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mosquito-borne viruses in finland.inkoo virus, the finnish representative of the california group, was isolated from a pool of aedes communis/punctor. it is distinguishable from tahyna, california encephalitis, trivittatus and melao viruses, but seems to be antigenically related to the jamestown canyon virus. the prevalence of inkoo antibodies increases towards the north in both human beings (16% to 69%) and cows (37% to 88%). inkoo antibodies are common also in other mammals of large size (reindeer, moose, foxes), less frequent ...19751207184
serologic survey for selected arboviruses and other potential pathogens in wildlife from mexico.during 1988 and 1989, a serologic survey of wildlife was conducted in northeastern mexico to determine the presence, prevalence, and distribution of arboviruses and other selected disease agents. eighty mammal specimens were tested. antibodies to vesicular stomatitis-indiana, venezuelan equine encephalitis-mena ii, rio grande virus, and vesicular stomatitis-new jersey were detected predominantly in small mammals. deer and mouflon (ovis musimon) had antibodies to bluetongue and epizootic hemorrha ...19921512876
oral transmission of jamestown canyon virus by aedes provocans mosquitoes from northeastern new york.aedes provocans were allowed to feed on a bloodmeal containing 5.6 log10 tcid50/ml of jamestown canyon (jc) virus. after 14 days of incubation at 21 degrees c and 80% rh, 100% (36/36) were midgut infected, 50% (18/36) developed disseminated infections and 50% (9/18) of the latter specimens transmitted virus to capillary tubes. when mosquitoes were intrathoracically inoculated with 6.1 log10 tcid50/ml of jc virus, 100% (40/40) became disseminated infected and 95% (38/40) transmitted virus after 1 ...19911675258
laboratory transmission of jamestown canyon and snowshoe hare viruses (bunyaviridae: california serogroup) by several species of mosquitoes.the ability of 14 species of mosquitoes to biologically transmit jamestown canyon virus was tested. four species not previously described as vectors of that virus transmitted to suckling mice. among membrane-fed mosquitoes with disseminated infections, field-collected aedes canadensis (1/3), anopheles punctipennis (1/12), coquillettidia perturbans (2/14) and a laboratory strain of ae. epactius (19/67) transmitted virus. two species were tested for their ability to transmit snowshoe hare virus: f ...19911675261
serological evidence of california group and cache valley virus infection in minnesota white-tailed deer.blood samples were obtained from 138 white-tailed deer (odocoileus virginianus) harvested at three sites surrounding the greater minneapolis-st. paul, minnesota, metropolitan area (usa) and tested for neutralizing antibody to cache valley virus and three california serogroup (jamestown canyon, la crosse, trivittatus) viruses (bunyaviridae). deer at each site had neutralizing antibody to one or more california serogroup viruses and/or cache valley virus. the majority of adult deer (85%) had antib ...19911906113
isolation of jamestown canyon virus from boreal aedes mosquitoes from the sierra nevada of california.more than 28,000 mosquitoes in four genera were collected from high elevation (greater than or equal to 1,000 m) areas of california during 1988-89 and tested for virus by plaque assay in vero cells. viruses were serogrouped by enzyme immunoassay and serotyped by cross-neutralization. six strains of jamestown canyon virus in the california serogroup were isolated from three species of boreal aedes in the aedes communis group of the subgenus ochlerotatus. all isolates were from mosquitoes collect ...19912035746
isolation of jamestown canyon virus (california serogroup) from aedes mosquitoes in an enzootic focus in michigan.twenty isolates of jamestown canyon virus were obtained from adult females of 5 aedes species collected at the houghton lake wildlife research area, missaukee county, in north-central michigan between 1985 and 1989. fourteen were from aedes provocans, and 6 were from 4 other snowmelt aedes species. one isolate of trivittatus virus and one cache valley-like virus were also obtained. seasonal succession patterns for numerous mosquito species were recorded over 4 years. the temporal association of ...19902230774
incrimination of aedes provocans as a vector of jamestown canyon virus in an enzootic focus of northeastern new york.a 2-year field study was conducted in southern saratoga county, new york, to determine which species of the aedes communis group mosquitoes were potential vectors of jamestown canyon (jc) virus. a total of 23,890 mosquitoes (890 pools) were processed for virus isolation in 1988-89, yielding 17 jc virus isolates from ae. provocans and one isolate each from ae. communis, ae. intrudens and ae. punctor. minimum field infection rates (mfir) and daily mfirs as high as 1:219 and 1:38, respectively, wer ...19902230781
