| sequences responsible for efficient replication of simian immunodeficiency virus sivmnd in cells of the monocyte/macrophage lineage. | we determined the susceptibility of monocytic cell lines to infection with viral strains derived from two infectious clones of simian immunodeficiency virus isolated from a mandrill. one of the strains, which replicates poorly in t cell lines, was found to grow more rapidly than the other in these cells. the viral determinant for this property was genetically mapped within the env gene encoding a surface protein. six amino acid substitutions identified appeared to be located outside of the domai ... | 1992 | 1431813 |
| the simian immunodeficiency virus mnd(gb-1) strain uses cxcr4, not ccr5, as coreceptor for entry in human cells. | the simian immunodeficiency virus (siv) mnd(gb-1) strain, isolated from a mandrill, replicates in a human t cell line, cem cells, and is inhibited by the cxc-chemokines, stromal cell-derived factor 1alpha and 1beta (sdf-1alpha/sdf-1beta), the natural ligands for cxcr4. the ic50 was around 70-80 ng/ml, which corresponds to the ic50 of sdf-1alpha/sdf-1beta for t-tropic human immunodeficiency virus type 1 (hiv-1) and hiv-2. the specific anti-cxcr4 mab 12g5 inhibited replication of sivmnd at an ic50 ... | 1998 | 9747729 |
| analysis of the effect of natural sequence variation in tat and in cyclin t on the formation and rna binding properties of tat-cyclin t complexes. | the biological activity of the human immunodeficiency virus type 1 (hiv-1) tat (tat1) transcriptional activator requires the recruitment of a tat1-cyclint1 (cyct1) complex to the tar rna target encoded within the viral long terminal repeat (ltr). while other primate immunodeficiency viruses, such as hiv-2 and mandrill simian immunodeficiency virus (sivmnd), also encode tat proteins that activate transcription via rna targets, these proteins differ significantly, both from each other and from tat ... | 1999 | 10364329 |
| high levels of viral replication contrast with only transient changes in cd4(+) and cd8(+) cell numbers during the early phase of experimental infection with simian immunodeficiency virus sivmnd-1 in mandrillus sphinx. | early events during human immunodeficiency virus infections are considered to reflect the capacity of the host to control infection. we have studied early virus and host parameters during the early phase of simian immunodeficiency virus sivmnd-1 nonpathogenic infection in its natural host, mandrillus sphinx. four mandrills were experimentally infected with a primary sivmnd-1 strain derived from a naturally infected mandrill. two noninfected control animals were monitored in parallel. blood and l ... | 2002 | 12239301 |
| primary simian immunodeficiency virus sivmnd-2 infection in mandrills (mandrillus sphinx). | mandrills are the only nonhuman primate (nhp) naturally infected by two types of simian immunodeficiency virus (siv): sivmnd-1 and sivmnd-2. we have already reported that the high sivmnd-1 replication during primary infection contrasts with only transient changes in cd4+ and cd8+ cell counts. since early virus-host interactions predict viral control and disease progression in human immunodeficiency virus-infected patients, we investigated the dynamics of sivmnd-2 primary infection in mandrills t ... | 2006 | 16537597 |
| immunovirological analyses of chronically simian immunodeficiency virus sivmnd-1- and sivmnd-2-infected mandrills (mandrillus sphinx). | simian immunodeficiency virus (siv) infection in african nonhuman primate (nhp) natural hosts is usually nonpathogenic, despite high levels of virus replication. we have previously shown that chronic siv infection in sooty mangabeys (sms) and african green monkeys (agms) is associated with low levels of immune activation and bystander t cell apoptosis. to compare these features with those observed in another natural host, the mandrill (mnd), we conducted a cross-sectional survey of the 23 siv-in ... | 2011 | 21957286 |
| immunological alterations and associated diseases in mandrills (mandrillus sphinx) naturally co-infected with siv and stlv. | mandrills are naturally infected with simian t-cell leukaemia virus type 1 (stlv-1) and simian immunodeficiency virus (siv)mnd. in humans, dual infection with human immunodeficiency virus (hiv) and human t-cell lymphotropic virus type 1 (htlv-1) may worsen their clinical outcome. we evaluated the effect of co-infection in mandrills on viral burden, changes in t-cell subsets and clinical outcome. the siv viral load was higher in siv-infected mandrills than in co-infected animals, whereas the stlv ... | 2014 | 24725945 |
| loss of memory cd4+ t-cells in semi-wild mandrills (mandrillus sphinx) naturally infected with species-specific simian immunodeficiency virus sivmnd-1. | simian immunodeficiency virus (siv) infection is found in a number of african primate species and is thought to be generally non-pathogenic. however, studies of wild primates are limited to two species, with siv infection appearing to have a considerably different outcome in each. further examination of siv-infected primates exposed to their natural environment is therefore warranted. we performed a large cross-sectional study of a cohort of semi-wild mandrills with naturally occurring siv infec ... | 2014 | 24214347 |
| reply to "control of simian immunodeficiency virus sivmnd-1 rna plasma viremia after coinfection or superinfection with sivmnd-1 in sivmnd-2-infected mandrills and vice versa". | | 2012 | 22282337 |
| control of simian immunodeficiency virus sivmnd-1 rna plasma viremia after coinfection or superinfection with sivmnd-1 in sivmnd-2-infected mandrills and vice versa. | | 2012 | 22282336 |