intravitreal antimycotic therapy and the cure of mycotic endophthalmitis caused by a paecilomyces lilacinus contaminated pseudophakos.a salvaged eye in a case of mycotic endophthalmitis is reported. the case was one of eleven in the united states resulting from luminex lens implants contaminated with amphotericin b resistant paecilomyces lilacinus, and one of two eyes salvaged in this series of cases. the fungus, recognized 28 days after the lens was inserted, was in the anterior chamber, on the psuedophakos, and in the vitreous. the therapeutic procedures included removal of the pseudophakos, radical vitrectomy and iridectomy ...1978311456
cutaneous mycosis caused by paecilomyces lilacinus.a 20-year-old woman had erythematous scaly plaques persistent for 15 years on the left cheek. cultures from scales and biopsy specimens on sabouraud's glucose agar repeatedly yielded floccose lilac colonies, and those on a czapek's solution agar plate developed deep purplish red pigment, which is characteristic of paecilomyces lilacinus. the pas stain of the tissue section showed ovoid, divergent, or club-shaped fungal elements among the inflammatory cells or in giant cells. two months after the ...1977563706
orbital paecilomycosis due to paecilomyces lilacinus (thom) samson.the first case of orbital paecilomycosis is described. fungal hyphae were found in a koh preparation of the granulomatous tissue, removed from the orbit, and also in histological sections. culture of the tissue was positive for fungus which was resistant to cycloheximide (0.5 g/l). it was identified as paecilomyces lilacinus (thom) samson (imi 213487) and shown to be pathogenic for the rabbit cornea.1979575678
enhanced production of antibiotics by pecilomyces lilacinus under alkaline conditions associated with morphological change.the production of the group of peptide antibiotics called no. 1907 by paecilomyces lilacinus was stabilized and enhanced by mono-spore isolation followed by strain improvement, and the production seemed to be related to a morphological change of the strain. unstable and a low productivity (below 10 micrograms/ml) of the antibiotics no. 1907 by p. lilacinus was greatly improved up to 140 micrograms/ml by successive mono-spore isolation along with mutagenization. alkaline conditions caused by addi ...19911368699
paecilomyces lilacinus catheter-related fungemia in an immunocompromised pediatric patient.paecilomyces lilacinus catheter-related fungemia in an immunocompromised child is reported. the presence of a central venous catheter and the patient's immunocompromised status were felt to be predisposing factors for this unusual infection. to our knowledge, this is the first description of p. lilacinus catheter-related fungemia, and our patient may be the youngest reported patient with this mycosis who was cured.19921401021
fungi of virgin and cultivated soil of salhiah desert, egypt.27 species and 13 genera of fungi were identified from virgin and cultivated soil of salhiah. the most abundant species of phosphate solubilizing fungi were aspergillus nidulans, a. niger, a flavus, penicillium lilacinum, p. frequentans and fusarium moniliforme. on cellulose agar the most prevalent species were chaetomium bostrychodes, c. olivaceum, humicola fuscoatra, aspergillus flavus, a. nidulans, a. niger, a. ochraceus, fusarium solani and f. oxysporum. on xylan agar aspergillus fumigatus, ...19902077791
hyalohyphomycosis by paecilomyces lilacinus in a renal transplant patient and a review of human paecilomyces species infections.a case of hyalohyphomycosis caused by paecilomyces lilacinus is described in a renal transplant patient. infection was localized on the left forearm. two separate cultures of the lesions yielded the same organism. histological sections disclosed hyaline elements in the tissue. the infection responded well to therapy with oral griseofulvin (500 mg daily) and the patient was cured within 45 days. forty-six cases of human infection due to paecilomyces species have been reported previously in the li ...19902194015
paecilotoxin production in clinical or terrestrial isolates of paecilomyces lilacinus strains.the production of paecilotoxin from various isolates of paecilomyces lilacinus was studied using three different media and high performance liquid chromatography (hplc). alkaline medium was found to be suitable for the production of the toxins. among 20 strains tested, 19 including four clinical isolates were found to produce the toxins. production patterns of paecilotoxins were very similar in each strain and the main toxins were a and b.19892615806
keratinophilic fungi on sheep hairs from the west bank of jordan.the mycoflora of the hair in 285 sheep from the west bank of jordan was analysed and the frequency of occurrence and the relative importance value for different fungal species found were calculated. ninety six species which belong to 36 genera were isolated. forty one of these species were either well-known agents of animal and human mycoses (trichophyton verrucosum, t. mentagrophytes, microsporum nanum, m. canis, and others), or have been isolated from human and animal lesions (arthroderma cuni ...19892797114
paecilomyces lilacinus keratitis: two case reports in extended wear contact lens wearers. 19873329072
hyalohyphomycosis caused by paecilomyces lilacinus in an aldabra tortoise. 19863505955
paecilomyces lilacinus cellulitis in an immunocompromised patient.paecilomyces lilacinus, a saprophytic soil fungus, is an uncommon human pathogen. an immunocompromised patient developed a deep cellulitis due to p lilacinus. the infection responded poorly to intravenous amphotericin b but eventually resolved after combination therapy with amphotericin b and flucytosine (5-fluorocytosine). previous in vitro studies have suggested that miconazole is the most active antifungal agent against p lilacinus.19863767401
