| immunization against nippostrongylus brasiliensis in the rat. a study on the use of antigen extracted from adult parasites and the parameters which influence the level of protection. | it was found that protective immunity in excess of 90% reduction in worm burden could be stimulated against nippostrongylus brasiliensis in rats by using an extract of adult nippostrongylus worms. the level of protection achieved was influenced by several factors. thus, the use of bordetella pertussis as adjuvant significantly increased the level of protection which, in addition, was shown to be influenced by the amount of worm antigen used. furthermore, antigen administered in multiple doses wa ... | 1979 | 44095 |
| ige levels in nude mice. | ige levels in nude mice were estimated by the one-step single radial radiodiffusion method antisera prepared by immunization of guinea pigs with an ige-rich fraction obtained from sera of normal mice infected with nippostrongylus brasiliensis and immunized with dnp-ovalbumin in alum gel. 3 out of 8 nude mice had ige levels significantly higher than those of normal mice. | 1979 | 108225 |
| evidence that aspergillus fumigatus growing in the airway of man can be a potent stimulus of specific and nonspecific ige formation. | serum ige levels in patients with allergic bronchopulmonary aspergillosis are elevated but the degree of elevation varies markedly. serum ige levels in patients with aspergillomas may be strikingly elevated or normal. absorption of serums with antigens of aspergillus fumigatus combined with a solid phase radioimmunoassay technic demonstrated that both immunoglobulin e (ige) and immunoglobulin g (igg) antibody activity against a. fumigatus were markedly reduced without a parallel reduction in ser ... | 1977 | 329672 |
| nippostrongylus brasiliensis: intestinal goblet-cell response in adoptively immunized rats. | | 1979 | 421768 |
| expulsion of nippostrongylus brasiliensis from mice lacking antibody production potential. | expulsion of the intestinal nematode of rodents, nippostrongylus brasiliensis, was assessed in mice experiencing the immunosuppressive effects of anti-micron antibodies. anti-micron treatment resulted in complete elimination of igm and severe reduction of igg1, igg2 and iga serum immunoglobulin levels. specific antibody responses to sheep erythrocytes were virtually eliminated in anti-micron-treated mice as determined by direct and indirect plaque-forming-cell responses, haemagglutination and ha ... | 1977 | 328383 |
| the pasteur effect in rat jejunum and the influence of nematode infections. | 1. the pasteur effect was shown after 15 min but not after 30 min incubation of jejunal rings from normal rats. 2. during 15-30 min incubation, the rate of anaerobic lactate production decreased, while aerobic lactate production remained unchanged. thus oxygen was necessary to maintain the functional integrity of the tissue during this period. 3. after infection with either nematospiroides dubius or nippostrongylus brasiliensis, the pasteur effect could not usually be shown, mainly due to a redu ... | 1978 | 318282 |
| nippostrongylus brasiliensis: mast cells and histamine levels in tissues of infected and normal rats. | | 1979 | 456459 |
| mass cells in ocular tissues of normal rats and rats infected with nippostrongylus brasiliensis. | in orbital exenteration specimens from 14 rats, 93% of the mast cells were found in the lids, the limbus, and the conjunctiva, 5% in the orbital tissues, and less than 1% in the globe. the density of mast cells was highest in lid (2843/mm3), limbus (2822/mm3), and orbit (2184/mm3) and lowest in bulbar conjunctiva (794/mm3), ciliary body (512/mm3), and sclera (176/mm3). there was no significant difference in the distribution or density of mast cells in orbital exenteration specimens from normal r ... | 1979 | 457360 |
| studies on chronic versus transient intestinal nematode infections in mice. i. a. comparison of responses to excretory/secretory (es) products of nippostrongylus brasiliensis and nematospiroides dubius worms. | | 1979 | 317840 |
| immunologically mediated intestinal mastocytosis in nippostrongylus brasiliensis-infected rats. | to investigate mechanisms of mast-cell proliferation, we have utilized infection of lewis rats with the intestinal nematode, nippostrongylus brasiliensis, which induces a pronounced intestinal mast-cell hyperplasia. adoptive transfer of 2 x 10(8) immune mesenteric lymph node cells (imln), collected 14 days post infection with 3000 third stage larvae (l3), into rats concurrently given 3000 l3 hastened the expected intestinal mastocytosis by up to 4-5 days. imln exhibited this mastopoietic activit ... | 1979 | 315919 |
| mast cells in severely t-cell depleted rats and the response to infestation with nippostrongylus brasiliensis. | the effect of severe t-cell depletion on mucosal mast cells of the small intestine and on connective tissue mast cells has been studied in adult thymectomized, irradiated, bone marrow reconstituted (b) rats. under normal conditions, intestinal mucosal mast cell numbers do not differ significantly between b rats, normal age matched rats and non-thymectomized irradiated controls. connective tissue mast cells are significantly fewer in the tongues of b rats than in normal rats, but the difference i ... | 1979 | 313898 |
