| the anorexient activity of kalio-kund (dioscorea bulbifera linn.), methylphenidate and cocaine in rats: a preliminary study. | | 1969 | 5823172 |
| [preliminary studies on the toxicity of dioscorea bulbifera on the liver and kidney]. | | 1983 | 6226428 |
| [studies on liver-toxicity in rhigoma of dioscorea bulbifera]. | to explore the liver-toxic fraction in rhigoma of dioscorea bulbifera. | 2003 | 15139116 |
| bafoudiosbulbins a, and b, two anti-salmonellal clerodane diterpenoids from dioscorea bulbifera l. var sativa. | two clerodane diterpenoids, bafoudiosbulbins a 1, and b 2, together with five known compounds: tetracosanoic acid, 1-(tetracosanoyl)-glycerol, trans-tetracosanylferulate, beta-sitosterol and 3-o-beta-d-glucopyranosyl-beta-sitosterol were isolated from the tubers of dioscorea bulbifera l. var sativa. their structures were established by spectroscopic methods (1d and 2d-nmr, ms) and x-ray crystallographic diffraction analysis of compound 1. the ch2cl2-soluble portion of the crude extract and the t ... | 2006 | 16876211 |
| a potential plasmid-curing agent, 8-epidiosbulbin e acetate, from dioscorea bulbifera l. against multidrug-resistant bacteria. | bioassay-guided fractionation of an aqueous methanolic extract of dioscorea bulbifera l. bulbs was performed using organic solvents. a novel plasmid-curing compound was identified as 8-epidiosbulbin e acetate (eea) (norditerpene) on the basis of modern spectroscopic analysis and x-ray crystallography. eea exhibited broad-spectrum plasmid-curing activity against multidrug-resistant (mdr) bacteria, including vancomycin-resistant enterococci. eea cured antibiotic resistance plasmids (r-plasmids) fr ... | 2008 | 18718743 |
| study of the hepatotoxicity induced by dioscorea bulbifera l. rhizome in mice. | dioscorea bulbifera l. is a medicinal plant. the present study was undertaken to investigate the hepatotoxicity induced by d. bulbifera in mice. through the acute toxicity of various extracts including the etoac fraction (ef) and the non-etoac fraction (non-ef) from ethanol, and the ethanol itself, we found that the ef contains the toxic ingredients of d. bulbifera rhizome. on this basis, to study the hepatotoxicity induced by the toxic ingredients, mice were treated with 0.5% sodium carboxymeth ... | 2010 | 20448345 |
| synthesis of silver nanoparticles using dioscorea bulbifera tuber extract and evaluation of its synergistic potential in combination with antimicrobial agents. | development of an environmentally benign process for the synthesis of silver nanomaterials is an important aspect of current nanotechnology research. among the 600 species of the genus dioscorea, dioscorea bulbifera has profound therapeutic applications due to its unique phytochemistry. in this paper, we report on the rapid synthesis of silver nanoparticles by reduction of aqueous ag(+) ions using d. bulbifera tuber extract. | 2012 | 22334779 |
| dioscin's antiviral effect in vitro. | dioscin is chemical compound obtained from an extract from a medical plant, air potato that is a yam species. its potential antiviral properties were analyzed in this study. in this study, dioscin's antiviral effects were tested against several viruses including adenovirus, vesicular stomatitis virus (vsv) and hepatitis b virus (hbv). by time-of-addition assay, dioscin not only blocked the initial stage of adenovirus infection, but also affected the host cell's response for viral infection. in a ... | 2013 | 23238077 |
| antibacterial activities of the extracts, fractions and compounds from dioscorea bulbifera. | dioscorea bulbifera is an african medicinal plant used to treat microbial infections. in the present study, the methanol extract, fractions (dbb1 and dbb2) and six compounds isolated from the bulbils of d. bulbifera, namely bafoudiosbulbins a (1), b (2), c (3), f (4), g (5) and 2,7-dihydroxy-4-methoxyphenanthrene (6), were tested for their antimicrobial activities against mycobacteria and gram-negative bacteria involving multidrug resistant (mdr) phenotypes expressing active efflux pumps. | 2012 | 23176193 |
| chemopreventive effect of a mixture of chinese herbs (antitumor b) on chemically induced oral carcinogenesis. | in this study, we evaluated chemopreventive efficacy of antitumor b, a chinese herbal mixture of six plants (sophora tonkinensis, polygonum bistorta, prunella vulgaris, sonchus arvensis l., dictamnus dasycarpus, and dioscorea bulbifera) on the development of 4-nitroquinoline-1-oxide (4nqo) induced oral squamous cell carcinomas in a/j mice. antitumor b, delivered through diet, inhibited 4nqo-induced oral cancer development by 59.19%. the reduction of cell proliferation appears to be associated wi ... | 2011 | 22086836 |
| antitumor activity of dioscorea bulbifera l. rhizome in vivo. | antitumor activities of water extract (fraction a), ethanol extract (fraction b), ethyl acetate extract (fraction c), non-ethyl acetate extract (fraction d) and compound diosbulbin b isolated from dioscorea bulbifera l. (db) were investigated in vivo in this present study. the results showed that fractions b and c both decreased tumor weight in s180 and h22 tumor cells bearing mice, while fractions a and d had no such effect. furthermore, fraction c altered the weight of spleen and thymus, and t ... | 2011 | 22178682 |
| protective role of air potato (dioscorea bulbifera) of yam family in myocardial ischemic reperfusion injury. | hydroalcoholic extract of dioscorea bulbifera (db), a yam variety called air potato, was tested for its protective effect on myocardial ischemic/reperfusion (i/r) injury in rats due to apoptosis and necrosis. myocardial i/r injury was induced by 30 min ischemia followed by 2 h reperfusion by perfusing isolated rat hearts with krebs henseilet bicarbonate (khb) buffer in a langendorff set up. pretreatment of db (150 mg kg(-1) body weight) for 30 days significantly reduced myocardial infarct size a ... | 2010 | 21776477 |
| [evaluation on hepatotoxicity caused by dioscorea bulbifera based on analysis of bile acids]. | metabolic profile of bile acids was used to evaluate hepatotoxicity of mice caused by ethanol extraction of dioscorea bulbifera l. (ethanol extraction, et) and diosbulbin b (db), separately. ultra-performance liquid chromatography coupled with quadrupole mass spectrometry (uplc-ms) was applied to determine the contents of all kinds of endogenous bile acids including free bile acids, taurine conjugates and glycine conjugates. obvious liver injuries could be observed in mice after administrated wi ... | 2011 | 21465807 |
