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effect of acid ph, salts, and temperature on the infectivity and physical integrity of enteroviruses.at 2 degrees and 30 degrees c, enteroviruses are more stable on the acid than on the alkaline side of neutrality. in the range from ph 3 to 9, temperature is so influential that the fastest inactivation rate at 2 degrees c is slower than the slowest inactivation rate at 30 degrees c. specific ions or salts also affect the rate of inactivation of enteroviruses. nacl and other chloride salts enhance the inactivation of poliovirus at ph 3. nacl is considerably less effective against poliovirus in t ...197613766
selective inhibiton of uncoating of echovirus 12 by rhodanine. a study on early virus-cell interactions. 197716383
inactivation of enteroviruses by ascorbic acid and sodium bisulfite.poliovirus type 1, coxsackievirus type a9, and echovirus type 7 were inactivated by sodium bisulfite and ascorbic acid. inactivation rates depended upon concentration, temperature, and ph. rna infectivity was lost during inactivation; the capsid was also altered by these inactivating agents, as determined by enzyme sensitivity assays and by tests of adsorption to cells. structural modifications of the virus particles were not identical, suggesting that the mechanism of inactivation by ascorbic a ...197829558
development of quantitative methods for the detection of enteroviruses in sewage sludges during activation and following land disposal.the development and evaluation of methods for the quantitative recovery of enteroviruses from sewage sludge are reported. activated sewage sludge solids were collected by centrifugation, and elution of the solid-associated virus was accomplished by mechanical agitation in glycine buffer at ph 11.0. eluted viruses were concentrated either onto an aluminum hydroxide floc or by association with a floc which formed de novo upon adjustment of the glycine eluate to ph 3.5. viruses which remained in th ...197829559
partial reactivation of chlorine-treated echovirus.after treatment of a dispersed suspension of echovirus with hocl, much of the lost plaque titer was restored if the treated virus was induced to aggregate by adjustment of the suspending medium to ph 4.5. this did not appear to be a repair of individual virions but rather a special kind of multiplicity-related increase in plaquing efficiency which occurred when the host cell received several of the damaged virions in a clump.197936850
influence of ph, salinity, and organic matter on the adsorption of enteric viruses to estuarine sediment.this study was designed to determine the degree of adsorption of enteric viruses to marine sediment and factors controlling this association. adsorption and elution characteristics of several enteroviruses and one rotavirus to estuarine sediments were studied under varying conditions of ph, salinity, and presence of soluble organics. greater than 99% of the added poliovirus type 1 (lsc), coxsackievirus type b3 (nancy), echovirus type 7 (wallace), and rotavirus (sa-11) adsorbed to sediment. echov ...197939508
comparative adsorption of human enteroviruses, simian rotavirus, and selected bacteriophages to soils.virus adsorption to soils is considered to be the most important factor in removing viruses after land treatment of wastewater. most of the studies on virus adsorption to soils have utilized poliovirus as the model system. in the present study, comparative adsorption of a number of different types and strains of human enteroviruses and bacteriophages to nine different soil types was studied. under the experimental conditions of this study, greater than 90% of all viruses adsorbed to a sandy loam ...197942350
fatal echo 30 virus infection and amyloidosis in x-linked hypogammaglobulinemia. 197545851
fatal echovirus 11 infections in outbreak in special-care baby unit.in december, 1977, an outbreak of echovirus 11 infection occurred in the special-care baby unit of the cambridge maternity hospital. 3 neonates died, and of 24 infants on the ward during the epidemic 6 others were infected, 3 with symptoms. 3 infants had similar symptoms but virus could not be isolated. the pathological changes in the 3 fatal infections, have not previously been reported for echovirus 11; nor have fatal infections occurred in an epidemic in a special-care baby unit.197880644
echovirus-11 infection in a special-care baby unit. 197984141
echovirus 11 infection and intrauterine death. 197984142
virucidal effect of alcohols against echovirus 11. 197985084
beta-hydroxy-beta-methylglutaricaciduria, reye's syndrome, and echovirus 11. 197986872