prevalence of neutralizing antibodies against california and bunyamwera serogroup viruses in deer from mountainous areas of california.plaque reduction-serum dilution neutralization was used to evaluate the status of bunyavirus activity in deer in mountainous areas of california. antibodies against 9 bunyaviruses were measured in 337 mule deer (odocoileus hemionus hemionus, o. hemionus californicus, and o. hemionus inyoensis) and black-tailed deer (o. hemionus columbianus). more deer from high mountainous areas had neutralizing antibodies against jamestown canyon virus than did deer from low mountainous areas (23% vs. 9%; p les ...19892496610
studies on the seasonality of culiseta inornata in kern county, california.the seasonal abundance of adult culiseta inornata was markedly bimodal in the san joaquin valley of kern county, california, with minima observed during both summer and midwinter. larvae were abundant in most surface water habitats during winter, but could not be found during summer. the occasional collection of females during summer indicated the persistence of an adult population. the midwinter decrease in adult abundance was attributed to the progressive mortality of the autumnal cohort and d ...19892568394
serologic evidence of arboviral infections in white-tailed deer from central wisconsin.a survey conducted during 1979-1980 on white-tailed deer (odocoileus virginianus) in central wisconsin revealed serological evidence of infection by selected arboviruses. among sera from 41 deer, antibody was detected for jamestown canyon virus (56%) and bunyamwera group virus (80%), demonstrating their continuing endemic activity. antibody for la crosse virus, not found previously in sera from deer in central wisconsin, also was detected (5%) in this study.19892716117
virus-vector-host relationships of aedes stimulans and jamestown canyon virus in a northern indiana enzootic focus.collections of hematophagous diptera at the kingsbury state fish and wildlife area in northern indiana between 1982 and 1984 yielded 118,972 mosquitoes from which 5 isolates of jamestown canyon virus and 3 isolates of trivittatus virus were obtained. all jamestown canyon isolates were from aedes stimulans, including 1 from a pool of newly emerged males and 2 from pools of newly emerged females. these 3 isolates suggest that jamestown canyon virus is transovarially transmitted by ae. stimulans. a ...19862878626
an ecological study of jamestown canyon virus on the delmarva peninsula, with emphasis on its possible vector. 19862879043
changing patterns in mosquito-borne arboviruses.research leading to the current state of knowledge on the epidemiology of la crosse virus (lacv), jamestown canyon virus (jcv) and dengue (den) viruses is summarized in relation to the generally recognized criteria for incriminating vectors. the importance of vector biology and local ecological conditions is emphasized as is the necessity of a good balance between laboratory and field-based studies. the influence of human activity in shaping the epidemiological patterns of all three of these arb ...19862906983
infection of white-tailed deer (odocoileus virginianus) in michigan with jamestown canyon virus (california serogroup) and the importance of maternal antibody in viral maintenance.sera collected from a captive population of white-tailed deer (odocoileus virginianus) penned in the lower peninsula of michigan were assayed over a 29-mo period for neutralizing antibody to california serogroup viruses. in all, 130 individual white-tailed deer were bled one to 22 times between june 1983 and november 1985. of the 130 sampled after active transmission had ceased, or passage of maternal antibody in colostrum had occurred, only one (0.8%), a newborn fawn, had no serum neutralizing ...19873102763
antibodies to arboviruses in an alaskan population at occupational risk of infection.a total of 435 united states geological survey and united states forest service workers in alaska were studied for serologic evidence of past infections with four arboviruses known or suspected to be human pathogens. of the personnel tested, 36 (8.3%) had the neutralizing antibody to jamestown canyon but not snowshoe hare virus, 6 (1.4%) had the antibody to snowshoe hare but not jamestown canyon virus, 53 (12.2%) had the antibody to both viruses, 17 (3.9%) had the antibody to northway virus, and ...19883208197
prevalence of neutralizing antibody to jamestown canyon virus (california group) in populations of elk and moose in northern michigan and ontario, canada.blood samples were collected from free-ranging elk (cervus elaphus) harvested in michigan's northern lower peninsula, from moose (alces alces) relocated from ontario's algonquin provincial park to michigan's upper peninsula, and from moose from michigan's isle royale national park. sera were tested by serum dilution neutralization tests in vero cell culture for neutralizing antibody to california serogroup viruses, in particular jamestown canyon (jc), la crosse/snowshoe hare (lac/ssh), and trivi ...19863503129