| potentiation of ige response in vitro by t cells from rats infected with nippostrongylus brasiliensis. | | 1979 | 313423 |
| lymphocytes bearing fc receptors for ige. ii. induction of fcepsilon-receptor bearing rat lymphocytes by ige. | the proportion of lymphocytes bearing receptors for ige (fcepsilonr) markedly increased after infection of rats with nippostrongylus brasiliensis (nb). the fcepsilonr-bearing lymphocytes from the infected animals bound more ige-coated erythrocytes in rosette assay than fcepsilonr-bearing cells from normal rats, suggesting that the number of fcepsilonr per cell may also increase following the infection. in contrast, the number of ige-receptors on peritoneal mast cells did not change after nb infe ... | 1979 | 312882 |
| development of ige-forming cells in vitro from rat mesenteric lymph node cells. | mesenteric lymph node cells from normal rats and rats infected with nippostrongylus brasiliensis (nb) were cultured with pokeweed mitogen (pwm) or nb antigen, and the development of igm-, igg2a-, or ige-containing cells was assessed by immunofluorescence. normal lymph node cells stimulated with pwm developed into both igm- and ige-containing cells, whereas similar stimulation of cells from nb-infected rats resulted in the development of igm-, igg2a-, and ige-containing cells. the in vitro plasma ... | 1978 | 309901 |
| ige-b cell-generating factor from lymph node cells of rats infected with nippostrongylus brasiliensis. ii. effector mechanisms of ige-b cell-generating factor. | | 1978 | 307571 |
| ige-b cell-generating factor from lymph node cells of rats infected with nippostrongylus brasiliensis. i. source of ige-b cell-generating factor. | | 1978 | 307570 |
| the immunological consequences of nematode infection. | nematode infections in the gut induce a strong immune response which is rapidly detected parenterally. the response is thymus-dependent and long-lasting and involves both antibodies and cell-mediated reactions. the immunological response to unrelated antigens, tumours and other infectious organisms is altered in animals infected with nematodes. both antibodies and sensitized lymphocytes participate in the immune response which affects the nematodes themselves, and characteristically the lymphocy ... | 1977 | 305838 |
| ige formation in the rat following infection with nippostrongylus brasiliensis. iii. soluble factor for the generation of ige-bearing lymphocytes. | normal rat bone marrow cells incubated with serum or lymph from nippostrongylus brasiliensis (nb)-infected rats showed an increase in the proportion of ige-bearing cells in culture. this effect was produced in a similar fashion by cell-free supernatants (cfs) from cultures of mesenteric lymph node cells obtained from nb-infected rats. the action of cfs on bone marrow cells appeared to be specific for the generation of ige-bearing cells since the proportion of igm-bearing cells in the culture did ... | 1977 | 301898 |
| tolerizing effect of dnp-ficoll on ige antibody production. | a/j and dba/1 mice were infected with 750 third-stage larvae of nippostrongylus brasiliensis and immunized with 1 mug dinitrophenylated n. brasiliensis extract (dnp-nb) with 1 mg al(oh)3 to produce high titers of anti-hapten igg1 and ige antibody. partial tolerance to the production of anti-hapten igg1 and ige antibody could be induced by dnp-ficoll from 5 weeks before to 1 week after the dnp-nb immunization. the tolerized state persisted through the duration of the experiments. however, no tole ... | 1977 | 299759 |
| the production of ige and igga antibodies in normal rats and rats infected with nippostrongylus brasiliensis. | the time courses of production of ige and igga homocytotropic antibodies were measured in wistar rats during a primary and secondary response to egg albumin with pertussis or freund's adjuvants. an anamnestic ige antibody response occurred in animals previously sensitized to antigen with killed bordetella pertussis as adjuvant. igga antibodies were formed in the primary response with freund's complete adjuvant only, but were found during the secondary response with all adjuvants used. the time ... | 1976 | 178591 |
| phosphorylcholine antigens from nippostrongylus brasiliensis. ii.--isolation and partial characterization of phosphorylcholine antigens from adult worm. | the phosphorylcholine antigens (c substance) were specifically isolated from nippostrongglus brasiliensis adult worms. they formed a gorup of fairly closely related molecules, but it was not possible to evidence that the carrier molecule was unique. an indirect immunoenzymatic test using immobilized lectins (concanavalin a, phytohaemagglutinin els, wheat germ agglutinin, recin types i and ii, peanut agglutinin) gave some light on the carbohydrate composition of the carrier molecules, whereas the ... | 1979 | 95087 |
