| shi-quan-da-bu-tang (ten significant tonic decoction), sqt. a potent chinese biological response modifier in cancer immunotherapy, potentiation and detoxification of anticancer drugs. | shi-quan-da-bu-tang (ten significant tonic decoction), or sqt (juzentaihoto, tj-48) was formulated by taiping hui-min ju (public welfare pharmacy bureau) in chinese song dynasty in ad 1200. it is prepared by extracting a mixture of ten medical herbs (rehmannia glutinosa, paeonia lactiflora, liqusticum wallichii, angelica sinesis, glycyrrhiza uralensis, poria cocos, atractylodes macrocephala, panax ginseng. astragalus membranaceus and cinnamomum cassia) that tone the blood and vital energy, and s ... | 1992 | 1294861 |
| pharmacotherapeutic effects of kuei-chih-fu-ling-wan (keishi-bukuryo-gan) on human uterine myomas. | kuei-chih-fu-ling-wan (keishi-bukuryo-gan; kbg), a traditional chinese herbal remedy contains five components: bark of cinnamomum cassia bl. (lauraceae), root of paeonia lactiflora pall. (paeoniaceae), seed of prunus persica batsch. or p. persiba batsch.var.davidiana maxim. (rosaceae), carpophores of poria cocos wolf. (polyporaceae), and root bark of paeonia suffruticosa andr. (paeoniaceae). this prescription has been frequently used in the treatment of gynecological disorders such as hypermenor ... | 1992 | 1471615 |
| [experimental study on yiqi-huoxue therapy of liver fibrosis]. | the experimental hepatic fibrosis was treated with yiqi (reinforcing qi, yq) huoxue (activating blood circulation, hx) principle which was consisted of astragalus membranaceus, ligusticum wallichii, paeonia lactiflora, etc. after stimulation with ccl4 over four months, the wistar rat developed liver fibrosis. rats were divided into the normal control, the toxifying control, yqhx group and hx group. the experimental period lasted over four months. results: (1) mortality of animal: both toxifying ... | 1992 | 1498545 |
| [the effects of nifedipine, diltiazem, and paeonia lactiflora pall. on atherogenesis in rabbits]. | the effects of nifedipine, diltiazem, and paeonia lactiflora pall (plp) on serum lipids. plasma lipid peroxides (lpo), txb2, and 6-keto-pgf1 alpha in cholesterol-fed rabbits have been investigated. oral administration of nifedipine (15 mg/kg.d), diltiazem (30 mg/kg.d), and plp (5 g/kg.d) caused 60.8%, 45.2%, and 74.2% reduction in the area of atherosclerosis in the aorta respectively. the levels of plasma lpo and txb2 and the contents of cholesterol, phospholipid, and calcium in the intimal-medi ... | 1991 | 1879309 |
| [protective mechanism of salvia miltiorrhiza and paeonia lactiflora for experimental liver damage]. | experimental model of acute liver damage with d-galactosamine was made. thereafter, salvia miltiorrhiza (sm) and paeonia lactiflora (pl) were given to the rats. survival rate of rats and liver coefficient (liver weight/body weight) were observed. changes of alt and bilirubin in serum were detected. level of plasma fibronectin (pfn) was determined at various times. changes of pathological histology under microscope and electron-microscope were observed. the results showed that sm and pl could inc ... | 1991 | 2060049 |
| [effect of fu-zheng qu-xie on gastric disease infected with campylobacter pyloridis]. | chinese herbal medicine and gentamycin were used separately in the treatment of 75 cases of gastric disease by campylobacter pyloridis (cp). surveying the changes of the gastrofiberscope, pathological test, bacteriology and immunology. this study, found that in the chinese herbal medicine group clinical symptoms were obviously improving the effective rate for cp being 80% (24/30), the death rate for cp 30% (9/30), and the effective rate for patho-histological changes 50% (15/30). differences of ... | 1991 | 2065393 |
| [effects of nifedipine and paeonia lactiflora on plasma txb2 and 6-keto-pgf1 alpha in cholesterol-fed rabbits]. | the authors examined the influences of nifedipine and paeonia lactiflora (pl) on plasma lpo, txb2 and 6-keto-pgf1 alpha in cholesterol-fed rabbits. in this study, oral administration of nifedipine (15 mg/kg per day) and pl (0.5 g/kg per day) with 2% cholesterol diet for 15 weeks caused 60.75% and 74.24% reduction in the lesion area of aorta respectively. the levels of plasma lpo, txb2, cholesterol, phospholipid and calcium of the intimalmedia of the aorta in the treated groups were significantly ... | 1990 | 2268930 |
| [effect of an extract of paeonia lactiflora on the blood coagulative and fibrinolytic enzymes]. | paeonia lactiflora with the action of promoting blood circulation and removing blood stasis had been shown to be able to inhibit thrombosis and platelet aggregation, increase fibrinolytic activity and promote thrombolysis. this paper described the influence of the extract of paeonia lactiflora in vitro experiments on prothrombin time (pt), activated partial thromboplastin time (ptt), antithrombin effect, activity of plasminogen and urokinase. the experimental results showed that: (1) the extract ... | 1990 | 2364461 |
| [a preliminary study on the pharmacology of the compound prescription huangqin tang and its component drugs]. | results obtained from the pharmacological experiments demonstrated that the compound prescription huangqin tang and its component drugs, roots of paeonia lactiflora, scutellaria baicalensis and glycyrrhiza uralensis, and the fruit of ziziphus jujuba showed marked anti-inflammatory effect. the compound prescription and its component drugs, except the peony root, possessed significant antispastic effect. antipyretic effect of radix scutellariae, radix glycyrrhizae and huangqin tang was suggested. ... | 1990 | 2390172 |
| [effect of paeonia lactiflora on amylase activity and amylase release from pancreatic acini in rats]. | | 1986 | 2425991 |
| effects of certain herbal medicines on the biotransformation of arachidonic acid: a new pharmacological testing method using serum. | two in vitro experimental systems were compared to evaluate the pharmacological effects of some herbal medicines on the biotransformation of arachidonic acid (aa) using the microsomal fraction of sheep vesicular glands as an enzyme source. the first system involved the addition of serum obtained from rats treated orally with the herbal medicines, while the second system involved the direct addition of herbal medicine extracts to the enzyme medium. both systems were performed in parallel. indomet ... | 1988 | 3138504 |
| effects of a chinese herbal medicine, keishi-bukuryo-gan, on the gonadal system of rats. | keishi-bukuryo-gan (tj-25) is a traditional chinese herbal remedy containing five components: bark of cinnamomum cassia, root of paeonia lactiflora, seed of prunus persica or p. persiba var. davidiana, carpophores of poria cocos and root bark of paeonia suffruticosa. this preparation has been used in the treatment of gynecological disorders such as hypermenorrhea, dysmenorrhea and infertility. in the present study, the effects of tj-25 on plasma levels of luteinizing hormone (lh), follicle-stimu ... | 1988 | 3143030 |
| [experimental and clinical studies on the treatment of pulmonary heart disease and pulmonary hypertension with paeonia lactiflora]. | | 1988 | 3250762 |