production and use of a hemagglutinin for detecting antibody to jamestown canyon virus.a procedure was developed for producing a hemagglutinin for the california serogroup (family bunyaviridae, genus bunyavirus) virus jamestown canyon, a human pathogen. serum samples from humans putatively infected with this virus or with la crosse virus were tested by hemagglutination inhibition. each antigen detected antibody to the respective virus, with little cross-reactivity. these results suggest that both antigens should be used when the hemagglutination inhibition test is applied to the d ...19873624448
isolation of cache valley virus and detection of antibody for selected arboviruses in michigan horses in 1980.blood samples collected in september and november 1980 from 87 horses in southwestern michigan were examined for virus isolation and for plaque-reduction neutralizing antibody against selected arboviruses. cache valley virus was isolated from the blood of a clinically normal horse in st joseph county in september. the age-specific antibody prevalence for cache valley virus indicated enzootic transmission in the study area. the high antibody prevalence and the lack of age-specific antibody preval ...19873631684
experimental assessment of the susceptibility of aedes mosquitoes (diptera: culicidae) to infection with jamestown canyon virus. 19863735354
seroconversion rates to jamestown canyon virus among six populations of white-tailed deer (odocoileus virginianus) in indiana.the annual seroconversion of fawns, yearlings, and adult white-tailed deer (odocoileus virginianus) to jamestown canyon virus (california group) was followed at six indiana sites from 1981 through 1984. in all, sera from 1,642 deer (515 fawns, 618 yearlings, and 509 adults) were tested for neutralizing antibody to three california serogroup viruses: jamestown canyon, la crosse, and trivittatus. virtually all deer with specific neutralizing antibody showed evidence of a prior infection with james ...19873820426
rapid diagnosis of lacrosse encephalitis: detection of specific immunoglobulin m in cerebrospinal fluid.an immunoglobulin m (igm) antibody capture enzyme immunoassay (mac-eia) was developed for the rapid and early diagnosis of lacrosse (lac) virus infections. the mac-eia was a sensitive and specific technique for the detection of igm antibodies to lac virus in cerebrospinal fluid specimens and in acute-phase serum specimens. in a retrospective study, cerebrospinal fluid and acute-phase serum paired samples from 108 patients were tested by the mac-eia and by an igm immunofluorescence assay. the res ...19853902876
jamestown canyon virus (california serogroup) is the etiologic agent of widespread infection in michigan humans.in a sample population of 780 michigan residents tested for neutralizing antibodies to california serogroup viruses, 216 (27.7%) had specific neutralizing antibody to jamestown canyon virus. an additional eight (1.0%) had specific neutralizing to trivittatus virus; none had specific neutralizing antibody to la crosse virus. significantly more male residents than female residents of the lower peninsula had antibody to jamestown canyon virus. the frequency of neutralizing antibody titers fits the ...19863953951
isolation of jamestown canyon virus (a california group arbovirus) from a white-tailed deer. 19734706430
maternal antibody to jamestown canyon virus in white-tailed deer. 19744817669
jamestown canyon virus: the etiologic agent of an emerging human disease? 19836191343
a case of encephalitis in a human associated with a serologic rise to jamestown canyon virus.an 8-year-old girl living in rural southwestern michigan experienced sudden onset of symptoms beginning with headache, dizziness and fever which rapidly progressed to central nervous system involvement with seizures and coma. following 27 days of hospitalization her recovery was uneventful, with no apparent sequelae 15 months after discharge. serologic studies of paired sera showed a rise in antibody to jamestown canyon virus, a member of the california serogroup (family bunyaviridae). specific ...19827149109
antibodies to the california group of arboviruses in the moose (alces alces americana clinton) population of nova scotia.moose (alces alces americana clinton) blood collected by hunters during the 1977 and 1978 hunting seasons was tested for california group antibodies. hemagglutination inhibition (hi) tests using snowshoe hare virus (ssh) as antigen yielded 37.02% hi-positive sera. neutralization tests showed reactors reactors (67.5% positive) to ssh and classified six reactors as jamestown canyon virus (jc). this study reports the first finding of jc in a moose population; it also provides the first evidence of ...19817317859