| development of mast cells in vitro. ii. biologic function of cultured mast cells. | mast cells were obtained by long term culture of rat thymus cells on rat embryonic fibroblast monolayers. pure mast cell preparations obtained culture were incubated with 125i-labeled rat e myeloma protein to study receptors for ige on their surface. when the cells were obtained after 35 to 45 days culture, the average number of receptors per mast cell was 100,000 to 400,000. an equilibrium constant of the binding reaction between their receptor and rat ige was in the order of 108 m-1. the hista ... | 1977 | 63515 |
| immunologic properties of mast cells from rats infected with nippostrongylus brasiliensis. | the concentration of ige in the serum of sprague-dawley rats increased after infection with nippostrongylus brasiliensis (nb). the ige concentration in normal rats was less than 1 mug/ml. after re-infection with nb, the concentration increased in 100 to 300 mug/ml. mast cells were purified from peritoneal cells of both normal and nb-infected animals. purified mast cells from the infected animals released histamine upon exposure to nb antigen. the antibody specific for ige released histamine from ... | 1975 | 51873 |
| [effect of injection of a phosphorylcholine-containing compound from nippostrongylus brasiliensis on the infestation of the rat by this parasite]. | rats were injected intradermally with the purified phosphorycholine bearing component of the nematode nippostrongylus brasiliensis. eight days later they were experimentally infected with 1 x 10(3) infective larvae of the parasite. compared to the non injected controls we showed a significant decrease in the number of adult worms able to be established in the small intestine. this protective effect seems to be due at least partly to a phenomenom being located between the skin and the lungs of th ... | 1975 | 51694 |
| effect of iron and protein deficiency on the expulsion of nippostrongylus brasiliensis from the small intestine of the rat. | the relationship between iron deficiency and protein deficiency and infestation of the rat with the nematode nippostrongylus brasiliensis was investigated. there was a significant delay in the expulsion of n. brasiliensis from the small intestine of both iron deficient and protein deficient animals and those with a combined deficiency of iron and protein. iron repletion returned the time of worm expulsion to normal and this would appear to be related to iron deficiency per se rather than to anae ... | 1977 | 558135 |
| effects of local delayed hypersensitivity on the small intestine. | there are many t and b cells in the small intestinal mucosa and local t cell immunity could have a role both in protective immunity and as a cause of disease (i.e. hypersensitivity). this latter aspect has been investigated by using several animal models to assess the effects of local delayed hypersensitivity on the structure and function of the small intestine. heterotopically transplanted grafts of fetal small intestine in mice (isografts and allografts) have been examined by conventional hist ... | 1977 | 25166 |
| nippostrongylus brasiliensis infection in the rat: effect of iron and protein deficiency on the anthelmintic efficacy of mebendazole, pyrantel, piperazine, and levamisole. | the benzimidazole anthelmintics mebendazole and fenbendazole have been shown to be much less effective against nippostrongylus brasiliensis infections in the rat on a combined iron and protein deficient diet. in the present experiments it was shown that the anthelmintic efficacy of mebendazole was significantly impaired in the rat on either an iron deficient or a protein deficient diet. furthermore, iron and protein deficiency reduced the efficacy of the anthelmintics pyrantel and piperazine but ... | 1979 | 447110 |
| adoptive transfer of the intestinal mast cell response in rats infected with nippostrongylus brasiliensis. | | 1979 | 427878 |
| the effect of iron and protein deficiency on the development of acquired resistance to reinfection with nippostrongylus brasiliensis in rats. | iron and protein deficiency delays the immunological rejection of nippostrongylus brasiliensis from the small intestine of rats undergoing a primary infection with the parasite. in the present study, iron and protein deficiency significantly reduced acquired resistance to reinfection with n. brasiliensis. repletion of deficient animals with iron and protein restored their capacity to mount an effective immune response to a secondary infection with the parasite. these results suggest that chemoth ... | 1979 | 420147 |
| phosphorylcholine antigens from nippostrongylus brasiliensis. i.--anti-phosphorylcholine antibodies in infected rats and location of phosphorylcholine antigens. | the anti-phosphorylcholine (pc) antibody synthesis was investigated in the rat after infection with the nematode nippostrongylus brasiliensis. serum igm and igg antibodies were demonstrated from day 2 or 3 post-infection. intestinal iga-antibody synthesis began shortly after the worms reached the intestine. antigens containing pc were located with the fluorescent antibody technique in l3 infective larvae, adult worms and eggs of the parasites. they were always found to internal structures such a ... | 1979 | 398680 |
