopathological lesions in the viscera of the infected animals. experimental infection of 29 captive b. marinus and b. granulosus, by the intraperitoneal route, with a pooled inoculum of m. chelonei subsp. abscessus caused five deaths ... | 1984 | 6438324 |
| outbreak of injection abscesses due to mycobacterium abscessus. | | 1969 | 5797954 |
| [rapid genetic identification system of mycobacteria]. | rapid colorimetric hybridization method was applied for the identification of mycobacteria and phylogenetic detection and identification system of mycobacteria of polymerase chain reaction method was designed. quantitative dna-dna hybridization in microdilution plate was used to identify 22 mycobacterial species. this method could identify 90% (178 among 194 trials) of clinical isolates within 3 hr. ten percent of clinical isolates did not belong to any of the established 22 species. through thi ... | 1992 | 1294787 |
| iatrogenic outbreak of m. chelonae skin abscesses. | we describe an outbreak of skin lesions due to mycobacterium chelonae subsp. abscessus associated with injections of lidocaine (lignocaine) given by a 'bioenergetic' (a practitioner of alternative medicine) in colombia. the lidocaine carpules and the lesions of the patients yielded mycobacteria with identical biochemical characteristics. using the methodology of sartwell and a case control design we examined the incubation period and assessed risk factors. of 667 potentially exposed individuals, ... | 1996 | 8760958 |
| infection with mycobacterium abscessus associated with intramuscular injection of adrenal cortex extract--colorado and wyoming, 1995-1996. | during march-april 1996, a physician in the denver area administered intramuscular injections of a preparation labeled "adrenal cortex injection" to 69 patients in colorado as part of a weight-loss regimen. as of august 7, a total of 47 (68%) of these persons were reported to have developed abscesses (diameters ranging from 0.5 cm to 4.0 cm) at the site of injection (either gluteal or deltoid muscle). an investigation of these episodes by the physician and the colorado department of public healt ... | 1996 | 8769652 |
| genetic basis for clarithromycin resistance among isolates of mycobacterium chelonae and mycobacterium abscessus. | resistance to clarithromycin among isolates of mycobacterium chelonae and m. abscessus was observed in 18 of 800 (2.3%) patients tested between 1990 and 1995. patients whose isolates were resistant had either disseminated disease or chronic lung disease, and the resistant isolates were recovered after clarithromycin monotherapy. sequencing of the gene coding for the 23s rrna peptidyltransferase region revealed a point mutation involving adenine at position 2058 (38%) or adenine at position 2059 ... | 1996 | 8807061 |
| from the centers for disease control and prevention. infection with mycobacterium abscessus associated with intramuscular injection of adrenal cortex extract--colorado and wyoming, 1995-1996. | | 1996 | 8827955 |
| differentiation between mycobacterium abscessus and mycobacterium borstelense. | | 1970 | 4244292 |
| [atypical acid fast bacilli, group iv rapid growers, with special reference to differentiation of mycobacterium fortuitum from mycobacterium abscessus]. | | 1969 | 5389309 |
| mycobacterium chelonei iatrogenic infections. | we report on two outbreaks of mycobacterium chelonei subsp. abscessus cutaneous infections, which occurred between june 1974 and april 1975 in a series of 24 patients (15 studied bacteriologically) subjected to venous stripping for varicose veins. the source of infection was the aqueous solution of merbromin used in presurgical care. | 1978 | 77278 |
| mycobacterial lung disease in cystic fibrosis: a prospective study. | patients with cystic fibrosis (cf) may be predisposed to airway infections with unusual organisms, such as mycobacteria. the aim of the study was to determine the incidence and clinical picture of mycobacterial infection in cf children. | 1997 | 9109135 |
| relationship of adverse events to serum drug levels in patients receiving high-dose azithromycin for mycobacterial lung disease. | we treated 39 elderly human immunodeficiency virus-noninfected patients with mycobacterium avium complex and/or mycobacterium abscessus lung disease with azithromycin (600 mg daily), given initially as monotherapy. adverse events occurred in 33 of 39 patients (85%) receiving azithromycin alone, most commonly gastrointestinal (gi) symptoms (32 of 39, or 82%) and hearing impairment (10 of 39, or 26%). twenty-four of 39 patients (62%) required a lower dose or withdrawal of the drug. the mean serum ... | 1997 | 9142801 |
| cutaneous infection due to mycobacterium abscessus. a case report. | erythematous nodular and ulcerating skin lesions occurred in a 56-year-old woman treated with chemotherapy and glucocorticosteroids for metastatic breast cancer. subsequent culture yielded mycobacterium abscessus, a facultative pathogen which exists as a saprophyte in the environment and rarely produces clinical disease in humans. this organism is usually relatively resistant to antituberculous as well as a number of other antimicrobial agents. on the basis of in vitro susceptibility results, tr ... | 1997 | 9188876 |