determination and comparative analysis of the small rna genomic sequences of california encephalitis, jamestown canyon, jerry slough, melao, keystone and trivittatus viruses (bunyaviridae, genus bunyavirus, california serogroup).the nucleotide sequences of the small (s) genomic rnas of six california (cal) serogroup bunyaviruses (bunyaviridae: genus bunyavirus) were determined. the s rnas of two california encephalitis virus strains, two jamestown canyon virus strains, jerry slough virus, melao virus, keystone virus and trivittatus virus contained the overlapping nucleocapsid (n) and non-structural (nss) protein open reading frames (orfs) as described previously for the s rnas of other cal serogroup viruses. all n prote ...19957897347
isolations of jamestown canyon virus (bunyaviridae: california serogroup) from mosquitoes (diptera: culicidae) in the western united states, 1990-1992.nearly 80,000 immature and adult mosquitoes in three genera were collected in high-elevation (> 1,000 m) areas of california (68,229), nevada (3,721), oregon (5,918), and washington (1,629) during 1990-1992 and tested for virus as adult males or females in 1,799 pools. collections comprised primarily alpine aedes in the aedes communis (de geer) group of the subgenus ochlerotatus. thirteen strains of jamestown canyon (jc) virus were recovered by plaque assay in vero cell culture from three member ...19937903698
isolation of jamestown canyon and snowshoe hare viruses (california serogroup) from aedes mosquitoes in western massachusetts.three isolates of jamestown canyon virus and one isolate of snowshoe hare virus (california serogroup) were obtained from adult aedes females collected in western massachusetts in 1982. jamestown canyon virus was isolated from aedes abserratus/punctor once, and from aedes intrudens twice. snowshoe hare virus was isolated from aedes stimulans group mosquitoes. la crosse encephalitis (lac) virus was not isolated from 1,552 adult aedes triseriatus, nor from 22,557 aedes triseriatus larvae. however, ...19938350066
arbovirus surveillance in northern colorado, 1987 and 1991.arbovirus surveillance was conducted during an epizootic of western equine encephalitis (wee) during 1987 and during a nonepizootic year, 1991, in the same area in northern colorado. mosquitoes were collected in larimer county, co, during weeks 33-37 (10 august to 7 september) in 1987 and during weeks 26-35 (24 june to 26 august) in 1991. in total, 13,099 mosquitoes in 694 pools collected during 1987 and 8,672 mosquitoes in 242 pools collected during 1991 were tested for virus. wee virus was iso ...19938433334
vector competence of alpine, central valley, and coastal mosquitoes (diptera: culicidae) from california for jamestown canyon virus.mosquitoes collected from alpine, central valley, and coastal habitats in california were evaluated for their vector competence for four strains of jamestown canyon (jc) virus. three of the viral strains examined were isolated from alpine aedes species collected in california, and one, the prototype jc virus, was isolated from culiseta inornata (williston) collected in colorado. alpine aedes tahoensis dyar, ae. cataphylla dyar, ae. hexodontus dyar, ae. increpitus dyar, ae. clivis lanzaro and eld ...19938459417
detecting bunyaviruses of the bunyamwera and california serogroups by a pcr technique.many bunyaviruses of the bunyamwera and california serogroups are medically important human pathogens. the development of an effective technique to detect the viruses by using molecular biologic tools, such as pcr, improves not only clinical diagnosis but also virologic surveillance of mosquito vectors in the field. in this study, we evaluated eight pairs of primers for reactivity with 44 viruses of the genus bunyavirus, using a reverse transcriptase pcr technique. with a pair of serogroup-speci ...19968727900
the s rna genomic sequences of inkoo, san angelo, serra do navio, south river and tahyna bunyaviruses.the complete nucleotide sequences of the small (s) genomic rna segments of five california (cal) serogroup bunyaviruses (two inkoo virus strains, san angelo virus, serra do navio virus, south river virus and tahyna virus) were determined. in agreement with previously published data concerning cal serogroup viruses, the nucleocapsid (n) and non-structural (nss) proteins were encoded in over-lapping open reading frames (orfs). all n protein orfs were 708 nucleotides in length and encoded a 235 ami ...19968760423
inkoo and tahyna, the european california serogroup bunyaviruses: sequence and phylogeny of the s rna segment.inkoo (ink) and tahyna (tah) viruses, european representatives of the california serogroup (cal), genus bunyavirus, family bunyaviridae, are transmitted by mosquitoes and frequently infect man. the s segments of ink and tah prototype strains were amplified, cloned and sequenced. ink s consists of 986 and tah s of 977 nucleotides (nt) coding for a nucleocapsid protein of 235 amino acids (aa) and, in an overlapping reading frame, for a nonstructural protein of 92 or 97 aa, respectively. by s segme ...19968760424