| the enumeration of rat ige-secreting cells using a reverse plaque-forming cell assay. | a reverse hemolytic plaque assay utilizing protein a-coated sheep red cells and a specific rabbit anti-rat ige preparation has been adapted for the enumeration of rat ige-secreting cells derived from the ir-162 rat plasmacytoma and from rats infected with nippostrongylus brasiliensis. under optimal conditions, approximately 10-15% of the viable plasmacytoma cells were scored as plaque-forming cells. in rats infected with 5000 nippostrongylus brasiliensis larvae, a maximum of 2 x 10(6) ige-secret ... | 1979 | 387421 |
| sites of synthesis and localization of ige in rats infested with nippostrongylus brasiliensis. | the tissue and cellular localization of ige has been studied in normal rats and rats infested with the enteric parasite, nippostrongylus brasiliensis. the results of the study do not support the suggestion that ige is a secretory immunoglobulin with a physiology analogous to that of iga. the lamina propria of the small intestine and the colonic and pulmonary mucosal surfaces contain numerous anti-ige-binding cells, but these have been shown to be mast cells and not plasma cells. the major sites ... | 1977 | 346321 |
| initiation of development in vitro of third-stage nippostrongylus brasiliensis. | third-stage larvae of nippostrongylus brasiliensis were maintained in vitro in 5 different culture systems at 25 c and 37 c, and initiation of development to the parasitic phase was evaluated at the morphological and biochemical levels. a few larvae grown in krebs-ringer-tris solution at 25 c showed minimal development of the anterior region and intestinal cells. the amount of development was enhanced with an increase in medium complexity. at 25 c the greatest development was obtained in nctc-13 ... | 1979 | 448602 |
| inhibition of lymphocyte proliferation during parasitic infection with nippostrongylus brasiliensis. | | 1979 | 463665 |
| parasite fauna of the house rat rattus rattus diardii in kuala lumpur and nearby villages. | one hundred and fifty one house rats, rattus rattus diardii from five different localities, jinjang, dato keramat, kuala lumpur, sungai besi and selayang baru, were examined for parasites. nineteen species of parasites were recovered. hymenolepis diminuta and nippostrongylus brasiliensis are the predominant species. the dominancy of the parasite species in the rats differed in each locality: hymenolepis diminuta in dato keramat and kuala lumpur; nippostrongylus brasiliensis in sungai besi; gongy ... | 1979 | 483007 |
| the nature of the thymus dependency of mucosal mast cells. i. an adaptive secondary response to challenge with nippostrongylus brasiliensis. | | 1979 | 487450 |
| intestinal uptake of macromolecules. vi. uptake of protein antigen in vivo in normal rats and in rats infected with nippostrongylus brasiliensis or subjected to mild systemic anaphylaxis. | adult sprague-dawley rats weighing approximately g were fed bovine serum albumin and sodium bicarbonate by gavage. serum was obtained at intervals after feeding and tested for immunoreactive bovine serum albumin by radioimmunoassay. nanogram amounts of immunoreactive bovine serum albumin were detected in serum; peak values were obtained after 4 and 6 hr. the influence of intestinal inflammation on protein uptake was examined in two model systems. infection of rats with nippostrongylus brasiliens ... | 1979 | 488631 |
| intestinal permeability in rats infected by nippostrongylus brasiliensis. | passive intestinal permeability has been investigated in rats infected by the nematode, nippostrongylus brasiliensis, by the simultaneous administration of two probe molecules. experiments using a closed intestinal loop show that there is a significantly increased absorption of lactulose and decreased absorption of mannitol in rats at the 10th to 11th day of infection. experiments using serial oral administration techniques show that these changes start during the second week of the infection wi ... | 1979 | 488766 |
| the phospholipase b content of the intestines of sensitized rats challenged with varied larvae doses of nippostrongylus brasiliensis. | | 1979 | 489241 |
| immune regulation of intestinal goblet cell differentiation. specific induction of nonspecific protection against helminths? | goblet cell differentiation (gcd) was studied in the intestines of rats infected with nippostrongylus brasiliensis since an important component of the immune expulsion of this parasite is thought to be nonspecific. an increase in the proportion of villous goblet cells occured at the time of worm expulsion during a primary infection. gcd was augmented by the passive transfer of immune thoracic duct lymphocytes and immune serum in infected rats but not in normal controls. since drug-induced expuls ... | 1979 | 493106 |
| cytidine-5'-diphospho-choline conjugates. ii.--immunogenicity in rats. | cytidine diphospho-choline (cdpc) derivatives of human serum albumin (hsa) are immunogenic in the rat when injected in adjuvants. they induce a very rapid synthesis of igm anti-phosphorylcholine antibodies which was followed by the synthesis of anti-cdpc antibodies and of anti-hsa antibodies. the activated nucleotide was able to induce specific skin sensitivity in rats after one skin painting. gastric intubations of rats with low doses of hsa conjugates 8 days before an infection with the nemato ... | 1979 | 496401 |
