| screening of indigenous plants for anthelmintic action against human ascaris lumbricoides: part--ii. | alcoholic extracts of the rhizomes of alpinia galanga, andrographis paniculata, bark of cinnamomum zeylanicum, rind of citrus decumana, desmodium triflorum, seeds of hydnocarpus wightiana, rhizomes of kaempfaria galanga, lippia nodiflora, tender leaves of morinda citrifolia, rhizomes of pollia serzogonian, tephrosia purpuria and rhizomes of zingiber zerumbeth showed good in vitro anthelmintic activity against human ascaris lumbricoides. while, the alcoholic extracts of the bark of alibzzia lebbe ... | 1975 | 1158424 |
| [growth inhibition of entamoeba histolytica and e. invadens produced by pomegranate root (punica granatum l.)]. | the purpose of the present work has been to evaluate the biological activity of alkaloids and tannins extracted from roots of punica granatum l. on axenic cultures from entamoeba histolytica and e. invadens, strains. initially, the total aqueous extract and later some of its components obtained by thin layer chromatography were tested. these compounds were identified by chromatography as alkaloids or tannins. the density of amebic cultures was determined with a hemocytometer after 48 and 96 hour ... | 1990 | 2131771 |
| anti-implantation activity of some indigenous plants in rats. | various extracts of one hundred and eight medicinal plants were screened for their anti-implantation activity in female albino rats. out of these, 50% ethanolic extract of codonospis ovata benth (pl); 50% ethanolic, acetone and benzene extracts of puararia tuberosa dc (tub); aqueous and methanolic extracts of punica granatum linn. (px) and ethanolic and acetone extracts of rubus ellipiticus smith (px) inhibited pregnancy in 70-90% of rats. similarly ethanolic extract of adhatoda vasica nees (lf) ... | 1985 | 3832714 |
| [in vitro effect against giardia of 14 plant extracts]. | to investigate antigiardiasic activity in plants used in mexico as antidiarrheics and/or antiparasitics. | 1994 | 7839013 |
| in vitro antibacterial activity of argentine folk medicinal plants against salmonella typhi. | boiling water extracts of 132 samples from 54 plant families, commonly used in argentine folk medicine, were screened for antibacterial activity against salmonella typhi. the agar-well diffusion method was used. a reference concentration-response curve for ampicillin was used to estimate the apparent activity of the samples. twenty four species showed antibacterial activity. cassia occidentalis roots, heimia salicifolia aerial parts, punica granatum fruit pericarp and rosa borboniana flowers pro ... | 1994 | 7990503 |
| [the in vitro action of plants on vibrio cholerae]. | natural products of several plants, according to the geographic location, are used by peruvian people in the popular treatment of diarrhea, with good success. when cholerae cases appeared in peru, we were interested to know the "in vitro" effect against vibrio cholerae 01, of these useful plants to treat diarrhea. the following plants were tested: cichorium intybus, althaea officinalis, psorela glandulosa, geranium maculatum, punica granatum, malus sativa, cydonia oblonga, chenopodium ambrosoide ... | 1994 | 8018898 |
| carbonic anhydrase inhibitors from the pericarps of punica granatum l. | seven highly active inhibitors against carbonic anhydrase (ca, ec 4.2.1.1), punicalin (2), punicalagin (3), granatin b (5), gallagyldilactone (7), casuarinin (8), pedunculagin (9) and tellimagrandin i (10), and four weakly active inhibitors, gallic acid (1), granatin a (4), corilagin (6) and ellagic acid (11), were isolated from the pericarps of punica granatum l. (punicaceae). they are ellagitannins. the type of inhibition by 3 and 7 using p-nitrophenyl acetate as a substrate, is noncompetitive ... | 1993 | 8220326 |
| screening of plants used in argentine folk medicine for antimicrobial activity. | screening of 132 extracts from argentine folk-medicinal plants for antimicrobial activity has been conducted using a penicillin g resistant strain of staphylococcus aureus, escherichia coli and aspergillus niger as test microorganisms. cephazolin, ampicillin and miconazole were used as standard antibiotics and concentration-response curves were obtained using the agar-well diffusion method. boiling water extracts of plant materials were tested and 12 species were active against staphylococcus au ... | 1993 | 8412245 |
| [antiviral activity of tannin from the pericarp of punica granatum l. against genital herpes virus in vitro]. | based on cell culture techniques this study has demonstrated that tannin from the pericarp of punica granatum is an effective component against genital herpes virus (hsv-2). the tannin not only inhibits hsv-2 replication, but also shows stronger effects of killing virus and blocking its absorption to cells. | 1995 | 8679095 |
| antimicrobial evaluation of some plants used in mexican traditional medicine for the treatment of infectious diseases. | twelve methanolic plant extracts from botanical species used in traditional medicine in morelos, méxico to cure infectious diseases have been subjected to a screening study to detect potential antimicrobial activity against staphylococcus aureus, escherichia coli, pseudomonas aeruginosa and candida albicans. the antimicrobial activity of the products was evaluated using colonies growing in solid medium, establishing the minimal concentration required to inhibit their in vitro growth (mic). the r ... | 1996 | 8887021 |
| antifungal activity of indian plant extracts. | in vitro studies of water extracts of plants such as terminalia chebula, punica granatum, delonix regia and emblica officinalis were found to be detrimental to test dermatophytes. | 1998 | 9919899 |
| effects of quercus ilex l. and punica granatum l. polyphenols against ethanol-induced gastric damage in rats. | | 1999 | 9987803 |
| effects of aqueous extracts from quercus ilex l. root bark, punica granatum l. fruit peel and artemisia herba-alba asso leaves on ethanol-induced gastric damage in rats. | the gastroprotective effect of tannic acid and the aqueous extract of quercus ilex l. root bark, punica granatum l. fruit peel and artemisia herba-alba asso leaves was investigated in the rat against ethanol-induced damage. tannic acid, q. ilex and p. granatum extracts gave 100% precipitation of ovine haemoglobin in vitro, whereas a. herba-alba extract was devoid of any protein-binding property. oral administration of these plant extracts or tannic acid induced a significant decrease in gastric ... | 1999 | 10189949 |
| antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids. | the antioxidant and eicosanoid enzyme inhibition properties of pomegranate (punica granatum) fermented juice and seed oil flavonoids were studied. the pomegranate fermented juice (pfj) and cold pressed seed oil (pcpso) showed strong antioxidant activity close to that of butylated hydroxyanisole (bha) and green tea (thea sinensis), and significantly greater than that of red wine (vitis vitifera). flavonoids extracted from pcpso showed 31-44% inhibition of sheep cyclooxygenase and 69-81% inhibitio ... | 1999 | 10432202 |
| studies on antidiarrhoeal activity of punica granatum seed extract in rats. | methanol extract of punica granatum seed was evaluated for antidiarrhoeal activity against different experimental models of diarrhoea in rats. p. granatum seed extract treated animals showed significant inhibitory activity against castrol-oil induced diarrhoea and pge2 induced enteropooling in rats. the extract also showed a significant reduction in gastro-intestinal motility in charcoal meal test in rats. the results obtained established the efficacy of p. granatum seed extract as an antidiarrh ... | 1999 | 10624879 |