corneal transplant infection by paecilomyces lilacinus.paecilomyces lilacinus was cultured from an ulcerated corneal transplant, sections of which, following surgical removal, revealed dense mycelial growth throughout the corneal remnant and penetrating descemet's membrane. pas-stained sections showed, in addition to the hyphae, numerous small, ovoid elements consistent with conidia of p. lilacinus. infection apparently had spread to the transplant from the recipient's cornea. the fungal isolate proved resistant, in vitro, to amphotericin b, 5-fluor ...19853901331
[isolation and study of certain properties of the proteolytic enzymes formed by penicillium lilacinum thom]. 19724272101
transformation of steroids by cell-free preparations of penicillium lilacinum nrrl 895. v. properties of 20-oxopregnane side chain cleavage and 20(alpha+beta)-oxidoreductase activities. 19744440355
monitored environment system to control cell growth, morphology, and metabolic rate in fungi by oxidation-reduction potentials.a device for the adjustment, maintenance, and monitoring of a desired oxidation-reduction potential in a liquid environment is described. the filamentous species, penicillium lilacinum and trichophyton schoenleinii, and the dimorphic species, histoplasma capsulatum, developed budding yeastlike cells when grown in a liquid medium with a low oxidation-reduction potential. when the organisms were inoculated into fresh medium, they returned to the filamentous condition as the oxidation-reduction pot ...19685636453
comparative effect of amphotericin b on rhizoctonia sp., paecilomyces lilacinus & fusarium solani in vitro & in experimental keratitis. 19816268532
paecilomyces lilacinus (thom) samson, from systemic infection in an armadillo (dasypus novemcinctus).paecilomyces lilacinus was recovered in culture from pulmonary lesions and other internal organs of a captive armadillo. impression films and smears of the lung tissue revealed numerous budding yeast-like cells, many of them appearing encapsulated and resembling intracellular forms of histoplasma capsulatum. yeast-like forms developed in culture on appropriate media at 35 degrees c. the armadillo isolate was compared in culture at both 27 degrees c and 35 degrees c with bamboo rat and human isol ...19846539506
relative efficacy of miconazole against rhizoctonia sp., paecilomyces lilacinus and fusarium solani. 19836618536
fungal endophthalmitis following intraocular lens implantation. a surgical epidemic.thirteen cases of fungal endophthalmitis were caused by paecilomyces lilacinus. in all cases an intraocular lens was inserted that had been sterilized in sodium hydroxide and neutralized in sodium bicarbonate. in 12 of the 13 cases, it was absolutely determined that a manufacturer's lot 128 was the neutralizing solution used. the same fungus that caused the endophthalmitis was cultured from several of the neutralizing solutions from lot 128. eight of the 13 eyes eventually required enucleation. ...19807190003
isolation of leucinostatin a and one of its constituents, the new amino acid, 4-methyl-6-(2-oxobutyl)-2-piperidinecarboxylic acid, from paecilomyces lilacinus a-267. 19827201464
paecilomyces lilacinus as the cause of chronic maxillary sinusitis.paecilomyces lilacinus was isolated on two separate occasions from the left antrum of a patient with chronic maxillary sinusitis. the clinical presentation and characteristics of the fungus and the sinus debris histopathology are discussed.19807430339
[severe keratomycosis. diagnosis and treatment].we reported three consecutive cases of severe fungal keratitis initially undiagnosed by corneal scrapping. corneal biopsy showed fungal elements of paecilomyces lilacinus, fusarium solani, scedosporium apiospermum. most cases of fungal keratitis could be treated successfully if adequate antifungal therapy were started early. early and accurate diagnosis is of major importance. the results of our cases confirm the superiority of corneal biopsy over corneal scrapping. corneal biopsy is a procedure ...19947822693
complicated soft tissue infection with prepatellar bursitis caused by paecilomyces lilacinus in an immunocompetent host: case report and review.documented paecilomyces lilacinus infections are quite rare. most reports involve immunocompromised patients or implanted objects. we report the first case of complicated soft tissue infection caused by p. lilacinus in an immunocompetent host. the spectrum of infections involving this fungus is reviewed.19968735119
paecilomyces sinusitis in an immunocompromised adult patient: case report and review.a case of fungal sinusitis caused by paecilomyces lilacinus that was unresponsive to amphotericin b and involved a patient with acute myeloid leukemia is described. histologic examination of sinus tissue and periorbital bone demonstrated invasion by a fungus with septate hyphae, which was identified in culture as p. lilacinus. the isolate was resistant to amphotericin b but susceptible to itraconazole. the patient responded clinically when itraconazole was added to the treatment regimen. invasiv ...19968842281
cutaneous hyalohyphomycosis caused by paecilomyces lilacinus in a patient with lymphoma. 19968912580
outbreak of invasive mycoses caused by paecilomyces lilacinus from a contaminated skin lotion.invasive mycoses are an important cause of illness and death in immunocompromised patients. infections with molds other than aspergilli have been increasingly seen in patients with hematologic cancers, but epidemics of these infections have not yet been reported.19968928986
purification and properties of poly(3-hydroxybutyrate) depolymerase from the fungus paecilomyces lilacinus d218.poly(3-hydroxybutyrate) depolymerase was purified to homogeneity from the culture filtrate of paecilomyces lilacinus d218 by column chromatography on cm-toyopearl 650m and hydroxylapatite. the molecular weight of the enzyme was estimated to be 48,000 by sds-page. maximal activity was observed near ph 7.0 and 45 degrees c. the km and vmax values for phb were 0.13(mg/ml) and 3750 (u/mg protein), respectively. the enzyme hydrolyzed phb and p-nitrophenyl fatty acids but not polycaprolactone and trig ...19979058543
