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sequence analysis and expression in escherichia coli of the hyaluronidase gene of streptococcus pyogenes bacteriophage h4489a.the hyaluronidase gene (hylp) from streptococcus pyogenes bacteriophage h4489a was previously cloned into escherichia coli plasmid puc8 as a 3.1-kilobase thai fragment. southern hybridization experiments confirmed the origin of this fragment in bacteriophage h4489a before determination of the nucleotide sequence of the entire fragment. two open reading frames (orfs) were found, the first of which specified a 39,515-molecular-weight protein identified as the bacteriophage hyaluronidase. the secon ...19892643574
the hyaluronan lyase of streptococcus pyogenes bacteriophage h4489a.many pathogenic streptococci produce extracellular hyaluronan lyases which are thought to aid the spread of the organism in host tissues. in addition, several phages of group a streptococci are known to synthesize a bound form of hyaluronidase. it has been suggested that the function of this hyaluronidase is to facilitate penetration of the hyaluronan capsule by phage and thus to gain access for the phage to the cell surface of the host streptococcus [hynes, hancock and ferretti (1995) infect. i ...200212071858
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