| thunberginols c, d, and e, new antiallergic and antimicrobial dihydroisocoumarins, and thunberginol g 3'-o-glucoside and (-)-hydrangenol 4'-o-glucoside, new dihydroisocoumarin glycosides, from hydrangeae dulcis folium. | new antiallergic and antimicrobial dihydroisocoumarins, thunberginols c, d, and e, were isolated from hydrangeae dulcis folium, the fermented and dried leaves of hydrangea macrophylla seringe var. thunbergii makino, together with new dihydroisocoumarin glycosides, thunberginol g 3'-o-glucoside and (-)-hydrangenol 4'-o-glucoside. their chemical structures have been determined on the basis of chemical and physicochemical evidence. thunberginols c, d, e, g, and (-)-hydrangenol 4'-o-glucoside showed ... | 1992 | 1363465 |
| thunberginols a, b, and f, new antiallergic and antimicrobial principles from hydrangeae dulcis folium. | six new antiallergic and antimicrobial principles, thunberginols a, b, c, d, e, and f, were isolated from hydrangeae dulcis folium, the fermented and dried leaves of hydrangea macrophylla seringe var. thunbergii makino. the chemical structures of thunberginols a, b, and f have been determined on the basis of chemical and physiocochemical evidence. thunberginols a, b, and f showed more potent antiallergic activity than phyllodulcin, hydrangenol, and aa-861 in the in vitro test using the schults-d ... | 1992 | 1477932 |
| [electron microscopic demonstration of mycoplasma-like organisms in phloem of hydrangea macrophylla]. | | 1971 | 5172502 |
| [development of bioactive functions in hydrangeae dulcis folium. ii. antiulcer, antiallergy, and cholagoic effects of the extract from hydrangeae dulcis folium]. | in order to develop new bioactive functions of hydrangeae dulcis folium, the fermented and dried leaves of hydrangea macrophylla seringe var. thunbergii makino, effects of the methanolic extract from the crude drug on antiucler, antiallergic, cholagoic, and various pharmacological actions were investigated. consequently, the methanolic extract was found to exhibit potent antiulcer, antiallergic, and cholagoic activities. by monitoring with these activities, it was found that the active constitue ... | 1994 | 7519675 |
| absolute stereostructures of hydramacrosides a and b, new bioactive secoiridoid glucoside complexes from the leaves of hydrangea macrophylla seringe var. thunbergii makino. | two new bioactive secoiridoid glucoside complexes named hydramacrosides a and b were isolated from the leaves of hydrangea macrophylla seringe var. thunbergii makino. the absolute stereostructures of hydramacrosides a and b were elucidated on the basis of chemical and physicochemical evidence which included the application of the 13c nmr glycosylation shift rule of 1, 1'-disaccharides and the modified mosher's method. hydramacrosides a and b exhibited inhibitory effect on the histamine release f ... | 1994 | 7525087 |
| development of bioactive functions in hydrangeae dulcis folium. iii. on the antiallergic and antimicrobial principles of hydrangeae dulcis folium. (1). thunberginols a, b, and f. | from the less polar fraction of hydrangeae dulcis folium, the fermented and dried leaves of hydrangea macrophylla seringe var. thunbergii makino, eight antiallergic and antimicrobial principles were isolated together with several known compounds. among the newly isolated bioactive constituents, the chemical structures of thunberginols a, b, and f have been determined on the basis of chemical and physicochemical evidence. thunberginols a, b, and f were found to exhibit more potent antiallergic ac ... | 1994 | 7532114 |
| [quantitative analysis of dihydroisocoumarin constituents of hydrangeae dulcis folium by means of high performance liquid chromatography. chemical characterization of the processing, distribution in plant, and seasonal fluctuation]. | in order to characterize the chemical change of the constituents during the processing of hydrangeae dulcis folium, quantitative analyses of phyllodulcin, hydrangenol, and their 8-o-glucosides were developed by means of high performance liquid chromatography. as an application of this hplc method, the distribution of those dihydroisocoumarins in different parts of hydrangea macrophylla var. thunbergii was investigated. it was found that these dihydroisocoumarins were contained at the highest con ... | 1994 | 8189355 |