| idiopathic disseminated bacillus calmette-guérin infection: a french national retrospective study. | disseminated bacillus calmette-guérin (bcg) infection after inoculation of live vaccine is considered to result from impaired immunity of the child. however, in half of the cases, regarded as idiopathic, no well-defined immunodeficiency condition can account for the infection. the objective of the present study is to report the prevalence, clinical features, associated infections, and outcomes of children with idiopathic disseminated bcg infection. | 1996 | 8885960 |
| nontuberculous mycobacteria isolates: clinical significance and disease spectrum. | the incidence of diseases caused by nontuberculous mycobacteria (ntm) is increasing worldwide. there has been no previous report regarding the clinical significance and disease spectrum of these bacteria in taiwan. from january 1992 to june 1996, 201 isolates of ntm were recovered from clinical specimens from 143 patients at national taiwan university hospital. we retrospectively studied the clinical records and radiographs of these patients. a total of 86 isolates of ntm were considered clinica ... | 1997 | 9290272 |
| iatrogenic mycobacterium abscessus infection: histopathology of 71 patients. | the histopathology is described of 190 skin biopsies from 71 patients who presented during an epidemic of nodules and abscesses in the periumbilical region and buttocks, secondary to the application of xylocaine injections. positive cultures for mycobacterium abscessus were obtained from the specimens and from the xylocaine solution. the severe inflammatory lesions involved the dermis and the hypodermis and had three main histopathological patterns: (i) granulomatous nodular or diffuse inflammat ... | 1997 | 9292069 |
| rapid identification of mycobacteria to the species level by polymerase chain reaction and restriction enzyme analysis--a case report of corneal ulcer. | we report a case of corneal ulcer caused by nontuberculous mycobacteria which was confirmed by smear and culture. we attempted a new method for the rapid identification of mycobacteria to the species level on the basis of evaluation by the polymerase chain reaction of the gene encoding. the method is involved with restriction enzyme analysis of pcr product obtained with primers common to all mycobacteria. using the restriction enzyme bst eii and hae iii, clinically relevant and other frequent la ... | 1997 | 9348738 |
| strategies used by pathogenic and nonpathogenic mycobacteria to synthesize rrna. | one rrna operon of all mycobacteria studied so far is located downstream from a gene thought to code for the enzyme udp-n-acetylglucosamine carboxyvinyl transferase (unacgct), which is important to cell wall synthesis. this operon has been designated rrnaf for fast-growing mycobacteria and rrnas for slow growers. we have investigated the upstream sequences and promoter activities of rrna operons of typical fast growers which also possess a second rrn (rrnbf) operon and of the rrna operons of the ... | 1997 | 9371439 |
| activities of the glycylcyclines n,n-dimethylglycylamido-minocycline and n,n-dimethylglycylamido-6-demethyl-6-deoxytetracycline against nocardia spp. and tetracycline-resistant isolates of rapidly growing mycobacteria. | susceptibilities to the new semisynthetic tetracycline (tet) compounds n,n-dimethylglycylamido-minocycline (dmg-mino) and n,n-dimethylglycylamido-6-demethyl-6-deoxytetracycline (dmg-dmdot) were compared with those to doxycycline, minocycline, and tet for 198 tet-resistant (tetr) and 33 tet-susceptible (tets) clinical isolates of rapidly growing mycobacteria (rgm) including the mycobacterium fortuitum group, mycobacterium abscessus, mycobacterium chelonae, and mycobacterium mucogenicum and 68 iso ... | 1996 | 8849243 |
| randomly amplified polymorphic dna pcr for comparison of mycobacterium abscessus strains from nosocomial outbreaks. | mycobacterium abscessus is an important cause of water-related nosocomial outbreaks or pseudo-outbreaks. strain comparison has relied on pulsed-field gel electrophoresis (pfge). unfortunately, almost 50% of strains cannot be assessed by this method. we studied 118 strains of m. abscessus previously studied by pfge by randomly amplified polymorphic dna (rapd) pcr, including isolates from eight nosocomial outbreaks. ten random primers were evaluated by using dna prepared by boiling or phenol-chlor ... | 1997 | 9399508 |
| photo quiz. subcutaneous abscess due to mycobacterium abscessus. | | 1998 | 9502442 |
| proposal of mycobacterium peregrinum sp. nov., nom. rev., and elevation of mycobacterium chelonae subsp. abscessus (kubica et al.) to species status: mycobacterium abscessus comb. nov. | we studied the taxonomic positions of the rapidly growing organism mycobacterium fortuitum and phenotypically related organisms. we confirmed that "mycobacterium peregrinum" atcc 14467t (t = type strain) is genetically independent of m. fortuitum atcc 6841t by using various dna hybridization conditions. strains that were genetically identified as "m. peregrinum" were phenotypically differentiated from m. fortuitum atcc 6841t. thus, we propose that "m. peregrinum" should be revived as an independ ... | 1992 | 1581184 |
