| a preliminary study of the sedative effects of annona muricata (sour sop). | | 1979 | 473760 |
| structures of the galactomannans from seeds of annona muricata, arenga saccharifera, cocos nucifera, convolvulus tricolor, and sophora japonica. | | 1971 | 4339945 |
| additional bioactive acetogenins, annomutacin and (2,4-trans and cis)-10r-annonacin-a-ones, from the leaves of annona muricata. | in a continuation of our research on bioactive components from the leaves of annona muricata, three novel monotetrahydrofuran annonaceous acetogenins, namely, annomutacin [1], (2,4-trans)-10r-annonacin-a-one [2], and (2,4-cis)-10r- annonacin-a-one [3], have been identified. their structures were deduced by ms, nmr, ir, and uv spectral and chemical methods, and the absolute configurations were determined by mosher ester methodology. a known bioactive amide, n-p-coumaroyl tyramine, was also found. ... | 1995 | 7494150 |
| muricatocins a and b, two new bioactive monotetrahydrofuran annonaceous acetogenins from the leaves of annona muricata. | the leaves of annona muricata have yielded the novel monotetrahydrofuran annonaceous acetogenins, muricatocins a [1] and b [2]. each compound possesses five hydroxyl groups, with two hydroxyl groups at the c-10 and c-12 positions. the absolute configurations of 1 and 2 (except for positions c-10 and c-12) were determined by mosher ester methodology. the c-10, c-12 acetonides (1c, 2c) suggested relative stereochemistry and significantly enhanced cytotoxicity against the a-549 human lung tumor cel ... | 1995 | 7673935 |
| new bioactive monotetrahydrofuran annonaceous acetogenins, annomuricin c and muricatocin c, from the leaves of annona muricata. | the leaves of annona muricata have yielded two additional monotetrahydrofuran annonaceous acetogenins, annomuricin c [1] and muricatocin c [2]. compounds 1 and 2 each possess five hydroxyl groups; two hydroxyl groups are at the c-10/c-11 and c-10/c-12 positions in 1 and 2, respectively. the absolute configurations of 1 and 2, except for positions c-10 and c-11 or c-12, were determined by mosher ester methodology. the c-10/c-11 and c-10/c-12 acetonides (1c, 2c) suggested relative stereochemistry ... | 1995 | 7673936 |
| five novel mono-tetrahydrofuran ring acetogenins from the seeds of annona muricata. | bioactivity-directed fractionation of the seeds of annona muricata l. (annonaceae) resulted in the isolation of five new compounds: cis-annonacin (1), cis-annonacin-10-one (2), cis-goniothalamicin (3), arianacin (4), and javoricin (5). three of these (1-3) are among the first cis mono-tetrahydrofuran ring acetogenins to be reported. nmr analyses of published model synthetic compounds, prepared cyclized formal acetals, and prepared mosher ester derivatives permitted the determinations of absolute ... | 1996 | 8991944 |
| isoquinoline derivatives isolated from the fruit of annona muricata as 5-htergic 5-ht1a receptor agonists in rats: unexploited antidepressive (lead) products. | the fruit and the leaves of annona muricata (annonaceae) are used in traditional medicine for their tranquillizing and sedative properties. extracts of the plant have been shown to inhibit binding of [3h]rauwolscine to 5-htergic 5-ht1a receptors in calf hippocampus, and three alkaloids, annonaine (1), nornuciferine (2) and asimilobine (3), isolated from the fruit have been shown to have ic50 values of 3 microm, 9 microm and 5 microm, respectively, although in ligand-binding studies it was not po ... | 1997 | 9401954 |
| two new mono-tetrahydrofuran ring acetogenins, annomuricin e and muricapentocin, from the leaves of annona muricata. | bioactivity-directed fractionation of the leaf extract of annona muricata l. (annonaceae) has resulted in the isolation of two new annonaceous acetogenins, annomuricine (1) and muricapentocin (2). compounds 1 and 2 are monotetrahydrofuran ring acetogenins bearing two flanking hydroxyl groups; however, each has three additional hydroxyl groups. compound 1 has an erythro 1,2-diol, and 2 has a 1,5,9-triol moiety. both 1 and 2 showed significant cytotoxicities against six types of human tumors, with ... | 1998 | 9584396 |
| dimorphic fungi isolated from spontaneously fermented juice of soursop, annona muricata l. | two new fungi isolated from fermenting juice of soursop annona muricata l., exhibited dimorphism. aerobic hyphae were coenocytic bearing sporangia while vegetative filaments were septate. growth in broth was in discrete units. glucose--yeast extract-peptone broth inoculated with sporangiospores of strain c12 induced arthroconidiospores but it was yeast cells, yeastlike cells, pseudohyphae and pseudomycelia bearing blastospores when strain c13 was inoculated. on the other hand, soursop extract in ... | 1996 | 9676040 |
| modelling sporangiospore-yeast transformation of dimorphomyces strain. | two types of buffered media, strictly defined-ammonium sulphate-basal salts and complex peptone-basal salts, were used for the cultivation of dimorphomyces pleomorphis, one of two dimorphic fungi isolated from fermenting juice of soursop fruit, annona muricata l. the growth count was taken every twenty-four hours. transient morphologies were observed to change from sporangiospores through enlarged globose cells, to granular particles and eventually, polar budding yeast cells in the strictly defi ... | 1996 | 9676041 |
| effect of the extract of annona muricata and petunia nyctaginiflora on herpes simplex virus. | annona muricata (annonaceae) and petunia nyctaginiflora (solanaceae) were screened for their activity against herpes simplex virus-1 (hsv-1) and clinical isolate (obtained from the human keratitis lesion). we have looked at the ability of extract(s) to inhibit the cytopathic effect of hsv-1 on vero cells as indicative of anti-hsv-1 potential. the minimum inhibitory concentration of ethanolic extract of a. muricata and aqueous extract of p. nyctaginiflora was found to be 1 mg/ml. | 1998 | 9687085 |
| muricoreacin and murihexocin c, mono-tetrahydrofuran acetogenins, from the leaves of annona muricata. | bioactivity-directed fractionation of the leaves of annona muricata l. (annonaceae) resulted in the isolation of two new annonaceous acetogenins, muricoreacin (1) and murihexocin c (2). compounds 1 and 2 showed significant cytotoxicities among six human tumor cell lines with selectivities to the prostate adenocarcinoma (pc-3) and pancreatic carcinoma (paca-2) cell lines. | 1998 | 9747542 |
| tropical myeloneuropathies revisited. | an interesting neurological syndrome, characterized by recurrent optic neuritis, cervical myelopathy from syringomyelia, paraparesis, amenorrhea-galactorrhea, and other endocrine problems, has been described among young black women in the french west indies. the etiology remains unknown, but possible links with devic's disease, acute disseminated encephalomyelitis, and neurotoxicity from quinolines in annona muricata teas have been postulated. the largest epidemic of neuropathy in this century o ... | 1998 | 9848004 |
| auxotrophic requirement for sporangiospore--yeast transformation of dimorphomyces diastaticus strain c 12. | the filamentous microorganism tentatively known as dimorphomyces diastaticus originally isolated from fermenting soursop extract, in contradistinction grew in the considiogeneous form in glucose-ammonium sulphate-basal salts buffered medium which induced polar budding yeast cells of another dimorphic microorganism, d. pleomorphis (1). further experiments using this medium showed that a number of growth factors including inositol, thymine and uracil separately incorporated inducted yeast morpholo ... | 1997 | 10386012 |