| development of bioactive functions in hydrangeae dulcis folium. v. on the antiallergic and antimicrobial principles of hydrangeae dulcis folium. (2). thunberginols c, d, and e, thunberginol g 3'-o-glucoside, (-)-hydrangenol 4'-o-glucoside, and (+)-hydrangenol 4'-o-glucoside. | following the characterization of thunberginols a, b, and f, six bioactive principles, thunberginols c, d, and e, thunberginol g 3'-o-glucoside, (-)-hydrangenol 4'-o-glucoside, and (+)-hydrangenol 4'-o-glucoside, were isolated from hydrangeae dulcis folium, the processed leaves of hydrangea macrophylla seringe var. thunbergii makino, together with four kaempferol and quercetin oligoglycosides. their chemical structures have been determined on the basis of chemical and physicochemical evidence. t ... | 1996 | 8795265 |
| p-coumaroyltriacetic acid synthase, a new homologue of chalcone synthase, from hydrangea macrophylla var. thunbergii. | chalcone synthase and stilbene synthase are plant-specific polyketide synthases. they catalyze three common consecutive decarboxylative condensations and specific cyclization reactions. they are highly homologous to each other, and are likely to fall into a family of polyketide synthases along with acridone synthase and bibenzyl synthase. two cdna clones (named hmc and hms), both of which show high homology to the known chalcone synthases, were obtained from leaves of hydrangea macrophylla var. ... | 1999 | 10469148 |
| effects of phyllodulcin, hydrangenol, and their 8-o-glucosides, and thunberginols a and f from hydrangea macrophylla seringe var. thunbergii makino on passive cutaneous anaphylaxis reaction in rats. | we examined the antiallergic effects of phyllodulcin, hydrangenol, and their 8-o-glucosides, and thunberginols a and f isolated from the processed leaves (hydrangeae dulcis folium) and dried leaves of hydrangea macrophylla seringe var. thunbergii makino using the passive cutaneous anaphylaxis (pca) reaction. with the exception of phyllodulcin, these constituents were found to significantly inhibit the pca reaction. although thunberginol a showed the most potent inhibitory effect, hydrangenol was ... | 1999 | 10480329 |
| chemical constituents from the leaves of hydrangea macrophylla var. thunbergii (iii): absolute stereostructures of hydramacrosides a and b, secoiridoid glucoside complexes with inhibitory activity on histamine release. | following the characterization of dihydroisocoumarin constituents, two secoiridoid glucoside complexes, called hydramacrosides a and b, were isolated from the leaves of hydrangea macrophylla seringe var. thunbergii makino. the absolute stereostructures of hydramacrosides a and b were elucidated on the basis of chemical and physicochemical evidence, which included the application of the 13c-nmr glycosylation shift rule of 1,1'-disaccharides and the modified mosher's method. hydramacrosides a and ... | 1999 | 10748718 |
| anti-malarial activity of leaf-extract of hydrangea macrophylla, a common japanese plant. | to find a new anti-malarial medicine derived from natural resources, we examined the leaves of 13 common japanese plants in vitro. among them, a leaf-extract of hydrangea macrophylla, a common japanese flower, inhibited the parasitic growth of plasmodium falciparum. the ic50 of hydrangea macrophylla leaf extract to plasmodium falciparum was 0.18 microg/ml. the ic50 to nih 3t3-3 cells, from a normal mouse cell line, was 7.2 microg/ml. thus, selective toxicity was 40. for the in vivo test, we inoc ... | 2000 | 11061572 |
| a potent antimalarial activity of hydrangea macrophylla var. otaksa leaf extract against plasmodium yoelii 17xl in mice. | the antimalarial activity of the hot-water extract of hydrangea macrophylla var. otaksa leaves was evaluated against plasmodium yoelii 17xl in mice. non-treated control mice died from 6 to 7 days after infection, but mice treated with the leaf extract survived during the experiment. mice given the extract orally showed low parasitemia levels during administration. following a transient recrudescence of malaria parasites in the bloodstream of treated mice, no parasites could be detected by a micr ... | 2001 | 11267930 |