| the furano norclerodane diterpenoid disobulbin-d induces apoptosis in normal human liver l-02 cells. | disobulbin-d (dbd), a hepatotoxic furano norclerodane diterpenoid, was isolated by bio-guided fractionation from the rhizome of dioscorea bulbifera l. in working toward elucidating the cellular and molecular mechanisms of dbd toxicity, we treated normal human liver cell line l-02 cells with dbd in vitro and evaluated its toxicity in terms of cell viability, morphologic changes, induction of apoptosis/necrosis, and caspase 3 activity. the viability of l-02 cells was inhibited by dbd in a concentr ... | 2011 | 21211949 |
| steroidal saponins from the rhizomes of dioscorea bulbifera and their cytotoxic activity. | two new steroidal saponins, diosbulbisides d ( 1) and e ( 2), along with five known saponins ( 3- 7) were isolated from the rhizomes of dioscorea bulbifera l. their structures were elucidated on the basis of spectral data. compounds 6 and 7, two 3- o-trisaccharides of diosgenin spirostanes, showed moderate cytotoxic activity against human hepatocellular carcinoma cells, with ic (50) values of 3.89 µm and 7.47 µm on smmc7721, and 10.87 µm and 19.10 µm on bel-7402 cell lines, respectively. | 2010 | 21165820 |
| gender-related difference in liver injury induced by dioscorea bulbifera l. rhizome in mice. | the present study was undertaken to investigate the gender-related liver injury induced by dioscorea bulbifera l. (db), a traditional medicinal plant, in mice, and further explored its hepatotoxic chemical compound. serum and liver tissue samples were collected at 0, 4, 8, 12 h, after mice were administrated orally with 640 mg/kg ethyl acetate extracts (ef) isolated from db. after treatments, serum alanine transaminase (alt) and aspartate transaminase (ast) activities were both significantly ele ... | 2010 | 21075805 |
| analgesic and anti-inflammatory properties of extracts from the bulbils of dioscorea bulbifera l. var sativa (dioscoreaceae) in mice and rats. | the aqueous and methanol extracts from the dry bulbils of dioscorea bulbifera l. var sativa (dioscoreaceae)-evaluated orally at the doses of 300 and 600 mg/kg against pain induced by acetic acid, formalin, pressure and against inflammation induced by carrageenan, histamine, serotonin and formalin in mice and rats, showed a dose dependant inhibition of pain and inflammation with a maximum effect of 56.38%, 73.06% and 42.79% produced by the aqueous extract, respectively on pain induced by acetic a ... | 2010 | 20953397 |
| flavonoid rich fraction of dioscorea bulbifera linn. (yam) enhances mitochondrial enzymes and antioxidant status and thereby protects heart from isoproterenol induced myocardial infarction. | with recent advances in nutrition sciences, natural products and health-promoting foods have received extensive attention from both health professionals and the common population. the flavonoid rich fraction (frf) of dioscorea bulbifera linn. has a strong free radical scavenging activity. frf (150 mg/kg) when intervened for a period of 35 days prior to isoproterenol (iso) challenge to rats maintained the creatine kinase - mb (ck-mb) activity in serum without elevation. alterations in the antioxi ... | 2010 | 20874686 |
| antinociceptive activities of the methanol extract of the bulbs of dioscorea bulbifera l. var sativa in mice is dependent of no-cgmp-atp-sensitive-k(+) channel activation. | dioscorea bulbifera var sativa is a medicinal plant commonly used in cameroonian traditional medicine to treat pain and inflammation. | 2010 | 20152893 |
| steroidal sapogenins and glycosides from the rhizomes of dioscorea bulbifera. | four new steroidal sapogenins (1-4), named diosbulbisins a-d, two new spirostane glycosides, diosbulbisides a (5) and b (6), one new cholestane glycoside, diosbulbiside c (7), and the known compounds 8-10 were isolated from rhizomes of dioscorea bulbifera. their structures were elucidated by 1d and 2d nmr techniques, hrftms, and chemical methods. the unusual furospirostanol sapogenin skeletons, as found in compounds 3 and 4, are reported in the family dioscoreaceae for the first time. cytotoxici ... | 2009 | 19842682 |
| [anticancer effects of various fractions extracted from dioscorea bulbifera on mice bearing hepa]. | to investigate the anti-cancer activities and the possible mechanism of chinese herb dioscrea bulbifera. | 2004 | 15706925 |
| antitumor-promoting constituents from dioscorea bulbifera l. in jb6 mouse epidermal cells. | an antitumor-promoting effect was found in the extracts/ingredients of a plant used as a traditional medicine in mainland china, using the neoplastic transformation assay of mouse epidermal jb6 cell lines. the ethyl acetate soluble fraction of 75% ethanol extract of the rhizomes of dioscorea bulbifera l. showed an inhibitory effect against the tumor promotion of jb6 (cl 22 and cl 41) cells induced by a promoter, 12-o-tetradecanoylphorbol-13-acetate (tpa). further investigation on the constituent ... | 2002 | 12230129 |
| rapid isolation of promoter sequences by tail-pcr: the 5'-flanking regions of pal and pgi genes from yams (dioscorea). | using a modified tail-pcr technique, the 5'-flanking regions of the phenylalanine ammonia lyase (pal) genes of a yam species, dioscorea bulbifera, and the phosphoglucose isomerase (pgi) gene of d. tokoro were successfully isolated. two novel modifications of the tail-pcr procedure introduced here, namely (1) the use of a battery of random 10-mers (rapd primers) as short arbitrary primers, and (2) the use of a total of five nested, gene-specific primers, allow the rapid isolation of the 5'-flanki ... | 2000 | 10821191 |
| selective and sensitive platform for function-based screening of potentially harmful furans. | many furan-containing compounds have been reported to be toxic and/or carcinogenic. furanoids have been found in a wide range of fruits, herbs, foods, and beverages. the risks for intake of toxic furans have been rising, due to the rapid growth of globe-wide consumption of natural products. the objective of the study was to develop an analytical platform to screen cis-enediones (cis-enedials or γ-ketoenals) resulting from metabolic activation of potentially harmful furans. 2,5-dimethylfuran (dmf ... | 2014 | 25279953 |
| steroidal saponin diosgenin from dioscorea bulbifera protects cardiac cells from hypoxia-reoxygenation injury through modulation of pro-survival and pro-death molecules. | diosgenin, a steroidal saponin from plants, exhibits many biological potentials. herein, the cardioprotective role of diosgenin is studied. | 2016 | 27041852 |
| genetic diversity among air yam (dioscorea bulbifera) varieties based on single sequence repeat markers. | dioscorea is the largest genus in the dioscoreaceae family, and includes a number of economically important species including the air yam, d. bulbifera l. this study aimed to develop new single sequence repeat primers and characterize the genetic diversity of local varieties that originated in several municipalities of brazil. we developed an enriched genomic library for d. bulbifera resulting in seven primers, six of which were polymorphic, and added four polymorphic loci developed for other di ... | 2016 | 27323077 |
