subchronic oral administration of acemannan in the rat and dog.acemannan is the usan-accepted name for long-chain polydispersed beta-(1,4)-acetylated polymannose with interspersed o-acetyl groups, with a mannose monomer/acetyl ratio of approximately 1:1. this complex polysaccharide is extracted from aloe vera (barbadensis miller); the technical material contains approximately 78% acemannan. technical grade acemannan was administered po to rats for 14 d at 5% of the diet and for 6 mo at up to 2,000 mg/kg/d, and to beagle dogs for 90 d at up to 1,500 mg/kg/d ...19921509675
effects of low molecular constituents from aloe vera gel on oxidative metabolism and cytotoxic and bactericidal activities of human traditional south-east asian medicine the therapeutic value of the parenchymous leaf-gel of aloe vera for inflammatory-based diseases is well-reputed. the aim of this study is to investigate at which level gel-constituents exert their activity. we show here that low -mr constituents of an aqueous gel-extract inhibit the release of reactive oxygen species (ros) by pma-stimulated human pmn. the compounds inhibit the ros-dependent extracellular effects of pmn such as lysis of red blood cells. th ...19902167880
aloe vera.we review the scientific literature regarding the aloe vera plant and its products. aloe vera is known to contain several pharmacologically active ingredients, including a carboxypeptidase that inactivates bradykinin in vitro, salicylates, and a substance(s) that inhibits thromboxane formation in vivo. scientific studies exist that support an antibacterial and antifungal effect for substance(s) in aloe vera. studies and case reports provide support for the use of aloe vera in the treatment of ra ...19883286692
aloe vera. a natural approach for treating wounds, edema, and pain in diabetes. 19883367289
two functionally and chemically distinct immunomodulatory compounds in the gel of aloe aqueous extract of aloe vera gel was analyzed guided by modulatory activity with regard to the in vitro activation of human complement and of human polymorphnuclear leucocytes (pmn). upon ultrafiltration a high (h-mr) and a low (l-mr) molecular mass fraction were obtained. pre-incubation of human pooled serum with the h-mr fraction resulted in a depletion of classical and alternative pathway complement activity. in contrast, only the l-mr fraction could inhibit the production of free oxygen r ...19882843719
aloe vera gel hindered wound healing of experimental second-degree burns: a quantitative controlled the present study, aloe vera gel (avg) was applied to experimental second-degree burns in guinea pigs, and its effects on epithelialization, wound contraction, newly formed granulation tissue, and regeneration of hair follicles was compared with that effected by 1% silver sulfadiazine cream (agsd). epithelialization (%mean +/- sem) on postburn day 8, 16, and 24 of the avg-treated wounds was 38.72% +/- 2.71%, 60.34% +/- 3.28%, and 92.46% +/- 2.26%, respectively, while that of the agsd-treated ...19883360818
the role of topical agents in the healing of full-thickness wounds.eight topical agents in current use were studied for their effects on wound contraction and rate of reepithelialization of full-thickness excisions using a porcine animal model. the following agents were applied daily for a period of 27 days: scarlet red ointment, benzoyl peroxide lotion, bacitracin ointment, silver sulfadiazine cream, aloe vera gel, tretinoin cream, capsaicin cream, and mupirocin ointment. the rate of reepithelialization was significantly enhanced by treatment with capsaicin, b ...19892509527
[protective effect of extracts from aloe vera l. var. chinensis (haw.) berg. on experimental hepatic lesions and a primary clinical study on the injection of in patients with hepatitis].the injection(10-15 ml/kg/d, ip x 4), total glycoside (125-225 mg/kg/d, ip x (3-4); 600 mg/kg/d, ig x 3) and crystal iii (120 mg/kg/d, ip x 4) of aloe vera var. chinensis were found to be effective in lowering the elevated sgpt induced by ccl4, thioacetamide and d-aminogalactose in mice or rats. it was also observed that these agents could protect hepatic cells from the ccl4-induced injury. when dogs were given in with aloe injection of 0.1 ml/kg/d x 180, no toxicity was noted. the total effecti ...19892635602
experimental use of aloe vera extract in clinical practice. 19751039210
experimental and clinical observations on frostbite.experimental ischemia by the classic frostbite rabbit ear model clearly defined the role of thromboxane as a mediator of progressive dermal ischemia in frostbite injuries. the therapeutic groups consisted of the antiprostanoids, methylprednisolone, and aspirin combined with anti-thromboxane agents aloe vera and methimazole, while the control group received no therapy. survival was measured by planimetry for all groups. no tissue survival was evident in the frostbite control group. methimazole tr ...19873631670
nitric oxide production by chicken macrophages activated by acemannan, a complex carbohydrate extracted from aloe vera.cultures of normal chicken spleen cells and hd11 line cells produce nitric oxide (no) in response to acemannan, a complex carbohydrate derived from the aloe vera plant. neither cell type produced detectable amounts of no in response to similar concentrations of yeast mannan, another complex carbohydrate. nitric oxide production was dose dependent and inhibitable by the nitric oxide synthase inhibitor ng-methyl-l-arginine. in addition, the production of no was inhibited by preincubation of acm wi ...19957558512
treatment of experimental frostbite with pentoxifylline and aloe vera compare the therapeutic effects of systemic pentoxifylline and topical aloe vera cream in the treatment of frostbite.19957772322
the preventive and therapeutic potential of the squalene-containing compound, roidex, on tumor promotion and regression.recent scientific evidence has shown free radicals or reactive oxygen species (ros) to play an important role in the initiation and progression of cancer. many radical scavengers have also been found to help reduce the attacks by these ros. interestingly, the ros scavengers that have been investigated are naturally occurring compounds such as vitamins c and e. roidex is a formulation of squalene, vitamin e, and aloe vera. it was our goal to investigate whether roidex was able to prevent the deve ...19968625289