ecology of jamestown canyon virus (bunyaviridae: california serogroup) in coastal california.this paper reports the first isolation of jamestown canyon (jc) virus from coastal california and the results of tests for antibody to jc virus in mammals living in coastal california. the virus isolation was made from a pool of 50 aedes dorsalis females collected as adults from morro bay, san luis obispo county, california. the virus isolate was identified by two-way plaque reduction-serum dilution neutralization tests done in vero cell cultures. sera from the mammals were tested for antibody t ...19968780458
serologic evidence of jamestown canyon virus infection in white-tailed deer populations from connecticut.we determined the prevalence and distribution of jamestown canyon (jc) virus antibody in white-tailed deer (odocoileus virginianus) populations in connecticut, usa. sera were collected from hunter-killed deer during 1993. antibody to jc virus was detected by enzyme-linked immunosorbent assay (elisa) in 92 (21%) of 446 deer sera, and was uniformly distributed among geographic sites. twenty-one elisa-positive sera were tested and confirmed positive by plaque reduction neutralization testing. this ...19979249710
diagnosis of jamestown canyon encephalitis by polymerase chain reaction.in recent years, polymerase chain reaction (pcr) has been under study as a potential technique to improve the accuracy of diagnosis of suspected central nervous system viral infections. we describe a case of severe encephalitis in a previously healthy 20-year-old woman from new york who presented with headache, fever, and photophobia. her illness was characterized by progressive worsening of her neurological status, leading to confusion, delirium, and status epilepticus. the diagnosis of jamesto ...199910451169
isolation of jamestown canyon virus (california virus group) from vesicular lesions of a horse. 200010690785
serologic survey for selected infectious disease agents in swift and kit foxes from the western united states.a serologic survey of swift fox (vulpes velox) and kit fox (v. macrotis) from the western usa was conducted for 12 infectious diseases. samples from swift fox were collected between 1987 and 1992 from colorado (n = 44), kansas (n = 10), and wyoming (n = 9). samples from kit fox were collected in california (n = 86), new mexico (n = 18), utah (n = 9), and arizona (n = 6). overall antibody prevalence rates were 33 of 110 (30%) for canine parvovirus (cpv), 9 of 72 (13%) for canine distemper virus ( ...200011085448
arbovirus surveillance in south carolina, 1996-98.arboviruses isolated and identified from mosquitoes in south carolina (usa) are described, including new state records for eastern equine encephalitis virus (eee), st. louis encephalitis virus (sle), flanders virus, tensaw virus (ten), and a variant of jamestown canyon virus (jc). mosquitoes were collected at 52 locations in 30 of 46 south carolina counties beginning in june 1996, and ending in october 1998, and tested for arboviruses. of 1,329 mosquito pools tested by virus isolation (85,806 mo ...200111345423
jamestown canyon virus: seroprevalence in connecticut. 200111747714
temporal abundance, parity, survival rates, and arbovirus isolation of field-collected container-inhabiting mosquitoes in eastern tennessee.surveillance of container-inhabiting mosquitoes was conducted from june 17 through november 9, 1998, at 2 1997 la crosse virus (lac) human case sites (knox and cocke counties, tennessee). mosquitoes were collected weekly with 2 dry ice-baited centers for disease control miniature light traps, 2 omnidirectional fay traps, and 40 oviposition traps at each site. a total of 8,408 mosquitoes, composed of ochlerotatus triseriatus (n = 2,095) and aedes albopictus (n = 6,313), were reared or collected a ...200212322937
jc [corrected] virus detection in human tissue specimens.to clarify the advantages and disadvantages of different detection methods for jamestown canyon virus (jcv) in human tissue specimens.200717237186
progressive multifocal leukoencephalopathy in an aids patient.progressive multifocal leukoencephalopathy (pml) is a demyelinating brain disease caused by jamestown canyon virus (jcv). this disease is an important cause of morbidity and mortality in acquired immunodeficiency syndrome (aids) patients. we report a 34-year-old man infected with hiv-1 who presented with frequent general tonic clonic seizure and left side weakness for 2 months. clinical features and magnetic resonance imaging (mri) findings with hyperintensity on t2-weighted imaging and low dens ...200717493905
rna binding domain of jamestown canyon virus s segment rnas.jamestown canyon virus (jcv) is a member of the bunyaviridae family, orthobunyavirus genus, california serogroup. replication and, ultimately, assembly and packaging rely on the process of encapsidation. therefore, the ability of viral rnas (vrnas) (genomic and antigenomic) to interact with the nucleocapsid protein (n protein) and the location of this binding domain on the rnas are of interest. the questions to be addressed are the following. where is the binding domain located on both the vrna ...200717913826
