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serological and biochemical relationships between the alleged avirulent variant of corynebacterium kutscheri and streptococci of group n.morphological, biochemical and serological observations suggested that no close relationship existed between c. kutscheri and its alleged avirulent variant isolated from mice at the rockefeller university. however, both capillary and double diffusion precipitin reactions showed the alleged variant to be a streptococcus of group n, indistinguishable from that previously isolated from rockefeller university mice.1978418113
studies on the host phage systems of corynebacterium murium species. the phage test in the etiologic diagnosis of corynebacterium infectons in mice. 19761008693
stability of pathogenic bacteria from laboratory animals in various transport media.the stability of pathogenic bacteria from laboratory animals was investigated in various transport media at different temperatures. bordetella bronchiseptica and salmonella typhimurium survived for 8 days in phosphate-buffered saline (pbs, ph 7.0) at 37, 24, 4 and -20 degrees c; brucella canis at 24, 4 and -20 degrees c; corynebacterium kutscheri at 4 and -20 degrees c; and pseudomonas aeruginosa at all but -20 degrees c. a marked decrease in numbers of pasteurella multocida and past. pneumotrop ...19911921320
[selective medium for corynebacterium kutscheri and localization of the organism in mice and rats].a new selective medium for isolation of corynebacterium kutscheri (ck) from animals suffering subclinical infection was made by adding furazolidone, nalidixic acid and corimycin to the heart infusion agar base, this being named fnc agar. the fnc agar inhibited the growth of gram-negative rods, pseudomonas aeruginosa, proteus sp. and gram-positive cocci but did not affect the growth of ck. when this medium was used to isolate ck from the oral cavity and cecal contents of mice and rats, two of 6 c ...19902242765
experimental corynebacterium kutscheri infection in rats: bacteriology and serology.in a preliminary study, hydrocortisone-treated rats developed pseudotuberculosis when challenged with 6.2 x 10(5) to 3.1 x 10(7) colony forming units of corynebacterium kutscheri by intranasal, intragastric, or subcutaneous inoculation. oronasal exposure was selected as a likely natural route to further study inapparent infection. in study 1, 50 rats received 1.2 x 10(5) colony forming units and various tissues were cultured at intervals to 12 weeks post-inoculation. at each interval, c. kutsche ...19853999695
serological surveys of corynebacterium kutscheri infection in mice and rats.serological surveys of mice and rats naturally infected with corynebacterium kutscheri were performed by examining serum samples collected from breeder and laboratory colonies between 1981 and 1983. among 756 mice from 73 conventional colonies, only 4 animals (0.5%) from 3 colonies (4.1%) developed c. kutscheri antibody of 1:40 to 1:2, 560 titers. three of them suffered from abscess caused by the organism. regarding a titer of 1:40 or higher as reliably positive, 87 (13.0%) of 669 conventional r ...19863803435
corynebacterium kutscheri septic arthritis. 19892765007
different species of corynebacteria in human investigations in cairo.in investigations undertaken in cairo of ocular smears the following corynebacteria were isolated: corynebacterium a4, corynebacterium a5, corynebacterium bovis, corynebacterium aquaticum, corynebacterium diphtheriae, corynebacterium equi, corynebacterium f2, corynebacterium kutscheri, corynebacterium minutissimi, corynebacterium renale, corynebacterium xerosis, corynebacterium group i, corynebacterium spec. (at present not classified). in this study the hitherto isolated species and possible hu ...19892689286
nonspecific stimulation of host defense by corynebacterium kutscheri. iii. enhanced cytokine induction by the active moiety of c. kutscheri.the present study was carried out to ascertain whether the active component of corynebacterium kutscheri (ck-m) could stimulate host cells of mice to produce several cytokines. ck-m stimulated thioglycollate-induced peritoneal macrophages to produce interleukin 1 (il-1) and tumor necrosis factor alpha (tnf-alpha) at concentrations of 1-100 ng/ml, and it also induced il-2 and interferon-gamma (ifn-gamma) as well as il-6 production by splenocytes. maximum production of each cytokine induced by ck- ...19921611281
chorioamnionitis and funisitis due to corynebacterium kutscheri.when isolated from the female genital tract, diphtheroids are usually regarded as commensal organisms. corynebacterium kutscheri however is a pathogen in laboratory rodents. we report a case in which c. kutscheri was isolated as a pure culture from the umbilical cord and from other surface sites in an infant. histological examination of the cord and membranes demonstrated the organisms within these fetal tissues. the organisms evoked a fetal cellular response. the importance of recognising comme ...1979518110