antiinflammatory activity of extracts from aloe vera gel.we studied the effects of aqueous, chloroform, and ethanol extracts of aloe vera gel on carrageenan-induced edema in the rat paw, and neutrophil migration into the peritoneal cavity stimulated by carrageenan. we also studied the capacity of the aqueous extract to inhibit cyclooxygenase activity. the aqueous and chloroform extracts decreased the edema induced in the hind-paw and the number of neutrophils migrating into the peritoneal cavity, whereas the ethanol extract only decreased the number o ...19969121170
isozymes of superoxide dismutase from aloe vera.extracts from the parenchymatous leaf gel and the rind of the aloe vera plant (aloe barbadensis miller) were shown to contain seven electrophoretically-identifiable superoxide dismutases (sods). the chromatographic elution profiles and the migration of these bands on native polyacrylamide gel electrophoresis (page), for both the gel and rind, are quite similar. two of these seven activities are insensitive to cyanide treatment, suggesting that they are mangano-sods. the other five activities are ...19969030888
isolation and characterization of the glycoprotein fraction with a proliferation-promoting activity on human and hamster cells in vitro from aloe vera gel.fractions of leaf gel from aloe barbadensis mill. were prepared by gel permeation using deae sephadex a-25, sepharose 6b, and sephadex g-50 columns. these were then tested by in vitro assays for proliferation of human normal dermal and baby hamster kidney cells. the glycoprotein fraction promoted cell growth, while the neutral polysaccharide fraction did not show any growth stimulation. moreover, the polar-colored glycoprotein fraction strongly inhibited the in vitro assays. an active glycoprote ...19979063091
the effects of prednisolone, indomethacin, and aloe vera gel on tissue culture cells. 19695248724
aloesin up-regulates cyclin e/cdk2 kinase activity via inducing the protein levels of cyclin e, cdk2, and cdc25a in sk-hep-1 the present study, we show that aloesin, which is a low molecular weight ingredients present in aloe vera, stimulates the proliferation of cultured human hepatoma sk-hep-1 cells. the incorporation of [3h] thymidine into dna in the cell cultures was significantly increased at a dose of 10 microm aloesin. the aloesin-induced dna synthesis appears to require newly synthesized proteins because cycloheximide treatment blocked the dna synthesis evoked by this compound. we then examined whether this ...19979063568
enhancement of allo-responsiveness of human lymphocytes by acemannan (carrisyn).healing powers have been imputed as being a feature of the gel from the aloe vera plant for centuries. the recent isolation of the active ingredient, acemannan, has made testing of this drug important. since the drug appears to enhance monocyte function in other experiments, these studies were designed to test the capacity of acemannan to enhance immune response to alloantigen and to test whether the potential enhancement is a monocyte driven phenomenon. acemannan did not enhance lymphocyte resp ...19882975271
anti-inflammatory activity of aloe vera against a spectrum of irritants.the authors have evaluated the spectrum of anti-inflammatory activity of a. vera in a number of models of inflammation in the hind paw of the experimental rat induced by kaolin, carrageenan, albumin, dextran, gelatin, and mustard. croton oil was used in a topical model of inflammation to determine the oral activity and time-dependent dosing of a. vera. the authors found that a. vera was active in all models of inflammation. of the various irritants tested, a. vera was especially active against g ...19892746485
an overview of the topical management of wounds.wounds in animals are a common and frequent reason for seeking veterinary attention. the way in which wounds are managed affect the rate of healing, the time to return to normal function, the final cosmetic appearance, and hence the satisfaction of customers. the management of wounds depends on the stage of wound healing and can include irrigation, mechanical and chemical debridement, the use of antiseptics and antimicrobials, adherent and nonadherent dressings, and miscellaneous topical applica ...19979247688
aloe vera and burn wound healing. 19892727155
the role of thromboxane in experimental inadvertent intra-arterial drug injections.inadvertent intra-arterial injection of drugs produces a well-defined clinical syndrome whose pathophysiology remains unclear. this study was designed to determine the role of the inflammatory mediator, thromboxane, in intra-arterial drug injections. the rabbit ear model, as described by kinmonth and sheppard, was used. five of the experimental groups were treated with specific or nonspecific thromboxane blocking agents and two groups served as controls. immunohistochemical staining of the contr ...19873559078
aloe vera and wound healing. 19872438402
adverse reactions to vitamin e and aloe vera preparations after dermabrasion and chemical peel.three women and one man aged forty-one to sixty-five years experienced a severe burning sensation following the application of aloe vera or vitamin e preparations to a skin area that had been subjected to a chemical peel or dermabrasion. subsequently, a severe dermatitis occurred that required hospitalization of one patient and intravenous administration of steroids. the dermatitis abated very slowly in all patients: full recovery took three months or more. one patient resumed the use of vitamin ...19912022130
aloe vera, salicylic acid, and aspirin for burns. 19892909067
aloe vera as a biologically active vehicle for hydrocortisone acetate.aloe vera, as a biological vehicle for hydrocortisone 21-acetate, was tested topically and systemically against acute inflammation. systemically, the combination of a. vera and hydrocortisone produced a maximum 88.1% inhibition of edema. polymorphonuclear leukocyte infiltration was reduced 91.1%. the topical inhibition of edema peaked at 97%. the possibility that a. vera has significant potential as a biologically active vehicle for steroids is discussed.19911993971
aloe vera for burns. 19892909066