[echovirus encephalitis during bruton disease. favorable development. therapeutic problems].a 16 year old boy with bruton type agammaglobulinaemia developed acute encephalitis. echo virus type 3 was isolated on two occasions from the same sample of csf. clinical improvement occured after treatment with gammaglobulin with high anti-echo virus titers given intramuscularly and intrathecally. however the c.s.f. protein is still raised so that it is not certain he has been completely cured.197993470
effect of specific antibodies on chronic echovirus type 5 encephalitis in a patient with hypogammaglobulinemia.the effects of specific antibodies in chronic echovirus type 5 (echo 5) encephalitis were investigated in a patient with x-linked hypogammaglobulinemia. virus was detected in cerebrospinal fluid (csf) and blood despite treatment with commercial human gammaglobulin that contained low titers of antibodies to echo 5 (0.6 x 10(4) units per injection). virus disappeared from blood and csf when plasma containing high concentrations of antibodies (total dose, 1--4 x 10(4) units/kg) was administered int ...197994337
the relative effectiveness of commonly used disinfectants in inactivation of echovirus 11.echovirus 11 in the presence of fetal calf serum was exposed to six commonly used disinfectants for times of 10, 20 and 30 s. at the end of such exposure times, skim milk neutralized disinfectant activity and residual virus was assayed using the plaque technique. the six disinfectants studied were javex, sodium hydroxide, ethanol, wescodyne, one stroke ves-phene, and sonacide. although 0.25% (w/v) sodium hydroxide and 95% (v/v) ethanol were equally virucidal and significantly more so than the ot ...197899474
early processes of echovirus 12-infection: elution, penetration, and uncoating under the influence of rhodanine. 1979112773
[distribution of enteroviruses other than polioviruses in the csr in 1969-1973 (author's transl)]. 1976132281
an outbreak of aseptic meningitis in the area of fort smith, arkansas, 1975, due to echovirus type 4. 1977142759
arthralgias and arthritis in viral infections.arthritis and arthralgias are common in many viral infections. they are particularly prominent with hepatitis b virus and rubella infection, where they may be the major presenting symptom. "lyme arthritis" is also associated with a virus. similar symptoms are occasionally seen with adenovirus, coxsackie and echovirus infection. joint lesions are due to the deposition of immune complexes and not direct viral infection. while the arthritis is usually transient and self-limited, the physician must ...1978146421
virus development in enucleate cells: echovirus, poliovirus, pseudorabies virus, reovirus, respiratory syncytial virus and semliki forest virus.a group of rna viruses, echovirus, poliovirus, reovirus, respiratory syncytial virus and semliki forest virus have been examined for ability to grow in enucleate african green monkey kidney (bsci) cells. semliki forest virus produced an almost normal yield of virus but poliovirus, echovirus, reovirus and respiratory syncytial virus, although showing clear evidence of virus replication when compared with a nuclear dna virus (pseudorabies virus) gave much lower yields than those from nucleate cell ...1975163289
organ culture of human aorta: prolonged survival with support of viral replication.organ cultures were established with use of human fetal aorta obtained after death; cellular elements were preserved in the cultures for periods of up to eight weeks, with maintenance of their in vivo tissue relationships. histologically, these cultures preserve the three coats of the aorta, including an intact endothelial layer cells. the aorta organ cultures supported the replication of echovirus 11, herpes simplex virus type 1, adenovirus 2, and coxsackievirus b5 without the production of det ...1975165246
serologic characterization and sero-epidemiologic studies on acute hemorrhagic conjunctivitis (ahc) virus.serologic and sero-epidemiologic characteristics of ahc virus infection were studied by neutralization test (nt). four-fold or greater virus neutralizing (vn) antibody response was demonstrated to the japanese isolate of ahc virus (the j 670/71 strain) in 77.3% and 66.7% of paired sera from clinical ahc patients in japan (1971-1973) and tunisia (1973). the four patients from indonesia studied in 1972 showed similar antibody response. cross-neutralization tests of ahc virus isolated in japan (197 ...1975165719
[persistence of latex-agglutination inhibiting and neutralizing antibodies against enterovirus in the healthy population (author's transl)].sera of 122 persons were examined by the neutralization and latex-agglutination inhibition tests for antibodies against polio type i, coxsackie virus type a 9 and b 4, as well as echo virus type 9. with increasing age there was a titre difference between latex-agglutination inhibiting and neutralizing antibodies, due to the earlier fall in the former. these antibodies, contrary to neutralizing ones, were in the lower titre region. the results confirmed the usefulness of the latex-agglutination i ...1975169112
