| meningo-encephalitis in gnotobiotic pigs inoculated intransally and orally with porcine adenovirus 4. | | 1972 | 4339608 |
| cultivation of a porcine adenovirus in porcine thyroid cell cultures. | the porcine adenovirus type 4 was adapted to grow in porcine thyroid cell cultures. a readily recognizable cytopathic effect appeared in these cells as soon as the first passage of the virus and complete degeneration of the monolayers was obtained after only 72 hours post-infection at the fourth passage. a viral yield of 10(6.0) tcid50/ml was calculated after the third passage. the virus was purified by cscl density gradient centrifugation and was shown to possess a buoyant density of 1.33 g/ml. ... | 1984 | 6375960 |
| prevalence of antibodies to swine influenza virus, porcine adenovirus type 4 and haemophilus pleuropneumoniae in quebec pig farms with respiratory problems. | the prevalence of antibodies to three etiological agents involved in swine pneumonia was determined in quebec pig farms which had experienced problems of mild to severe respiratory problems. of the 350 sera collected from adults pigs, 67.0%, 18.3% and 46.6% had antibody titers to haemophilus pleuropneumoniae type 1 and/or 5, to porcine adenovirus type 4 and to swine influenza virus, respectively. comparatively, the serological prevalence rates for haemophilus pleuropneumoniae, porcine adenovirus ... | 1985 | 17422542 |
| crystallization of the head and galectin-like domains of porcine adenovirus isolate nadc-1 fibre. | the porcine adenovirus nadc-1 isolate, a strain of porcine adenovirus type 4, has a fibre with an atypical architecture. in addition to a classical virus attachment region, shaft and head domains, it contains an additional galectin like domain c-terminal to the head domain and connected to the head domain by a long rgd-containing loop. the galectin-like domain contains two putative carbohydrate-recognition domains. the head and galectin-like domains have been independently crystallized. diffract ... | 2009 | 19923738 |
| crystallographic structure of porcine adenovirus type 4 fiber head and galectin domains. | adenovirus isolate nadc-1, a strain of porcine adenovirus type 4, has a fiber containing an n-terminal virus attachment region, shaft and head domains, and a c-terminal galectin domain connected to the head by an rgd-containing sequence. the crystal structure of the head domain is similar to previously solved adenovirus fiber head domains, but specific residues for binding the coxsackievirus and adenovirus receptor (car), cd46, or sialic acid are not conserved. the structure of the galectin doma ... | 2010 | 20686025 |
| incorporation of porcine adenovirus 4 fiber protein enhances infectivity of adenovirus vector on dendritic cells: implications for immune-mediated cancer therapy. | one strategy in cancer immunotherapy is to capitalize on the key immunoregulatory and antigen presenting capabilities of dendritic cells (dcs). this approach is dependent on efficient delivery of tumor specific antigens to dcs, which subsequently induce an anti-tumor t-cell mediated immune response. human adenovirus serotype 5 (hadv5) has been used in human studies for gene delivery, but has limited infection in dcs, which lack the proper receptors. addition of the porcine fiber knob (pk) from p ... | 2015 | 25933160 |
| an adenovirus vector incorporating carbohydrate binding domains utilizes glycans for gene transfer. | vectors based on human adenovirus serotype 5 (hadv-5) continue to show promise as delivery vehicles for cancer gene therapy. nevertheless, it has become clear that therapeutic benefit is directly linked to tumor-specific vector localization, highlighting the need for tumor-targeted gene delivery. aberrant glycosylation of cell surface glycoproteins and glycolipids is a central feature of malignant transformation, and tumor-associated glycoforms are recognized as cancer biomarkers. on this basis, ... | 2013 | 23383334 |