| infection of epicardial pacemaker wires due to mycobacterium abscessus. | | 1998 | 9502494 |
| collection of three bacterial aerosols by respirator and surgical mask filters under varying conditions of flow and relative humidity. | a variety of respirator filters and surgical masks were challenged with three aerosolized bacteria: mycobacterium abscessus (m.a.) (a rod), staphylococcus epidermidis (s.e.) (a sphere), and bacillus subtilis (b.s.) (a rod). tests were conducted at two flow rates (45 and 85 l./min) and two humidity levels (30 and 70%). aerosols were measured with a total-particle, direct-reading, spectrometer and a viable particle cascade impactor. measurements up- and downstream of the filter or mask were used i ... | 1997 | 9375526 |
| a single 16s ribosomal rna substitution is responsible for resistance to amikacin and other 2-deoxystreptamine aminoglycosides in mycobacterium abscessus and mycobacterium chelonae. | twenty-six clinical isolates of mycobacterium abscessus resistant to amikacin were identified. most isolates were from patients with posttympanostomy tube placement otitis media or patients with cystic fibrosis who had received aminoglycoside therapy. isolates were highly resistant (mics > 1024 microg/ml) to amikacin, kanamycin, gentamicin, tobramycin, and neomycin (all 2-deoxystreptamine aminoglycosides) but not to streptomycin. sequencing of their 16s ribosomal (r) rna revealed that 16 (94%) o ... | 1998 | 9607835 |
| variables affecting results of sodium chloride tolerance test for identification of rapidly growing mycobacteria. | the sodium chloride tolerance test is often used in the identification of rapidly growing mycobacteria, particularly for distinguishing between mycobacterium abscessus and mycobacterium chelonae. this test, however, is frequently unreliable for the identification of some species. in this study we examined the following variables: medium manufacturer, inoculum concentration, and atmosphere and temperature of incubation. results show that reliability is improved if the test and control slants are ... | 1998 | 9620376 |
| an outbreak of post-surgical wound infections due to mycobacterium abscessus. | an outbreak of post-operative wound infections due to mycobacterium abscessus is described. during a 5-month period 45 post-surgical patients developed wound infection, manifested by wound breakdown, cellulitis, and discharge and progressing slowly to suppuration and sinus formation. the majority (43/45) had undergone out-patient operations, and 40 had had surgery in the inguinal region. the source of infection was identified as contaminated tap water. a study revealed serious deficiencies in th ... | 1998 | 9639628 |
| long-term laboratory contamination by mycobacterium abscessus resulting in two pseudo-outbreaks: recognition with use of random amplified polymorphic dna (rapd) polymerase chain reaction. | beginning in 1993, an increase in clinical isolates of mycobacterium abscessus was observed in a single hospital microbiology laboratory. this involved a cluster of four patients in june 1993 and five patients and a quality-control culture of distilled water in may 1994. twenty-three m. abscessus isolates recovered between 1991 and 1996 were compared by random amplified polymorphic dna polymerase chain reaction (rapd-pcr). sixteen of 21 clinical isolates recovered over a 6-year period and the di ... | 1998 | 9675472 |
| hsp65 sequencing for identification of rapidly growing mycobacteria. | partial sequencing of the hsp65 gene was used for the identification of rapidly growing mycobacteria (rgm). a 441-bp fragment (a. telenti, f. marchesi, m. balz, f. bally, e. böttger, and t. bodmer, j. clin. microbiol. 31:175-178, 1993) was amplified and sequenced by an automated fluorescence-based method involving capillary electrophoresis. type strains of 10 rgm species were first studied. each species had a unique nucleotide sequence, distinguishing it clearly from the other species. a panel o ... | 1999 | 9986875 |
| a new rapidly growing mycobacterial species, mycobacterium murale sp. nov., isolated from the indoor walls of a children's day care centre. | scotochromogenic mycobacterial isolates from water-damaged parts of indoor building materials of a children's day care centre represented a phenetically and genetically distinct group of strains. a 16s rdna dendrogram (1243 bp) showed that the closest species to the new strain ma112/96t was mycobacterium abscessus. phylogenetic and phenetic analyses (100 characteristics) grouped the new isolates with m. abscessus, mycobacterium vaccae, mycobacterium aurum and mycobacterium austroafricanum. ribot ... | 1999 | 10028244 |