mechanisms of resistance to corynebacterium kutscheri in mice.involvement of the mononuclear phagocyte system in the mechanism of resistance to corynebacterium kutscheri was studied in c57b1/6 and swiss lynch mice. a major difference between the two mouse strains was that the phagocytic cells of the livers of c57b1/6 mice destroyed the bacteria with much greater efficiency. there was no evidence of serum factors which might have led to this greater bacterial killing observed in the c57b1/6 mice, and in vivo phagocytosis of c. kutscheri was identical in bot ...1977892907
tripeptide hydroxamate from corynebacterium kutscheri.a tripeptide hydroxamate was isolated from cultures of corynebacterium kutscheri grown on an iron-limiting medium. the metabolite was characterized by spectral measurements and by chemical degradation as l-alpha-aspartyl-l-alpha-n-hydroxy-aspartyl-d-cycloserine.1979762013
[serological examinations on natural infections with mouse pathogens in inbred mouse strains: difference in antibody detection among the strains (author's transl)].serological surveys on several infections were performed on the inbred mouse strains maintained at the central institute for experimental animals. in the first survey, 11 strains of mouse, which were 8 weeks of age or older and were kept in separate cages in the same animal room, were tested for antibodies to salmonella enteritidis, corynebacterium kutscheri, tyzzer's organisms, mycoplasma pulmonis, mouse hepatitis virus (mhv), sendai virus (hvj), pneumonia virus of mice (pvm) and minute virus o ...1978631200
corynebacterium kutscheri infection in the mouse. i. report of an outbreak, bacteriology, and pathology of spontaneous infections. 19684233851
detection of corynebacterium kutscheri in animal tissues by dna-dna hybridization.corynebacterium kutscheri, a pathogen of experimental rats and mice, is difficult to detect in the early stages of infection. a diagnostic assay was developed to reveal the organism in tissues of asymptomatic, infected animals. three fragments of dna specific to c. kutscheri were isolated, radiolabeled with 32p, and used in dna-dna hybridization assays with blots of impression smears of animal tissues on membrane filters. the c. kutscheri probes did not cross-hybridize with 15 dna isolates from ...19863771763
corynebacterium kutscheri infection in the mouse. ii. diagnostic serology. 19684233852
comparison of methods to diagnose an epizootic of corynebacterium kutscheri pneumonia in rats.an outbreak of corynebacterium kutscheri pneumonia occurred in a colony of laboratory rats. diagnostic methods compared on a prospective basis included (1) an enzyme-linked immunosorbent assay (elisa) for serum antibody to c. kutscheri; (2) c. kutscheri isolation from retrograde nasal wash, cervical lymph nodes, tracheal wash, lung homogenate; and (3) histopathology. c. kutscheri was isolated from one or more of the cultured sites from suspected cases, but no individual rat yielded c. kutscheri ...19873586609
characterization of a haemophilus sp. isolated from a rabbit with conjunctivitis.a case of conjunctivitis in a rabbit caused by a haemophilus sp. is described. this was the only organism that was isolated in large numbers from the infected eye. the uninfected eye of the same rabbit contained staphylococcus epidermidis, corynebacterium kutscheri, proteus mirabilis and a neisseria sp. effects of infection with live haemophilus sp. isolated from the subject rabbit was studied in the eyes of rabbits and mice. swabbing live organisms in the normal rabbit eye produced blepharitis ...19863724056
the effect of selected viruses on corynebacterium kutscheri infection in rats.the influence of selected viral pathogens on rats that were previously infected with corynebacterium kutscheri was investigated. a series of three separate experiments were performed to test the effect of sialodacryoadenitis virus, sendai virus and rat virus. in each experiment, weanling rats were divided into three groups (c. kutscheri-inoculated, virus-inoculated and c. kutscheri plus virus-inoculated). two groups were inoculated oronasally with c. kutscheri to establish subclinical infections ...19882848153
comparative examinations of virulent corynebacterium kutscheri and its presumed avirulent variant. 19695796125
response of mice to corynebacterium kutscheri on footpad injection. 19734351473
[symposium: corynebacterium kutscheri infection in mouse-rat colonies. 2. ulcerative colitis]. 19744376491
