| mutations in the protein kinase-binding domain of the ns5a protein in patients infected with hepatitis c virus type 1a are associated with treatment response. | an interaction of the hepatitis c virus (hcv) ns5a protein with the interferon (ifn)-alpha-inducible double-stranded rna-activated protein kinase (pkr) was demonstrated in vitro. the clinical correlation between amino acid mutations within the hcv ns5a region and response to antiviral treatment is controversial. thirty-two patients chronically infected with hcv-1a, who were treated with ifn-alpha with or without ribavirin, were studied. the carboxy-terminal half of hcv ns5a was sequenced and was ... | 2000 | 10669323 |