| [anticoagulant and fibrinolytic effects of total glycosides of chi-shao (paeonia lactiflora) in rats]. | | 1981 | 6459875 |
| [chemical constituents of paeonia lactiflora pall]. | | 1983 | 6659962 |
| endothelium-dependent vasodilator effect of extract prepared from the roots of paeonia lactiflora on isolated rat aorta. | paeoniae radix (the roots of paeonia lactiflora pallas) is a crude drug that is used in asia and europe to improve blood flow. we studied its vasodilator effect and mechanisms of action in vitro. the extract from paeoniae radix (pre) relaxed prostaglandin f2a-precontracted aortic ring preparations of isolated rat aorta that contained endothelium. relaxation by pre did not occur in specimens without endothelium, and was inhibited by pretreatment with 10(-4) m ng-nitro-1-arginine methyl ester. pae ... | 1996 | 8923810 |
| antihyperglycemic effects of paeoniflorin and 8-debenzoylpaeoniflorin, glucosides from the root of paeonia lactiflora. | paeoniflorin and 8-debenzoylpaeoniflorin were isolated from the dried root of paeonia lactiflora pall. (ranunculaceae). they produced a significant blood sugar lowering effect in streptozotocin-treated rats and had a maximum effect at 25 min after treatment. this hypoglycemic action was also observed in normoglycemic rats only at 1 mg/kg. the antihyperglycemic activity of 8-debenzoylpaeoniflorin seems lower than that of paeoniflorin. plasma insulin was not changed in paeoniflorin-treated normogl ... | 1997 | 9270377 |
| [effect of paeonia lactiflora on platelet cytosolic free calcium and erythrocyte membrane ca(2+)-mg(2+)-atpase activity in hyperlipid rabbits]. | the effect of paeonia lactiflora (pl) on platelet cytosolic free calcium and erythrocyte membrane ca(2+)-mg(2+)-atpase activity in hyperlipid rabbits were observed. results showed the level of platelet cytosolic free calcium in the pl group (276.25 +/- 27.00 nmol/l) was significantly lower than that in the cholesterol group (390.88 +/- 70.00 nmol/l), p < 0.01, the basal and calmodulin-stimulated activities of erythocyte membrane ca(2+)-mg(2+)-atp ase in pl group (0.79 +/- 0.05 mumol.pi-1.mg-1.h- ... | 1996 | 9387724 |
| screening of crude drug extracts for prolyl endopeptidase inhibitory activity. | prolyl endopeptidase (pep, ec 3.4.21.26) is an enzyme to play a role in metabolism of proline-containing neuropeptides, such as vasopressin, substance p and thyrotropin-releasing hormone (trh), which were suggested to be involved with learning and memory processes. then, specific inhibitor of pep is expected to have antiamnesic effects, and thus we screened forty-six water- and methanol-extracts from crude drugs selected on the basis of traditional chinese medicine theory, for flavobacterium pro ... | 1999 | 10439485 |
| effect of extract prepared from the roots of paeonia lactiflora on endothelium-dependent relaxation and antioxidant enzyme activity in rats administered high-fat diet. | this study examined the effect of paeoniae radix (pr) on endothelial function and the activity of superoxide dismutase (sod) of erythrocytes in rats administered a high-fat diet. administration of the extract of pr increased the endothelium-dependent relaxation and the activities of sod compared with high the cholesterol diet group significantly. hypercholesterolaemia induced an increase of endothelial superoxide anion and endothelial dysfunction. paeoniae radix is suggested to have a protective ... | 1999 | 10479767 |
| paeoniflorin reverses guanethidine-induced hypotension via activation of central adenosine a1 receptors in wistar rats. | 1. intravenous injection of paeoniflorin, a glycoside purified from the root of paeonia lactiflora, reversed guanethidine-induced hypotension in wistar rats. 2. pretreatment with the adenosine a1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine inhibited this effect of paeoniflorin in a dose-dependent manner. 3. the action of paeoniflorin was not modified by 8-(p-sulfophenyl)theophylline, the polar antagonist of the adenosine a1 receptor, which is not able to enter the central nervous syst ... | 1999 | 10549407 |
| active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of rhodiola sacra. | the active-oxygen scavenging activity of 70 traditional herbal medicines used in china and japan as nourishing tonics were evaluated by electron spin resonance (esr) technique, in order to evaluate their effectiveness for anti-aging and to search for new active-oxygen scavengers from natural resources. most of the 70 herbal medicines showed scavenging activity with various intensities. areca catechu (methanol extract), dendrobium plicatile (methanol extract), juglans regia (water extract), paeon ... | 1999 | 10616967 |
| [studies on the medicinal plant in the "sambutsu-cho" of bungo province possessed by the kumamoto clan (ii); studies on the medicinal herbs]. | in the previous report, i studied the medicinal trees contained in the sambutsu-cho of the kumamoto clan in bungo province. in this report, i studied the medicinal herbs contained in the same book. there were 259 names in the herbal part. i identified 156 species and found 103 species as the medicinal plants. the ratio of the medicinal plants was 66%. the famous medicinal plants were as follows: atractilodes japonica, platycodon gradiflorum, mentha arvensis var. piperascens, lisospermum erythror ... | 1992 | 11639706 |
| [studies on the medicinal plant in the "sambutsu-cho" of higo province possessed by the kumamoto clan (ii): on the medicina herbs]. | in the previous report, i studied the medicinal trees contained in the sambutsu-cho of the kumamoto clan in higo province. in this report, i studied the medicinal herbs contained in the same book. there were 439 names in the herbal part. i identified 214 species and found 129 species as the medicinal plants. the ratio of the medicinal plants was 60%. the famous medicinal plants were as follows: atractilodes japonica, platycodon grandiflorum, prunella vulgaris var. lilacina, pharbitis nil, cnidiu ... | 1993 | 11639722 |
| cytotoxic and antimutagenic stilbenes from seeds of paeonia lactiflora. | cytotoxic and antimutagenic effects of a novel cis-epsilon-viniferin and five known stilbenes, transresveratrol, trans-epsilon-viniferin, gnetin h, suffruticosols a and b, isolated from the seeds of paeonia lactiflora pall. (paeoniaceae) were determined against five different cancer cell lines, and mutagenicity of n-methyl-n'-nitro-n-nitrosoguanidine (mnng) in salmonella typhimurium ta100, respectively. six stilbenes showed cytotoxic activity in a dose-dependent manner, and especially did potent ... | 2002 | 12135100 |
| [effect of chuanwu and baishao used separately or in combination on adjuvant arthritis in rats]. | to study the effect of chuanwu(aconitum carmichaeli) and baishao(paeonia lactiflora) used separately or in combination on the adjuvant arthritis in rats. | 2000 | 12212105 |
| paeoniae radix, a chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. | paeoniae radix (pr) is the root of traditional chinese herb named paeonia lactiflora pallas, which is commonly used to treat liver diseases in china for centuries. several earlier studies have indicated that pr has anticancer growth activities, however the mechanism underlying these activities was unclear and remained to be elucidated. in this study, we evaluated the molecular mechanism of the effect of pr on human hepatoma cell lines, hepg2 and hep3b. our results showed that the water-extract o ... | 2002 | 12215374 |
