| a novel oncogene, v-ryk, encoding a truncated receptor tyrosine kinase is transduced into the rpl30 virus without loss of viral sequences. | the rpl viruses are acute oncogenic avian retroviruses isolated from chicken tumors. we carried out a genetic analysis of three of the viruses, rpl25, rpl28, and rpl30. while rpl25 and rpl28 were shown to contain the erbb oncogene, rpl30 appeared to contain a novel protein tyrosine kinase oncogene. this gene, v-ryk, was cloned and sequenced. the v-ryk oncogene contains a 1.39-kb nonretroviral sequence that includes a tyrosine kinase domain which was inserted into the viral envelope protein gp37- ... | 1992 | 1527848 |