| cutaneous inverted papillomas in dogs. | inverted papillomas of the skin occurred in five dogs. lesions were 1-2 cm, circumscribed, flask-like structures below the level of the surrounding normal skin. walls of the structures consisted of hyperplastic epidermis, forming thin papillary projections on thin fibrovascular stalks. cells in the stratum granulosum had clear cytoplasm, numerous keratohyalin-like granules of various sizes, and poorly defined intranuclear inclusions. these cells stained positively for papillomavirus group-specif ... | 1988 | 2830698 |
| cutaneous neoplasms in dogs associated with canine oral papillomavirus vaccine. | a spectrum of proliferative cutaneous lesions occurred in 12 dogs at the injection site of live canine oral papillomavirus (cop) vaccine, suggesting a viral etiology for the masses. lesions included epidermal hyperplasia, epidermal cysts, squamous papilloma, basal cell epithelioma, and squamous cell carcinoma. peroxidase-antiperoxidase staining of tumor sections revealed nuclei which stained for group-specific papillomavirus antigen in five of 12 masses. electron microscopic examination of tumor ... | 1987 | 2842917 |
| cloning and characterization of a canine oral papillomavirus. | a papillomavirus, isolated from oral papillomas in young beagles, was used to produce a live-virus vaccine. after the im use of this vaccine, some dogs developed squamous cell carcinomas at the inoculation site. the virus was isolated from the original vaccine and was cloned into pbr322. a detailed restriction map of the viral genome was generated. | 1986 | 3013052 |
| papillary squamous cell carcinoma in three young dogs. | papillary squamous cell carcinomas were located on the gingiva of 3 young dogs. the tumors locally invaded the soft tissues of each dog, and invaded bone in 2 dogs. surgical excision was unsuccessful in eliminating 2 of the tumors. surgery and radiotherapy were effective, and recurrence has not been observed in 39 months in 1 dog, 32 months in a second, and 10 months in a third. superficially, the oral masses resembled papillomas, which are known to be caused by viruses. cytopathologic indicatio ... | 1988 | 3366682 |
| partial characterization of a canine oral papillomavirus. | | 1980 | 6156540 |
| a formalin-inactivated vaccine protects against mucosal papillomavirus infection: a canine model. | a formalin-inactivated canine oral papilloma homogenate was used as a vaccine to prevent infection by the oncogenic, mucosotropic canine oral papillomavirus (copv) in beagle dogs. twenty-six dogs received 2 doses of phosphate-buffered saline intradermally and 99 dogs received 2 doses of the inactivated vaccine. one month after the second dose all dogs were challenged with infectious copv by scarification of the oral mucosa. all of the control dogs developed papillomas by 6-8 weeks after challeng ... | 1994 | 7734063 |
| cloning and sequencing of the l1 gene of canine oral papillomavirus. | canine oral papillomavirus (copv) dna was isolated from two different sources. one of these dnas was molecularly cloned and its physical map was determined. hybridization analyses using subgenomic fragments of bovine papillomavirus type 1 (bpv-1) and human papillomavirus type 16 (hpv16) as probes revealed that the cloned copv shared moderate homology within the e1 and l1 regions of bpv-1 and hpv16, whereas homology in other regions of bpv-1 and hpv16 was low. the putative l1 gene of copv was seq ... | 1994 | 8076829 |
| canine oral papillomavirus genomic sequence: a unique 1.5-kb intervening sequence between the e2 and l2 open reading frames. | the canine oral papillomavirus (copv) is associated with oropharyngeal papillomatosis in dogs, coyotes, and wolves. we have determined the complete nucleotide sequence of copv, the largest of all known pv genomes (8607 bp). the genomic architecture of the copv genome is similar to that of other pvs except for a unique and large noncoding region of 1.5 kb between the end of the early region (e2) and the beginning of the late region (l2) and a small (345 bp) upstream regulatory region between the ... | 1994 | 8091677 |