| the altered liver microrna profile in hepatotoxicity induced by rhizome dioscorea bulbifera in mice. | microrna (mirna) has been reported to play important roles in regulating drug-induced liver injury. ethyl acetate extract isolated from rhizoma dioscoreae bulbifera (ef) has been reported to induce hepatotoxicity in our previous studies. this study aims to observe the altered liver mirna profile and its related signalling pathway involved in ef-induced hepatotoxicity. serum alanine/aspartate aminotransferase assay showed that ef (450 mg/kg)-induced hepatotoxicity in mice. results of mirna chip a ... | 2016 | 27609015 |
| exploration in the cascade working mechanisms of liver injury induced by total saponins extracted from rhizoma dioscorea bulbifera. | rhizoma dioscorea bulbifera, the tuber of dioscorea bulbifera l., has been used to treat various diseases. however, the clinical application has been limited for its hepatotoxicity. in this study, we explored the cascade working mechanisms of time-dependent hepatotoxicity induced by total saponins extracted from rhizoma dioscorea bulbifera (tsrd). animals were orally administered with tsrd for indicated time period. the adverse effects were determined by histopathology and biochemistry. similar ... | 2016 | 27544548 |
| ferulic acid prevents liver injury induced by diosbulbin b and its mechanism. | the rhizome of dioscorea bulbifera linn, traditionally used to treat thyroid disease and cancer in china, is reported to induce serious liver injury during clinical practice. diosbulbin b (db), a diterpene lactone, has been found to be the main toxic compound in d. bulbifera. the present study aims to investigate the protection of ferulic acid (fa) against db-induced acute liver injury and its engaged mechanism. mice were orally administered fa (20, 40, 80 mg/kg) once daily for 6 consecutive day ... | 2016 | 27773891 |
| lysine- and cysteine-based protein adductions derived from toxic metabolites of 8-epidiosbulbin e acetate. | furanoid 8-epidiosbulbin e acetate (eea) is a major constituent of herbal medicine dioscorea bulbifera l. (db), a traditional herbal medicine widely used in asian nations. our early studies demonstrated that administration of eea caused acute hepatotoxicity in mice and the observed toxicity required p450-mediated metabolic activation. protein modification by reactive metabolites of eea has been suggested to be an important mechanism of eea-induced hepatotoxicity. the objectives of the present st ... | 2016 | 27816466 |
| the role of ntcp, oatp2, bsep and mrp2 in liver injury induced by dioscorea bulbifera l. and diosbulbin b in mice. | dioscorea bulbifera l. (db) is a traditional chinese herb used in thyroid disease and cancer. however, the clinical use of db remains a challenge due to its hepatotoxicity, which is caused, in part, by the presence of diosbulbin b (diob), a toxin commonly found in db extracts. as abnormal expression of hepatobiliary transporters plays an important role in drug-induced liver injury, we assessed the hepatotoxicity induced by db and diob, and explored their impacts on hepatobiliary transporter expr ... | 2017 | 28262508 |
| a single molecular marker to distinguish between species of dioscorea. | yams are species of the genus dioscorea (family dioscoreaceae), which consists of approximately 630 species. the majority of the world production of yams occurs in africa with 58.8 million t annually, but they are also produced in the americas and asia. the saponins in yams have been reported to possess various properties to improve health. the tuber and aerial parts of various species often share morphological similarities, which can cause problems in the proper identification of sample materia ... | 2017 | 28092170 |
| plants used for treatment of dysentery and diarrhoea by the bhoxa community of district dehradun, uttarakhand, india. | dysentery and diarrhoea are major causes of morbidity and mortality in rural communities of developing world. the bhoxa community is an important primitive indigenous community of uttarakhand, india. in this paper we have tried to scientifically enumerate ethnomedicinal plants and herbal preparations used by bhoxa community to treat dysentery and diarrhoea, and discuss their antidiarrhoeal properties in the light of previous ethnomedicinal, pharmacological, microbiological and phytochemical stud ... | 2013 | 24432368 |
| plants used for treatment of dysentery and diarrhoea by the bhoxa community of district dehradun, uttarakhand, india. | dysentery and diarrhoea are major causes of morbidity and mortality in rural communities of developing world. the bhoxa community is an important primitive indigenous community of uttarakhand, india. in this paper we have tried to scientifically enumerate ethnomedicinal plants and herbal preparations used by bhoxa community to treat dysentery and diarrhoea, and discuss their antidiarrhoeal properties in the light of previous ethnomedicinal, pharmacological, microbiological and phytochemical stud ... | 2013 | 24513640 |
| antimicrobial, antioxidant activities and total phenolic content of thai medicinal plants used to treat hiv patients. | opportunistic infections in aids patients is the leading cause of death in among them. hiv infection was reported as causes of increasing oxidative stress which may lead to progress of many syndrome. thus medicinal plants as demonstrated antimicrobial and antioxidant activities would be therapeutic values to treat opportunistic infections of aids patients. | 2012 | 23964459 |
| role of metabolic activation in 8-epidiosbulbin e acetate-induced liver injury: mechanism of action of the hepatotoxic furanoid. | 8-epidiosbulbin e acetate (eea), a furanoid, was unexpectedly found to be the most abundant diterpenoid lactone in certain varieties of dioscorea bulbifera l. (db), a traditional herbal medicine widely used in asian nations. this herb has been reported to cause liver injury in humans and experimental animals. the occurrence of eea in db was dependent on its commercial source. the present study shows that eea exhibits time- and dose-dependent liver injury in mice. pretreatment with ketoconazole p ... | 2016 | 26886724 |
| anti-hiv-1 integrase compounds from dioscorea bulbifera and molecular docking study. | dioscorea bulbifera l. (dioscoreaceae) has been used in a traditional thai longevity medicine preparation. isolation of inhibitors from natural products is a potential source for continuous development of new hiv-1 integrase (in) inhibitors. | 2016 | 26864337 |