| possible relation of atypical parkinsonism in the french west indies with consumption of tropical plants: a case-control study. caribbean parkinsonism study group. | in europe and north america, parkinson's disease is the major form of parkinsonism; less than 4% of cases are progressive supranuclear palsy (psp) and about 20% are atypical parkinsonism. the distribution of these subgroups is different in the french west indies. we aimed to define the clinical and demographic specificity of these disorders in guadeloupe and to investigate a postulated link with consumption of herbal tea and fruits from the annonaceae family (annona muricata and annona squamosa) ... | 1999 | 10440304 |
| antitumor and antiviral activity of colombian medicinal plant extracts. | extracts of nine species of plants traditionally used in colombia for the treatment of a variety of diseases were tested in vitro for their potential antitumor (cytotoxicity) and antiherpetic activity. mtt (tetrazolium blue) and neutral red colorimetric assays were used to evaluate the reduction of viability of cell cultures in presence and absence of the extracts. mtt was also used to evaluate the effects of the extracts on the lytic activity of herpes simplex virus type 2 (hsv-2). the 50% cyto ... | 1999 | 10446015 |
| the molluscicidal activity of plants used in brazilian folk medicine. | in a continuing search for new compounds for the control of the vectors of schistosomiasis, we have tested the activity of some brazilian medicinal plants as sources of molluscicidal natural compounds, using two molluscicidal bioassays. twenty-seven crude extracts, from twenty-six species belonging to nineteen families, were tested. seven extracts showed significant molluscicidal activity against biomphalaria glabrata adults with dl50 values of less than 50 ppm, and five of them were very active ... | 2000 | 10715846 |
| cytotoxicity and antileishmanial activity of annona muricata pericarp. | hexane, ethyl acetate and methanol extracts of annona muricata pericarp were tested in vitro against leishmania braziliensis and l. panamensis promastigotes, and against cell line u-937. the ethyl acetate extract was more active than the other extracts and even of glucantime used as reference substance. its fractionation led to the isolation of three acetogenins--annonacin, annonacin a and annomuricin a. | 2000 | 10727816 |
| molluscicidal properties of some species of annona. | in search for plant molluscicides for the vector control of schistosomiasis, ethanolic extracts from different parts of six species of the annonaceae family were evaluated against adult forms and egg masses of biomphalaria glabrata. results from accurate experiments indicate that the majority of analyzed extracts possess properties lethal to biomphalaria glabrata, some of them with significant ld90 values (< 20 ppm), as showed for annona crassiflora m: [pulp and seed (ld50 = 13.21), steem (2.34) ... | 2001 | 11315753 |
| novel cytotoxic annonaceous acetogenins from annona muricata. | seven new annonaceous acetogenins, muricins a-g (1-7), as well as five known compounds, a mixture of muricatetrocin a (8) and muricatetrocin b (9), longifolicin (10), corossolin (11), and corossolone (12), were isolated from the seeds of annona muricata. the structures of all isolates were elucidated and characterized by spectral and chemical methods. these acetogenins showed significantly selective in vitro cytotoxicities toward the human hepatoma cell lines hep g(2) and 2,2,15. | 2001 | 11473425 |
| toxicity of annonaceae for dopaminergic neurons: potential role in atypical parkinsonism in guadeloupe. | in the french west indies there is an abnormally high frequency of levodopa-resistant parkinsonism, suggested to be caused by consumption of fruit and infusions of tropical plants, especially annona muricata (corossol, soursop). to determine whether toxic substances from this plant can cause the neuronal degeneration or dysfunction underlying the syndrome, we exposed mesencephalic dopaminergic neurons in culture to the total extract (totum) of alkaloids from annona muricata root bark and to two ... | 2002 | 11835443 |
| new cytotoxic monotetrahydrofuran annonaceous acetogenins from annona muricata. | three new monotetrahydrofuran annonaceous acetogenins, muricin h (1), muricin i (2), and cis-annomontacin (3), along with five known acetogenins, annonacin, annonacinone, annomontacin, murisolin, and xylomaticin, were isolated from the seeds of annona muricata. additionally, two new monotetrahydrofuran annonaceous acetogenins, cis-corossolone (4) and annocatalin (5), together with four known ones, annonacin, annonacinone, solamin, and corossolone, were isolated from the leaves of this species. t ... | 2002 | 11975482 |
| new adjacent bis-tetrahydrofuran annonaceous acetogenins from annona muricata. | bioactivity-guided fractionation led to the isolation of two new annonaceous acetogenins, annocatacin a ( 1). and annocatacin b ( 2). from the seeds and the leaves, respectively, of annona muricata. compounds 1 and 2 are the first examples where the adjacent bis-tetrahydrofuran ring system is located at c-15. the new structures were elucidated and characterized by spectral and chemical methods. both annonaceous acetogenins 1 and 2 showed significant in vitro cytotoxicity toward the human hepatom ... | 2003 | 12677528 |
| the mitochondrial complex i inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism. | the death of dopaminergic neurons induced by systemic administration of mitochondrial respiratory chain complex i inhibitors such as 1-methyl-4-phenylpyridinium (mpp(+); given as the prodrug 1-methyl-1,2,3,6-tetrahydropyridine) or the pesticide rotenone have raised the question as to whether this family of compounds are the cause of some forms of parkinsonism. we have examined the neurotoxic potential of another complex i inhibitor, annonacin, the major acetogenin of annona muricata (soursop), a ... | 2003 | 14521988 |
| annonacin, a lipophilic inhibitor of mitochondrial complex i, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in guadeloupe. | in guadeloupe, epidemiological data have linked atypical parkinsonism with fruit and herbal teas from plants of the annonaceae family, particularly annona muricata. these plants contain a class of powerful, lipophilic complex i inhibitors, the annonaceous acetogenins. to determine the neurotoxic potential of these substances, we administered annonacin, the major acetogenin of a. muricata, to rats intravenously with azlet osmotic minipumps (3.8 and 7.6 mg per kg per day for 28 days). annonacin in ... | 2004 | 14675150 |
| isolation and characterization of a lectin from annona muricata seeds. | a lectin with a high affinity for glucose/mannose was isolated from annona muricata seeds (annonaceae) by gel filtration chromatography on sephacryl s-200, ion exchange chromatography on a deae sp-5 pw column, and molecular exclusion on a protein pak glass 300 sw column. sodium dodecyl sulfate polyacrylamide gel electrophoresis (page) yielded two protein bands of approximately 14 kda and 22 kda. however, only one band was seen in native page. the mr of the lectin estimated by fast-performance li ... | 2003 | 14714732 |