| report on an outbreak of postinjection abscesses due to mycobacterium abscessus, including management with surgery and clarithromycin therapy and comparison of strains by random amplified polymorphic dna polymerase chain reaction. | an outbreak of postinjection abscesses occurred in barranquilla, colombia, and was associated with local injections of lidocaine given in a single physician's office. over a 5-month period, 350 (18%) of approximately 2,000 injected patients developed localized cutaneous abscesses or cellulitis; of 210 abscess specimens that were cultured, 205 were positive for rapidly growing mycobacteria, subsequently identified as mycobacterium abscessus. the source of the outbreak was not identified. m. absce ... | 1997 | 9195073 |
| infectious crystalline keratopathy and endophthalmitis secondary to mycobacterium abscessus in a monocular patient with stevens-johnson syndrome. | to describe the clinical and laboratory features of infectious crystalline keratopathy and endophthalmitis secondary to mycobacterium abscessus in a patient with stevens-johnson syndrome. | 1999 | 10030567 |
| [two cases of pulmonary disease caused by mycobacterium chelonae subsp. abscessus]. | we encountered two-cases of pulmonary disease caused by m. chelonae subsp. abscessus, [case 1] a 72-year-old man was admitted to the hospital because of fever. he had been observed for one year after being given a diagnosis of pulmonary disease caused by myocobacterium avium complex. sputum examination revealed acid-fast bacilli (gaffky 9). he recovered after administration of clarithromycin (cam) and other drugs. [case 2] a 61-year-old man was admitted to the hospital because of coughing and sp ... | 1996 | 8976085 |
| neurologic manifestations of disseminated infection with mycobacterium abscessus. | mycobacterium abscessus is a ubiquitous, saprophytic organism with low pathogenic potential. the authors describe the previously unreported clinical features of meningitis and native valve endocarditis caused by this rapidly growing atypical mycobacterium. the fatal outcome of this unusual case coincides with the grim prognosis of this disseminated infection and the significant mortality rate associated with neurologic complications of infective endocarditis. | 2001 | 11274327 |
| atypical mycobacterial infection of the orbit. | to describe the clinical presentation and successful management of an orbital infection caused by mycobacterium abscessus, a formerly unrecognized cause of orbital disease after penetrating trauma. | 1995 | 9097803 |
| successful treatment of chronic mycobacterium abscessus otitis media with clarithromycin. | | 1996 | 8866816 |
| multisite reproducibility of results obtained by the broth microdilution method for susceptibility testing of mycobacterium abscessus, mycobacterium chelonae, and mycobacterium fortuitum. | a multicenter study was conducted to assess the interlaboratory reproducibility of broth microdilution testing of the more common rapidly growing pathogenic mycobacteria. ten isolates (four mycobacterium fortuitum group, three mycobacterium abscessus, and three mycobacterium chelonae isolates) were tested against amikacin, cefoxitin, ciprofloxacin, clarithromycin, doxycycline, imipenem, sulfamethoxazole, and tobramycin (m. chelonae only) in four laboratories. at each site, isolates were tested t ... | 1999 | 10325306 |
| preliminary characterization of a mycobacterium abscessus mutant in human and murine models of infection. | the ability to persist in the host after the establishment of infection is an important virulence determinant for mycobacteria. mycobacterium abscessus is a rapidly growing mycobacterial species which causes a variety of clinical syndromes in humans. we have obtained a rough, wild-type human clinical isolate of m. abscessus (m. abscessus-r) and a smooth, attenuated mutant (m. abscessus-s) which spontaneously dissociated from the clinical isolate. we have found that m. abscessus-r is able to pers ... | 1999 | 10456919 |
| radiometric detection of mycobacteria in routine blood cultures. | mycobacterium chelonei subsp. abscessus was detected radiometrically in routine blood cultures. the organism was detected in two patients without the use of special mycobacteriological media. | 1980 | 7012184 |
| improved methods for generation, sampling, and recovery of biological aerosols in filter challenge tests. | in preparation for filter efficiency tests and sampler comparison studies, methods of biological aerosol generation, sampling, and filter recovery were modified from previous studies. methods described include (1) techniques for generating aerosols that reduced nuisance particles to negligible levels and increased the cell culturability of mycobacterium abscessus by 30%, (2) sampling techniques that lowered the detectable range of biological particle size from 0.65 to 0.45 micron and reduced the ... | 1998 | 9586198 |
| in vitro susceptibilities of rapidly growing mycobacteria to telithromycin (hmr 3647) and seven other antimicrobials. | the antimicrobial activities of telithromycin (hmr 3647) and seven other antimicrobials against 94 strains of rapidly growing mycobacteria were determined. telithromycin at a concentration of 1 microg/ml inhibited mycobacterium peregrinum (100%), mycobacterium chelonae (80%), mycobacterium abscessus-mycobacterium mucogenicum (44.4%), and mycobacterium fortuitum (2.1%). all or most strains of m. peregrinum, m. fortuitum, and m. mucogenicum were inhibited by 2 microg of quinolones per ml. | 2000 | 10602744 |