toxicologic evaluation of injectable acemannan in the mouse, rat and dog.acemannan, the usan-accepted name for long-chain polydispersed beta-(1,4)-acetylated polymannose with interspersed 0-acetyl groups with a mannose monomer/acetyl ratio of approximately 1:1 and extracted from aloe vera (barbadensis miller), was administered as a 1.0 mg/ml solution to mice, rats and dogs, either as single dose or repeated at 4-d intervals for 8 doses by iv or ip routes. no significant signs of intoxication and no deaths occurred in animals treated with the single injection of acema ...19921609484
activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from aloe vera gel.acemannan is the name given to the major carbohydrate fraction obtained from the gel of the aloe vera leaf. it has been claimed to have several important therapeutic properties including acceleration of wound healing, immune stimulation, anti-cancer and anti-viral effects. however, the biological mechanisms of these activities are unclear. because of this wide diversity of effects, it is believed that they may be exerted through pluripotent effector cells such as macrophages. the effects of acem ...19968956975
effect of the combination of aloe vera, nitroglycerin, and l-name on wound healing in the rat excisional model.many systemic and topical therapeutic agents such as growth hormone, platelet-derived growth factor (pdgf), fibroblast growth factor (fgf), epidermal growth factor (egf), and insulin-like growth factor (igf) have been used as vulnerary agents. however, the role of nitric oxide (no) as a wound-healing stimulant has been received with mixed reviews. no is a potent vasodilator that is thought to be an endothelium-dependent relaxing factor, and a regulator of blood pressure and regional blood flow. ...19979395704
traditional medicine in health care.the state of research on plants used in traditional medicine and its development in egypt is indicated by the number of scientific institutions devoted to this problem: universities, the national research centre, the desert institute and the horticulture department of the ministry of agriculture. moreover, the use of certain medicinal plants has been "industrialised', e.g., ammi visnaga, cymbopogon proximus, nigella sativa and aloe vera. other plants are under investigation: urginea maritima, ph ...19807464176
in vitro angiogenic activity of aloe vera gel on calf pulmonary artery endothelial (cpae) cells.angiogenic activity of aloe vera gel was investigated by in vitro assay. we obtained the most active fraction from dichloromethane extract of aloe vera gel by partitioning between hexane and 90% aqueous methanol. the most active fraction (f3) increased the proliferation of calf pulmonary artery endothelial (cpae) cells. in addition, f3 fraction induced cpae cells to invade type 1 collagen gel and form capillary-like tube through in vitro angiogenesis assay, and increased the invasion of cpae cel ...19989875441
influence of aloe vera on collagen turnover in healing of dermal wounds in rats.treatment of full-thickness wounds with a. vera, on rats resulted in increased biosynthesis of collagen and its degradation. a corresponding increase in the urinary excretion of hydroxyproline was also observed. elevated levels of lysyl oxidase also indicated increased crosslinking of newly synthesised collagen. the results suggest that a. vera influences the wound healing process by enhancing collagen turnover in the wound tissue.19989854430
antiinflammatory activity of muktashukti bhasma.muktashukti bhasma (msb), an ayurvedic compound, consisting of pearl, aloe vera and vinegar, inhibited acute and subacute inflammation in albino rats as induced by subplanter injection of carrageenan, histamine, 5-ht, nystatin and subcutaneous implant of cotton pellets. in all the test procedures the antiinflammatory response of 1000 mg/kg msb was comparable to the response observed with 300 mg/kg acetylsalicylic acid (asa). oral premedication with msb delayed castor oil-induced diarrhoea in rat ...199810356960
in vitro evaluation of complex carbohydrate denture adhesive formulations.acemannan, a complex mannose carbohydrate derived from the aloe vera plant, has an inherent stickiness/viscosity. prototype acemannan denture adhesive formulations were evaluated for ph changes, cytotoxicity to human gingival fibroblasts and adhesive strength in both dry and wet conditions.19989807143
comparative evaluation of aloe vera in the management of burn wounds in guinea experimental study was designed using hartley guinea pigs, who received full-thickness burns covering 3 percent of their body surface area by direct contact with a hot plate. a total of 40 animals were equally divided among four modalities of closed burn wound management as follows: group i: silver sulfadiazine (silvadine); group ii: aloe vera gel extract (carrington dermal wound gel); group iii: salicylic acid cream (aspirin); and group iv: plain gauze occlusive dressing only. the dressings ...19883340673
induction of apoptosis in human leukaemic cell lines k562, hl60 and u937 by diethylhexylphthalate isolated from aloe vera linne.we investigated the effect of diethylhexylphthalate (dehp) from aloe vera linne on the apoptosis of human leukaemic cell lines k562, hl60 and u937 to examine its pharmacological activity. at a level of 10 microg ml(-1) dehp a significant anti-leukaemic effect was observed for all three cell lines, as measured by clonogenic assay. after treatment with 10 microg ml(-1) dehp for 4 h, agarose gel electrophoresis and flow cytometric analysis confirmed the occurrence of apoptosis. these results indica ...200011007077
vitamin c and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat.the effects of vitamin c and aloe vera gel extract supplementation on induced hepatocarcinogenesis in male sprague-dawley rats (120-150 g) by diethylnitrosamine (den) and 2-acetylaminofluorene (aaf) was investigated. the severity of the carcinogenesis process was determined by measuring gamma-glutamyl transpeptidase (ggt) and the placental form of glutathione s-transferase (gstp) histochemically in situ and in plasma and liver fractions. in addition, plasma alkaline phosphatase (alp) and liver m ...19989834927