| expression of the [beta]-glucuronidase gene in pollen of lily (lilium longiflorum), tobacco (nicotiana tabacum), nicotiana rustica, and peony (paeonia lactiflora) by particle bombardment. | a [beta]-glucuronidase (gus) gene that is under the control of the anther-specific lat52 promoter of tomato (lycopersicon esculentum) and the nopaline synthetase polyadenylation terminator was successfully expressed in pollen of lilium longiflorum, nicotiana tabacum, nicotiana rustica, and paeonia lactiflora using a pneumatic particle gun. the gus gene in plasmid pbi221 was also expressed, to a lesser extent, in pollen of all of these species. the presence of methanol in the substrate solution f ... | 1993 | 12231826 |
| antioxidative activity of resveratrol and its derivatives isolated from seeds of paeonia lactiflora. | seven stilbenes, a new cis-epsilon-viniferin and the six known stilbenes, trans-resveratrol, trans-resveratrol-4'-o-beta-d-glucopyranoside, trans-epsilon-viniferin, gnetin h, and suffruticosol a and b, were isolated and identified from seeds of paeonia lactiflora. the antioxidative activity of these stilbene derivatives was evaluated against the 2-deoxyribose degradation and rat liver microsomal lipid peroxidation induced by the hydroxyl radical generated via a fenton-type reaction. among these ... | 2002 | 12400706 |
| interaction between warfarin and the herbal product quilinggao. | to describe a patient with loss of anticoagulation control and bleeding after consumption of the combination herbal product quilinggao. | 2003 | 12773074 |
| paeonianins a-e, new dimeric and monomeric ellagitannins from the fruits of paeonia lactiflora. | four new dimeric ellagitannins, paeonianins a-d (2-5), were isolated from the fruits of paeonia lactiflora, together with a new ellagitannin monomer, paeonianin e (1). their structures were determined by spectroscopic methods. paeonianins a-d (2-5) are positional isomers formed by condensation of pentagalloyl-beta-d-glucose (8) with 5-desgalloylstachyurin (6) or casuariin (7). paeonianin e is a c-glycosidic ellagitannin having a gallic acid methyl ester moiety at the glucose c-1 position. this i ... | 2003 | 12828458 |
| influence of traditional chinese anti-inflammatory medicinal plants on leukocyte and platelet functions. | the enzymes 5-lipoxygenase and elastase are therapeutic targets in dermatological disorders such as psoriasis. fifteen extracts from traditional chinese medicinal plants used to treat topical inflammations were screened for their inhibitory effect on lipoxygenase, cyclooxygenase and elastase activity in intact leukocytes and platelets. astragalus membranaceus, forsythia suspensa and poria cocos inhibited 5-lipoxygenase, with ic50 values of 141, 80 and 141 microg ml(-1), respectively. the latter ... | 2003 | 14604471 |
| inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity by 1,2,3,4,6-penta-o-galloyl-beta-d-glucose in murine macrophage cells. | activated macrophages express inducible isoforms of nitric oxide synthase (inos) and cyclooxygenase (cox-2), and produce excessive amounts of nitric oxide (no) and prostaglandin e2 (pge2), which play key roles in the processes of inflammation and carcinogenesis. the root of paeonia lactiflora pall., and the root cortex of paeonia suffruticosa andr., are important chinese crude drugs used in many traditional prescriptions. 1,2,3,4,6-penta-o-galloyl-beta-d-glucose (pgg) is a major bioactive consti ... | 2003 | 14609132 |
| pangelin, an antimycobacterial coumarin from ducrosia anethifolia. | the aerial parts of ducrosia anethifolia afforded the monoterpene glucoside 8-debenzoylpaeoniflorin ( 1) and the prenylated furanocoumarin pangelin [5-[2"( r)-hydroxy-3"-methyl-3"-butenyloxy]furocoumarin] ( 2). their structures were determined by extensive 1- and 2-dimensional nmr studies. compound 2 demonstrated activity against a panel of fast growing mycobacteria, namely mycobacterium fortuitum, m. aurum, m. phlei and m. smegmatis and minimum inhibitory concentration (mic) values ranged from ... | 2003 | 14648403 |
| paeoniflorin: an antihyperlipidemic agent from paeonia lactiflora. | paeoniflorin (1), isolated from the methanol extract of paeonia lactiflora, showed a lowering effect on cholesterol level in the experimentally-induced hyperlipidemic rats. paeoniflorin showed a significantly lowering effect of total cholesterol, ldl and triglyceride levels compared with the control group at the dose of 200 and 400 mg/kg, p.o. once a day for 4 weeks. | 2004 | 14693219 |
| resveratrol derivatives potently induce apoptosis in human promyelocytic leukemia cells. | resveratrol has been shown to possess antioxidant and anticancer activities, but little is known on the effect of resveratrol derivatives. recently we have isolated resveratrol and its dimers and trimers from peony (paeonia lactiflora) seeds, and reported their strong antioxidant and cytotoxic activity. in the present study, we have evaluated cellular effects of resveratrol derivatives; viniferin, gnetin h, and suffruticosol b on the proliferation and apoptosis in hl-60 cells in vitro. all resve ... | 2003 | 14749523 |
| a deglucosylated metabolite of paeoniflorin of the root of paeonia lactiflora and its pharmacokinetics in rats. | paeoniflorin is a bioactive monoterpene glucoside in paeoniae radix (pr), the roots of paeonia lactiflora (ranunculaceae). by oral administration to rats with the decoction of pr, the metabolism and pharmacokinetics of paeoniflorin were investigated in this study. a deglucosylated metabolite of paeoniflorin, paeoniflorgenin (pg), in serum was identified based on hplc/ms and nmr spectral data. hplc/uv methods were developed for determining pg in serum and feces suspension. a non-compartment model ... | 2003 | 14750027 |
| effects of paeonia lactiflora root extracts on the secretions of monocyte chemotactic protein-1 and -3 in human nasal fibroblasts. | in the field of oriental medicine, the root of paeonia lactiflora (paeoniae radix) has been prescribed usually to treat the common cold, and it was thought to alleviate upper respiratory infection or nasal inflammation. monocyte chemotactic proteins (mcp)-1 and mcp-3 are known as the most potent chemokines to mediate allergic inflammation. the object of the study was to investigate the effect of paeoniae radix on the release of the chemokines such as mcp-1 and mcp-3. to detect the secretion of m ... | 2004 | 15103673 |
| 1,2,3,4,6-penta-o-galloyl-beta-d-glucose blocks endothelial cell growth and tube formation through inhibition of vegf binding to vegf receptor. | tumor angiogenesis is a critical step for the growth and metastasis of solid tumors. vascular endothelial growth factor (vegf) is the most important angiogenic molecule associated with tumor-induced neovascularization. vegf exerts its activity through binding to its receptor tyrosine kinase, kdr/flk-1, expressed on the surface of endothelial cells. from the screening of medicinal plants, we have identified 1,2,3,4,6-penta-o-galloyl-beta-d-glucose (pgg) from the roots of paeonia lactiflora that i ... | 2004 | 15105050 |