removal of enteroviruses from sewage by bench-scale rotary-tube trickling filters.the efficacy of a rotary-tube type of trickling filter for removing coxsackievirus a9, poliovirus 1, and echovirus 12 suspended in raw settled sewage was investigated. at filtration rates equivalent to about 10 mgd (million gallons per day)/acre (ca. 3,785 m3/day per acre), the filters removed 95% of the poliovirus, 83% of echovirus 12, and 94% of coxsackievirus a9. coliform, fecal streptococci, biochemical oxygen demand, and chemical oxygen demand removals were remarkably similar, averaging 94, ...1975169731
[effect of sodium salicylate on the "in vitro" development of rna viruses (author's transl)].sodium salicylate 10(-3) m is able to limit the number of plaques induced by rna viruses on monkey kidney cell cultures (cercopithecus aethiops and macaccus rhesus). however, the inhibition rate changes with the virus type or even the strain used. poliovirus 2, coxsackie b3, echovirus and reovirus 1 were the most susceptible to the inhibitory effect of the drug. latent infection caused by sv5 decreases the antiviral activity of salicylate. the stages of the poliovirus type 2 growth affected by s ...1975171988
studies on the survival and fate of enteroviruses in an experimental model of a municipal solid waste landfill and leachate.in laboratory scale municipal solid waste lysimeters containing simulated refuse, and seeded with either laboratory or field strains of poliovirus type 1 and echovirus type 7, viruses were not detected in the lysimeter leachate produced over a 4-month period. in addition, viruses were detected in the lysimeter refuse contents after termination of lysimeter operation. these results appeared to be due to virus retention in the lysimeter caused by virus adsorption and virus inactivation. evidence f ...1975172012
[respiratory tract infections of viral origin in infants. examination of 103 serum pairs in autumn and following spring].in autumn 1973 und about four months later in spring 1974 blood samples were taken from the same 103 children aged from a few months to five years and coming from different parts of bavaria. we examined the samples for complement-fixing antibodies against the influenza virus types a, b and c, the parainfluenza virus types 1, 2 and 3, the adenoviruses and the respiratory-syncytial virus, and for neutralising antibodies against the echo virus type 25. at the commencement of the investigation the m ...1975172769
[permissivity of mouse-man hybrid cell clones to three enteroviruses: poliovirus ii, coxsackie b3 and echovirus 11. role of human chromosome f. 19 (author's transl)].the permissivity of human cells to enteroviruses is linked to the presence of specific cell receptors. owing to the chance elimination of human chromosomes, the man-mouse hybrid cells may be permissive or not depending on the genome responsible for synthesis of the receptors, and whether it has been conserved or not. by comparison of the cytopathogenic effects and virus production after inoculation of the viruses polio ii, echo 11 and coxsachie b3 to various hybrid strains, we observed an identi ...1976180477
[is the acute infantile diarrhea often of viral etiology after all?]. 1976183902
[is there any morphological evidence of the viral etiology of endemic (balkan) nephropathy (author's transl)]. 1976184359
stability of human enteroviruses in estuarine and marine waters.studies of the effects of temperature and salinity on the survival of three enteric viruses (poliomyelitis type 1, echovirus-6, and coxsackievirus b-5) under controlled laboratory conditions and in situ indicate that temperature rather than salinity is the critical factor affecting their stability, in that the higher the temperature the more rapid was the loss of viral infectivity. in the laboratory studies, all three viruses were quite stable at 4 degrees c, with infectious virus still detectab ...1976184736
serologic comparison of hepatitis a antigen to echovirus 25 isolate cr69(076) recovered from a patient with viral hepatitis.a serologic comparison was performed by immune electron microscopy between hepatitis a antigen (related to the ms-1 strain of hepatitis a virus) and a viral isolate, cr69(076), from the stool of a patient in costa rica with viral hepatitis. cr69(076) was not antigenically related to hepatitis a antigen but was related to echovirus 25. thus, it is unrelated to the ms-1 strain of hepatitis a virus.1975186440