separation and some properties of aloe vera l. leaf pulp lectins.the separation and partial purification of two lectins from the leaf pulp of aloe vera l. (=barbadensis miller) is presented. the fraction showing haemagglutinating activity was precipitated at 50% ammonium sulphate concentration from the crude leaf pulp extract. the precipitate thus obtained, after dialysis, was applied to a hydroxylapatite column. stepwise elution resulted in two peaks showing haemagglutinating activity eluted with 5 mm (aloctin i) and 20 mm (aloctin ii) phosphate buffers. hae ...199910479759
aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal we report that aloe-emodin (ae), a hydroxyanthraquinone present in aloe vera leaves, has a specific in vitro and in vivo antineuroectodermal tumor activity. the growth of human neuroectodermal tumors is inhibited in mice with severe combined immunodeficiency without any appreciable toxic effects on the animals. the compound does not inhibit the proliferation of normal fibroblasts nor that of hemopoietic progenitor cells. the cytotoxicity mechanism consists of the induction of apoptosis, whe ...200010850417
in vivo macrophage activation in chickens with acemannan, a complex carbohydrate extracted from aloe vera.acemannan (acm 1), a beta-(1,4) -acetylated mannan isolated from aloe vera, can be used as an effective adjuvant in vaccination against some avian viral diseases. our results demonstrate a quick and lasting in vivo priming effect of acm 1 on macrophage response after intramuscular inoculation in chickens (500 microg per 2-month-old bird). in response to ifn-gamma in vitro, monocytes from acm 1-treated chickens exhibited a strong enhancement of no production from 3 to 9 days p.i., but a weaker ef ...200010708884
anti-leukaemic and anti-mutagenic effects of di(2-ethylhexyl)phthalate isolated from aloe vera linne.extracts of aloe vera linne have been found to exhibit cytotoxicity against human tumour cell lines. this study examines the anti-tumour effects of di(2-ethylhexyl)phthalate (dehp) isolated from aloe vera linne, in human and animal cell lines. its anti-mutagenic effects were examined using salmonella typhimurium ta98 and ta100 strains. growth inhibition was specifically exerted by dehp against three leukaemic cell lines at concentrations below 100 microg ml(-1). at 100 microg ml(-1) dehp, k562, ...200010864149
upregulation of phagocytosis and candidicidal activity of macrophages exposed to the immunostimulant acemannan.previous studies by these investigators have shown that mannosylated bovine serum albumin (m-bsa) enhances the respiratory burst (rb), phagocytosis, and killing of candida albicans by resident murine peritoneal macrophages (mo). upregulation of the above mo functions was associated with binding of m-bsa to the mo-mannose receptor. the present study was done to determine if the immunostimulant, acemannan prepared from aloe vera, could stimulate mo in a similar manner. resident peritoneal mo colle ...19979278177
influence of aloe vera on collagen characteristics in healing dermal wounds in rats.wound healing is a fundamental response to tissue injury that results in restoration of tissue integrity. this end is achieved mainly by the synthesis of the connective tissue matrix. collagen is the major protein of the extracellular matrix, and is the component which ultimately contributes to wound strength. in this work, we report the influence of aloe vera on the collagen content and its characteristics in a healing wound. it was observed that aloe vera increased the collagen content of the ...19989562243
characterization of aloeride, a new high-molecular-weight polysaccharide from aloe vera with potent immunostimulatory activity.we have characterized a new immunostimulatory polysaccharide called aloeride from commercial aloe vera (aloe barbadensis) juice. aloeride is between 4 and 7 million da, and its glycosyl components include glucose (37.2%), galactose (23.9%), mannose (19.5%), and arabinose (10.3%). at 0.5 microg/ml aloeride increased nf-kappa b directed luciferase expression in thp-1 human monocytic cells to levels 50% of those achieved by maximal concentrations (10 microg/ml) of lps. aloeride induced the expressi ...200111262067
photochemistry and phototoxicity of aloe emodin.photochemical pathways leading to the phototoxicity of the aloe vera constituent aloe emodin were studied. the results indicate a photochemical mechanism involving singlet oxygen to be the most likely pathway responsible for the observed phototoxicity. aloe emodin was found to efficiently generate singlet oxygen when irradiated with uv light (phidelta = 0.56 in acetonitrile). the survival of human skin fibroblast cells in the presence of aloe emodin was found to decrease upon irradiation with uv ...200212003123
immunochemical distinction of aloe vera, a. arborescens, and a. chinensis gels.verectin antiserum raised in white rabbits was immunoprecipitated with the aloe vera nondialysable fraction. analysis of the immunoprecipitation revealed that verectin accounted for about 1.25% of the total proteins in the nondialysable fraction of aloe vera gel. the verectin antibody showed differential immunoreactivities against nondialysable fractions of a. arborescens, a. chinensis, and a. vera: 1) an immunopreciptin line was formed against the fraction of a. vera, but not against those of a ...19989581527
the wound-healing effect of a glycoprotein fraction isolated from aloe vera.aloe vera has been used as a family medicine for promoting wound healing, but it is not known which component of the plant is effective for this purpose.200111703278
the therapeutic potential of aloe vera in tumor-bearing rats.aloe vera has been claimed to contain several important therapeutic properties, including anticancer effects. the effect of aloe vera administration was studied on a pleural tumor in rat. growth of yoshida ah-130 ascite hepatoma cells injected (2 x 10(5) in 0.1 ml) into pleura of male inbred fisher rats was evaluated at different times (7th and 14th days). data show that the use of aloe vera proved a therapeutic method, and that the present experimental model could be useful in the study of othe ...199810093794
complementary/alternative medicine in dermatology: evidence-assessed efficacy of two diseases and two treatments.the objective of this article is to provide a brief, but critical, overview of the evidence related to complementary/alternative medicine (cam) use, and to offer valid and useful information for dermatologists in clinical practice. systematic literature searches were conducted on these databases: medline, embase, the cochrane library, ciscom and amed (until october 2000). where appropriate, the evaluation of the published literature was based on systematic reviews and randomized controlled trial ...200212069640