| dioscorea bulbifera polysaccharide and cyclophosphamide combination enhances anti-cervical cancer effect and attenuates immunosuppression and oxidative stress in mice. | cyclophosphamide (ctx) is commonly used in cancer chemotherapy, which causes immunosuppression and tissue oxidative stress at high doses. as potential protective agents, some polysaccharides were shown to have anti-tumor, anti-inflammatory and/or anti-oxidant properties. this study explored potential effects of oral treatment of dioscorea bulbifera polysaccharides (dblp at 100 or 150 mg/kg) in u14 cervical tumor-bearing mice treated with ctx (25 mg/kg). while ctx suppressed tumor growth (65.4% i ... | 2016 | 26753518 |
| novel platinum-palladium bimetallic nanoparticles synthesized by dioscorea bulbifera: anticancer and antioxidant activities. | medicinal plants serve as rich sources of diverse bioactive phytochemicals that might even take part in bioreduction and stabilization of phytogenic nanoparticles with immense therapeutic properties. herein, we report for the first time the rapid efficient synthesis of novel platinum-palladium bimetallic nanoparticles (pt-pdnps) along with individual platinum (ptnps) and palladium (pdnps) nanoparticles using a medicinal plant, dioscorea bulbifera tuber extract (dbte). high-resolution transmissio ... | 2015 | 26719690 |
| diosgenin functionalized iron oxide nanoparticles as novel nanomaterial against breast cancer. | iron oxide nanoparticles (ionps) have gained immense importance recently as drug nanocarriers due to easy multifunctionalization, simultaneous targeting, imaging and cancer hyperthermia. herein, we report a novel nanomedicine comprising of ionps core functionalized with a potent anticancer bioactive principle, diosgenin from medicinal plant dioscorea bulbifera via citric acid linker molecule. ionps were synthesized by reverse co-precipitation and characterized using field emission scanning elect ... | 2015 | 26682367 |
| in vitro and in vivo studies of the metabolic activation of 8-epidiosbulbin e acetate. | furanoid 8-epidiosbulbin e acetate (eea) is a major constituent of herbal medicine dioscorea bulbifera l. (db), a traditional chinese medicine herb. our preliminary studies demonstrated that administration of eea caused acute hepatotoxicity in mice, and the observed toxicity required cytochromes p450-mediated metabolism. metabolic activation studies of eea were performed in vitro and in vivo. microsomal incubations of eea supplemented with n-acetyl lysine (nal) and glutathione (gsh) generated si ... | 2015 | 26286065 |
| quantitative analysis of heavy metals in medicinal plants collected from environmentally diverse locations in india for use in a novel phytopharmaceutical product. | it is important to monitor the quality of the phytopharmaceutical product as its therapeutic potential depends on standardized delivery of active ingredients present in the botanical source. minimal presence of toxic impurities like heavy metals (hms) is warranted to ensure product safety and prevent hazardous health impacts. in the present study, conducted as part of the development of a novel phytopharmaceutical product, the chemical profile of 13 heavy metals (fe, cu, mn, zn, ni, co, mo, v, c ... | 2015 | 26223217 |
| metabolic activation of furan moiety makes diosbulbin b hepatotoxic. | diosbulbin b (diob), a furanoid, is a major constituent of herbal medicine dioscorea bulbifera l. exposure to diob caused liver injury in humans and experimental animals. the mechanisms of diob-induced hepatotoxicities remain unknown. the present study demonstrated that diob induced hepatotoxicities in a time- and dose-dependent manner in mice. h&e stained histopathologic image showed the occurrence of necrosis in the liver obtained from the mice treated with diob at dose of 200 mg/kg. pretreatm ... | 2016 | 25851819 |
| serum and liver lipids distributions in streptozotocin induced diabetic rat treated with diet containing yam (dioscorea bulbifera) flour. | liver disease as a major cause of mortality in patients with diabetes mellitus. there is a interest to investigate the hypolipidemic properties of yam. the goal was assess the role of brazilian yam (dioscorea bulbifera) on serum and hepatic levels of triglycerides and cholesterol, in female diabetic rats. | 2015 | 25795953 |
| antidiabetic activity of gnidia glauca and dioscorea bulbifera: potent amylase and glucosidase inhibitors. | diabetes is a metabolic disorder affecting about 220 million people worldwide. one of the most critical complications of diabetes is post-prandial hyper-glycemia (pphg). glucosidase inhibitor and α-amylase inhibitors are class of compounds that help in managing pphg. low-cost herbal treatment is recommended due to their lesser side effect for treatment of diabetes. two plants with significant traditional therapeutic potential, namely, gnidia glauca and dioscorea bulbifera, were tested for their ... | 2012 | 21785651 |
| scutellarin protects against the liver injury induced by diosbulbin b in mice and its mechanism. | diosbulbin b (db) is the main hepatotoxic compound distributed in dioscorea bulbifera l., which is widely used for the treatment of cancer and thyroid disorders in asia. scutellarin (sc) is the main compound in medicinal herb scutellaria barbata d. don, which is usually combined with dioscorea bulbifera used for cancer therapy in clinic. | 2015 | 25701748 |
| protection of angelica sinensis (oliv) diels against hepatotoxicity induced by dioscorea bulbifera l. and its mechanism. | dioscorea bulbifera l., a traditionally used medicinal plant in china, is reported to induce hepatotoxicity. the present study is designed to investigate the protection of an ethanol extract of angelica sinensis (oliv) diels (ae) against an ethyl acetate fraction of d. bulbifera (ef)-induced liver injury and its engaged mechanism. high performance liquid chromatography (hplc) analysis showed that the amount of diosbulbin b in ef was 16.03% and ferulic acid in ae was 0.18%. ef (350 mg/kg) increas ... | 2014 | 25382441 |
| [preliminary study of dioscorea bulbifera plantlet microtuber in vitro induction]. | in order to provide a theoretical basis for the microtuber factory production and its germplasm resources preservation, in vitro induction of dioscorea bulbifera plantlet microtubers was studied. | 2014 | 25345120 |
| management of cognitive determinants in senile dementia of alzheimer's type: therapeutic potential of a novel polyherbal drug product. | the enigmatic etiology of neurodegenerative diseases poses a challenge for the development of novel and efficient drugs. the objective of the present study was to evaluate the efficacy of a polyherbal (test) formulation on cognitive functions, inflammatory markers and oxidative stress in healthy elderly as well as senile dementia of alzheimer's type (sdat) patients. | 2014 | 25316430 |