| nutritional and sensory quality of stirred soursop (annona muricata l.) yoghurt. | soursops (annona muricata l.) are highly aromatic fruits with white juicy flesh and are native to tropical north and south america. the ripe fruits are highly perishable, as they become soft and easily bruised. the objectives of the study were to incorporate soursop nectar at 0%, 5%, 10% and 15% in stirred yoghurts and to analyse the products for chemical and sensory quality. a focus group evaluated the initial yoghurts for process modifications. yoghurts were evaluated on sensory attributes of ... | 2004 | 15545049 |
| quantification of acetogenins in annona muricata linked to atypical parkinsonism in guadeloupe. | atypical parkinsonism in guadeloupe has been associated with the consumption of fruit and infusions or decoctions prepared from leaves of annona muricata l. (annonaceae), which contains annonaceous acetogenins, lipophilic inhibitors of complex i of the mitochondrial respiratory chain. we have determined the concentrations of annonacin, the major acetogenin in a. muricata, in extracts of fruit and leaves by matrix-assisted laser desorption-ionization mass spectrometry. an average fruit is estimat ... | 2005 | 16078200 |
| is atypical parkinsonism in the caribbean caused by the consumption of annonacae? | an abnormally frequent atypical levodopa-unresponsive, akinetic-rigid syndrome with some similarity to psp was identified in the caribbean island guadeloupe, and was associated with the consumption of plants of the annonacea family, especially annona muricata (corossol, soursop) suggesting a possible toxic etiology. annonaceae contain two groups of potential toxins, alkaloids and acetogenins. both alkaloids and annonacin, the most abundant acetogenin, were toxic in vitro to dopaminergic and othe ... | 2006 | 17017523 |
| ethnomedicines used in trinidad and tobago for urinary problems and diabetes mellitus. | this paper is based on ethnobotanical interviews conducted from 1996-2000 in trinidad and tobago with thirty male and female respondents. | 2006 | 17040567 |
| antiprotozoal and cytotoxic activities in vitro of colombian annonaceae. | ethnobotanical and chemotaxonomical studies for antiparasitic activity of colombian annonaceae were carried out. in vitro antiprotozoal activity of 36 extracts obtained from six different species was determined against promastigotes of three leishmania species, epimastigotes of trypanosoma cruzi and both chloroquine sensitive (f32) and resistant (w2) plasmodium falciparum. cytotoxic activity was evaluated in u-937 cells. active extracts were selected according their selectivity index (si). extra ... | 2007 | 17296281 |
| atypical parkinsonism in guadeloupe: a common risk factor for two closely related phenotypes? | in guadeloupe, there is an abnormally high frequency of atypical parkinsonism. only one-third of the patients that develop parkinsonian symptoms were reported to present the classical features of idiopathic parkinson disease and one-third a syndrome resembling progressive supranuclear palsy (psp). the others were unclassifiable, according to established criteria. we carried out a cross-sectional study of 160 parkinsonian patients to: (i) define more precisely the clinical phenotypes of the psp-l ... | 2007 | 17303592 |
| atypical parkinsonism in the caribbean island of guadeloupe: etiological role of the mitochondrial complex i inhibitor annonacin. | on the french west indian island of guadeloupe, atypical parkinsonian patients represent two-thirds of all cases of parkinsonism, which is exceptionally frequent compared to epidemiological data from european countries where atypical parkinsonism accounts for only approximately 5% of all cases. the clinical entity was a unique combination of levodopa-resistant parkinsonism, tremor, myoclonus, hallucinations, rem sleep behavior disorder and fronto-subcortical dementia. based on the presence or th ... | 2008 | 18816693 |
| identification of annonaceous acetogenins in the ripe fruit of the north american pawpaw ( asimina triloba ). | the north american pawpaw [ asimina triloba (l.) dunal] is a tree fruit in the early stages of commercial production in the united states. this plant contains annonaceous acetogenins in the twigs, unripe fruit, seeds, roots, and bark tissues, which display antitumor, pesticidal, antimalarial, anthelmintic, piscicidal, antiviral, and antimicrobial effects, suggesting many potentially useful applications. however, commercial development of these compounds, based on twig extracts, has been problema ... | 2009 | 19711911 |
| analysis of the polyphenols content in medicinal plants based on the reduction of cu(ii)/bicinchoninic complexes. | a spectrophotometric method is proposed for the determination of the polyphenols content in aqueous extracts of plants. the method is based on the reduction of cu(ii) to cu(i) by polyphenols, in the presence of bicinchoninic acid in a buffered medium (ammonium acetate, ph 7.0) with the formation of cu(i)/bca complexes. a calibration curve of absorbance (at 558 nm) vs tannic acid concentration is linear (r = 0.995; n = 7) with tannic acid from 0.1 to 0.7 micromol l(-1). the limit of detection and ... | 2009 | 19899763 |
| maldi-tof ms profiling of annonaceous acetogenins in annona muricata products for human consumption. | annonaceous acetogenins are proposed as environmental neurotoxicants consumed through medicinal and alimentary habits and responsible for atypical parkinsonian syndromes observed in tropical areas. potential sources of exposure still have to be determined, as, to date, only a few batches of products for human consumption were searched for these compounds. to assess the presence of acetogenins, we propose a fast, sensitive and accurate method of screening, using maldi-tof ms, with minimal sample ... | 2009 | 20032889 |
| [plant extracts in control of rhipicephalus (boophilus) microplus (canestrini, 1887) (acari: ixodidae) in laboratory]. | plant extracts were studied to evaluate its efficiency in the control of rhipicephalus (boophilus) microplus (canestrini, 1887) in laboratory. engorged female ticks were collected from the cattle, kept in petri dishes. organic alcoholic extracts 2% (weight/volume) were used: seeds of annona muricata l. (annonaceae) (soursop); flowers of syzygium malaccensis (l.) (myrtaceae) (iamb), leaves of cymbopogon citratus (dc.) stapf (poaceae) (holy grass), leaves of azadirachta indica a. juss (meliaceae) ... | 2009 | 20040208 |
| protective effects of annona muricata linn. (annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozotocin-treated diabetic rats. | extracts from various morphological parts of annona muricata linn. (annonaceae) are widely used medicinally in many parts of the world for the management, control and/or treatment of a plethora of human ailments, including diabetes mellitus (dm). the present study was undertaken to investigate the possible protective effects of a. muricata leaf aqueous extract (ame) in rat experimental paradigms of dm. the animals used were broadly divided into four (a, b, c and d) experimental groups. group a r ... | 2008 | 20162039 |
| anti hyperglycemic activities of annona muricata (linn). | this study was designed to determine the effects of methanolic extracts of annona muricata (linn) on the blood glucose level of streptozotocin-induced diabetic wistar rats. thirty adult wistar rats were randomly assigned into three groups (a, b and c) of ten rats each. group a was the control, group b was untreated hyperglycemic group and group c was a. muricata-treated group. hyperglycemia was induced in groups b and c by a single intraperitoneal injection of 80 mg/kg streptozotocin dissolved i ... | 2008 | 20162043 |