therapeutic effects of aloe vera on cutaneous microcirculation and wound healing in second degree burn model in demonstrate the microcirculatory and wound healing effects of aloe vera on induced second degree burn wounds in rats.200010808702
cytotoxicity of a low molecular weight fraction from aloe vera (aloe barbadensis miller) gel.the cytotoxicity of a low mol. wt fraction (lmwf) obtained from aloe vera gel was determined by two different assays. firstly, exposure of monolayers of chicken fibroblasts to lmwf induced disruption of intercellular junctions and detachment of individual cells from the bottom of the flask, with formation of cell-free gaps in the monolayer. secondly, lmwf inhibited the production of reactive oxygen species by human polymorphonuclear leukocytes stimulated by zymosan, as followed by luminol-depend ...19979403965
distribution of verectin in aloe vera leaves and verectin contents in clonally regenerated plants and the commercial gel powders by immunochemical screening.verectin antiserum raised in white rabbits was immunochemically applied to examine verectin distribution in aloe vera leaves during growth and flowering seasons, and to quantify verectin in clonally regenerated plants and commercial a. vera gel products.200010763598
comparative study of the assay of artemia salina l. and the estimate of the medium lethal dose (ld50 value) in mice, to determine oral acute toxicity of plant extracts.artemia salina l. (artemiidae), the brine shrimp larva, is an invertebrate used in the alternative test to determine toxicity of chemical and natural products. in this study the medium lethal concentrations (lc50 value) of 20 plant extracts, aloe vera (l.) burm. f. (aloeaceae), artemisia absinthium l. (asteraceae); citrus aurantium l. (rutaceae); cymbopogon citratus (dc. ex nees) stapf (poaceae); datura stramonium l. (solanaceae); justicia pectoralis jacq. (acanthaceae); musa x paradisiaca l. (m ...200111695884
effect of aloe vera leaves on blood glucose level in type i and type ii diabetic rat models.aloe vera (l.) burm. fil. (= a. barbadensis miller) (liliaceae) is native to north africa and also cultivated in turkey. aloes have long been used all over the world for their various medicinal properties. in the past 15 years, there have been controversial reports on the hypoglycaemic activity of aloe species, probably due to differences in the parts of the plant used or to the model of diabetes chosen. in this study, separate experiments on three main groups of rats, namely, non-diabetic (nd), ...200111268118
influence of aloe vera on the healing of dermal wounds in diabetic rats.the positive influence of aloe vera, a tropical cactus, on the healing of full-thickness wounds in diabetic rats is reported. full-thickness excision/incision wounds were created on the back of rats, and treated either by topical application on the wound surface or by oral administration of the aloe vera gel to the rat. wound granulation tissues were removed on various days and the collagen, hexosamine, total protein and dna contents were determined, in addition to the rates of wound contraction ...19989507904
maryland man, virginia physician sentenced for illegally marketing aloe vera 'treatments'. 200212085811
influence of aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats.the influence of aloe vera (l.) burman f. on the glycosaminoglycan (gag) components of the matrix in a healing wound was studied. wound healing is a dynamic and complex sequence of events of which the major one is the synthesis of extracellular matrix components. the early stage of wound healing is characterized by the laying down of a provisional matrix, which is then followed by the formation of granulation tissue and synthesis of collagen and elastin. the provisional matrix or the ground subs ...19989507902
herbal therapy: what every facial plastic surgeon must know.herbal medicine (phytomedicine) uses remedies possessing significant pharmacological activity and, consequently, potential adverse effects and drug interactions. the explosion in sales of herbal therapies has brought many products to the marketplace that do not conform to the standards of safety and efficacy that physicians and patients expect. unfortunately, few surgeons question patients regarding their use of herbal medicines, and 70% of patients do not reveal their use of herbal medicines to ...200111368667
technical note: artificial vagina vs a vaginal collection vial for collecting semen from rams.the time required to train rams to an artificial vagina (av) makes collecting semen from large numbers of rams difficult. to manage this problem, we developed a glass, round-bottomed, 1.9-cm i.d. x 9.8-cm long vaginal collection vial (vcv). three experiments were conducted to determine whether the vcv affected 1) semen volume per collection, 2) percentage of motile spermatozoa, 3) forward progressive motility score before and after extension and after freezing and thawing, and 4) our ability to ...200111811448
angiogenic activity of beta-sitosterol in the ischaemia/reperfusion-damaged brain of mongolian gerbil.aloe vera continues to be used for wound healing as a folk medicine. we previously reported that a. vera gel has angiogenic activity. in this study, we report upon the isolation of an angiogenic component beta-sitosterol from a. vera and examination of its effect upon damaged blood vessels of the mongolian gerbil. in a chick embryo chorioallantoic membrane assay, beta-sitosterol was found to have an angiogenic effect. it enhanced new vessel formation in gerbil brains damaged by ischaemia/reperfu ...200211988857
radical scavenging glycoprotein inhibiting cyclooxygenase-2 and thromboxane a2 synthase from aloe vera active glycoprotein fraction containing 58 % protein was isolated from aloe vera gel by precipitation with 55 % ammonium sulfate followed by gel permeation using deae-sephacel a-25, sepharose 6b and sephadex g-50 columns in a yield of 3 x 10 -3 %. the glycoprotein fraction showed a single band corresponding to a subunit of verectin at the same position when stained with both coomassie brilliant blue and periodic acid-schiff reagents on 18 % sds-page. the molecular weight (14 kda) was confirme ...200312677534
