| epitope mosaic on the surface proteins of orthopoxviruses. | epitopes on the surface components of orthopoxviruses were analyzed with monoclonal antibodies (mabs) against monkeypox and vaccinia viruses by enzyme-linked immunosorbent assay (elisa), western blotting (wb), radioimmunoprecipitation (rip), and competitive binding inhibition assay (cbia). when compared by elisa, three vaccinia virus strains exhibited a similar reactivity to 99 tested mabs despite their remote passage history. all five isolates of monkeypox virus closely resembled one another, i ... | 1988 | 2450423 |
| poxviruses as possible vectors for horizontal transfer of retroposons from reptiles to mammals. | poxviruses (poxviridae) are a family of double-stranded dna viruses with no rna stage. members of the genus orthopoxvirus (opv) are highly invasive and virulent. it was recently shown that the taterapox virus (tatv) from a west african rodent is the sister of camelpox virus and therefore belongs to the clade closest to the variola virus (varv), the etiological agent of smallpox. although these opvs are among the most dreaded pathogens on earth, our current knowledge of their genomes, their origi ... | 2007 | 17623783 |
| prediction of steps in the evolution of variola virus host range. | variola virus, the agent of smallpox, has a severely restricted host range (humans) but a devastatingly high mortality rate. although smallpox has been eradicated by a world health organization vaccination program, knowledge of the evolutionary processes by which human super-pathogens such as variola virus arise is important. by analyzing the evolution of variola and other closely related poxviruses at the level of single nucleotide polymorphisms we detected a hotspot of genome variation within ... | 2014 | 24626337 |
| genome-wide comparison of cowpox viruses reveals a new clade related to variola virus. | zoonotic infections caused by several orthopoxviruses (opv) like monkeypox virus or vaccinia virus have a significant impact on human health. in europe, the number of diagnosed infections with cowpox viruses (cpxv) is increasing in animals as well as in humans. cpxv used to be enzootic in cattle; however, such infections were not being diagnosed over the last decades. instead, individual cases of cowpox are being found in cats or exotic zoo animals that transmit the infection to humans. both ani ... | 2013 | 24312452 |
| evaluation of taterapox virus in small animals. | taterapox virus (tatv), which was isolated from an african gerbil (tatera kempi) in 1975, is the most closely related virus to variola; however, only the original report has examined its virology. we have evaluated the tropism of tatv in vivo in small animals. we found that tatv does not infect graphiurus kelleni, a species of african dormouse, but does induce seroconversion in the mongolian gerbil (meriones unguiculatus) and in mice; however, in wild-type mice and gerbils, the virus produces an ... | 2017 | 28763036 |