| partial interferon-gamma receptor signaling chain deficiency in a patient with bacille calmette-guérin and mycobacterium abscessus infection. | complete deficiency of either of the two human interferon (ifn)-gamma receptor components, the ligand-binding ifn-gammar1 chain and the signaling ifn-gammar2 chain, is invariably associated with early-onset infection caused by bacille calmette-guérin vaccines and/or environmental nontuberculous mycobacteria, poor granuloma formation, and a fatal outcome in childhood. partial ifn-gammar1 deficiency is associated with a milder histopathologic and clinical phenotype. cells from a 20-year-old health ... | 2000 | 10608793 |
| multisite reproducibility of etest for susceptibility testing of mycobacterium abscessus, mycobacterium chelonae, and mycobacterium fortuitum. | a multicenter study was conducted to assess the inter- and intralaboratory reproducibility of the etest for susceptibility testing of the rapidly growing mycobacteria. the accuracy also was evaluated by comparing etest results to those obtained by broth microdilution. ten isolates (four of the mycobacterium fortuitum group, three of mycobacterium abscessus, and three of mycobacterium chelonae) were tested against amikacin, cefoxitin, ciprofloxacin, clarithromycin, doxycycline, imipenem, and trim ... | 2000 | 10655363 |
| mycobacterium abscessus infection in cystic fibrosis. colonization or infection? | we present a case of a patient with cystic fibrosis who was thought to be colonized with mycobacterium abscessus for 13 yr prior to developing clinically apparent mycobacterial infection. however, histologic evidence indicated that invasive mycobacterial disease was present from the onset. while accepting that chronic endobronchial colonization with atypical mycobacteria may occur in patients with cystic fibrosis, the repeated isolation of mycobacteria from the sputum of these patients should al ... | 2000 | 10673211 |
| novel diagnostic algorithm for identification of mycobacteria using genus-specific amplification of the 16s-23s rrna gene spacer and restriction endonucleases. | a novel genus-specific pcr for mycobacteria with simple identification to the species level by restriction fragment length polymorphism (rflp) was established using the 16s-23s ribosomal rna gene (rdna) spacer as a target. panspecificity of primers was demonstrated on the genus level by testing 811 bacterial strains (122 species in 37 genera from 286 reference strains and 525 clinical isolates). all mycobacterial isolates (678 strains among 48 defined species and 5 indeterminate taxons) were amp ... | 2000 | 10699003 |
| non-tuberculous mycobacterial tenosynovitis: a review. | the clinical characteristics, outcome and treatment of non-tuberculous mycobacterial tenosynovitis are reviewed. from lesions localized in the hand, 10 different species of non-tuberculous mycobacteria have been reported. the most common are mycobacterium marinum and mycobacterium kansasii. other less frequent organisms are mycobacterium avium complex, mycobacterium szulgai, mycobacterium terrae, mycobacterium fortuitum, mycobacterium chelonae, mycobacterium abscessus, mycobacterium malmoense an ... | 1999 | 10482048 |
| abscesses due to mycobacterium abscessus linked to injection of unapproved alternative medication. | an unlicensed injectable medicine sold as adrenal cortex extract (ace*) and distributed in the alternative medicine community led to the largest outbreak of mycobacterium abscessus infections reported in the united states. records from the implicated distributor from january 1, 1995, to august 18, 1996, were used to identify purchasers; purchasers and public health alerts were used to identify patients. purchasers and patients were interviewed, and available medical records were reviewed. vials ... | 1999 | 10511524 |
| cutaneous infections due to nontuberculous mycobacteria: histopathological review of 28 cases. comparative study between lesions observed in immunosuppressed patients and normal hosts. | to evaluate the histopathological features observed in patients with cutaneous infections due to nontuberculous mycobacteria (ntm) and to compare the histopathological patterns observed in immunosuppressed patients and normal hosts. twenty-eight biopsy specimens corresponding to 27 patients with cutaneous infections due to ntm were reviewed. eighteen biopsies corresponded to normal hosts (14 mycobacterium marinum, 2 mycobacterium chelonae, 1 mycobacterium terrae and 1 mycobacterium gordonae) and ... | 2000 | 10728814 |
| eradication of mycobacterium abscessus in a chronically infected patient with cystic fibrosis. | | 2000 | 10973047 |
| molecular characterization of mycobacterium abscessus strains isolated from a hospital outbreak. | | 2000 | 10998394 |
| mycobacterium abscessus peritonitis: a case report. | | 1998 | 10182108 |