nonspecific stimulation of host defense by corynebacterium kutscheri. i. antitumor effect.the effect of local injection of formalin-killed corynebacterium kutscheri (fk.ck) on mouse survival after the intraperitoneal inoculation of ehrlich ascites carcinoma in outbred ddy mice or p388 leukemia cells in inbred cdf1 mice was investigated. treatment of mice in the dose range of greater than 10(6) organisms per mouse conferred the substantial protection on both mice. the initial phase of antitumor effect consisted of the marked increase in the number of peritoneal exudate cells and the e ...19892622460
[peroral infection of corynebacterium kutscheri in mice. ii. in vivo bacterial activities and manifestation of occult infection]. 19751240184
[corynebacterium kutscheri infection in the wistar rat]. 19854018249
[peroral infection of fasted and cortisone-treated mice with corynebacterium kutscheri (author's transl)]. 19744473352
naturally occurring subclinical corynebacterium kutscheri infection in laboratory rats: strain and age related antibody response.naturally occurring subclinical corynebacterium kutscheri infection was analyzed by antibody response related to the strain of rats. wistar-lewis, wistar and spraque-dawley rats were high responders in seroconversion rates and antibody titers, while brown norway and fischer rats were low responders. the antibody response was related to age also. some young rats had maternal antibody to c. kutscheri, but antibody disappeared before 8 weeks of age. rats were antibody-negative for several months th ...19882966878
[pseudotuberculosis in mice. isolation of corynebacterium kutscheri from the oral cavity and the skin of sick and aparently healthy animals]. 19751235973
nonspecific stimulation of host defense by corynebacterium kutscheri. ii. isolation of the active moiety.the isolation and determination of biological activities of the active component of corynebacterium kutscheri were attempted in the present investigation. the antitumor effect was confined to the subcellular particle fraction of this bacterium and was associated with a molecule of glycoprotein nature (40,000-38,000 daltons) isolated from this fraction by affinity chromatography with concanavalin a-sepharose 4b. this substance exerted mitogenic activity on c3h/hej splenocytes and t cells, stimula ...19902087246
inherited resistance to corynebacterium kutscheri in mice.an analysis of the factors responsible for inherited resistance to corynebacterium kutscheri was undertaken. various inbred mouse strains were examined; these included the swiss lynch and c57bl/l mice, their f1 and f2 progeny, and the progeny of the f1 backcrossed to each parent strain. two modes of inherited resistance are described. an examination suggested that resistance as measured by the mean lethal dose of c. kutscheri was under polygenic control and was inherited continuously. however, t ...1976971958
isolation of corynebacterium kutscheri from aged syrian hamsters (mesocricetus auratus).corynebacterium kutscheri was isolated from the oral cavities of 12 male syrian hamsters (mesocricetus auratus) which were about 12 months old. at 1, 5, and 9 months after initial isolation of c. kutscheri from the oral cavity, hamsters were euthanatized, and attempts were made to culture c. kutscheri from 13 additional sites. corynebacterium kutscheri was isolated from nine hamsters, and regardless of the hamsters' ages, the organisms were most frequently isolated from the oral cavity (100%), e ...19911658468
[symposium: corynebacterium kutscheri infection in mouse-rat colonies. 4. detection of corynebacterium contamination by cortisone treatment and fluorescent antibody technic]. 19744617685
corynebacterium kutscheri and its alleged avirulent variant in mice.corynebacterium kutscheri and its alleged avirulent variant were re-examined in c57bl/6 and swiss lynch mice. it was confirmed that while c57bl/6 mice were resistant and swiss lynch susceptible to c. kutscheri, the alleged atypical variant was avirulent in both mouse strains. however, following immunosuppression of c57bl/6 mice with hydrocortisone acetate, it was not possible to reactivate latent c. kutscheri or the alleged atypical variant; this was contrary to previous reports. moreover, seque ...1978649947
[symposium: corynebacterium kutscheri infections in mouse-rat colonies. 1. varieties of infections]. 19744477533
[symposium: corynebacterium kutscheri infection in mouse-rat colonies. 3. conditions for peroral transmission]. 19744477534
[latent infection with corynebacterium kutscheri in mice after peroral inoculation and its provocation by cortisone (author's transl)].latent infection with corynebacterium kutscheri in mice and its provocation by cortisone were studied with a rifampicin-resistant strain of the organism. mice having been infected perorally began to excrete the organisms in feces within 6 hours, and most of them were found to be carrying the organisms in the intestine, especially in the cecum even 90 days after infection. in such state of latency, however, no organisms were detected in other main organs, and neither visible lesions nor serum agg ...19751238258