in vitro antifungal activity of pneumocandin l-743,872 against a variety of clinically important molds.the in vitro activity of the new antifungal drug pneumocandin l-743,872 against 55 isolates of clinically important molds was examined by an adapted macrobroth dilution method for yeasts. pneumocandin l-743,872 exhibited in vitro antifungal activity against alternaria sp., aspergillus flavus, aspergillus fumigatus, curvularia lunata, exophiala jeanselmei, fonsecaea pedrosoi, paecilomyces variotii, and scedosporium apiospermum. the drug appeared to lack significant in vitro inhibitory activity ag ...19979257774
cutaneous paecilomyces lilacinus infection: report of two novel cases. 19979270518
immunohistologic identification of aspergillus spp. and other hyaline fungi by using polyclonal fluorescent antibodies.isolation and identification of pathogenic aspergillus and fusarium spp. from clinical materials provide the most accurate means for establishing a diagnosis of infections by these molds. such efforts, however, are not always successful. histologic diagnosis also has its limitations. in vivo the hyphae of aspergillus and fusarium spp. are very similar and their in situ manifestations are not pathognomonic. to improve the histologic diagnosis of infections by aspergillus and fusarium species, we ...19979276388
paecilomyces lilacinus endophthalmitis with secondary keratitis: a case report and literature review.a case of endogenous fungous endophthalmitis with secondary pupillary block glaucoma and corneal invasion requiring penetrating keratoplasty is reported. initially paecilomyces lilacinus was isolated from a vitreous and a lens aspirate, but a second vitreous tap revealed aspergillus fumigatus and p lilacinus. this case highlights the difficulty of diagnosing endogenous fungous endophthalmitis presenting without risk factors and the difficulties of managing such cases using the antifungous agents ...19979338682
cutaneous manifestations of paecilomyces lilacinus infection induced by a contaminated skin lotion in patients who are severely opportunistic fungal infections cause significant morbidity and death in patients who are severely immunocompromised. cutaneous lesions may be the first clinical manifestation and give the clue to early diagnosis.19989738773
cutaneous paecilomyces lilacinus infection. 19989738799
onychomycosis caused by infection with paecilomyces lilacinus. 19989990402
paecilomyces lilacinus fungemia in an adult bone marrow transplant recipient.paecilomyces lilacinus is a rare fungal pathogen in humans. we report a case of fungemia caused by p. lilacinus in a non-neutropenic adult, 120 days after bone marrow transplant. the patient's primary risk factor was the presence of an indwelling vascular catheter. her initial clinical course was characterized by fever, chills, and rigors. blood cultures from the central line and peripheral veins were positive, as was a peripheral specimen drawn after removal of the catheter. two initial periphe ...199910200935
paecilomyces lilacinus infection in a heart transplant recipient and successful treatment with terbinafine. 199910452660
use of mycelial suspension and metabolites of paecilomyces lilacinus (fungi: hyphomycetes) in control of aedes aegypti larvae.mycelial suspension of possible was assessed to examine its paecilomyces lilanicus, a fungus, detrimental effects on fourth instar larvae of aedes aegypti. the immature stages suffered 64-68% mortality with 0.5-1% mycelial suspension. there was 12-16% adult emergence which was statistically significant (p < 001). czapeckdox and pyg media metabolites were used against the third instar larvae in various concentrations. the effects were evaluated on several parameters like mortality, mean survival ...199910916617
phenotypic and genetic characterization of paecilomyces lilacinus strains with biocontrol activity against root-knot nematodes.efficient selection of fungi for biological control of nematodes requires a series of screening assays. assessment of genetic diversity in the candidate species maximizes the variety of the isolates tested and permits the assignment of a particular genotype with high nematophagous potential using a rapid novel assay. molecular analyses also facilitate separation between isolates, allowing the identification of proprietary strains and trace biocontrol strains in the environment. the resistance of ...200011006837
biological activity of paecilomyces genus against toxocara canis eggs.saprophytic soil fungi can exert ovicidal and ovistatic effects on helminths with differing degrees of efficiency. the representatives of such fungi from temperate regions, paecilomyces lilacinus (thom) samson and p. marquandii (masse) hughes, exhibit recognized ovicidal activity on some nematodes. we evaluated the action in vitro of p. lilacinus and p. marquandii on the zoonotic canine roundworm eggs of toxocara canis. eggs exposed and unexposed to fungal samples were observed by both light and ...200011068820
successful treatment of paecilomyces lilacinus endophthalmitis after foreign body trauma to the report the successful treatment of a patient with paecilomyces lilacinus endophthalmitis infection after foreign body (fb) trauma to the cornea.200111188992
in vitro fungicidal activities of voriconazole, itraconazole, and amphotericin b against opportunistic moniliaceous and dematiaceous fungi.the nccls proposed standard m38-p describes standard parameters for testing the fungistatic antifungal activities (mics) of established agents against filamentous fungi (molds); however, standard conditions are not available for testing their fungicidal activities (minimum fungicidal or lethal concentrations [mfcs]). this study evaluated the in vitro fungistatic and fungicidal activities of voriconazole, itraconazole, and amphotericin b against 260 common and emerging molds (174 aspergillus sp. ...200111230410