| susceptibility testing for mycobacteria. | mycobacterial susceptibility testing is important for the management of patients with tuberculosis and those with disease caused by certain nontuberculous mycobacteria. to help standardize methods used in the clinical microbiology laboratory for testing susceptibility of mycobacteria, the national committee for clinical laboratory standards (nccls) recently updated nccls document m24-t (published in 1995), which is the tentative standard for antimycobacterial susceptibility testing of mycobacter ... | 2000 | 11073754 |
| mycobacterium abscessus infection after facelift surgery: a case report. | | 2000 | 10800917 |
| fatal pulmonary infection due to multidrug-resistant mycobacterium abscessus in a patient with cystic fibrosis. | we report a case of fatal pulmonary infection caused by mycobacterium abscessus in a young patient with cystic fibrosis, who underwent bipulmonary transplantation after a 1-year history of severe lung disease. fifteen days after surgery he developed septic fever with progressive deterioration in lung function. m. abscessus, initially isolated from a pleural fluid specimen, was then recovered from repeated blood samples, suggesting a disseminated nature of the mycobacterial disease. drug suscepti ... | 2001 | 11158161 |
| sporotrichoid dermatosis caused by mycobacterium abscessus from a public bath. | infections caused by nontuberculous mycobacteria (ntm) are usually associated with immunocompromised states. more recently, however, ntm infections are being diagnosed with greater frequency in patients lacking traditional risk factors. however, cutaneous infection with rapidly growing mycobacteria is uncommon, and diagnosis may be difficult. herein we present a case of sporotrichoid dermatosis on both forearms caused by mycobacterium abscessus in a 34-year-old female (case 1). mycobacterium abs ... | 2000 | 10824491 |
| dna polymorphism of mycobacterium abscessus analyzed by infrequent-restriction-site polymerase chain reaction. | mycobacterium abscessus is an important pathogen that has been increasingly associated with many clinical and nosocomial infections. a reliable molecular typing scheme is essential for the epidemiological study of this rapidly growing mycobacterium. pulsed-field gel electrophoresis (pfge), considered to be the gold standard among molecular typing methods, has failed to provide satisfactory results in the molecular typing of this bacterium. a newly developed molecular typing method, infrequent-re ... | 2000 | 11039248 |
| treatment of refractory disseminated mycobacterium abscessus infection with interferon gamma therapy. | | 1999 | 10052395 |
| skin and wound infection by rapidly growing mycobacteria: an unexpected complication of liposuction and liposculpture. the venezuelan collaborative infectious and tropical diseases study group. | to describe 10 patients with skin and soft tissue infection caused by rapidly growing mycobacteria after cosmetic liposuction and liposculpture. | 2000 | 11074697 |
| clarithromycin resistance to mycobacterium abscessus. | | 2001 | 11446360 |
| failure of treatment for chronic mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid. | we report a case of posttraumatic meningitis due to mycobacterium abscessus, treated initially with oral clarithromycin and intravenous amikacin plus intrathecal amikacin. despite cerebrospinal fluid (csf) levels of clarithromycin and amikacin in excess of their in vitro minimum inhibitory concentrations for the organism, the csf cultures remained continuously positive for m. abscessus. to our knowledge, this is the first documented case of m. abscessus meningitis and the first report of measure ... | 2001 | 11486298 |
| disseminated mycobacterium abscessus infection manifesting as fever of unknown origin and intra-abdominal lymphadenitis: case report and literature review. | mycobacterium abscessus is a rapidly growing mycobacterium found in soil and water throughout the world. disease in immunocompetent patients usually consists of localized skin and soft tissue infections. in contrast, disseminated disease is uncommon, usually presents with rash, and almost always occurs in an immunocompromised host. we describe an unusual case of disseminated m. abscessus infection manifesting as fever of unknown origin and intra-abdominal lymphadenitis, but without rash. our pat ... | 2001 | 11173189 |
| diagnosis and management of atypical mycobacterium spp. infections in established laboratory zebrafish (brachydanio rerio) facilities. | two established zebrafish colonies experienced increased mortality and decreased reproductive performance. initial examination of several fish from one facility revealed hyperemic gills, petechia around the opercula, abdominal distention, and emaciation. affected fish had congested liver with inflammation and multifocal hepatic necrosis. large numbers of acid-fast-positive, rod-shaped bacteria were evident in multiple tissues and the blood. mycobacterium fortuitum was subsequently isolated from ... | 2000 | 11200575 |