[correlation between load of polyomavirus and hemorrhagic cystitis].to study the correlation between polyoma virus load and hemorrhagic cystitis after allogeneic stem cells transplantation for prevention of hemorrhagic cystitis.200717971934
genetic relationships of jamestown canyon virus strains infecting mosquitoes collected in connecticut.jamestown canyon virus (jcv) (family bunyaviridae, genus orthobunyavirus) is maintained in a mosquito-deer cycle and has been implicated in the etiology of meningitis and encephalitis with human cases reported from ontario, canada, michigan, connecticut, and new york. despite the recognition of symptomatic cases in the northeastern united states, little is known about the genetic relationships of jcv variants circulating in this region. accordingly, we compared the phylogenetic relationships of ...200718165540
isolations of jamestown canyon virus (bunyaviridae: orthobunyavirus) from field-collected mosquitoes (diptera: culicidae) in connecticut, usa: a ten-year analysis, 1997-2006.jamestown canyon virus (jcv) (bunyaviridae: orthobunyavirus) is a mosquito-borne zoonosis belonging to the california serogroup. it has a wide geographic distribution, occurring throughout much of temperate north america. white-tailed deer, odocoileus virginianus are the principal amplification hosts, and boreal aedes and ochlerotatus mosquitoes are the primary vectors. a 10-year study was undertaken to identify potential mosquito vectors in connecticut, quantify seasonal prevalence rates of inf ...200818386967
molecular identification of host feeding patterns of snow-melt mosquitoes (diptera: culicidae): potential implications for the transmission ecology of jamestown canyon virus.we collected blood-fed, snow-melt mosquitoes (culicidae: culiseta and aedes) to describe the feeding patterns of potential mosquito vectors of jamestown canyon virus (jcv, bunyaviridae: orthobunyavirus). jcv is an arthropod-borne, zoonotic virus with deer as the primary amplifying host in western alpine ecosystems. we collected mosquitoes from natural resting areas, fiber pots, and carbon-dioxide baited miniature light traps in the colorado rocky mountains in 2007. we conducted two polymerase ch ...201020380304
tahyna virus genetics, infectivity, and immunogenicity in mice and monkeys.tahyna virus (tahv) is a human pathogen of the california encephalitis virus (cev) serogroup (bunyaviridae) endemic to europe, asia, and africa. tahv maintains an enzootic life cycle with several species of mosquito vectors and hares, rabbits, hedgehogs, and rodents serving as small mammal amplifying hosts. human tahv infection occurs in summer and early fall with symptoms of fever, headache, malaise, conjunctivitis, pharyngitis, and nausea. tahv disease can progress to cns involvement, although ...201121435229
the full genome sequence of three strains of jamestown canyon virus and their pathogenesis in mice or monkeys.jamestown canyon virus (jcv), family bunyaviridae, is a mosquito-borne pathogen endemic in the united states and canada that can cause encephalitis in humans and is considered an emerging threat to public health. the virus is genetically similar to inkoo virus circulating in europe, suggesting that much of the northern hemisphere contains jcv or similar variants.201121435230
human jamestown canyon virus infection --- montana, 2009.jamestown canyon virus (jcv) is a mosquito-borne zoonotic pathogen belonging to the california serogroup of bunyaviruses. although jcv is widely distributed throughout temperate north america, reports of human jcv infection in the united states are rare. this is the first report of human jcv infection detected in montana, one of only 15 cases reported in the united states since 2004, when jcv became reportable. on may 26, 2009, a man aged 51 years with no travel history outside of montana went t ...201121617630
A Recombinant Chimeric La Crosse Virus Expressing the Surface Glycoproteins of Jamestown Canyon Virus Is Immunogenic and Protective against Challenge with either Parental Virus in Mice or Monkeys.La Crosse virus (LACV) and Jamestown Canyon virus (JCV), family Bunyaviridae, are mosquito-borne viruses that are endemic in North America and recognized as etiologic agents of encephalitis in humans. Both viruses belong to the California encephalitis virus serogroup, which causes 70 to 100 cases of encephalitis a year. As a first step in creating live attenuated viral vaccine candidates for this serogroup, we have generated a recombinant LACV expressing the attachment/fusion glycoproteins of JC ...201222013033