| determination of the effectiveness of components of the herbal medicine toki-shakuyaku-san and fractions of angelica acutiloba in improving the scopolamine-induced impairment of rat's spatial cognition in eight-armed radial maze test. | the improving effects of various components of toki-shakuyaku-san (tss) and fractions isolated from angelica acutiloba radix (toki) on scopolamine-induced spatial memory impairment were investigated in eight-armed radial maze. the scopolamine-induced memory impairment was characterized by prominent increase of error choices in addition to decreased correct choices. toki, cnidium officinale rhizoma (senkyu), poria cocos hoelen (bukuryo), alisma orientale rhizoma (takusha), and atractylodes lancea ... | 2004 | 15351791 |
| in vitro stimulation of granulosa cells by a combination of different active ingredients of unkei-to. | unkei-to is widely used in traditional japanese herbal medicine for its ovulation-inducing effect. in the present study, we investigated the in vivo effects of unkei-to and its compounds on the steroidogenesis and cytokine secretion in human granulosa cells. unkei-to stimulated the secretions of 17beta-estradiol and progesterone from highly luteinized granulosa cells obtained from in vitro fertilization patients; the stimulated effect on estradiol secretion occurred with 0.3 microg/ml, while a s ... | 2004 | 15481646 |
| influence of co-administrated sinomenine on pharmacokinetic fate of paeoniflorin in unrestrained conscious rats. | paeonia lactiflora pall. (ranunculaceae) root and sinomenium acutum rehder and wilson (menispermaceae) stem are two herbs widely used in chinese medicine to treat rheumatoid arthritis. while, in theory, either herb could be used alone, in practice, chinese medicine practitioners prescribe them together. studies on pharmacokinetic interaction between the active constituents of these two herbs (paeoniflorin and sinomenine, respectively) provide empirical evidence to support their clinical practice ... | 2005 | 15848021 |
| total glucosides of paeony suppresses adjuvant arthritis in rats and intervenes cytokine-signaling between different types of synoviocytes. | total glucosides of paeony (tgp) are active compounds extracted from the roots of paeonia lactiflora pall. in this study, we investigated the mechanisms of total glucosides of paeony (tgp) in the treatment of adjuvant arthritis (aa). aa in rats was established. synoviocytes proliferation and activity of il-1 were determined by 3-(4, 5-2dimethylthiazal-2yl) 2, 5-diphenyltetrazoliumbromide (mtt) assay. tumor necrosis factor alpha (tnf-alpha) and prostaglandin e2 (pge2) were measured by radioimmuno ... | 2005 | 16023608 |
| antioxidative constituents from paeonia lactiflora. | the ethanol extract of the peony root (paeonia lactiflora pall, paeoniaceae) as well as its major active components including gallic acid and methyl gallate were evaluated for their protective effects against free radical generation and lipid peroxidation. in addition, the protective effects against hydrogen peroxide-induced oxidative dna damage in a mammalian cell line were examined. the ethanol extracts of the peony root (pres) and its active constituents, gallic acid and methyl gallate, exhib ... | 2005 | 16114491 |
| the effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model. | paeoniflorin and sinomenine, derived from the root of paeonia lactiflora pall. (family ranunculaceae) and the stem of sinomenium acutum rehder & wilson (family menispermaceae), respectively, have been, and are currently, widely used for treatment of rheumatic and arthritic diseases in china and japan. our previous studies demonstrated that sinomenine could significantly improve the bioavailability of paeoniflorin in rats, but the underlying mechanisms remain unknown. the present study aims to in ... | 2006 | 16169700 |
| inhibitory action of l-type ca2+ current by paeoniflorin, a major constituent of peony root, in ng108-15 neuronal cells. | the effects of paeoniflorin, a glycoside isolated from the root of paeonia lactiflora, on ion currents in a mouse neuroblastoma and rat glioma hybrid cell line, ng108-15 were investigated. paeoniflorin (1-300 microm) reversibly produced an inhibition of l-type voltage-dependent ca2+ current (i(ca,l)) in a concentration-dependent manner. paeoniflorin caused no change in the overall shape of the current-voltage relationship of i(ca,l). the ic50 value of paeoniflorin-induced inhibition of i(ca,l) w ... | 2005 | 16243310 |
| antioxidant and antiplatelet effects of dang-gui-shao-yao-san on human blood cells. | dang-gui-shao-yao-san (dgsys) is a mixture of medicinal herbs, which has long been used in traditional chinese medicine for treating anemia and ovulary disorders. its preparation comprises angelicae sinensis (oliv.) diels, ligustucum chuanxiong hort, paeonia lactiflora pall, poria cocos (schw.) wolf, atractylodis macrocephala koidz and alisma orientalis (sam.) juzep. the present study examined the anti-superoxide formation, free radical scavenging and anti-lipid peroxidation activities of dgsys ... | 2005 | 16265987 |
| pharmacokinetic interaction of paeoniflorin and sinomenine: pharmacokinetic parameters and tissue distribution characteristics in rats and protein binding ability in vitro. | the root of paeonia lactiflora and the stem of sinomenium acutum are two herbs widely used in chinese herbal medicine for the treatment of inflammatory and arthritic diseases. studies on the interaction of the active constituents of these herbs, i.e., paeoniflorin and sinomenine, in pharmacokinetic parameters, tissues distribution, and protein binding ability could provide empirical data to support their clinical application. following oral administration to rats, the pharmacokinetic alterations ... | 2005 | 16327213 |
| an hplc/ms method for identifying major constituents in the hypocholesterolemic extracts of chinese medicine formula 'xue-fu-zhu-yu decoction'. | in this paper, hplc-esi-ms technique was used to analyze the hypocholesterolemic extracts of 'xue-fu-zhu-yu decoction', a traditional chinese medicine consisting of six crude drugs (i.e. paeonia lactiflora, ligusticum chuanxiong, citrus aurantium, carthamus tinctorius, prunus persica and bupleurum falcatum). a total of 17 compounds were identified and their plant derivations were also distinguished. nine compounds among them were unambiguously determined as oxypaeoniflorin, amygdalin, albiflorin ... | 2006 | 16345012 |
| paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats. | both moutan cortex of paeonia suffruticosa andrews (mc) and the root of paeonia lactiflora pall (pl) are important traditional chinese herbs used commonly to treat inflammatory and pyretic disorders. paeonol, a common component of mc causes anti-platelet aggregation and scavenges free radicals. therefore, the aim of the present study is to investigate the effects of paeonol on cerebral infarct. a total of 60 male sprague-dawley (sd) rats were studied. an animal model of cerebral infarct was esta ... | 2006 | 16458462 |