use of herbal medicine by elderly hispanic and non-hispanic white determine the types and prevalence of herbal medicines used by hispanic and non-hispanic white individuals aged 65 years and older. secondary objectives were to compare herbal medicine use according to ethnicity, sex, age, socioeconomic status, and education level, and to determine patients' beliefs about herbal medicines. use of nonphysician health care providers such as acupuncturists and chiropractors also was assessed.200312680482
medicinal plants of india with anti-diabetic potential.since ancient times, plants have been an exemplary source of medicine. ayurveda and other indian literature mention the use of plants in treatment of various human ailments. india has about 45000 plant species and among them, several thousands have been claimed to possess medicinal properties. research conducted in last few decades on plants mentioned in ancient literature or used traditionally for diabetes have shown anti-diabetic property. the present paper reviews 45 such plants and their pro ...200212020931
relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice.relative importance of bacopa monnieri (200 mg/kg), aegle marmelos (1.00 g/kg) and aloe vera (125 mg/kg) leaf extracts in the regulation of thyroid hormone concentrations in male mice was investigated. while serum levels of both t(3) and t(4) were inhibited by a. vera, a. marmelos extract could decrease only t(3) concentration. on the other hand, t(4) concentration was increased by b. monnieri extract suggesting its thyroid-stimulating role. when the relative potency of each plant extract was ca ...200212065164
evaluation of the use of complementary and alternative medicine in the largest united states-mexico border evaluate the use of complementary and alternative medicine (cam) in the el paso, texas, region.200211837563
the influence of long-term aloe vera ingestion on age-related disease in male fischer 344 rats.the effects of long-term aloe vera ingestion on age-related diseases were investigated using male specific pathogen-free (spf) fischer 344 rats. experimental animals were divided into four groups: group a, the control rats fed a semi-synthetic diet without aloe vera; group b, rats fed a diet containing 1% freeze-dried aloe vera filet; group c, rats fed a diet containing 1% charcoal-processed, freeze-dried aloe vera filet; and group d, rats fed the control diet and given whole leaf charcoal-proce ...200212458471
[molecular biological study of aloe vera in the treatment of experimental allergic rhinitis in rat].to study the therapeutic mechanism of aloe vera in allergic rhinitis (ar).200212592663
acemannan purified from aloe vera induces phenotypic and functional maturation of immature dendritic cells.acemannan, a major carbohydrate fraction of aloe vera gel, has been known to have antiviral and antitumoral activities in vivo through activation of immune responses. the present study was set out to define the immunomodulatory activity of acemannan on dendritic cells (dcs), which are the most important accessory cells for the initiation of primary immune responses. immature dcs were generated from mouse bone marrow (bm) cells by culturing in a medium supplemented with gm-csf and il-4, and then ...200111460308
blood and tissue concentration of cesium after exposure to cesium chloride: a report of two cases.complementary alternative medicine therapies based on the use of cesium chloride preparations for the treatment of cancer and radiation poisoning, have generated therapeutic interest; but oral or intravenous administration of cesium chloride (cscl) to cancer patients as an alternative mode of cancer therapy have not been approved by the us food and drug administration (fda).200312958400
the protective and healing effects of a natural antioxidant formulation based on ubiquinol and aloe vera against dextran sulfate-induced ulcerative colitis in rats.oxygen/nitrogen reactive species (ros/rns) are currently implicated in the pathogenesis of ulcerative colitis, drawing attention on the potential prophylactic and healing properties of antioxidants, scavengers, chelators. we evaluated the possible protective/curative effects of a natural antioxidant preparation based on aloe vera and ubiquinol, against intestinal inflammation, lesions, and pathological alterations of the intestinal electrophysiological activity and motility, in a rat model of ds ...200314695941
in vitro susceptibilities of shigella flexneri and streptococcus pyogenes to inner gel of aloe barbadensis miller.aloe barbadensis miller (or aloe vera) has widespread use in health products, and despite numerous reports on the whole plant, little work has been performed on the inner gel, which has been used extensively in these products. this report describes the in vitro susceptibilities of two bacteria to this component.200312604556
systematic review of herbs and dietary supplements for glycemic control in conduct a systematic review of the published literature on the efficacy and safety of herbal therapies and vitamin/mineral supplements for glucose control in patients with diabetes.200312663610
inhibition of propionibacterium acnes-induced mediators of inflammation by indian herbs.propionibacterium acnes, an anaerobic pathogen, plays an important role in the pathogenesis of acne by inducing certain inflammatory mediators. these mediators include reactive oxygen species (ros) and pro-inflammatory cytokines. in the present study, ros, interleukin-8 (il-8) and tumor necrosis factor-alpha (tnf-alpha) were used as the major criteria for the evaluation of anti-inflammatory activity. to prove the anti-inflammatory effects of herbs, polymorphonuclear leukocytes (pmnl) and monocyt ...200312622461
effects of aloe vera on gap junctional intercellular communication and proliferation of human diabetic and nondiabetic skin evaluate the effects of aloe vera on gap junctional intercellular communication (gjic) and proliferation of human skin fibroblasts in the presence or absence of basic fibroblast growth factor (fgf-2).200314629848
bacteriostatic property of aloe vera. 196414252823