biotransformation of biphenyl by paecilomyces lilacinus and characterization of ring cleavage products.we examined the pathway by which the fungicide biphenyl is metabolized in the imperfect fungus paecilomyces lilacinus. the initial oxidation yielded the three monohydroxylated biphenyls. further hydroxylation occurred on the first and the second aromatic ring systems, resulting in the formation of five di- and trihydroxylated metabolites. the fungus could cleave the aromatic structures, resulting in the transformation of biphenyl via ortho-substituted dihydroxybiphenyl to six-ring fission produc ...200111282604
comparison of the e-test with the nccls m38-p method for antifungal susceptibility testing of common and emerging pathogenic filamentous fungi.the national committee for clinical laboratory standards (nccls) m38-p method describes standard parameters for testing the fungistatic antifungal activities (mics) of established agents against filamentous fungi (molds). the present study evaluated the in vitro fungistatic activities of itraconazole and amphotericin b by the e-test and the nccls m38-p microdilution method against 186 common and emerging pathogenic molds (123 isolates of aspergillus spp. [five species], 16 isolates of fusarium s ...200111283057
exogenous endophthalmitis caused by amphotericin b-resistant paecilomyces lilacinus: treatment options and visual outcomes. 200111405851
in vitro antifungal activities of the new triazole ur-9825 against clinically important filamentous fungi.we used a modified reference microdilution method (the m-38p method) to evaluate the in vitro activities of the new triazole ur-9825 in comparison with those of amphotericin b against 77 strains of opportunistic filamentous fungi. ur-9825 was clearly more active than amphotericin b against all fungi except fusarium solani and scytalidium spp. notably, ur-9825 had low mics for aspergillus fumigatus and paecilomyces lilacinus (mics at which 90% of isolates are inhibited, 0.125 microg/ml for both s ...200111502542
microbiological quality of topical drug formulations: efficacy of antimicrobial preservation against paecilomyces lilacinus.microbiological quality of topical products comprises both, the microbiological purity of the unopened product and the efficacy of the antimicrobial preservation system.200111701981
microbial, chemical and physical aspects of citrus waste composting.citrus waste supplemented with calcium hydroxide and with a c/n ratio of 24:1, ph of 6.3 and moisture content of 60% was composted by piling under shelter. with regular turning over of the pile and replenishment of moisture, the thermic phase lasted for 65-70 days and composting was completed after 3 months. compost thus prepared had an air-filled porosity of 14%, water-holding capacity of 590 ml l(-1), bulk density of 1.05 g cm(-3) and conductivity of 480 ms m(-1). phosphorus content (in mg l(- ...200211708757
[endophthalmitis due to paecilomyces lilacinus after non-surgical penetrating trauma]. 200111747798
case report. successful treatment of cutaneous paecilomyces lilacinus infection with oral itraconazole in an immune competent host.a 59-year-old woman presented to us with an eight-month history of paecilomyces lilacinus soft tissue infection. she was treated with a six-month course of oral itraconazole. the lesion resolved fully without the need for adjunctive surgery. susceptibility testing confirmed susceptibility to itraconazole. this is the second case of confirmed p. lilacinus soft tissue infection in an immunocompetent host treated with oral itraconazole alone.200111820267
progressive cutaneous hyalohyphomycosis due to paecilomyces lilacinus: rapid response to treatment with caspofungin and itraconazole.a case of rapidly progressive cutaneous infection due to paecilomyces lilacinus developed in a woman with advanced pancreatic cancer who did not have granulocytopenia. the infection responded favorably to caspofungin and itraconazole combination therapy.200211981740
diversity in soil fungi from undisturbed and disturbed celtis tala and scutia buxifolia forests in the eastern buenos aires province (argentina).the rhizospheric soil microfungi from a native forest (undisturbed and disturbed) were studied using soil dilution plate and soil washing methods. fungi were isolated using slightly acid and alkaline culture media. 54 taxa were isolated: 49 from undisturbed forest soil and 37 from disturbed forest soil. acremonium sp., aspergillus ustus, coemansia pectinata, doratomyces stemonitis, fusarium solani, f. oxysporum, gliocladium roseum, humicola fusco-atra, mortierella sp., penicillium lilacinum, tri ...200212002400
disseminated paecilomyces lilacinus infection in a patient with aids.we describe a case of disseminated paecilomyces lilacinus infection occurring in a patient with advanced hiv infection. p lilacinus is a ubiquitous environmental fungus that has been associated with infection in various immunocompromised hosts, in patients with invasive medical devices, and in contact-lens wearers. the clinical features, morphologic characteristics, and response to antifungal therapy in our patient are similar to findings reported in disseminated infection due to penicillium mar ...200212056115
voriconazole treatment of disseminated paecilomyces infection in a patient with acquired immunodeficiency syndrome.we describe a patient with poorly controlled, multidrug-resistant human immunodeficiency virus disease who developed >20 skin lesions caused by paecilomyces lilacinus. the lesions failed to improve during treatment with oral itraconazole, amphotericin b, and amphotericin b lipid complex but improved during treatment with voriconazole.200212228840