major emerging vector-borne zoonotic diseases of public health importance in canada.in canada, the emergence of vector-borne diseases may occur via international movement and subsequent establishment of vectors and pathogens, or via northward spread from endemic areas in the usa. re-emergence of endemic vector-borne diseases may occur due to climate-driven changes to their geographic range and ecology. lyme disease, west nile virus (wnv), and other vector-borne diseases were identified as priority emerging non-enteric zoonoses in canada in a prioritization exercise conducted by ...201526954882
zoonotic infections in communities of the james bay cree territory: an overview of seroprevalence.the cree communities of james bay are at risk for contracting infectious diseases transmitted by wildlife. data from serological testing for a range of zoonotic infections performed in the general population (six communities), or trappers and their spouses (one community), were abstracted from four population-based studies conducted in cree territory (quebec) between 2005 and 2009. evidence of exposure to trichinella species, toxoplasma gondii, toxocara canis, echinococcus granulosus, leptospira ...201324421806
arboviruses in north dakota, 2003-2006.to investigate arbovirus transmission in north dakota, we collected and screened mosquitoes for viral infection by vero cell culture assay. seven viruses were isolated from 13 mosquito species. spatial and temporal distributions of the important vectors of west nile virus (wnv), cache valley virus, jamestown canyon virus (jcv), and trivittatus virus are reported. snowshoe hare virus, potosi virus, and western equine encephalomyelitis virus were also isolated. the risks of culex tarsalis and aede ...201425487728
jamestown canyon virus disease in the united states-2000-2013.jamestown canyon virus (jcv) is a mosquito-borne orthobunyavirus in the california serogroup that can cause an acute febrile illness, meningitis, or meningoencephalitis. we describe epidemiologic and clinical features for jcv disease cases occurring in the united states during 2000-2013. a case of jcv disease was defined as an acute illness in a person with laboratory evidence of a recent jcv infection. during 2000-2013, we identified 31 cases of jcv disease in residents of 13 states. the median ...201526033022
four emerging arboviral diseases in north america: jamestown canyon, powassan, chikungunya, and zika virus diseases.arthropod-borne viruses, or arboviruses, are viruses that are transmitted through the bites of mosquitoes, ticks, or sandflies. there are numerous arboviruses throughout the world capable of causing human disease spanning different viral families and genera. recently, jamestown canyon, powassan, chikungunya, and zika viruses have emerged as increasingly important arboviruses that can cause human disease in north america. unfortunately, there are currently no proven disease-modifying therapies fo ...201626903031
roles of host species, geographic separation, and isolation in the seroprevalence of jamestown canyon and snowshoe hare viruses in newfoundland.california serogroup viruses, including jamestown canyon virus (jcv) and snowshoe hare virus (sshv), are mosquito-borne members of the bunyaviridae family and are endemic across north america. these arboviruses are potential pathogens which occasionally cause neuroinvasive disease in humans and livestock. a neutralization assay was used to document jcv and sshv seroprevalence using blood collected from a variety of domestic and wildlife host species. these species were sampled in an island setti ...201222798366
serological survey for antibodies to mosquito-borne bunyaviruses among us national park service and us forest service employees.serum samples from 295 employees of great smoky mountains national park (grsm), rocky mountain national park (romo), and grand teton national park with adjacent bridger-teton national forest (grte-btnf) were subjected to serological analysis for mosquito-borne bunyaviruses. the sera were analyzed for neutralizing antibodies against six orthobunyaviruses: la crosse virus (lacv), jamestown canyon virus (jcv), snowshoe hare virus (sshv), california encephalitis virus, and trivittatus virus (tvtv) b ...201626855300
the seasonal timing of snowshoe hare virus transmission on the island of newfoundland, canada.arthropod-borne diseases negatively affect humans worldwide. understanding the biology of the arthropod vectors and the pathogens they harbor, the arthropods are moving targets as a result of climate change, ecosystem degradation, species introductions, and increased human travel. viruses within the california serogroup of the genus orthobunyavirus (family bunyaviridae) are among the mosquito-borne viruses of concern owing to their zoonotic potential. two of these, snowshoe hare virus (sshv) and ...201728069630
west nile virus and other arboviral diseases--united states, 2012.arthropod-borne viruses (arboviruses) are transmitted to humans primarily through the bites of infected mosquitoes and ticks. west nile virus (wnv) is the leading cause of domestically acquired arboviral disease in the united states. however, several other arboviruses also cause sporadic cases and seasonal outbreaks of neuroinvasive disease (e.g., meningitis, encephalitis, and acute flaccid paralysis). in 2012, cdc received reports of 5,780 nationally notifiable arboviral disease cases (excludin ...201323803959