| comparative micromorphological study of wild and micropropagated dioscorea bulbifera linn. | to study the leaf epidermis of wild and micropropagated dioscorea bulbifera linn. (d. bulbifera) in order to document useful diagnostic features that may be employed for correct crude drug identification and to clear any taxonomic uncertainties in the micropropagated medicinal plant. | 2014 | 25182434 |
| metabolism of diosbulbin b in vitro and in vivo in rats: formation of reactive metabolites and human enzymes involved. | diosbulbin b (db), a major constituent of the furano-norditerpenes in dioscorea bulbifera linn, exhibits potential antineoplasmic activity and hepatotoxicity. the metabolism and reactive metabolites of db in vitro (with human and animal liver microsomes) and in vivo in rats were investigated. the human enzymes involved in db metabolism were identified. db was first catalyzed into reactive metabolites of 2-butene-1,4-dial derivatives dependent on nadph and then trapped by tris base or oxidized to ... | 2014 | 25053620 |
| two new furanoid norditerpenes from dioscorea bulbifera. | two new furanoid norditerpenes (1, 2) were isolated from the root tubers of dioscorea bulbifera l. their structures were established on the basis of extensive spectroscopic analysis. | 2009 | 19483348 |
| cytochrome p450-mediated metabolic activation of diosbulbin b. | diosbulbin b (diob), a furan-containing diterpenoid lactone, is the most abundant component of dioscorea bulbifera l. (db), a traditional chinese medicine herb. administration of purified diob or db extracts has been reported to cause liver injury in animals. the mechanisms of diob-induced hepatotoxicity remain unknown. the major objective of this study was to identify reactive metabolites of diob. a diob-derived cis-enedial was trapped by n-acetyl lysine (nal) and glutathione (gsh) or n-acetyl ... | 2014 | 25024403 |
| new norclerodane diterpenoids from the tubers of dioscorea bulbifera. | phytochemical investigations of the tubers of dioscorea bulbifera l. resulted in the isolation of nine norclerodane diterpenoids, including two new compounds, diosbulbins n (1) and p (3), a new naturally occurring compound, diosbulbin o (2), and six known ones, diosbulbins a-d, f and g (4-9). their structures were established by spectroscopic and chemical methods. the absolute stereochemistry of 1 was determined by a modified mosher's method, and the absolute configuration of 2 was determined by ... | 2014 | 24740003 |
| isolation and characterization of polymorphic microsatellite loci from aerial yam (dioscorea bulbifera l.). | dioscorea bulbifera l. is widely distributed in pantropical regions along the equator. the taxonomic treatment of this species is ambiguous due to its extreme polymorphic morphological characters. in order to provide tools to facilitate the study of genetic diversity, population structure, patterns of gene flow, and the mating system of this species, and to assess intraspecific variability and relationships in d. bulbifera, 14 novel polymorphic microsatellite loci were developed using the dual-s ... | 2014 | 24668625 |
| cytokines as potential biomarkers of liver toxicity induced by dioscorea bulbifera l. | the present study is designed to search for the serum cytokine biomarker for liver injury induced by dioscorea bulbifera l., which is a traditionally used herbal medicine in china. mice were orally given various doses of ethyl acetate extract (ef) isolated from d. bulbifera for 12 days. the activity of serum alanine/aspartate transaminases (alt/ast) was increased in ef (400 mg/kg)-treated mice. histological assessment further confirmed ef (400 mg/kg)-induced liver injury. results of a cytokine-a ... | 2014 | 24647110 |
| the intake of yam (dioscorea bulbifera linn) attenuated the hyperglycemia and the bone fragility in female diabetic rats. | diabetic patients have a higher risk to osteoporotic fractures. foods, such as yam, to oppose hyperglycemia, has been used to treatment of diabetes. | 2014 | 24528355 |
| phytochemical analysis and free radical scavenging activity of medicinal plants gnidia glauca and dioscorea bulbifera. | gnidia glauca and dioscorea bulbifera are traditional medicinal plants that can be considered as sources of natural antioxidants. herein we report the phytochemical analysis and free radical scavenging activity of their sequential extracts. phenolic and flavonoid content were determined. scavenging activity was checked against pulse radiolysis generated abts(•+) and oh radical, in addition to dpph, superoxide and hydroxyl radicals by biochemical methods followed by principal component analysis. ... | 2013 | 24367520 |
| antioxidant and sgc-7901 cell inhibition activities of rhizoma dioscoreae bulbiferae. ethanol extracts. | the objective of this research was to study the pharmacology of dioscorea bulbifera l. on antioxidant and anticancer activity. alcohol extracts of dioscorea bulbifera l. were made out by different concentration alcohol; they were tested by hydroxyl radical scavenging test, reducing capacity test and total antioxidant capacity test. in the anticancer test, mtt test was used to study the inhibition rate. the results told that 70% ethanol extracts could scavenge most dpph· at 2 mg/ml. the rate was ... | 2013 | 24311834 |
| [protection of grateloupia filicina polysaccharide against hepatotoxicity induced by dioscorea bulbifera l]. | the present study was designed to observe the protection of grateloupia filicina polysaccharide (gfp) against hepatotoxicity induced by dioscorea bulbifera l in mice and its underlying mechanism. gfp was intragastrically (ig) given to mice at various doses. after 6 days, the mice were treated with ethyl acetate extract of dioscorea bulbifera l (ef, ig). serum levels of alanine/aspartate aminotransferase (alt/ast), alkaline phosphatase (alp), total bilirubin (tb) were measured, and liver histolog ... | 2013 | 24187832 |
| diosbulbin b-induced liver injury in mice and its mechanism. | dioscorea bulbifera l., a commonly used medicinal plant in china, is reported to induce hepatotoxicity. the present study is undertaken to investigate the hepatotoxicity induced by diosbulbin b (db), a diterpene lactone isolated from d. bulbifera l., and to further explore its underlying mechanism. db was administered to mice at the doses of 0, 16, 32, and 64 mg/kg once daily for 12 consecutive days. liver injury induced by db was evidenced by the increased activity of serum alanine aminotransfe ... | 2014 | 24107456 |