| comparison of antimalarial activity of the alkaloidal fraction of hydrangea macrophylla var. otaksa leaves with the hot-water extract in icr mice infected with plasmodium yoelii 17 xl. | the antimalarial activity of the fractions isolated from the leaves of hydrangea macrophylla seringe var. otaksa makino was evaluated against plasmodium yoelii 17 xl in mice. four different fractions were prepared in the usual manner to obtain an alkaloid fraction. all mice treated with the fraction containing febrifugine and isofebrifugine mixture at 1 mg/kg twice a day for 5 consecutive days survived during the experiment, and the change of mean parasitemia level showed almost the same pattern ... | 2003 | 12820231 |
| different responses of three rodent plasmodia species, plasmodium yoelii 17xl, p. berghei nk65 and p. chabaudi as on treatment with febrifugine and isofebrifugine mixture from hydrangea macrophylla var. otaksa leaf in icr mice. | the antimalarial activity of hydrangea macrophylla var. otaksa alkaloids was evaluated against plasmodium yoelii 17xl, p. berghei nk65 and p. chabaudi as in icr mice. for trials in p. yoelii 17xl or p. chabaudi as infections, mice were infected intraperitoneally with 10(5), 10(6) and 10(7) parasitized erythrocytes, respectively, and in p. berghei nk65 infections, mice were infected intraperitoneally with 10(3), 10(4) and 10(5) parasitized erythrocytes, respectively. three days after injection, m ... | 2003 | 12820234 |
| a potential suppressor of tgf-beta delays catagen progression in hair follicles. | tgf-beta plays important roles in the induction of catagen during the hair cycle. we examined whether tgf-beta2 could activate a caspase in human hair follicles. using active caspase-9 and -3 specific antibodies, we found that tgf-beta2 activated these caspases in two regions, the lower part of the hair bulb and the outer layer of the outer root sheath. in addition, we searched for a plant extract that can effectively suppress tgf-beta action. we found that an extract of hydrangea macrophylla re ... | 2003 | 12894996 |
| suppression by hydrangeae dulcis folium of d-galactosamine-induced liver injury in vitro and in vivo. | hydrangeae dulcis folium, the fermented and dried leaves of hydrangea macrophylla ser. var. thunbergii makino, suppressed d-galactosamine-induced liver injury by 85.2% when added to the diet at 1% and fed to rats for fifteen days. the hepatoprotective effect is more potent than that of a milk thistle extract and turmeric powder. some fractionated extracts showed hepatoprotective activity in the d-galactosamine-induced in vitro liver injury model. | 2003 | 14730144 |
| cytokine and antibody production during the course of resolution in plasmodium yoelii 17xl-infected balb/c mice treated with febrifugine and isofebrifugine mixture from leaves of hydrangea macrophylla var. otaksa. | cytokine and antibody production was investigated during the course of resolution of primary infection in plasmodium yoelii 17xl-infected balb/c mice treated with a mixture of febrifugine and isofebrifugine. the infected mice in an untreated control group showed a progressively increasing parasitemia, leading to mouse death. in contrast, infected mice given the mixture orally showed low parasitemia levels during administration. following a transient increase in parasitemia in the bloodstream of ... | 2004 | 15338283 |
| new and remarkable microfungi in north rhine westphalia, germany. | during our investigation on microfungi in north rhine westphalia in the years 2002 and 2003 we were able to collect and identify some new and rare species of microfungi as parasites and saprophytes on wild and ornamental plants. some of these like erysiphe elevata (burill.) u. braun & s. takamatsu comb. nov. [=microsphaera elevata burill.] on catalpa bignonioides walt., erysiphe syringae-japonicae (u. braun) u. braun & s. takamatsu [= microsphaera syringae-japonicae u. braun, m. aceris bunkina. ... | 2004 | 15756829 |