| effect of punica granatum linn. (flowers) on blood glucose level in normal and alloxan-induced diabetic rats. | 'gulnar farsi', male abortive flowers of punica granatum l., are used for the treatment of diabetes mellitus in unani medicine. oral administration of its aqueous-ethanolic (50%, v/v) extract led to significant blood glucose lowering effect in normal, glucose-fed hyperglycaemic and alloxan-induced diabetic rats. this effect of the extract was maximum at 400 mg/kg, b.w. | 2000 | 10837992 |
| effect of certain plant extracts on alpha-amylase activity. | ethanolic extracts of punica granatum, mangifera indica, boerhaavia diffusa, embelia ribes, phyllanthus maderaspatensis, and withania somnifera, were tested for their effect on alpha-amylase activity (in vitro). p. granatum and m. indica were found to exhibit interesting alpha-amylase inhibitory activity. | 2001 | 11223231 |
| immunomodulatory activity of punica granatum in rabbits--a preliminary study. | punica granatum l. (punicaceae) fruit rind powder (pgfrp) at the dose of 100 mg/kg orally as aqueous suspension was found to stimulate the cell-mediated and humoral components of the immune system in rabbits. pgfrp elicited an increase in antibody titer to typhoid-h antigen. it also enhanced the inhibition of leucocyte migration in leucocyte migration inhibition test and induration of skin in delayed hypersensitivity test with purified protein derivative (ppd) confirming its stimulatory effect o ... | 2001 | 11585693 |
| studies on the hypoglycaemic activity of punica granatum seed in streptozotocin induced diabetic rats. | the hypoglycaemic activity of punica granatum linn. (family punicaceae) seed extract on rats made diabetic by streptozotocin (stz) was investigated. the methanol extract of the seed at doses of 300 and 600 mg/kg, and chlorpropamide 200 mg/kg was administered to stz diabetic rats. the seed extract (150, 300 and 600 mg/kg, orally) caused a significant reduction of blood glucose levels in stz induced diabetic rats by 47% and 52%, respectively, at the end of 12 h. | 2001 | 11746848 |
| studies on the antioxidant activity of pomegranate (punica granatum) peel and seed extracts using in vitro models. | antioxidant-rich fractions were extracted from pomegranate (punica granatum) peels and seeds using ethyl acetate, methanol, and water. the extracts were screened for their potential as antioxidants using various in vitro models, such as beta-carotene-linoleate and 1,1-diphenyl-2-picryl hydrazyl (dpph) model systems. the methanol extract of peels showed 83 and 81% antioxidant activity at 50 ppm using the beta-carotene-linoleate and dpph model systems, respectively. similarly, the methanol extract ... | 2002 | 11754547 |
| antioxidant activities of pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin, and pelargonidin. | antioxidant activities of freeze-dried preparations of a 70% acetone extract of pomegranate (punica granatum l.) and its three major anthocyanidins (delphinidin, cyanidin, and pelargonidin) were evaluated. free radical scavenging activities were examined using an esr technique with spin trapping; dmpo for hydroxyl (.oh) and superoxide (o(2)(.-) ) radicals; and [(mgd)(2)fe(2+)] for nitric oxide (no). inhibitory effects on lipid peroxidation were estimated by the levels of malonaldehyde and 4-hydr ... | 2002 | 11754562 |
| chemopreventive and adjuvant therapeutic potential of pomegranate (punica granatum) for human breast cancer. | fresh organically grown pomegranates (punica granatum l.) of the wonderful cultivar were processed into three components: fermented juice, aqueous pericarp extract and cold-pressed or supercritical co2-extracted seed oil. exposure to additional solvents yielded polyphenol-rich fractions ('polyphenols') from each of the three components. their actions, and of the crude whole oil and crude fermented and unfermented juice concentrate, were assessed in vitro for possible chemopreventive or adjuvant ... | 2002 | 12002340 |
| studies on antioxidant activity of pomegranate (punica granatum) peel extract using in vivo models. | pomegranate (punica granatum) peel extracts have been shown to possess significant antioxidant activity in various in vitro models. dried pomegranate peels were powdered and extracted with methanol for 4 h. the dried methanolic extract was fed to albino rats of the wistar strain, followed by carbon tetrachloride (ccl4), and the levels of various enzymes, such as catalase, peroxidase, and superoxide dismutase (sod), and lipid peroxidation were studied. treatment of rats with a single dose of ccl4 ... | 2002 | 12166961 |
| delta 12-oleate desaturase-related enzymes associated with formation of conjugated trans-delta 11, cis-delta 13 double bonds. | conjugated linolenic acids are present as major seed oils in several plant species. punicic acid (or trichosanic acid) is a conjugated linolenic acid isomer containing cis-delta9, trans-delta11, cis-delta13 double bonds in the c(18) carbon chain. here we report cdnas, tkfac and pgfac, isolated from trichosanthes kirilowii and punica granatum, that encode a class of conjugases associated with the formation of trans-delta11, cis-delta13 double bonds. expression of tkfac and pgfac in arabidopsis se ... | 2003 | 12464604 |
| screening of some plants used in the brazilian folk medicine for the treatment of infectious diseases. | extracts of 13 brazilian medicinal plants were screened for their antimicrobial activity against bacteria and yeasts. of these, 10 plant extracts showed varied levels of antibacterial activity. piper regnellii presented a good activity against staphylococus aureus and bacillus subtilis, a moderate activity on pseudomonas aeruginosa, and a weak activity against escherichia coli. punica granatum showed good activity on s. aureus and was inactive against the other standard strains. eugenia uniflora ... | 2002 | 12471432 |
| plant antimutagens and their mixtures in inhibition of genotoxic effects of xenobiotics and aging processes. | the antimutagenic effect of the bioactive compounds from fruits of morus alba l. (ma), punica granatum l. (pg), diospyros kaki l. (dk), cydonia oblonga mill. (co) and roots of glycyrrhiza glabra (gg) were investigated. the antimutagenic effects of compounds separately as well as their action in complex mixtures were studied on mutations induced by genotoxicants (x-rays, n-methylnitrosourea, cyclophosphamide, naf) and aging in bone marrow cell chromosomes from mice and rats. when tested separatel ... | 2002 | 12570329 |
| in vitro activity of brazilian medicinal plants, naturally occurring naphthoquinones and their analogues, against methicillin-resistant staphylococcus aureus. | fourteen extracts from brazilian traditional medicinal plants used to treat infectious diseases were used to look for potential antimicrobial activity against multiresistant bacteria of medical importance. staphylococcus aureus strains were susceptible to extracts of punica granatum and tabebuia avellanedae. the minimum inhibitory concentrations (mics) of the total extracts and of additional fractions of these plants were determined by employing strains of methicillin-resistant (mrsa) and -sensi ... | 2003 | 12636992 |