| involvement of canine oral papillomavirus in generalized oral and cutaneous verrucosis in a chinese shar pei dog. | severe papillomatosis developed in the oral cavity and spread throughout the haired skin of the trunk and limbs of an 8-month-old female chinese shar pei dog. the dog had received corticosteroids prior to referral, which was associated with the onset of demodecosis and papillomatosis. papillomavirus structural antigens were detected in biopsies by immunohistochemistry using a panel of monoclonal and polyclonal antibodies. an 8.2-kilobase papillomavirus-specific dna molecule was detected in the c ... | 1994 | 8203080 |
| systemic immunization with papillomavirus l1 protein completely prevents the development of viral mucosal papillomas. | infection of mucosal epithelium by papillomaviruses is responsible for the induction of genital and oral warts and plays a critical role in the development of human cervical and oropharyngeal cancer. we have employed a canine model to develop a systemic vaccine that completely protects against experimentally induced oral mucosal papillomas. the major capsid protein, l1, of canine oral papillomavirus (copv) was expressed in sf9 insect cells in native conformation. l1 protein, which self-assembled ... | 1995 | 8524802 |
| diagnosis and clinical course of canine oral papillomavirus infection. | a six-month-old intact male rottweiler presented with papillomatous growths protruding from the oral mucous membranes. a tentative diagnosis of canine oral papillomavirus (copv) infection was made based on the gross appearance of the numerous lesions and the young age of the patient. two warts from the oral mucosa were removed surgically for further diagnostic investigations. the viral aetiology of the diseases was confirmed by histopathological and electron microscopic findings, and by the iden ... | 1996 | 8683957 |
| detection of canine oral papillomavirus-dna in canine oral squamous cell carcinomas and p53 overexpressing skin papillomas of the dog using the polymerase chain reaction and non-radioactive in situ hybridization. | nineteen cutaneous and mucocutaneous papillomas, as well as 29 oral and 25 non-oral squamous cell carcinomas of dogs were analyzed immunohistologically for the presence of papillomavirus (pv)-antigens. canine oral papillomavirus (copv)-dna was detected in formalin-fixed, paraffin-embedded tissues by polymerase chain reaction (pcr) and non-radioactive in situ hybridization (ish). furthermore, the expression of the tumor suppressor protein p53 was investigated. pv-antigens were detectable in more ... | 1998 | 9646444 |
| mutant canine oral papillomavirus l1 capsid proteins which form virus-like particles but lack native conformational epitopes. | recently, the l1 capsid protein of canine oral papillomavirus (copv) has been used as an effective systemic vaccine that prevents viral infections of the oral mucosa. the efficacy of this vaccine is critically dependent upon native l1 conformation and, when purified from sf9 insect cells, the l1 protein not only displays type-specific, conformation-dependent epitopes but it also assembles spontaneously into virus-like particles (vlps). to determine whether vlp formation was coupled to the expres ... | 1998 | 9747722 |
| naturally occurring, nonregressing canine oral papillomavirus infection: host immunity, virus characterization, and experimental infection. | papillomaviruses occasionally cause severe, nonregressing or recurrent infections in their human and animal hosts. the mechanisms underlying these atypical infections are not known. canine oral papillomavirus (copv) typically regresses spontaneously and is an important model of mucosal human papillomavirus infections. a severe, naturally occurring, nonregressing copv infection provided an opportunity to investigate some aspects of viral pathogenicity and host immunity. in this case, the papillom ... | 1999 | 10600607 |
| spontaneously regressing oral papillomas induce systemic antibodies that neutralize canine oral papillomavirus. | canine oral papillomavirus (copv) infection of naive beagle dogs causes oral papillomas, most of which spontaneously regress. regressor beagles do not develop new oral papillomas because of copv type-specific, cell-mediated immunity, copv neutralizing antibodies, or both. formalin-fixed native and recombinant copv vaccines that target the systemic immune system induce neutralizing antibodies that prevent development of oral papillomas. this study was designed to determine whether spontaneously r ... | 2000 | 10816383 |