| complex i: inhibitors, inhibition and neurodegeneration. | complex i is the first protein component of the mitochondrial respiratory chain and as such plays a crucial role in atp production and mitochondrial function in general. mitochondrial dysfunction has been identified in a number of neurodegenerative diseases. in some of these the mitochondrial abnormality is primary and in others secondary. mitochondrial toxins are capable of producing relatively selective neuronal cell death and have been used to produce models of human neurodegenerative disease ... | 2010 | 20362572 |
| histomorphological and morphometric studies of the pancreatic islet cells of diabetic rats treated with extracts of annona muricata. | microanatomical changes in the pancreatic islet cells of streptozotocin induced diabetic wistar rats were studied after treatment with methanolic extracts of annona muricata leaves. thirty adult wistar rats were randomly assigned into three groups (control, untreated diabetic group, and a. muricata-treated diabetic group) of ten rats each. diabetes mellitus was experimentally induced in groups b and c by a single intra-peritoneal injection of 80 mg/kg streptozotocin dissolved in 0.1 m citrate bu ... | 2010 | 20512759 |
| antibacterial effect (in vitro) of moringa oleifera and annona muricata against gram positive and gram negative bacteria. | antibacterial effects of aqueous and ethanolic extracts of seeds of moringa (moringa oleifera) and pods of soursop (annona muricata) in the concentration of 1:5 and 1:10 in volumes 50, 100, 150 and 200 microl were examined against staphylococcus aureus, vibrio cholerae, escherichia coli (isolated from the organism and the aquatic environment) and salmonella enteritidis. antibacterial activity (inhibition halo > 13 mm) against s. aureus, v. cholerae and e. coli isolated from the whiteleg shrimp, ... | 2010 | 20602021 |
| annonacin induces cell cycle-dependent growth arrest and apoptosis in estrogen receptor-+¦-related pathways in mcf-7 cells. | ethnopharmacological relevance: tamoxifen resistance is common in estrogen receptor-+¦ (er+¦)-positive breast cancers. pawpaw and soursop are anticancer annonaceous plants in complementary medicine. thus, we studied the effects of annonacin, an annonaceous acetogenin, in breast cancer cells. materials and methods: cell growth and er+¦-related pathways were studied. the effects of annonacin were tested in mcf-7 xenografts in nude mice. results: in er+¦-positive mcf-7 cells, annonacin (half-effect ... | 2011 | 21840388 |
| leishmanicidal activity and cytotoxicity of compounds from two annonacea species cultivated in northeastern brazil. | visceral leishmaniasis is endemic in 88 countries, with a total of 12 million people infected and 350 million at risk. in the search for new leishmanicidal agents, alkaloids and acetogenins isolated from leaves of annona squamosa and seeds of annona muricata were tested against promastigote and amastigote forms of leishmania chagasi. | 2011 | 22031071 |
| estimation of phytochemicals and antioxidant activity of underutilized fruits of andaman islands (india). | the present study aimed to determine the antioxidant activity and phytochemical contents in 10 underutilized fruits of andaman islands (india) namely malpighia glabra l., mangifera andamanica l., morinda citrifolia l., syzygium aqueum (burm.f) alst., annona squamosa l., averrhoa carambola l., averrhoa bilimbi l., dillenia indica l., annona muricata l. and ficus racemosa l. the antioxidant activity varied from 74.27% to 98.77%, and the methanol extract of m. glabra showed the highest antioxidant ... | 2011 | 22080844 |
| annonacin in asimina triloba fruit: implication for neurotoxicity. | introduction: the acetogenin, annonacin, from the tropical annonaceous plant annona muricata, is a lipophilic, mitochondrial complex i inhibitor reported to be more toxic than rotenone to mesencephalic neurons. the temperate annonaceous plant asimina triloba (pawpaw) is native to the eastern united states and products are available online. this study determined whether annonacin is in the pawpaw fruit pulp and whether it or the crude ethyl acetate extract is toxic to cortical neurons. methods: p ... | 2011 | 22130466 |
| two new terpenoids from endophytic fungus periconia sp. f-31. | two new terpenoids, (+)-(3s,6s,7r,8s)-periconone a (1) and (-)-(1r,4r,6s,7s)-2-caren-4,8-olide (2), have been isolated from an endophytic fungus periconia sp., which was collected from the plant annona muricata. their structures were elucidated on the basis of extensive spectroscopic analyses. in the in vitro assays, the two compounds showed low cytotoxic activities against six human tumor cell lines (hct-8, bel-7402, bgc-823, a549, a2780 and mcf-7) with ic(50)>10(-5) m. | 2011 | 22130377 |
| cytotoxicity of methanol extracts of annona muricata, passiflora edulis and nine other cameroonian medicinal plants towards multi-factorial drug-resistant cancer cell lines. | cancer cells rapidly acquire resistance leading to treatment failures. in the present study, we have evaluated the cytotoxicity of 17 methanol extracts from 11 cameroonian medicinal plants against the sensitive leukemia ccrf-cem cells and the best ones were further tested on a panel of 8 other human cancer cell lines, including various mdr phenotypes as well as against the normal aml12 hepatocytes. | 2016 | 27730025 |
| annona muricata (annonaceae): a review of its traditional uses, isolated acetogenins and biological activities. | annona muricata is a member of the annonaceae family and is a fruit tree with a long history of traditional use. a. muricata, also known as soursop, graviola and guanabana, is an evergreen plant that is mostly distributed in tropical and subtropical regions of the world. the fruits of a. muricata are extensively used to prepare syrups, candies, beverages, ice creams and shakes. a wide array of ethnomedicinal activities is contributed to different parts of a. muricata, and indigenous communities ... | 2015 | 26184167 |
| stability, antimicrobial activity, and effect of nisin on the physico-chemical properties of fruit juices. | heat processing is the most commonly used hurdle for inactivating microorganisms in fruit juices. however, this preservation method could interfere with the organoleptic characteristics of the product. alternative methods have been proposed and bacteriocins such as nisin are potential candidates. however, the approval of bacteriocins as food additives is limited, especially in foods from vegetal origin. we aimed to verify the stability, the effect on physico-chemical properties, and the antimicr ... | 2015 | 26162590 |
| anti-microbial efficacy of soursop leaf extract (annona muricata) on oral pathogens: an in-vitro study. | annona muricata also called as soursop is a, flowering evergreen tree native to mexico, cuba, central america and parts of india. the miracle tree as it is widely known as a natural cancer killer that is 10,000 times stronger than chemotherapy. based on these miraculous claims, the leaves of these plants were used as an extract at varying concentrations as an antibacterial agent against oral pathogens. | 2016 | 28050493 |
| antibacterial activity of leaf extract of annona muricata and simarouba glauca on enterococcus faecalis. | to determine the antimicrobial effect of water extracts of leaves of annona muricata and simarouba glauca on enterococcus faecalis using agar diffusion method. | 2016 | 27659082 |