| assessment of the effect of punica granatum (pomegranata) on the bioavailability of the radiopharmaceutical sodium pertechnetate (99mtc) in wistar rats. | the many desirable characteristics of technetium-99m (99mtc) have stimulated the development of labeling techniques for different molecular and cellular structures. it is generally accepted that a variety of factors other than disease can alter the bioavailability of radiopharmaceuticals and one such factor is the drug therapy. the use of medicinal plants has increased in the last decades all over the world. punica granatum (pomegranata) is used as food or as medication in folk medicine for anti ... | 2003 | 12899440 |
| studies on the toxicity of punica granatum l. (punicaceae) whole fruit extracts. | current investigation focuses on the toxicity evaluation of whole fruit hydroalcoholic extract of punica granatum l. (punicaceae), used in cuban traditional medicine a.o. for the treatment of respiratory diseases. previous findings on the anti-influenza activity of punica granatum extracts has given support to the ethnopharmacological application. in our study, in chick embryo model, it was found that doses of the extract of less than 0.1 mg per embryo are not toxic. the ld50 of the extract, det ... | 2003 | 14611895 |
| rapid dereplication of estrogenic compounds in pomegranate (punica granatum) using on-line biochemical detection coupled to mass spectrometry. | during recent years, phytoestrogens have been receiving an increasing amount of interest, as several lines of evidence suggest a possible role in preventing a range of diseases, including the hormonally dependent cancers. in this context, various parts of the pomegranate fruit (punica granatum; punicaceae), e.g. seed oil, juice, fermented juice and peel extract, have been shown to exert suppressive effects on human breast cancer cells in vitro. on-line biochemical detection coupled to mass spect ... | 2004 | 14732284 |
| differentiation-promoting activity of pomegranate (punica granatum) fruit extracts in hl-60 human promyelocytic leukemia cells. | differentiation refers to the ability of cancer cells to revert to their normal counterparts, and its induction represents an important noncytotoxic therapy for leukemia, and also breast, prostate, and other solid malignancies. flavonoids are a group of differentiation-inducing chemicals with a potentially lower toxicology profile than retinoids. flavonoid-rich polyphenol fractions from the pomegranate (punica granatum) fruit exert anti-proliferative, anti-invasive, anti-eicosanoid, and pro-apop ... | 2004 | 15117547 |
| pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. | pomegranate (punica granatum l.) seed oil (pgo) contains more than 70% cis(c)9,trans(t)11,c13-18:3 as conjugated linolenic acids (cln). our previous short-term experiment demonstrated that seed oil from bitter melon (momordica charantia) (bmo), which is rich in c9,t11,t13-cln, inhibited the occurrence of colonic aberrant crypt foci (acf) induced by azoxymethane (aom). in this study, we investigated the effect of dietary pgo on the development of aom-induced colonic malignancies and compared it w ... | 2004 | 15182427 |
| effective medicinal plants against enterohaemorrhagic escherichia coli o157:h7. | the stimulating effect of subinhibitory concentrations of antibiotics on the production of verocytotoxin (vt) by enterohaemorrhagic escherichia coli (ehec) o157:h7 has been claimed. the purpose of this study was to find an alternative, but bioactive medicine for the treatment of this organism. fifty-eight preparations of aqueous and ethanolic extracts of 38 medicinal plant species commonly used in thailand to cure gastrointestinal infections were tested for their antibacterial activity against d ... | 2004 | 15261962 |
| study on wound healing activity of punica granatum peel. | the methanolic extract of dried pomegranate (punica granatum) peels showed the presence of a high content of phenolic compounds (44.0%) along with other constituents. this extract was formulated as a 10% (wt/wt) water-soluble gel and was studied for its wound healing property against an excision wound on the skin of wistar rats. the activity was compared with that of a commercial topical antibacterial applicant. the wound healing activity was assessed by measuring the percent contraction in skin ... | 2004 | 15298776 |
| bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (punica granatum l.) juice. | ellagic acid (ea) and hydrolyzable ellagitannins (ets) are dietary polyphenols found in fruits and nuts and implicated with potent antioxidant, anticancer and antiatherosclerotic biological properties. unfortunately, there are no reports on the bioavailability studies of ea or ets in the human body. we conducted in vivo studies whereby a human subject consumed pomegranate juice (pj) (180 ml) containing ea (25 mg) and ets (318 mg, as punicalagins, the major fruit ellagitannin). | 2004 | 15369737 |
| anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates mapk and nf-kappab pathways and inhibits skin tumorigenesis in cd-1 mice. | chemoprevention has come of age as an effective cancer control modality; however, the search for novel agent(s) for the armamentarium of cancer chemoprevention continues. we argue that agents capable of intervening at more than one critical pathway in the carcinogenesis process will have greater advantage over other single-target agents. pomegranate fruit extract (pfe) derived from the tree punica granatum possesses strong antioxidant and antiinflammatory properties. pomegranate fruit was extrac ... | 2005 | 15455341 |
| antimicrobial evaluation of some medicinal plants for their anti-enteric potential against multi-drug resistant salmonella typhi. | screening was done of some plants of importance in the ayurvedic system of traditional medicine used in india to treat enteric diseases. fifty four plant extracts (methanol and aqueous) were assayed for their activity against multi-drug resistant salmonella typhi. strong antibacterial activity was shown by the methanol extracts of aegle marmelos, salmalia malabarica, punica granatum, myristica fragrans, holarrhena antidysenterica, terminalia arjuna and triphal (mixture of emblica of fi cinalis, ... | 2004 | 15476301 |
| antiviral activities of medicinal herbs traditionally used in southern mainland china. | the aqueous extracts from 21 medicinal herbs traditionally used in southern mainland china were screened for antiviral activities against human herpes simplex virus type 1 (hsv-1) and human respiratory syncytial virus (rsv) using a cytopathic effect (cpe) reduction assay. three extracts from agrimonia pilosa, pithecellobium clypearia and punica granatum, respectively, showed anti-hsv-1 activity, which was possibly contributed by the polyphenolic compounds in the herbal extracts. six of the extra ... | 2004 | 15478204 |
| punica granatum (pomegranate) juice provides an hiv-1 entry inhibitor and candidate topical microbicide. | for approximately 24 years the aids pandemic has claimed approximately 30 million lives, causing approximately 14,000 new hiv-1 infections daily worldwide in 2003. about 80% of infections occur by heterosexual transmission. in the absence of vaccines, topical microbicides, expected to block virus transmission, offer hope for controlling the pandemic. antiretroviral chemotherapeutics have decreased aids mortality in industrialized countries, but only minimally in developing countries. to prevent ... | 2004 | 15485580 |