[seromonitoring of laboratory mouse and rat colonies for common murine pathogens (author's transl)].during a period from 1973 to 1978, 392 and 225 lots including 12,232 mouse and 8,044 rat individual sera, respectively, were examined for antibodies to murine hepatitis virus, sendai virus, bordetella bronchiseptica, mycoplasma pulmonis, tyzzer agents, salmonella typhimurium and corynebacterium kutscheri. of mouse lots 94.5% and 39.3% from breeder and user colonies, respectively, were negative for all antibodies examined as well as 31.6% and 17.2% of rat breeder and user colonies, respectively. ...1979225183
[pathological studies on corynebacterial ulcerative entero-colitis in rats treated with acth (author's transl)].ulcerative entero-colitis was developed in 6-week-old male sprague-dawley rats treated daily with acth (4 mg/kg. s. c.) as well as necrotic purulent lesions in liver, kidney, lung or heart. incidence of ulcerative lesions was 6.3% in farm-a rats and 56% in farm-b rats. although ulcerative lesions were mostly observed in cecum, the similar lesions were also detected in distal ileum or proximal colon in some cases. histologically, the lesions were characterized by focal necrosis demarcated from su ...1975174920
[miliary abscesses in kidneys of white rats induced by an aerobic corynebacterium related to corynebacterium kutscheri]. 195713470470
comparative effects of corticosteroids on host resistance to infection in relation to chemical structure.in a comparative study concerning the effect of corticosteroids on host resistance to infections, five compounds were found to decrease host resistance, while three did not have this property, although all eight compounds were highly antiinflammatory. the compounds capable of decreasing host resistance were (i) hydrocortisone acetate; (iii) 9alpha-fluoro, 16alpha-methylprednisolone acetate; (iv) 9alpha-fluoro, 16alpha-hydroxyprednisolone; (v) 9alpha-fluoro, 16alpha-hydroxyprednisolone, 16alpha-1 ...19674960741
[comparative degrees of resistance offered in vitro by macrophages from normal and vaccinated mice to infection by listeria monocytogenes or corynebacterium kutscheri]. 196414190541
[model infection with corynebacterium kutscheri in the mouse]. 19751224830
[symposium: corynebacterium kutscheri infection in mouse-rat colonies. 5. detection of bacterial contamination by serum antibody analysis]. 19744477535
antigenic heterogeneity of corynebacterium kutscheri from mice and rats. 1977302795
[experimental infection by corynebacterium kutscheri in mice]. 19685264778
pneumonia in rats due to infection with corynebacterium kutscheri. 19685749197
[cellular resistance to bacterial infection. iv. active immunization and resistance of the macrophages of ncs mice to the intracellular multiplication of listeria monocytogenes, corynebacterium kutscheri and brucella melitensis]. 19665903387
the role of complement in resistance to endogenous and exogenous infection with a common mouse pathogen, corynebacterium kutscheri.in mice, the presence or absence of a single complement (c') component, called hc(1), is controlled by two alleles at the hc locus. the sera of mice which lack this c' component do not manifest c'-mediated immune hemolysis. when challenged with the common mouse pathogen, corynebacterium kutscheri, mice possessing hemolytic c' fare slightly better than c'-deficient mice. when mice harboring latent c. kutscheri are administered hydrocortisone, which depresses mouse serum c' levels, pseudotuberculo ...19665922289
effect of a microbial growth inhibitory factor on the cyclic nucleotide metabolism of peritoneal macrophages.precultured mouse peritoneal macrophages were incubated with a microbial growth inhibitory lymphokine prepared from cell-free ascites of rat zajdela hepatoma. cyclic nucleotide metabolism was followed in parallel to experiments demonstrating inhibition of intracellular growth of corynebacterium murium kutscheri. maximum increase of camp, adenylate cyclase and camp-phosphodiesterase activities was found after 60 to 90 min, while inhibition of microbial growth was evident only after 2-3 h. both ef ...19806261501
effect of stearoyl-n-acetylmuramyl-l-alanyl-d-isoglutamine on host resistance to corynebacterium kutscheri infection in cortisone-treated mice.opportunistic corynebacteriosis was induced successfully by infection with corynebacterium kutscheri in cortisone-treated mice and the ability of stearoyl-n-acetylmuramyl-l-alanyl-d-isoglutamine derivatives in phosphate buffered saline (pbs) solution or encapsulated into liposomes for restoring impaired resistance was examined. 6-o-stearoyl-n-acetylmuramyl-l-alanyl-d-isoglutamine (l18-mdp) in liposomes and n alpha-acetyl muramyl-l-alanyl-d-isoglutaminyl-n epsilon-stearoyl-l-lysine (mdp-lys-l18) ...19846531965