| the development of infestation in rats with nippostrongylus brasiliensis (travassos 1914) exposed to microwave action. | | 1979 | 497877 |
| effect of ascaris suum and other adjuvants on the potentiation of the ige response in guinea-pigs. | the potentiation effect of various adjuvants on the production of guinea-pig ige was investigated using freund's complete and incomplete adjuvant, the lipopolysaccharide of escherichia coli and salmonella typhosa, bordetella pertussis, and the nematodes nippostrongylus brasiliensis and ascaris suum. while all the antigens had a variable effect on the potential of the igg response, only infection with a. suum resulted in an enhanced ige response to the antigen, egg albumin. maximum potentiation o ... | 1979 | 500118 |
| the phospholipase b content of the intestines of rats infected with varied larvae doses of nippostrongylus brasiliensis. | | 1979 | 500280 |
| increased permeability of gut mucosa in rats infected with nippostrongylus brasiliensis. | | 1979 | 500284 |
| changes in the structure of nippostrongylus brasiliensis intestinal cells during development from the free-living to the parasitic stages. | the ultrastructure of nippostrongylus brasiliensis intestinal cells was examined in free-living, feeding second-stage larvae, infective, nonfeeding third-stage larvae, and parasitic, feeding third-stage larvae. the intestinal cells of second-stage larvae were characterized by a well-developed microvillar border, large numbers of ribosomes, golgi complexes, rough endoplasmic reticulum, and nuclei with prominent nucleoli. the intestinal cells of infective, third-stage larvae had very few microvill ... | 1979 | 512766 |
| [blood picture of rats infected by various doses of invasive larvae of nippostrongylus brasiliensis (travassos)]. | | 1979 | 516731 |
| failure of nude (athymic) rats to become resistant to reinfection with the intestinal coccidian parasite eimeria nieschulzi or the nematode nippostrongylus brasiliensis. | the course of each of three successive infections with eimeria nieschulzi in nude (athymic) rats was the same as the primary infection in nu/+ animals, with the production of more oocysts. this indicates that resistance to reinfection with this parasite is mediated by t lymphocytes but that these cells do not control the duration of the life cycle, since oocyst production was not prolonged in the nu/nu rats. after the three infections with e. nieschulzi, the rats were exposed twice to the intest ... | 1979 | 551377 |
| [reaginic immunological responses in rats and mice]. | reaginic immunological responses present characteristics of induction which differentiate them from classical antibodies responses from other classes: among them we studied, on the one hand, the genetic control. in the case of ovo-dnp reaginic antibodies in the rat, the controls exercised by the ag-b haplotypes or the synthesis loci of the immunoglobulin heavy chains does not seem to be sufficient to explain the experimental results. another control exist probably. it could be linked to the glob ... | 1977 | 557951 |
| experimental intraperitoneal salmonella dublin infection in rats: effects of concurrent infections with fasciola hepatica and nippostrongylus brasiliensis. | | 1978 | 711936 |
| epithelia cell mitosis and morphology in worm-free regions of the intestines of the rat infected by nippostrongylus brasiliensis. | | 1978 | 722472 |
| nippostrongylus brasiliensis: age and time of day effects on pheromone production and response. | | 1977 | 558904 |
| the metabolic lesion in nippostrongylus brasiliensis induced by prostaglandin e1 in vitro. | | 1977 | 559649 |
| the location of parasites within their hosts: the behaviour of nippostrongylus brasiliensis in the anaesthetised rat. | | 1977 | 560356 |
| pairing between adults of nippostrongylus brasiliensis and other species of nematodes in vitro. | | 1977 | 560450 |
| immune mechanism of rats on nippostrongylus brasiliensis in vitro. ii. the influence of lymphocytes and peritoneal cells. | nippostrongylus were collected from the intestines of rats 6 days p.i. and kept under sterile conditions in cultures. serum, lymphocytes and peritoneal cells of immune or non-infected animals were added in various combinations to the culture media. the culture media were changed 2-3 times in an experimental period of 10 days, resp. serum and cells were added. the lymphocytes were isolated from the peripheral blood or from the mesenterial lymph nodes whereas the mononuclear cells were obtained fr ... | 1977 | 562037 |
| interactive influences of male- and female-producted pheromones on male attraction to female nippostrongylus brasiliensis. | | 1977 | 562398 |
| chemical attraction between adults of nippostrongylus brasiliensis characterization of the substance which attracts females. | | 1977 | 562399 |
| visualization of nippostrongylus brasiliensis by scanning electron microscopy. | | 1977 | 563435 |