| identification of lactic acid bacteria in fruit pulp processing byproducts and potential probiotic properties of selected lactobacillus strains. | this study aimed to identify lactic acid bacteria (lab) in byproducts of fruit (malpighia glabra l., mangifera indica l., annona muricata l., and fragaria vesca l.) pulp processing. fifty strains of lab were identified using matrix-assisted laser desorption/ionization-time of flight mass spectrometry (maldi-tof ms) and 16s rrna gene sequence (16s rrna) analysis. species belonging to lactobacillus genus were the predominant lab in all fruit pulp processing byproducts. the average congruency betwe ... | 2016 | 27625647 |
| antibacterial activities of the methanol extracts of canarium schweinfurthii and four other cameroonian dietary plants against multi-drug resistant gram-negative bacteria. | bacterial infections are among the major cause of morbidity and mortality worldwide. the present study was designed to evaluate the in vitro antibacterial activities of the methanol extracts of five cameroonian edible plants namely colocasia esculenta, triumfetta pentandra, hibiscus esculentus, canarium schweinfurthii and annona muricata against a panel of 19 multidrug resistant gram-negative bacterial strains. the liquid broth microdilution was used to determine the minimal inhibitory concentra ... | 2016 | 27579004 |
| in vitro anthelmintic activity of aqueous leaf extract of annona muricata l. (annonaceae) against haemonchus contortus from sheep. | despite the overall progress of sheep farming in brazil, infections with the gastrointestinal parasite haemonchus contortus represent one the most important problems in sheep production, aggravated by the increasing resistance of nematodes to traditional anthelmintic drugs caused by inadequate sheep flock management by breeders. ethnopharmacological data indicate annona muricata as a promising alternative for the control of gastrointestinal nematodes because of its general anthelmintic propertie ... | 2013 | 23583362 |
| different susceptibilities of leishmania spp. promastigotes to the annona muricata acetogenins annonacinone and corossolone, and the platymiscium floribundum coumarin scoparone. | leishmaniasis is a zoonotic disease that can manifest itself in visceral and cutaneous form. the aim of this study was to search for new leishmanicidal compounds. preliminarily, artemia salina assay was applied to compounds from two plants found in northeastern brazil, platymiscium floribundum and annona muricata. then these compounds were tested against three leishmania species (leishmania donovani, leishmania mexicana and leishmania major). a screening assay using luciferase-expressing promast ... | 2013 | 23232251 |
| [analysis of the microbiological quality and potential presence of listeria monocytogenes in custard apple (annona muricata), mango (mangifera indica) and passion fruit (passiflora edulis) pulps from costa rica]. | the objective of this work was to determine some of the indicators associated to shelf life, hygiene, process and storage conditions for some of custard apple, mango and passion fruit pulps distributed by the main supermarket chains of the metropolitan area of san josé, costa rica, as well as to examine the potential presence of listeria monocytogenes in them. sixty fruit pulp samples were analyzed. tests included ph determination, total aerobic plate count, yeasts and mold count, lactic bacteri ... | 2013 | 24167958 |
| [plant extracts with cytostatic properties growing in cuba. i]. | the cytostatic activity of aqueous, alcoholic and ketonic extracts of 9 species of superior plants of the families fitolacaceae, compositae, moraceae, zingiberaceae, martiniaceae, mirtaceae, verbenaceae and annonaceae was assessed. the kubas microbiologic method and the fungus ascomiceto neurospora crassa were used in the assessment. the fungus growth was measured in millimeters. inhibition percentages for every case regarding control are reported. the best results were obtained from annona muri ... | 2009 | 161407 |
| isolation and identification of biocellulose-producing bacterial strains from malaysian acidic fruits. | biocellulose (bc) is pure extracellular cellulose produced by several species of micro-organisms that has numerous applications in the food, biomedical and paper industries. however, the existing biocellulose-producing bacterial strain with high yield was limited. the aim of this study was to isolate and identify the potential biocellulose-producing bacterial isolates from malaysian acidic fruits. one hundred and ninety-three bacterial isolates were obtained from 19 local acidic fruits collected ... | 2016 | 27002476 |
| in vivo antimalarial activity of annona muricata leaf extract in mice infected with plasmodium berghei. | malaria is one of the most important infectious diseases in the world. the choice for the treatment is highly limited due to drug resistance. hence, finding the new compounds to treat malaria is urgently needed. the present study was attempted to evaluate the antimalarial activity of the annona muricata aqueous leaf extract in plasmodium berghei infected mice. aqueous leaf extract of a. muricata was prepared and tested for acute toxicity in mice. for efficacy test in vivo, standard 4-day suppres ... | 2016 | 27092277 |
| effect of selected local medicinal plants on the asexual blood stage of chloroquine resistant plasmodium falciparum. | the development of resistant to current antimalarial drugs is a major challenge in achieving malaria elimination status in many countries. therefore there is a need for new antimalarial drugs. medicinal plants have always been the major source for the search of new antimalarial drugs. the aim of this study was to screen selected malaysian medicinal plants for their antiplasmodial properties. | 2014 | 25510573 |
| [survival of trypanosoma cruzi in experimentally contaminated drinks]. | trypanosoma cruzi is the causative agent of chagas disease, transmitted primarily by triatomine insects. however, in 2005, oral transmission was documented in countries where the disease is endemic for chagas disease. this trend may also occur in colombia, a situation that motivated epidemiological alerts and the necessity for exploring the risk level of oral, human-to-human infection by t. cruzi. | 2014 | 23235795 |
| beneficial effect of medicinal plants on the contractility of post-hypoxic isolated guinea pig atria - potential implications for the treatment of ischemic-reperfusion injury. | context ischemic-reperfusion injury is accompanied by a decreased contractility of the myocardium. positive-inotropic agents have proven useful for treating this condition but may exert serious side-effects. objective in this study, aqueous preparations from abelmoschus esculentus l. moench (malvaceae), annona muricata l. (annonaceae), bixa orellana l. (bixaceae), cecropia peltata l. (moraceae), erythrina fusca lour. (fabaceae), psidium guajava l. (myrtaceae) and terminalia catappa l. (combretac ... | 2016 | 26730936 |
| spectral and hrtem analyses of annona muricata leaf extract mediated silver nanoparticles and its larvicidal efficacy against three mosquito vectors anopheles stephensi, culex quinquefasciatus, and aedes aegypti. | mosquitoes transmit various diseases which mainly affect the human beings and every year cause millions of deaths globally. currently available chemical and synthetic mosquitocidal agents pose severe side effects, pollute the environment vigorously, and become resistance. there is an urgent need to identify and develop the cost effective, compatible and eco-friendly product for mosquito control. the present study was aimed to find out the larvicidal potential of aqueous crude extract and green s ... | 2015 | 26410042 |