optimal testing conditions for determining mics and minimum fungicidal concentrations of new and established antifungal agents for uncommon molds: nccls collaborative study.this collaborative three-center study evaluated nccls m38-a document testing conditions and other testing conditions for the antifungal susceptibility testing of 35 isolates of aspergillus nidulans, a. terreus, bipolaris hawaiiensis, b. spicifera, cladophialophora bantiana, dactylaria constricta, fusarium solani, paecilomyces lilacinus, scedosporium prolificans, trichoderma longibrachiatum, and wangiella dermatitidis for itraconazole, three new triazoles (voriconazole, posaconazole, and ravucona ...200212354880
phylogeny of mitosporic entomopathogenic fungi: is the genus paecilomyces polyphyletic?we analyzed sequences of the divergent domain at the 5' end of the large subunit rrna gene from the mitosporic entomopathogenic fungi paecilomyces sp., paecilomyces fumosoroseus, paecilomyces farinosus, paecilomyces lilacinus, verticillium lecanii, verticillium psalliotae, beauveria bassiana, aschersonia sp., aschersonia placenta, ascomycetous cordyceps sp., and cordyceps militaris. phylogenetic analysis showed p. fumosorseus as the best characterized out of the analyzed species with the b. bass ...200111683463
ultrastructure and properties of paecilomyces lilacinus spores.strains of the filamentous soil fungus paecilomyces lilacinus are currently being developed for use as biological control agents against root-knot, cyst, and other plant-parasitic nematodes. the inoculum applied in the field consists mainly of spores. this study was undertaken to examine the size, ultrastructure, and rodlet layers of p. lilacinus spores and the effect of the culture method on structural and functional spore properties. a rodlet layer was identified on aerial spores only. other d ...200212489777
purification and characterization of a new type of alpha-glucosidase from paecilomyces lilacinus that has transglucosylation activity to produce alpha-1,3- and alpha-1,2-linked oligosaccharides.a fungus producing an alpha-glucosidase that synthesizes alpha-1,3- and alpha-1,2-linked glucooligosaccharides by transglucosylation was isolated and identified as paecilomyces lilacinus. the cell-bound enzyme responsible for the synthesis was extracted by suspension of mycelia with 0.1 m phosphate buffer (ph 8.0), and the extract was purified. the molecular weight and the isoelectric point were estimated to be 54,000 and 9.1, respectively. the enzyme was most active at ph 5.0 and 65 degres c. t ...200312619670
[paecilomyces lilacinus systemic infection in an immunocompromised child].the incidence of systemic fungal infections increased during the last two decades. rare fungi, such as mucor, fusarium and paecilomyces, are emerging as causes of systemic fungal infections in immunocompromised hosts. there are reports of cutaneous infections, endophthalmitis, keratitis, sinusitis, neuropathy and fungemia in immunocompromised and immunocompetent adult patients. we report a 5 years old neutropenic patient with acute myeloid leukemia treated with multiple courses of chemotherapy, ...200312643223
cutaneous hyalohyphomycosis caused by paecilomyces lilacinus in a renal transplant patient.we describe a renal transplant recipient with cutaneous hyalohyphomycosis due to paecilomyces lilacinus and highlight the increasing importance of such opportunistic fungal infections in immunosuppressed patients.200011069476
cutaneous infection caused by paecilomyces lilacinus in a renal transplant patient: treatment with voriconazole.moulds belonging to the genus paecilomyces are rare opportunistic pathogens. about 100 cases have been reported in immunocompromised hosts or in relation to surgical procedures. we describe here a cutaneous infection due to p. lilacinus in a renal transplant patient, which responded to voriconazole treatment.200010879613
fungal egg-parasites of plant-parasitic nematodes from spanish soils.we have investigated the presence of fungal egg-parasites in spanish soils with plant endoparasitic nematodes. nine out of 68 samples (13%) yielded fungal parasites. the most common (seven strains) was pochonia chlamydosporia var. chlamydosporia (= verticillium chlamydosporium var. chlamydosporium), but lecanicillium lecanii (= verticillium lecanii) and paecilomyces lilacinus were also found. most strains were from cyst nematodes (heterodera avenae or heterodera schachtii). biological factors re ...200212828513
combined surgical and antifungal treatment of a subcutaneous infection due to paecilomyces lilacinus.paecilomyces lilacinus was the causal agent of a case of subcutaneous infection in a patient with liver cirrhosis. surgical treatment in combination with systemic amphotericin b therapy led to complete recovery. retrospectively performed microdilution testing revealed dose dependent in vitro susceptibility of the isolate to voriconazole (mic = 2 g/ml) and terbinafine (mic = 1 microg/ml).200312964718
paecilomyces lilacinus vaginitis in an immuno-competent patient.paecilomyces lilacinus, an environmental mold found in soil and vegetation, rarely causes human infection. we report the first case of p. lilacinus isolated from a vaginal culture in a patient with vaginitis.200314519255
testing the nematophagous biological control strain paecilomyces lilacinus 251 for paecilotoxin production.paecilomyces lilacinus is a nematophagous fungus currently developed as a biological control agent. in order to evaluate potential toxin production, culture extract and concentrated culture supernatant of p. lilacinus strain 251 were tested against gram-negative and gram-positive bacteria. high-performance liquid chromatography analysis was carried out to compare the chromatograms of p. lilacinus strain 251 with the chromatogram of known paecilotoxin. it was found that the 251 strain of p. lilac ...200314568155
liposome-based formulations for the antibiotic nonapeptide leucinostatin a: fourier transform infrared spectroscopy characterization and in vivo toxicologic study.leucinostatin-a is a nonapeptide isolated from paecilomyces marquandii, paecilomyces lilacinus a257, and acremonium sp., exerting remarkable phytotoxic, antibacterial (especially against gram-positive) and antimycotic activities. with the aim to find alternative formulation for in vivo administration, a number of leucinostatin-a-loaded liposomal formulations have been prepared and characterized. both large unilamellar vesicles and multilamellar vesicles consisting of synthetic and natural lipids ...200014727851