| pomegranate fruit extract modulates uv-b-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa b in normal human epidermal keratinocytes paragraph sign. | excessive exposure of solar ultraviolet (uv) radiation, particularly its uv-b component, to humans causes many adverse effects that include erythema, hyperplasia, hyperpigmentation, immunosuppression, photoaging and skin cancer. in recent years, there is increasing use of botanical agents in skin care products. pomegranate derived from the tree punica granatum contains anthocyanins (such as delphinidin, cyanidin and pelargonidin) and hydrolyzable tannins (such as punicalin, pedunculagin, punical ... | 2005 | 15493960 |
| possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions. | we investigated whether dissimilar biochemical fractions originating in anatomically discrete sections of the pomegranate (punica granatum) fruit might act synergistically against proliferation, metastatic potential, and phosholipase a2 (pla2) expression of human prostate cancer cells in vitro . proliferation of du 145 human prostate cancer cells was measured following treatment with a range of therapeutically active doses of fermented pomegranate juice polyphenols (w) and sub-therapeutic doses ... | 2005 | 15528976 |
| breast cancer chemopreventive properties of pomegranate (punica granatum) fruit extracts in a mouse mammary organ culture. | we previously reported anticancer effects of pomegranate extracts in human breast cancer cells in vitro and also chemopreventive activity of pomegranate fermented juice polyphenols (w) in a mouse mammary organ culture (mmoc). in the present study we decided to expand the mmoc investigations to also include an evaluation of the potential chemopreventive efficacy of a purified chromatographic peak of w (peak b), and also of whole pomegranate seed oil. in brief, an mmoc was established according to ... | 2004 | 15554563 |
| pomegranate extract inhibits staphylococcus aureus growth and subsequent enterotoxin production. | in brazil, pomegranate (punica granatum l. (punicaceae)) is widely used as a phytotherapeutic agent. this study evaluates the effect of pomegranate extract on staphylococcus aureus fri 722 growth and subsequent enterotoxin production. bacterial susceptibility was determined by tube dilution method and production of enterotoxin was assessed using membrane-over-agar (moa) plates. at a low extract concentration (0.01% v/v) bacterial growth was delayed, while a higher concentration (1% v/v) eliminat ... | 2005 | 15588686 |
| bioactive compounds from the seeds of punica granatum (pomegranate). | two new compounds, coniferyl 9-o-[beta-d-apiofuranosyl(1-->6)]-o-beta-d-glucopyranoside (1) and sinapyl 9-o-[beta-d-apiofuranosyl(1-->6)]-o-beta-d-glucopyranoside (2), were isolated from the seeds of punica granatum (pomegranate), together with five known compounds, 3,3'-di-o-methylellagic acid (3), 3,3',4'-tri-o-methylellagic acid (4), phenethyl rutinoside, icariside d1, and daucosterol. the structures of 1 and 2 were elucidated by spectroscopic data analysis. compounds 1-4 exhibited antioxidan ... | 2004 | 15620261 |
| pomegranate (punica granatum) pure chemicals show possible synergistic inhibition of human pc-3 prostate cancer cell invasion across matrigel. | four pure chemicals, ellagic acid (e), caffeic acid (c), luteolin (l) and punicic acid (p), all important components of the aqueous compartments or oily compartment of pomegranate fruit (punica granatum), and each belonging to different representative chemical classes and showing known anticancer activities, were tested as potential inhibitors of in vitro invasion of human pc-3 prostate cancer cells in an assay employing matrigel artificial membranes. all compounds significantly inhibited invasi ... | 2005 | 15744587 |
| flavonoids from punica granatum--potential antiperoxidative agents. | fractions rich in flavonoids obtained from the fruits of punica granatum extract, orally administered to rats at dose of 10 mg kg(-1) day(-1), showed potential antiperoxidative effect. concentrations of malondialdehyde, hydroperoxides and conjugated dienes were significantly decreased in liver while the activities of the enzymes catalase, superoxide dismutase (sod), glutathione peroxidase and glutathione reductase showed significant elevation. concentrations of glutathione in the tissues were al ... | 2005 | 15752628 |
| effect of certain bioactive plant extracts on clinical isolates of beta-lactamase producing methicillin resistant staphylococcus aureus. | ethanolic extracts and some fractions from 10 indian medicinal plants, known for antibacterial activity, were investigated for their ability to inhibit clinical isolates of beta-lactamase producing methicillin-resistant staphylococcus aureus (mrsa) and methicillin-sensitive s. aureus (mssa). synergistic interaction of plant extracts with certain antibiotics was also evaluated. the mrsa test strains were found to be multi-drug resistant and also exhibited high level of resistance to common beta-l ... | 2005 | 15812867 |
| pomegranate flower improves cardiac lipid metabolism in a diabetic rat model: role of lowering circulating lipids. | excess triglyceride (tg) accumulation and increased fatty acid (fa) oxidation in the diabetic heart contribute to cardiac dysfunction. punica granatum flower (pgf) is a traditional antidiabetic medicine. here, we investigated the effects and mechanisms of action of pgf extract on abnormal cardiac lipid metabolism both in vivo and in vitro. long-term oral administration of pgf extract (500 mg kg(-1)) reduced cardiac tg content, accompanied by a decrease in plasma levels of tg and total cholestero ... | 2005 | 15880139 |
| activity of medicinal plant extracts against hospital isolates of methicillin-resistant staphylococcus aureus. | aqueous and ethanolic extracts of ten traditional thai medicinal plants were investigated for their ability to inhibit 35 hospital isolates of methicillin-resistant staphylococcus aureus (mrsa). nine medicinal plants displayed activity against all isolates tested. ethanolic extracts of garcinia mangostana, punica granatum and quercus infectoria were most effective, with mics for mrsa isolates of 0.05-0.4, 0.2-0.4 and 0.2-0.4 mg/ml, respectively, and for s. aureus atcc 25923 of 0.1, 0.2 and 0.1 m ... | 2005 | 15882206 |
| punica granatum flower extract, a potent alpha-glucosidase inhibitor, improves postprandial hyperglycemia in zucker diabetic fatty rats. | postprandial hyperglycemia plays an important role in the development of type 2 diabetes and has been proposed as an independent risk factor for cardiovascular diseases. the flowering part of punica granatum linn. (punicaceae) (pgf) has been recommended in unani literature as a remedy for diabetes. we investigated the effect and action mechanism of a methanolic extract from pgf on hyperglycemia in vivo and in vitro. oral administration of pgf extract markedly lowered plasma glucose levels in non ... | 2005 | 15894133 |
| in vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. | pomegranate (punica granatum l.) fruits are widely consumed as juice (pj). the potent antioxidant and anti-atherosclerotic activities of pj are attributed to its polyphenols including punicalagin, the major fruit ellagitannin, and ellagic acid (ea). punicalagin is the major antioxidant polyphenol ingredient in pj. punicalagin, ea, a standardized total pomegranate tannin (tpt) extract and pj were evaluated for in vitro antiproliferative, apoptotic and antioxidant activities. punicalagin, ea and t ... | 2005 | 15936648 |