| suppressive effects of jcicm-6, the extract of an anti-arthritic herbal formula, on the experimental inflammatory and nociceptive models in rodents. | jcicm-6, the extract of an anti-arthritic herbal formula composed of medicinal herbs of sinomenium acutum, aconitum carmichaeli debx., curcuma longa l., paeonia lactiflora pall., and paeonia suffruticosa andr., was examined in the effectiveness and mechanism in reducing experimentally-induced inflammation and nociception using nine animal models. jcicm-6 was extracted from herbs and purified with amberlite xad-7hp adsorbent resin and analyzed with hplc-fingerprint for quality consistency. in acu ... | 2006 | 16462027 |
| protective effect of paeoniflorin on immunological liver injury induced by bacillus calmette-guerin plus lipopolysaccharide: modulation of tumour necrosis factor-alpha and interleukin-6 mrna. | 1. paeoniflorin is one of the main effective components of the total glucosides of paeony (tgp) extracted from the root of paeonia lactiflora which has been used for gynaecological problems and for cramp, pain and giddiness for over 1,500 years in chinese medicine. anti-inflammatory, antioxidative, antihepatic injury and immunoregulatory activities of tgp have been extensively proved in our laboratory for many years. our present study investigates the effects and mechanisms of paeoniflorin on im ... | 2006 | 16620297 |
| effects and mechanisms of total glucosides of paeony on adjuvant arthritis in rats. | total glucosides of paeony (tgp) is the major active constituent of paeonia lactiflora pall. the present study was carried out to investigate the effects of tgp on adjuvant arthritis (aa) of rat and its possible mechanisms. aa was induced by metatarsal footpad injection with complete freund's adjuvant in male sprague-dawley rats. the secondary inflammatory reaction was evaluated by hind paw swelling, polyarthritis index. activity of interleukin-1 (il-1) was detected by con a-induced thymocytes p ... | 2007 | 17000070 |
| in vitro antiviral activity of 1,2,3,4,6-penta-o-galloyl-beta-d-glucose against hepatitis b virus. | this study examined the antiviral activity of the root of paeonia lactiflora pall. among the solvent fractions of the crude drug, the ethyl acetate fraction showed anti-hepatitis b virus (hbv) activity (ic50, 8.1 microg/ml) in an hbv-producing hepg2.2.15 cell culture system. the active anti-hbv principle was isolated and identified as 1,2,3,4,6-penta-o-galloyl-beta-d-glucose (pgg) from the crude drug by activity-guided fractionation. pgg isolated from p. lactiflora was examined for the inhibitio ... | 2006 | 17015965 |
| [study on quality control of paeonia lactiflora]. | to provide the experimental data for the quality control of paeonia lactiflora a prepared chinese medicinal herb. | 2006 | 17048604 |
| [hplc determination of caffeic acid in herba lycopi]. | to provide experimental data for the quality control of processed paeonia lactiflora, a chinese herbal medicine. | 2006 | 17048622 |
| [application of ftir spectroscopy to the analysis of quality mensuration of paeonia lactiflora pall. from native habitat]. | in the present paper, different mensurations of fourier transform infrared spectra for the analysis of paeonia lactiflora pall. were compared. ftir mensurement was applied to the analysis of quality of xylem and outer layer of paeonia lactiflora pall. from native habitat. the results revealed that the chemical contents are the same in both the xylem and outer layer of paeonia lactiflora pall.. but outer layer has less paeoniflorin and its derivatives than in xylem of paeonia lactiflora pall. dif ... | 2006 | 17112028 |
| effects of methyl gallate on arachidonic acid metabolizing enzymes: cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | methyl gallate (mg) is a medicinal herbal product that is isolated from paeonia lactiflora that inhibits cyclooxygenase-2 (cox-2) dependent phases of prostaglandin d2 (pgd2) generation in bone marrow-derived mast cells (bmmc) in a concentration-dependent manner with an ic50 values of 17.0 microm. this compound also found inhibited the cox-2-dependent conversion of the exogenous arachidonic acid to pgd2 in a dose-dependent manner with an ic50 values of 19.0 microm, using a cox enzyme assay kit. h ... | 2006 | 17121182 |
| [isolation, classification and antimicrobial activity of endophytic actinomycetes from plant leaves]. | leave samples of paeonia lactiflora and trifalium repens were collected from sichuan province and beijing respectively to study their endophytic actinmycetes. after a well-established surface-sterilized procedure, the samples were plated on agar media of twye, hv, yecd, na and wa, followed by incubation at 28 degrees c for 2 - 4 weeks. with the help of light microscope, 15 actinomycetes strains were isolated from the plates. comparison of cultural features and fingerprinting analyses of box-pcr ... | 2006 | 17172028 |
| paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, erk and nuclear factor-kappab signaling pathways. | paeonol (2'-hydroxy-4'-methoxyacetophenone), the main active compound of the traditionally used chinese herb paeonia lactiflora pallas, has anti-inflammatory, antioxidant and cardiovascular protective activities. we studied how the levels of intercellular adhesion molecule-1 (icam-1), one of the key molecules in the development of atherosclerosis, might be affected by paeonol in tumor necrosis factor-alpha (tnf-alpha)-activated human umbilical vein endothelial cells (huvecs). paeonol concentrati ... | 2007 | 17276892 |
| paeoniflorin induced immune tolerance of mesenteric lymph node lymphocytes via enhancing beta 2-adrenergic receptor desensitization in rats with adjuvant arthritis. | paeoniflorin (pae), a monoterpene glucoside, is one of the main bioactive components of total glucosides of paeony (tgp) extracted from the root of paeonia lactiflora. tgp has anti-inflammatory and immunoregulatory effects. in this study, we investigated the effects of pae on inflammatory and immune responses to the mesenteric lymph node (mln) lymphocytes and the mechanisms by which pae regulates beta 2-adrenergic receptor (beta 2-ar) signal transduction in adjuvant arthritis (aa) rats. the onse ... | 2007 | 17386414 |
| effects and mechanisms of extract from paeonia lactiflora and astragalus membranaceus on liver fibrosis induced by carbon tetrachloride in rats. | paeonia lactiflora and astragalus membranaceus are two popular traditional chinese medicines, commonly used in chinese herb prescription to treat liver disease. the extract prepared from the roots of paeonia lactiflora and astragalus membranaceus (pae) demonstrated more excellent hepato-protective activity than the single herbs used individually as indicated in our preliminary studies. the present study was carried out to investigate the effects of pae on liver fibrosis in rats induced by carbon ... | 2007 | 17574357 |
| [effect compound decoction on notoginsenosides in panax notoginseng]. | to explore the effect of compound decoction on notoginsenosides in panax notoginseng. | 2007 | 17655142 |