detection of virus in water: sensitivity of the tentative standard method for drinking water.the sensitivity of several microporous virus-adsorbent media for reliably detecting low levels of poliovirus from 380 and 1,900 liters of drinking water by use of the tentative standard method was investigated. the virus-adsorbent media tested were (i) nitrocellulose membrane filters, (ii) epoxy-fiber glass-asbestos filters, (iii) yarn-wound fiber glass depth filters, and (iv) epoxy-fiber glass filter tubes. virus was adsorbed to the filter media at ph 3.5 and eluted with glycine buffer, ph 11.5 ...1976187116
di george syndrome associated with glioma and two kinds of viral infection. 1977193003
enteroviruses other than poliovirus.the role of enteroviruses in certain specific disease--cardiac disease, nephritis, diabetes, and hemorrhagic conjunctivitis--is examined. it has now been well documented that coxsackievirus b (types cb1 through cb5 but not cb6) is the main pathogen involved in various clinical forms of viral heart disease. coxsackievirus a (ca4 and ca16) and echovirus (types 9 and 22) may also be associated with viral heart disease. in regard to the etiologic role of enteroviruses in nephritis, pancreatitis, and ...1976193602
recent advances in viral gastroenteritis. 1977193758
echovirus 12-induced host cell shutoff is prevented by rhodanine. 1977194165
specific restriction endonuclease degradation of dna as a consequence of immunologically mediated cell damage. 1977194374
distubed neuromuscular transmission in viral infections.14 subjects with influenza or echovirus infection, all suffering myalgia, and 9 subjects with mumps, in whom this symptom was lacking, were investigated with single fibre electromyography (emg) in the acute phase and during convalescence to reveal a possible disturbance in neuromuscular transmission. in both groups about the same percentage of the potential pairs studied showed abnormal transmission characteristics in the acute phase. two weeks after the acute infection, this percentage had decr ...1977197596
[clinical and immunopathological studies of viral nephritis]. 1977199763
nuclear abnormalities in muscle regenerating after echo 9 virus infection in mice. 1978203663
[clinical picture and spontaneous nitroblue tetrazolium reduction test in serious meningitis caused by enteroviruses]. 1977203890
aggregation of enterovirus small plaque variants and polioviruses under low ionic strength conditions.virion aggregation in low ionic conditions was observed with small plaque variants of coxsackievirus type b3 and echovirus types 4 and 11 by sedimentation and filtration methods. inclusion of salts or deae-dextran into the media prevented or reversed virion aggregation. the effect of ph on aggregate formation in low ionic strength solutions was also investigated with various strains of poliovirus. type i sabin strain formed aggregates even at high ph, while mahoney strains did so only below ph 6 ...1978204734
picorna- and togavirus infection of cells detected by gas chromatography.viral infection of cells causes chemical and metabolic changes, which can be detected by gas chromatography (gc) of ether extracts of supernatant fluids and cell homogenates before any significant damage to the cells is observable microscopically. the characteristic and specific gc patterns obtained from bhk-21 and vero cell cultures infected with encephalomyocarditis, polio, echoviruses, and a togavirus make it possible to distinguish between these infecting viruses. the appearance of 1 or 2 co ...1977204744
antiviral effects of amphotericin b methyl ester.the methyl ester of amphotericin b (ame) is water soluble, retains antifungal activity, and is significantly less toxic in mammals than amphotericin b. in contrast to amphotericin b, which is not water soluble, ame exhibits antiviral effects against vesicular stomatitis virus, herpes simplex virus types 1 and 2, sindbis virus, and vaccinia virus in a plaque reduction assay. no antiviral effects could be demonstrated against the unenveloped adenovirus type 4 or echovirus type 11. the extent of vi ...1978206201
role of sediment in the persistence of enteroviruses in the estuarine environment.the survival of four enteroviruses commonly found in sewage effluents was examined when the viruses were adsorped to marine sediments in estuarine water and compared with virus survival in estuarine water alone. echovirus 1, coxsackieviruses b3 and a9, and poliovirus 1 survived longer when associated with marine sediment. when the estuarine water was polluted with secondarily treated sewage effluent, virus survived for prolonged periods in sediments, but not in the overlaying estuarine water.1978206204
intranuclear crystal formation in picornavirus-infected cells.cells infected with echovirus or poliovirus were incubated at a suboptimal temperature (28 degrees c). when the cells were examined by electron microscopy, not only were crystalline arrays of mature virus particles observed in the cytoplasm but crystals composed of immature virus-like particles were also evident in the less electron-dense central region of the nucleus. immunofluorescent and autoradiographic studies revealed the presence of viral proteins and rna in the nucleus. these findings st ...1978208486