| cytotoxicity of elaoephorbia drupifera and other cameroonian medicinal plants against drug sensitive and multidrug resistant cancer cells. | multidrug resistance (mdr) is a major hurdle for cancer treatment worldwide and accounts for chemotherapy failure in over 90% of patients with metastatic cancer. evidence of the cytotoxicity of cameroonian plants against cancer cell lines including mdr phenotypes is been intensively and progressively provided. the present work was therefore designed to evaluate the cytotoxicity of the methanol extracts of twenty-two cameroonian medicinal plants against sensitive and mdr cancer cell lines. | 2013 | 24088184 |
| steroidal saponins from the flowers of dioscorea bulbifera var. sativa. | eleven steroidal saponins, dioscoreanosides a-k, along with five known congeners, were isolated from the flowers of dioscorea bulbifera var. sativa. their structures were established by extensive nmr experiments in conjunction with mass spectrometry. the isolated compounds were tested for cytotoxicity against urinary bladder carcinoma cells (ecv-304 cells). our results revealed a moderate activity for spiroconazol a (15), pennogenin 3-o-α-l-rhamnopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→4)-[α-l-rh ... | 2013 | 23969106 |
| gender-related pharmacokinetics and absolute bioavailability of diosbulbin b in rats determined by ultra-performance liquid chromatography-tandem mass spectrometry. | diosbulbin b (db) is the main constituent of furano-norditerpenes in dioscorea bulbifera linn., which is widely distributed in china and was usually used as a remedy for sore throat, struma and tumor. owing to its potential antitumor activity, db has been considered as a promising candidate for drug development. | 2013 | 23954278 |
| comparative evaluation of fosinopril and herbal drug dioscorea bulbifera in patients of diabetic nephropathy. | worldwide, diabetic nephropathy is one of the leading causes of end-stage renal failure. this hospital-based single-center prospective open-label randomized case-control interventional study was performed to evaluate and compare the native drug dioscorea bulbifera with fosinopril in the management of diabetic nephropathy. patients with diabetic nephropathy with proteinuria >500 mg/day or albuminuria >300 mg/ day, s cr ≤2.5 mg/dl and hypertension controlled with a single drug were included into t ... | 2013 | 23816723 |
| glycosides from dioscorea bulbifera. | | 1997 | 9428100 |
| invasive plants as feedstock for biochar and bioenergy production. | in this work, the potential of invasive plant species as feedstock for value-added products (biochar and bioenergy) through pyrolysis was investigated. the product yield rates of two major invasive species in the us, brazilian pepper (bp) and air potato (ap), were compared to that of two traditional feedstock materials, water oak and energy cane. three pyrolysis temperatures (300, 450, and 600°c) and four feedstock masses (10, 15, 20, and 25 g) were tested for a total of 12 experimental conditio ... | 2013 | 23711882 |
| a panel of serum micrornas as specific biomarkers for diagnosis of compound- and herb-induced liver injury in rats. | drug-induced liver injury (dili) has been a public, economic and pharmaceutical issue for many years. enormous effort has been made for discovering and developing novel biomarkers for diagnosing and monitoring both clinical and preclinical dili at an early stage, though progress has been relatively slow. additionally, herb-induced liver injury is an emerging cause of liver disease because herbal medicines are increasingly being used worldwide. recently, circulating micrornas (mirnas) have shown ... | 2012 | 22624025 |
| phenolic compounds from the rhizomes of dioscorea bulbifera. | one new bibenzyl, 7, and one new diarylheptanone, diobulbinone a (18), together with sixteen known compounds, 1-6 and 8-17, have been isolated form the rhizomes of dioscorea bulbifera. their structures were elucidated by nmr and ms analyses. compound 7 showed high antioxidant capacity in frap assay and dpph radical-scavenging activity. | 2011 | 22083923 |
| intraspecific variation of chloroplast dna in dioscorea bulbifera l. | restriction fragment length polymorphism (rflp) analysis of chloroplast (ct) dnas from 15 accessions of dioscorea bulbifera collected from africa and asia was carried out using the southern hybridization technique. eight cloned ctdna fragments of d. bulbifera and d. opposita, which cover 80% of the total chloroplast genome, were used as the probes to detect variation in ctdna digested with nine restriction endonucleases. ten variable sites, located in the large and small single-copy regions, wer ... | 1991 | 24221310 |
| new clerodane diterpenoid from the bulbils of dioscorea bulbifera. | a new clerodane diterpenoid has been isolated from the acetone extract of bulbils of dioscorea bulbifera. the structure of compound 1 was established as 15,16-epoxy-6alpha-o-acety1-8beta-hydroxy- 9-nor-clero-13(16),14-diene-17,12;18,2-diolide on the basis of comprehensive spectroscopic techniques. | 2011 | 21922900 |
| tuberization of dioscorea bulbifera stem nodes in culture. | tuberization of dioscorea bulbifera expiants was induced in culture by media manipulation. this plant, commonly known as the air potato, produces aerial tubers in response to short day conditions in vivo. nodal stem segments harvested from vigorously growing vines in spring and early summer served as experimental material. nodal stem expiants of solarium tuberosum were used in one experiment to ascertain whether the response was similar in other tuberizing species. an increase in sucrose concent ... | 1984 | 23196089 |
| yellow pigments of dioscorea bulbifera. | | 2013 | 4840586 |
| bitter compounds in tubers of dioscorea bulbifera l. | | 2010 | 4840585 |
| review of the continental oriental species of lilioceris reitter (coleoptera, chrysomelidae, criocerinae) closely related to lilioceris impressa (f.). | criocerine leaf beetles found in nepal feeding on dioscorea bulbifera (l.), an invasive weed of asian origin, were identified as lilioceris cheni gressitt and kimoto based on a synopsis of the oriental lilioceris species and review of the lilioceris impressa species group. all the continental, oriental species included in the group are diagnosed and illustrated, and a key for their identification is provided. species status of lilioceris thibetana pic, 1916 is resurrected. the following new syno ... | 2011 | 21747681 |
| total phenolic contents and antioxidant capacities of selected chinese medicinal plants. | antioxidant capacities of 56 selected chinese medicinal plants were evaluated using the trolox equivalent antioxidant capacity (teac) and ferric reducing antioxidant power (frap) assays, and their total phenolic content was measured by the folin-ciocalteu method. the strong correlation between teac value and frap value suggested that the antioxidants in these plants possess free radical scavenging activity and oxidant reducing power, and the high positive correlation between antioxidant capaciti ... | 2010 | 20640157 |