cutaneous paecilomycosis in a cat.a cat was presented for a 2-year history of a recurrent, soft-tissue swelling of the left metacarpal region. the mass was excised and submitted for aerobic and anaerobic bacterial culture, fungal culture, and histopathological examination. cultures revealed the organism paecilomyces lilacinus, and histopathological examination showed a nodular mycotic granuloma. itraconazole (10 mg/kg body weight, per os [po], q 24 hours) was administered and continued for a total of 60 days, with a swelling of ...200314736719
purification and characterization of a serine protease and chitinases from paecilomyces lilacinus and detection of chitinase activity on 2d gels.the filamentous fungus paecilomyces lilacinus is currently developed as a biocontrol agent against plant parasitic nematodes. nematode eggs and cuticles are the infection sites for biocontrol agents that penetrate by the production of lytic enzymes. p. lilacinus was cultured in liquid media and proteases and chitinases were induced by the introduction of egg yolk and chitin, respectively. a serine protease was purified from a culture medium using sepharose-bacitracin affinity column. the proteas ...200314965766
molecular characterization of a rhodotorula-lytic enzyme from paecilomyces lilacinus having beta-1,3-mannanase activity.we cloned the gene and corresponding cdna for an extracellular rhodotorula-lytic enzyme which has beta-1,3-mannase activity, tentatively named man5c, from paecilomyces lilacinus. man5c showed a high homology score with the members of glycoside hydrolase family 5 in a domain search with the pfam database, indicating that man5c is a novel and unique member of glycoside hydrolase family 5.200415056915
cutaneous hyalohyphomycosis caused by paecilomyces lilacinus in an immunocompetent host successfully treated with itraconazole: case report and review.paecilomyces lilacinus is an emerging fungal pathogen that is highly resistant to many antifungal drugs. skin and subcutaneous soft tissue infections caused by this organism are very unusual. most cases occur in patients with impaired host defenses or following surgical procedures. there has been only one previous report of a histologically confirmed cutaneous infection due to paecilomyces lilacinus in a patient without predisposing factors. described here is the second histopathologically prove ...199910614958
ecology of cycloheximide-resistant fungi in field soils receiving raw city wastewater or normal irrigation water.the effect of raw city wastewater irrigation on biodiversity and population densities of a cycloheximide-resistant (ch) fungal community was studied in 13 field soils receiving either raw city wastewater or normal irrigation, and in raw city wastewater in the nablus area, using the hair baiting technique (hbt) and a surface soil dilution plating (ssdp) technique. three of these fields [one had been receiving raw city wastewater for more than ten years and was designated a heavily polluted field, ...199810422272
production of leucinostatins and nematicidal activity of australian isolates of paecilomyces lilacinus (thom) evaluate the relationship between leucinostatin production by paecilomyces lilacinus isolates and their biological activities.200415214724
lung abscess caused by paecilomyces lilacinus.we report the case of a 57-year-old man who was referred to our department for further investigation of an abnormal chest shadow. radiography on admission demonstrated a coin lesion in the right hilum. to make a final diagnosis, right middle lobectomy was performed and the mass was revealed to be a fungal abscess. further examination confirmed that the fungus was paecilomyces lilacinus. this is the first reported case of lung abscess caused by p. lilacinus in an otherwise healthy person.19999973699
infection due to paecilomyces lilacinus: a challenging clinical identification.we describe a case of noninvasive sinusitis caused by paecilomyces lilacinus in a patient with diabetes mellitus. cure was achieved by endoscopic drainage and aspiration of the fungal mass. we discuss the difficulty in and clinical importance of distinguishing paecilomyces from aspergillus.19979431388
morphologic criteria for the preliminary identification of fusarium, paecilomyces, and acremonium species by histopathology.nontraditional human pathogenic fungi, including fusarium, paecilomyces, and acremonium species, have been increasingly documented as agents of infection in immunocompromised patients and, occasionally, in normal hosts. although definitive identification of these fungi requires culture, they often can be identified provisionally in tissue sections by a combination of histologic features, including hyaline septate hyphae and characteristic reproductive structures known as phialides and phialoconi ...19989426517
development of a bionematicide with paecilomyces lilacinus to control meloidogyne incognita.root-knot disease caused by meloidogyne incognita is a matter of grave concern because it affects several economically important crop plants. the use of solid-state fermentation (ssf) may help to elaborate efficient formulations with fungi to be employed in the biologic control of nematodes. attempts were made to select low-cost substrates for spore production of a strain of paecilomyces lilacinus with known nematicide capacity. coffee husks, cassava bagasse, and defatted soybean cake were utili ...200415304741