naturally occurring tyzzer's disease in a clean mouse colony: high mortality with coincidental cardiac lesions.light and electron microscopic examinations were performed on tissues from 12 young mice which were affected by naturally-occurring tyzzer's disease. eight of the 12 mice had cardiac lesions which have not previously been reported in mice and which caused a high mortality. the cardiac lesions were detected in mice which had severe and advanced intestinal lesions which penetrated the deeper mucosa and muscular layer with active regeneration of the mucosal epithelium. periodical serological tests ...19836643751
an enzyme linked immunosorbent assay for detection of antibodies to corynebacterium kutscheri in experimentally infected rats.an enzyme-linked immunosorbent assay (elisa) which detects rat antibody to corynebacterium kutscheri was developed and compared with a tube agglutination assay in two infectivity studies. in four groups of rats inoculated intratracheally with 100-fold dilutions of corynebacterium kutscheri , mortality, lesions, and recovery of corynebacterium kutscheri were confined to the two highest dose groups. five of 17 (29%) test rats seroconverted within 14 to 21 days post-inoculation as assayed by elisa; ...19846716955
corynebacterium kutscheri infection in wild voles (microtus agrestis). 19817013898
disproportionate growth of organs and body weight following glucocorticoid treatment of the rat fetus.the effects of pharmacologic doses of dexamethasone, betamethasone, and cortisone given to pregnant rats on gestation days 12 and 13 were studied in mothers and fetuses on gestation day 21. dexamethasone and betamethasone treatment resulted in a significant decrease in maternal and fetal weight gain, occurrence of cleft palate and omphalocele, and impaired growth of fetal heart, liver, adrenals, kidneys, and skeletal muscle. cortisone produced fewer developmental defects and less impairment of g ...19827117095
serological studies of corynebacterium kutscheri and coryneform bacteria using an enzyme-linked immunosorbent assay (elisa).an enzyme-linked immunosorbent assay (elisa) to measure corynebacterium kutscheri antibodies in mice and rats was developed. seven c. kutscheri isolates showed considerable serological relationship, but japanese isolates differed from the british isolates. the elisa appeared specific since c. kutscheri antigen did not react with antisera against 8 heterologous coryneform species. antibodies to c. kutscheri were to a limited extent absorbed by autologous and homologous antigen, but not at all by ...19957564214
pathogenicity of corynebacterium kutscheri in the syrian hamster.the pathogenicity of corynebacterium kutscheri isolated for the first time from syrian hamster was experimentally studied in hamsters. in hamsters given intramuscular (i.m.) or subcutaneous (s.c.) inoculation with 10 or 10(3) bacteria, neither clinical signs nor gross lesions were found. in those given 10(5) bacteria i.m., moderate proliferation of granulation tissue was found in the muscle of the inoculation region at necropsy. in the animals given 10(5) bacteria s.c., a nodular lesion was obse ...19958519904
[cellular resistance to bacterial infection. i. resistance opposed to the development of corynebacterium kutscheri after its ingestion by mouse macrophages of different origins]. 196414129152
corynebacterial pseudotuberculosis in mice. i. comparative susceptibility of mouse strains to experimental infection with corynebacterium kutscheri.the susceptibility of mice to experimental infection with corynebacterium kutscheri was studied by comparing the host response to this organism of mice obtained from 31 different colonies, representing 15 different genetic types. a standardized infective dose, administered intravenously, made it possible to separate the animals into two sharply differentiated groups. all the animals of the following colonies died: swiss lynch, swiss r/j, a/jax, princeton, rfvl, and cf(1) (spf). all the animals o ...196414206441
corynebacterial pseudotuberculosis in mice. ii. activation of natural and experimental latent infections.latent corynebactenai infection occurs naturally in many strains of mice. it can be evoked into the active disease, pseudotuberculosis, by a single injection of 10 mg of cortisone. the cortisone effect was tested in 21 colonies, representing 11 genetically different strains of mice. animals of the c57b1/6, dba/2, and riii strains were shown to be latently infected with corynebacterium kutscheri by the fact that they developed fatal pseudotuberculosis following cortisone treatment. virulent c. ku ...196414208250