| nippostrongylus brasiliensis: systemic and local iga and igg immunoglobulin responses in parasitized rats. | | 1977 | 563798 |
| [proceedings: compounds bearing phosphorylcholine in nippostrongylus brasiliensis: preparation and animal responses]. | | 1975 | 810070 |
| [hemagglutinating antibodies in the serum and intestinal secretions of rats infested by nippostrongylus brasiliensis]. | nippostrongylus brasiliensis infected rats responded with the formation of hemagglutinating antibodies in both serum and intestinal secretions. after the first infection seric antibody titers were quite weak but increased sharply after challenge. intestinal secretion hemagglutinines remained at constant level after both infections. this result represents a new approach in our understanding of the immune mechanism towards this parasite in rats. | 1975 | 816510 |
| suppression of reaginic antibody (ige) formation in mice by treatment with anti-mu antiserum. | neonatally initiated injection of anti-mu antiserum in mice has been shown to suppress the formation of reaginic antibodies in response to infection with the intestinal nematode, nippostrongylus brasiliensis. this observation supports the hypothesis that ige-producing cells arise from igm-bearing precursors. | 1976 | 819612 |
| ultrastructural observations on the in vitro interaction between rat eosinophils and some parasitic helminths (schistosoma mansoni, trichinella spiralis and nippostrongylus brasiliensis). | rat eosinophils form an intimate association with the surfaces of parasitic helminths, in vitro, in the presence of immune serum. the parasite presents a non-phagocytosable surface to the cell. the initial response of the eosinophil is degranulation which leads to the formation of large cytoplasmic vacuoles. peroxidase, an enzyme localized in the matrix of the crystalloid secretion granules, is discharged into these vacuoles as a consequence of degranulation. the vacuoles eventually become conne ... | 1977 | 564249 |
| nippostrongylus brasiliensis: factors influencing movement of males toward a female pheromone. | | 1978 | 564279 |
| synthesis and biological activity of some new furan quaternary salts. | a series of new n-(5-substituted 2-furfuryl)-n,n-dimethyl-n-aryloxyalkyl quaternary ammonium salts relating to general structure iv has been synthesized by reacting 5-substituted 2-(n,n-dimethylaminomethyl)furans iia-d with appropriate aryloxyalkyl bromides iii. the resulting compounds are tested for in vitro antimicrobial activity. a simpler synthesis of 5-nitro-2-(n,n-dimethylaminomethyl)furan (iid) involving the reduction of n,n-dimethyl-5-nitro-2-furamide (ib) with diborane is described. a n ... | 1977 | 833814 |
| chemical attraction between adults of nippostrongylus brasiliensis: description of the phenomenon and effects of host immunity. | attraction between adults of nippostrongylus brasiliensis was studied both in vivo and in vitro particularly with regard to the effects of host immunity on the behavior of the parasite. most worms were found in clusters in the intestines of larval-infected rats but the number of isolated worms, particularly females, was greater in 14-day (immune) than in 7-day infected (nonimmune) hosts. intubation of small numbers of normal adults into uninfected rats resulted in recovery of mostly aggregated w ... | 1977 | 558306 |
| sexual attraction and pheromonal dosage response of nippostrongylus brasiliensis. | seven-day-old male and female nippostrongylus brasiliensis exhibit mutual heterosexual attraction in vitro. a strong dosage-dependency to female pheromone was present in responding male n. brasiliensis. male helminths were significantly attracted to as few as three female worms. female helminths were less responsive to male pheromone dosage in vitro. no indication of male homosexual attraction, arrestment, or repulsion was evident. female homosexual trials suggested that an inhibition of movemen ... | 1977 | 558307 |
| changes in the adenylate energy charge of nippostrongylus brasiliensis and nematodirus battus during the development of immunity to these nematodes in their host. | infection of rats with 2000 infective juveniles of nippostrongylus brasiliensis and of lambs with 60 000 infective juveniles of nematodirus battus results in a well-marked immunity to these nematodes in their respective host. there is a fall in the adenylate energy charge value of these nematodes during the course of these infections, reaching values of 0.37 in males and 0.27 in females of n. brasiliensis, and 0.31 in males and 0.23 in females of n. battus towards the end of the infections. in h ... | 1978 | 565911 |
| enhancement of ige antibody production in akr mice. | when dinitrophenylated keyhole limpet hemocyanin (dnp-klh) primed akr mice were injected with dinitrophenylated nippostrongylus brasiliensis extract (dnp-nb), an enhancement of ige antibody production was obtained by nematode parasite, n. brasiliensis, infection or by nb antigen injection 2 weeks before dnp-nb injection. a preferential enhancement of ige production was observed in infected mice compared with nb-injected mice. anti-hapten ige antibody response was suppressed in akr mice after app ... | 1978 | 567199 |