cutaneous hyalohyphomycosis caused by paecilomyces lilacinus: report of three cases and review of the literature.cutaneous infection with paecilomyces lilacinus is encountered worldwide, with most infections occurring either iatrogenically or in immunocompromised hosts. we report three cases of cutaneous hyalohyphomycosis caused by p. lilacinus, one of which occurred in an immunocompetent individual. in addition, we review the 17 cases previously reported in the literature. although this infection can be difficult to treat, most cases are not fatal. most cases responded well to systemic azole antifungal ag ...200415357743
an outbreak of phialemonium infective endocarditis linked to intracavernous penile injections for the treatment of march 2002, a patient in tel aviv, israel, died of endocarditis caused by phialemonium curvatum. as part of his therapy for erectile dysfunction, the patient had been trained to self-inject a compound of vasoactive drugs provided by an impotence clinic into his penile corpus cavernosous.200515736008
the new fungal opportunists are coming.frequent and prolonged exposure of immunocompromised patients to a variety of environmental conditions has resulted in the recognition of infections with new fungal opportunists. infections with fungi such as fusarium species, paecilomyces lilacinus, acremonium species, trichosporon beigelii, blastoschizomyces capitatus, malassezia furfur, penicillium marneffei, scedosporium prolificans, and other dematiaceous species have become significant problems in the treatment of immunocompromised hosts. ...19968722837
[endophthalmitis caused by paecilomyces lilacinus after cataract surgery: a case report].a case of fungal endophthalmitis caused by paecilomyces lilacinus after cataract surgery is reported. an 84-year-old woman had been suffering from diabetes mellitus and hypertension. she underwent an uncomplicated extracapsular cataract extraction with implantation of a posterior chamber intraocular lens in the right eye. approximately one month after the surgery iritis was noted, and treated systemically and topically with corticosteroids and antibiotics. the inflammation was improved by these ...19948109439
dna markers for differentiating isolates of paecilomyces lilacinus.paecilomyces lilacinus is an agent for the potential biological control of soil nematodes. arbitrarily primed pcr was used to fingerprint the genomes of 28 isolates of this fungus. most (72%) of the isolates originated from soil of different regions of brazil. fourteen 10-mer oligonucleotide primers of arbitrary sequence revealed 293 scorable binary characters. distinct genotypes were obtained for each isolate. cluster analysis showed a high level of variability among these genotypes. the simila ...19957894717
effect of paecilomyces lilacinus on the viability of oncospheres of taenia hydatigena.paecilomyces lilacinus (thom) samson is a saprophytic hyphomycete from the soil with biological activity on helminth eggs. we evaluated the influence in vitro of p. lilacinus on the viability of the oncospheres from taenia hydatigena, a parasite cestode of dogs and sheep. the eggs were exposed to the fungus strain in sterile distilled water and observed by light microscopy at days 4, 7 and 14 post-inoculation, and the viability was evaluated. the viability found in the exposed p. lilacinus oncos ...200515950384
a basic serine protease from paecilomyces lilacinus with biological activity against meloidogyne hapla eggs.scanning electron micrographs of the nematode-egg-parasitic fungus paecilomyces lilacinus infecting eggs of the root-knot nematode meloidogyne spp. suggested the involvement of lytic enzymes. when grown on a liquid mineral salts medium, supplemented with different substrates as the sole n- and c-source, the fungus produced an extracellular protease. colloidal chitin, vitellin and intact eggs of the root-knot nematode meloidogyne hapla induced proteolytic activity that was repressed by glucose. t ...19957773385
penetrating keratoplasty for exogenous paecilomyces keratitis followed by postoperative endophthalmitis.three patients developed paecilomyces lilacinus keratitis while being treated with topical corticosteroids and antibiotics. the first patient, a diabetic man, suffered superficial ocular trauma while being treated for recurrent anterior uveitis related to an iris-fixated intraocular lens. the second patient developed keratitis while being treated for anterior segment inflammation associated with herpes zoster ophthalmicus. the third patient, a woman with chronic lymphoma in remission, was receiv ...19846541878
leucinostatins, peptide mycotoxins produced by paecilomyces lilacinus and their possible roles in fungal infection.peptide mycotoxins "leucinostatins" were obtained from the culture strains of paecilomyces lilacinus, which were isolated both from soil and a case of human oculomycosis. comparative studies of the symptoms of experimental keratomycosis caused both by the inoculation of p. lilacinus and by direct administration of leucinostatins into the infection model in rabbit suggested the possible role of leucinostatins in the inflammatory response of invaded tissues. leucinostatin was formerly reported as ...19846485630
the use of real-time pcr and species-specific primers for the identification and monitoring of paecilomyces lilacinus.the paecilomyces lilacinus is the most widely tested fungus for the control of root-knot and cyst nematodes. the fungus has also been implicated in a number of human and animal infections, difficulties in diagnosis often result in misdiagnosis or delays in identification leading to a delay in treatment. here, we report the development of species-specific primers for the identification of p. lilacinus based on sequence information from the its gene, and their use in identifying p. lilacinus isola ...200516329874
successful treatment of fungal keratitis caused by paecilomyces lilacinus. 19846333822