countercurrent immunoelectrophoresis in the diagnosis of viral infections of the central nervous system.countercurrent immunoelectrophoresis was utilized in the study of 621 specimens of cerebrospinal fluid to determine the correlation of detection of viral antigens with the clinical diagnosis of aseptic meningitis and related viral infections. a panel of viral antisera was immunoelectrophoresed against 119 specimens from patients with suspected viral infections of the central nervous system (group i), 32 from patients with bacterial meningitis (group 2), and 470 from patients with no suspected in ...1978216755
neutralization of aggregated strains of enterovirus 71 and echovirus type 4 in rd and vero or gmk-ah1 cells.strains of enterovirus 71 and echovirus type 4 containing aggregates which were poorly neutralized by antibody in cell lines of green monkey kidney origin such as vero and gmk-ah1, were as easily neutralized as non-aggregated strains when grown in human rd cells, the explanation for this may be a lesser degree of aggregation of viral materials originating from rd cells and/or the use of lower doses of virus for neutralization tests in such cells. the latter was a consequence of a higher sensitiv ...1979219662
non-polio enterovirus activity in wisconsin based on a 20-year experience in a diagnostic virology laboratory.laboratory test results, demographic information, and clinical data on 1364 patients who had specimens submitted to the wisconsin state laboratory of hygiene and from whom non-polio enteroviruses were isolated during 1957--1976 were examined. echoviruses (echo) and coxsackievirus group b (cb) and group a (ca) were isolated from 719, 389, and 256 of the patients, respectively. thirty-five different serotypes were identified in the 20-year period. the six most frequently occurring serotypes (echo ...1979222136
counterimmunoelectrophoresis test for immunoglobulin m antibodies to group b coxsackievirus.a counterimmunoelectrophoresis test was developed for immunoglobulin m (igm) antibodies to group b coxsackievirus (cb) types 1 through 5. the igm precipitin line could be identified and differentiated from the igg line by treating sera with 2-mercaptoethanol. antigen purity was demonstrated by single precipitin lines occurring only to the homologous antigen when tested with type-specific hyperimmune rabbit sera. serum pairs from 19 of 22 patients with documented cb type 1,3,4, and 5 infections w ...1979222806
[2 cases of meningoneuraxitis caused by enteroviruses]. 1978223506
[neurologic manifestations of mycoplasma infections]. 1979224312
infantile gastroenteritis caused by rotavirus: comparison of enzyme-linked immunosorbent assay and electron microscopy for rapid diagnosis.elisa and negative contrast em have used for the detection of rotavirus in one hundred stools from children, less than two years old, hospitalized for acute gastro-enteritis during the winter 1977-78. samples obtained from the same children some months after hospitalization were also tested. a good correlation was found between the results given by em and elisa, but the later technique turned out to be more sensitive (12% more positive using elisa). a rotavirus infection could be demonstrated in ...1979226197
factors involved in enzyme-linked immunoassay of viruses and evaluation of the method for identification of enteroviruses.a quantitative enzyme-linked immunosorbent assay was used for identification of selected enteroviruses: poliovirus type 1, echovirus type 6, coxsackievirus a type 9, and coxsackievirus b types 1 through 6. partially purified viral antigens or virus-specific antibodies were adsorbed to polystyrene spectrophotometer cuvettes, which permitted the assays to be reported and compared in terms of enzyme units specifically reacting. both the adsorbed antigen and the adsorbed antibody methods were approx ...1979229122
[enteroviruses (author's transl)]. 1979230470
virus detection in soils: a comparison of four recovery methods.among nine eluents tested, 0.5% (w/v) isoelectric casein at ph 9.0 and 0.5% (w/v) non-fat dry milk (ph 9.0) were the most efficient in eluting poliovirus type 1 (sabin) from eustis fine sand. however, no significant difference was found between the overall (elution followed by concentration) virus recoveries by non-fat dry milk, isoelectric casein, beef extract, and glycine-edta methods. high overall recovery (75%) of low input (200 pfu) of viruses from 100 g of soil was achieved by the isoelect ...1979230890