retardation of wound healing by silver sulfadiazine is reversed by aloe vera and nystatin.inhibition of wound contraction by topical anti microbial agents has been described. the purpose of this study was to further investigate that phenomenon and to explore the effect that other agents such as aloe vera might have on this process. full-thickness excised wounds were created on the dorsum of sprague-dawley rats under anaesthesia. the wounds were treated with topical agents three times daily for fourteen days, then observed until healed. groups were: saline control, placebo (aqueous cr ...200314636760
therapeutic use of selected increasing number of people in the united states are using herbs for health promotion and specific symptom management. herbs are used to initiate healing through synergistic responses unlike the specific properties of pharmaceuticals. anecdotal data comprise much of the popular information available about herbs. scientific studies of the efficacy and safety of herbs, although on the rise, are less available than other drug trials. clinicians need an appropriate knowledge base for dealing with ...200012119629
[anti-inflammatory constituents, aloesin and aloemannan in aloe species and effects of tanshinon vi in salvia miltiorrhiza on heart].cinnamoyl, p-coumaroyl, feruloyl, caffeoyl aloesin, and related compounds were isolated from aloe species. the antiinflammatory and antioxidative activities of these compounds were examined based on the structure-activity relationship. it was suggested that the bioactivities may link to acyl ester groups in aloesin, together with those of aloesin-related compounds. however, investigations using the contact hypersensitivity response indicated a preventive effect of aloesin on the uv-b-induced imm ...200312875235
patterns of carbon partitioning in leaves of crassulacean acid metabolism species during deacidification.carbohydrates stored during deacidification in the light were examined in 11 crassulacean acid metabolism (cam) species from widely separated taxa grown under uniform conditions. the hypothesis that nad(p) malic enzyme cam species store chloroplastic starch and glucans, and phosphoenolpyruvate carboxykinase species store extrachloroplastic sugars or polymers was disproved. of the six malic enzyme species examined, kalanchoe tubiflora, kalanchoe pinnata, kalanchoe daigremontiana, and vanilla plan ...199612226397
effects of aloe preparation on the histamine-induced gastric secretion in rats.the effects of aloe preparation containing 80% aloe gel on the gastric acid, pepsin and mucus secretion were evaluated in histamine-induced gastric fistula model in rats by comparison to the effects of placebo and fresh aloe gel. aloe preparation and placebo at a dose of 8 ml/kg inhibited gastric acid but stimulated pepsin secretory rates. on the other hand, fresh aloe gel at a dose of 6.4 ml/kg prolonged histamine stimulatory effects on the gastric acid secretion while it inhibited gastric peps ...200415013187
antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in aloe vera.antioxidant components in aloe vera were examined for lipid peroxidation using rat liver microsomal and mitochondrial enzymes. among the aloesin derivatives examined, isorabaichromone showed a potent antioxidative activity. the dpph radical and superoxide anion scavenging activities were determined. as one of the most potent components, isorabaichromone together with feruloylaloesin and p-coumaroylaloesin showed potent dpph radical and superoxide anion scavenging activities. electron spin resona ...200212451482
use of herbal therapies among midlife mexican women.the cultural traditions of mexican women living in the united states make it likely that some women promote their health and manage their symptoms using various herbal therapies, yet we know little about this phenomenon. the purpose of this study was to describe and compare midlife mexican women living in the u.s. who were or were not using herbal therapies with regard to the extent of their acculturation, beliefs about herbs, and factors associated with their utilization of health services. a c ...200112141849
evaluation of three ancillary treatments in the management of equine grass sickness.brotizolam, acetylcysteine and aloe vera gel were evaluated as ancillary treatments for 29 cases of equine grass sickness. none of the treatments had any significant beneficial effect on the survival of the horses. however, 11 of 13 horses with mild chronic grass sickness survived solely with intensive nursing care.200212403518
effects of aloe vera on leukocyte adhesion and tnf-alpha and il-6 levels in burn wounded rats.the effects of aloe vera on microcirculation and levels of tnf-alpha and il-6 were investigated in rats after inducing burn. seventy-two male wistar furth rats were equally divided into four groups as follow: controls (con), untreated burn-wound rats (burn), normal saline-treated burn-wound rats (burn-nss) and aloe vera-treated burn-wound rats (burn-aloe). the animals in each group were equally subdivided into three subgroups for the study on day 3, 7 and 14 post-burn. dorsal skinfold chamber pr ...200314724347
effectiveness of aloe vera on the antioxidant status of different tissues in irradiated rats.this study was performed to evaluate the role of aloe vera (aloe barbadensis miller) on the antioxidant status in different tissues of animals whole body exposed to 7 gy gamma radiations, delivered as a shot dose. aloe vera (leaf juice filtrate) was supplemented daily to rats (0.25 ml/kg body weight/day), by gavage, 5 days before irradiation and 10 days after irradiation. experimental investigations performed 3, 7 and 10 days after exposure to radiation showed that aloe vera treatment has signif ...200314703976
identification of optimal molecular size of modified aloe polysaccharides with maximum immunomodulatory activity.polysaccharides isolated from the gel of aloe species have been known to have diverse biological activities, including immunomodulatory and antitumor activities. the molecular size-immunomodulatory activity relationship of modified aloe polysaccharide (map) was examined in this study. crude map (g2e1) was prepared from the gel of aloe vera that was partially digested with cellulase. proteins in crude map were removed by passage through a deae-sephacel column, and then the protein-free map (g2e1d ...200515652758