| norclerodane diterpenoids from rhizomes of dioscorea bulbifera. | three norclerodane diterpenoids, diosbulbins k-m, and one analogous enolglycoside, diosbulbinoside g, together with four norclerodane diterpenoids, diosbulbins b, e, f and g, were isolated from rhizomes of dioscorea bulbifera. their structures were established by spectroscopic and chemical methods, including 1h and 13c nmr, noesy, hsqc, hmbc, and hrms analyses. the relative configurations of diosbulbins k and l, and diosbulbin f were confirmed by x-ray crystallographic diffraction analysis, and ... | 2010 | 20452632 |
| diosgenin from dioscorea bulbifera: novel hit for treatment of type ii diabetes mellitus with inhibitory activity against α-amylase and α-glucosidase. | diabetes mellitus is a multifactorial metabolic disease characterized by post-prandial hyperglycemia (pphg). α-amylase and α-glucosidase inhibitors aim to explore novel therapeutic agents. herein we report the promises of dioscorea bulbifera and its bioactive principle, diosgenin as novel α-amylase and α-glucosidase inhibitor. among petroleum ether, ethyl acetate, methanol and 70% ethanol (v/v) extracts of bulbs of d. bulbifera, ethyl acetate extract showed highest inhibition upto 72.06 ± 0.51% ... | 2014 | 25216353 |
| aboriginal uses and management of ethnobotanical species in deciduous forests of chhattisgarh state in india. | a study on the native uses of ethnobotanical species was carried out in the south surguja district of chhattisgarh state in india with the major objective of identifying different food and medicinal plant species and also to understand their ongoing management and conservation. through questionnaire and personal interviews, a total of 73 ethnobotanical species used by tribal and non-tribal communities were documented, of these 36 species were used in curing different types of diseases and 22 wer ... | 2009 | 19653889 |
| cryopreservation of asian dioscorea bulbifera l. and d. alata l. by vitrification: importance of plant growth regulators. | the aim of this study was to develop cryopreservation protocols for asian races of dioscorea bulbifera and d. alata with high survival and plant regeneration after cryopreservation. using a vitrification procedure, survival of shoot tips postcryopreservation of up to 89% in d. bulbifera and up to 82% in d. alata were recorded when excised shoot tips were pretreated overnight with 0.3 m sucrose in ms medium, followed by loading with 2 m glycerol plus 0.4 m sucrose for 20 min at 25 degrees c, expo ... | 2012 | 19448859 |
| tensioning the helix: a mechanism for force generation in twining plants. | twining plants use their helical stems to clasp supports and to generate a squeezing force, providing stability against gravity. to elucidate the mechanism that allows force generation, we measured the squeezing forces exerted by the twiner dioscorea bulbifera while following its growth using time-lapse photography. we show that the development of the squeezing force is accompanied by stiffening of the stem and the expansion of stipules at the leaf base. we use a simple thin rod model to show th ... | 2009 | 19386656 |
| cryopreservation of embryogenic callus of dioscorea bulbifera by vitrification. | cryopreservation of callus of dioscorea bulbifera by vitrification was optimized. calli of dioscorea bulbifera were pretreated in liquid murashige and skoog (ms) medium supplemented with 2 mg l(-1) kinetin (kt), 0.5 mg l(-1) naa, 0.5 mg l(-1) 2,4-d and 0.2 m sucrose for 5 d under continuous light (36 microm m(-2) s(-1)) at 25 + or - 1 degree c. the material was then loaded with 60 percent vitrification solution (pvs2) for 20 min at room temperature and dehydrated with 100 percent pvs2 for 30 min ... | 2009 | 19274313 |
| biotransformation of cholesterol to diosgenin by freely suspended and immobilised cells of dioscorea bulbifera l. | the cell suspension cultures, established from the friable callus which was risen from the nodal segments of dioscorea bulbifera l. in murashige-skoog (ms) medium supplemented with indole-3-butryic acid (20 mg l(-1)), was examined for cell growth in ms medium fed with cholesterol (50 mg l(-1) and 100 mg l(-1)) after 8, 10, 12, 14, 16, and 18 days of culture. the growth index of the cell suspension culture on the 8th day was 1.2 and gradually inclined to 1.9 on the 16th day and remained the same ... | 2013 | 18253882 |
| [extraction and anti-tumor activity study of polysaccharide in several traditional chinese medicine]. | polysaccharides in several traditional chinese medicine compounds of dioscorea bulbifera l, dioscorea bulbifera l and chinese angelica compounds (3: 2 by mass ratio), hedyotis diffusa willd and scutellrla barbata d. don compounds (3: 2 by mass ratio) were extracted by ultrasound and the content of polysaccharides were determined by the colorimetry. dioscorea bulbifera l and chinese angelica compounds contained the biggest polysaccharide, 16. 509%. all of these three kinds of polysaccharide had a ... | 2007 | 17571768 |
| genetic fidelity of in vitro regenerants, encapsulation of shoot tips and high diosgenin content in dioscorea bulbifera l., a potential alternative source of diosgenin. | dioscorea bulbifera l. containing the pharmaceutically important compound, diosgenin, was regenerated in vitro through nodal segments on supplemented murashige and skoog medium (ms). diosgenin was at 12 mg g(-1)dry wt in 12-week-old plantlets raised on ms with various growth hormones. random amplified polymorphic dna (rapd) analysis showed genetic fidelity of regenerants. encapsulation of shoot tips in 3% (w/v) calcium alginate for storage and germplasm exchange was achieved. | 2007 | 17318334 |
| purification, characterization and biological significance of mannose binding lectin from dioscorea bulbifera bulbils. | dioscorea bulbifera or air potato has been used as a folk remedy to treat cancer. a mannose binding lectin from bulbils of d. bulbifera was purified in a single step by affinity chromatography on mucin coupled sepharose 4b column, determined by its fine sugar specificity by glycan array analysis and studied for its clinical potential in cancer and hiv research. sds-page showed that lectin is a monomer of mr 24kda. dbl agglutinated only rabbit erythrocytes and was inhibited by mucin, asialomucin, ... | 2017 | 28472687 |
| abiotic metal stress enhances diosgenin yield in dioscorea bulbifera l. cultures. | lower concentrations of cuso(4) (25-75 microm) in the ms medium supplemented with 0.1 mg l(-1) iaa+5.0 mg l(-1) kn+500 mg l(-1) ch+10 mg l(-1) cyst hyd enhanced the growth of regenerants of dioscorea bulbifera l. cuso(4) (75 microm) induced an appreciable diosgenin yield in the regenerants compared to those obtained on media without cu. the presence of cu thus seems to stimulate diosgenin production. the regenerants also differentiated bulbils on lower concentrations of cu. at cuso(4) (100 micro ... | 2005 | 15809888 |