| antibacterial properties of some plants used in mexican traditional medicine for the treatment of gastrointestinal disorders. | antibacterial properties of aqueous and methanolic extracts of 26 medicinal plants used in mexico to treat gastrointestinal disorders were tested against eight different species of enteropathogens: two escherichia coli species; two shigella sonnei species; two shigella flexneri species; and two salmonella sp. species. the results showed that all crude extracts exhibited antibacterial activity, at least against one of the microorganisms tested, at concentrations of 8 mg/ml or lower. the extracts ... | 2005 | 16005589 |
| anti-diabetic action of punica granatum flower extract: activation of ppar-gamma and identification of an active component. | peroxisome proliferator-activated receptor (ppar)-gamma activators are widely used in the treatment of type 2 diabetes because they improve the sensitivity of insulin receptors. punica granatum flower (pgf) has been used as an anti-diabetic medicine in unani medicinal literature. the mechanism of actions is, however, unknown. in the current study, we demonstrated that 6-week oral administration of methanol extract from pgf (500 mg/kg, daily) inhibited glucose loading-induced increase of plasma g ... | 2005 | 16102567 |
| punica granatum l. extract inhibits il-1beta-induced expression of matrix metalloproteinases by inhibiting the activation of map kinases and nf-kappab in human chondrocytes in vitro. | interleukin (il)-1beta induces the expression of matrix metalloproteinases (mmps) implicated in cartilage resorption and joint degradation in osteoarthritis (oa). pomegranate fruit extract (pfe) was recently shown to exert anti-inflammatory effects in different disease models. however, no studies have been undertaken to investigate whether pfe constituents protect articular cartilage. in the present studies, oa chondrocytes or cartilage explants were pretreated with pfe and then stimulated with ... | 2005 | 16140882 |
| effect of an herbal formula containing ganoderma lucidum on reduction of herpes zoster pain: a pilot clinical trial. | administration of hot water extracts of a herbal formula containing ganoderma lucidum, wtmcgepp (wisteria floribunda 0.38, trapa natans 0.38, miristica agrans 0.38, coix lachryma-jobi 0.75, cultivated ganoderma lucidum 0.75, elfuinga applanata 0.38, tissue cultured panax ginseng 0.3, and punica granatum 0.38: numerals designate dry weight gram/dose), decreased herpes zoster pain for five japanese patients suffering from shingles. pain relief started within a few days of intake and was almost com ... | 2005 | 16173526 |
| synergic interaction between pomegranate extract and antibiotics against staphylococcus aureus. | we evaluated the interaction between punica granatum (pomegranate) methanolic extract (pgme) and antibiotics against 30 clinical isolates of methicillin-resistant staphylococcus aureus (mrsa) and methicillin-sensitive staphylococcus aureus (mssa). susceptibility testing of the isolates to pgme and antibiotics was performed by the broth dilution method. synergic activity was detected between pgme and the 5 antibiotics tested, chloramphenicol, gentamicin, ampicillin, tetracycline, and oxacillin, r ... | 2005 | 16175202 |
| pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. | prostate cancer is the most common invasive malignancy and the second leading cause of cancer-related deaths among u.s. males, with a similar trend in many western countries. one approach to control this malignancy is its prevention through the use of agents present in diet consumed by humans. pomegranate from the tree punica granatum possesses strong antioxidant and antiinflammatory properties. we recently showed that pomegranate fruit extract (pfe) possesses remarkable antitumor-promoting effe ... | 2005 | 16192356 |
| pomegranate as a cosmeceutical source: pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells. | pomegranate (punica granatum) is an ancient fruit with exceptionally rich ethnomedical applications. the peel (pericarp) is well regarded for its astringent properties; the seeds for conferring invulnerability in combat and stimulating beauty and fertility. here, aqueous fractions prepared from the fruit's peel and fermented juice and lipophilic fractions prepared from pomegranate seeds were examined for effects on human epidermal keratinocyte and human dermal fibroblast function. pomegranate se ... | 2006 | 16221534 |
| pomegranate flower extract diminishes cardiac fibrosis in zucker diabetic fatty rats: modulation of cardiac endothelin-1 and nuclear factor-kappab pathways. | the diabetic heart shows increased fibrosis, which impairs cardiac function. endothelin (et)-1 and nuclear factor-kappab (nf-kappab) interactively regulate fibroblast growth. we have recently demonstrated that punica granatum flower (pgf), a unani anti-diabetic medicine, is a dual activator of peroxisome proliferator-activated receptor (ppar)-alpha and -gamma, and improves hyperglycemia, hyperlipidemia, and fatty heart in zucker diabetic fatty (zdf) rat, a genetic animal model of type 2 diabetes ... | 2005 | 16306813 |
| cyp3a4 and cyp2d6 inhibitory activities of indonesian medicinal plants. | thirty samples of indonesian medicinal plants were analyzed for their capacity to inhibit in vitro metabolism by human cytochrome p450 3a4 (cyp3a4) and cyp2d6 with a radiometric assay. the meoh-soluble fractions of 25 samples, prepared from water extracts, demonstrated inhibitory activity more than 50% on the metabolism mediated by cyp3a4, and 21 samples on the metabolism mediated by cyp2d6. among the meoh-soluble fractions, piper nigrum leaf showed the highest inhibitory activity against cyp3a4 ... | 2006 | 16360935 |
| punica granatum (pomegranate) juice provides an hiv-1 entry inhibitor and candidate topical microbicide. | for approximately 24 years the aids pandemic has claimed approximately 30 million lives, causing approximately 14,000 new hiv-1 infections daily worldwide in 2003. about 80% of infections occur by heterosexual transmission. in the absence of vaccines, topical microbicides, expected to block virus transmission, offer hope for controlling the pandemic. antiretroviral chemotherapeutics have decreased aids mortality in industrialized countries, but only minimally in developing countries. to prevent ... | 2005 | 16387698 |
| beta-secretase (bace1) inhibitors from pomegranate (punica granatum) husk. | in the course of screening for anti-dementia agents from natural products, two beta-secretase (bace1) inhibitors were isolated from the husk of pomegranate (punica granatum) by activity-guided purification. they were identified as ellagic acid and punicalagin with ic50 values of 3.9 x10(-6) and 4.1x10(-7) m and ki values of 2.4x10(-5) and 5.9x10(-7) m, respectively. the compounds were non-competitive inhibitors with a substrate in the dixon plot. ellagic acid and punicalagin were less inhibitory ... | 2005 | 16392663 |
| punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates fe-nta induced hepatotoxicity in mice. | most pomegranate (punica granatum linn., punicaceae) fruit parts are known to possess enormous antioxidant activity. the present study evaluated antioxidant and hepatoprotective activity of pomegranate flowers. alcoholic (ethanolic) extract of flowers was prepared and used in the present study. the extract was found to contain a large amount of polyphenols and exhibit enormous reducing ability, both indicative of potent antioxidant ability. the extract showed 81.6% antioxidant activity in dpph m ... | 2006 | 16426722 |
| pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. | phytochemicals from fruits such as the pomegranate (punica granatum l) may inhibit cancer cell proliferation and apoptosis through the modulation of cellular transcription factors and signaling proteins. in previous studies, pomegranate juice (pj) and its ellagitannins inhibited proliferation and induced apoptosis in ht-29 colon cancer cells. the present study examined the effects of pj on inflammatory cell signaling proteins in the ht-29 human colon cancer cell line. at a concentration of 50 mg ... | 2006 | 16448212 |
| prostate cancer prevention through pomegranate fruit. | prostate cancer (cap) is the second leading cause of cancer-related deaths among u.s. males with a similar trend in many western countries. cap is an ideal candidate disease for chemoprevention because it is typically diagnosed in men over 50 years of age, and thus even a modest delay in disease progression achieved through pharmacological or nutritional intervention could significantly impact the quality of life of these patients. in this regard we and others have proposed the use of dietary an ... | 2006 | 16479165 |
| antibacterial properties of tropical plants from puerto rico. | in an effort to document the antibacterial properties of plants commonly used by the people of puerto rico, we studied the effects of 172 plant species, utilizing the disc diffusion method, against escherichia coli and staphylococcus aureus. the methanolic extracts of 14 species showed antibacterial activities during this preliminary screen. these positive plant extracts were tested successively over 15 additional species. the results showed that extracts from citrus aurantifolia (rutaceae), cit ... | 2006 | 16492531 |
| antibacterial activities of medicinal plants used for the treatment of diarrhoea in limpopo province, south africa. | the ethnobotanical survey conducted in this study showed that 21 plant species belonging to 14 families are used in traditional medical practice in limpopo province, south africa, for the treatment of diarrhoea. methanol, ethanol, acetone and hot water extract from different plant parts (leaves, roots, bark and stem rhizome), of several of these plants (indigofera daleoides, punica granatum, syzygium cordatum, gymnosporia senegalensis, ozoroa insignis, elephantorrhiza elephantina, elephantorrhiz ... | 2006 | 16545928 |
| in vitro susceptibility of entamoeba histolytica and giardia lamblia to plants used in mexican traditional medicine for the treatment of gastrointestinal disorders. | in our search for new antiprotozoal chemotherapy, we collected a selection of 26 plants used in mexican traditional medicine for the treatment of gastrointestinal disorders. methanolic extracts of these species were screened for their antiprotozoal activity against entamoeba histolytica and giardia lamblia trophozoites using in vitro tests. among the tested extracts, the derivates of following species showed selectivity and significant antiprotozoal activity: chiranthodendron pentadactylon, anno ... | 2006 | 16846708 |
| constituents of the flowers of punica granatum. | a new polyphenol compound named pomegranatate (1), together with, ellagic acid, 3,3',4'-tri-o-methylellagic acid, ethyl brevifolincarboxylate, urolic and maslinic acids, and daucosterol were isolated from the ethanolic extract of the flowers of punica granatum. the structure of compound 1 was determined by spectroscopic analysis. maslinic acid exhibited antioxidant activity, evaluated by measurement of ldl susceptibility to oxidation. | 2006 | 16887296 |
| inhibition of aflatoxin b production of aspergillus flavus, isolated from soybean seeds by certain natural plant products. | the inhibitory effect of cowdung fumes, captan, leaf powder of withania somnifera, hyptis suaveolens, eucalyptus citriodora, peel powder of citrus sinensis, citrus medica and punica granatum, neem cake and pongamia cake and spore suspension of trichoderma harzianum and aspergillus niger on aflatoxin b(1) production by toxigenic strain of aspergillus flavus isolated from soybean seeds was investigated. | 2006 | 17032218 |
| antimicrobial activity of some ethnomedicinal plants used by paliyar tribe from tamil nadu, india. | antimicrobial activity of 18 ethnomedicinal plant extracts were evaluated against nine bacterial strains (bacillus subtilis, staphylococcus aureus, staphylococcus epidermidis, enterococcus faecalis, escherichia coli, klebsiella pneumonia, pseudomonas aeruginosa, ervinia sp, proteus vulgaris) and one fungal strain (candida albicans). the collected ethnomedicinal plants were used in folk medicine in the treatment of skin diseases, venereal diseases, respiratory problems and nervous disorders. | 2006 | 17042964 |
| medicinal plant extracts as anti-escherichia coli o157:h7 agents and their effects on bacterial cell aggregation. | ethanolic extracts of eight thai medicinal plants (representing five families) that are used as traditional remedies for treating diarrhea were examined with a salt aggregation test for their ability to modulate cell surface hydrophobicity of enterohemorrhagic escherichia coli strains, including e. coli o157:h7. four of these medicinal plants, acacia catechu, peltophorum pterocarpum, punica granatum, and quercus infectoria, have high bacteriostatic and bactericidal activities. the ethanolic extr ... | 2006 | 17066910 |
| absorption, metabolism, and antioxidant effects of pomegranate (punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers. | the intake of polyphenols has been demonstrated to have health-promoting and disease-preventive effects. the pomegranate (punica granatum l.), which is rich in several polyphenols, has been used for centuries in ancient cultures for its medicinal purposes. the potential health benefits of pomegranate polyphenols have been demonstrated in numerous in vitro studies and in vivo experiments. this study investigated the absorption and antioxidant effects of a standardized extract from pomegranate in ... | 2006 | 17090147 |
| minimum inhibitory concentration of adherence of punica granatum linn (pomegranate) gel against s. mutans, s. mitis and c. albicans. | the purpose of this study was to investigate the antimicrobial effect of a punica granatum linn (pomegranate) phytotherapeutic gel and miconazole (daktarin oral gel) against three standard streptococci strains (mutans atcc 25175, sanguis atcc 10577 and mitis atcc 9811), s. mutans clinically isolated and candida albicans either alone or in association. the effect of minimum inhibitory concentrations of the gels on the adherence of these microorganisms to glass was assessed in the presence of 5% s ... | 2006 | 17262129 |
| cytoprotective effect of preparations from various parts of punica granatum l. fruits in oxidatively injured mammalian cells in comparison with their antioxidant capacity in cell free systems. | pomegranate (punica granatum l.) juice (pj) is being increasingly proposed as a nutritional supplement to prevent atherosclerosis in humans. this therapeutically valuable potential has been attributed to pj antioxidant capacity which has been mostly tested by means of cell-free assays: indeed, to the best of our knowledge, no study has focused on the direct antioxidant capacity of pj in cultured cells. here, the antioxidant capacity in cell free-systems of preparations from various parts of pome ... | 2007 | 17376699 |
| antibacterial properties of traditionally used indian medicinal plants. | in search of broad-spectrum antibacterial activity from traditionally used indian medicinal plants, 66 ethanolic plant extracts were screened against nine different bacteria. of these, 39 extracts demonstrated activity against six or more test bacteria. twelve extracts showing broad-spectrum activity were tested against specific multidrug-resistant (mdr) bacteria, methicillin-resistant staphylococcus aureus (mrsa) and extended spectrum beta-lactamases (esbetal)-producing enteric bacteria. in vit ... | 2007 | 17440624 |