| comparison of methods for identification of mycobacterium abscessus and m. chelonae isolates. | mycobacterium abscessus and mycobacterium chelonae are two closely related species that are often not distinguished by clinical laboratories despite the fact they cause diseases requiring different treatment regimens. multilocus enzyme electrophoresis, pcr-restriction fragment length polymorphism analysis of the 65-kda heat shock protein gene, biochemical tests, and high-performance liquid chromatography of mycolic acids were used to identify 75 isolates as either m. abscessus or m. chelonae tha ... | 2001 | 11682537 |
| a comparative study of the effects of uvc irradiation on select procaryotic and eucaryotic wound pathogens. | managing wounds infected with a mixture of several types of microorganisms such as bacteria (procaryotes) and fungi (eucaryotes) is a challenging clinical situation. the purpose of this study was to determine the effectiveness of ultraviolet light (uvc) in eradicating select procaryotic and eucaryotic organisms, in both pure culture and mixed cultures in vitro. five replications of each organism or mixture of organisms (10(6) organisms/ml singly or 10(15) organisms/ml mixed culture) were plated. ... | 2000 | 11889731 |
| mycobacterium abscessus empyema in a lung transplant recipient. | non-tuberculous mycobacteria (ntm) have emerged as important pathogens in organ transplant recipients. because ntm pulmonary infections vary in their clinical and radiographic presentations, heightened clinical suspicion is necessary for accurate diagnosis. we report a case of mycobacterium abscessus empyema in a lung transplant recipient. repeated attempts at identifying the organism from a variety of clinical specimens led to the correct diagnosis and treatment. | 2002 | 11897529 |
| mycobacterium immunogenum sp. nov., a novel species related to mycobacterium abscessus and associated with clinical disease, pseudo-outbreaks and contaminated metalworking fluids: an international cooperative study on mycobacterial taxonomy. | pcr-restriction enzyme pattern analysis of a 439 bp hsp65 gene segment identified 113 unique isolates among non-pigmented rapidly growing mycobacteria (rgm) from clinical and environmental sources that failed to match currently recognized species patterns. this group represented 40% of isolates recovered from bronchoscope contamination pseudo-outbreaks, 0% of disease-associated nosocomial outbreaks and 4% of routine clinical isolates of the mycobacterium abscessus/mycobacterium chelonae group su ... | 2001 | 11594606 |
| pathologic quiz case. chronic pneumonia after gastrectomy. pathologic diagnosis: chronic aspiration lipoid pneumonia with mycobacterium abscessus. | | 2001 | 11419993 |
| mycobacterium abscessus: a cutaneous infection in a patient on renal replacement therapy. | we report a 72-year-old man on haemodialysis who presented with multiple abscesses on his lower legs. routine bacterial culture of abscess pus was reported as 'sterile' after 48 h, leading to the suspicion of a mycobacterial infection. skin biopsy taken for mycobacterial microscopy and culture isolated a heavy growth of mycobacterium abscessus. | 2001 | 11488830 |
| large-scale outbreak of infection with mycobacterium chelonae subsp. abscessus after penicillin injection. | an outbreak of infection with mycobacterium chelonae subsp. abscessus after the injection of penicillin in 86 patients attending a factory hospital is reported. the bacterium was isolated both from lids and from the soil where the drug was stored. molecular analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis of whole-cell proteins and plasmids revealed a pattern identical to that of the strains isolated from the wounds. the source of the infections was soil contamination of the ... | 2002 | 12089291 |
| [mycobacterium abscessus infection complicated with diabetes mellitus]. | we report a case of mycobacterium abscessus infection complicated with diabetes mellitus. a 38-year-old man with diabetes mellitus as an underlying disease, was admitted to our hospital because of a productive cough. he had had pulmonary tuberculosis two years before. chest radiography revealed infiltration in both lung apices and chest ct showed a cavitary lesion in the left upper lobe. gaffky 2 was found on a sputum smear. however, in the examination of pcr on sputum, not only m. tuberculosis ... | 2002 | 11925921 |
| a polymorphic region in mycobacterium abscessus contains a novel insertion sequence element. | a polymorphic region was discovered in the genetically uncharacterized opportunistic pathogen mycobacterium abscessus. the region contains a novel 1.7 kb insertion sequence (is) named ismab1. ismab1 contains two complete orfs and one partial orf located in segments with over 80% nucleotide identity to mycobacterium avium is1601 and is999 and to previously unreported is-like elements from mycobacterium smegmatis. the marked similarity within this family of elements is supportive of horizontal tra ... | 2002 | 12368432 |
