| ecology of keystone virus, a transovarially maintained arbovirus. | our studies in the pocomoke cypress swamp of maryland have shown that key strain of ce is endemic and is carried by the floodwater mosquito a. atlanticus. the virus is transmitted transstadially in nature, as evidenced by our recovery of virus from larvae and males of this species. serologic evidence, both here and elsewhere, indicates that vertebrates are infected with key, but their role in the transmission cycle remains unknown. we have found several animals, for example, the gray squirrel, t ... | 1975 | 20017 |
| ecology of california encephalitis viruses on the del mar va peninsula. i. virus isolations from mosquitoes. | the ecology of california encephalitis viruses was studied on the del mar va peninsula. adult mosquitoes were collected weekly from may to october of 1971 and monthly from may to october of 1972, using cdc miniature light traps with dry ice. floodwater mosquitoes were assayed for virus in suckling mice or cell cultures. in 1971 over 77,000 mosquitoes were processed, resulting in 33 virus isolations. in 1972, over 106,000 were processed and 63 virus strains were recovered. of the 1971 strains, al ... | 1975 | 234205 |
| experimental infection of vertebrates of the pocomoke cypress swamp, maryland with keystone and jamestown canyon viruses. | experimental studies were conducted to assess the susceptibility of white-tailed deer (odocoileus virginianus), gray squirrels (sciurus carolinensis), and cottontail rabbits (sylvilagus floridanus) to jamestown canyon (jc) and/or keystone (key) virus infection. viremia occurred in 5 of 6 deer inoculated with jc virus; however, all deer developed key virus neutralizing antibody. based on the observation that antibody elicited by primary infection of deer with either key or jc virus exhibited part ... | 1979 | 453437 |
| towards a quantitative understanding of the epidemiology of keystone virus in the eastern united states. | the implications of the keystone virus--aedes atlanticus transmission cycle are explored in the context of a quantitative model. among the variables considered are the vertical transmission rate, the effect of the virus upon vector fertility and survival, vector densities and distributions, the proportion susceptible in the vertebrate population, the attractiveness of different vertebrates to the vector and vector survival rates. the logical relationships between these several variables are expl ... | 1978 | 646025 |
| natural transmission of keystone virus to sentinel rabbits on the delmarva peninsula. | domestic rabbits were exposed in the pocomoke cypress swamp from early may through october 1973, to act as sentinel indicators of keystone (key) virus transmission on the delaware-maryland-virginia (delmarva) peninsula. rabbits were bled weekly and their sera were tested for the presence of neutralizing antibody to both key and james-town canyon (jc) viruses. adult mosquito activity was monitored concurrently by cdc miniature light traps with dry ice. of 100 rabbits exposed, 20 rabbits acquired ... | 1978 | 717629 |
| arbovirus surveillance in florida: wild vertebrate studies 1965-1974. | wildlife species from 38 of florida's 67 counties were surveyed over a 10 year period for the presence of antibody to the five major arboviruses circulating in the state. the routine screening of 7891 sera from wild birds and mammals via the hemagglutination-inhibition (h1) test with selected reactors subjected to serum neutralization testing has 1) provided information regarding geographic distribution and seasonality of circulation of these viruses 2) identified enzootic foci of infection and ... | 1975 | 1152173 |
| the ecology and behavior of aedes atlanticus d. & k. and other species with reference to keystone virus in the houston area, texas. | | 1975 | 1223304 |
| monoclonal antibody characterization of jamestown canyon (california serogroup) virus topotypes isolated in canada. | jamestown canyon (jc) virus of the california (cal) serogroup has been isolated in 12 american states and 6 canadian provinces. a study was undertaken to produce monoclonal antibodies (mabs) to jc virus and to use these mabs to assay for possible heterogeneity among naturally occurring jc topotypes in canada. mabs were produced to the prototype strain of jc virus using balb/c mice. twenty-seven secreting mabs were obtained and three of these mabs were propagated and studied. all three mabs, m1 ( ... | 1992 | 1418321 |
| maintenance and transmission of keystone virus by aedes atlanticus (diptera: culicidae) and the gray squirrel in the pocomoke cypress swamp, maryland. | | 1988 | 3144600 |
| the population dynamics of two vertically transmitted infections. | the transmission of keystone virus in the mosquito aedes atlanticus and of rickettsia rickettsii in the tick dermacentor andersoni is modeled and analyzed. both of these infections can be transmitted vertically from an infective parent to newborn offspring as well as horizontally via direct or indirect contacts with infected individuals. the vertical transmission mechanism plays a major role in the maintenance of these infections and its effects are analyzed in detail. this same mechanism can ac ... | 1988 | 3148206 |
| penetration of keystone virus in artificially infected female aedes inirmatus (dyar and knab). | | 1969 | 5775477 |
| potentiation of keystone virus infection in cotton rats by glucocorticoid-induced stress. | cotton rats (sigmodon hispidus) were treated daily with corticosteroids and then inoculated with keystone virus. viremia and neutralizing antibody profiles were determined in treated and untreated rats. compared to untreated rats, the treated rats were substantially more susceptible to infection, and their viremia lasted much longer. this experimental model suggests that stress associated with excess glucocorticoid synthesis within a natural population could cause an increase in transmission of ... | 1982 | 7047766 |
| serologic evidence of jamestown canyon and keystone virus infection in vertebrates of the delmarva peninsula. | serological data accumulated during the past decade indicated that a variety of feral and domestic animals of the delaware-maryland-virginia (delmarva) peninsula were infected with jamestown canyon (jc) and/or keystone (key) viruses (bunyaviridae, california serogroup). neutralizing (n) antibody to jc virus was most prevalent in white-tailed deer, sika deer, cottontail rabbits and horses. key virus n antibody was detected most frequently in gray squirrels and domestic goats. n antibody indicativ ... | 1982 | 7149110 |
| determination and comparative analysis of the small rna genomic sequences of california encephalitis, jamestown canyon, jerry slough, melao, keystone and trivittatus viruses (bunyaviridae, genus bunyavirus, california serogroup). | the nucleotide sequences of the small (s) genomic rnas of six california (cal) serogroup bunyaviruses (bunyaviridae: genus bunyavirus) were determined. the s rnas of two california encephalitis virus strains, two jamestown canyon virus strains, jerry slough virus, melao virus, keystone virus and trivittatus virus contained the overlapping nucleocapsid (n) and non-structural (nss) protein open reading frames (orfs) as described previously for the s rnas of other cal serogroup viruses. all n prote ... | 1995 | 7897347 |
| first complete genome sequences of two keystone viruses from florida. | we report here the first complete sequences of two keystone virus (keyv) genomes isolated from florida in 2005, which include the first two publicly available complete large (l) gene sequences. the sequences of the keyv l segments show 75.99 to 83.86% nucleotide similarity with those of other viruses in the california (cal) serogroup of bunyaviruses. | 2015 | 26514762 |
| ecology of california encephalitis viruses on the del mar va peninsula. ii. demonstration of transovarial transmission. | the high rate of keystone virus recovery from aedes atlanticus collected in 1971 and 1972 suggested that these mosquitoes might be emerging infected. to demonstrate the suspected transovarial transmission of this virus, developmental stages of a. atlanticus were collected from the field. larvae were identified and pooled for virus isolation in suckling mice. pupae were allowed to emerge in the laboratory, then were segregated by sex and pooled for virus isolation. keystone virus was recovered fr ... | 1975 | 1111352 |
| california group arboviruses in florida and report of a new strain, keystone virus. | | 1966 | 4957255 |