| annona muricata leaf extract-mediated silver nanoparticles synthesis and its larvicidal potential against dengue, malaria and filariasis vector. | mosquitoes transmit several diseases which cause millions of deaths every year. the use of synthetic insecticides to control mosquitoes caused diverse effects to the environment, mammals, and high manufacturing cost. the present study was aimed to test the larvicidal activity of green synthesized silver nanoparticles using annona muricata plant leaf extract against third instar larvae of three medically important mosquitoes, i.e., aedes aegypti, anopheles stephensi, and culex quinquefasciatus. t ... | 2015 | 26002825 |
| synergistic larvicidal effect and morphological alterations induced by ethanolic extracts of annona muricata and piper nigrum against the dengue fever vector aedes aegypti. | phytopesticide combinations of different botanical sources are seldom reported. annona muricata seed and piper nigrum fruit ethanolic extracts enriched in acetogenins and piperamides, respectively, were synergistically used as larvicides against the dengue fever vector aedes aegypti. | 2013 | 23112098 |
| ethnobotanical study of medicinal plants used in the management of diabetes mellitus and hypertension in the central region of togo. | the tem tribe in the central region of togo is a population with an extensive knowledge of medicinal plants. however, little is known about their medical practices, principally the use of plants in the management of diabetes mellitus (dm) and hypertension (htn). | 2011 | 22077164 |
| herbal remedies and functional foods used by cancer patients attending specialty oncology clinics in trinidad. | cancer is a major disease worldwide, and many patients use complementary and alternative treatments. the purpose of this study was to identify the herbal remedies and functional foods used as complementary medicine by prostate, breast and colorectal cancer patients at speciality care facilities in trinidad. we also sought to determine how patients rated the efficacy of these modalities compared with conventional treatment. | 2016 | 27769229 |
| an appraisal of eighteen commonly consumed edible plants as functional food based on their antioxidant and starch hydrolase inhibitory activities. | eighteen edible plants were assessed for their antioxidant potential based on oxygen radical absorbance capacity (orac), 2,2-diphenyl-1-picrylhydrazyl (dpph) radical scavenging activity, total phenolics, vitamin c content and various lipophilic antioxidants. the inhibitory activities of the plant extracts against the enzymatic activities of α-amylase and α-glucosidase were also evaluated. | 2015 | 25491037 |
| the association between chromaticity, phenolics, carotenoids, and in vitro antioxidant activity of frozen fruit pulp in brazil: an application of chemometrics. | a total of 19 brazilian frozen pulps from the following fruits: açai (euterpe oleracea), blackberry (rubus sp.), cajá (spondias mombin), cashew (anacardium occidentale), cocoa (theobroma cacao), coconut (cocos nucifera), grape (vitis sp.), graviola (annona muricata), guava (psidium guajava), papaya (carica papaya), peach (prunus persica), pineapple (ananas comosus), pineapple and mint (a. comosus and mentha spicata), red fruits (rubus sp. and fragaria sp.), seriguela (spondias purpurea), strawbe ... | 2014 | 24547813 |
| quantification of bioactive compounds in pulps and by-products of tropical fruits from brazil. | this study aimed to quantify the levels of resveratrol, coumarin, and other bioactives in pulps and by-products of twelve tropical fruits from brazil obtained during pulp production process. pineapple, acerola, monbin, cashew apple, guava, soursop, papaya, mango, passion fruit, surinam cherry, sapodilla, and tamarind pulps were evaluated as well as their by-products (peel, pulp's leftovers, and seed). total phenolic, anthocyanins, yellow flavonoids, β-carotene and lycopene levels were also deter ... | 2014 | 24054258 |
| exploratory studies on the in vitro anti-inflammatory potential of two herbal teas (annona muricata l. and jasminum grandiflorum l.), and relation with their phenolic composition. | the need of new anti-inflammatory drugs has led to the search for safer and more potent molecules in distinct sources, such as natural products. this work aimed to explore the anti-inflammatory potential of aqueous extracts from two herbal teas (annona muricata l. and jasminum grandiflorum l.) in raw 264.7 macrophages cells and in cell-free assays. furthermore, the phenolic composition of both extracts and of their hydrolysates was characterized by hplc-dad, in order to establish possible relati ... | 2017 | 28256049 |
| antinociceptive and antihyperalgesic activity of a traditional maya herbal preparation composed of pouteria campechiana, chrysophyllum cainito, citrus limonum, and annona muricata. | preclinical research the purpose of this work was to assess the antinociceptive and antihyperalgesic properties of an herbal preparation, composed of four vegetal species: pouteria campechiana (p. campechiana), chrysophyllum cainito (c. cainito), citrus limonum (c. limonum), and annona muricata (a. muricata), that is commonly used in combination (pcca) in traditional mayan medicine for the treatment of diabetes and pain. an ethanolic extract of pcca was prepared at a ratio of 1:1:1:1 for each pl ... | 2017 | 28176363 |
| immunomodulatory efficacy of standardized annona muricata (graviola) leaf extract via activation of mitogen-activated protein kinase pathways in raw 264.7 macrophages. | annona muricata, commonly known as graviola, has been utilized as a traditional medicine to treat various human diseases. the aim of this study was to examine the immune-enhancing activity of graviola leaf extracts in raw 264.7 macrophage cells. active ingredients in graviola leaf extracts (ge) were identified as kaempferol-3-o-rutinoside and quercetin-3-o-rutinoside by lc-ms/ms. when treated with steam or 50% ethanol ge, cell morphology was altered due to initiation of cell differentiation. whi ... | 2016 | 28096884 |
| (1) h qnmr quantification of annonaceous acetogenins in crude extracts of annona muricata l. fruit pulp. | annonaceous acetogenins (aags) constitute a group of environmental neurotoxins, possibly implicated in sporadic atypical parkinsonism/dementia complexes. the recent evidencing of complex mixtures of aags in edible fruits and derived food products requires efficient and practical analytical tools for an estimation of human exposure. | 2017 | 28092423 |
| influence of different extraction conditions on antioxidant properties of soursop peel. | soursop is a healthy fruit. peels form about 20% of the soursop fruit and are usually discarded as waste product. with a view to utilizing soursop peel as a source of valuable compounds, this study aimed to investigate the influence of different extraction conditions on total phenolic content (tpc) and antioxidant capacity (ac) of soursop (annona muricata l.) peel. | 2017 | 28071019 |
