| cj-15,696 and its analogs, new furopyridine antibiotics from the fungus cladobotryum varium: fermentation, isolation, structural elucidation, biotransformation and antibacterial activities. | cj-15,696 and 7 novel furopyridine antibiotics were isolated from the fungus cladobotryum varium cl12284. their structures were determined by x-ray crystallography and spectral analysis. three biotransformed analogs were also prepared from cj-15,696. cj-15,696 showed moderate activity against various gram-positive bacteria including some drug resistant strains such as methicillin resistant staphylococcus aureus (mrsa). | 2002 | 11918067 |
| cladobotryal: a fungal metabolite with a novel ring system. | in screening for antifungal metabolites a novel compound, cladobotryal, was isolated from the mycoparasitic fungus cladobotryum varium. its structure was established as (+)-(2r*,3r*)-2-[(z)-2-buten-2-yl]-3, 7-dihydro-3-formyl-3-methyl-5-phenylfuro[2,3-b]pyridin-4(2h)-one on the basis of spectroscopic evidence and single crystal x-ray analysis of its methyl hemiacetal. the fused furo[2,3-b]pyridinone skeleton of cladobotryal seems unprecedented within the chemical literature. | 1998 | 9586194 |