effects of indomethacin on acute, subacute, and latent infections in mice and rats.the comparative effect of indomethacin and hydrocortisone on the resistance of mice or rats to various acute, subacute, and latent bacterial infections was investigated. large daily doses of indomethacin and hydrocortisone administered to mice challenged with bacterial pathogens, including klebsiella pneumoniae ad, salmonella schottmuelleri 3010, staphylococcus aureus (smith), streptococcus pyogenes c203, salmonella pullorum #2, proteus vulgaris 1810, and pseudomonas aeruginosa 2616, revealed th ...19685663575
on some spontaneous infections observed in mice; corynebacterium kutscheri and corynebacterium pseudotuberculosis. 195015433253
upregulation of galectin-3 by corynebacterium kutscheri infection in the rat lung.corynebacterium (c) kutscheri and staphylococcus aureus were isolated from two sprague-dawley (sd) rats with a hemisected spinal cord. grossly, gray-white bulging foci and abscesses were distributed throughout the parenchyma of the lung. pathologically, severe necrotizing lobar pneumonia with abscesses and fibrinous pleuritis were observed. immunohistochemical analysis found accumulation of galectin-3 in alveolar macrophages and the alveolar interstitial region. no other viral or bacterial patho ...200717460353
a genetic study of susceptibility to experimental tuberculosis in mice infected with mammalian tubercle bacilli.a study has been made of the genetic aspects of the difference between two inbred strains of mice (c57b1/6 and swiss) in response to experimental infection with mammalian tubercle bacilli. males and females, 4 to 6 weeks of age were inoculated intravenously with 0.2 ml of a 1/50 culture dilution of mycobacterium tuberculosis var. bovis (vallée strain) grown in tween albumin medium. mean survival time for c57b1 animals was 28.1 +/- 0.6 days and for swiss, 55.3 +/- 0.6 days postinfection. the char ...196514319402
biosurfactant production by corynebacterium kutscheri from waste motor lubricant oil and peanut oil cake.production and characterization of biosurfactant from renewable sources.200717944837
detection of corynebacterium kutscheri in the faeces of subclinically infected mice.mice were infected experimentally and subclinically with corynebacterium kutscheri to recover the organism from mice faeces. the faeces were then cultured using selective furazolidone-nalidixic acid-colimycin agar. the number of c. kutscheri per gram of fresh faeces varied from mouse to mouse, but once established in the intestine, the organism was excreted in the faeces for at least five months. viable bacteria were detected in most of the faecal samples, including those stored in the animal ro ...200818625593
effect of biosurfactant and fertilizer on biodegradation of crude oil by marine isolates of bacillus megaterium, corynebacterium kutscheri and pseudomonas aeruginosa.this study was conducted to investigate the effects of fertilizers and biosurfactants on biodegradation of crude oil by three marine bacterial isolates; bacillus megaterium, corynebacterium kutscheri and pseudomonas aeruginosa. five sets of experiments were carried out in shake flask and microcosm conditions with crude oil as follows: set 1-only bacterial cells added (no fertilizer and biosurfactant), set 2-with additional fertilizer only, set 3-with additional biosurfactant only, set 4-with add ...201020863694
metal biouptake by actively growing cells of metal-tolerant bacterial strains.metal uptake potentials of pseudomonas aeruginosa ca207ni, burkholderia cepacia ca96co, rhodococcus sp. al03ni, and corynebacterium kutscheri fl108hg were studied to determine their competence in detoxification of toxic metals during growth. metabolism-dependent metal biouptake of the bacteria revealed appreciable uptake of the metals (57-61, 10-30, 23-60, and 10-16 mg g dw(-1) of ni(2+), cr(6+), co(2+), and cd(2+), respectively) from medium, after initial drop in ph, without lag phase. the bact ...201526209420
corynebacterium kutscheri infection of skin and soft tissue following rat bite.corynebacterium kutscheri is a common bacterium isolated from the oral cavity of healthy mice and rats. we report the first well-documented case of c. kutscheri human infection which followed a rat bite. the microorganism was identified by conventional biochemical tests and confirmed by 16s rrna gene sequence analysis.200717670928