| molecular characteristics of cutaneous papillomavirus from the canine pigmented epidermal nevus. | to investigate the relation between the canine pigmented epidermal nevus (pen) and cutaneous papillomavirus, we cloned and sequenced the l1 gene of papillomavirus from the canine pigmented epidermal nevus (pen). amplification of dna sample with the l1 consensus primers yielded an expected fragment of approximately 450-bp. the nucleotide sequences of the fragment showed about 64% of sequence similarity to the l1 region of human papillomavirus isolate cp6108 and less than 57% sequence similarity t ... | 2000 | 11129863 |
| intra-epithelial vaccination with copv l1 dna by particle-mediated dna delivery protects against mucosal challenge with infectious copv in beagle dogs. | protection against viral challenge with canine oral papillomavirus (copv) was achieved by immunisation via particle-mediated dna delivery (pmdd) of a plasmid encoding the copv l1 gene to cutaneous and oral mucosal sites in beagle dogs. the initial dose of approximately 9 microg of dna was followed by two booster doses at 6 week intervals. a similar approach was used to vaccinate a control group of animals with plasmid dna encoding the hepatitis b virus s gene. following challenge at the oral muc ... | 2001 | 11282188 |
| regression of canine oral papillomas is associated with infiltration of cd4+ and cd8+ lymphocytes. | canine oral papillomavirus (copv) infection is used in vaccine development against mucosal papillomaviruses. the predictable, spontaneous regression of the papillomas makes this an attractive system for analysis of cellular immunity. immunohistochemical analysis of the timing and phenotype of immune cell infiltration revealed a marked influx of leukocytes during wart regression, including abundant cd4+ and cd8+ cells, with cd4+ cells being most numerous. comparison of these findings, and those o ... | 2001 | 11312659 |
| detection of viral dna and e4 protein in basal keratinocytes of experimental canine oral papillomavirus lesions. | we studied experimental canine oral papillomavirus (copv) infection by in situ hybridization and immunohistochemistry of weekly biopsies. after 4 weeks, viral dna in rete ridges suggested a keratinocyte stem cell target. abundant viral dna was seen in e4-positive cells only. e4 was predominantly cytoplasmic but also nuclear, being concentrated in the nucleoli during wart formation. infected cells spread laterally along the basal layer and into the parabasal layers, accompanied by e7 transcriptio ... | 2001 | 11352670 |
| immunization with a pentameric l1 fusion protein protects against papillomavirus infection. | the prophylactic papillomavirus vaccines currently in clinical trials are composed of viral l1 capsid protein that is synthesized in eukaryotic expression systems and purified in the form of virus-like particles (vlps). to evaluate whether vlps are necessary for effective vaccination, we expressed the l1 protein as a glutathione s-transferase (gst) fusion protein in escherichia coli and assayed its immunogenic activity in an established canine oral papillomavirus (copv) model that previously val ... | 2001 | 11483728 |
| absence of canine oral papillomavirus dna following prophylactic l1 particle-mediated immunotherapeutic delivery vaccination. | in the canine oral papillomavirus (copv) model, following wart regression, copv dna was detected by pcr at the challenge site. however, following particle-mediated immunotherapeutic delivery (pmid) of copv l1 and subsequent challenge, no copv dna could be detected. these data support pmid of copv l1 as a protective vaccine and suggest that pmid of l1 may induce virus clearance. | 2002 | 12185285 |
| felis domesticus papillomavirus, isolated from a skin lesion, is related to canine oral papillomavirus and contains a 1.3 kb non-coding region between the e2 and l2 open reading frames. | we have characterized the complete genome (8300 bp) of an isolate of felis domesticus papillomavirus (fdpv) from a domestic cat with cutaneous papillomatosis. a blast homology search using the nucleotide sequence of the l1 open reading frame demonstrated that the fdpv genome was most closely related to canine oral papillomavirus (copv). a 384 bp non-coding region (ncr) was found between the end of l1 and the beginning of e6, and a 1.3 kbp ncr was located between the end of e2 and the beginning o ... | 2002 | 12185286 |