| agrobacterium-mediated transformation of the dwarf pomegranate (punica granatum l. var. nana). | the dwarf pomegranate (punica granatum l. var. nana) is a dwarf ornamental plant that has the potential to be the model plant of perennial fruit trees because it bears fruits within 1 year of seedling. we established an agrobacterium-mediated transformation system for the dwarf pomegranate. adventitious shoots regenerated from leaf segments were inoculated with a. tumefaciens strain eha105 harboring the binary vector pbin19-sgfp, which contains neomycin phosphotransferase (npt ii) and green fluo ... | 2007 | 17453216 |
| effect of pomegranate (punica granatum) juice intake on hepatic oxidative stress. | pomegranate juice (pj) possesses a high antioxidant activity, which has been related to beneficial health properties. however, in vivo confirmation and characterization of these effects on biological systems are lacking and needed. this study was performed in order to investigate the effect of prolonged pj ingestion on general oxidation status. for this purpose, mice ingested pj (or water in control group) during four weeks, after which damage to lipids, proteins and dna were evaluated as oxidat ... | 2007 | 17514376 |
| antioxidant, antimalarial and antimicrobial activities of tannin-rich fractions, ellagitannins and phenolic acids from punica granatum l. | the punica granatum l. (pomegranate) by-product pomx was partitioned between water, etoac and n-buoh, and the etoac and n-buoh extracts were purified by xad-16 and sephadex lh-20 column chromatography to afford ellagic acid (1), gallagic acid (2), punicalins (3), and punicalagins (4). compounds 1 - 4 and the mixture of tannin fractions (xad-16 eluates) were evaluated for antioxidant, antiplasmodial, and antimicrobial activities in cell-based assays. the mixture of tannins (tpt), xad-etoac, xad-h ... | 2007 | 17566148 |
| inhibition of uvb-mediated oxidative stress and markers of photoaging in immortalized hacat keratinocytes by pomegranate polyphenol extract pomx. | in recent years there has been an increase in use of botanicals with antioxidant properties as skin photoprotective agents. pomegranate (punica granatum l.) fruit possesses strong antioxidant and antiinflammatory properties. recently, we have shown that pomegranate-derived products rich in anthocyanidins and ellagitannins inhibit uvb-mediated activation of nuclear factor kappa b and modulate uva-mediated cell proliferation pathways in normal human epidermal keratinocytes. in this study, we evalu ... | 2007 | 17645659 |
| elemental and nutritional analysis of punica granatum from turkey. | twenty different varieties of pomegranate (punica granatum) from turkey were analyzed for vitamin c level, lipid content, sterol determination, anthocyanin content, and elemental analysis (ca, mg, p, fe, na, and k studies). vitamin c content range of 1,050-312 mg/100 g, oil content range of 2.41-3.73%, sterol content range of 5.78-8.43%, anthocyanin content range of 2,100-4,400 mg/l, potassium range of 250-1,200 ppm, calcium range of 35-326 ppm, magnesium range of 176-427 ppm, iron range of 21-4 ... | 2007 | 17651082 |
| pomegranate peel extract prevents liver fibrosis in biliary-obstructed rats. | punica granatum l. (pomegranate) is a widely used plant that has high nutritional value. the aim of this study was to assess the effect of chronic administration of pomegranate peel extract (ppe) on liver fibrosis induced by bile duct ligation (bdl) in rats. ppe (50 mg kg(-1)) or saline was administered orally for 28 days. serum aspartate aminotransferase (ast), alanine aminotransferase (alt) and lactate dehydrogenase (ldh) levels were determined to assess liver function and tissue damage. proin ... | 2007 | 17939210 |
| antibacterial activity directed isolation of compounds from punica granatum. | chemical investigation of the methanolic extract of pomegranate fruit following antibacterial activity directed isolation led to the isolation of pelargonidin-3-galactose, cyanidin-3-glucose, gallic acid, quercetin, and myricetin. all these compounds exhibited substantial activity against species of corynebacteria, staphylococci, streptococci, bacillus subtilis, shigella, salmonella, vibrio cholera, and escherichia coli. however, all these compounds were more active against gram-positive species ... | 2007 | 18034726 |
| assessment of the genotoxic risk of punica granatum l. (punicaceae) whole fruit extracts. | punica granatum l. (punicaceae) whole fruit extracts, have been used in cuban traditional medicine as an effective drug for the treatment of respiratory diseases. this species showed interesting anti-viral activity, e.g. aqueous or hydroalcoholic extracts of whole fruits have proved highly active against the influenza virus. however, some toxic properties of this extract have also been reported and, to date, very little is known about its genotoxic properties. in the present study, the genotoxic ... | 2008 | 18036756 |
| isolation and identification of two lipid transfer proteins in pomegranate (punica granatum). | lipid transfer proteins (ltps) are a family of low molecular mass (7-9 kda) polypeptides, the members of which share 35-95% sequence homology. these proteins are widely distributed throughout the plant kingdom and are receiving attention for their biochemical characteristics and biological activity. ltps are indeed studied in different research fields varying from allergy to food technology, and numerous molecules belonging to this class are progressively being identified and investigated. prote ... | 2007 | 18038997 |
| berry fruits: compositional elements, biochemical activities, and the impact of their intake on human health, performance, and disease. | an overwhelming body of research has now firmly established that the dietary intake of berry fruits has a positive and profound impact on human health, performance, and disease. berry fruits, which are commercially cultivated and commonly consumed in fresh and processed forms in north america, include blackberry ( rubus spp.), black raspberry ( rubus occidentalis), blueberry ( vaccinium corymbosum), cranberry (i.e., the american cranberry, vaccinium macrocarpon, distinct from the european cranbe ... | 2008 | 18211023 |
| a new species of fomitiporia (hymenochaetaceae, basidiomycota) from china based on morphological and molecular characters. | fomitiporia punicata sp. nov., collected from shaanxi province, northern china, and so far exclusively on punica granatum (punicaceae), is described and illustrated, and its preliminary phylogenetic relationships are inferred based on sequence data from the ribosomal its-5.8s regions. fomitiporia punicata belongs to the f. robusta-f. punctata complex, but is characterized by an effused-reflexed to pileate basidioma with triquetrous to ungulate pilei, pale yellowish brown to cinnamon brown pore s ... | 2008 | 18308524 |
| ecology of aphidophagous predators in pomegranate ecosystem in india. | the aphid, aphis punicae passerini (homoptera : aphididae) is a serious pest attacking pomegranate (punica granatum l.), an important semi arid fruit crop grown widely in most parts of the country. the major predators found preying on a. punicae in pomegranate ecosystem were cheilomenes sexmaculata (fabricius), scymnus sp., pseudaspidemerus circumflexo (motsch.), paragus serratus (fabricius), ischiodon scutellaris (fabricius) and chrysopa sp. the population dynamics and spatial distribution of t ... | 2007 | 18399481 |