a study of infections and illnesses in a day nursery based on inclusion-bearing cells in the urine and infectious agent in faeces, urine and nasal secretion.during an epidemic-free period of nearly 2 years infections and illnesses were followed in a group of small children (2-3 1/2 years) in a day nursery. the incidence of illness was fairly low, 6.3 per child and year. the viral infections were followed by means of the inclusion reaction in the urine and isolation of virus, and the bacterial by culture of nasal secretion. in 60% of the cases the viral infection was accompanied by illness. in 57 cases of illness there were 27 (47%) with merely virus ...1979231298
enterovirus diseases with neurological determinations in adults. clinical and virological study.enteroviruses--4 polio, 30 coxsackie and 20 echovirus strains--were isolated from 54 patients with neurologic disease. in 29 cases (53.7%) viruses were isolated from the csf, blood clot and nerve tissue homogenates. the correlation of the complex clinical data and the localisation of the lesions in the cns demonstrate the involvement of cranial nerves, of the long bulbar motor pyramidal and extra-pyramidal tracts, of the reticular formation, a.o. these aspects are in accordance with the localisa ...1979231861
adsorption of enteroviruses to soil cores and their subsequent elution by artificial rainwater.the adsorption and elution of a variety of human enteroviruses in a highly permeable, sandy soil was studied by using cores (43 by 125 mm) collected from an operating recharge basin on long island. viruses studied included field and reference strains of polioviruses types 1 and 3 and reference strains of coxsackie virus b3 and echovirus types 1 and 6. viruses suspended in treated sewage effluent were allowed to percolate through soil cores, and the filtrate was assayed for unadsorbed viruses. to ...1979231936
[enteroviruses in cases of lymphocytic meningitis in warsaw during 1963-1976]. 1979232284
infections in neonatal units: prevention is better than cure. 1979261762
post-infectious encephalopathy simulating functional psychosis.three cases of post-infectious encephalopathy are presented in which behaviour changes occurred in the absence of neurological abnormality during convalescence from an influenza-like illness. the symptoms included aggresive behaviour, sleep reversal, sexual disinbition and a catatonic schizophrenia-like state. the prognosis was good.1977266660
echovirus 19 outbreak in auckland 1975-76.an epidemic of echovirus 19 infection in auckland, new zealand, during the summer of 1975-76 is reported. echovirus 19 was recovered from 33 patients, 70 percent of whom had upper respiratory tract involvement, 55 percent presented with meningitis and 33 percent exhibited a rash. gastroenteritis was diagnosed in 9 percent. various clinical syndrome combinations were common. the overall male to female ratio was one. infants younger than six months were more seriously affected than older patients.1977272534
echo virus 19 outbreak 1975-76. 1977272565
persistent and fatal central-nervous-system echovirus infections in patients with agammaglobulinemia.we observed persistent echovirus infection of the central nervous system, as defined by continued presence of isolatable virus in cerebrospinal fluid, in five patients with agammaglobulinemia. the immunologic deficit in each was characterized by absence of surface-immunoglobulin-bearing b lymphocytes and of lymph-node cortical follicles, but normal t-cell function. echoviruses 30, 19, 9 and 33 were recovered from cerebrospinal fluid for periods varying from two months to three years. the patient ...1977301244
[t-lymphocytes and b-lymphocytes in meningitis caused by echo-9 enteroviruses]. 1977302939
[b and t lymphocytes in peripheral blood of children with infections caused by echovirus 9]. 1977304572
enteroviral infections. 1978340797
airborne enteric bacteria and viruses from spray irrigation with wastewater.the relationship between bacterial concentrations in wastewater used for spray irrigation and in the air was examined. aerosolized coliforms were detected when their concentration was 10(3)/ml or more in the wastewater. relative humidity and solar irradiation appeared to affect viable bacteria in the air; a positive correlation was found between relative humidity and the number of aerosolized bacteria. the correlation between solar irradiation and bacterial level, on the other hand, was negative ...1978345967
coxsackievirus aggregates in muscle cells of a polymyositis patient.muscle biopsy specimens of a patient with polymyositis showed crystalline structures resembling picornavirus aggregates within muscle cells. the patient's serum reacted in an indirect immunofluorescence assay with autologous muscle cells. a strongly positive immunofluorescence staining was also noted when a section of muscle tissue was reacted with coxsackievirus a9 antiserum, and a weakly positive reaction was noted with coxsackievirus b2 antiserum. no staining was observed after treatment with ...1978352989