| [characterisation of dioscorea bulbifera native starch]. | a non conventional source of starch, bulbs of dioscorea bulbifera, was evaluated. giving a yield of 28.48 g/100 g on dry weight, chemical composition, physical, physico-chemical and morphological characteristics were assessed, as well as its rheological properties. chemical analysis showed a amylose content of 29.37%. micrographies showed that most of the starch granules were of irregular shape, similar to a pyramid with rounded vertices, and a smaller number were elongated with smooth surface. ... | 2004 | 15586695 |
| in vitro micropropagation, differentiation of aerial bulbils and tubers and diosgenin content in dioscorea bulbifera. | dioscorea bulbifera could be micropropagated through nodal segments and bulbils. the best medium for regeneration and bulbil differentiation was ms + 0.5 microm iaa (indole-3-acetic acid) + 20.0 microm kn (kinetin) + 500 mg/l ch (casein hydrolysate) + activated charcoal (20 %). diosgenin content was maximum in regenerants grown on ms + 5.0 microm iaa + 20.0 microm kn + 500 mg/l ch. t.s of bulbils could also be used for direct plantlet differentiation as well as bulbil differentiation on ms + 10. ... | 2003 | 14531034 |
| [experimental pathological study of subacute intoxication by dioscorea bulbifera l]. | to study the pathological change and the toxic mechanism of dioscorea bulbifera l in mice. | 2003 | 12905576 |
| genetic stability assessment of plants regenerated from cryopreserved embryogenic tissues of dioscorea bulbifera l. using rapd, biochemical and morphological analysis. | embryogenic tissues of dioscorea bulbifera were cryopreserved using the encapsulation-dehydration technique. genetic stability of plants regenerated from cryopreserved embryogenic tissues was assessed using molecular, biochemical and morphological analysis. the random amplified polymorphic dna (rapd) analysis of 60 cryopreserved-derived and 20 in vitro grown (control) plantlets showed that 10 primers produced 62 clear reproducible dna fragment profiles. the amplification products were monomorphi ... | 2013 | 12819828 |
| [flavonoids and anthraquinone from dioscorea bulbifera l]. | to study the chemical constituents of dioscorea bulbifera. | 2000 | 12212098 |
| [evaluation of the possible technological uses of some dioscoreas tubers: name congo (dioscorea bulbifera) and mapuey (dioscorea trifida)]. | a comparison between the chemical composition and physical characteristics of ñame congo (dioscorea bulbifera) and mapuey (dioscorea trifida) white and purple varieties, was made. the tubers were evaluated for their physical attributes (morphology, size and weight). the chemical analysis was done according to aoac methods (1990) and the pasting properties of the flours were evaluated using the brabender viscoamilograph. the mapuey tubers have an elongated shape, with one end wider while ñame con ... | 2000 | 11347300 |
| genomic variation and relationships in aerial yam (dioscorea bulbifera l.) detected by random amplified polymorphic dna. | random amplified polymorphic dna (rapd) markers were used to assess intraspecific variability and relationships in aerial yam (dioscorea bulbifera l.). a total of 23 accessions from different geographic locations in africa, asia, and polynesia were analyzed by 10 arbitrarily chosen gc-rich decamer primers. using cesium chloride purified genomic template dna, highly reproducible polymorphic fingerprints were generated by all 10 primers, resulting in a total of 375 informative characters. only eig ... | 1996 | 18469875 |
| [cará-de-rama (dioscorea bulbifera, l) fried processing]. | the present study examined the influence of density of the aerial bulbs in the variables: fat absorption, fry time and yield of the cara-de-rama chips and french fries, as well as organoleptic analysis of fried products. the results showed that there was no differences between the bulbs densities, in the variables examined, except for the moisture of cara-de-rama chips. in the organoleptical analysis, the samples did not show significant differences in relation to similar potato products. | 1995 | 8729264 |
| diosbulbin-b from the leaves and stems of dioscorea bulbifera: 1h-1h and 13c-1h cosy nmr studies. | | 1993 | 17230373 |
| physical map of chloroplast dna of aerial yam, dioscorea bulbifera l. | a physical map of chloroplast dna (ctdna) of aerial yam, dioscorea bulbifera l. was constructed using three restriction endonucleases, psti, sali, and smai. in addition, a clone bank of the bamhi-digested fragments were generated, and the locations of most bamhi fragments on the map were also determined. the ctdna of d. bulbifera was found to be a circular molecule with a total size of ca. 152 kb involving two inverted repeats of ca. 25.5 kb, and small and large single copy regions of ca. 18.5 a ... | 1989 | 24227022 |
| characterizing genotypic variation in biochemical composition, anti-nutritional and mineral bioavailability of some nigerian yam (dioscorea spp.) land races. | the aim of this study was to characterize 43 genotypes from five yam species [dioscorea rotundata (poir), dioscorea alata (linn), dioscorea bulbifera (linn), dioscorea cayenensis (lam) and dioscorea dumetorum (kunith) pax] which are major land races in nigeria in terms of their chemical composition, nutritional, anti-nutritional and mineral bioavailability. findings showed that there was genotypic variation in terms of chemical composition, mineral profile and bioavailability of the minerals amo ... | 2018 | 29358812 |
| discovery of hepatotoxic equivalent combinatorial markers from dioscorea bulbifera tuber by fingerprint-toxicity relationship modeling. | due to extremely chemical complexity, identification of potential toxicity-related constituents from an herbal medicine (hm) still remains challenging. traditional toxicity-guided separation procedure suffers from time- and labor-consumption and neglects the additive effect of multi-components. in this study, we proposed a screening strategy called "hepatotoxic equivalent combinatorial markers (hecms)" for a hepatotoxic hm, dioscorea bulbifera tuber (dbt). firstly, the chemical constituents in d ... | 2018 | 29323207 |
| ethnopharmacological studies of indigenous plants in kel village, neelum valley, azad kashmir, pakistan. | this explorative study was undertaken for the first time in kel village located in the upper neelum valley, azad kashmir, pakistan. the purpose was to document the indigenous knowledge of the native people used in the preparation of herbal medicines. | 2017 | 29191238 |