| antibacterial activity of some medicinal plant extracts. | antibacterial activity of hot aqueous and methanolic extracts prepared from six plants (terminallia chebula, terminallia bellerica, phyllanthus emblica, punica granatum, lawsonia alba and mikania micrantha) used in traditional folk medicines of india were screened against five pathogenic bacteria (staphylococcus aureus mtcc 2940, bacillus subtilis mtcc 441, escherichia coli mtcc 739, proteus vulgaris mtcc 426 and enterobacter aerogenes mtcc 111). the highest antibacterial potentiality was exhibi ... | 2008 | 18404337 |
| preparation and characterization of herbal creams for improvement of skin viscoelastic properties. | the aim of this study was to formulate and evaluate herbal cosmetic creams for their improvement of skin viscoelastic and hydration properties. the cosmetic cream formulations were designed by using ethanolic extracts of glycyrriza glabra, curcuma longa (roots), seeds of psorolea corlifolia, cassia tora, areca catechu, punica granatum, fruits of embelica officinale, leaves of centella asiatica, dried bark of cinnamon zeylanicum and fresh gel of aloe vera in varied concentrations (0.12-0.9%w/w) a ... | 2008 | 18452435 |
| immune-suppressive activity of punicalagin via inhibition of nfat activation. | since t cell activation is central to the development of autoimmune diseases, we screened a natural product library comprising 1400 samples of medicinal herbal extracts, to identify compounds that suppress t cell activity. punicalagin (pcg) isolated from the fruit of punica granatum was identified as a potent immune suppressant, based on its inhibitory action on the activation of the nuclear factor of activated t cells (nfat). pcg downregulated the mrna and soluble protein expression of interleu ... | 2008 | 18466764 |
| traditional medicinal plants of cold desert ladakh-used against kidney and urinary disorders. | traditional medicine of clod desert ladakh has large potential to treat various ailments among tribal communities inhabited in the remotest region of indian subcontinent. this study was conducted to document the new ethno-medico-botanical information and traditional use of medicinal plants against kidney and urinary disorders, and thus to conserve the rapidly disappearing traditional knowledge system of amchis of ladakh. | 2008 | 18550306 |
| bioavailable constituents/metabolites of pomegranate (punica granatum l) preferentially inhibit cox2 activity ex vivo and il-1beta-induced pge2 production in human chondrocytes in vitro. | abstract: several recent studies have documented that supplementation with pomegranate fruit extract inhibits inflammatory symptoms in vivo. however, the molecular basis of the observed effects has not been fully revealed. although previous studies have documented the inhibition of nitric oxide and cyclooxygenase (cox) activity in vitro by plant and fruit extracts added directly into the culture medium but whether concentrations of bioactive compounds sufficient enough to exert such inhibitory e ... | 2008 | 18554383 |
| safety assessment of pomegranate fruit extract: acute and subchronic toxicity studies. | pomegranate (punica granatum l.) fruit is widely consumed as fresh fruit and juice. because of its potential for health benefits, pomegranate fruit extracts have been commonly marketed as dietary supplements in recent years. the objective of the present study was to investigate potential adverse effects, if any, of a standardized pomegranate fruit extract in rats following subchronic administration. the extract was standardized to 30% punicalagins, the active anomeric ellagitannins responsible f ... | 2008 | 18571823 |
| therapeutic applications of pomegranate (punica granatum l.): a review. | the pomegranate, punica granatum l., is an ancient, mystical, unique fruit borne on a small, long-living tree cultivated throughout the mediterranean region, as far north as the himalayas, in southeast asia, and in california and arizona in the united states. in addition to its ancient historical uses, pomegranate is used in several systems of medicine for a variety of ailments. the synergistic action of the pomegranate constituents appears to be superior to that of single constituents. in the p ... | 2008 | 18590349 |
| medicinal values of fruit peels from citrus sinensis, punica granatum, and musa paradisiaca with respect to alterations in tissue lipid peroxidation and serum concentration of glucose, insulin, and thyroid hormones. | peel extracts from citrus sinensis, punica granatum, and musa paradisiaca were investigated for their effects on tissue lipid peroxidation (lpo) and on the concentration of thyroid hormones, insulin, and glucose in male rats. in vitro inhibition of h(2)o(2)-induced lpo in red blood cells of rats by 0.25, 0.50, 1.0, and 2.0 microg/ml c. sinensis, p. granatum, and m. paradisiaca peel extracts was observed in a dose-specific manner. maximum inhibition was observed at 0.50 microg/ml c. sinensis, 2.0 ... | 2008 | 18598183 |
| protective effects of standardized pomegranate (punica granatum l.) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts. | exposure to ultraviolet (uv) radiation has been associated with several acute and chronic conditions, including sunburn, edema, hyperplasia, immunosuppression, photoaging, and skin cancer. the role of naturally occurring phytochemicals in the prevention of such uv-related conditions has captured increased interest. pomegranate ( punica granatum l.) is a rich source of polyphenolics, which have been shown to exert anti-inflammatory, antioxidant, and anticarcinogenic activity in numerous in vivo a ... | 2008 | 18717570 |
| antidiabetic potential of citrus sinensis and punica granatum peel extracts in alloxan treated male mice. | an investigation on the effects of four different concentrations of peel extract from citrus sinensis (cs) or punica granatum (pg) in male mice revealed the maximum glucose lowering and antiperoxidative activities at 25 mg/kg of cs and 200 mg/kg of pg. in a separate experiment their potential was evaluated with respect to the regulation of alloxan induced diabetes mellitus. while a single dose of alloxan (120 mg/kg) increased the serum levels of glucose and alpha-amylase activity, rate of water ... | 2007 | 18806305 |
| antioxidant activity of some jordanian medicinal plants used traditionally for treatment of diabetes. | medicinal plants are being used extensively in jordanian traditional medicinal system for the treatment of diabetes symptoms. twenty one plant samples were collected from different jordanian locations and used for antioxidant evaluation. the level of antioxidant activity was determined by dpph and abts assays in relation to the total phenolic contents of the medically used parts. the most frequently used plant parts as medicines were fruit, shoot and leaves. the total phenolic contents of methan ... | 2008 | 18817155 |
| screening of nepalese crude drugs traditionally used to treat hyperpigmentation: in vitro tyrosinase inhibition. | south-east asian population is daily exposed to strong sunlight. as a result, the majority of population will have darker, ethnic skin. moreover, many people suffer from dark spots, hyperpigmentation, which is considered to be a skin disorder and causes psychological disturbance. to treat dark spots, most of the population will still rely on traditionally used crude drugs, knowledge about which is transferred from generation to generation. fifty-two crude drugs were selected based on the survey ... | 2008 | 18822041 |