enteroviruses in human disease. 1978360295
viral infections and diseases of the heart. 1978360296
zoster-like eruption due to echovirus 6.a unilateral vesiculobullous eruption associated with fever was seen on the neck, shoulder, and upper part of the chest of a 7-year-old boy. although three dermatomes in all were involved, the lesions resembled herpes zoster. the patient had had varicella in infancy. culture of fluid from several bullae yielded echovirus 6; however, and serum neutralizing antibody to this virus rose in titer from 1:32 to 1:640. it is suggested that echovirus 6 and other enteroviruses may cause a number of vesicu ...1979371385
[echo-11 virus infection in a 6-month-old infant showing clinical signs of varicella]. 1979424258
[clinical course of serous meningitis associated with echo virus infection]. 1979432013
the relative resistance of f2 bacteriophage to inactivation by disinfectants.f2 bacteriophage in the presence of fetal calf serum (at a final concentration of 10%) was exposed to six commonly used disinfectants for times of 10, 20 and 30 sec. at the end of exposure times skim milk neutralized the disinfectant activity and residual virus was assayed using the plaque technique. the 6 disinfectants considered were javex, sodium hydroxide, ethanol, wescodyne, one stroke ves-phene and sonacide. a 0.25% (w/v) solution of sodium hydroxide and 1/50 javex (1200 parts/10(6) chlori ...1979458139
echovirus 33 replication in human peripheral white blood cells.echovirus 33 isolated from the cerebrospinal fluid of a patient with agammaglobulinemia was shown to replicate in vitro in peripheral leukocyte suspensions from a normal antibody negative donor. replication was demonstrated by use of sequential dilution experiments. washed glass adherent mononuclear cell cultures from a normal antibody negative donor were also capable of supporting echovirus 33 replication in vitro. leukocyte suspensions from the infected agammaglobulinemic patient extinguished ...1979479862
non-polio enterovirus disease in the united states, 1971--1975.reports to the center for disease control on isolation of non-polio enteroviruses for the years 1971--1975 were analysed. during the 5 year period, enterovirus isolations were reported from 7 075 individuals. 90% of these occurred in the 7 month interval of may--november. enteroviruses were isolated more frequently from males than females for all age groups in all 5 years. the incidence of reported isolations decreased with increasing age, and an inverse relationship between severity of disease ...1979489224
isolation and characterization of temperature-sensitive mutants of echovirus 12. 1979516450
acute infectious lymphocytosis with echo virus type 25. 1979532139
echo 25 focal encephalitis and subacute hemichorea.echo virus 25 focal encephalitis was documented for the first time in a 5-year-old boy with unequivocal hemichorea. hemichorea caused by enterovirus cns disease has never been reported. echo virus antigen in cerebrospinal fluid (csf) cells was demonstrated by the indirect immunofluorescent technique and typed by a significant rise in neutralizing antibodies against echo virus 25. sequential computerized tomographic (ct) studies with digital analysis demonstrated the evolution of a focal process ...1979571566
chronic echo type 5 virus meningoencephalitis in x-linked hypogammaglobulinemia: treatment with immune plasma.a patient with x-linked hypogammaglobulinemia developed chronic meningoencephalitis. echo virus type 5 was repeatedly cultured from cerebrospinal fluid (csf). infusions of high-titer, specific plasma resulted in clinical improvement, but failed to eradicate the virus. after more intensive plasma infusions, the virus could not be cultured from the csf. the patient died 8 months after institution of intensive therapy. the cause of death was unknown. autopsy showed persistence of perivascular and m ...1979572004
mesangiolytic glomerulonephritis in an infant with immune deficiency and echovirus infection.an unusual glomerulonephritis characterized by diffuse mesangial cell necrosis and lysis of mesangial areas was observed in a male infant who had a combined immune deficiency and systemic echovirus type 6 infection. the occurrence of glomerular disease in a patient with combined immune deficiency indicates that the glomerular injury can be inflicted without mediation of immune mechanisms, presumably by direct cytopathic effect of echovirus 6.1977576574
[aseptic meningitis in croatia caused by coxsackie and echo viruses (author's transl)]. 1977593048
[encephalomyelitis of atypical course probably caused by echovirus 7].the authors report a cases of encephalomyelytis caused probably by echo7 virus which was isolated from the cerebrospinal fluid after 45 days of disease. during 120 days 4 relapses of the disease were observed associated with severe general and neurological signs and cerebral coma which ultimately was the cause of death.1977593511