| life cycle heterogeneity in animal models of human papillomavirus-associated disease. | animal papillomaviruses are widely used as models to study papillomavirus infection in humans despite differences in genome organization and tissue tropism. here, we have investigated the extent to which animal models of papillomavirus infection resemble human disease by comparing the life cycles of 10 different papillomavirus types. three phases in the life cycles of all viruses were apparent using antibodies that distinguish between early events, the onset of viral genome amplification, and th ... | 2002 | 12239317 |
| intraepithelial dna immunisation with a plasmid encoding a codon optimised copv e1 gene sequence, but not the wild-type gene sequence completely protects against mucosal challenge with infectious copv in beagles. | dna plasmids encoding the open reading frames of canine oral papillomavirus (copv) nonstructural early genes e1, e2, or e7 protein were delivered into both oral mucosal and cutaneous epithelial sites in beagle dogs using particle-mediated immunotherapeutic delivery (pmid) technology. control dogs were vaccinated with plasmid encoding either hepatitis b virus surface antigen (hbvs) or copv l1. using a prophylactic immunisation protocol, a priming dose of plasmid dna was followed by a booster dose ... | 2002 | 12504584 |
| therapeutic immunisation with copv early genes by epithelial dna delivery. | following challenge with copv (canine oral papillomavirus), dna plasmids encoding copv l1, e1 or e2 protein were delivered into oral mucosal and cutaneous sites in beagles using particle-mediated immunotherapeutic delivery (pmid). two weeks post-challenge, a priming dose of 8 microg dna was delivered followed by a booster dose after a further two weeks. a group of control dogs were vaccinated using plasmid dna encoding hepatitis b virus surface (hbvs) gene. all of the control animals developed w ... | 2003 | 14554090 |
| development of a canine model for recurrent respiratory papillomatosis. | a canine model for recurrent respiratory papillomatosis (rrp) was developed with canine oral papillomavirus (copv) inoculated into the buccal mucosa and supraglottic larynx of 5 beagles. the animals received systemic immunosuppression with daily oral prednisone at doses of 0, 1, 2, 3, and 4 mg/kg. buccal papillomata developed at 6 weeks in all animals and regressed by 10 weeks in the animals that received 0 and 1 mg/kg. the other animals had continuous growth of their buccal papillomata for 26 w ... | 2003 | 14703102 |
| characterization of hpv16 l1 loop domains in the formation of a type-specific, conformational epitope. | virus-like particles (vlps) formed by the human papillomavirus (hpv) l1 capsid protein are currently being tested in clinical trials as prophylactic vaccines against genital warts and cervical cancer. the efficacy of these vaccines is critically dependent upon l1 type-specific conformational epitopes. to investigate the molecular determinants of the hpv16 l1 conformational epitope recognized by monoclonal antibody 16a, we utilized a domain-swapping approach to generate a series of l1 proteins co ... | 2004 | 15260888 |
| the papillomavirus life cycle. | papillomaviruses infect epithelial cells, and depend on epithelial differentiation for completion of their life cycle. the expression of viral gene products is closely regulated as the infected basal cell migrates towards the epithelial surface. expression of e6 and e7 in the lower epithelial layers drives cells into s-phase, which creates an environment that is conducive for viral genome replication and cell proliferation. genome amplification, which is necessary for the production of infectiou ... | 2005 | 15753007 |
| protection of beagle dogs from mucosal challenge with canine oral papillomavirus by immunization with recombinant adenoviruses expressing codon-optimized early genes. | replication-deficient adenoviral (rad5) vaccines containing codon-optimized e1, e2, e4, and e7 genes of canine oral papillomavirus (copv) were tested singly or in combination to determine which vaccines could protect against mucosal challenge with copv. in three studies, groups of 4-6 beagle dogs were immunized subcutaneously (s.c.) with 10(11) rad5 at 8-10 weeks and 4-6 weeks prior to challenge with infectious copv particles at multiple oral mucosal sites. control dogs were immunized with equiv ... | 2005 | 15892962 |