| antinociceptive effects of systemic paeoniflorin on bee venom-induced various 'phenotypes' of nociception and hypersensitivity. | paeoniflorin (pf), one of the active chemical compounds identified from the root of paeonia lactiflora pall, has been well-established to exhibit various neuroprotective actions in the central nervous system (cns) after long-term daily administration. in the present study, by using the bee venom (bv) model of nociception and hypersensitivity, antinociceptive effects of pf were evaluated by intraperitoneal administration in conscious rats. when compared with saline control, systemic pre- and post ... | 2007 | 17854874 |
| protective effects of guizhi-fuling-capsules on rat brain ischemia/reperfusion injury. | previous studies revealed that guizhi-fuling-capsules (gzflc), a traditional chinese medical (kampo) formulation composed of five kinds of medicinal plants, cinnamomum cassia blume (cinnamomi cortex), paeonia lactiflora pall. (peonies radix), paeonia suffruticosa andrews (moutan cortex), prunus persica batsch (persicae semen), and poria cocos wolf (hoelen), exerts a protective effect against vascular injury and has a protective effect against glutamate- or nitro oxide-mediated neuronal damage. i ... | 2007 | 17895588 |
| elucidation of danzhixiaoyao wan and its constituent herbs on antioxidant activity and inhibition of nitric oxide production. | danzhixiaoyao wan (dw) is a common 10 herbs formulation in china for regulating several clinical conditions affecting women. this research tried to explain one of dw's functions, purging heat, using in vitro pharmacological analyses. the whole formulation and each single herb of dw were compared based on antioxidant activity with the oxygen radical absorbance capacity (orac) assay, and for their inhibitory effect (ie) on nitric oxide (no) production by lipopolysaccharide (lps)-activated raw 264. ... | 2007 | 18227909 |
| the analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats. | paeoniflorin (pf) is one of the principle active ingredients of the root of paeonia lactiflora pall (family ranunculaceae), a chinese herb traditionally used to relieve pain, especially visceral pain. the present study aimed to investigate both the effect of pf on neonatal maternal separation-induced visceral hyperalgesia in rats and the mechanism by which such effect is exerted. a dose-dependent analgesic effect was produced by pf (45, 90, 180, and 360 mg/kg i.p.). centrally administered pf (4. ... | 2008 | 18387856 |
| antiallergic effect of the root of paeonia lactiflora and its constituents paeoniflorin and paeonol. | the root of paeonia lactiflora pall (pl, family paeoniaceae) has been used frequently as an antipyretic and anti-inflammatory agent in traditional medicines of korea, china and japan. to evaluate antiallergic effect of pl, we isolated its main constituents, paeoniflorin and paeonol, and evaluated in vivo their inhibitory effects against passive cutaenous anaphylaxis (pca) reaction induced by ige-antigen complex and scratching behaviors induced by compound 48/80. pl, paeoniflorin and paeonol pote ... | 2008 | 18449501 |
| [the development and evolution of differentiation between radix paeoniae rubra and radix paeoniae alba]. | the root of paeonia lactiflora pall. was differentiated into radix paeoniae rubra and radix paeoniae alba since the southern and northern dynasties, most of which were, by then, sourced from the wild plants of paeonia. in the song dynasty, the differentiation of radix paeoniae rubra and radix paeoniae alba was based on the color of its root, and from yuan to qing dynasty, based on the color of its flower. in modern times, this is based on whether it is cultivated and processed or not. radix paeo ... | 2007 | 18453201 |
| protective effects of paeonia lactiflora pall on hydrogen peroxide-induced apoptosis in pc12 cells. | this study was conducted to examine the antioxidative and neuroprotective effects of paeonia lactiflora pall (ple). total phenolic content of ple was 89.65 mg of gallic acid equivalent per gram of ple. ic(50) values for reducing power, hydrogen peroxide scavenging activity, and 1,1-diphenyl-2-picrylhydrazyl (dpph) radical scavenging activity were 297.57, 3.33, and 32.74 microg, respectively. the protective effect of ple against h(2)o(2)-induced oxidative damage to pc12 cells was investigated by ... | 2008 | 18460804 |
| paeonol inhibits rankl-induced osteoclastogenesis by inhibiting erk, p38 and nf-kappab pathway. | numerous studies have indicated that inflammatory cytokines play a major role in osteoclastogenesis, leading to the bone resorption that is frequently associated with osteoporosis. paeonol (2'-hydroxy-4'-methoxyacetophenone), the main active compound of the traditionally used chinese herb paeonia lactiflora pallas, has anti-inflammatory activity. here we found that paeonol markedly inhibited the receptor activator of nuclear factor kappa b ligand (rankl) plus macrophage colony stimulating factor ... | 2008 | 18495114 |
| [dynamic change of paeoniflorin content in root of paeonia lactiflora growing at duolun county, inner mongolia]. | to explore the dynamic change of paeoniflorin content in root of paeonia lactiflora. | 2008 | 18536456 |
| antidepressant-like effect of ethanol extract from paeonia lactiflora in mice. | the present study investigated the antidepressant effect of ethanol extract of paeonia lactiflora (epl) in mice using forced swim test, tail suspension test, open-field test and reserpine test. our results showed that intragastric administration of epl at the doses of 250 and 500 mg/kg for seven days significantly reduced the duration of immobility in both forced swim test and tail suspension test. epl at the dose of 500 mg/kg was as effective as the positive control (chlorimipramine, 20 mg/kg) ... | 2008 | 18570231 |
| antidepressant-like effect of peony glycosides in mice. | the root part of paeonia lactiflora pall. (ranunculaceae), known as peony, is often used in chinese herbal formulae for the treatment of depression-like disorders. previous studies in our laboratory have shown that an ethanol extract of peony produced antidepressive effects in mouse models of depression. it is well known that peony contains glycosides such as paeoniflorin and albiflorin, yet it remains unclear whether the total glycosides of peony (tgp) are effective. the present study aims to e ... | 2008 | 18687393 |
| protective effect of extract from paeonia lactiflora and astragalus membranaceus against liver injury induced by bacillus calmette-guérin and lipopolysaccharide in mice. | paeonia lactiflora and astragalus membranaceus are two popular traditional chinese medicines, commonly used in chinese herb prescription to treat liver disease. the extract from the roots of p. lactiflora and a. membranaceus demonstrated better hepatoprotective activity than the herbs used individually as shown in our previous studies. the present study was carried out to investigate the effects of p. lactiflora and a. membranaceus extract on immunological liver injury in mice induced by bacillu ... | 2008 | 18816297 |
| effects and mechanisms of total glucosides of paeony on synoviocytes activities in rat collagen-induced arthritis. | the aim of the study was to investigate the effects of tgp, an active compound extracted from the roots of paeonia lactiflora pall, on the activities of synoviocytes in rats with collagen-induced arthritis (cia) and its possible mechanisms. cia was induced in male sprague-dawley (sd) rats immunized with chicken type ii collagen (cii) in freund's complete adjuvant (fca). synoviocytes proliferation was determined by 3-(4, 5-2dimethylthiazal-2yl) 2, 5-diphenyltetrazoliumbromide (mtt) assay. tumor n ... | 2009 | 18977427 |
| paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in icr mice. | in the present study, we examined the supplementation of paeonol extracted from moutan cortex of paeonia suffruticosa andrews (mc) or the root of paeonia lactiflora pall (pl) on reducing oxidative stress, cognitive impairment and neurotoxicity in d-galactose (d-gal)-induced aging mice. the icr mice were subcutaneously injected with d-gal (50 mg/(kg day)) for 60 days and administered with paeonol (50, 100 mg/(kg day)) simultaneously. the results showed that paeonol significantly improved the lear ... | 2009 | 19007942 |
| renoprotective effect of total glucosides of paeony (tgp) and its mechanism in experimental diabetes. | total glucosides of paeony (tgp), extracted from the root of paeonia lactiflora pall, has been shown to have ant-inflammatory and antioxidative actions. the aims of this study were to elucidate the renoprotective effect of tgp and its mechanism in experimental diabetes. streptozotocin-induced diabetic rats were treated with tgp for 8 weeks. treatment with tgp at 50, 100, and 200 mg/kg significantly lowered 24-h urinary albumin excretion rate in diabetic rats. tgp treatment in all doses markedly ... | 2009 | 19151544 |
| effects of peony glycosides on mice exposed to chronic unpredictable stress: further evidence for antidepressant-like activity. | ethnopharmacology relevance: peony, the processed root of paeonia lactiflora pall. (ranunculaceae), is a component herb of many traditional formulae for the treatment of depression-like disorders. | 2009 | 19375493 |
| monoterpene glucosides from paeonia lactiflora. | four new "cage-like" monoterpene glucosides (1-4) were isolated from paeonia lactiflora. the structures of these compounds were established by spectroscopic methods, mainly 1d and 2d nmr, and mass spectrometric analysis. compound 4 exhibited moderate cell-protective activity against hydrogen peroxide-induced pc12 cell damage. | 2009 | 19402674 |
| identification and determination of the major constituents in traditional chinese medicinal formula danggui-shaoyao-san by hplc-dad-esi-ms/ms. | danggui-shaoyao-san (dss), a famous traditional chinese medicine formula consisting of six herbal medicines (paeonia lactiflora, angelica sinensis, ligusticum chuanxiong, poria cocos, atractylodis macrocephalae and rhizoma alismatis), has been used as a classical gynecological remedy in china for centuries. however, its active substances have remained unknown. in this paper, an hplc/dad/esi-ms/ms method was developed for the qualitative and quantitative analysis of the major constituents in dss. ... | 2009 | 19411155 |
| effect of total glucosides of paeony on the expression of nephrin in the kidneys from diabetic rats. | total glucosides of paeony (tgp), extracted from the traditional chinese herb root of paeonia lactiflora pall, have been shown to have a therapeutic role in experimental diabetic nephropathy including albuminuria. recent investigation has identified nephrin, a podocyte-specific transmembrane protein, as a key regulator in the pathogenesis of diabetic albuminuria. the aim of this study was to investigate whether tgp can attenuate albuminuria through prevention of nephrin loss in the experimental ... | 2009 | 19507273 |
| mechanisms of inhibiting proliferation of vascular smooth muscle cells by serum of rats treated with dahuang zhechong pill. | dahuang zhechong pill (dhzcp), a famous and classical chinese herbal prescription, consists of twelve traditional chinese drugs: eupolyphaga sinensis walker., rheum officinale baill., scutellaria baicalensis georgi., glycyrrhiza uralensis fisch., prunus persica batsch., prunus armeniaca l., paeonia lactiflora pall., rehmannia glutinosa libosch., toxicodendron vernicifluum f.a. barkl., tabanus bivittatus mats., hirudo nipponica whitman. and holotrichia diomphalia bates., and is clinically used to ... | 2009 | 19527826 |
| peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor. | the root part of paeonia lactiflora pall. (ranunculaceae), commonly known as peony, is a commonly used chinese herb for the treatment of depression-like disorders. previous studies in our laboratory have demonstrated that total glycosides of peony (tgp) produced antidepressant-like action in various mouse models of behavioral despair. the present study aimed to examine whether tgp could affect the chronic unpredictable mild stress (cums)-induced depression in mice. the mechanism(s) underlying th ... | 2009 | 19596036 |
| [selectivity rank regionalization of paeonia lactiflora based on fuzzy method]. | for optimal adaptive cultivation region selection, we used ecology factors characterized duolun region as model area to carry out the adaptive habitat division of paeonia lactiflora. similar priority comparison of ecology factors.in 91 cities were calculated by fuzzy methods, then, distance of the ecology factors were transferred to spacial model by geography information system (,gis) and modified by soil utilization map of china. the results showed that p. lactiflora were mainly distributed in ... | 2009 | 19623968 |
| analgesic effect of paeoniflorin in rats with neonatal maternal separation-induced visceral hyperalgesia is mediated through adenosine a(1) receptor by inhibiting the extracellular signal-regulated protein kinase (erk) pathway. | paeoniflorin (pf), a chief active ingredient in the root of paeonia lactiflora pall (family ranunculaceae), is effective in relieving colorectal distention (crd)-induced visceral pain in rats with visceral hyperalgesia induced by neonatal maternal separation (nms). this study aimed at exploring the underlying mechanisms of pf's analgesic effect on crd-evoked nociceptive signaling in the central nervous system (cns) and investigating whether the adenosine a(1) receptor is involved in pf's anti-no ... | 2009 | 19664651 |
| androgen modulators from the roots of paeonia lactiflora (paeoniae radix) grown and processed in nara prefecture, japan. | the monoterpene glycoside, 3'-o-galloylpaeoniflorin (1), and four known compounds, 6'-o-galloylalbiflorin (2), pentagalloylglucose (3), 6'-o-benzoylpaeoniflorin (4) and 6'-o-galloylpaeoniflorin (5), were isolated from the roots of paeonia lactiflora that had been grown and processed in nara prefecture, japan, as androgen modulators. their structures were elucidated based on spectroscopic analysis. compounds 2 and 3 showed strong androgen receptor (ar) binding activity (ic(50) values 33.7 and 4.1 ... | 2009 | 19721258 |
| drug-use pattern of chinese herbal medicines in insomnia: a 4-year survey in taiwan. | insomnia is a common complaint in the general population. interest in the use of alternative treatments for insomnia is increasing exponentially and is fairly common in taiwan. we undertook a survey to define the drug utilization patterns of chinese herbal medicines (cm) for insomnia in taiwan. | 2009 | 19753680 |