successful treatment of paecilomyces lilacinus endophthalmitis following cataract extraction with intraocular lens implantation.we report a case of mycotic endophthalmitis caused by paecilomyces lilacinus after cataract surgery. treatment consisted of early vitrectomy, multiple intravitreal injections of amphotericin b and miconazole, intravenous miconazole and, later, oral ketoconazole. the intraocular lens, which initially appeared uninvolved, was removed six weeks after initiation of therapy and found to contain causative organisms. final visual acuity was 20/20. we recommend aggressive therapy consisting of early vit ...19873495760
oxidative ring cleavage of low chlorinated biphenyl derivatives by fungi leads to the formation of chlorinated lactone derivatives.the yeast trichosporon mucoides and the filamentous fungus paecilomyces lilacinus as biphenyl oxidizing organisms are able to oxidize chlorinated biphenyl derivatives. initial oxidation of derivatives chlorinated at c4 position started at the non-halogenated ring and went on up to ring cleavage. the products formed were mono- and dihydroxylated 4-chlorobiphenyls, muconic acid derivatives 2-hydroxy-4-(4-chlorophenyl)-muconic acid and 2-hydroxy-5-(4-chlorophenyl)-muconic acid as well as the corres ...200616352329
systemic mycotic disease of captive crocodile hatchling (crocodylus porosus) caused by paecilomyces lilacinus.the sudden death occurred of a captive estuarine crocodile hatchling (crocodylus porosus). on autopsy, granuloma-like lesions were seen in the liver, left lung and spleen, and branching, septate fungal hyphae were observed in sections of liver and spleen. the fungus isolated from the liver showed characteristics of both paecilomyces lilacinus and paecilomyces marquandii but was closer to the former species. this is apparently the first report of the isolation of this fungus from a reptile in aus ...19883216279
keratinophilic fungi from the duck nails in egypt.the mycoflora of one hundred and sixty of duck nail samples, collected from the duck farm, faculty of agriculture, assiut university, were examined. using the soil plate technique and sabouraud's dextrose agar, thirty six species appertaining to twenty genera of keratinophilic fungi were isolated. chrysosporium was the genus most frequently isolated (50% of the samples). aspergillus and penicillium occurred in low incidences (13.1 and 12.5% of total samples). trichophyton rubrum was found to col ...19892778647
comparison of preparation techniques of mixed samples (fungi-helminth eggs) for scanning electron microscopy by critical point drying.we compared three preparation techniques for critical point drying of fungus paecilomyces lilacinus (thom) samson with toxocara canis (werner) johnston and taenia hydatigena linneo eggs by scanning electron microscopy. we evaluated filtration (first), centrifugation (second), and phytoplankton network (third) in critical point drying methods. the first and third methods were advantageous for t. canis eggs because they preserved the quantity and quality of samples to obtain better images definiti ...200616607559
paecilomyces lilacinus infection in an immunocompromised patient.systemic infections caused by saprophytic fungi are being diagnosed more frequently. we describe the second reported instance of paecilomyces lilacinus causing infection in an immunocompromised host. the diagnosis and treatment of this unusual pathogen are discussed.19902277228
[paecilomyces lilacinus--sensitivity to disinfectants].in conjunction with nosocomial infection of opthalomycoses in the ophthalmological department, from the enucleated eye and from ringer solution (used during operations) a fibrous microscopic fungus paecilomyces lilacinus was isolated. during sensitivity tests of the isolated strain to locally used disinfectants and chemical sterilizing agents it was revealed that the strain was not killed even by the action of higher concentrations of disinfectant solutions, used in our health departments accord ...19902150619
paecilomyces lilacinus infection in a child with chronic granulomatous disease.chronic granulomatous disease (cgd) is a rare inherited disorder in which neutrophils do not appropriately generate cytotoxic superoxide anion, the respiratory burst, in response to invading bacteria or fungi as a part of normal host defence. we report the case of a child with cgd who had two abdominal wall abscesses caused by paecilomyces lilacinus, an organism not previously known to cause infections in patients with cgd. the abdominal wall is a location that is rarely associated with paecilom ...19921533235
post-traumatic fungal endophthalmitis--a prospective study the incidence, clinical presentation, and the response of anti-fungals in cases of fungal endophthalmitis following open globe injury.200816751752
paecilomyces lilacinus cutaneous infection associated with a dog bite. 200616843134
[conditions for dextranase formation by paecilomyces lilacinus].induced formation conditions of dextranase by paecilomyces lilacinus were investigated. effect of various carbohydrates on dextranase formation was examined, dextran was the best c-source and as an inducer. the effect of dextran with different molecular weight (from 17.2 to 1000 kd) on dextranase formation was compared, productivity of dextranase increased with increase of dextran molecular weight. when dextran of 1000 kd was used as c-source. the enzyme formation was 40% higher than that 17.2 k ...19921282760
fungal endophthalmitis caused by paecilomyces lilacinus after intraocular lens implantation. 1977299984
integrated application of some compatible biocontrol agents along with mustard oil seed cake and furadan on meloidogyne incognita infecting tomato plants.experiments were carried out to study the effect of two fungal bioagents along with mustard oil cake and furadan against root knot nematode meloidogyne incognita infecting tomato under greenhouse condition. bioagents viz., paecilomyces lilacinus and trichoderma viride alone or in combination with mustard cake and furadan promoted plant growth, reduced number of galls/plant, egg masses/root system and eggs/egg mass. the fungal bioagents along with mustard cake and nematicide showed least nematode ...200617048300
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