| nippostronglylus brasiliensis infection in the rat: effect of iron and protein deficiency and dexamethasone on the efficacy of benzimidazole anthelmintics. | malnutrition, anaemia, and gut parasites are commonly interrelated. using the nippostrongylus brasiliensis-rat model, the effect of iron and protein deficiency on the efficacy of benzimidazole anthelmintics was studied. it was demonstrated that the anthelmintics mebendazole and fenbendazole were significantly less effective in eradicating parasites when animals were deficient in iron and protein. this decreased efficacy of anthelmintics in iron and protein deficiency could not be overcome by int ... | 1977 | 590849 |
| lymphocytes and eosinophils in the immune response of rats to initial and subsequent infections with nippostrongylus brasiliensis. | | 1977 | 596525 |
| nippostrongylus brasiliensis: lung mast cell populations in repeatedly inoculated rats. | | 1977 | 598445 |
| serum immunoglobulin levels in n. brasiliensis infection. | we have measured the levels of igg1, igg2a, igg2c, iga and igm in the serum of normal rats, and at various times after infection or re-infection with nippostrongylus brasiliensis, in order to compare these responses with previously measured ige levels. the results we have to report are that while the levels of the various immunoglobulin classes or subclasses are elevated to a greater or lesser extent, the increments are modest by comparison with the great elevation of total ige. | 1977 | 606448 |
| nippostrongylus brasiliensis infection in rats. the cellular requirement for worm expulsion. | the expulsion of antibody-damaged nippostrongylus brasiliensis nematodes from the intestine of rats irradiated with 750 rad 60co was induced by thoracic duct lymph (tdl) or mesenteric lymph node (mln) cells apparently without the help of bone marrow-derived cells. the effector cells were present in the tdl or mln of rats by the 8th day after infection and could be recovered from the peritoneal cavity. the ability of tdl cells to transfer immunity to irradiated recipients was undiminished when th ... | 1977 | 608681 |
| eosinophil chemotactic factor release from neutrophils by nippostrongylus brasiliensis larvae. | | 1978 | 622191 |
| the protective capacities of fractionated immune thoracic duct lymphocytes against nippostrongylus brasiliensis. | | 1978 | 657281 |
| protection against nippostrongylus brasiliensis by adoptive immunization with immune thoracic duct lymphocytes. | | 1978 | 657282 |
| suppression of rejection of nippostrongylus brasiliensis in iron and protein deficient rats: effect of syngeneic lymphocyte transfer. | rejection of nippostrongylus brasiliensis is impaired in iron and protein deficient rats and this suggests that iron and protein deficiency directly or indirectly suppresses the immune response. the site of the immunological defect in deficient rats was investigated using the technique of cellular transfer of resistance. the functional activity of immune mesenteric lymph node cells obtained from iron and protein deficient donors was not depressed as measured by their capacity to cause parasite r ... | 1978 | 710971 |
| [intensity of nippostrongylus brasiliensis (travasos, 1914) invasion in rats of different ages and strains]. | | 1978 | 726448 |
| nippostrongylus brasiliensis: peripheral blood leucocyte response of rats, with special reference to basophils. | | 1978 | 729690 |
| the location of parasites within their hosts: the passage of nippostrongylus brasiliensis through the lungs of the laboratory rat. | | 1978 | 730465 |
| nippostrongylus brasiliensis: indirect fluorescent antibody studies of immunity in mice. | | 1976 | 770184 |
| [helminths of birds and mammals from israel. vi. the taxonomy and ecology of trichostrongylid nematodes (author's transl)]. | thirteen species of trichostronglyloid nematodes have so far been recorded from wild birds and mammals in israel and surrounding territories. three species were found in birds: amidostomum fulicae (rudolphi, 1819) in fulica atra l., 1758, a. acutum (lundahl, 1848) in anas crecca l., 1758 and amidostomum sp. in ceryle rudis l., 1758. ten species, 3 of which are new, were found in small mammals: trichostrongylus colubriformis (giles, 1892) in hystrix indica kerr, 1792; tenorastrongylus josephi n. ... | 1975 | 776059 |
| ige formation in the rat following infection with nippostrongylus brasiliensis. i. proliferation and differentiation of ige-bearing cells. | | 1976 | 776414 |
| nature of cells binding anti-ige in rats immunized with nippostrongylus brasiliensis: ige synthesis in regional nodes and concentration in mucosal mast cells. | the possibility that ige is a secretory immunoglobulin has been examined by studying the tissue and cellular localization of ige in rats infested with the enteric parasite, nippostrongylus brasiliensis. the lamina propria of the small intestine and the colonic and pulmonary mucosal surfaces contained numerous anti-ige-binding cells, but these were shown to be mast cells and not plasma cells. the major site of ige synthesis was the regional lymph node of the small intestine, the mesenteric node, ... | 1976 | 789094 |