the pathogenic effects of mycobacterium haemophilum in immunosuppressed albino mice.of 30 prednisolone-treated mice challenged intravenously with mycobacterium haemophilum, 12 developed skin lesions, primarily on the ears, from which the mycobacterium was isolated. these lesions were not observed in mice challenged with m. haemophilum but not given prednisolone. m. haemophilum infection prolonged the life and reduced the frequency of intercurrent infection with corynebacterium murium in prednisolone-treated mice.19807431372
murine tumorlytic factor, immunologically distinct from tumor necrosis factor-alpha and -beta, induced in the serum of mice treated with a t-cell mitogen of corynebacterium kutscheri.murine tumorlytic factor (tf), immunologically distinct from murine tumor necrosis factor (tnf)-alpha and -beta, was purified to a homogeneity from the serum of mice injected with a t-cell mitogen of corynebacterium kutscheri. the treated mouse serum was purified by lentil lectin-sepharose chromatography, deae-cellulose chromatography, preparative isoelectric focusing, and high-pressure liquid chromatography to the specific activity of 1.5 x 10(6) u/mg protein. tf was 42 kda in its oligomeric fo ...19957590903
natural and subclinical corynebacterium kutscheri infection in rats.distribution of corynebacterium kutscheri was determined in 41 rats housed in a conventionally managed colony that were infected naturally and subclinically. at 2, 5, 10, 20 and 25 months after initial isolation of c. kutscheri, attempts were made to isolate c. kutscheri from 17 sites, with a new selective medium, fnc agar. in total, the prevalence (97.6%) of c. kutscheri isolation was significantly (p < 0.001) higher than the frequency (70.7%) of antibody detection. none of the rats manifested ...19957752607
natural habitats of corynebacterium kutscheri in subclinically infected icgn and dba/2 strains of mice.subclinically infected mice of icgn and dba/2 strains housed in a conventionally managed colony were examined to determine natural habitats of corynebacterium kutscheri. at 5, 7, 9, 12 and 13 months after initial isolation of the organism from oral cavity and cecal contents of five icgn mice, attempts were made to isolate c. kutscheri from 19 sites using a new selective medium, furazolidone-nalidixic acid-colimycin agar. from the initial survey to 13 months, c. kutscheri was isolated from 27 of ...19957752617
[differences in susceptibility of mice among various strains to oral infection with corynebacterium kutscheri].differences in susceptibility of female mice among 10 strains to corynebacterium kutscheri infection were studied pathologically and bacteriologically. twenty mice of each strain were inoculated orally with 4 x 10(5.0) cfu of the bacteria. the gross lesions were observed in 60.0% of balb/c-nu/nu mice, 25.0% of cba/n mice, 10.0% of mps mice, and 5.0% of a/j and c3h/he mice, while balb/ccr, c57bl/6cr, b10.br/sgsn, ddy and icr mice showed neither clinical signs nor gross lesions. six balb/c-nu/nu, ...19938253131
sex differences in susceptibility of icr mice to oral infection with corynebacterium kutscheri.sex difference in susceptibility to oral infection with corynebacterium (c.) kutscheri was experimentally studied in icr mice. immature (4-week-old) and adult (14-week-old) mice were inoculated with two infecting doses of c. kutscheri, and necropsied for bacteriological and serological survey 4 weeks after the bacterial infection. no macroscopic lesions at necropsy were demonstrated, except for one adult male given 10(9) bacteria. in immature mice, c. kutscheri isolated from the oral cavity and ...199910067204
detection of corynebacterium kutscheri from the oral cavity of rats.a simple and useful method for the detection of c. kutscheri from the oral cavity of living rats was devised. in 10 sacrificed rats from two naturally and subclinically infected conventional colonies, 10(4.28) or 10(3.84) cfu/ml c. kutscheri were isolated from upper incisor swab extractions, while 10(1.38) or 10(1.58) and < 10 or 10(1.56) cfu/ml from the upper soft palate and pharynx, respectively. in another survey with 26 living animals, which were reared on the same rack, organisms were detec ...200211871160
role of il-10 deficiency in pneumonia induced by corynebacterium kutscheri in mice.il-10 is an important anti-inflammatory cytokine that can inhibit the production of many pro-inflammatory cytokines. both human and animal studies have shown that pro-inflammatory cytokines play an important role in pneumonia and other inflammatory lung diseases. in the present study, il-10 knockout (ko) and wild-type mice were infected with corynebacterium kutscheri to determine whether the severity of pathogenesis and whether protective immunity could be altered in the absence of il- 10. the s ...200919421001