| isolation and cloning of the raccoon (procyon lotor) papillomavirus type 1 by using degenerate papillomavirus-specific primers. | partial sequences of a novel papillomavirus were amplified from a cutaneous lesion biopsy of a raccoon (procyon lotor), by using pcr with degenerate papillomavirus-specific primers. the procyon lotor papillomavirus type 1 (plpv-1) dna was amplified with long template pcr in two overlapping fragments, together encompassing the entire genome, and the complete plpv-1 genomic sequence was determined. the plpv-1 genome consists of 8170 bp, and contains the typical papillomaviral open reading frames, ... | 2005 | 15958682 |
| evaluation of papillomaviruses associated with cyclosporine-induced hyperplastic verrucous lesions in dogs. | to determine whether cyclosporine a-induced hyperplastic skin lesions of dogs were associated with papillomavirus infections. | 2005 | 16273908 |
| dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo. | nearly all cervical cancers are etiologically attributable to human papillomavirus (hpv) infection and pharmaceutical treatments targeting hpv-infected cells would be of great medical benefit. because many neoplastic cells (including cervical cancer cells) overexpress the transferrin receptor to increase their iron uptake, we hypothesized that iron-dependent, antimalarial drugs such as artemisinin might prove useful in treating hpv-infected or transformed cells. we tested three different artemis ... | 2005 | 16322232 |
| hpv16 l1 capsid protein expressed from viable adenovirus recombinants elicits neutralizing antibody in mice. | immunization against human papillomavirus (hpv) infection promises to reduce the worldwide burden of cervical cancer. to evaluate the potential of live recombinant adenoviruses for induction of hpv infection-blocking immunity, we prepared viable adenovirus recombinants that express the hpv16 l1 gene from the adenovirus major late transcriptional unit. adenovirus-produced hpv16 l1 assembles into virus-like particles (vlps) in infected cells in culture. purified hpv16 vlps are recognized by hpv16 ... | 2007 | 16914239 |
| cell-mediated immune responses to copv early proteins. | cell-mediated immunity plays a key role in the regression of papillomavirus-induced warts and intra-epithelial lesions but the target antigens that induce this response are not clear. canine oral papillomavirus (copv) infection of the oral cavity in dogs is a well-characterized model of mucosal papillomavirus infection that permits analysis of the immune events during the infectious cycle. in this study we show that during the copv infectious cycle, systemic t cell responses to peptides of sever ... | 2006 | 16949120 |
| modified tobacco mosaic virus particles as scaffolds for display of protein antigens for vaccine applications. | display of peptides or proteins in an ordered, repetitive array, such as on the surface of a virus-like particle, is known to induce an enhanced immune response relative to vaccination with the "free" protein antigen. the coat protein of tobacco mosaic virus (tmv) can accommodate short peptide insertions into the primary sequence, but the display of larger protein moieties as genetic fusions to the capsid protein has not been possible. we employed a randomized library approach to introduce a rea ... | 2006 | 16466765 |
| amplicon-plus targeting technology (aptt) for rapid production of a highly unstable vaccine protein in tobacco plants. | high-level expression of transgenes is essential for cost-effective production of valuable pharmaceutical proteins in plants. however, transgenic proteins often accumulate in plants at low levels. low levels of protein accumulation can be caused by many factors including post-transcriptional gene silencing (ptgs) and/or rapid turnover of the transgenic proteins. we have developed an amplicon-plus targeting technology (aptt), by using novel combination of known techniques that appears to overcome ... | 2007 | 17221361 |