of hemorrhagic shock, spherical cows and aloe vera.the central question explored in this commentary is whether the beneficial effects of an aloe vera derived drag-reducing polymer during hemorrhagic shock is due to its o2 radical scavenging properties or to changes in blood rheology.200415566601
anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro.oral aloe vera gel is widely used by patients with inflammatory bowel disease and is under therapeutic evaluation for this condition.200414987320
[antilipoxygenase activity and the trace elements content of aloe vera in relation to the therapeutical effect].aloe vera is a rich source of many natural-health-promoting substances. the results of contemporary research on animal models indicate that the extracts have an antiinflammatory property. in this work the results of some in vitro experiments are shown: determination of the inhibitory effect of the aloe vera extracts on the activity of partially purified lipoxygenase from the rat lung cytosol fraction, and quantitative determination of the trace elements presented in the extract (mn, fe, cu, zn) ...200515751795
survival in a rat model of lethal hemorrhagic shock is prolonged following resuscitation with a small volume of a solution containing a drag-reducing polymer derived from aloe vera.drag-reducing polymers (drp) increase tissue perfusion at constant driving pressure. we sought to evaluate the effects of small-volume resuscitation with a solution containing a drp in a rat model of hemorrhage. anesthetized rats were hemorrhaged at a constant rate over 25 min. in protocol a, total blood loss was 2.45 ml/100 g, whereas in protocol b, total blood loss was 3.15 ml/100 g. five minutes after hemorrhage, the animals were resuscitated with 7 ml/kg of either normal saline (ns) or ns co ...200415257088
the controversial telomeres of lily plants.the molecular structure of the exceptional telomeres of six plant species belonging to the order asparagales and two species of the order liliales was analyzed using southern blot and fluorescence in situ hybridization. three different situations were found, namely: i) in the two liliales species, tulipa australis (liliaceae) and merendera montana (colchicaceae), the chromosome ends display hybridization signals with oligonucleotides resembling telomere repeats of both plants (tttaggg)n and vert ...200515753570
effect of aloe vera leaf gel and pulp extracts on the liver in type-ii diabetic rat models.the aim of this work was to investigate the effects of aloe vera leaf pulp and gel extracts on the liver tissue of neonatal streptozotocin (n0stz)-induced type-ii diabetic rats. the diabetic rats were separated into four groups and each group was given the following samples by gavage, daily for 15 d: phosphate buffered saline (pbs; diabetic control), aloe leaf pulp extract, aloe leaf gel extract, glibenclamide. liver tissues were examined histologically. the markers of oxidative stress: glutathi ...200415133247
hypoglycemic effect of aloe vera gel on streptozotocin-induced diabetes in experimental the present study an attempt has been made to evaluate the presence of hypoglycemic activity in the alcoholic extract of aloe vera gel. effects of oral administration of a. vera extract at a concentration of 200 and 300 mg/kg of body weight on (a) normal fasted rats, (b) oral glucose-loaded rats, and (c) streptozotocin-induced diabetic rats have been studied. a. vera extract maintain the glucose homeostasis by controlling the carbohydrate metabolizing enzymes.200415117555
the prevalence and predictors of herbal medicine use in surgical patients.despite the rapid rise in herbal medicine consumption, explicitly eliciting and documenting herbal medicine usage among surgical patients is poor.200415051013
effect of aloe vera (l.) burm. fil. leaf gel and pulp extracts on kidney in type-ii diabetic rat models.significant degenerative changes were observed in the kidney tissue of untreated neonatal streptozotocin (n0stz)-induced type-ii diabetic rats. these degenerative changes were diminished in the kidney tissue of diabetic animals given glibenclamide and aloe leaf gel and pulp extracts. kidney lipid peroxidation levels were increased in diabetic rats compared to healthy rats; these levels were higher in rats treated with glibenclamide than in those which received aloe extracts. serum urea and creat ...200415274480
do aloe vera and ageratum conyzoides enhance the anti-microbial activity of traditional medicinal soft soaps (osedudu)?the nigerian traditional soft soaps prepared using varied locally sourced raw materials such as cocoa pod ash (theobroma cacao) palm kernel shaft ash (elaies guineensis) have been evaluated for their physico-chemical properties and anti-microbial activities using standard pharmacopoeia protocols and an in-vitro agar diffusion bioassay method. the anti-microbial evaluation was done with and without incorporation of aloe vera and ageratum conyzoides extractives into the soap samples. results showe ...200415099848
efficacy of dietary aloe vera supplementation on hepatic cholesterol and oxidative status in aged the current study, we show the anti-oxidative and hypocholesterol effects of aloe vera in the liver. male specific pathogen-free (spf) fischer 344 rats were randomly assigned to one of four groups: group a (control) was fed test chow without aloe supplementation; group b was fed a diet containing a 1% (per weight basis) freeze-dried aloe filet; group c was fed a diet containing a 1% (per weight basis) charcoal-processed, freeze-dried aloe filet; and group d was fed a diet containing a charcoa ...200314598919
immunomodulatory and antimicrobial effects of some traditional chinese medicinal herbs: a review.the current practice of ingesting phytochemicals to support the immune system or to fight infections is based on centuries-old tradition. we review reports on seven chinese herbs, (aloe vera mill. (aloaceae), angelica species (umbelliferae), astragalus membranaceus bunge. (leguminosae), ganoderma lucidum (fr.) karst. (ganodermataceae), panax ginseng c.a mey. (araliaceae), scutellaria species (lamiaceae) and zingiber officinale rosc. (zingiberaceae) with emphasis to their immunomodulatory and ant ...200415180575
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