biodegradation of petroleum hydrocarbons in the presence of nickel and cobalt.bioremediation of environments co-contaminated with hydrocarbons and heavy metals often pose a challenge as heavy metals exert toxicity to existing communities of hydrocarbon degraders. multi-resistant bacterial strains were studied for ability to degrade hydrocarbons in chemically defined media amended with 5.0 mm ni(2+), and co(2+). the bacteria, pseudomonas aeruginosa ca207ni, burkholderia cepacia al96co, and corynebacterium kutscheri fl108hg, utilized crude oil and anthracene without lag pha ...201323457074
chromium (vi) biosorption properties of multiple resistant bacteria isolated from industrial sewerage.chromium (vi) [cr (vi)] biosorption by four resistant autochthonous bacterial strains was investigated to determine their potential for use in sustainable marine water-pollution control. maximum exchange between cr (vi) ions and protons on the cells surfaces were at 30-35 °c, ph 2.0 and 350-450 mg/l. the bacterial strains effectively removed 79.0-90.5 % cr (vi) ions from solution. furthermore, 85.3-93.0 % of cr (vi) ions were regenerated from the biomasses, and 83.4-91.7 % of the metal was adsor ...201323315153
complete genome sequence of corynebacterium kutscheri dsm 20755, a corynebacterial type strain with remarkably low g+c content of chromosomal dna.the complete genome sequence of the type strain corynebacterium kutscheri dsm 20755 comprises 2,354,065 bp and 2,047 protein-coding genes. the mean g+c content of the chromosomal dna is 46.46%, which is the lowest value detected so far in a member of the genus corynebacterium.201526021937
rapid identification of klebsiella pneumoniae, corynebacterium kutscheri, and streptococcus pneumoniae using triplex polymerase chain reaction in rodents.klebsiella pneumoniae, corynebacterium kutscheri, and streptococcus pneumoniae are important pathogens that cause respiratory infections in laboratory rodents. in this study, we used species-specific triplex pcr analysis to directly detect three common bacterial pathogens associated with respiratory diseases. specific targets were amplified with conventional pcr using the tyrb gene from k. pneumoniae, gyrb gene from c. kutscheri, and ply gene from s. pneumoniae. our primers were tested against p ...201323357944
modulation of immune response by interleukin-10 in systemic corynebacterium kutscheri infection in mice.interleukin (il)-10 is an anti-inflammatory cytokine that modulates sepsis by decreasing pro-inflammatory cytokine production and chemokine expression. in this study, il-10-deficient and wild-type (wt) mice were infected with corynebacterium kutscheri to determine if the absence of il-10 altered the protective immunity and pathogenesis. after infection, il-10 knockout (ko) mice had a higher survival rate than wt mice. the decrease of body weight and the increased weight of organs such as liver a ...201222538660
epidemiological study of common diseases and their risk factors in camels in south punjab, pakistan.bacteriological study of mastitis along with common blood protozoan diseases were studied in dromedary camels in cholistan, dera ismail khan and rahim yar khan districts in south punjab, pakistan. for this purpose 300 camels were sampled randomly at different common grazing and watering point. for study of blood parasites clinically suspected and apparently healthy camels, 150 each, were sampled. an overall prevalence of 15%and 5% was recorded for trypanosomiasis and anaplasmosis respectively. t ...201728428133
effect of weak acid hypochlorous solution on selected viruses and bacteria of laboratory rodents.weak acid hypochlorous solution (wahs) is known to have efficacy for inactivating pathogens and to be relatively safe with respect to the live body. based on these advantages, many animal facilities have recently been introducing wahs for daily cleaning of animal houses. in this study, we determined the effect of wahs in inactivating specific pathogens of laboratory rodents and pathogens of opportunistic infection. wahs with an actual chloride concentration of 60 ppm and a ph value of 6.0 was ge ...201424770639
corynebacterium kutscheri invasiveness of the gastrointestinal tract in young mice.corynebacterium kutscheri invasiveness of the tissues of the gastrointestinal tract in mice was investigated by the fluorescent antibody technique. the invasion was clearly recognized in 3-week-old mice infected intragastrically along with gastric mucin and a subcutaneous dose of cortisone; 10(7) organisms caused a notable invasion of the gastric and duodenal tissues. furthermore, marked bacterial invasion of the large intestine appeared in mice challenged perorally with 7 x 10(7) organisms.19827140829
[isolation of a corynebacterium kutscheri strain in a guinea pig]. 19695376150
[isolation of a strain of corynebacterium kutscheri in a guinea pig]. 19695408487
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