| detection of canine oral papillomavirus dna in conjunctival epithelial hyperplastic lesions of three dogs. | papillomavirus infections are responsible for plaques and papillomas in various locations on the skin and in mucous membranes. the aim of this report was to describe morphologic features of a viral pigmented conjunctival plaque and 2 conjunctival squamous papillomas in 3 dogs, and to investigate these lesions for the presence of papillomavirus dna by polymerase chain reaction (pcr), dna sequence analysis, and in situ hydridization (ish). histopathology revealed in all neoplasms various degrees o ... | 2009 | 19112112 |
| resolution of persistent oral papillomatosis in a dog after treatment with a recombinant canine oral papillomavirus vaccine. | this report describes a 16-month-old female, otherwise seemingly healthy, siberian husky dog with severe oral papillomatosis that did not regress spontaneously and was refractory to surgical treatment over a 6-month period. regression of the papillomas was achieved by administering a series of experimental vaccinations starting at the time of the last surgery. the vaccine consisted of systemically administered canine oral papillomavirus major coat protein l1 that has been shown to self-assemble ... | 2003 | 19379331 |
| canine inverted papillomas associated with dna of four different papillomaviruses. | inverted papillomas are uncommon papillomavirus (pv)-induced canine skin lesions. they consist of cup- to dome-shaped dermal nodules with a central pore filled with keratin. histologically they are characterized by endophytic projections of the epidermis extending into dermis. cytopathic effects of pvs infection include the presence of clumped keratohyalin granules, koilocytes and intranuclear inclusion bodies. different dna hybridization studies carried out with a canine oral papillomavirus (co ... | 2010 | 20042038 |
| characterization of canine oral papillomavirus by histopathological and genetic analysis in korea. | in august 2008, forty dogs out of 400 developed oral warts in a breeding farm in korea. canine oral papilloma infection is a common disease in dogs. however, there has been no report of an outbreak of canine oral papillomavirus (copv) in a group of dogs or in dog breeding farms in korea, and the genetic analysis of copv in korea has yet to be performed. this study diagnosed canine oral papilloma from the oral samples of these dogs based on histopathological examination and immunohistochemistry. ... | 2010 | 20195061 |
| nucleotide-sequence of a canine oral papillomavirus containing a long noncoding region. | the dna genome of a canine oral papillomavirus (copv) was completely sequenced and found to consist of 8607 base pairs, which were the longest of all known papillomaviruses (pvs). its organization was similar to that of other pvs except that it lacked early gene 5 (e5) and possessed a unique long noncoding region (l-ncr) between the end of the early genes and the beginning of the late genes. copv also possessed a short noncoding region (s-ncr) which contained a putative upper regulatory region ( ... | 1995 | 21552821 |
| a multimeric l2 vaccine for prevention of animal papillomavirus infections. | it is unclear what level of neutralizing antibody is sufficient to protect cattle from experimental bovine papillomavirus type 4 (bpv4) challenge. markedly lower, and often undetected, serum neutralizing antibody titers were associated with protection in cattle vaccinated with bpv4 l2 as compared to l1 vlp. we hypothesized that vaccination with concatemers of the n-terminal protective epitopes of l2 derived from multiple animal papillomavirus types would enhance the breadth and strength of immun ... | 2011 | 21920572 |
| oral papillomatosis caused by enhydra lutris papillomavirus 1 (elpv-1) in southern sea otters (enhydra lutris nereis) in california, usa. | the southern sea otter (enhydra lutris nereis) is a threatened marine sentinel. during postmortem investigations of stranded sea otters from 2004 to 2013 in california, us, papillomas were detected in the oral cavity of at least seven otters via necropsy and histopathology. next-generation sequencing of viral particles purified from a single papilloma revealed a novel papillomavirus, enhydra lutris papillomavirus 1 (elpv-1). the genome of elpv-1 was obtained, representing the first fully sequenc ... | 2015 | 25647597 |