| inhibitory effects of thunberginols a, b, and f on degranulations and releases of tnf-alpha and il-4 in rbl-2h3 cells. | thunberginols a, b, and f from the processed leaves of hydrangea macrophylla var. thunbergii (hydrangeae dulcis folium) substantially inhibited the degranulations by antigen and calcium ionophore a23187, and the releases of tnf-alpha and il-4 by antigen in rbl-2h3 cells. phyllodulcin and hydrangenol also showed significant inhibition for the antigen-induced degranulations, but their effects were weaker than those of thunberginols a, b, and f. among them, thunberginol b showed the most potent act ... | 2007 | 17268088 |
| new type of anti-diabetic compounds from the processed leaves of hydrangea macrophylla var. thunbergii (hydrangeae dulcis folium). | two 3-phenyldihydroisocoumarins (hydrangenol and phyllodulcin), a 3-phenylisocoumarin (thunberginol a), and a stilbene (hydrangeaic acid) from the processed leaves of hydrangea macrophylla var. thunbergii (hydrangeae dulcis folium) promoted adipogenesis of 3t3-l1 cells. hydrangenol, a principal constituent, significantly increased the amount of adiponectin released into the medium and mrna levels of adiponectin, peroxisome proliferator-activated receptor gamma2 (ppargamma2), and glucose transpor ... | 2007 | 17609121 |
| synthesis of 3-substituted isocoumarins and their inhibitory effects on degranulation of rbl-2h3 cells induced by antigen. | eleven 3-substituted isocoumarins and a benzylidenephthalide were synthesized through thermal cyclization reaction of delta- and gamma-ketoamides, respectively. subsequent deprotection of the hydroxyl groups of the resulting isocoumarin and benzylidenephthalide compounds afforded thunberginols a, b, and f, respectively, which originated from the processed leaves of hydrangea macrophylla seringe var. thunbergii makino. the synthesized isocoumarins and thunberginols were evaluated for their anti-a ... | 2008 | 18758098 |
| phenotypical differences among b. cinerea isolates from ornamental plants. | b. cinerea is a common pathogenic fungus which causes botrytis blight (grey mould) in most ornamental plants. it may be responsible for serious preharvest diseases and postharvest losses in fruits, vegetables and flowers. in this work, several b. cinerea isolates from ornamental plants (chamelaucium uncinatum, pelargonium x hortorum, euphorbia pulcherrima, lantana camara, lonicera japonica, hydrangea macrophylla, and cyclamen persicum) affected by botrytis blight in the south of spain were studi ... | 2008 | 19226749 |
| hydrangeic acid from the processed leaves of hydrangea macrophylla var. thunbergii as a new type of anti-diabetic compound. | hydrangeic acid (3-100 microm), a stilbene constituent of the processed leaves of hydrangea macrophylla var. thunbergii (hydrangeae dulcis folium), promoted adipogenesis of 3t3-l1 cells. hydrangeic acid significantly increased the amount of adiponectin released into the medium, the uptake of 2-deoxyglucose into the cells, and the translocation of glucose transporter 4 (glut4). hydrangeic acid also increased mrna levels of adiponectin, peroxisome proliferator-activated receptor gamma2 (ppargamma2 ... | 2009 | 19374876 |
| temperature-dependent growth of botrytis cinerea isolates from potted plants. | botrytis cinereo is a common aggressive saprophyte fungus which also invades injured plant tissues, causing botrytis blight (grey mould) in many ornamental plants, including potted flowering plants. several b. cinerea isolates from potted plants (pelargonium x hortorum, lantana camara, lonicera japonica, hydrangea macrophylla, and cyclamen persicum) affected by botrytis blight in the south of spain were studied and identified by pcr. the isolates showed phenotypic differences between them, as pr ... | 2009 | 20222557 |
| effects of paclobutrazol on botrytis cinerea isolates obtained from potted plants. | the growth of different isolates of botrytis cinerea, collected from potted plants affected by botrytis blight in southern spain during recent years, was studied. these isolates, which show wide phenotypic differences when grown in vitro, are differentially affected by growth temperature, gibberellic acid, and paclobutrazol--an efficient plant growth retardant used widely in nursery potted plants to reduce plant size, favouring compactness, a more intense green foliage and increased stress toler ... | 2010 | 21534481 |