west nile virus and other nationally notifiable arboviral diseases - united states, 2014.arthropod-borne viruses (arboviruses) are transmitted to humans primarily through the bites of infected mosquitoes and ticks. west nile virus (wnv) is the leading cause of domestically acquired arboviral disease in the united states (1). however, several other arboviruses also cause sporadic cases and seasonal outbreaks. this report summarizes surveillance data reported to cdc in 2014 for wnv and other nationally notifiable arboviruses, excluding dengue. forty-two states and the district of colu ...201526334477
west nile virus and other arboviral diseases - united states, 2013.arthropod-borne viruses (arboviruses) are transmitted to humans primarily through the bites of infected mosquitoes and ticks. west nile virus (wnv) is the leading cause of domestically acquired arboviral disease in the united states. however, several other arboviruses also cause sporadic cases and seasonal outbreaks of neuroinvasive disease (i.e., meningitis, encephalitis, and acute flaccid paralysis). this report summarizes surveillance data reported to cdc in 2013 for wnv and other nationally ...201424941331
west nile virus disease and other arboviral diseases - united states, 2011.arthropodborne viruses (arboviruses) are transmitted to humans primarily through the bites of infected mosquitoes and ticks. symptomatic infections most often manifest as a systemic febrile illness and, less commonly, as neuroinvasive disease (e.g., meningitis, encephalitis, or acute flaccid paralysis). west nile virus (wnv) is the leading cause of domestically acquired arboviral disease in the united states. however, several other arboviruses also cause seasonal outbreaks and sporadic cases. in ...201222785342
california serogroup virus infection associated with encephalitis and cognitive decline, canada, 2015.california serogroup (csg) viruses, such as jamestown canyon and snowshoe hare viruses, are mosquitoborne pathogens that cause febrile illness and neurologic disease. human exposures have been described across canada, but infections are likely underdiagnosed. we describe a case of neuroinvasive illness in a new brunswick, canada, patient infected with a csg virus.201728726628
seasonal distribution, blood-feeding habits, and viruses of mosquitoes in an open-faced quarry in connecticut, 2010 and 2011.seasonal abundance of mosquitoes, their viruses, and blood-feeding habits were determined at an open-faced quarry in north branford, ct, in 2010 and 2011. this unique habitat had not previously been sampled for mosquitoes and mosquito-borne viruses. thirty species of mosquitoes were identified from 41,719 specimens collected. coquillettidia perturbans, aedes trivittatus, and ae. vexans were the most abundant species and represented 34.5%, 17.7%, and 14.8% of the totals, respectively. jamestown c ...201831442119
environmental conditions for jamestown canyon virus correlated with population-level resource selection by white-tailed deer in a suburban landscape.suburban landscapes can alter spatial patterns by white-tailed deer (odocoileus virginianus) and increase animal contact with vectors, pathogens, and humans. close-contact relationships at a landscape level can have broad implications for disease epidemiology. from 1995-1999, we captured and radio-collared 41 deer in two suburban forest preserves in chicago, illinois. we collected blood to determine if animals were seronegative or seropositive for jamestown canyon virus and tracked deer movement ...201931589661
differences in neuropathogenesis of encephalitic california serogroup viruses.the california serogroup of orthobunyaviruses comprises a group of mosquitoborne viruses, including la crosse (lacv), snowshoe hare (sshv), tahyna (tahv), jamestown canyon (jcv), and inkoo (inkv) viruses, that cause neurologic disease in humans of differing ages with varying incidences. to determine how the pathogenesis of these viruses differs, we compared their ability to induce disease in mice and replicate and induce cell death in vitro. in mice, lacv, tahv, and sshv induced neurologic disea ...201930882310
seroprevalence of jamestown canyon virus in the japanese general population.jamestown canyon virus (jcv) is a mosquito-borne orthobunyavirus that causes acute febrile illness, meningitis, and meningoencephalitis, mainly among adults. jcv is widely distributed in north america and the number of jcv cases in the u.s. has increased in recent years. therefore, the central nervous system disease caused by jcv can be considered a potentially re-emerging viral disease. however, the seroprevalence of jcv is unknown in japan. the purpose of this study is to evaluate the seroprev ...202033096994
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