vesicular lesions in adults due to echovirus 11 infections.echovirus 11 was recovered from vesicular lesions in two adults. patient 1 had a severe disseminated vesicular exanthem. patient 2 had a mild vesicular enanthem. both were clinically suspected of having herpesvirus hominis lesions. serologic studies indicate that these viruses were similar to each other and also to the "u" prime strain.1977596902
[studies of an epidemic episode of serous meningitis caused by echo-virus 30].the authors report an outbreak of echo 30 aseptic meningitis occurred in marche and umbria countries from november 1975 to june 1976. the clinic, epidemiologic characteristics and the serological and virological results of 28 cases are discussed.1977597392
echovirus type 19 outbreak in northern ireland during 1974-75. 1977601924
enterovirus associated sporadic cases and epidemics. 1977603265
[epidemiological studies after an outbreak of meningitis (author's transl)].the outbreak of meningitis during the period from the end of august to the beginning of october 1974 in kiel affected 45 children, particularly those in the age group between 4 and 9 years. an potential causative agents echo viri were identified in 15/45 cases and coxsackie b viri in 2/45 cases. the patients presented the typical meningitic symptoms (fever, headache, stiffness of the neck). in all cases the disease ran a benign course. - epidemiologically, it was possible to trace 32/45 cases ba ...1977610256
[viral meningoencephalitis: late development].two years ago, we performed a precocious evolutive eeg study of a specimen not selected from the virus me to echo 4 burst (cepa prima) late 1972 to early 1973 (6). some time between the appearance of the first symptoms and the 8 weeks following, alterations of cerebral electrogenesis became manifest in this study. these alterations disappeared or dimished in significance in the more tardy outlines: focalization tendency, tendency to change from "suffering" to "irritative" aspect. during this yea ...1977616553
aseptic meningitis and orchitis associated with echovirus 6 infection. 1978621607
cerebrospinal fluid lysozyme in bacterial and viral meningitis.the concentration of lysozyme (lzm) in cerebrospinal fluid was determined in 25 patients with bacterial meningitis, in 18 patients with viral meningitis and in 25 control patients who had other fibrile illnesses. the concentration of lzm was less than 1.5 microgram/ml in all control patients, and slightly to markedly raised in 10 patients with viral meningitis and in 11 out of 13 patients with untreated bacterial meningitis. the concentration of lzm was significantly different in the viral and b ...1978626116
echovirus encephalitis and myositis in primary immunoglobulin deficiency.two children are described with primary hypogammaglobulinaemia and encephalitis associated with echovirus infection. one also developed a condition resembling dermatomyositis which improved after he was given infusions of plasma containing antibody to the echovirus. although both died of their encephalitis, the course of the brain disease in one of them may have been prolonged by treatment with specific antibody. these cases, together with another briefly mentioned case in an adult with congenit ...1978626516
[aseptic meningitis cause by type 6 echovirus (author's transl)]. 1978657210
optimal conditions for plaque assay of echoviruses in human embryonic lung fibroblast cells.the present paper gives optimal conditions for plaque assays tn human embryonic lung fibroblast cells with 45 echoviruses including 11 fresh isolates, covering 31 serotypes. all the viruses tested except echovirus type 23 produced plaques at a high titer in the same cells by the methods described in this communication. plaque formations by a number of strains were markedly enhanced in size or number or both by the addition of polycation.1978661010
characterization of a regulator of host cell permissiveness to a specific enterovirus. 1978664223
[production of interferon and virus-neutralizing antibodies in adult mice infected with enteroviruses during the neonatal period].newborn albino mice were inoculated with enteroviruses and in 6 weeks reinfected with homologous or heterologous strains. strains moderately pathogenic for newborn mice led to formation of specific immunologic memory. mice infected after birth with highly pathogenic strains produced specific antibodies for a long time and lacked secondary response. production of interferon was not associated either with the strain pathogenicity for newborn mice or with the presence of antibodies.1978667327
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