| measurement of anti-enzyme antibodies using an active-site directed radiolabel. | a new technique is described for measuring antibodies to an enzyme which is not available in pure form. the secretions of the rat parasitic nematode, nippostrongylus brasiliensis, were treated with tritiated diisopropylfluorophosphate. only one component, an acetylcholinesterase, was radiolabelled. antibodies to this enzyme in rat antisera were estimated by the farr technique using the labelled enzyme as antigen. the acetylcholinesterase secreted by necator americanus, the human hookworm, was si ... | 1976 | 792351 |
| studies on immune responses to parasite antigens in mice. iv. inhibition of an anti-dnp antibody response with the antigen, dnp-ficoll containing phosphorylcholine. | several nematode parasites contain phosphorylcholine (pc), and mice infected with ascaris suum and nippostrongylus brasiliensis produce igm anti-pc antibodies. pc is a hapten which usually induces highly restricted antibody responses in mice and the conjugate dnp-ficoll-pc inhibits an adoptive secondary anti dnp antibody response to dnp-flagellin whereas comparable doses of dnp-ficoll and ficoll-pc do not. the finding suggests that the restricted anti-pc responses to pc-containing antigens descr ... | 1976 | 797669 |
| stimulation by mitogen and metabolic antigen of dna synthesis by mesenteric lymph node and spleen cells obtained during primary infection of rats with nippostrongylus brasiliensis. | | 1977 | 832314 |
| angiostrongylus cantonensis: phospholipase in nonsensitized and sensitized rats after challenge. | rats given an initial infection with angiostrongylus cantonensis had moderately elevated phospholipase b activity in the lungs at 8 and 15 days after challenge, and greatly elevated levels were evident at 35, 43, and 49 days. in the brain, the values were elevated at 15 through 35 days. these periods of increased activity in the lungs and brain coincided with the migration patterns of the third stage larvae and the adult worms in this host. the elevated enzyme levels also were were correlated wi ... | 1977 | 832897 |
| nippostrongylus brasiliensis and trichinella spiralis: localization of lymphoblasts in the small intestine of parasitized rats. | | 1977 | 838026 |
| failure to demonstrate involvement of prostaglandins in the immune expulsion of trichostrongylus colubriformis from the intestine of guinea pigs. | the intraduodenal injection of synthetic prostaglandins did not lead to the expulsion of trichostrongylus colubriformis from the intestine of guinea pigs. treatment of immune guinea pigs with aspirin and indomethacin failed to inhibit the expulsion of a challenge infection with this nematode. these results suggest that in this infection, unlike nippostrongylus brasiliensis infection in the rat, prostaglandins do not play an important role in the immune expulsion of the parasite from the intestin ... | 1977 | 838518 |
| [characteristics of intestinal immune response of rats infected with nippostrongylus brasiliensis]. | after infection of rats with nippostrongylus brasiliensis the response was a synthesis of hemagglutinating antibodies in intestinal secretions, the activity of which is mainly due to iga. when rats were infected with 83 larvae (which is the smallest immunizing dose), local antibodies were evidenced just after parasite localization had occurred in the gut, whereas serum antibodies were not detected before a challenge infection. some of these local antibodies were directed against two types of wor ... | 1977 | 848881 |
| the location of parasites within their hosts: the influence of surgical manipulation of the intestine and mesenteric blood supply on the dispersion of nippostrongylus brasiliensis in the rat. | | 1977 | 858652 |
| ige formation in the rat after infection with nippostrongylus brasiliensis. ii. proliferation of ige-bearing cells in neonatally thymectomized animals. | | 1977 | 864253 |
| suppression of ige antibody production in sjl mice. iii. characterization of a suppressor substance extracted from normal sjl spleen cells. | sjl mice were immunized with 1 microng dinitrophenylated keyhole limpet hemocyanin in 1 mg al(oh)3. the mice were infected 21 days later with 750 third stage larvae of nippostrongylus brasiliensis. on day 35, 14 days after infection, they were injected with 1 microng dnp-n, brasiliensis extract (nb) in 1 mg al(oh)3. in order to obtain high titer and persistent anti-dnp ige antibody the mice were irradiated (540 r) 1 day after injection of dnp-nb. suppression of anti-dnp ige antibody production w ... | 1977 | 864380 |
| intestinal absorption of hexoses in rats infected with nippostrongylus brasiliensis. | | 1977 | 873686 |
| scanning electron microscopy of the jejunum of the rat infected by the nematode nippostrongylus brasiliensis. | | 1976 | 944168 |
| nippostrongylus brasiliensis: further studies of the relation between host immunity and worm acetylcholinesterase levels. | | 1976 | 944170 |
| nippostrongylus brasiliensis in mice: reduction of worm burden and prolonged infection induced by presence of nematospiroides dubius. | | 1976 | 945339 |