| effects of total glucosides of paeony on oxidative stress in the kidney from diabetic rats. | tgp, extracted from the traditional chinese herb root of paeonia lactiflora pall, has been shown to have therapeutic effect in experimental diabetic nephropathy. however, its mechanism is not fully understood. in this study, the effects of tgp on oxidative stress were investigated in the kidney of diabetic rats induced by streptozotocin. tgp (50, 100, 200mg/kg) was orally administered once a day for 8 weeks. tgp treatment in all three doses significantly lowered 24 h urinary albumin excretion ra ... | 2010 | 19758795 |
| chemical constituents isolated from paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro. | the methanolic extract of paeonia lactiflora roots significantly protected primary cultures of rat cortical cells exposed to oxidative stress induced by h(2)o(2). seven monoterpenes, paeonilactone-b (1), paeonilactone-c (2), paeoniflorigenone (3), benzoylpaeoniflorin (4), paeoniflorin (5), oxypaeoniflorin (6) and albiflorin (7), were isolated by bioactivity-guided fractionation and further separation using chromatographic techniques. among them, compounds 2 and 4 significantly protected primary ... | 2009 | 19772486 |
| two new galloylated monoterpene glycosides, 4-o-galloylalbiflorin and 4'-o-galloylpaeoniflorin, from the roots of paeonia lactiflora (paeoniae radix) grown and processed in nara prefecture, japan. | two new galloylated monoterpene glycosides, 4-o-galloylalbiflorin and 4'-o-galloylpaeoniflorin, were isolated from the roots of paeonia lactiflora that had been grown and processed in nara prefecture, japan. their structures were elucidated based on spectroscopic analysis. these compounds showed androgen receptor (ar) binding activity. | 2009 | 19801879 |
| total glucosides of paeonia lactiflora pall inhibit vascular endothelial growth factor-induced angiogenesis. | to evaluate the anti-angiogenesis effect of total glucosides of paeonia lactiflora pall. | 2010 | 19914370 |
| pharmacokinetic comparisons of typical constituents in white peony root and sulfur fumigated white peony root after oral administration to mice. | white peony root and sulfur fumigated white peony root are produced by different processing methods from the root of paeonia lactiflora pall, but the two traditional chinese medicines are used under the same common name white peony root. in order to clarify the influence of sulfur fumigation on pharmacokinetics of the main monoterpene glucoside components in white peony root, an investigation was carried out to compare the pharmacokinetics of sodium paeoniflorin sulfonate (1) and paeoniflorin (2 ... | 2010 | 20051256 |
| metabolomics study on the anti-depression effect of xiaoyaosan on rat model of chronic unpredictable mild stress. | ethnopharmacology: xiaoyaosan, a famous chinese prescription, composed of poria (poria cocos (schw.) wolf), radix paeoniae alba (paeonia lactiflora pall.), radix glycyrrhizae (glycyrrhiza uralensis fisch.), radix bupleuri (bupleurum chinense dc.), radix angelicae sinensis (angelica sinensis (oliv.) diels), rhizoma atractylodis macrocephalae (atractylodes macrocephala koidz.), herba menthae (mentha haplocalyx briq.), and rhizoma zingiberis recens (zingiber officinale rosc.), has been widely used ... | 2010 | 20079416 |
| the anti-inflammatory effect of paeoniflorin on cerebral infarction induced by ischemia-reperfusion injury in sprague-dawley rats. | paeoniflorin, a component in paeonia lactiflora pall, inhibits nuclear factor-kappab expression in chronic hypoperfusion rat and has anti-inflammatory properties. therefore, the aim of the present study was to investigate the effect of paeoniflorin on cerebral infarct, and the involvement of anti-inflammation. we established an animal model of cerebral infarct by occluding both the common carotid arteries and the right middle cerebral artery for 90 min, followed by reperfusion of 24 hours. the r ... | 2010 | 20128044 |
| long-term treatment with peony glycosides reverses chronic unpredictable mild stress-induced depressive-like behavior via increasing expression of neurotrophins in rat brain. | the root part of paeonia lactiflora pall., commonly known as peony, is a commonly used chinese herb for the treatment of depression-like disorders. previous studies in our laboratory have showed that total glycosides of peony (tgp) produced antidepressant-like action in various mouse models of behavioral despair. the present study aimed to investigate the mechanism(s) underlying the antidepressant-like action of tgp by measuring neurotrophins including brain-derived neurotrophic factor (bdnf) an ... | 2010 | 20176057 |
| qi-shao-shuang-gan, a combination of astragalus membranaceus saponins with paeonia lactiflora glycosides, ameliorates polymicrobial sepsis induced by cecal ligation and puncture in mice. | the present study was performed to investigate the anti-septic effects of qi-shao-shuang-gan (qssg), a combination of astragalus membranaceus saponins (sam) and paeonia lactiflora glycosides (gpl), in septic mice induced by cecal ligation and puncture. qssg was shown to elevate the survival rate of mice, decrease infiltration of polymorphonuclear leukocytes into livers and lungs, lower serum levels of myeloperoxidase, nitric oxide, and lactate dehydrogenase, and decrease mrna expressions of indu ... | 2011 | 20237952 |
| the effects of paeoniflorin on lps-induced liver inflammatory reactions. | paeoniflorin (pf), a monoterpene glucoside, is a primary bioactive component of paeony, the root extract of paeonia lactiflora. we tested the antioxidant effects of pf and its ability to prevent lipopolysaccharide (lps)-induced oxidative stress. we intraperitoneally administered pf (2.5, 5, or 10 mg/kg) to rats for 20 days. on day 21, we injected the rats with lps 4 h before sacrifice and measured serum levels of glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, lactate dehyd ... | 2010 | 20607502 |
| bioactivity-guided isolation of 1,2,3,4,6-penta-o-galloyl-d-glucopyranose from paeonia lactiflora roots as a ptp1b inhibitor. | the inhibition of protein tyrosine phosphatase 1b (ptp1b) is of substantial interest for the treatment of type-2 diabetes mellitus. using an in vitro enzyme assay with human recombinant ptp1b 1,2,3,4,6-penta-o-galloyl-d-glucopyranose was isolated from the roots of paeonia lactiflora as an inhibitor of ptp1b, with an ic(50) value of 4.8 μm. additionally, 1 was shown to act as an insulin sensitizer in human hepatoma cells (hcc-1.2) at a concentration of 10 μm. thus, a potential new mechanism of ac ... | 2010 | 20806783 |
| platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from paeonia lactiflora and paeonia suffruticosa. | the roots of two paeoniaceae family members have long been used as traditional medicines in korea, china, and japan. dry roots of paeonia lactiflora and dry root bark of p. suffruticosa are used under the traditional names of paeoniae radix and moutan cortex, respectively. both paeoniae radix and moutan cortex have been used as remedies for cardiovascular diseases, for improving blood circulation, or for other uses. it was postulated that both plants may contain common active constituents that c ... | 2010 | 20824965 |