| squamous papillomas of the conjunctiva in dogs: a condition not associated with papillomavirus infection. | papillomas of the conjunctival surface in people can be of viral or nonviral origin and are found in high association with human papillomavirus. canine conjunctival papillomas are seldom described, and published accounts have mostly been associated with canine oral papillomavirus infection. here, we describe conjunctival squamous papillomas that do not express papillomavirus proteins and compare them with papillomavirus-associated conjunctival papillomas. conjunctival squamous papillomas present ... | 2015 | 25352202 |
| complete genome sequences of two isolates of canis familiaris oral papillomavirus from south africa. | canis familiaris oral papillomavirus, formerly canine oral papillomavirus, is a causative agent of the self-resolving canine oral papillomatosis and was first described in 1994. this is the first report of two full-length genome sequences described in south africa and indicates the highly conserved nature of canis familiaris oral papillomavirus. | 2016 | 27932637 |
| tp53 expressing squamous cell carcinoma of the tonsil in a captive polar wolf (canis lupus arctos). | the gross and histopathologic findings for a primary tonsillar squamous cell carcinoma in a captive 11-yr-old male polar wolf (canis lupus arctos) are described. the carcinoma had metastasized to regional lymph nodes of the pharynx, the precardial mediastinum, and the lungs. tumor suppressor protein tp53 was detected by immunohistochemistry in the nuclei of poorly differentiated, cytokeratin-positive cells of the primary neoplasm and the metastases. canine oral papillomavirus dna was not detecta ... | 2005 | 17312781 |
| canine oral papillomavirus outbreak at a dog daycare facility. | this report describes an outbreak at a dog daycare facility where 13 of 52 dogs developed suspected canine papillomavirus (cpv) infection. based on contact tracing, subclinical cpv shedding was speculated. active surveillance, exclusion of animals with active or recent infection and cohort formation may have been effective in stopping the outbreak. | 2017 | 28698695 |
| lambdapapillomavirus 2 in a gray wolf ( canis lupus ) from minnesota with oral papillomatosis and sarcoptic mange. | oral papillomatosis was diagnosed in a gray wolf ( canis lupus ) with sarcoptic mange from minnesota, usa found dead in february 2015. intranuclear inclusion bodies were evident histologically, and papillomaviral antigens were confirmed using immunohistochemistry. sequencing of the l1 papillomavirus gene showed closest similarity to lambdapapillomavirus 2. | 2017 | 28475450 |
| viable adenovirus vaccine prototypes: high-level production of a papillomavirus capsid antigen from the major late transcriptional unit. | safe, effective, orally delivered, live adenovirus vaccines have been in use for three decades. recombinant derivatives of the live adenovirus vaccines may prove an economical alternative to current vaccines for a variety of diseases. to explore that possibility, we constructed a series of recombinants that express the major capsid protein (l1) of canine oral papillomavirus (copv), a model for mucosal human papillomavirus (hpv) infection. vaccination with virus-like particles (vlps) composed of ... | 2005 | 15767581 |
| cloning and genomic characterization of felis domesticus papillomavirus type 1. | a novel papillomavirus was cloned from hyperkeratotic cutaneous lesions of a persian domestic cat. the felis domesticus papillomavirus (fdpv-1) genome counts 8300 bp and has a typical genome structure with an early region (e1, e2, e4, e6, e7), a late region (l1, l2), and a noncoding upstream regulatory region (urr or ncr1) between the end of l1 and the beginning of e6. the fdpv-1 also shows an unusual second noncoding region (ncr2) of 1.3 kb, situated between the end of e2 and the beginning of l ... | 2002 | 12359433 |
| an epidermotropic canine papillomavirus with malignant potential contains an e5 gene and establishes a unique genus. | a novel canine papillomavirus, cfpv-2, was cloned from a footpad lesion of a golden retriever. unlike the known canine oral papillomavirus (copv), which has a double-stranded dna genome size of 8607 bps, the genome of cfpv-2 is 8101 bps. some of this size difference is due to an abbreviated early-late region (elr), which is 1200 bps shorter than that of copv. however, cfpv-2 has other differences from copv, including the presence of an e5 orf between the e2 gene and the elr and an enlarged e4 or ... | 2007 | 17034826 |