| antiallergic effect of the atomized extract of rhizome of curcuma longa, flowers of cordia lutea and leaves of annona muricata. | allergies are a problem that greatly affects the population, and hence the use of antiallergic medications is fairly widespread. however, these drugs have many adverse effects. the use of medicinal plants could be an option, but they need to be evaluated. | 2016 | 27877047 |
| valorization of soursop flowers (annona muricata l.) as potent source of natural antioxidants for stabilization of palm olein during accelerated storage. | this study investigates the effect of soursop flowers methanolic extract on the physicochemical characteristics of palm olein during accelerated storage. after analysis of the extract by determining its total phenolic content by colorimetry and identification of some of its phenolic antioxidants by hplc-dad(diode array detector), preliminary antioxidants tests have been done. after that, the extract was added in palm olein at concentrations 200-1800 ppm. bht, at 200 ppm served as standard beside ... | 2016 | 27826429 |
| application of the quechers method for the determination of organochlorine pesticide residues in brazilian fruit pulps by gc-ecd. | the quick, easy, cheap, effective, rugged, and safe (quechers) method was applied to the extraction of 14 organochlorine pesticides (ocps) residues from commercial fruit pulps available in supermarkets in fortaleza, northeastern brazil. the analyses were carried out by gas chromatography (gc), coupled to an electron-capture detector (ecd), and were confirmed by gc-tandem mass spectrometry (ms). the parameters of the analytical method, such as accuracy, precision, linear range, limits of detectio ... | 2017 | 27726598 |
| chronic consumption of annona muricata juice triggers and aggravates cerebral tau phosphorylation in wild-type and mapt transgenic mice. | in the pathogenesis of tauopathies, genetic and environmental factors have been identified. while familial clustering led to the identification of mutations in mapt encoding the microtubule-associated protein tau, the high incidence of a sporadic tauopathy endemic in guadeloupe was linked to the plant-derived mitochondrial complex i inhibitor annonacin. the interaction of both factors was studied in the present work in a realistic paradigm over a period of 12 months. mice over-expressing either ... | 2016 | 27569447 |
| anti-cancer effect of annona muricata linn leaves crude extract (amce) on breast cancer cell line. | annona muricata linn which comes from annonaceae family possesses many therapeutic benefits as reported in previous studies and to no surprise, it has been used in many cultures to treat various ailments including headaches, insomnia, and rheumatism to even treating cancer. however, annona muricata linn obtained from different cultivation area does not necessarily offer the same therapeutic effects towards breast cancer (in regards to its bioactive compound production). in this study, anti-proli ... | 2016 | 27558166 |
| polyketide natural products, acetogenins from graviola (annona muricata l), its biochemical, cytotoxic activity and various analyses through computational and bio-programming methods. | plants became the basis of traditional medicine system throughout the world for thousands of years and continue to provide mankind with new remedies. annona muricata, the plant of annonaceae family, is also known as sour sop or graviola. in recent years, many compounds have been reported and have gained organic chemist's and biochemist's attention because of their novel structure and wide range of bioactivity. local populations have used the bark, leaves, roots, fruit, seeds and flowers for thou ... | 2016 | 27262333 |
| functional proteomic analysis revels that the ethanol extract of annona muricata l. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway. | annona muricata l. is used to treat cancer in some countries. extracts of annona muricata have been shown to cause apoptosis of various cancer cells in vitro, and inhibit tumor growth in vivo in animal models. however, the molecular mechanisms underlying its anti-cancer and apoptotic effects of the herb remain to be explored. | 2016 | 27224241 |
| acetogenins from annona muricata as potential inhibitors of antiapoptotic proteins: a molecular modeling study. | apoptosis is a highly regulated process crucial for maintaining cellular homeostasis and development. the b-cell lymphoma 2 (bcl-2) family of proteins play a crucial role in regulating apoptosis. overexpressed bcl-2 proteins are associated with the development and progression of several human cancers. annona muricata is a tropical plant that belongs to the annonaceae family and is well known for its anticancer properties. in this study, molecular docking and simulations were performed to investi ... | 2016 | 27110097 |
| toxicology of a peruvian botanical remedy to support healthy liver function. | the purpose of these studies was to determine the safety of a botanical treatment for supporting healthy liver function developed in peru. the formulation, a4+, contains extracts of curcuma longa l. rhizome (a4r), cordia lutea lam. flower (a4f) and annona muricata l. leaf (a4l). the tests were used to support an application for a non-traditional natural health product licence from the natural health product directorate of health canada and future clinical trials. | 2016 | 27101557 |
| experimental lachesis muta rhombeata envenomation and effects of soursop (annona muricata) as natural antivenom. | in the atlantic forest of the north and northeast regions of brazil, local population often uses the fruit juice and the aqueous extract of leaves of soursop (annona muricata l.) to treat lachesis muta rhombeata envenomation. envenomation is a relevant health issue in these areas, especially due to its severity and because the production and distribution of antivenom is limited in these regions. the aim of the present study was to evaluate the relevance of the use of soursop leaf extract and its ... | 2016 | 26957955 |
| distribution of phenolic contents, antidiabetic potentials, antihypertensive properties, and antioxidative effects of soursop (annona muricata l.) fruit parts in vitro. | soursop fruit has been used in folklore for the management of type-2 diabetes and hypertension with limited information on the scientific backing. this study investigated the effects of aqueous extracts (1 : 100 w/v) of soursop fruit part (pericarp, pulp, and seed) on key enzymes linked to type-2 diabetes (α-amylase and α-glucosidase) and hypertension [angiotensin-i converting enzyme (ace)]. radicals scavenging and fe(2+) chelation abilities and reducing property as well as phenolic contents of ... | 2015 | 26788368 |
| vortex- and co2 -gas-assisted liquid-liquid microextraction with salt addition for the high-performance liquid chromatographic determination of furanic compounds in concentrated juices and dried fruits. | a novel microextraction method based on vortex- and co2 -assisted liquid-liquid microextraction with salt addition for the isolation of furanic compounds (5-hydroxymethyl-2-furaldehyde, 5-methyl-2-furaldehyde, 2-furaldehyde, 3-furaldehyde, 2-furoic and 3-furoic acids) was developed. purging the sample with co2 was applied after vortexing to enhance the phase separation and mass transfer of the analytes. the optimum extraction conditions were: extraction solvent (volume), propyl acetate (125 μl); ... | 2016 | 26718308 |