| pulmonary disease caused by rapidly growing mycobacteria. | the rapidly growing mycobacteria (rgm) differ from slow-growing mycobacteria such as mycobacterium tuberculosis by virtue of their more rapid growth in culture media and their in vitro resistance to standard antituberculosis drugs. the rgm can produce numerous infections including chronic lung disease. the most common causes of pulmonary disease are mycobacterium abscessus and mycobacterium fortuitum. this article reviews the management of patients with lung disease caused by rgm. | 2002 | 12370998 |
| successful treatment with faropenem and clarithromycin of pulmonary mycobacterium abscessus infection. | mycobacterium abscessus accounts for 80% of rapidly growing mycobacterial pulmonary infections and can be lethal. treatment is difficult because of the paucity of effective drugs. we describe a patient with pulmonary m. abscessus infection who was treated with a regimen that included faropenem, a novel oral penem, and clarithromycin. he showed favorable responses to the treatment for more than 12 months. in vitro, faropenem had considerable inhibitory activities against 56 strains of rapidly gro ... | 2002 | 12373490 |
| [recurrent otitis media and mastoiditis due to atypical mycobacteria]. | an eleven-year-old girl was operated on due to right-sided chronic otitis media with effusion. after three months, an impressive enlargement of the mucosal lining developed, for which thorough debridement of the middle ear and mastoid was performed. histological examination revealed a granulomatous inflammation, with negative ziehl-neelsen staining. standard bacteriological cultures revealed no pathogenic micro-organisms. three weeks later the same clinical picture developed, once again followed ... | 2002 | 11925802 |
| bilateral mycobacterium abscessus keratitis after laser in situ keratomileusis. | a 35-year-old man was diagnosed with mycobacterium abscessus keratitis in the left eye 3 weeks after bilateral laser in situ keratomileusis (lasik). infection in the right eye developed 6 weeks after surgery. despite aggressive treatment with topical amikacin and clarithromycin and oral clarithromycin, the infection progressed in both eyes. to improve antibiotic penetration, the lasik flap was removed in both eyes. culture positivity was prolonged; however, after 8 weeks of intensive topical ant ... | 2002 | 11978473 |
| nontuberculous mycobacteria. i: multicenter prevalence study in cystic fibrosis. | nontuberculous mycobacteria (ntm) are potential respiratory pathogens in cystic fibrosis (cf). to assess the species-specific prevalence and risk factors for acquisition, we conducted a prospective, cross-sectional study of the prevalence of ntm and clinical features of patients at 21 u.s. centers. almost 10% of patients with cf who were 10 years or older were included (n = 986). the overall prevalence of ntm in sputum was 13.0% (range by center, 7-24%). mycobacterium avium complex (72%) and myc ... | 2003 | 12433668 |
| mastitis due to mycobacterium abscessus after body piercing. | we describe a patient with granulomatous mastitis due to mycobacterium abscessus that presented as a mass lesion and was associated with a pierced nipple. to our knowledge, this is the first reported case of mastitis due to m. abscessus and the first association of this organism with body piercing. | 2001 | 11389508 |
| forty years of disinfectant failure: outbreak of postinjection mycobacterium abscessus infection caused by contamination of benzalkonium chloride. | benzalkonium chloride (bc) continues to be used as an antiseptic and contributes to serious outbreaks of disease. in july 1999, 6 postinjection joint infections caused by mycobacterium abscessus were reported to the texas department of health (austin). we investigated this outbreak and identified 12 case patients who had been seen by the same physician and who had received an intra-articular or periarticular steroid injection during the period of 1 april through 31 july 1999. m. abscessus was cu ... | 2003 | 12684906 |
| evaluation of a commercial line probe assay for identification of mycobacterium species from liquid and solid culture. | the performance of a commercial line probe assay (lipa) (inno-lipa mycobacteria; innogenetics, belgium) for the detection and identification of mycobacterium species from liquid and solid culture was evaluated at five routine clinical laboratories. the lipa method is based on the reverse hybridization principle, in which the mycobacterial 16s-23s ribosomal rna (rrna) spacer region is amplified by polymerase chain reaction (pcr). amplicons are subsequently hybridized with oligonucleotide probes a ... | 2002 | 12461589 |
| rapidly growing mycobacterial infections after pedicures. | rapidly growing mycobacteria (rgm) can cause a variety of cutaneous and systemic diseases. the causative organisms are typically mycobacterium fortuitum or mycobacterium chelonae (also known as mycobacterium abscessus). primary cutaneous lesions may develop after a variable latent period, from weeks to several months, and usually result from direct inoculation after trauma, from injections, or during surgery via contaminated medical instruments. recently, investigators from the centers for disea ... | 2003 | 12756100 |