| search for antidiabetic constituents of medicinal food. | many foods are known to have not only nutritive and taste values but also medicinal effects. in chinese traditional medicine, the treatment using medicinal foods has been recommended highly. recently, we examined the effects of the extract and constituents of several medicinal foods on experimental models of diabetes. in this paper, we focus on the bioactive constituents of four medicinal foods, namely the antidiabetic constituents from 1) the roots, stems and leaves of salacia plants, 2) the ma ... | 2011 | 21628977 |
| effects of indole-3-acetic acid on botrytis cinerea isolates obtained from potted plants. | we study the growth of different isolates of botrytis cinerea collected from potted plants which were affected by botrytis blight in southern spain during recent years. these isolates, which show widely phenotypic differences when grown in vitro, are differentially affected by growth temperature, gibberellic acid applications and paclobutrazol, an efficient plant growth retardant and fungicide at the same time. in this work, we have evaluated the effect of the auxin indole-3-acetic acid (iaa) do ... | 2011 | 22702183 |
| comparison of diagnostic techniques for the detection and differentiation of cherry leaf roll virus strains for quarantine purposes. | some strains of cherry leaf roll virus (clrv) are considered as quarantine pests in new zealand. clrv was detected in seven plant host species: actinidia chinensis, hydrangea macrophylla, malus domestica, plantago major, ribes rubrum, rubus idaeus and rumex sp. collected from new zealand between 2005 and 2012. biological, serological and molecular techniques were compared for the detection and differentiation of clrv isolates. the biological analysis revealed differences in symptomatology and di ... | 2016 | 27129669 |
| tonoplast- and plasma membrane-localized aquaporin-family transporters in blue hydrangea sepals of aluminum hyperaccumulating plant. | hydrangea (hydrangea macrophylla) is tolerant of acidic soils in which toxicity generally arises from the presence of the soluble aluminum (al) ion. when hydrangea is cultivated in acidic soil, its resulting blue sepal color is caused by the al complex formation of anthocyanin. the concentration of vacuolar al in blue sepal cells can reach levels in excess of approximately 15 mm, suggesting the existence of an al-transport and/or storage system. however, until now, no al transporter has been ide ... | 2012 | 22952644 |
| preventive control of aphids in ornamental plants with complementary parasitoids. | biological control of aphids can be achieved with parasitoids. a parasitoid is a wasp able to parasitize aphids in a host-specific way. these natural enemies of aphids are used in organic or integrated pest management strategies. in order to apply the matching parasitoid against a given aphid species, the aphid has to be detected in the crop and subsequently identified. by the time the aphids are spotted by the grower and then identified by himself or a specialist, it is usually more difficult t ... | 2012 | 23885420 |
| plant poisoning in domestic animals: epidemiological data from an italian survey (2000-2011). | an italian epidemiological study based on the human poison control centre of milan (centro antiveleni di milano (cav)) data related to domestic animal poisoning by exposure to plants, was carried out in collaboration with the veterinary toxicology section of the university of milan. it encompasses a 12-year period, from the beginning of 2000 to the end of 2011. calls related to toxic plants accounted for 5.7 per cent of total inquiries (2150) received by cav. the dog was the most commonly poison ... | 2013 | 23716536 |
| a new species of the genus <i>thrips</i> (thysanoptera: thripidae) from the western ghats of india. | thrips laurencei sp.n. is described from specimens collected on flowers of hydrangea macrophylla in western ghats range of tamil nadu, india. this new species shows sexual dimorphism in colour, with the females brownish yellow with brown shadings but the males uniformly yellow. | 2017 | 28187653 |