| evaluation of cytotoxicity of aqueous extract of graviola leaves on squamous cell carcinoma cell-25 cell lines by 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide assay and determination of percentage of cell inhibition at g2m phase of cell cycle by flow cytometry: an in vitro study. | malignancies constitute a wide variety of disorders having high mortality and morbidity rates. current protocols for management include surgical intervention, chemotherapy, and radiation which possess numerous adverse effects. many phytochemicals are available with anticancer properties similar to anticancer drugs. major benefit of these compounds is apparent lack of toxicity to normal tissues. graviola (botanical name: annona muricata) contain bioactive compound "annonaceous acetogenins" known ... | 2017 | 26681860 |
| thermal processing alters the chemical quality and sensory characteristics of sweetsop (annona squamosa l.) and soursop (annona muricata l.) pulp and nectar. | the objective of this study was to investigate the effect of thermal processing on the chemical quality and sensory characteristics of annona squamosa l. and annona muricata l. fruit pulps and nectar. the fruit pulps were pasteurized at 85 °c for 20 min and nectar prepared as per food safety and standards authority of india (fssai) specifications. the chemical composition of fresh and heated pulps of a. squamosa and a. muricata showed that compared to fresh, the chemical profile and sensory prof ... | 2016 | 26642109 |
| a systematic review of medicinal plants used for weight loss in brazil: is there potential for obesity treatment? | obesity is a pandemic disease and its prevalence is still increasing. moreover, it has important costs to public health. in brazil, many plants are used for weight loss by overweight or obese people, but there is a lack of scientific basis for this practice. many ethnobotanical studies aiming to characterize this usage have been published, but they are still limited by the region considered and the diversity of the popular knowledge. | 2015 | 26520790 |
| method development for quantification of the environmental neurotoxin annonacin in rat plasma by uplc-ms/ms and application to a pharmacokinetic study. | annonacin is an environmental neurotoxin identified in the pulp of several fruits of the annonaceae family (for example in annona muricata, asimina triloba), whose consumption was linked with the occurrence of sporadic atypical parkinsonism with dementia. pharmacokinetic parameters of this molecule are unknown. a method for its quantification in rat plasma was developed, using its analogue annonacinone as an internal standard. extraction from plasma was performed using ethylacetate with a good r ... | 2015 | 26444335 |
| neurotoxicity of dietary supplements from annonaceae species. | dietary supplements containing plant materials of annonaceae species (annona muricata l., a. squamosa l., a. mucosa jacq., a. squamosa × cherimola mabb.) were extracted by hot, pressurized ethyl acetate and analyzed for their effect in vitro on lund human mesencephalic neurons. cell viability was measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and cell death was determined by lactate dehydrogenase levels. three supplements strongly decreased the cell viability ... | 2016 | 26405269 |
| isolation of three new annonaceous acetogenins from graviola fruit (annona muricata) and their anti-proliferation on human prostate cancer cell pc-3. | bioassay-guided fractionation of the fruit powder of graviola (annona muricata) was continued to be conducted and yielded three more novel bioactive compounds: c-35 annonaceous acetogenins, muricins m and n, and c-37 annonaceous acetogenins, muricenin. they all contain a mono-tetrahydrofuran ring and four hydroxyl groups. the structures were elucidated by spectral methods and chemical modification after isolation via open column chromatographic separation and hplc purification. especially, muric ... | 2016 | 27499453 |
| in vitro protective potentials of annona muricata leaf extracts against sodium arsenite-induced toxicity. | sodium arsenite (naaso2) is a metalloid which is present widely in the environment and its chronic exposure can contribute to the induction of oxidative stress, resulting in disturbances in various metabolic functions including liver cell death. hence, there is a need to develop drugs from natural sources, which can reduce arsenic toxicity. while there have been reports regarding the antioxidant and protective potentials of annona muricataleaf extracts, our study is the first ofits kind to exten ... | 2015 | 26033234 |
| annona muricata leaves accelerate wound healing in rats via involvement of hsp70 and antioxidant defence. | annona muricata, a member of the annonaceae family, is commonly known as soursop and graviola. the leaves of this tropical fruit tree are widely used in folk medicine against skin diseases and abscesses, however there is no scientific evidence justifying the use of a. muricata leaves. the aim of the present study is to evaluate the wound healing potential of ethyl acetate extract of a. muricata leaves (eeam) towards excisional wound models in rats. | 2015 | 25899210 |
| synergistic interactions among flavonoids and acetogenins in graviola (annona muricata) leaves confer protection against prostate cancer. | phytochemical complexity of plant extracts may offer health-promoting benefits including chemotherapeutic and chemopreventive effects. isolation of 'most-active fraction' or single constituents from whole extracts may not only compromise the therapeutic efficacy but also render toxicity, thus emphasizing the importance of preserving the natural composition of whole extracts. the leaves of annona muricata, commonly known as graviola, are known to be rich in flavonoids, isoquinoline alkaloids and ... | 2015 | 25863125 |
| the chemopotential effect of annona muricata leaves against azoxymethane-induced colonic aberrant crypt foci in rats and the apoptotic effect of acetogenin annomuricin e in ht-29 cells: a bioassay-guided approach. | annona muricata has been used in folk medicine for the treatment of cancer and tumors. this study evaluated the chemopreventive properties of an ethyl acetate extract of a. muricata leaves (eeaml) on azoxymethane-induced colonic aberrant crypt foci (acf) in rats. moreover, the cytotoxic compound of eeaml (annomuricin e) was isolated, and its apoptosis-inducing effect was investigated against ht-29 colon cancer cell line using a bioassay-guided approach. this experiment was performed on five grou ... | 2015 | 25860620 |
| antioxidant, dna protective efficacy and hplc analysis of annona muricata (soursop) extracts. | annona muricata is a naturally occurring edible plant with wide array of therapeutic potentials. in india, it has a long history of traditional use in treating various ailments. the present investigation was carried out to characterize the phytochemicals present in the methanolic and aqueous leaf extracts of a. muricata, followed by validation of its radical scavenging and dna protection activities. the extracts were also analyzed for its total phenolic contents and subjected to hplc analysis to ... | 2015 | 25829616 |
| antiproliferative activity and induction of apoptosis by annona muricata (annonaceae) extract on human cancer cells. | annona muricata (a. muricata) is widely distributed in asia, africa and south america. different parts of this plant are used to treat several diseases in cameroon. the aim of this study is to determine the in vitro anti-proliferative effects and apoptotic events of a. muricata extracts on hl-60 cells as well as to quantify its phenols content. | 2014 | 25539720 |